Ppt2 (palmitoyl-protein thioesterase 2) - Rat Genome Database

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Gene: Ppt2 (palmitoyl-protein thioesterase 2) Rattus norvegicus
Analyze
Symbol: Ppt2
Name: palmitoyl-protein thioesterase 2
RGD ID: 620375
Description: Predicted to enable palmitoyl hydrolase activity and thiolester hydrolase activity. Predicted to be involved in macromolecule depalmitoylation. Predicted to be active in lysosome. Orthologous to human PPT2 (palmitoyl-protein thioesterase 2); PARTICIPATES IN fatty acid elongation pathway; INTERACTS WITH (+)-schisandrin B; 2,3,7,8-tetrachlorodibenzodioxine; 2,6-dinitrotoluene.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: lysosomal thioesterase PPT2; PPT-2
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8204,117,088 - 4,137,382 (+)NCBIGRCr8
mRatBN7.2204,112,520 - 4,132,774 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl204,122,463 - 4,132,774 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx204,830,255 - 4,839,271 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0204,192,007 - 4,201,023 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0204,722,932 - 4,731,947 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0204,381,455 - 4,401,638 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl204,381,455 - 4,401,610 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0206,460,811 - 6,481,339 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4204,225,630 - 4,234,653 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1204,225,924 - 4,234,876 (+)NCBI
Celera203,897,484 - 3,906,509 (-)NCBICelera
Cytogenetic Map20p12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
lysosome  (IBA)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Characterization of a human MHC class III region gene product with S-thioesterase activity. Aguado B and Campbell RD, Biochem J 1999 Aug 1;341 ( Pt 3):679-89.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
4. Disruption of PPT1 or PPT2 causes neuronal ceroid lipofuscinosis in knockout mice. Gupta P, etal., Proc Natl Acad Sci U S A 2001 Nov 20;98(24):13566-71.
5. Disruption of PPT2 in mice causes an unusual lysosomal storage disorder with neurovisceral features. Gupta P, etal., Proc Natl Acad Sci U S A 2003 Oct 14;100(21):12325-30.
6. The genomic sequence and comparative analysis of the rat major histocompatibility complex. Hurt P, etal., Genome Res 2004 Apr;14(4):631-9.
7. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
8. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
9. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
10. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
11. Molecular cloning and expression of palmitoyl-protein thioesterase 2 (PPT2), a homolog of lysosomal palmitoyl-protein thioesterase with a distinct substrate specificity. Soyombo AA and Hofmann SL, J Biol Chem 1997 Oct 24;272(43):27456-63.
12. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
Additional References at PubMed
PMID:15489334   PMID:23376485   PMID:23533145  


Genomics

Comparative Map Data
Ppt2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8204,117,088 - 4,137,382 (+)NCBIGRCr8
mRatBN7.2204,112,520 - 4,132,774 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl204,122,463 - 4,132,774 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx204,830,255 - 4,839,271 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0204,192,007 - 4,201,023 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0204,722,932 - 4,731,947 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0204,381,455 - 4,401,638 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl204,381,455 - 4,401,610 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0206,460,811 - 6,481,339 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4204,225,630 - 4,234,653 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1204,225,924 - 4,234,876 (+)NCBI
Celera203,897,484 - 3,906,509 (-)NCBICelera
Cytogenetic Map20p12NCBI
PPT2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38632,153,528 - 32,163,675 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl632,153,441 - 32,163,678 (+)EnsemblGRCh38hg38GRCh38
GRCh37632,121,305 - 32,131,452 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36632,229,279 - 32,239,430 (+)NCBINCBI36Build 36hg18NCBI36
Build 34632,229,599 - 32,244,032NCBI
Celera633,688,341 - 33,698,499 (+)NCBICelera
Cytogenetic Map6p21.32NCBI
HuRef631,875,218 - 31,885,450 (+)NCBIHuRef
CHM1_1632,123,732 - 32,133,942 (+)NCBICHM1_1
T2T-CHM13v2.0632,006,716 - 32,016,865 (+)NCBIT2T-CHM13v2.0
Ppt2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391734,835,636 - 34,856,993 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1734,835,636 - 34,847,484 (-)EnsemblGRCm39 Ensembl
GRCm381734,616,662 - 34,638,022 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1734,616,662 - 34,628,510 (-)EnsemblGRCm38mm10GRCm38
MGSCv371734,753,607 - 34,764,042 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361734,224,718 - 34,235,161 (-)NCBIMGSCv36mm8
Celera1737,711,835 - 37,722,272 (-)NCBICelera
Cytogenetic Map17B1NCBI
cM Map1718.19NCBI
Ppt2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955437619,085 - 630,965 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955437609,901 - 630,004 (+)NCBIChiLan1.0ChiLan1.0
PPT2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2546,615,759 - 46,628,033 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1642,577,249 - 42,588,204 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0631,800,096 - 31,811,047 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1632,680,175 - 32,692,199 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl632,680,175 - 32,695,549 (+)Ensemblpanpan1.1panPan2
PPT2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1121,549,148 - 1,557,924 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl121,550,719 - 1,557,939 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha121,682,811 - 1,691,619 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0121,687,333 - 1,696,122 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl121,684,169 - 1,696,123 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1121,550,352 - 1,559,159 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0121,615,976 - 1,624,774 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0121,682,277 - 1,691,086 (+)NCBIUU_Cfam_GSD_1.0
LOC101974337
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494636,113,543 - 36,126,491 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049367271,438,593 - 1,446,956 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0 EnsemblNW_0049367271,435,166 - 1,437,009 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049367271,438,593 - 1,447,728 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PPT2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl724,188,030 - 24,200,704 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1724,188,335 - 24,200,707 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2728,009,030 - 28,021,533 (+)NCBISscrofa10.2Sscrofa10.2susScr3
PPT2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11739,867,403 - 39,877,903 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366604432,053,713 - 32,064,313 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ppt2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475424,155,314 - 24,169,434 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462475424,156,063 - 24,163,518 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Ppt2
132 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:174
Count of miRNA genes:98
Interacting mature miRNAs:109
Transcripts:ENSRNOT00000000497
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
61472Aia1Adjuvant induced arthritis QTL 1180.001joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)2026463954597031Rat
2306850Pia40Pristane induced arthritis QTL 400.0001joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)2015279595304575Rat
1641915Colcr9Colorectal carcinoma resistance QTL 92.970.0024intestine integrity trait (VT:0010554)benign colorectal tumor number (CMO:0001795)20153065546530655Rat
2317057Aia27Adjuvant induced arthritis QTL 272.83joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)20289259726381954Rat
7411668Foco32Food consumption QTL 3280.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)20136600972Rat
2305926Iddm37Insulin dependent diabetes mellitus QTL 376blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)20152784246527842Rat
1354642Despr15Despair related QTL 150.0027locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)20124159021Rat
1600382Edcs3Endometrial carcinoma susceptibility QTL33.50.003uterus morphology trait (VT:0001120)percentage of study population developing endometrioid carcinoma during a period of time (CMO:0001759)20125159026Rat
61448Ciaa1CIA Autoantibody QTL 1300.001blood autoantibody amount (VT:0003725)calculated serum anti-rat type 2 collagen autoantibody titer (CMO:0001281)2026463954597031Rat
1331772Cdexp2CD45RC expression in CD8 T cells QTL 25.7CD8-positive T cell quantity (VT:0008077)blood CD45RC(high) CD8 T cell count to CD45RC(low) CD8 T cell count ratio (CMO:0001990)20362164910078919Rat
8694189Bw153Body weight QTL 1533.130.001body mass (VT:0001259)body weight gain (CMO:0000420)20129191651Rat
1300152Bp195Blood pressure QTL 1953.46arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2036216499243559Rat
9590109Sffal8Serum free fatty acids level QTL 85.320.01blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)20129191651Rat
9590275Scort15Serum corticosterone level QTL 153.480.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)20129191651Rat
9589155Insul32Insulin level QTL 326.380.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)20129191651Rat
7411650Foco23Food consumption QTL 2320.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)20129191651Rat
2317851Alcrsp22Alcohol response QTL 223.20.05response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)20127339237Rat
1598816Memor12Memory QTL 122.4exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)20260683647606836Rat
61432Cia1Collagen induced arthritis QTL 1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)20362165614101050Rat
1641893Alcrsp7Alcohol response QTL 7response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)20127339237Rat
6893685Bw111Body weight QTL 1112.70.004body mass (VT:0001259)body weight (CMO:0000012)20132578807Rat
9590252Scort12Serum corticosterone level QTL 1220.460.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)20136600972Rat
737973Pia21Pristane induced arthritis QTL 214.8joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)2036216564606812Rat

Markers in Region
D20Yum62  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2204,127,533 - 4,127,683 (-)MAPPERmRatBN7.2
Rnor_6.0204,386,543 - 4,386,692NCBIRnor6.0
Rnor_5.0206,465,899 - 6,466,048UniSTSRnor5.0
RGSC_v3.4204,229,412 - 4,229,561UniSTSRGSC3.4
Celera203,902,577 - 3,902,730UniSTS
Cytogenetic Map20p12UniSTS
BF405332  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2204,124,633 - 4,125,169 (-)MAPPERmRatBN7.2
Rnor_6.0204,389,057 - 4,389,592NCBIRnor6.0
Rnor_5.0206,468,413 - 6,468,948UniSTSRnor5.0
RGSC_v3.4204,226,512 - 4,227,047UniSTSRGSC3.4
Celera203,905,092 - 3,905,627UniSTS
RH 3.4 Map2055.93UniSTS
Cytogenetic Map20p12UniSTS
RH140482  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2204,132,361 - 4,132,493 (-)MAPPERmRatBN7.2
Rnor_6.0204,381,736 - 4,381,867NCBIRnor6.0
Rnor_5.0206,461,092 - 6,461,223UniSTSRnor5.0
RGSC_v3.4204,234,241 - 4,234,372UniSTSRGSC3.4
Celera203,897,765 - 3,897,896UniSTS
Cytogenetic Map20p12UniSTS
RH124332  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2204,132,455 - 4,132,618 (-)MAPPERmRatBN7.2
Rnor_6.0204,381,611 - 4,381,773NCBIRnor6.0
Rnor_5.0206,460,967 - 6,461,129UniSTSRnor5.0
RGSC_v3.4204,234,335 - 4,234,497UniSTSRGSC3.4
Celera203,897,640 - 3,897,802UniSTS
Cytogenetic Map20p12UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 2 35 37 23 18 23 3 66 31 33 9
Low 1 8 20 18 1 18 8 8 8 4 8 2 8
Below cutoff

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_019367 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006256017 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006256019 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006256020 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006256022 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006256023 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008772762 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017601766 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017601767 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039099041 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039099045 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AF061971 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF067790 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC062023 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BX883044 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CB736242 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH474121 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ234132 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000020 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

RefSeq Acc Id: ENSRNOT00000000497   ⟹   ENSRNOP00000000497
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl204,123,739 - 4,132,770 (+)Ensembl
Rnor_6.0 Ensembl204,381,455 - 4,390,436 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000077655   ⟹   ENSRNOP00000072227
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl204,388,909 - 4,390,579 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000080476   ⟹   ENSRNOP00000074687
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl204,123,197 - 4,132,770 (+)Ensembl
Rnor_6.0 Ensembl204,389,466 - 4,392,343 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000083489   ⟹   ENSRNOP00000074011
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl204,122,463 - 4,132,774 (+)Ensembl
Rnor_6.0 Ensembl204,389,092 - 4,391,473 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000086544
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl204,388,657 - 4,389,523 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000087055
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl204,388,635 - 4,389,911 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000090518   ⟹   ENSRNOP00000074652
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl204,123,197 - 4,132,120 (+)Ensembl
Rnor_6.0 Ensembl204,388,910 - 4,391,402 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000091468   ⟹   ENSRNOP00000074361
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl204,122,985 - 4,132,770 (+)Ensembl
Rnor_6.0 Ensembl204,381,455 - 4,401,610 (-)Ensembl
RefSeq Acc Id: NM_019367   ⟹   NP_062240
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8204,128,360 - 4,137,382 (+)NCBI
mRatBN7.2204,123,752 - 4,132,774 (+)NCBI
Rnor_6.0204,381,455 - 4,390,474 (-)NCBI
Rnor_5.0206,460,811 - 6,481,339 (-)NCBI
RGSC_v3.4204,225,630 - 4,234,653 (+)RGD
Celera203,897,484 - 3,906,509 (-)RGD
Sequence:
RefSeq Acc Id: XM_006256017   ⟹   XP_006256079
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8204,117,088 - 4,137,382 (+)NCBI
mRatBN7.2204,112,520 - 4,132,774 (+)NCBI
Rnor_6.0204,381,455 - 4,401,638 (-)NCBI
Rnor_5.0206,460,811 - 6,481,339 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006256019   ⟹   XP_006256081
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8204,127,767 - 4,137,382 (+)NCBI
mRatBN7.2204,123,159 - 4,132,774 (+)NCBI
Rnor_6.0204,381,455 - 4,391,946 (-)NCBI
Rnor_5.0206,460,811 - 6,481,339 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006256020   ⟹   XP_006256082
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8204,127,028 - 4,137,382 (+)NCBI
mRatBN7.2204,122,524 - 4,132,774 (+)NCBI
Rnor_6.0204,381,455 - 4,391,946 (-)NCBI
Rnor_5.0206,460,811 - 6,481,339 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006256022   ⟹   XP_006256084
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8204,127,028 - 4,137,382 (+)NCBI
mRatBN7.2204,122,524 - 4,132,774 (+)NCBI
Rnor_6.0204,381,455 - 4,391,945 (-)NCBI
Rnor_5.0206,460,811 - 6,481,339 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006256023   ⟹   XP_006256085
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8204,126,472 - 4,137,382 (+)NCBI
mRatBN7.2204,121,864 - 4,132,774 (+)NCBI
Rnor_6.0204,381,455 - 4,392,550 (-)NCBI
Rnor_5.0206,460,811 - 6,481,339 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008772762   ⟹   XP_008770984
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8204,128,522 - 4,137,382 (+)NCBI
mRatBN7.2204,123,909 - 4,132,774 (+)NCBI
Rnor_6.0204,381,455 - 4,391,946 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039099041   ⟹   XP_038954969
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8204,117,181 - 4,137,382 (+)NCBI
mRatBN7.2204,112,566 - 4,132,774 (+)NCBI
RefSeq Acc Id: XM_039099045   ⟹   XP_038954973
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8204,128,876 - 4,137,382 (+)NCBI
mRatBN7.2204,121,864 - 4,132,774 (+)NCBI
Protein Sequences
Protein RefSeqs NP_062240 (Get FASTA)   NCBI Sequence Viewer  
  XP_006256079 (Get FASTA)   NCBI Sequence Viewer  
  XP_006256081 (Get FASTA)   NCBI Sequence Viewer  
  XP_006256082 (Get FASTA)   NCBI Sequence Viewer  
  XP_006256084 (Get FASTA)   NCBI Sequence Viewer  
  XP_006256085 (Get FASTA)   NCBI Sequence Viewer  
  XP_008770984 (Get FASTA)   NCBI Sequence Viewer  
  XP_038954969 (Get FASTA)   NCBI Sequence Viewer  
  XP_038954973 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAC16003 (Get FASTA)   NCBI Sequence Viewer  
  AAC19366 (Get FASTA)   NCBI Sequence Viewer  
  AAH62023 (Get FASTA)   NCBI Sequence Viewer  
  CAE83963 (Get FASTA)   NCBI Sequence Viewer  
  EDL83408 (Get FASTA)   NCBI Sequence Viewer  
  EDL83409 (Get FASTA)   NCBI Sequence Viewer  
  EDL83410 (Get FASTA)   NCBI Sequence Viewer  
  EDL83411 (Get FASTA)   NCBI Sequence Viewer  
  EDL83412 (Get FASTA)   NCBI Sequence Viewer  
  EDL83413 (Get FASTA)   NCBI Sequence Viewer  
  EDL83414 (Get FASTA)   NCBI Sequence Viewer  
  EDL83415 (Get FASTA)   NCBI Sequence Viewer  
  EDL83416 (Get FASTA)   NCBI Sequence Viewer  
  EDL83417 (Get FASTA)   NCBI Sequence Viewer  
  EDL83418 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000000497.5
  ENSRNOP00000074011.2
  ENSRNOP00000074361.2
  ENSRNOP00000074652.2
  ENSRNOP00000074687
  ENSRNOP00000074687.2
  ENSRNOP00055008514
  ENSRNOP00060009174
  ENSRNOP00065039317
GenBank Protein O70489 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_062240   ⟸   NM_019367
- Peptide Label: precursor
- UniProtKB: O88500 (UniProtKB/Swiss-Prot),   O70489 (UniProtKB/Swiss-Prot),   A6KTI0 (UniProtKB/TrEMBL),   A0A8L2R8R8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006256079   ⟸   XM_006256017
- Peptide Label: isoform X1
- UniProtKB: O88500 (UniProtKB/Swiss-Prot),   O70489 (UniProtKB/Swiss-Prot),   A6KTI0 (UniProtKB/TrEMBL),   A0A8L2R8R8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006256085   ⟸   XM_006256023
- Peptide Label: isoform X1
- UniProtKB: O88500 (UniProtKB/Swiss-Prot),   O70489 (UniProtKB/Swiss-Prot),   A6KTI0 (UniProtKB/TrEMBL),   A0A8L2R8R8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006256084   ⟸   XM_006256022
- Peptide Label: isoform X1
- UniProtKB: O88500 (UniProtKB/Swiss-Prot),   O70489 (UniProtKB/Swiss-Prot),   A6KTI0 (UniProtKB/TrEMBL),   A0A8L2R8R8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006256082   ⟸   XM_006256020
- Peptide Label: isoform X1
- UniProtKB: O88500 (UniProtKB/Swiss-Prot),   O70489 (UniProtKB/Swiss-Prot),   A6KTI0 (UniProtKB/TrEMBL),   A0A8L2R8R8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006256081   ⟸   XM_006256019
- Peptide Label: isoform X1
- UniProtKB: O88500 (UniProtKB/Swiss-Prot),   O70489 (UniProtKB/Swiss-Prot),   A6KTI0 (UniProtKB/TrEMBL),   A0A8L2R8R8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008770984   ⟸   XM_008772762
- Peptide Label: isoform X1
- UniProtKB: O88500 (UniProtKB/Swiss-Prot),   O70489 (UniProtKB/Swiss-Prot),   A6KTI0 (UniProtKB/TrEMBL),   A0A8L2R8R8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000074687   ⟸   ENSRNOT00000080476
RefSeq Acc Id: ENSRNOP00000000497   ⟸   ENSRNOT00000000497
RefSeq Acc Id: ENSRNOP00000074652   ⟸   ENSRNOT00000090518
RefSeq Acc Id: ENSRNOP00000072227   ⟸   ENSRNOT00000077655
RefSeq Acc Id: ENSRNOP00000074361   ⟸   ENSRNOT00000091468
RefSeq Acc Id: ENSRNOP00000074011   ⟸   ENSRNOT00000083489
RefSeq Acc Id: XP_038954969   ⟸   XM_039099041
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038954973   ⟸   XM_039099045
- Peptide Label: isoform X3
Protein Domains
AB hydrolase-1

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-O70489-F1-model_v2 AlphaFold O70489 1-302 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13701345
Promoter ID:EPDNEW_R11869
Type:multiple initiation site
Name:Ppt2_1
Description:palmitoyl-protein thioesterase 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R11870  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0204,390,439 - 4,390,499EPDNEW
RGD ID:13701352
Promoter ID:EPDNEW_R11870
Type:single initiation site
Name:Ppt2_2
Description:palmitoyl-protein thioesterase 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R11869  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0204,391,412 - 4,391,472EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620375 AgrOrtholog
BioCyc Gene G2FUF-4589 BioCyc
Ensembl Genes ENSRNOG00000000435 Ensembl, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSRNOG00055006698 UniProtKB/Swiss-Prot
  ENSRNOG00060007391 UniProtKB/Swiss-Prot
  ENSRNOG00065027782 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000000497.8 UniProtKB/TrEMBL
  ENSRNOT00000080476 UniProtKB/TrEMBL
  ENSRNOT00000080476.2 UniProtKB/Swiss-Prot
  ENSRNOT00000083489.2 UniProtKB/TrEMBL
  ENSRNOT00000090518.2 UniProtKB/TrEMBL
  ENSRNOT00000091468.2 UniProtKB/TrEMBL
  ENSRNOT00055010930 UniProtKB/Swiss-Prot
  ENSRNOT00060012158 UniProtKB/Swiss-Prot
  ENSRNOT00065047909 UniProtKB/Swiss-Prot
Gene3D-CATH 3.40.50.1820 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:5623515 IMAGE-MGC_LOAD
InterPro AB_hydrolase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  AB_hydrolase_1 UniProtKB/TrEMBL
  Palm_thioest UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:54398 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE MGC:72477 IMAGE-MGC_LOAD
NCBI Gene 54398 ENTREZGENE
PANTHER PALMITOYL-PROTEIN THIOESTERASE/DOLICHYLDIPHOSPHATASE 1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR11247:SF27 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Abhydrolase_1 UniProtKB/TrEMBL
  Palm_thioest UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Ppt2 PhenoGen
PRINTS PPTHIESTRASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000000435 RatGTEx
  ENSRNOG00055006698 RatGTEx
  ENSRNOG00060007391 RatGTEx
  ENSRNOG00065027782 RatGTEx
Superfamily-SCOP SSF53474 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0G2K706_RAT UniProtKB/TrEMBL
  A0A0G2K8P6_RAT UniProtKB/TrEMBL
  A0A1B0GX57_RAT UniProtKB/TrEMBL
  A0A8L2Q099_RAT UniProtKB/TrEMBL
  A0A8L2R8R8 ENTREZGENE, UniProtKB/TrEMBL
  A6KTH8_RAT UniProtKB/TrEMBL
  A6KTH9_RAT UniProtKB/TrEMBL
  A6KTI0 ENTREZGENE, UniProtKB/TrEMBL
  A6KTI4_RAT UniProtKB/TrEMBL
  A6KTI8_RAT UniProtKB/TrEMBL
  O70489 ENTREZGENE
  O88500 ENTREZGENE
  PPT2_RAT UniProtKB/Swiss-Prot
UniProt Secondary O88500 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2004-02-26 Ppt2  palmitoyl-protein thioesterase 2      Symbol and Name status set to approved 625702 APPROVED
2002-08-07 Ppt2  palmitoyl-protein thioesterase 2      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_mapping found in the major histocompatibility RT1 complex 1300431
gene_mutations_overexpression disruption of the mouse homolog causes an atypical lysosomal storage disorder with abnormal viseral findings 731238