Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   
Gene: Cdk1 (cyclin-dependent kinase 1) Rattus norvegicus
Symbol: Cdk1
Name: cyclin-dependent kinase 1
Description: Exhibits cyclin binding activity; cyclin-dependent protein serine/threonine kinase activity; and histone kinase activity. Involved in several processes, including Golgi disassembly; positive regulation of macromolecule metabolic process; and positive regulation of protein import into nucleus. Localizes to cytoplasm and nucleus. Predicted to colocalize with mitochondrial matrix. Biomarker of hepatocellular carcinoma. Human ortholog(s) of this gene implicated in breast cancer; cervical cancer; and urinary bladder cancer. Orthologous to human CDK1 (cyclin dependent kinase 1); PARTICIPATES IN cell cycle pathway, mitotic; G1/S transition pathway; G2/M checkpoint pathway; INTERACTS WITH (+)-catechin; (+)-pilocarpine; (R)-mevalonic acid.
Type: protein-coding
Also known as: Cdc2; Cdc2a; cell division control protein 2 homolog; cell division cycle 2; cell division cycle 2 homolog A; cell division cycle 2 homolog A (S. pombe); cell division cycle 2, G1 to S and G2 to M; Cell division cycle control protein 2; cell division protein kinase 1; p34 protein kinase
Homo sapiens (human) : CDK1 (cyclin dependent kinase 1)  HGNC  Alliance
Mus musculus (house mouse) : Cdk1 (cyclin-dependent kinase 1)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Cdk1 (cyclin dependent kinase 1)
Pan paniscus (bonobo/pygmy chimpanzee) : CDK1 (cyclin dependent kinase 1)
Canis lupus familiaris (dog) : CDK1 (cyclin dependent kinase 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Cdk1 (cyclin dependent kinase 1)
Sus scrofa (pig) : CDK1 (cyclin dependent kinase 1)
Chlorocebus sabaeus (African green monkey) : CDK1 (cyclin dependent kinase 1)
Heterocephalus glaber (naked mole-rat) : Cdk1 (cyclin dependent kinase 1)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.02020,576,341 - 20,591,510 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2020,576,377 - 20,591,549 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02022,694,883 - 22,709,860 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42020,018,044 - 20,044,030 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.12020,031,843 - 20,057,830 (+)NCBI
Celera2020,642,946 - 20,658,475 (+)NCBICelera
Cytogenetic Map20p11NCBI
RH 3.4 Map20252.37RGD
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Cdk1
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 2319
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2020-06-09
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.