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Gene: Kifc1 (kinesin family member C1) Rattus norvegicus

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Symbol:

Kifc1

Name:

kinesin family member C1

RGD ID:

1359118

Description:

Predicted to enable ATP hydrolysis activity; microtubule binding activity; and minus-end-directed microtubule motor activity. Involved in spermatogenesis. Predicted to be located in endocytic vesicle and spindle pole centrosome. Predicted to be part of kinesin complex. Predicted to be active in cytoplasm; microtubule cytoskeleton; and nucleus. Orthologous to human KIFC1 (kinesin family member C1); INTERACTS WITH 1-naphthyl isothiocyanate; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

kinesin-like protein KIFC1; kinesin-related protein 1; kinesin-related protein KRP1; MGC94918

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	KIFC1 (kinesin family member C1)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OrthoDB, Panther, PhylomeDB, Treefam
Mus musculus (house mouse):	Kifc1 (kinesin family member C1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Kifc1 (kinesin family member C1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	KIFC1 (kinesin family member C1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	KIFC1 (kinesin family member C1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Kifc1 (kinesin family member C1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	KIFC1 (kinesin family member C1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	KIFC1 (kinesin family member C1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Kifc1 (kinesin family member C1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Homo sapiens (human):	KIFC1 (kinesin family member C1)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Kifc1 (kinesin family member C1)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Kifc5b (kinesin family member C5B)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	kifc1 (kinesin family member C1)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Saccharomyces cerevisiae (baker's yeast):	KAR3	Alliance	DIOPT (Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|SonicParanoid)
Caenorhabditis elegans (roundworm):	klp-16	Alliance	DIOPT (Ensembl Compara\|OMA\|PhylomeDB)
Drosophila melanogaster (fruit fly):	ncd	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	dcun1d5	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	kifc1	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PhylomeDB\|SonicParanoid)

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	20	5,000,929 - 5,018,967 (+)	NCBI		GRCr8
mRatBN7.2	20	4,998,832 - 5,017,107 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	20	4,999,047 - 5,017,105 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	20	5,722,546 - 5,742,381 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	20	5,084,291 - 5,104,118 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	20	5,564,478 - 5,582,550 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	20	5,509,059 - 5,526,175 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	20	5,509,059 - 5,526,175 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	20	7,567,671 - 7,585,188 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	20	5,150,810 - 5,169,264 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	20	5,151,036 - 5,169,489 (+)	NCBI
Celera	20	6,581,869 - 6,599,528 (+)	NCBI		Celera
Cytogenetic Map	20	p12	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

RGD Manual Disease Annotations Click to see Annotation Detail View

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Kifc1	Rat	COVID-19		ISO	RGD:1349353	9068941	mRNA:increased expression:peripheral blood mononuclear cell (human)	RGD	PMID:32228226\|REF_RGD_ID:28912744

Imported Disease Annotations - ClinVar

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Kifc1	Rat	autosomal dominant intellectual developmental disorder 5		ISO	RGD:1349353	8554872	ClinVar Annotator: match by term: Intellectual disability, autosomal dominant 5	ClinVar	PMID:28492532
Kifc1	Rat	MHC class I deficiency		ISO	RGD:1349353	8554872	ClinVar Annotator: match by term: MHC class I deficiency	ClinVar	PMID:28492532
Kifc1	Rat	proteasome-associated autoinflammatory syndrome 1		ISO	RGD:1349353	8554872	ClinVar Annotator: match by term: Proteasome-associated autoinflammatory syndrome 1	ClinVar	PMID:28492532

Imported Disease Annotations - CTD

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Kifc1	Rat	autism spectrum disorder		ISO	RGD:1349353	11554173	CTD Direct Evidence: marker/mechanism	CTD	PMID:35663546
Kifc1	Rat	hepatocellular carcinoma		ISO	RGD:1349353	11554173	CTD Direct Evidence: marker/mechanism	CTD	PMID:28284560
Kifc1	Rat	Triple Negative Breast Neoplasms		ISO	RGD:1349353	11554173	CTD Direct Evidence: marker/mechanism	CTD	PMID:26177331

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Kifc1	Rat	1,2,4-trichloro-5-(2,5-dichlorophenyl)benzene	multiple interactions	ISO	RGD:1552470	6480464	[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with more ...	CTD	PMID:25510870
Kifc1	Rat	1,2-dimethylhydrazine	increases expression	ISO	RGD:1552470	6480464	1,2-Dimethylhydrazine results in increased expression of KIFC1 mRNA	CTD	PMID:22206623
Kifc1	Rat	1-chloro-2,4-dinitrobenzene	affects binding	ISO	RGD:1349353	6480464	Dinitrochlorobenzene binds to KIFC1 protein	CTD	PMID:32991956
Kifc1	Rat	1-naphthyl isothiocyanate	increases expression	EXP		6480464	1-Naphthylisothiocyanate results in increased expression of KIFC1 mRNA	CTD	PMID:30723492
Kifc1	Rat	17beta-estradiol	increases expression	ISO	RGD:1349353	6480464	Estradiol results in increased expression of KIFC1 mRNA	CTD	PMID:19167446
Kifc1	Rat	17beta-estradiol	increases expression	ISO	RGD:1552470	6480464	Estradiol results in increased expression of KIFC1 mRNA	CTD	PMID:25210133
Kifc1	Rat	17beta-estradiol	multiple interactions	ISO	RGD:1552470	6480464	ESR1 protein promotes the reaction [Estradiol results in increased expression of KIFC1 mRNA]	CTD	PMID:25210133
Kifc1	Rat	17beta-estradiol	affects expression	EXP		6480464	Estradiol affects the expression of KIFC1 mRNA	CTD	PMID:32145629
Kifc1	Rat	2,2',4,4',5,5'-hexachlorobiphenyl	multiple interactions	ISO	RGD:1552470	6480464	[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with more ...	CTD	PMID:25510870
Kifc1	Rat	2,2',5,5'-tetrachlorobiphenyl	multiple interactions	ISO	RGD:1552470	6480464	[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with more ...	CTD	PMID:25510870
Kifc1	Rat	2,3,7,8-tetrachlorodibenzodioxine	affects expression	EXP		6480464	Tetrachlorodibenzodioxin affects the expression of KIFC1 mRNA	CTD	PMID:22298810
Kifc1	Rat	2,3,7,8-tetrachlorodibenzodioxine	affects expression	ISO	RGD:1552470	6480464	Tetrachlorodibenzodioxin affects the expression of KIFC1 mRNA	CTD	PMID:26377647
Kifc1	Rat	2,3,7,8-tetrachlorodibenzodioxine	decreases expression	EXP		6480464	Tetrachlorodibenzodioxin results in decreased expression of KIFC1 mRNA	CTD	PMID:32109520\|PMID:33387578\|PMID:34747641
Kifc1	Rat	2,4,4'-trichlorobiphenyl	multiple interactions	ISO	RGD:1552470	6480464	[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with more ...	CTD	PMID:25510870
Kifc1	Rat	2-palmitoylglycerol	increases expression	ISO	RGD:1349353	6480464	2-palmitoylglycerol results in increased expression of KIFC1 mRNA	CTD	PMID:37199045
Kifc1	Rat	3,3',4,4',5-pentachlorobiphenyl	increases expression	EXP		6480464	3,4,5,3',4'-pentachlorobiphenyl results in increased expression of KIFC1 mRNA	CTD	PMID:23196670
Kifc1	Rat	4,4'-diaminodiphenylmethane	increases expression	ISO	RGD:1552470	6480464	4,4'-diaminodiphenylmethane results in increased expression of KIFC1 mRNA	CTD	PMID:18648102
Kifc1	Rat	4,4'-sulfonyldiphenol	decreases methylation	ISO	RGD:1349353	6480464	bisphenol S results in decreased methylation of KIFC1 gene	CTD	PMID:31601247
Kifc1	Rat	6-propyl-2-thiouracil	increases expression	EXP		6480464	Propylthiouracil results in increased expression of KIFC1 mRNA	CTD	PMID:24780913
Kifc1	Rat	acetamide	increases expression	EXP		6480464	acetamide results in increased expression of KIFC1 mRNA	CTD	PMID:31881176
Kifc1	Rat	acrylamide	increases expression	EXP		6480464	Acrylamide results in increased expression of KIFC1 mRNA	CTD	PMID:28959563
Kifc1	Rat	acrylamide	decreases expression	ISO	RGD:1349353	6480464	Acrylamide results in decreased expression of KIFC1 mRNA	CTD	PMID:32763439
Kifc1	Rat	aflatoxin B1	increases expression	EXP		6480464	Aflatoxin B1 results in increased expression of KIFC1 mRNA	CTD	PMID:23630614
Kifc1	Rat	all-trans-retinoic acid	decreases expression	ISO	RGD:1349353	6480464	Tretinoin results in decreased expression of KIFC1 mRNA	CTD	PMID:33167477
Kifc1	Rat	amiodarone	increases expression	ISO	RGD:1349353	6480464	Amiodarone results in increased expression of KIFC1 mRNA	CTD	PMID:19774075
Kifc1	Rat	ammonium chloride	affects expression	EXP		6480464	Ammonium Chloride affects the expression of KIFC1 mRNA	CTD	PMID:16483693
Kifc1	Rat	arsane	affects methylation	ISO	RGD:1349353	6480464	Arsenic affects the methylation of KIFC1 gene	CTD	PMID:25304211
Kifc1	Rat	arsane	multiple interactions	ISO	RGD:1349353	6480464	[[sodium arsenite results in increased abundance of Arsenic] co-treated with [manganese chloride results in increased more ...	CTD	PMID:39836092
Kifc1	Rat	arsenic atom	affects methylation	ISO	RGD:1349353	6480464	Arsenic affects the methylation of KIFC1 gene	CTD	PMID:25304211
Kifc1	Rat	arsenic atom	multiple interactions	ISO	RGD:1349353	6480464	[[sodium arsenite results in increased abundance of Arsenic] co-treated with [manganese chloride results in increased more ...	CTD	PMID:39836092
Kifc1	Rat	arsenite(3-)	multiple interactions	ISO	RGD:1349353	6480464	arsenite promotes the reaction [G3BP1 protein binds to KIFC1 mRNA]	CTD	PMID:32406909
Kifc1	Rat	benzene	increases expression	ISO	RGD:1552470	6480464	Benzene results in increased expression of KIFC1 mRNA	CTD	PMID:15120971\|PMID:15122651
Kifc1	Rat	benzo[a]pyrene	decreases expression	ISO	RGD:1349353	6480464	Benzo(a)pyrene results in decreased expression of KIFC1 mRNA	CTD	PMID:20064835
Kifc1	Rat	benzo[a]pyrene	increases expression	ISO	RGD:1552470	6480464	Benzo(a)pyrene results in increased expression of KIFC1 mRNA	CTD	PMID:32417428
Kifc1	Rat	benzo[a]pyrene	affects methylation	ISO	RGD:1349353	6480464	Benzo(a)pyrene affects the methylation of KIFC1 promoter	CTD	PMID:27901495
Kifc1	Rat	benzo[a]pyrene diol epoxide I	decreases expression	ISO	RGD:1349353	6480464	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of KIFC1 mRNA	CTD	PMID:19150397\|PMID:20382639
Kifc1	Rat	benzo[b]fluoranthene	increases expression	ISO	RGD:1552470	6480464	benzo(b)fluoranthene results in increased expression of KIFC1 mRNA	CTD	PMID:26377693
Kifc1	Rat	beta-lapachone	decreases expression	ISO	RGD:1349353	6480464	beta-lapachone results in decreased expression of KIFC1 mRNA	CTD	PMID:38218311
Kifc1	Rat	bis(2-chloroethyl) sulfide	decreases expression	ISO	RGD:1349353	6480464	Mustard Gas results in decreased expression of KIFC1 mRNA	CTD	PMID:25102026
Kifc1	Rat	bisphenol A	affects expression	EXP		6480464	bisphenol A affects the expression of KIFC1 mRNA	CTD	PMID:25181051\|PMID:32145629
Kifc1	Rat	bisphenol A	decreases methylation	ISO	RGD:1349353	6480464	bisphenol A results in decreased methylation of KIFC1 gene	CTD	PMID:31601247
Kifc1	Rat	bisphenol A	decreases expression	EXP		6480464	bisphenol A results in decreased expression of KIFC1 mRNA	CTD	PMID:34947998
Kifc1	Rat	bisphenol A	affects expression	ISO	RGD:1349353	6480464	bisphenol A affects the expression of KIFC1 mRNA	CTD	PMID:30903817
Kifc1	Rat	bisphenol A	decreases expression	ISO	RGD:1349353	6480464	bisphenol A results in decreased expression of KIFC1 mRNA	CTD	PMID:29275510
Kifc1	Rat	bisphenol A	multiple interactions	ISO	RGD:1349353	6480464	[bisphenol A co-treated with Fulvestrant] results in decreased methylation of KIFC1 gene; bisphenol A promotes more ...	CTD	PMID:27156127\|PMID:31601247
Kifc1	Rat	bortezomib	decreases expression	ISO	RGD:1349353	6480464	Bortezomib results in decreased expression of KIFC1 mRNA	CTD	PMID:20977926
Kifc1	Rat	cadmium dichloride	decreases methylation	EXP		6480464	Cadmium Chloride results in decreased methylation of KIFC1 promoter	CTD	PMID:22457795
Kifc1	Rat	cadmium dichloride	increases expression	ISO	RGD:1349353	6480464	Cadmium Chloride results in increased expression of KIFC1 mRNA	CTD	PMID:26472689
Kifc1	Rat	cadmium dichloride	decreases expression	EXP		6480464	Cadmium Chloride results in decreased expression of KIFC1 mRNA	CTD	PMID:25993096
Kifc1	Rat	calcitriol	decreases expression	ISO	RGD:1349353	6480464	Calcitriol results in decreased expression of KIFC1 mRNA	CTD	PMID:21592394
Kifc1	Rat	calcitriol	multiple interactions	ISO	RGD:1349353	6480464	[Testosterone co-treated with Calcitriol] results in decreased expression of KIFC1 mRNA	CTD	PMID:21592394
Kifc1	Rat	carbamazepine	affects expression	ISO	RGD:1349353	6480464	Carbamazepine affects the expression of KIFC1 mRNA	CTD	PMID:25979313
Kifc1	Rat	chlorpyrifos	decreases expression	ISO	RGD:1552470	6480464	Chlorpyrifos results in decreased expression of KIFC1 mRNA	CTD	PMID:37019170
Kifc1	Rat	choline	multiple interactions	ISO	RGD:1552470	6480464	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression more ...	CTD	PMID:20938992
Kifc1	Rat	chromium(6+)	multiple interactions	ISO	RGD:1349353	6480464	[zinc chromate results in increased abundance of chromium hexavalent ion] which results in decreased expression more ...	CTD	PMID:38479592
Kifc1	Rat	chromium(6+)	affects expression	ISO	RGD:1552470	6480464	chromium hexavalent ion affects the expression of KIFC1 mRNA	CTD	PMID:28472532
Kifc1	Rat	cocaine	affects expression	EXP		6480464	Cocaine affects the expression of KIFC1 mRNA	CTD	PMID:20187946
Kifc1	Rat	copper atom	multiple interactions	ISO	RGD:1349353	6480464	[NSC 689534 binds to Copper] which results in decreased expression of KIFC1 mRNA	CTD	PMID:20971185
Kifc1	Rat	copper atom	increases expression	EXP		6480464	Copper results in increased expression of KIFC1 mRNA	CTD	PMID:30556269
Kifc1	Rat	copper(0)	multiple interactions	ISO	RGD:1349353	6480464	[NSC 689534 binds to Copper] which results in decreased expression of KIFC1 mRNA	CTD	PMID:20971185
Kifc1	Rat	copper(0)	increases expression	EXP		6480464	Copper results in increased expression of KIFC1 mRNA	CTD	PMID:30556269
Kifc1	Rat	copper(II) sulfate	decreases expression	ISO	RGD:1349353	6480464	Copper Sulfate results in decreased expression of KIFC1 mRNA	CTD	PMID:19549813
Kifc1	Rat	corticosterone	decreases expression	EXP		6480464	Corticosterone results in decreased expression of KIFC1 mRNA	CTD	PMID:15755911
Kifc1	Rat	coumestrol	multiple interactions	ISO	RGD:1349353	6480464	[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in increased expression of KIFC1 mRNA	CTD	PMID:19167446
Kifc1	Rat	coumestrol	increases expression	ISO	RGD:1349353	6480464	Coumestrol results in increased expression of KIFC1 mRNA	CTD	PMID:19167446
Kifc1	Rat	crocidolite asbestos	increases methylation	ISO	RGD:1349353	6480464	Asbestos, Crocidolite results in increased methylation of KIFC1 5' UTR	CTD	PMID:29523930
Kifc1	Rat	CU-O LINKAGE	decreases expression	ISO	RGD:1349353	6480464	cupric oxide results in decreased expression of KIFC1 mRNA	CTD	PMID:22077320
Kifc1	Rat	Cuprizon	increases expression	EXP		6480464	Cuprizone results in increased expression of KIFC1 mRNA	CTD	PMID:26577399
Kifc1	Rat	cyclosporin A	decreases expression	EXP		6480464	Cyclosporine results in decreased expression of KIFC1 mRNA	CTD	PMID:21865292
Kifc1	Rat	cyclosporin A	decreases expression	ISO	RGD:1349353	6480464	Cyclosporine results in decreased expression of KIFC1 mRNA	CTD	PMID:19159671\|PMID:25562108
Kifc1	Rat	DDE	increases expression	ISO	RGD:1349353	6480464	Dichlorodiphenyl Dichloroethylene results in increased expression of KIFC1 mRNA	CTD	PMID:38568856
Kifc1	Rat	diallyl trisulfide	decreases expression	ISO	RGD:1349353	6480464	diallyl trisulfide results in decreased expression of KIFC1 mRNA	CTD	PMID:34995734
Kifc1	Rat	dibenz[a,h]anthracene	increases expression	ISO	RGD:1552470	6480464	1,2,5,6-dibenzanthracene results in increased expression of KIFC1 mRNA	CTD	PMID:26377693
Kifc1	Rat	dibutyl phthalate	decreases expression	EXP		6480464	Dibutyl Phthalate results in decreased expression of KIFC1 mRNA	CTD	PMID:21266533
Kifc1	Rat	diethyl maleate	increases expression	EXP		6480464	diethyl maleate results in increased expression of KIFC1 mRNA	CTD	PMID:21161181
Kifc1	Rat	dioxygen	decreases expression	ISO	RGD:1349353	6480464	Oxygen deficiency results in decreased expression of KIFC1 mRNA	CTD	PMID:26516004
Kifc1	Rat	doxorubicin	decreases expression	ISO	RGD:1349353	6480464	Doxorubicin results in decreased expression of KIFC1 mRNA	CTD	PMID:30031762
Kifc1	Rat	endosulfan	increases expression	EXP		6480464	Endosulfan results in increased expression of KIFC1 mRNA	CTD	PMID:29391264
Kifc1	Rat	Enterolactone	multiple interactions	ISO	RGD:1349353	6480464	[Coumestrol co-treated with 2,3-bis(3'-hydroxybenzyl)butyrolactone] results in increased expression of KIFC1 mRNA	CTD	PMID:19167446
Kifc1	Rat	fenofibrate	increases expression	EXP		6480464	Fenofibrate results in increased expression of KIFC1 mRNA	CTD	PMID:32741897
Kifc1	Rat	folic acid	multiple interactions	ISO	RGD:1349353	6480464	[Folic Acid deficiency co-treated with Methotrexate] results in decreased expression of KIFC1 mRNA	CTD	PMID:24657277
Kifc1	Rat	folic acid	decreases expression	ISO	RGD:1552470	6480464	Folic Acid results in decreased expression of KIFC1 mRNA	CTD	PMID:25629700
Kifc1	Rat	folic acid	multiple interactions	ISO	RGD:1552470	6480464	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression more ...	CTD	PMID:20938992
Kifc1	Rat	FR900359	affects phosphorylation	ISO	RGD:1349353	6480464	FR900359 affects the phosphorylation of KIFC1 protein	CTD	PMID:37730182
Kifc1	Rat	fulvestrant	multiple interactions	ISO	RGD:1349353	6480464	[bisphenol A co-treated with Fulvestrant] results in decreased methylation of KIFC1 gene	CTD	PMID:31601247
Kifc1	Rat	gentamycin	decreases expression	EXP		6480464	Gentamicins results in decreased expression of KIFC1 mRNA	CTD	PMID:33387578
Kifc1	Rat	hydrogen peroxide	affects expression	ISO	RGD:1349353	6480464	Hydrogen Peroxide affects the expression of KIFC1 mRNA	CTD	PMID:21179406
Kifc1	Rat	ivermectin	decreases expression	ISO	RGD:1349353	6480464	Ivermectin results in decreased expression of KIFC1 protein	CTD	PMID:32959892
Kifc1	Rat	L-methionine	multiple interactions	ISO	RGD:1552470	6480464	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression more ...	CTD	PMID:20938992
Kifc1	Rat	lead(0)	affects expression	ISO	RGD:1349353	6480464	Lead affects the expression of KIFC1 mRNA	CTD	PMID:28903495
Kifc1	Rat	leflunomide	decreases expression	ISO	RGD:1349353	6480464	leflunomide results in decreased expression of KIFC1 mRNA	CTD	PMID:28988120
Kifc1	Rat	lidocaine	increases expression	EXP		6480464	Lidocaine results in increased expression of KIFC1 mRNA	CTD	PMID:35283115
Kifc1	Rat	linezolid	decreases expression	EXP		6480464	Linezolid results in decreased expression of KIFC1 mRNA	CTD	PMID:21296123
Kifc1	Rat	lithium atom	increases expression	EXP		6480464	Lithium results in increased expression of KIFC1 mRNA	CTD	PMID:21711903
Kifc1	Rat	lithium hydride	increases expression	EXP		6480464	Lithium results in increased expression of KIFC1 mRNA	CTD	PMID:21711903
Kifc1	Rat	lucanthone	decreases expression	ISO	RGD:1349353	6480464	Lucanthone results in decreased expression of KIFC1 mRNA	CTD	PMID:21148553
Kifc1	Rat	manganese atom	multiple interactions	ISO	RGD:1349353	6480464	[[sodium arsenite results in increased abundance of Arsenic] co-treated with [manganese chloride results in increased more ...	CTD	PMID:39836092
Kifc1	Rat	manganese(0)	multiple interactions	ISO	RGD:1349353	6480464	[[sodium arsenite results in increased abundance of Arsenic] co-treated with [manganese chloride results in increased more ...	CTD	PMID:39836092
Kifc1	Rat	manganese(II) chloride	multiple interactions	ISO	RGD:1349353	6480464	[[sodium arsenite results in increased abundance of Arsenic] co-treated with [manganese chloride results in increased more ...	CTD	PMID:39836092
Kifc1	Rat	MeIQx	decreases expression	ISO	RGD:1349353	6480464	2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline results in decreased expression of KIFC1 mRNA	CTD	PMID:20816883
Kifc1	Rat	mercury dichloride	decreases expression	EXP		6480464	Mercuric Chloride results in decreased expression of KIFC1 mRNA	CTD	PMID:16507785
Kifc1	Rat	methamphetamine	decreases expression	ISO	RGD:1349353	6480464	Methamphetamine results in decreased expression of KIFC1 mRNA	CTD	PMID:25290377
Kifc1	Rat	methapyrilene	increases expression	EXP		6480464	Methapyrilene results in increased expression of KIFC1 mRNA	CTD	PMID:22484513
Kifc1	Rat	methotrexate	multiple interactions	ISO	RGD:1349353	6480464	[Folic Acid deficiency co-treated with Methotrexate] results in decreased expression of KIFC1 mRNA	CTD	PMID:24657277
Kifc1	Rat	methotrexate	decreases expression	ISO	RGD:1349353	6480464	Methotrexate results in decreased expression of KIFC1 mRNA	CTD	PMID:24657277
Kifc1	Rat	N-methyl-4-phenylpyridinium	decreases expression	ISO	RGD:1349353	6480464	1-Methyl-4-phenylpyridinium results in decreased expression of KIFC1 mRNA	CTD	PMID:24810058
Kifc1	Rat	N-Nitrosopyrrolidine	decreases expression	ISO	RGD:1349353	6480464	N-Nitrosopyrrolidine results in decreased expression of KIFC1 mRNA	CTD	PMID:32234424
Kifc1	Rat	niclosamide	decreases expression	ISO	RGD:1349353	6480464	Niclosamide results in decreased expression of KIFC1 mRNA	CTD	PMID:28284560
Kifc1	Rat	okadaic acid	increases expression	ISO	RGD:1349353	6480464	Okadaic Acid results in increased expression of KIFC1 mRNA	CTD	PMID:38832940
Kifc1	Rat	oxaliplatin	multiple interactions	EXP		6480464	[oxaliplatin co-treated with Topotecan] results in decreased expression of KIFC1 mRNA	CTD	PMID:25729387
Kifc1	Rat	oxaliplatin	decreases expression	EXP		6480464	oxaliplatin results in decreased expression of KIFC1 mRNA	CTD	PMID:25729387
Kifc1	Rat	ozone	multiple interactions	ISO	RGD:1552470	6480464	[Air Pollutants results in increased abundance of [Ozone co-treated with Soot]] which results in increased more ...	CTD	PMID:25658374\|PMID:27106289\|PMID:34911549
Kifc1	Rat	ozone	increases expression	ISO	RGD:1552470	6480464	Ozone results in increased expression of KIFC1 mRNA	CTD	PMID:33026818
Kifc1	Rat	palbociclib	decreases expression	ISO	RGD:1349353	6480464	palbociclib results in decreased expression of KIFC1 mRNA	CTD	PMID:22869556
Kifc1	Rat	paracetamol	increases expression	ISO	RGD:1349353	6480464	Acetaminophen results in increased expression of KIFC1 mRNA	CTD	PMID:22230336
Kifc1	Rat	paracetamol	decreases expression	EXP		6480464	Acetaminophen results in decreased expression of KIFC1 mRNA	CTD	PMID:33387578
Kifc1	Rat	paracetamol	decreases expression	ISO	RGD:1349353	6480464	Acetaminophen results in decreased expression of KIFC1 mRNA	CTD	PMID:29067470
Kifc1	Rat	PCB138	multiple interactions	ISO	RGD:1552470	6480464	[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with more ...	CTD	PMID:25510870
Kifc1	Rat	perfluorohexanesulfonic acid	decreases expression	ISO	RGD:1552470	6480464	perfluorohexanesulfonic acid results in decreased expression of KIFC1 mRNA	CTD	PMID:37995155
Kifc1	Rat	perfluorooctanoic acid	decreases expression	ISO	RGD:1349353	6480464	perfluorooctanoic acid results in decreased expression of KIFC1 mRNA	CTD	PMID:36326898
Kifc1	Rat	phenanthridone	increases metabolic processing	ISO	RGD:1349353	6480464	phenanthridone results in increased metabolism of KIFC1 protein	CTD	PMID:28209915
Kifc1	Rat	pirinixic acid	increases expression	EXP		6480464	pirinixic acid results in increased expression of KIFC1 mRNA	CTD	PMID:12832660
Kifc1	Rat	potassium dichromate	increases expression	ISO	RGD:1349353	6480464	Potassium Dichromate results in increased expression of KIFC1 protein	CTD	PMID:23718831
Kifc1	Rat	pregnenolone 16alpha-carbonitrile	increases expression	ISO	RGD:1552470	6480464	Pregnenolone Carbonitrile results in increased expression of KIFC1 mRNA	CTD	PMID:22698814
Kifc1	Rat	propanal	decreases expression	ISO	RGD:1349353	6480464	propionaldehyde results in decreased expression of KIFC1 mRNA	CTD	PMID:26079696
Kifc1	Rat	quercetin	increases expression	EXP		6480464	Quercetin results in increased expression of KIFC1 mRNA	CTD	PMID:18095365
Kifc1	Rat	silicon dioxide	increases expression	ISO	RGD:1552470	6480464	Silicon Dioxide results in increased expression of KIFC1 mRNA	CTD	PMID:29341224
Kifc1	Rat	sirolimus	decreases expression	EXP		6480464	Sirolimus results in decreased expression of KIFC1 mRNA	CTD	PMID:21865292
Kifc1	Rat	sodium arsenite	affects expression	ISO	RGD:1349353	6480464	sodium arsenite affects the expression of KIFC1 mRNA	CTD	PMID:29301061
Kifc1	Rat	sodium arsenite	multiple interactions	ISO	RGD:1349353	6480464	[[sodium arsenite results in increased abundance of Arsenic] co-treated with [manganese chloride results in increased more ...	CTD	PMID:39836092
Kifc1	Rat	sodium arsenite	increases expression	ISO	RGD:1349353	6480464	sodium arsenite results in increased expression of KIFC1 mRNA	CTD	PMID:34032870
Kifc1	Rat	sodium arsenite	decreases expression	ISO	RGD:1349353	6480464	sodium arsenite results in decreased expression of KIFC1 mRNA	CTD	PMID:38568856
Kifc1	Rat	sunitinib	decreases expression	ISO	RGD:1349353	6480464	Sunitinib results in decreased expression of KIFC1 mRNA	CTD	PMID:31533062
Kifc1	Rat	tacrolimus hydrate	decreases expression	EXP		6480464	Tacrolimus results in decreased expression of KIFC1 mRNA	CTD	PMID:21865292
Kifc1	Rat	temozolomide	increases expression	ISO	RGD:1349353	6480464	Temozolomide results in increased expression of KIFC1 mRNA	CTD	PMID:31758290
Kifc1	Rat	tert-butyl hydroperoxide	decreases expression	ISO	RGD:1349353	6480464	tert-Butylhydroperoxide results in decreased expression of KIFC1 mRNA	CTD	PMID:15336504
Kifc1	Rat	testosterone	multiple interactions	ISO	RGD:1349353	6480464	[Testosterone co-treated with Calcitriol] results in decreased expression of KIFC1 mRNA	CTD	PMID:21592394
Kifc1	Rat	testosterone	decreases expression	ISO	RGD:1552470	6480464	Testosterone deficiency results in decreased expression of KIFC1 mRNA	CTD	PMID:33848595
Kifc1	Rat	testosterone	decreases expression	ISO	RGD:1349353	6480464	Testosterone results in decreased expression of KIFC1 mRNA	CTD	PMID:21592394
Kifc1	Rat	thapsigargin	decreases expression	EXP		6480464	Thapsigargin results in decreased expression of KIFC1 protein	CTD	PMID:35544339
Kifc1	Rat	thioacetamide	increases expression	EXP		6480464	Thioacetamide results in increased expression of KIFC1 mRNA	CTD	PMID:23411599\|PMID:34492290
Kifc1	Rat	thiram	decreases expression	ISO	RGD:1349353	6480464	Thiram results in decreased expression of KIFC1 mRNA	CTD	PMID:38568856
Kifc1	Rat	titanium dioxide	increases expression	EXP		6480464	titanium dioxide results in increased expression of KIFC1 mRNA	CTD	PMID:30012374
Kifc1	Rat	titanium dioxide	increases methylation	ISO	RGD:1552470	6480464	titanium dioxide results in increased methylation of KIFC1 gene	CTD	PMID:35295148
Kifc1	Rat	topotecan	decreases expression	EXP		6480464	Topotecan results in decreased expression of KIFC1 mRNA	CTD	PMID:25729387
Kifc1	Rat	topotecan	multiple interactions	EXP		6480464	[oxaliplatin co-treated with Topotecan] results in decreased expression of KIFC1 mRNA	CTD	PMID:25729387
Kifc1	Rat	trichloroethene	decreases expression	EXP		6480464	Trichloroethylene results in decreased expression of KIFC1 mRNA	CTD	PMID:33387578
Kifc1	Rat	trimellitic anhydride	increases expression	ISO	RGD:1552470	6480464	trimellitic anhydride results in increased expression of KIFC1 mRNA	CTD	PMID:19042947
Kifc1	Rat	triptonide	increases expression	ISO	RGD:1552470	6480464	triptonide results in increased expression of KIFC1 mRNA	CTD	PMID:33045310
Kifc1	Rat	tunicamycin	decreases expression	ISO	RGD:1349353	6480464	Tunicamycin results in decreased expression of KIFC1 mRNA	CTD	PMID:29453283
Kifc1	Rat	valproic acid	increases methylation	ISO	RGD:1349353	6480464	Valproic Acid results in increased methylation of KIFC1 gene	CTD	PMID:29154799
Kifc1	Rat	valproic acid	decreases expression	ISO	RGD:1349353	6480464	Valproic Acid results in decreased expression of KIFC1 mRNA	CTD	PMID:37505509
Kifc1	Rat	zoledronic acid	decreases expression	ISO	RGD:1349353	6480464	zoledronic acid results in decreased expression of KIFC1 mRNA	CTD	PMID:24714768

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Kifc1	Rat	cell division	involved_in	IEA	UniProtKB-KW:KW-0132	1600115	GO_REF:0000043	UniProt	GO_REF:0000043
Kifc1	Rat	microtubule-based movement	involved_in	IEA	InterPro:IPR001752\|InterPro:IPR019821\|InterPro:IPR027640	1600115	GO_REF:0000002	InterPro	GO_REF:0000002
Kifc1	Rat	microtubule-based movement	involved_in	IBA	FB:FBgn0000352\|FB:FBgn0001308\|FB:FBgn0004379\|FB:FBgn0004380\|FB:FBgn0004381\|FB:FBgn0004387\|FB:FBgn0011692\|FB:FBgn0034827\|FB:FBgn0267002\|MGI:107688\|MGI:107689\|MGI:108390\|MGI:108391\|MGI:108426\|MGI:109234\|MGI:109564\|MGI:109596\|MGI:1098229\|MGI:1098264\|MGI:1098268\|MGI:1098269\|MGI:1922300\|PANTHER:PTN000648413\|PomBase:SPAC3A11.14c\|PomBase:SPAC664.10\|PomBase:SPBC1685.15c\|PomBase:SPBC2F12.13\|RGD:1303035\|RGD:1304996\|RGD:1305126\|RGD:1559696\|RGD:621520\|RGD:621559\|RGD:70928\|RGD:70974\|SGD:S000003184\|SGD:S000006076\|TAIR:locus:2129630\|TAIR:locus:2152059\|UniProtKB:A0A8M9PLX5\|UniProtKB:A8BB91\|UniProtKB:O15066\|UniProtKB:O60333\|UniProtKB:P33176\|UniProtKB:Q5AVY3\|UniProtKB:Q6YZ52\|WB:WBGene00002222\|WB:WBGene00002225\|WB:WBGene00002230\|WB:WBGene00003884\|WB:WBGene00006831\|WB:WBGene00006840\|WB:WBGene00006974\|ZFIN:ZDB-GENE-070912-141\|dictyBase:DDB_G0281555\|dictyBase:DDB_G0290963	1600115	GO_REF:0000033	GO_Central	GO_REF:0000033
Kifc1	Rat	minus-end-directed vesicle transport along microtubule	acts_upstream_of_or_within	ISO	RGD:1552470	1624291	PMID:17360972	RGD	PMID:17360972
Kifc1	Rat	mitotic metaphase chromosome alignment	involved_in	ISS	UniProtKB:Q9BW19	1600115	GO_REF:0000024	UniProt	GO_REF:0000024
Kifc1	Rat	mitotic metaphase chromosome alignment	involved_in	ISO	RGD:1349353	1624291	PMID:15843429	RGD	PMID:15843429
Kifc1	Rat	mitotic metaphase chromosome alignment	involved_in	IEA	UniProtKB:Q9BW19\|ensembl:ENSP00000393963	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Kifc1	Rat	mitotic spindle assembly	involved_in	ISS	UniProtKB:Q9BW19	1600115	GO_REF:0000024	UniProt	GO_REF:0000024
Kifc1	Rat	mitotic spindle assembly	involved_in	IBA	PANTHER:PTN001537590\|PomBase:SPAC3A11.14c\|PomBase:SPAC664.10\|UniProtKB:P28739\|UniProtKB:Q9BW19	1600115	GO_REF:0000033	GO_Central	GO_REF:0000033
Kifc1	Rat	mitotic spindle assembly	involved_in	ISO	RGD:1349353	1624291	PMID:15843429	RGD	PMID:15843429
Kifc1	Rat	mitotic spindle assembly	involved_in	IEA	UniProtKB:Q9BW19\|ensembl:ENSP00000393963	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Kifc1	Rat	negative regulation of centrosome duplication	acts_upstream_of_or_within	ISO	RGD:1552470	1624291	PMID:16638812	RGD	PMID:16638812
Kifc1	Rat	spermatogenesis		IEP		9831193		RGD
Kifc1	Rat	vesicle transport along microtubule	acts_upstream_of_or_within	ISO	RGD:1552470	1624291	MGI:1098268 PMID:17360972	RGD	PMID:17360972

Cellular Component

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Kifc1	Rat	centrosome	located_in	IEA	UniProtKB-SubCell:SL-0048	1600115	GO_REF:0000044	UniProt	GO_REF:0000044
Kifc1	Rat	cytoplasm	is_active_in	IBA	FB:FBgn0001308\|FB:FBgn0004380\|FB:FBgn0004387\|FB:FBgn0030268\|MGI:108426\|MGI:109234\|MGI:109564\|MGI:109596\|MGI:1098229\|MGI:1098240\|MGI:1098260\|MGI:1098264\|MGI:1098269\|MGI:2444576\|PANTHER:PTN000648413\|PomBase:SPAC144.14\|PomBase:SPAC1834.07\|PomBase:SPAC664.10\|PomBase:SPBC1685.15c\|PomBase:SPBC2F12.13\|RGD:1303035\|RGD:1303307\|RGD:621536\|RGD:621538\|SGD:S000003184\|SGD:S000006076\|TAIR:locus:2088065\|TAIR:locus:2127378\|TAIR:locus:2129630\|TAIR:locus:2152059\|UniProtKB:A0A8M9PLX5\|UniProtKB:A8BB91\|UniProtKB:C8V3Q8\|UniProtKB:D6XFK9\|UniProtKB:O00139\|UniProtKB:P33176\|UniProtKB:Q14807\|UniProtKB:Q57UD0\|UniProtKB:Q57UV7\|UniProtKB:Q57UW8\|UniProtKB:Q57V46\|UniProtKB:Q57V47\|UniProtKB:Q57VI2\|UniProtKB:Q57X99\|UniProtKB:Q57XT2\|UniProtKB:Q57YB0\|UniProtKB:Q583P6\|UniProtKB:Q5AVY3\|UniProtKB:Q86Y91\|UniProtKB:Q9H1H9\|UniProtKB:Q9NQT8\|WB:WBGene00002217\|WB:WBGene00002222\|WB:WBGene00002230\|WB:WBGene00003884\|WB:WBGene00006840\|ZFIN:ZDB-GENE-050307-1\|dictyBase:DDB_G0281555\|dictyBase:DDB_G0293198	1600115	GO_REF:0000033	GO_Central	GO_REF:0000033
Kifc1	Rat	cytoplasm	located_in	IEA	UniProtKB-KW:KW-0963	1600115	GO_REF:0000043	UniProt	GO_REF:0000043
Kifc1	Rat	cytoskeleton	located_in	IEA	UniProtKB-KW:KW-0206	1600115	GO_REF:0000043	UniProt	GO_REF:0000043
Kifc1	Rat	cytoskeleton	located_in	IEA	UniProtKB-SubCell:SL-0090	1600115	GO_REF:0000044	UniProt	GO_REF:0000044
Kifc1	Rat	early endosome	located_in	IEA	UniProtKB-SubCell:SL-0094	1600115	GO_REF:0000044	UniProt	GO_REF:0000044
Kifc1	Rat	endocytic vesicle	located_in	ISO	RGD:1552470	1624291	PMID:17360972	RGD	PMID:17360972
Kifc1	Rat	endosome	located_in	IEA	UniProtKB-KW:KW-0967	1600115	GO_REF:0000043	UniProt	GO_REF:0000043
Kifc1	Rat	kinesin complex	part_of	IBA	FB:FBgn0001308\|FB:FBgn0002948\|MGI:107688\|MGI:107689\|MGI:1098229\|PANTHER:PTN000648413\|PomBase:SPAC664.10\|PomBase:SPBC1685.15c\|PomBase:SPBC2F12.13\|RGD:1303035\|UniProtKB:D6XFK9\|UniProtKB:O15066\|UniProtKB:Q57UV7\|UniProtKB:Q57UW8\|UniProtKB:Q57X99\|UniProtKB:Q57XC6\|UniProtKB:Q9Y496\|WB:WBGene00003884\|WB:WBGene00006840\|ZFIN:ZDB-GENE-050119-3\|ZFIN:ZDB-GENE-050417-71\|ZFIN:ZDB-GENE-080724-12	1600115	GO_REF:0000033	GO_Central	GO_REF:0000033
Kifc1	Rat	microtubule	located_in	IEA	UniProtKB-KW:KW-0493	1600115	GO_REF:0000043	UniProt	GO_REF:0000043
Kifc1	Rat	microtubule	is_active_in	IBA	FB:FBgn0001308\|FB:FBgn0003545\|FB:FBgn0004379\|FB:FBgn0011692\|FB:FBgn0019968\|FB:FBgn0030268\|FB:FBgn0034824\|PANTHER:PTN000648413\|PomBase:SPAC1834.07\|PomBase:SPAC664.10\|PomBase:SPBC1685.15c\|PomBase:SPBC2F12.13\|RGD:1303035\|RGD:1304996\|RGD:621538\|SGD:S000003184\|SGD:S000006076\|TAIR:locus:2082697\|TAIR:locus:2115713\|TAIR:locus:2152059\|UniProtKB:A0A1U8MSB6\|UniProtKB:A0A8M9PLX5\|UniProtKB:C8V3Q8\|UniProtKB:G5EAS6\|UniProtKB:O00139\|UniProtKB:Q15058\|UniProtKB:Q5AVY3\|UniProtKB:Q86Y91\|UniProtKB:Q8NI77\|UniProtKB:Q99661\|UniProtKB:Q9HAQ2\|UniProtKB:Q9Y496\|WB:WBGene00002217\|WB:WBGene00002228\|dictyBase:DDB_G0291039\|dictyBase:DDB_G0293198	1600115	GO_REF:0000033	GO_Central	GO_REF:0000033
Kifc1	Rat	microtubule organizing center	is_active_in	IBA	CGD:CAL0000174788\|MGI:109596\|PANTHER:PTN001537590\|PomBase:SPAC3A11.14c	1600115	GO_REF:0000033	GO_Central	GO_REF:0000033
Kifc1	Rat	mitotic spindle	is_active_in	IBA	MGI:109596\|PANTHER:PTN001537590\|PomBase:SPAC3A11.14c\|PomBase:SPAC664.10\|dictyBase:DDB_G0267396	1600115	GO_REF:0000033	GO_Central	GO_REF:0000033
Kifc1	Rat	mitotic spindle	located_in	ISO	RGD:1552470	1624291	PMID:16638812	RGD	PMID:16638812
Kifc1	Rat	nucleus	located_in	IEA	UniProtKB-SubCell:SL-0191	1600115	GO_REF:0000044	UniProt	GO_REF:0000044
Kifc1	Rat	nucleus	located_in	IEA	UniProtKB-KW:KW-0539	1600115	GO_REF:0000043	UniProt	GO_REF:0000043
Kifc1	Rat	nucleus	is_active_in	IBA	MGI:109596\|PANTHER:PTN001537590\|PomBase:SPAC3A11.14c\|PomBase:SPAC664.10\|dictyBase:DDB_G0267396	1600115	GO_REF:0000033	GO_Central	GO_REF:0000033
Kifc1	Rat	nucleus	located_in	ISO	RGD:1552470	1624291	PMID:16638812	RGD	PMID:16638812
Kifc1	Rat	spindle	located_in	IEA	UniProtKB-SubCell:SL-0251	1600115	GO_REF:0000044	UniProt	GO_REF:0000044
Kifc1	Rat	spindle pole centrosome	located_in	ISO	RGD:1552470	1624291	PMID:16638812	RGD	PMID:16638812

Molecular Function

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Kifc1	Rat	ATP binding	enables	IEA	UniRule:UR000401007	1600115	GO_REF:0000104	UniProt	GO_REF:0000104
Kifc1	Rat	ATP binding	enables	IEA	InterPro:IPR001752\|InterPro:IPR019821	1600115	GO_REF:0000002	InterPro	GO_REF:0000002
Kifc1	Rat	ATP binding	enables	IEA	UniProtKB-KW:KW-0067	1600115	GO_REF:0000043	UniProt	GO_REF:0000043
Kifc1	Rat	ATP hydrolysis activity	enables	IBA	MGI:1098226\|PANTHER:PTN000648413\|PomBase:SPBC1685.15c\|PomBase:SPBC2F12.13\|RGD:621520\|TAIR:locus:2152059\|TAIR:locus:2157533\|UniProtKB:C8V3Q8\|UniProtKB:O97277\|UniProtKB:Q57XC6\|UniProtKB:Q6YZ52\|UniProtKB:Q96Q89	1600115	GO_REF:0000033	GO_Central	GO_REF:0000033
Kifc1	Rat	cytoskeletal motor activity	enables	IEA	UniRule:UR000401007	1600115	GO_REF:0000104	UniProt	GO_REF:0000104
Kifc1	Rat	microtubule binding	enables	IEA	InterPro:IPR001752	1600115	GO_REF:0000002	InterPro	GO_REF:0000002
Kifc1	Rat	microtubule binding	enables	IBA	FB:FBgn0000352\|FB:FBgn0001308\|FB:FBgn0002948\|MGI:107689\|MGI:108391\|MGI:109564\|MGI:1098226\|PANTHER:PTN000648413\|PomBase:SPAC3A11.14c\|PomBase:SPAC664.10\|PomBase:SPBC1685.15c\|PomBase:SPBC2F12.13\|RGD:1304996\|RGD:1306815\|RGD:621538\|RGD:621559\|TAIR:locus:2082697\|TAIR:locus:2129630\|TAIR:locus:2136437\|TAIR:locus:2152059\|TAIR:locus:2157533\|UniProtKB:C8V3Q8\|UniProtKB:O00139\|UniProtKB:P33176\|UniProtKB:P48467\|UniProtKB:Q02241\|UniProtKB:Q57XC6\|UniProtKB:Q8NI77\|UniProtKB:Q96Q89\|UniProtKB:Q99661\|WB:WBGene00006831\|WB:WBGene00006974\|dictyBase:DDB_G0267396\|dictyBase:DDB_G0274603\|dictyBase:DDB_G0293198	1600115	GO_REF:0000033	GO_Central	GO_REF:0000033
Kifc1	Rat	microtubule motor activity	enables	IEA	InterPro:IPR001752\|InterPro:IPR019821\|InterPro:IPR027640	1600115	GO_REF:0000002	InterPro	GO_REF:0000002
Kifc1	Rat	microtubule motor activity	enables	IBA	FB:FBgn0001308\|FB:FBgn0002948\|FB:FBgn0003545\|FB:FBgn0004380\|FB:FBgn0004387\|FB:FBgn0019968\|FB:FBgn0030268\|MGI:108426\|MGI:109596\|MGI:1098226\|MGI:1098229\|MGI:1098264\|MGI:2447024\|PANTHER:PTN000648413\|PomBase:SPAC3A11.14c\|PomBase:SPAC664.10\|PomBase:SPBC15D4.01c\|PomBase:SPBC1685.15c\|PomBase:SPBC2F12.13\|RGD:621520\|RGD:621559\|SGD:S000003184\|SGD:S000006076\|TAIR:locus:2088065\|TAIR:locus:2115713\|TAIR:locus:2127378\|TAIR:locus:2129455\|TAIR:locus:2129630\|TAIR:locus:2152059\|UniProtKB:C8V3Q8\|UniProtKB:G5EAS6\|UniProtKB:O60333\|UniProtKB:P28739\|UniProtKB:P33176\|UniProtKB:Q2M1P5\|UniProtKB:Q6YZ52\|UniProtKB:Q7Z4S6\|UniProtKB:Q8NI77\|UniProtKB:Q96L93\|UniProtKB:Q96Q89\|WB:WBGene00002222\|WB:WBGene00002225\|WB:WBGene00002230\|WB:WBGene00003884\|WB:WBGene00006831\|WB:WBGene00006840\|WB:WBGene00006974\|dictyBase:DDB_G0267396\|dictyBase:DDB_G0280967\|dictyBase:DDB_G0281555\|dictyBase:DDB_G0290963\|dictyBase:DDB_G0291039\|dictyBase:DDB_G0293198	1600115	GO_REF:0000033	GO_Central	GO_REF:0000033
Kifc1	Rat	minus-end-directed microtubule motor activity	enables	ISO	RGD:1552470	1624291	PMID:16638812	RGD	PMID:16638812
Kifc1	Rat	nucleotide binding	enables	IEA	UniProtKB-KW:KW-0547	1600115	GO_REF:0000043	UniProt	GO_REF:0000043
Kifc1	Rat	nucleotide binding	enables	IEA	UniRule:UR000401007	1600115	GO_REF:0000104	UniProt	GO_REF:0000104
Kifc1	Rat	protein binding		IPI	RGD:2909	9831193		RGD
Kifc1	Rat	protein binding	enables	ISO	RGD:1552470	1624291	PR:Q61768\|PR:Q9R060\|PR:Q9R061\|UniProtKB:Q8R1Z4 PMID:16638812, PMID:17360972, PMID:18237440	RGD	PMID:16638812\|PMID:17360972\|PMID:18237440
Kifc1	Rat	protein binding		IPI	RGD:619938	9831193		RGD

Disease Annotations Click to see Annotation Detail View

autism spectrum disorder (ISO)

autosomal dominant intellectual developmental disorder 5 (ISO)

COVID-19 (ISO)

hepatocellular carcinoma (ISO)

MHC class I deficiency (ISO)

proteasome-associated autoinflammatory syndrome 1 (ISO)

Triple Negative Breast Neoplasms (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1,2,4-trichloro-5-(2,5-dichlorophenyl)benzene (ISO)

1,2-dimethylhydrazine (ISO)

1-chloro-2,4-dinitrobenzene (ISO)

1-naphthyl isothiocyanate (EXP)

17beta-estradiol (EXP,ISO)

2,2',4,4',5,5'-hexachlorobiphenyl (ISO)

2,2',5,5'-tetrachlorobiphenyl (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2,4,4'-trichlorobiphenyl (ISO)

2-palmitoylglycerol (ISO)

3,3',4,4',5-pentachlorobiphenyl (EXP)

4,4'-diaminodiphenylmethane (ISO)

4,4'-sulfonyldiphenol (ISO)

6-propyl-2-thiouracil (EXP)

acetamide (EXP)

acrylamide (EXP,ISO)

aflatoxin B1 (EXP)

all-trans-retinoic acid (ISO)

amiodarone (ISO)

ammonium chloride (EXP)

arsane (ISO)

arsenic atom (ISO)

arsenite(3-) (ISO)

benzene (ISO)

benzo[a]pyrene (ISO)

benzo[a]pyrene diol epoxide I (ISO)

benzo[b]fluoranthene (ISO)

beta-lapachone (ISO)

bis(2-chloroethyl) sulfide (ISO)

bisphenol A (EXP,ISO)

bortezomib (ISO)

cadmium dichloride (EXP,ISO)

calcitriol (ISO)

carbamazepine (ISO)

chlorpyrifos (ISO)

choline (ISO)

chromium(6+) (ISO)

cocaine (EXP)

copper atom (EXP,ISO)

copper(0) (EXP,ISO)

copper(II) sulfate (ISO)

corticosterone (EXP)

coumestrol (ISO)

crocidolite asbestos (ISO)

CU-O LINKAGE (ISO)

Cuprizon (EXP)

cyclosporin A (EXP,ISO)

DDE (ISO)

diallyl trisulfide (ISO)

dibenz[a,h]anthracene (ISO)

dibutyl phthalate (EXP)

diethyl maleate (EXP)

dioxygen (ISO)

doxorubicin (ISO)

endosulfan (EXP)

Enterolactone (ISO)

fenofibrate (EXP)

folic acid (ISO)

FR900359 (ISO)

fulvestrant (ISO)

gentamycin (EXP)

hydrogen peroxide (ISO)

ivermectin (ISO)

L-methionine (ISO)

lead(0) (ISO)

leflunomide (ISO)

lidocaine (EXP)

linezolid (EXP)

lithium atom (EXP)

lithium hydride (EXP)

lucanthone (ISO)

manganese atom (ISO)

manganese(0) (ISO)

manganese(II) chloride (ISO)

MeIQx (ISO)

mercury dichloride (EXP)

methamphetamine (ISO)

methapyrilene (EXP)

methotrexate (ISO)

N-methyl-4-phenylpyridinium (ISO)

N-Nitrosopyrrolidine (ISO)

niclosamide (ISO)

okadaic acid (ISO)

oxaliplatin (EXP)

ozone (ISO)

palbociclib (ISO)

paracetamol (EXP,ISO)

PCB138 (ISO)

perfluorohexanesulfonic acid (ISO)

perfluorooctanoic acid (ISO)

phenanthridone (ISO)

pirinixic acid (EXP)

potassium dichromate (ISO)

pregnenolone 16alpha-carbonitrile (ISO)

propanal (ISO)

quercetin (EXP)

silicon dioxide (ISO)

sirolimus (EXP)

sodium arsenite (ISO)

sunitinib (ISO)

tacrolimus hydrate (EXP)

temozolomide (ISO)

tert-butyl hydroperoxide (ISO)

testosterone (ISO)

thapsigargin (EXP)

thioacetamide (EXP)

thiram (ISO)

titanium dioxide (EXP,ISO)

topotecan (EXP)

trichloroethene (EXP)

trimellitic anhydride (ISO)

triptonide (ISO)

tunicamycin (ISO)

valproic acid (ISO)

zoledronic acid (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

cell division (IEA)

microtubule-based movement (IBA,IEA)

minus-end-directed vesicle transport along microtubule (ISO)

mitotic metaphase chromosome alignment (IEA,ISO,ISS)

mitotic spindle assembly (IBA,IEA,ISO,ISS)

negative regulation of centrosome duplication (ISO)

spermatogenesis (IEP)

vesicle transport along microtubule (ISO)

Cellular Component

centrosome (IEA)

cytoplasm (IBA,IEA)

cytoskeleton (IEA)

early endosome (IEA)

endocytic vesicle (ISO)

endosome (IEA)

kinesin complex (IBA)

microtubule (IBA,IEA)

microtubule organizing center (IBA)

mitotic spindle (IBA,ISO)

nucleus (IBA,IEA,ISO)

spindle (IEA)

spindle pole centrosome (ISO)

Molecular Function

ATP binding (IEA)

ATP hydrolysis activity (IBA)

cytoskeletal motor activity (IEA)

microtubule binding (IBA,IEA)

microtubule motor activity (IBA,IEA)

minus-end-directed microtubule motor activity (ISO)

nucleotide binding (IEA)

protein binding (IPI,ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Rat ISS GO annotations from GOA human gene data--August 2006	GOA data from the GO Consortium
3.	GOA pipeline	RGD automated data pipeline
4.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
5.	Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.	Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
6.	C-terminal kinesin motor KIFC1 participates in acrosome biogenesis and vesicle transport.	Yang WX and Sperry AO, Biol Reprod 2003 Nov;69(5):1719-29. Epub 2003 Jun 25.
7.	The molecular motor KIFC1 associates with a complex containing nucleoporin NUP62 that is regulated during development and by the small GTPase RAN.	Yang WX, etal., Biol Reprod. 2006 Apr;74(4):684-90. Epub 2005 Dec 21.

Additional References at PubMed

PMID:8688559	PMID:15843429	PMID:19946888	PMID:30804089

Genomics

Comparative Map Data

Kifc1
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	20	5,000,929 - 5,018,967 (+)	NCBI		GRCr8
mRatBN7.2	20	4,998,832 - 5,017,107 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	20	4,999,047 - 5,017,105 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	20	5,722,546 - 5,742,381 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	20	5,084,291 - 5,104,118 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	20	5,564,478 - 5,582,550 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	20	5,509,059 - 5,526,175 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	20	5,509,059 - 5,526,175 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	20	7,567,671 - 7,585,188 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	20	5,150,810 - 5,169,264 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	20	5,151,036 - 5,169,489 (+)	NCBI
Celera	20	6,581,869 - 6,599,528 (+)	NCBI		Celera
Cytogenetic Map	20	p12	NCBI

KIFC1
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	6	33,391,461 - 33,409,896 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	6	33,391,823 - 33,409,896 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	6	33,359,600 - 33,377,673 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	6	33,467,583 - 33,485,625 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Celera	6	34,913,703 - 34,932,095 (+)	NCBI		Celera
Cytogenetic Map	6	p21.32	NCBI
HuRef	6	33,101,381 - 33,119,773 (+)	NCBI		HuRef
CHM1_1	6	33,361,187 - 33,379,567 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	6	33,212,742 - 33,231,258 (+)	NCBI		T2T-CHM13v2.0

Kifc1
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	17	34,094,640 - 34,109,607 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	17	34,094,633 - 34,109,635 (-)	Ensembl		GRCm39 Ensembl
GRCm38	17	33,875,664 - 33,890,633 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	17	33,875,659 - 33,890,661 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	17	34,011,931 - 34,042,544 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	17	27,054,036 - 27,069,524 (+)	NCBI		MGSCv36	mm8
Celera	17	36,628,582 - 36,643,546 (-)	NCBI		Celera
Cytogenetic Map	17	B1	NCBI
cM Map	17	17.98	NCBI

Kifc1
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955437	1,923,506 - 1,940,970 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955437	1,923,136 - 1,941,094 (+)	NCBI	ChiLan1.0	ChiLan1.0

KIFC1
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	5	47,876,580 - 47,894,889 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	6	43,743,866 - 43,761,938 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	6	32,971,033 - 32,989,129 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	6	34,081,586 - 34,100,591 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	6	34,078,842 - 34,100,373 (+)	Ensembl	panpan1.1		panPan2

KIFC1
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	12	2,808,374 - 2,821,203 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	12	2,808,705 - 2,821,217 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	12	2,889,201 - 2,901,948 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	12	3,140,027 - 3,152,781 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	12	3,140,220 - 3,152,876 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	12	2,807,166 - 2,819,907 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	12	2,888,268 - 2,901,012 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	12	2,986,376 - 2,999,127 (+)	NCBI		UU_Cfam_GSD_1.0

Kifc1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404946	38,457,125 - 38,472,793 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936476	25,487,503 - 25,546,359 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936476	25,488,426 - 25,503,135 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

KIFC1
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	7	29,694,778 - 29,713,712 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	7	29,692,775 - 29,713,716 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	7	34,198,547 - 34,212,734 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

KIFC1
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	17	38,656,517 - 38,675,056 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	17	38,656,246 - 38,674,470 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666044	33,240,536 - 33,258,617 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Kifc1
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624754	23,410,007 - 23,413,902 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624754	23,405,951 - 23,421,696 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Kifc1
162 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	48
Count of miRNA genes:	47
Interacting mature miRNAs:	48
Transcripts:	ENSRNOT00000065349
Prediction methods:	Miranda, Rnahybrid
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
2306850	Pia40	Pristane induced arthritis QTL 40		0.0001	joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	20	1527959	5304575	Rat
1354642	Despr15	Despair related QTL 15		0.0027	locomotor behavior trait (VT:0001392)	amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)	20	1	24159021	Rat
4889857	Pur27	Proteinuria QTL 27	12.2	0.001	urine total protein amount (VT:0000032)	urine total protein excretion rate (CMO:0000756)	20	4606607	17617956	Rat
9590109	Sffal8	Serum free fatty acids level QTL 8	5.32	0.01	blood free fatty acid amount (VT:0001553)	plasma free fatty acids level (CMO:0000546)	20	1	29191651	Rat
9590275	Scort15	Serum corticosterone level QTL 15	3.48	0.001	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	20	1	29191651	Rat
7175096	Tcs1	T cell selection QTL 1			T cell selection trait (VT:0004917)	expression	20	4727078	5024580	Rat
6893685	Bw111	Body weight QTL 111	2.7	0.004	body mass (VT:0001259)	body weight (CMO:0000012)	20	1	32578807	Rat
1641915	Colcr9	Colorectal carcinoma resistance QTL 9	2.97	0.0024	intestine integrity trait (VT:0010554)	benign colorectal tumor number (CMO:0001795)	20	1530655	46530655	Rat
2317057	Aia27	Adjuvant induced arthritis QTL 27	2.83		joint integrity trait (VT:0010548)	right rear ankle joint diameter (CMO:0002150)	20	2892597	26381954	Rat
61474	Eae1	Experimental allergic encephalomyelitis QTL 1	3		nervous system integrity trait (VT:0010566)	experimental autoimmune encephalomyelitis severity score (CMO:0001419)	20	4606607	6691706	Rat
7387283	Uae44	Urinary albumin excretion QTL 44		0.1712	urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	20	1	26123605	Rat
7411668	Foco32	Food consumption QTL 32	8	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	20	1	36600972	Rat
2305926	Iddm37	Insulin dependent diabetes mellitus QTL 37	6		blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	20	1527842	46527842	Rat
1600382	Edcs3	Endometrial carcinoma susceptibility QTL3	3.5	0.003	uterus morphology trait (VT:0001120)	percentage of study population developing endometrioid carcinoma during a period of time (CMO:0001759)	20	1	25159026	Rat
1558640	Prcs2	Prostate cancer susceptibility QTL 2	3.3		prostate integrity trait (VT:0010571)	percentage of study population developing ventral prostate tumorous lesions during a period of time (CMO:0000943)	20	4606607	17617956	Rat
1331772	Cdexp2	CD45RC expression in CD8 T cells QTL 2	5.7		CD8-positive T cell quantity (VT:0008077)	blood CD45RC(high) CD8 T cell count to CD45RC(low) CD8 T cell count ratio (CMO:0001990)	20	3621649	10078919	Rat
8694189	Bw153	Body weight QTL 153	3.13	0.001	body mass (VT:0001259)	body weight gain (CMO:0000420)	20	1	29191651	Rat
1300152	Bp195	Blood pressure QTL 195	3.46		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	20	3621649	9243559	Rat
9589155	Insul32	Insulin level QTL 32	6.38	0.001	blood insulin amount (VT:0001560)	plasma insulin level (CMO:0000342)	20	1	29191651	Rat
7411650	Foco23	Food consumption QTL 23	20.7	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	20	1	29191651	Rat
2317851	Alcrsp22	Alcohol response QTL 22	3.2	0.05	response to alcohol trait (VT:0010489)	duration of loss of righting reflex (CMO:0002289)	20	1	27339237	Rat
1598816	Memor12	Memory QTL 12	2.4		exploratory behavior trait (VT:0010471)	average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)	20	2606836	47606836	Rat
61432	Cia1	Collagen induced arthritis QTL 1			joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	20	3621656	14101050	Rat
1641893	Alcrsp7	Alcohol response QTL 7			response to alcohol trait (VT:0010489)	duration of loss of righting reflex (CMO:0002289)	20	1	27339237	Rat
9590252	Scort12	Serum corticosterone level QTL 12	20.46	0.001	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	20	1	36600972	Rat

Markers in Region

UniSTS:236125

Rat Assembly	Chr	Position (strand)	Source	JBrowse
GRCr8	20	5,013,081 - 5,013,345 (+)	Marker Load Pipeline
mRatBN7.2	20	5,011,213 - 5,011,477 (+)	MAPPER	mRatBN7.2
Rnor_6.0	20	5,520,294 - 5,520,557	NCBI	Rnor6.0
Rnor_5.0	20	7,579,303 - 7,579,566	UniSTS	Rnor5.0
RGSC_v3.4	20	5,163,379 - 5,163,642	UniSTS	RGSC3.4
Celera	20	6,593,643 - 6,593,906	UniSTS
Cytogenetic Map	20	p12	UniSTS

UniSTS:463415

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	20	5,009,883 - 5,011,077 (+)	MAPPER	mRatBN7.2
Rnor_6.0	20	5,518,964 - 5,520,157	NCBI	Rnor6.0
Rnor_5.0	20	7,577,973 - 7,579,166	UniSTS	Rnor5.0
RGSC_v3.4	20	5,162,049 - 5,163,242	UniSTS	RGSC3.4
Celera	20	6,592,313 - 6,593,506	UniSTS
Cytogenetic Map	20	p12	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	nervous system	renal system	reproductive system	respiratory system
9	11	49	113	91	90	59	25	59	6	218	97	93	45	60	31

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001005878	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC128962	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AF035951	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC083827	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BX883042	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000020	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000065349 ⟹ ENSRNOP00000061875

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	20	4,999,047 - 5,017,102 (+)	Ensembl
Rnor_6.0 Ensembl	20	5,509,059 - 5,526,175 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000092584

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0 Ensembl	20	5,519,216 - 5,519,923 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000095546 ⟹ ENSRNOP00000087209

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	20	4,999,367 - 5,017,105 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000103176 ⟹ ENSRNOP00000087122

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	20	4,999,060 - 5,017,105 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000114906 ⟹ ENSRNOP00000092623

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	20	4,999,047 - 5,012,147 (+)	Ensembl

RefSeq Acc Id:

NM_001005878 ⟹ NP_001005878

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	20	5,000,929 - 5,018,967 (+)	NCBI
mRatBN7.2	20	4,999,060 - 5,017,107 (+)	NCBI
Rnor_6.0	20	5,509,059 - 5,526,175 (+)	NCBI
Rnor_5.0	20	7,567,671 - 7,585,188 (+)	NCBI
RGSC_v3.4	20	5,150,810 - 5,169,264 (+)	RGD
Celera	20	6,581,869 - 6,599,528 (+)	RGD

Sequence:

show sequence

GGTGGTCTGGCTCCTGGGCCGTCTGGCTCGGGTGTTGCGTGGCGCGAGCCCATGAGAGGACGCG
GGTCTCGGGACACCGGCACCCAGTCTGCTGCCTTTGCATCCCGTCCTGTGCGGACCACCGTGGA
CATGCAGGCACAGAGGGCCCCTTTGATGGAAGTGAAGAGGAACTTGGAGCTGAGCACAACCCTG
GTCAAGTCCTCCTCCCGGCTGCCCCTACCAGGAAGCAGGCTCAAGAGGGGTCCTGACCAGATGG
AGGATGGCCTGGAGCCTGCAAAGAAACGAACACGAGGCATGGGCACAGTGACCAAAGTTGACAC
ATCCCGCCCGAGAGGGCCACCCCTCAGCGCAGTGTCCACTGCAGCTCAGAAAGGCCCTAGGAAG
ACTGGACCTCGAGGGTGCTCTGCTGTCGGTCCAGTGCTGAGGAACCAGAAGCCAGCTCCCGCTG
CTCCTGCCCAGAAGCCAGGCACATCCACTGCTCCTGCGGTGGCAGGAAAGAAACCTGGCAAGCG
TCCTGCCTGGGACTTGAAGGGCCAGTTGTGTGACCTCCATGAAGAGTTGAAACAGTATCGGGAG
AAGACTCAGACACTGGACCGTGAGAACCAGGGGCTCCGAGAGCAACTCAGAGAGGTTCAGGAGC
AGGCCACGACCCTGGGGACAGAGCGGAACACCCTGGAGGAGGAGCTGGCCAGTGTACGCAGGCG
AGCTGAGCAGAGCCAGCAGAAGCTGGAGACTCTGGGTGCCCGCGTCTTGGAGCTGGAGGAATGT
CTGGGTACCAAGGAAAGGCTGGTTCAGGAGCTTCAGACAGAGCGGCTGCAATTGCAGGAGGAAC
GCAGTACACTGAGCACCCAGCTGGAGGAGCGGGAGAGGGAGTTTCAGGCCTCAGAAGCAGCTCT
GTCAAGCAGCCGAGCAGAGGTACTGTGTCTTCGGCAGAAGACTGCAGCCCAGGTGACCTTACTG
GCCGAGCAGGGAGACCGGCTCTATGGGCTAGAGATGGAGCGCCGTCGACTCCACAACCAGCTGC
AGGAACTGAAGGGCAACATCCGGGTCTTCTGCCGGGTGCGCCCTGTCCTTGAGGGGGAGTCCAC
TCCATCTCCTGGCTTCCTTGTATTCCCTCCTGGCCCTGCTGGACCCTCTGACCCCCCAACTCGC
CTTTGCCTCTCTCGGTCTGATGACCGGCGCTCCACCCTGACAAGGGCACCAGCAGCTGCTACCC
GCCATGACTTCTCCTTTGATCGGGTGTTCCCACCAGGAAGCAAGCAGGAGGAGGTGTTTGAGGA
GATCTCCATGCTTGTCCAGTCAGCACTGGATGGCTACCCTGTGTGCATCTTTGCCTATGGACAG
ACAGGCAGCGGCAAGACCTTCACCATGGAGGGCGGGCCTCGGGGAGACCCCCAGTTGGAGGGGC
TGATCCCCCGGGCCATGCGGCATCTGTTCTCTGTGGCCCAGGAGATGAGTGGCCAGGGCTGGAC
TTACAGTTTTGTGGCCAGTTACGTAGAGATCTACAATGAGACCGTCCGAGACCTGCTAGCTACA
GGGACCCGCAAGGGACAAGGGGGCGACTGTGAGATTCGTCGGGCAGGCCCAGGGAGTGAGGAAC
TTACTGTCACCAATGCACGATATGTCCCTGTTTCCTGTGAGAAAGAGGTGGAGGCTCTGCTCCA
TTTGGCCCAGCAGAATCGGGCTGTGGCCCGCACTGCCCAGAATGAGAGATCATCACGCAGCCAC
AGTGTGTTCCAGCTACAGATCTCTGGAGAGCATGCTGCCCGGGGCCTGCAGTGTGGTGCTCCCC
TCAACCTGGTGGACCTGGCTGGGAGTGAGCGGCTTGACCCTGGCTTAACCCTAGGCCCTGGAGA
GCGGGATCGTCTTCGGGAAACACAAGCCATTAACAGCAGTCTGTCTACACTGGGACTGGTCATA
ATGGCCCTGAGCAATAAGGAGTCCCACGTGCCTTACCGAAATAGCAAGCTTACCTACCTGCTGC
AGAACTCTCTGGGTGGCAGTGCCAAGATGCTCATGTTCGTGAACATTTCTCCTCTGGAAGAGAA
TGTCTCCGAGTCTCTGAATTCACTCCGCTTTGCTTCCAAGGTGAACCAGTGCGTGATCGGCACT
GCTCAGGCTAATAAGAAATGAAGATGGATGCAGAGCCTGGCTCCTGTGCAAGCGGGTGTGCGTG
TCTGTTTTGTGTATATGTATAACACGGGGGTGGGGCGGGGCTGAGACATGATTTTATTGGGTGG
ACAACATTATGTACCCAACTATCAAATAAAGAAAATTTGGTGTAGGTTAAAAAAAAAAAAAAAA
AAAAAAAAAAAA

hide sequence

Protein Sequences


Protein RefSeqs	NP_001005878	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAB88699	(Get FASTA)	NCBI Sequence Viewer
	AAH83827	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000087122
GenBank Protein	Q5XI63	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

NP_001005878 ⟸ NM_001005878

- UniProtKB:

O54719 (UniProtKB/Swiss-Prot), Q5XI63 (UniProtKB/Swiss-Prot), A0A8L2QUA0 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MRGRGSRDTGTQSAAFASRPVRTTVDMQAQRAPLMEVKRNLELSTTLVKSSSRLPLPGSRLKRG
PDQMEDGLEPAKKRTRGMGTVTKVDTSRPRGPPLSAVSTAAQKGPRKTGPRGCSAVGPVLRNQK
PAPAAPAQKPGTSTAPAVAGKKPGKRPAWDLKGQLCDLHEELKQYREKTQTLDRENQGLREQLR
EVQEQATTLGTERNTLEEELASVRRRAEQSQQKLETLGARVLELEECLGTKERLVQELQTERLQ
LQEERSTLSTQLEEREREFQASEAALSSSRAEVLCLRQKTAAQVTLLAEQGDRLYGLEMERRRL
HNQLQELKGNIRVFCRVRPVLEGESTPSPGFLVFPPGPAGPSDPPTRLCLSRSDDRRSTLTRAP
AAATRHDFSFDRVFPPGSKQEEVFEEISMLVQSALDGYPVCIFAYGQTGSGKTFTMEGGPRGDP
QLEGLIPRAMRHLFSVAQEMSGQGWTYSFVASYVEIYNETVRDLLATGTRKGQGGDCEIRRAGP
GSEELTVTNARYVPVSCEKEVEALLHLAQQNRAVARTAQNERSSRSHSVFQLQISGEHAARGLQ
CGAPLNLVDLAGSERLDPGLTLGPGERDRLRETQAINSSLSTLGLVIMALSNKESHVPYRNSKL
TYLLQNSLGGSAKMLMFVNISPLEENVSESLNSLRFASKVNQCVIGTAQANKK

hide sequence

Ensembl Acc Id:

ENSRNOP00000061875 ⟸ ENSRNOT00000065349

Ensembl Acc Id:

ENSRNOP00000087122 ⟸ ENSRNOT00000103176

Ensembl Acc Id:

ENSRNOP00000087209 ⟸ ENSRNOT00000095546

Ensembl Acc Id:

ENSRNOP00000092623 ⟸ ENSRNOT00000114906

Protein Domains

Kinesin motor

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q5XI63-F1-model_v2	AlphaFold	Q5XI63	1-693	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13701417

Promoter ID:

EPDNEW_R11941

Type:

initiation region

Name:

Kifc1_1

Description:

kinesin family member C1

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	20	5,509,066 - 5,509,126	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1359118	AgrOrtholog
BioCyc Gene	G2FUF-4506	BioCyc
Ensembl Genes	ENSRNOG00000000479	Ensembl, ENTREZGENE
Ensembl Transcript	ENSRNOT00000103176	ENTREZGENE
Gene3D-CATH	1.10.287.1490	UniProtKB/Swiss-Prot
	3.40.850.10	UniProtKB/Swiss-Prot
IMAGE_CLONE	IMAGE:7112250	IMAGE-MGC_LOAD
InterPro	Kinesin-like_fam	UniProtKB/Swiss-Prot
	Kinesin_motor_CS	UniProtKB/Swiss-Prot
	Kinesin_motor_dom	UniProtKB/Swiss-Prot
	Kinesin_motor_dom_sf	UniProtKB/Swiss-Prot
	P-loop_NTPase	UniProtKB/Swiss-Prot
KEGG Report	rno:294286	UniProtKB/Swiss-Prot
MGC_CLONE	MGC:94918	IMAGE-MGC_LOAD
NCBI Gene	294286	ENTREZGENE
PANTHER	KINESIN-LIKE PROTEIN KLP-3	UniProtKB/Swiss-Prot
	PROTEIN CLARET SEGREGATIONAL	UniProtKB/Swiss-Prot
Pfam	Kinesin	UniProtKB/Swiss-Prot
PhenoGen	Kifc1	PhenoGen
PRINTS	KINESINHEAVY	UniProtKB/Swiss-Prot
PROSITE	KINESIN_MOTOR_1	UniProtKB/Swiss-Prot
	KINESIN_MOTOR_2	UniProtKB/Swiss-Prot
RatGTEx	ENSRNOG00000000479	RatGTEx
SMART	KISc	UniProtKB/Swiss-Prot
Superfamily-SCOP	SSF52540	UniProtKB/Swiss-Prot
	Tropomyosin	UniProtKB/Swiss-Prot
UniProt	A0A8I6AVX0_RAT	UniProtKB/TrEMBL
	A0A8I6GEU0_RAT	UniProtKB/TrEMBL
	A0A8I6GEW9_RAT	UniProtKB/TrEMBL
	A0A8L2QUA0	ENTREZGENE, UniProtKB/TrEMBL
	KIFC1_RAT	UniProtKB/Swiss-Prot
	O54719	ENTREZGENE
	Q5XI63	ENTREZGENE
UniProt Secondary	O54719	UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2006-03-30	Kifc1	kinesin family member C1			Symbol and Name status set to approved	1299863	APPROVED
2005-07-29	Kifc1	kinesin family member C1			Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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