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Gene: Ostm1 (osteoclastogenesis associated transmembrane protein 1) Rattus norvegicus

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Symbol:

Ostm1

Name:

osteoclastogenesis associated transmembrane protein 1

RGD ID:

1564976

Description:

Predicted to be involved in osteoclast differentiation and transepithelial chloride transport. Predicted to be located in lysosomal membrane. Predicted to be part of chloride channel complex. Predicted to be active in cytosol. Human ortholog(s) of this gene implicated in autosomal recessive osteopetrosis 5. Orthologous to human OSTM1 (osteoclastogenesis associated transmembrane protein 1); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; acetamide; bisphenol A.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

GAIP interacting protein N terminus; Gipn; LOC499474; MGC116111; osteopetrosis associated transmembrane protein 1; osteopetrosis associated transmembrane protein 1-like; osteopetrosis-associated transmembrane protein 1; similar to osteopetrosis associated transmembrane protein 1

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	20	47,653,696 - 47,769,248 (+)	NCBI		GRCr8
mRatBN7.2	20	46,071,657 - 46,187,049 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	20	46,153,075 - 46,187,023 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	20	47,870,532 - 47,904,458 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	20	47,520,687 - 47,554,613 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	20	48,212,885 - 48,246,518 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	20	47,394,979 - 47,430,304 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	20	47,395,014 - 47,430,284 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	20	49,062,739 - 49,092,292 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
Celera	20	53,793,629 - 53,820,512 (-)	NCBI		Celera
Cytogenetic Map	20	q13	NCBI

JBrowse:

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Model

Annotation Click to see Annotation Detail View

Imported Disease Annotations - ClinVar

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Ostm1	Rat	autosomal recessive osteopetrosis 5		ISO	RGD:1345018	8554872	ClinVar Annotator: match by term: Autosomal recessive osteopetrosis 5 \| ClinVar Annotator: match by term: more ...	ClinVar	PMID:12627228\|PMID:15108279\|PMID:16813530\|PMID:25741868\|PMID:28492532\|PMID:28612835\|PMID:34753502
Ostm1	Rat	Charcot-Marie-Tooth disease type 4		ISO	RGD:1345018	8554872	ClinVar Annotator: match by term: Charcot-Marie-Tooth disease type 4	ClinVar	PMID:23623387\|PMID:28492532
Ostm1	Rat	genetic disease		ISO	RGD:1345018	8554872	ClinVar Annotator: match by term: Inborn genetic diseases	ClinVar	PMID:28492532
Ostm1	Rat	osteopetrosis		ISO	RGD:1345018	8554872	ClinVar Annotator: match by term: Osteopetrosis	ClinVar	PMID:25741868

Imported Disease Annotations - CTD

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Ostm1	Rat	autosomal recessive osteopetrosis 5		ISO	RGD:1345018	11554173	CTD Direct Evidence: marker/mechanism	CTD

Imported Disease Annotations - MGI

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Ostm1	Rat	autosomal recessive osteopetrosis 5		ISS	RGD:1621630	13592920	OMIM:259720	MouseDO

Imported Disease Annotations - OMIM

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Ostm1	Rat	autosomal recessive osteopetrosis 5		ISO	RGD:1345018	7240710		OMIM

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Ostm1	Rat	(-)-epigallocatechin 3-gallate	increases expression	ISO	RGD:1345018	6480464	epigallocatechin gallate results in increased expression of OSTM1 mRNA	CTD	PMID:35701726
Ostm1	Rat	1,2-dichloroethane	decreases expression	ISO	RGD:1621630	6480464	ethylene dichloride results in decreased expression of OSTM1 mRNA	CTD	PMID:28960355
Ostm1	Rat	1,2-dimethylhydrazine	decreases expression	ISO	RGD:1621630	6480464	1,2-Dimethylhydrazine results in decreased expression of OSTM1 mRNA	CTD	PMID:22206623
Ostm1	Rat	2,3,7,8-tetrachlorodibenzodioxine	affects expression	EXP		6480464	Tetrachlorodibenzodioxin affects the expression of OSTM1 mRNA	CTD	PMID:22298810
Ostm1	Rat	2,3,7,8-tetrachlorodibenzodioxine	affects expression	ISO	RGD:1621630	6480464	Tetrachlorodibenzodioxin affects the expression of OSTM1 mRNA	CTD	PMID:21570461
Ostm1	Rat	3,4-dichloroaniline	increases expression	ISO	RGD:1345018	6480464	3,4-dichloroaniline results in increased expression of OSTM1 mRNA	CTD	PMID:24172598
Ostm1	Rat	acetamide	decreases expression	EXP		6480464	acetamide results in decreased expression of OSTM1 mRNA	CTD	PMID:31881176
Ostm1	Rat	aflatoxin B1	affects expression	ISO	RGD:1345018	6480464	Aflatoxin B1 affects the expression of OSTM1 protein	CTD	PMID:20106945
Ostm1	Rat	aflatoxin B1	increases expression	ISO	RGD:1345018	6480464	Aflatoxin B1 results in increased expression of OSTM1 mRNA	CTD	PMID:27153756
Ostm1	Rat	Aflatoxin B2 alpha	decreases methylation	ISO	RGD:1345018	6480464	aflatoxin B2 results in decreased methylation of OSTM1 intron	CTD	PMID:30157460
Ostm1	Rat	all-trans-retinoic acid	increases expression	ISO	RGD:1345018	6480464	Tretinoin results in increased expression of OSTM1 mRNA	CTD	PMID:23724009\|PMID:33167477
Ostm1	Rat	anthra[1,9-cd]pyrazol-6(2H)-one	multiple interactions	ISO	RGD:1621630	6480464	[crocin co-treated with pyrazolanthrone co-treated with TNFSF11 protein] results in decreased expression of OSTM1 mRNA; more ...	CTD	PMID:30580027
Ostm1	Rat	antirheumatic drug	decreases expression	ISO	RGD:1345018	6480464	Antirheumatic Agents results in decreased expression of OSTM1 mRNA	CTD	PMID:24449571
Ostm1	Rat	apilimod	affects response to substance	ISO	RGD:1345018	6480464	OSTM1 protein affects the susceptibility to apilimod	CTD	PMID:28104689\|PMID:28350209
Ostm1	Rat	aristolochic acid A	increases expression	ISO	RGD:1345018	6480464	aristolochic acid I results in increased expression of OSTM1 mRNA	CTD	PMID:33212167
Ostm1	Rat	arsane	multiple interactions	ISO	RGD:1345018	6480464	[sodium arsenite results in increased abundance of Arsenic] which results in decreased expression of OSTM1 more ...	CTD	PMID:39836092
Ostm1	Rat	arsenic atom	multiple interactions	ISO	RGD:1345018	6480464	[sodium arsenite results in increased abundance of Arsenic] which results in decreased expression of OSTM1 more ...	CTD	PMID:39836092
Ostm1	Rat	avobenzone	increases expression	ISO	RGD:1345018	6480464	avobenzone results in increased expression of OSTM1 mRNA	CTD	PMID:31016361
Ostm1	Rat	benzo[a]pyrene	increases expression	ISO	RGD:1621630	6480464	Benzo(a)pyrene results in increased expression of OSTM1 mRNA	CTD	PMID:22228805
Ostm1	Rat	benzo[a]pyrene diol epoxide I	increases expression	ISO	RGD:1345018	6480464	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased expression of OSTM1 mRNA	CTD	PMID:20382639
Ostm1	Rat	Bergenin	multiple interactions	ISO	RGD:1621630	6480464	bergenin inhibits the reaction [[TNFSF11 protein co-treated with Pyruvaldehyde] results in increased expression of OSTM1 more ...	CTD	PMID:31369791
Ostm1	Rat	beta-lapachone	increases expression	ISO	RGD:1345018	6480464	beta-lapachone results in increased expression of OSTM1 mRNA	CTD	PMID:38218311
Ostm1	Rat	bis(2-ethylhexyl) phthalate	decreases expression	ISO	RGD:1621630	6480464	Diethylhexyl Phthalate results in decreased expression of OSTM1 mRNA	CTD	PMID:34319233
Ostm1	Rat	bisphenol A	increases expression	ISO	RGD:1621630	6480464	bisphenol A results in increased expression of OSTM1 mRNA	CTD	PMID:26063408
Ostm1	Rat	bisphenol A	decreases methylation	ISO	RGD:1345018	6480464	bisphenol A results in decreased methylation of OSTM1 gene	CTD	PMID:31601247
Ostm1	Rat	bisphenol A	multiple interactions	ISO	RGD:1345018	6480464	[bisphenol A co-treated with Fulvestrant] results in increased methylation of OSTM1 gene; [ginger extract results more ...	CTD	PMID:31601247\|PMID:33376534
Ostm1	Rat	bisphenol A	increases expression	ISO	RGD:1345018	6480464	bisphenol A results in increased expression of OSTM1 protein	CTD	PMID:33376534
Ostm1	Rat	bisphenol A	affects expression	EXP		6480464	bisphenol A affects the expression of OSTM1 mRNA	CTD	PMID:25181051
Ostm1	Rat	Bisphenol B	increases expression	ISO	RGD:1345018	6480464	bisphenol B results in increased expression of OSTM1 protein	CTD	PMID:34186270
Ostm1	Rat	bisphenol F	increases expression	ISO	RGD:1621630	6480464	bisphenol F results in increased expression of OSTM1 mRNA	CTD	PMID:38685157
Ostm1	Rat	bisphenol F	increases expression	ISO	RGD:1345018	6480464	bisphenol F results in increased expression of OSTM1 protein	CTD	PMID:34186270
Ostm1	Rat	cadmium atom	multiple interactions	ISO	RGD:1345018	6480464	[Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of OSTM1 more ...	CTD	PMID:35301059
Ostm1	Rat	cadmium dichloride	multiple interactions	ISO	RGD:1345018	6480464	[Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of OSTM1 more ...	CTD	PMID:35301059
Ostm1	Rat	caffeine	increases phosphorylation	ISO	RGD:1345018	6480464	Caffeine results in increased phosphorylation of OSTM1 protein	CTD	PMID:35688186
Ostm1	Rat	coumestrol	decreases expression	ISO	RGD:1345018	6480464	Coumestrol results in decreased expression of OSTM1 mRNA	CTD	PMID:19167446
Ostm1	Rat	crocidolite asbestos	increases expression	ISO	RGD:1345018	6480464	Asbestos, Crocidolite results in increased expression of OSTM1 mRNA	CTD	PMID:18687144
Ostm1	Rat	crocin-1	multiple interactions	ISO	RGD:1621630	6480464	[crocin co-treated with pyrazolanthrone co-treated with TNFSF11 protein] results in decreased expression of OSTM1 mRNA; more ...	CTD	PMID:30580027
Ostm1	Rat	cyclosporin A	increases expression	ISO	RGD:1345018	6480464	Cyclosporine results in increased expression of OSTM1 mRNA	CTD	PMID:20106945\|PMID:21632981
Ostm1	Rat	Dibutyl phosphate	affects expression	ISO	RGD:1345018	6480464	di-n-butylphosphoric acid affects the expression of OSTM1 mRNA	CTD	PMID:37042841
Ostm1	Rat	diuron	increases expression	ISO	RGD:1345018	6480464	Diuron metabolite results in increased expression of OSTM1 mRNA	CTD	PMID:24172598
Ostm1	Rat	dorsomorphin	multiple interactions	ISO	RGD:1345018	6480464	[NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased more ...	CTD	PMID:27188386
Ostm1	Rat	doxorubicin	affects expression	ISO	RGD:1345018	6480464	Doxorubicin affects the expression of OSTM1 mRNA	CTD	PMID:25529476
Ostm1	Rat	ethanol	affects splicing	ISO	RGD:1621630	6480464	Ethanol affects the splicing of OSTM1 mRNA	CTD	PMID:30319688
Ostm1	Rat	ethyl methanesulfonate	increases expression	ISO	RGD:1345018	6480464	Ethyl Methanesulfonate results in increased expression of OSTM1 mRNA	CTD	PMID:23649840
Ostm1	Rat	exemestane	increases expression	ISO	RGD:1345018	6480464	exemestane results in increased expression of OSTM1 mRNA	CTD	PMID:17254854
Ostm1	Rat	fenthion	decreases expression	ISO	RGD:1621630	6480464	Fenthion results in decreased expression of OSTM1 mRNA	CTD	PMID:34813904
Ostm1	Rat	finasteride	increases expression	EXP		6480464	Finasteride results in increased expression of OSTM1 mRNA	CTD	PMID:24136188
Ostm1	Rat	fipronil	increases expression	EXP		6480464	fipronil results in increased expression of OSTM1 mRNA	CTD	PMID:34044035
Ostm1	Rat	fluoxetine	increases expression	ISO	RGD:1345018	6480464	Fluoxetine results in increased expression of OSTM1 mRNA	CTD	PMID:37386098
Ostm1	Rat	folic acid	decreases expression	ISO	RGD:1621630	6480464	Folic Acid results in decreased expression of OSTM1 mRNA	CTD	PMID:25629700
Ostm1	Rat	formaldehyde	increases expression	ISO	RGD:1345018	6480464	Formaldehyde results in increased expression of OSTM1 mRNA	CTD	PMID:23649840
Ostm1	Rat	FR900359	increases phosphorylation	ISO	RGD:1345018	6480464	FR900359 results in increased phosphorylation of OSTM1 protein	CTD	PMID:37730182
Ostm1	Rat	fulvestrant	multiple interactions	ISO	RGD:1345018	6480464	[bisphenol A co-treated with Fulvestrant] results in increased methylation of OSTM1 gene	CTD	PMID:31601247
Ostm1	Rat	gentamycin	increases expression	EXP		6480464	Gentamicins results in increased expression of OSTM1 mRNA	CTD	PMID:33387578
Ostm1	Rat	glyphosate	affects methylation	EXP		6480464	Glyphosate affects the methylation of OSTM1 gene	CTD	PMID:31011160
Ostm1	Rat	inulin	multiple interactions	ISO	RGD:1621630	6480464	[perfluorooctane sulfonic acid co-treated with Inulin] results in decreased expression of OSTM1 mRNA	CTD	PMID:36331819
Ostm1	Rat	kojic acid	decreases expression	ISO	RGD:1345018	6480464	kojic acid results in decreased expression of OSTM1 mRNA	CTD	PMID:16595896
Ostm1	Rat	lead(0)	affects expression	ISO	RGD:1345018	6480464	Lead affects the expression of OSTM1 mRNA	CTD	PMID:28903495
Ostm1	Rat	methyl methanesulfonate	increases expression	ISO	RGD:1345018	6480464	Methyl Methanesulfonate results in increased expression of OSTM1 mRNA	CTD	PMID:23649840
Ostm1	Rat	methylglyoxal	multiple interactions	ISO	RGD:1621630	6480464	[TNFSF11 protein co-treated with Pyruvaldehyde] affects the expression of OSTM1 mRNA; [TNFSF11 protein co-treated with more ...	CTD	PMID:30217477\|PMID:31369791
Ostm1	Rat	methylmercury chloride	decreases expression	ISO	RGD:1345018	6480464	methylmercuric chloride results in decreased expression of OSTM1 mRNA	CTD	PMID:28001369
Ostm1	Rat	mifepristone	increases expression	ISO	RGD:1345018	6480464	Mifepristone results in increased expression of OSTM1 mRNA	CTD	PMID:17584828
Ostm1	Rat	paracetamol	increases expression	ISO	RGD:1345018	6480464	Acetaminophen results in increased expression of OSTM1 mRNA	CTD	PMID:22230336
Ostm1	Rat	paracetamol	increases expression	EXP		6480464	Acetaminophen results in increased expression of OSTM1 mRNA	CTD	PMID:33387578
Ostm1	Rat	parathion	decreases expression	ISO	RGD:1621630	6480464	Parathion results in decreased expression of OSTM1 mRNA	CTD	PMID:34813904
Ostm1	Rat	perfluorooctane-1-sulfonic acid	multiple interactions	ISO	RGD:1621630	6480464	[perfluorooctane sulfonic acid co-treated with Inulin] results in decreased expression of OSTM1 mRNA	CTD	PMID:36331819
Ostm1	Rat	phenylmercury acetate	increases expression	ISO	RGD:1345018	6480464	Phenylmercuric Acetate results in increased expression of OSTM1 mRNA	CTD	PMID:26272509
Ostm1	Rat	phenylmercury acetate	multiple interactions	ISO	RGD:1345018	6480464	[NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased more ...	CTD	PMID:27188386
Ostm1	Rat	quercetin	increases expression	ISO	RGD:1345018	6480464	Quercetin results in increased expression of OSTM1 mRNA	CTD	PMID:21632981
Ostm1	Rat	SB 431542	multiple interactions	ISO	RGD:1345018	6480464	[NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased more ...	CTD	PMID:27188386
Ostm1	Rat	sodium arsenite	increases expression	ISO	RGD:1345018	6480464	sodium arsenite results in increased expression of OSTM1 mRNA	CTD	PMID:38568856
Ostm1	Rat	sodium arsenite	multiple interactions	ISO	RGD:1345018	6480464	[sodium arsenite results in increased abundance of Arsenic] which results in decreased expression of OSTM1 more ...	CTD	PMID:39836092
Ostm1	Rat	sulforaphane	increases expression	ISO	RGD:1345018	6480464	sulforaphane results in increased expression of OSTM1 mRNA	CTD	PMID:31838189
Ostm1	Rat	sulindac	increases expression	EXP		6480464	Sulindac results in increased expression of OSTM1 mRNA	CTD	PMID:24136188
Ostm1	Rat	sunitinib	decreases expression	ISO	RGD:1345018	6480464	Sunitinib results in decreased expression of OSTM1 mRNA	CTD	PMID:31533062
Ostm1	Rat	T-2 toxin	decreases expression	ISO	RGD:1345018	6480464	T-2 Toxin results in decreased expression of OSTM1 mRNA	CTD	PMID:31863870
Ostm1	Rat	temozolomide	decreases expression	ISO	RGD:1345018	6480464	Temozolomide results in decreased expression of OSTM1 mRNA	CTD	PMID:31758290
Ostm1	Rat	tetrachloromethane	increases expression	ISO	RGD:1621630	6480464	Carbon Tetrachloride results in increased expression of OSTM1 mRNA	CTD	PMID:31919559
Ostm1	Rat	titanium dioxide	decreases expression	ISO	RGD:1621630	6480464	titanium dioxide results in decreased expression of OSTM1 mRNA	CTD	PMID:29264374
Ostm1	Rat	titanium dioxide	increases methylation	ISO	RGD:1621630	6480464	titanium dioxide results in increased methylation of OSTM1 promoter	CTD	PMID:35295148
Ostm1	Rat	trichloroethene	increases expression	EXP		6480464	Trichloroethylene results in increased expression of OSTM1 mRNA	CTD	PMID:33387578
Ostm1	Rat	valproic acid	affects expression	ISO	RGD:1621630	6480464	Valproic Acid affects the expression of OSTM1 mRNA	CTD	PMID:17963808
Ostm1	Rat	valproic acid	decreases expression	ISO	RGD:1345018	6480464	Valproic Acid results in decreased expression of OSTM1 mRNA	CTD	PMID:28001369
Ostm1	Rat	valproic acid	increases expression	ISO	RGD:1345018	6480464	Valproic Acid results in increased expression of OSTM1 mRNA	CTD	PMID:23179753\|PMID:25192806\|PMID:28001369
Ostm1	Rat	valproic acid	affects expression	ISO	RGD:1345018	6480464	Valproic Acid affects the expression of OSTM1 mRNA	CTD	PMID:25979313
Ostm1	Rat	valproic acid	increases expression	ISO	RGD:1621630	6480464	Valproic Acid results in increased expression of OSTM1 mRNA	CTD	PMID:21427059
Ostm1	Rat	xanthohumol	multiple interactions	ISO	RGD:1621630	6480464	xanthohumol inhibits the reaction [TNFSF11 protein results in increased expression of OSTM1 mRNA]	CTD	PMID:23994090

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Ostm1	Rat	osteoclast differentiation	acts_upstream_of_or_within	IEA	UniProtKB:Q8BGT0\|ensembl:ENSMUSP00000035516	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Ostm1	Rat	osteoclast differentiation	acts_upstream_of_or_within	ISO	RGD:1621630	1624291	MGI:1856885 PMID:12627228	RGD	PMID:12627228
Ostm1	Rat	osteoclast differentiation	involved_in	IBA	MGI:2655574\|PANTHER:PTN000402028	1600115	GO_REF:0000033	GO_Central	GO_REF:0000033
Ostm1	Rat	transepithelial chloride transport	involved_in	ISO	RGD:1345018	1624291	PMID:32851177	RGD	PMID:32851177
Ostm1	Rat	transepithelial chloride transport	involved_in	IEA	UniProtKB:Q86WC4\|ensembl:ENSP00000193322	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107

Cellular Component

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Ostm1	Rat	chloride channel complex	part_of	ISO	RGD:1345018	1624291	PMID:32851177	RGD	PMID:32851177
Ostm1	Rat	chloride channel complex	part_of	IEA	UniProtKB:Q86WC4\|ensembl:ENSP00000193322	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Ostm1	Rat	cytosol	is_active_in	IBA	MGI:2655574\|PANTHER:PTN001038035	1600115	GO_REF:0000033	GO_Central	GO_REF:0000033
Ostm1	Rat	cytosol	located_in	IEA	UniProtKB:Q8BGT0\|ensembl:ENSMUSP00000035516	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Ostm1	Rat	cytosol	located_in	ISO	RGD:1621630	1624291	PMID:12627228	RGD	PMID:12627228
Ostm1	Rat	lysosomal membrane	located_in	ISO	RGD:1345018	1624291	PMID:21527911	RGD	PMID:21527911
Ostm1	Rat	lysosomal membrane	located_in	IEA	UniProtKB:Q86WC4\|ensembl:ENSP00000193322	1600115	GO_REF:0000107	Ensembl	GO_REF:0000107
Ostm1	Rat	membrane	located_in	IEA	UniProtKB-KW:KW-0472	1600115	GO_REF:0000043	UniProt	GO_REF:0000043

Molecular Function

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Ostm1	Rat	protein binding	enables	ISO	RGD:1345018	1624291	UniProtKB:P51798 PMID:32851177, PMID:33961781, PMID:35271311	RGD	PMID:32851177\|PMID:33961781\|PMID:35271311
Ostm1	Rat	protein binding	enables	ISO	RGD:1621630	1624291	UniProtKB:O70496 PMID:16525474	RGD	PMID:16525474

Disease Annotations Click to see Annotation Detail View

autosomal recessive osteopetrosis 5 (ISO,ISS)

Charcot-Marie-Tooth disease type 4 (ISO)

genetic disease (ISO)

osteopetrosis (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(-)-epigallocatechin 3-gallate (ISO)

1,2-dichloroethane (ISO)

1,2-dimethylhydrazine (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

3,4-dichloroaniline (ISO)

acetamide (EXP)

aflatoxin B1 (ISO)

Aflatoxin B2 alpha (ISO)

all-trans-retinoic acid (ISO)

anthra[1,9-cd]pyrazol-6(2H)-one (ISO)

antirheumatic drug (ISO)

apilimod (ISO)

aristolochic acid A (ISO)

arsane (ISO)

arsenic atom (ISO)

avobenzone (ISO)

benzo[a]pyrene (ISO)

benzo[a]pyrene diol epoxide I (ISO)

Bergenin (ISO)

beta-lapachone (ISO)

bis(2-ethylhexyl) phthalate (ISO)

bisphenol A (EXP,ISO)

Bisphenol B (ISO)

bisphenol F (ISO)

cadmium atom (ISO)

cadmium dichloride (ISO)

caffeine (ISO)

coumestrol (ISO)

crocidolite asbestos (ISO)

crocin-1 (ISO)

cyclosporin A (ISO)

Dibutyl phosphate (ISO)

diuron (ISO)

dorsomorphin (ISO)

doxorubicin (ISO)

ethanol (ISO)

ethyl methanesulfonate (ISO)

exemestane (ISO)

fenthion (ISO)

finasteride (EXP)

fipronil (EXP)

fluoxetine (ISO)

folic acid (ISO)

formaldehyde (ISO)

FR900359 (ISO)

fulvestrant (ISO)

gentamycin (EXP)

glyphosate (EXP)

inulin (ISO)

kojic acid (ISO)

lead(0) (ISO)

methyl methanesulfonate (ISO)

methylglyoxal (ISO)

methylmercury chloride (ISO)

mifepristone (ISO)

paracetamol (EXP,ISO)

parathion (ISO)

perfluorooctane-1-sulfonic acid (ISO)

phenylmercury acetate (ISO)

quercetin (ISO)

SB 431542 (ISO)

sodium arsenite (ISO)

sulforaphane (ISO)

sulindac (EXP)

sunitinib (ISO)

T-2 toxin (ISO)

temozolomide (ISO)

tetrachloromethane (ISO)

titanium dioxide (ISO)

trichloroethene (EXP)

valproic acid (ISO)

xanthohumol (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

osteoclast differentiation (IBA,IEA,ISO)

transepithelial chloride transport (IEA,ISO)

Cellular Component

chloride channel complex (IEA,ISO)

cytosol (IBA,IEA,ISO)

lysosomal membrane (IEA,ISO)

membrane (IEA)

Molecular Function

protein binding (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	OMIM Disease Annotation Pipeline	OMIM Disease Annotation Pipeline
3.	GOA pipeline	RGD automated data pipeline
4.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
5.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
6.	Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.	Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.

Additional References at PubMed

PMID:12627228	PMID:12826607	PMID:21527911

Genomics

Comparative Map Data

Ostm1
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	20	47,653,696 - 47,769,248 (+)	NCBI		GRCr8
mRatBN7.2	20	46,071,657 - 46,187,049 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	20	46,153,075 - 46,187,023 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	20	47,870,532 - 47,904,458 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	20	47,520,687 - 47,554,613 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	20	48,212,885 - 48,246,518 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	20	47,394,979 - 47,430,304 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	20	47,395,014 - 47,430,284 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	20	49,062,739 - 49,092,292 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
Celera	20	53,793,629 - 53,820,512 (-)	NCBI		Celera
Cytogenetic Map	20	q13	NCBI

OSTM1
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	6	108,041,409 - 108,074,741 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	6	108,029,245 - 108,165,854 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	6	108,362,613 - 108,395,945 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	6	108,469,306 - 108,502,634 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	6	108,469,305 - 108,502,634	NCBI
Celera	6	109,109,095 - 109,142,438 (-)	NCBI		Celera
Cytogenetic Map	6	q21	NCBI
HuRef	6	105,930,856 - 105,964,198 (-)	NCBI		HuRef
CHM1_1	6	108,625,219 - 108,658,570 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	6	109,218,461 - 109,251,819 (-)	NCBI		T2T-CHM13v2.0

Ostm1
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	10	42,554,912 - 42,578,458 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	10	42,459,818 - 42,578,455 (+)	Ensembl		GRCm39 Ensembl
GRCm38	10	42,678,916 - 42,702,462 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	10	42,583,822 - 42,702,459 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	10	42,398,723 - 42,422,261 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	10	42,367,332 - 42,390,870 (+)	NCBI		MGSCv36	mm8
Celera	10	43,546,113 - 43,569,890 (+)	NCBI		Celera
Cytogenetic Map	10	B2	NCBI
cM Map	10	22.89	NCBI

Ostm1
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955411	33,171,264 - 33,205,486 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955411	33,168,868 - 33,205,452 (-)	NCBI	ChiLan1.0	ChiLan1.0

OSTM1
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	5	128,047,882 - 128,080,071 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	6	125,938,015 - 125,970,220 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	6	105,842,261 - 105,874,429 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	6	109,705,522 - 109,738,691 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	6	109,705,519 - 109,738,691 (-)	Ensembl	panpan1.1		panPan2

OSTM1
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	12	65,085,456 - 65,120,827 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	12	65,087,243 - 65,120,832 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	12	64,901,693 - 64,936,804 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	12	65,961,124 - 65,996,247 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	12	65,961,124 - 65,996,266 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	12	65,317,035 - 65,352,393 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	12	65,162,813 - 65,198,133 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	12	65,436,313 - 65,471,416 (-)	NCBI		UU_Cfam_GSD_1.0

Ostm1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404946	100,026,706 - 100,057,222 (-)	NCBI		HiC_Itri_2
SpeTri2.0	NW_004936564	4,301,569 - 4,332,070 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

OSTM1
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	1	74,139,330 - 74,181,084 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	1	74,139,326 - 74,181,165 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	1	83,410,028 - 83,451,815 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

OSTM1
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	13	65,774,825 - 65,812,606 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	13	65,774,844 - 65,809,272 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666040	38,103,051 - 38,151,291 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Ostm1
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624780	14,212,762 - 14,247,994 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624780	14,212,803 - 14,247,818 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Ostm1
785 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	203
Count of miRNA genes:	150
Interacting mature miRNAs:	169
Transcripts:	ENSRNOT00000057116
Prediction methods:	Microtar, Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
4889610	Pancm3	Pancreatic morphology QTL 3	3.75	0.001	pancreas mass (VT:0010144)	pancreas wet weight (CMO:0000626)	20	17617832	47606836	Rat
2303587	Bw93	Body weight QTL 93	13		body mass (VT:0001259)	body weight (CMO:0000012)	20	25106722	54435887	Rat
1641915	Colcr9	Colorectal carcinoma resistance QTL 9	2.97	0.0024	intestine integrity trait (VT:0010554)	benign colorectal tumor number (CMO:0001795)	20	1530655	46530655	Rat
2305926	Iddm37	Insulin dependent diabetes mellitus QTL 37	6		blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	20	1527842	46527842	Rat
2303626	Vencon10	Ventilatory control QTL 10		0.001	respiration trait (VT:0001943)	respiration rate (CMO:0000289)	20	19190721	54435887	Rat
1598869	Memor6	Memory QTL 6	3.1		exploratory behavior trait (VT:0010471)	total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)	20	29244388	54435887	Rat
7411652	Foco24	Food consumption QTL 24		0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	20	11757515	54435887	Rat
1331747	Hrtrt16	Heart rate QTL 16	3.163		heart pumping trait (VT:2000009)	heart rate (CMO:0000002)	20	25209734	54435887	Rat
1598816	Memor12	Memory QTL 12	2.4		exploratory behavior trait (VT:0010471)	average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)	20	2606836	47606836	Rat
2303578	Gluco50	Glucose level QTL 50	2		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	20	25106722	54435887	Rat
2317880	Alcrsp25	Alcohol response QTL 25	2.3		response to alcohol trait (VT:0010489)	duration of loss of righting reflex (CMO:0002289)	20	17697550	54435887	Rat
9590092	Insglur9	Insulin/glucose ratio QTL 9	18.38	0.001	blood insulin amount (VT:0001560)	calculated plasma insulin level (CMO:0002170)	20	11757515	54435887	Rat
2300188	Bmd68	Bone mineral density QTL 68	6.4	0.0001	femur mineral mass (VT:0010011)	volumetric bone mineral density (CMO:0001553)	20	25106722	54435887	Rat

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	nervous system	renal system	reproductive system	respiratory system
9	11	49	113	91	90	59	25	59	6	218	97	93	45	60	31

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001029925	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006256577	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039099031	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	BC097978	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH474025	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ214266	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000020	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000057116 ⟹ ENSRNOP00000053945

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	20	46,153,075 - 46,186,062 (+)	Ensembl
Rnor_6.0 Ensembl	20	47,395,014 - 47,430,284 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000114998 ⟹ ENSRNOP00000091994

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	20	46,153,148 - 46,187,023 (+)	Ensembl

RefSeq Acc Id:

NM_001029925 ⟹ NP_001025096

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	20	47,735,322 - 47,769,248 (+)	NCBI
mRatBN7.2	20	46,153,122 - 46,187,049 (+)	NCBI
Rnor_6.0	20	47,395,014 - 47,430,284 (+)	NCBI
Rnor_5.0	20	49,062,739 - 49,092,292 (+)	NCBI
Celera	20	53,793,629 - 53,820,512 (-)	RGD

Sequence:

show sequence

GAGCGATCTGGCTGCGGGCCGGCCCCGGGGATGGCTGGGGACGCGGAGCTGGCGCGGCGCGGTG
GGTGGCCGTGGCGGTGGCTGCCGGCGTTGCTGCTGCTGCAACTGCTGCGGTGGAGGTGCGCCCT
GGGCGCGCTCCCCTTCACCAGCAGTCGGCACCCAGGCTTTGCGGACCTGCTGTCGGAGCAGCAG
CTGCTGGAGGTGCAGGACTTGACCCTGTCTCTGCTGCAGGGCGGAGGTCTGGGGCCGCTGTCAC
TGCTACCTCCCGACCTGCCGGATCTGGAGCCTGAATGCCGGGAGCTGCTGATGGACTTCGCCAA
TAGCAGCGCCGAGCTGACCGCCTGTATGGTGCGCAGCGCTCGGCCCGTGCGCCTCTGCCAGACC
TGCTACCCGCTCTTCCAACAGGTCGCAATCAAGATGGACAACATCAGCCGAAACGTCGGGAACG
CCTCCGAGAGCCAGCGCTGTGCAGGAAGTCTCCTGATGGCGGACAGAATGCAGATAGTTGTGAT
GGTCTCTGAGTTCTTCAACAGCACGTGGAAGGAGGCGAACTGTGCAAATTGCCTAACAAAAAAC
AGTGAGGATCTGTCAAATAACACCCAGGACTTCCTCAGTCTGTTTAACAAGACTTTGGCCTGCT
TTGAGCATAACCTGCAGGGGCGCACGTACAGCCTCCCCCCACCAAAGAATTACTCAGAAGTGTG
CAAGAACTGTAAAGAGGCGTACAGAACTCTGAGCCTCCTGTACAGCGAAATGCAGAAAATGAAC
GGGCTGGAGAGCAAGGCGGAGCCGGGAACGCACTTGTGCATCGACGTGGAGGATGCAATGAACA
TTACCCGGAAGCTATGGAGCCGAACCTTCAACTGTTCCGTCACCTGCAGCGACACAGTGTCTGT
GGTTGCCGTTTCCGTGTTCATTCTCTTTCTGCCTGTCGTCTTCTACCTGAGTAGCTTCCTTCAC
TCCGAGCAAAAGAAGCGCAAGCTCATTCTACCCAAACGTCTCAAGTCGAGCACCAGTTTTGCCA
ACATTCAAGAAAATTCCACCTGAAGCCTGCAAAACGGGACTGGACCGCACACCACGCCAATCAG
TGGTTGGACCACAGCAGAGTGGAGAAGATGAGCCGTGATCTGACAAATCAAATTCTTAAGAATC
GCTGGGCTGTGGACCTATAATTTATTCTGAATAAGGGTTCTCAAATTCCCTTTTCCTGAGCACC
CCATCTTTGAAGATTTCTGTATTTTTAATTTTCAGACATAGCAATGTGACACATTTTAAGGTAT
ATCTGTTACAGTAACAAGCGAGGGCTTTTGTTTGTTTTTACAAGAATATGAATGACTACTTGAC
ACTTTTGATATATCCTTGCTAACAGAAATCCACAGAACAGAAACAGCTGAGTTGTGCCAGTTAC
ACACTAGTCAGTCACTGGGAGCCAACCCAGCTCCGAAAAAAAAGAAAAAGAAAAAAAAAAAAAA
AAAAAAAAAAAA

hide sequence

RefSeq Acc Id:

XM_006256577 ⟹ XP_006256639

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	20	47,735,299 - 47,769,248 (+)	NCBI
mRatBN7.2	20	46,153,110 - 46,187,049 (+)	NCBI
Rnor_6.0	20	47,394,979 - 47,430,304 (+)	NCBI
Rnor_5.0	20	49,062,739 - 49,092,292 (+)	NCBI

Sequence:

show sequence

GAAGCCGGAAGCGGCTGCTGTCGGAAGCACCGGGCGAGCGATCTGGCTGCGGGGCCGGCCCCGG
GGATGGCTGGGGACGCGGAGCTGGCGCGGCGCGGTGGGTGGCCGTGGCGGTGGCTGCCGGCGTT
GCTGCTGCTGCAACTGCTGCGGTGGAGGTGCGCCCTGGGCGCGCTCCCCTTCACCAGCAGTCGG
CACCCAGGCTTTGCGGACCTGCTGTCGGAGCAGCAGCTGCTGGAGGTGCAGGACTTGACCCTGT
CTCTGCTGCAGGGCGGAGGTCTGGGGCCGCTGTCACTGCTACCTCCCGACCTGCCGGATCTGGA
GCCTGAATGCCGGGAGCTGCTGATGGACTTCGCCAATAGCAGCGCCGAGCTGACCGCCTGTATG
GTGCGCAGCGCTCGGCCCGTGCGCCTCTGCCAGACCTGCTACCCGCTCTTCCAACAGGTCGCAA
TCAAGATGGACAACATCAGCCGAAACGTCGGGGTGGGTAGAGGAGCAGACTGTGGCGTGGGAGC
TGGGAAAAACGCCTCCGAGAGCCAGCGCTGTGCAGGAAGTCTCCTGATGGCGGACAGAATGCAG
ATAGTTGTGATGGTCTCTGAGTTCTTCAACAGCACGTGGAAGGAGGCGAACTGTGCAAATTGCC
TAACAAAAAACAGTGAGGATCTGTCAAATAACACCCAGGACTTCCTCAGTCTGTTTAACAAGAC
TTTGGCCTGCTTTGAGCATAACCTGCAGGGGCGCACGTACAGCCTCCCCCCACCAAAGAATTAC
TCAGAAGTGTGCAAGAACTGTAAAGAGGCGTACAGAACTCTGAGCCTCCTGTACAGCGAAATGC
AGAAAATGAACGGGCTGGAGAGCAAGGCGGAGCCGGGAACGCACTTGTGCATCGACGTGGAGGA
TGCAATGAACATTACCCGGAAGCTATGGAGCCGAACCTTCAACTGTTCCGTCACCTGCAGCGAC
ACAGTGTCTGTGGTTGCCGTTTCCGTGTTCATTCTCTTTCTGCCTGTCGTCTTCTACCTGAGTA
GCTTCCTTCACTCCGAGCAAAAGAAGCGCAAGCTCATTCTACCCAAACGTCTCAAGTCGAGCAC
CAGTTTTGCCAACATTCAAGAAAATTCCACCTGAAGCCTGCAAAACGGGACTGGACCGCACACC
ACGCCAATCAGTGGTTGGACCACAGCAGAGTGGAGAAGATGAGCCGTGATCTGACAAATCAAAT
TCTTAAGAATCGCTGGGCTGTGGACCTATAATTTATTCTGAATAAGGGTTCTCAAATTCCCTTT
TCCTGAGCACCCCATCTTTGAAGATTTCTGTATTTTTAATTTTCAGACATAGCAATGTGACACA
TTTTAAGGTATATCTGTTACAGTAACAAGCGAGGGCTTTTGTTTGTTTTTACAAGAATATGAAT
GACTACTTGACACTTTTGATATATCCTTGCTAACAGAAATCCACAGAACAGAAACAGCTGAGTT
GTGCCAGTTACACACTAGTCAGTCACTGGGAGCCAAGCCAGCTTTGAAAAGGAAATACACGGG

hide sequence

RefSeq Acc Id:

XM_039099031 ⟹ XP_038954959

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	20	47,653,696 - 47,769,248 (+)	NCBI
mRatBN7.2	20	46,071,657 - 46,187,049 (+)	NCBI

Protein Sequences


Protein RefSeqs	NP_001025096	(Get FASTA)	NCBI Sequence Viewer
	XP_006256639	(Get FASTA)	NCBI Sequence Viewer
	XP_038954959	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAH97978	(Get FASTA)	NCBI Sequence Viewer
	EDL99701	(Get FASTA)	NCBI Sequence Viewer
	EDL99702	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000053945.4
	ENSRNOP00000091994
	ENSRNOP00000091994.1

RefSeq Acc Id:	NP_001025096 ⟸ NM_001029925
- Peptide Label:	precursor
- UniProtKB:	Q4QQU9 (UniProtKB/TrEMBL), F1LP89 (UniProtKB/TrEMBL)
- Sequence:	show sequence MAGDAELARRGGWPWRWLPALLLLQLLRWRCALGALPFTSSRHPGFADLLSEQQLLEVQDLTLS LLQGGGLGPLSLLPPDLPDLEPECRELLMDFANSSAELTACMVRSARPVRLCQTCYPLFQQVAI KMDNISRNVGNASESQRCAGSLLMADRMQIVVMVSEFFNSTWKEANCANCLTKNSEDLSNNTQD FLSLFNKTLACFEHNLQGRTYSLPPPKNYSEVCKNCKEAYRTLSLLYSEMQKMNGLESKAEPGT HLCIDVEDAMNITRKLWSRTFNCSVTCSDTVSVVAVSVFILFLPVVFYLSSFLHSEQKKRKLIL PKRLKSSTSFANIQENST hide sequence

RefSeq Acc Id:	XP_006256639 ⟸ XM_006256577
- Peptide Label:	isoform X1
- UniProtKB:	A0A8J8Y8J8 (UniProtKB/TrEMBL)
- Sequence:	show sequence MAGDAELARRGGWPWRWLPALLLLQLLRWRCALGALPFTSSRHPGFADLLSEQQLLEVQDLTLS LLQGGGLGPLSLLPPDLPDLEPECRELLMDFANSSAELTACMVRSARPVRLCQTCYPLFQQVAI KMDNISRNVGVGRGADCGVGAGKNASESQRCAGSLLMADRMQIVVMVSEFFNSTWKEANCANCL TKNSEDLSNNTQDFLSLFNKTLACFEHNLQGRTYSLPPPKNYSEVCKNCKEAYRTLSLLYSEMQ KMNGLESKAEPGTHLCIDVEDAMNITRKLWSRTFNCSVTCSDTVSVVAVSVFILFLPVVFYLSS FLHSEQKKRKLILPKRLKSSTSFANIQENST hide sequence

Ensembl Acc Id:

ENSRNOP00000053945 ⟸ ENSRNOT00000057116

RefSeq Acc Id:	XP_038954959 ⟸ XM_039099031
- Peptide Label:	isoform X2

Ensembl Acc Id:

ENSRNOP00000091994 ⟸ ENSRNOT00000114998

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q4QQU9-F1-model_v2	AlphaFold	Q4QQU9	1-338	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13701670

Promoter ID:

EPDNEW_R12194

Type:

multiple initiation site

Name:

Ostm1_1

Description:

osteopetrosis associated transmembrane protein 1

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	20	47,394,995 - 47,395,055	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1564976	AgrOrtholog
BioCyc Gene	G2FUF-3357	BioCyc
Ensembl Genes	ENSRNOG00000037647	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000057116.4	UniProtKB/TrEMBL
	ENSRNOT00000114998	ENTREZGENE
	ENSRNOT00000114998.1	UniProtKB/TrEMBL
IMAGE_CLONE	IMAGE:7442765	IMAGE-MGC_LOAD
InterPro	Osteopetrosis-assoc_TM_1	UniProtKB/TrEMBL
KEGG Report	rno:499474	UniProtKB/TrEMBL
MGC_CLONE	MGC:116111	IMAGE-MGC_LOAD
NCBI Gene	499474	ENTREZGENE
PANTHER	OSTEOPETROSIS-ASSOCIATED TRANSMEMBRANE PROTEIN 1	UniProtKB/TrEMBL
	PTHR15644	UniProtKB/TrEMBL
Pfam	OSTMP1	UniProtKB/TrEMBL
PhenoGen	Ostm1	PhenoGen
RatGTEx	ENSRNOG00000037647	RatGTEx
UniProt	A0A8J8Y8J8	ENTREZGENE, UniProtKB/TrEMBL
	F1LP89	ENTREZGENE
	Q4QQU9	ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary	F1LP89	UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2018-08-21	Ostm1	osteoclastogenesis associated transmembrane protein 1	Ostm1	osteopetrosis associated transmembrane protein 1	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-03-05	Ostm1	osteopetrosis associated transmembrane protein 1	LOC499474	similar to osteopetrosis associated transmembrane protein 1	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2006-02-09	LOC499474	similar to osteopetrosis associated transmembrane protein 1			Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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