Cdk1 (cyclin-dependent kinase 1) - Rat Genome Database
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Gene: Cdk1 (cyclin-dependent kinase 1) Rattus norvegicus
Analyze
Symbol: Cdk1
Name: cyclin-dependent kinase 1
RGD ID: 2319
Description: Exhibits cyclin binding activity; cyclin-dependent protein serine/threonine kinase activity; and histone kinase activity. Involved in several processes, including Golgi disassembly; positive regulation of macromolecule metabolic process; and positive regulation of protein import into nucleus. Localizes to cytoplasm and nucleus. Predicted to colocalize with mitochondrial matrix. Biomarker of hepatocellular carcinoma. Human ortholog(s) of this gene implicated in breast cancer; cervical cancer; and urinary bladder cancer. Orthologous to human CDK1 (cyclin dependent kinase 1); PARTICIPATES IN cell cycle pathway, mitotic; G1/S transition pathway; G2/M checkpoint pathway; INTERACTS WITH (+)-catechin; (+)-pilocarpine; (R)-mevalonic acid.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: Cdc2; Cdc2a; cell division control protein 2 homolog; cell division cycle 2; cell division cycle 2 homolog A; cell division cycle 2 homolog A (S. pombe); cell division cycle 2, G1 to S and G2 to M; Cell division cycle control protein 2; cell division protein kinase 1; p34 protein kinase
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.22019,266,226 - 19,281,417 (+)NCBI
Rnor_6.0 Ensembl2020,576,377 - 20,591,549 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.02020,576,341 - 20,591,510 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.02022,694,883 - 22,709,860 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42020,018,044 - 20,044,030 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.12020,031,843 - 20,057,830 (+)NCBI
Celera2020,642,946 - 20,658,475 (+)NCBICelera
RH 3.4 Map20252.37RGD
Cytogenetic Map20p11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-catechin  (EXP)
(+)-pilocarpine  (EXP)
(-)-citrinin  (ISO)
(-)-demecolcine  (ISO)
(1S)-bornane-2,3-dione  (ISO)
(20R)-protopanaxadiol  (ISO)
(R)-mevalonic acid  (EXP)
1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane  (ISO)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (EXP,ISO)
1,1-dichloroethene  (ISO)
1,2-dimethylhydrazine  (ISO)
1,3-dinitrobenzene  (EXP,ISO)
1-chloro-2,4-dinitrobenzene  (ISO)
1-naphthyl isothiocyanate  (EXP)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrotoluene  (EXP)
2-acetamidofluorene  (EXP)
2-amino-2-deoxy-D-glucopyranose  (EXP)
2-methoxy-17beta-estradiol  (ISO)
2-methylcholine  (ISO)
2-nitrofluorene  (EXP)
2-trans,6-trans,10-trans-geranylgeranyl diphosphate  (EXP)
3',4',5-trihydroxy-3,7-dimethoxyflavone  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3,3',5,5'-tetrabromobisphenol A  (EXP)
3-[(4-anilinophenyl)diazenyl]benzene-1-sulfonic acid  (EXP)
4,4'-diaminodiphenylmethane  (EXP)
4-(ethoxymethylene)-2-phenyloxazol-5-one  (ISO)
4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one  (EXP)
4-hydroxyphenyl retinamide  (ISO)
5-aza-2'-deoxycytidine  (EXP,ISO)
5-azacytidine  (ISO)
5-fluorouracil  (ISO)
5-formyltetrahydrofolic acid  (ISO)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
acrylamide  (EXP)
afimoxifene  (ISO)
aflatoxin B1  (EXP,ISO)
aflatoxin M1  (ISO)
alachlor  (EXP)
aldehydo-D-glucosamine  (EXP)
all-trans-retinoic acid  (EXP,ISO)
alpha-hexylcinnamaldehyde  (ISO)
alpha-naphthoflavone  (ISO)
alvocidib  (ISO)
amifostine  (ISO)
ammonium chloride  (EXP)
anthocyanin  (ISO)
anthra[1,9-cd]pyrazol-6(2H)-one  (ISO)
apigenin  (ISO)
arecoline  (ISO)
aristolochic acid  (EXP)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (EXP,ISO)
atenolol  (ISO)
atrazine  (ISO)
atropine  (ISO)
auraptene  (ISO)
azathioprine  (ISO)
baicalein  (ISO)
belinostat  (ISO)
benzene  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[b]fluoranthene  (ISO)
benzophenone  (EXP)
beta-D-glucosamine  (EXP)
beta-naphthoflavone  (EXP)
bexarotene  (ISO)
bicalutamide  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
Bisphenol A glycidylmethacrylate  (ISO)
Bisphenol B  (ISO)
bortezomib  (ISO)
bryostatin 1  (ISO)
buspirone  (EXP)
buta-1,3-diene  (ISO)
butylated hydroxyanisole  (EXP)
cadmium atom  (EXP,ISO)
cadmium dichloride  (EXP,ISO)
caffeine  (ISO)
calcitriol  (ISO)
camptothecin  (ISO)
cannabidiol  (ISO)
capsaicin  (EXP)
carbon nanotube  (ISO)
catechol  (EXP)
cefaloridine  (EXP)
chlorambucil  (ISO)
chlorendic acid  (EXP)
chloroprene  (ISO)
choline  (ISO)
chromium atom  (ISO)
chromium(6+)  (EXP)
ciglitazone  (ISO)
ciprofloxacin  (EXP)
cisplatin  (ISO)
clofibrate  (ISO)
clotrimazole  (ISO)
cobalt dichloride  (ISO)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
copper(II) sulfate  (ISO)
corosolic acid  (ISO)
corticosterone  (EXP)
coumestrol  (ISO)
crocidolite asbestos  (ISO)
CU-O LINKAGE  (ISO)
cucurbitacin I  (ISO)
curcumin  (EXP,ISO)
cyclosporin A  (ISO)
cytochalasin B  (ISO)
deoxynivalenol  (ISO)
dexamethasone  (EXP,ISO)
diallyl disulfide  (ISO)
diallyl trisulfide  (ISO)
diarsenic trioxide  (EXP,ISO)
diazinon  (EXP)
dibenz[a,h]anthracene  (ISO)
dibutyl phthalate  (EXP)
dicrotophos  (ISO)
dieldrin  (EXP)
diepoxybutane  (ISO)
diethylstilbestrol  (EXP)
digitoxin  (ISO)
dioscin  (ISO)
dioxygen  (EXP,ISO)
diuron  (EXP)
dorsomorphin  (ISO)
doxorubicin  (EXP,ISO)
elemental selenium  (ISO)
ellagic acid  (ISO)
ellipticine  (ISO)
endosulfan  (EXP)
Enterolactone  (ISO)
enzyme inhibitor  (ISO)
erythromycin estolate  (EXP)
ethanol  (ISO)
fenbendazole  (EXP)
fipronil  (EXP)
fisetin  (ISO)
flumequine  (ISO)
folic acid  (ISO)
fulvestrant  (ISO)
furan  (EXP)
gamma-linolenic acid  (ISO)
gamma-tocopherol  (ISO)
genistein  (ISO)
geraniol  (ISO)
gingerol  (ISO)
glycidol  (EXP)
Goe 6976  (ISO)
gold atom  (ISO)
gold(0)  (ISO)
guggulsterone  (ISO)
GW 4064  (ISO)
harmine  (ISO)
hellebrigenin  (ISO)
hydrogen peroxide  (ISO)
hydroxamic acid  (EXP)
inuviscolide  (ISO)
irinotecan  (EXP,ISO)
isoprenaline  (ISO)
kaempferol  (ISO)
ketamine  (EXP)
L-ascorbic acid  (EXP)
L-methionine  (ISO)
lead diacetate  (EXP)
leflunomide  (EXP,ISO)
leptomycin B  (ISO)
levofloxacin  (EXP)
limonene  (EXP)
lipopolysaccharide  (ISO)
Longikaurin A  (ISO)
lucanthone  (ISO)
luteolin  (ISO)
lycopene  (ISO)
malachite green cation  (EXP)
mangiferin  (ISO)
mechlorethamine  (ISO)
MeIQx  (ISO)
melatonin  (ISO)
mercury dichloride  (EXP)
metformin  (ISO)
methamphetamine  (EXP)
methapyrilene  (EXP)
methotrexate  (ISO)
methyl salicylate  (ISO)
methylmercury chloride  (ISO)
methylparaben  (ISO)
methylseleninic acid  (ISO)
microcystin-LR  (ISO)
mifepristone  (ISO)
mitomycin C  (ISO)
ML-7  (EXP)
morin  (ISO)
N-acetyl-L-cysteine  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-methyl-4-phenylpyridinium  (EXP,ISO)
N-methyl-N-nitrosourea  (EXP,ISO)
N-nitrosodiethylamine  (EXP,ISO)
N-nitrosodimethylamine  (EXP)
N-Nitrosopyrrolidine  (ISO)
naphthalene  (EXP,ISO)
nickel atom  (ISO)
nickel subsulfide  (EXP)
nimesulide  (EXP)
nitroprusside  (ISO)
nocodazole  (ISO)
nonanoic acid  (ISO)
O-methyleugenol  (EXP)
ochratoxin A  (EXP,ISO)
okadaic acid  (ISO)
olomoucine  (ISO)
omacetaxine mepesuccinate  (ISO)
orlistat  (ISO)
osthole  (ISO)
oxaliplatin  (EXP,ISO)
ozone  (ISO)
paclitaxel  (ISO)
palbociclib  (ISO)
Panduratin A  (ISO)
paracetamol  (ISO)
paraquat  (ISO)
parathion  (ISO)
PCB138  (ISO)
Pentoxifylline  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
PF-00477736  (ISO)
phenethyl caffeate  (ISO)
phenethyl isothiocyanate  (EXP)
phenformin  (EXP)
phenobarbital  (EXP,ISO)
phenytoin  (ISO)
PhIP  (EXP,ISO)
phorbol 13-acetate 12-myristate  (ISO)
phthalaldehyde  (ISO)
phytoestrogen  (ISO)
picropodophyllotoxin  (ISO)
piperine  (ISO)
piperonyl butoxide  (EXP)
Pirarubicin  (ISO)
pirinixic acid  (EXP,ISO)
piroxicam  (ISO)
poly(propylene imine) macromolecule  (ISO)
potassium bromate  (ISO)
potassium dichromate  (EXP)
pregnenolone 16alpha-carbonitrile  (ISO)
procyanidin  (ISO)
progesterone  (EXP,ISO)
propanal  (ISO)
propiconazole  (ISO)
propofol  (ISO)
quercetin  (EXP,ISO)
quinolines  (ISO)
reactive oxygen species  (ISO)
resveratrol  (EXP,ISO)
rotenone  (EXP)
saccharin  (ISO)
SB 203580  (ISO)
selenium atom  (ISO)
silibinin  (ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
silver(1+) nitrate  (ISO)
simvastatin  (EXP,ISO)
sirolimus  (EXP,ISO)
sodium arsenite  (EXP,ISO)
sodium dichromate  (EXP,ISO)
Soman  (EXP)
sorafenib  (ISO)
SR 144528  (ISO)
sterigmatocystin  (ISO)
sulfadimethoxine  (EXP)
sulforaphane  (ISO)
sulindac  (ISO)
sunitinib  (ISO)
tamoxifen  (EXP,ISO)
tanespimycin  (ISO)
temozolomide  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone  (ISO)
testosterone enanthate  (ISO)
tetrachloromethane  (EXP,ISO)
thalidomide  (ISO)
thapsigargin  (ISO)
thimerosal  (ISO)
thioacetamide  (EXP)
titanium dioxide  (EXP,ISO)
tocopherol  (ISO)
toluene 2,4-diisocyanate  (ISO)
Tomentosin  (ISO)
topotecan  (EXP)
trabectedin  (EXP)
triazoles  (ISO)
Tributyltin oxide  (EXP)
trichloroethene  (EXP,ISO)
trichostatin A  (ISO)
trimellitic anhydride  (ISO)
Triptolide  (EXP,ISO)
troglitazone  (ISO)
tropan-3alpha-yl 3-hydroxy-2-phenylpropanoate  (ISO)
trovafloxacin  (EXP)
tungsten  (ISO)
tunicamycin  (ISO)
tyrphostin AG 1478  (ISO)
urethane  (ISO)
vincaleukoblastine  (ISO)
vincristine  (ISO)
vorinostat  (ISO)
wortmannin  (ISO)
Xanthatin  (ISO)
zaragozic acid A  (EXP,ISO)
zidovudine  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
animal organ regeneration  (IMP)
apoptotic process  (IEA)
cell aging  (IDA)
cell division  (IEA)
cell population proliferation  (ISO)
cellular response to hydrogen peroxide  (IEP)
chromosome condensation  (IMP)
epithelial cell differentiation  (ISO)
G2/M transition of mitotic cell cycle  (IBA)
Golgi disassembly  (IDA)
histone phosphorylation  (IEA)
meiotic cell cycle process involved in oocyte maturation  (ISO)
meiotic spindle organization  (ISO)
mitotic cell cycle  (IEP)
mitotic cell cycle phase transition  (ISO)
mitotic G2 DNA damage checkpoint signaling  (IBA,ISO)
negative regulation of apoptotic process  (ISO)
negative regulation of gene expression  (IMP)
peptidyl-serine phosphorylation  (IDA,ISO,ISS)
peptidyl-threonine phosphorylation  (ISO,ISS)
positive regulation of cardiac muscle cell proliferation  (IMP)
positive regulation of DNA replication  (IMP)
positive regulation of G2/M transition of mitotic cell cycle  (ISO)
positive regulation of gene expression  (IMP)
positive regulation of meiotic cell cycle process involved in oocyte maturation  (ISO)
positive regulation of mitochondrial ATP synthesis coupled electron transport  (ISO)
positive regulation of mitotic cell cycle  (IMP)
positive regulation of protein import into nucleus  (IMP)
positive regulation of protein localization to nucleus  (ISO)
protein localization to kinetochore  (ISO)
protein phosphorylation  (IBA,ISO)
protein-containing complex assembly  (IDA)
regulation of circadian rhythm  (ISO,ISS)
response to activity  (IEP)
response to amine  (IEP)
response to axon injury  (IEP)
response to cadmium ion  (IEP)
response to copper ion  (IEP)
response to drug  (IEP)
response to ethanol  (IDA)
response to hydrogen peroxide  (IEP)
response to organic cyclic compound  (IEP)
response to organonitrogen compound  (IDA)
response to toxic substance  (IEP)
rhythmic process  (IEA)
ventricular cardiac muscle cell development  (IEP)

Cellular Component

References

References - curated
1. Adler M, etal., Carcinogenesis. 2009 Apr;30(4):711-9. Epub 2009 Feb 23.
2. Badea TC, etal., J Biol Chem 1998 Oct 9;273(41):26977-81.
3. Bicknell KA, etal., Biochem J. 2004 Sep 1;382(Pt 2):411-6.
4. Calvisi DF, etal., Gut. 2009 May;58(5):679-87. Epub 2009 Jan 9.
5. Cobelens PM, etal., Cell Signal. 2007 Feb;19(2):269-77. Epub 2006 Sep 11.
6. Donald S, etal., Cancer Res 2002 Aug 1;62(15):4256-62.
7. Garnier D, etal., Hepatology. 2009 Dec;50(6):1946-56.
8. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
9. Gu L, etal., Antioxid Redox Signal. 2017 Nov 10;27(14):1013-1026. doi: 10.1089/ars.2016.6880. Epub 2017 Mar 28.
10. Han IS, etal., J Cell Sci. 2007 Jan 15;120(Pt 2):246-55. Epub 2007 Jan 2.
11. Holyoake A, etal., Clin Cancer Res. 2008 Feb 1;14(3):742-9.
12. Ito J, etal., Reproduction. 2005 Feb;129(2):171-80.
13. Jones MK, etal., J Cell Physiol. 2008 Jun;215(3):750-64.
14. Kim MR, etal., Exp Mol Med. 2005 Aug 31;37(4):335-42.
15. Kim SJ, etal., Ann Oncol. 2008 Jan;19(1):68-72. Epub 2007 Oct 22.
16. Kwitek AE, etal., Genome Res. 2004 Apr;14(4):750-7
17. Lokeshwar VB, etal., Cancer Res. 2006 Dec 1;66(23):11219-27.
18. Lowe M, etal., Cell 1998 Sep 18;94(6):783-93.
19. MGD data from the GO Consortium
20. NCBI rat LocusLink and RefSeq merged data July 26, 2002
21. Olson JE, etal., Breast Cancer Res Treat. 2010 Jan;119(2):423-30. Epub 2009 Apr 18.
22. Pipeline to import KEGG annotations from KEGG into RGD
23. Raina K, etal., Cancer Res. 2007 Jun 15;67(12):5976-82.
24. Rao HV, etal., Neurosci Lett. 2009 Feb 6;450(3):347-50. Epub 2008 Dec 16.
25. Reactome
26. RGD automated data pipeline
27. RGD automated import pipeline for gene-chemical interactions
28. Seo TB, etal., J Pharmacol Sci. 2009 Aug;110(4):483-92.
29. Seo TB, etal., Med Sci Sports Exerc. 2006 Jul;38(7):1267-76.
30. Seomun Y, etal., Mol Vis. 2005 Sep 16;11:764-74.
31. Shima T, etal., Chem Biol Interact. 2009 Jul 15;180(2):262-70. Epub 2009 Feb 13.
32. Shimizu M, etal., Mol Cell Biol 1995 May;15(5):2882-92.
33. Starkel P, etal., Lab Invest. 2005 Apr;85(4):562-71.
34. Swierczynski SL, etal., Hum Pathol. 2004 Mar;35(3):357-66.
35. Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
36. Ueno M, etal., Exp Neurol. 2006 Mar;198(1):154-66. Epub 2006 Jan 19.
37. Vandyke K, etal., Neoplasia. 2007 Apr;9(4):322-31.
38. Woo GH, etal., Cancer Sci. 2009 Apr;100(4):617-25. Epub 2009 Feb 25.
39. Xie J and Shaikh ZA, Toxicology. 2006 Jul 5;224(1-2):56-65. Epub 2006 Apr 27.
40. Yuan Z, etal., Science. 2008 Mar 21;319(5870):1665-8.
41. Zempolich K, etal., Gynecol Oncol. 2008 May;109(2):275-9. Epub 2008 Mar 4.
Additional References at PubMed
PMID:1312467   PMID:2541912   PMID:7739547   PMID:9247342   PMID:9344597   PMID:9438384   PMID:11069302   PMID:11298763   PMID:12124778   PMID:12477932   PMID:12721286   PMID:12937170  
PMID:15337841   PMID:15678101   PMID:15767402   PMID:16109376   PMID:17488717   PMID:18195732   PMID:18477460   PMID:18624766   PMID:18625720   PMID:19056867   PMID:19135898   PMID:19139267  
PMID:19187565   PMID:19550110   PMID:19879842   PMID:19946888   PMID:20071461   PMID:21492153   PMID:21778139   PMID:21871177   PMID:22405274   PMID:22674394   PMID:22848730   PMID:22854038  
PMID:23331249   PMID:23360302   PMID:23509069   PMID:23574715   PMID:23601106   PMID:24374180   PMID:24746669   PMID:24859236   PMID:26051540   PMID:26109654   PMID:26982431   PMID:27030108  
PMID:27238018  


Genomics

Comparative Map Data
Cdk1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.22019,266,226 - 19,281,417 (+)NCBI
Rnor_6.0 Ensembl2020,576,377 - 20,591,549 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.02020,576,341 - 20,591,510 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.02022,694,883 - 22,709,860 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42020,018,044 - 20,044,030 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.12020,031,843 - 20,057,830 (+)NCBI
Celera2020,642,946 - 20,658,475 (+)NCBICelera
RH 3.4 Map20252.37RGD
Cytogenetic Map20p11NCBI
CDK1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1060,778,331 - 60,794,852 (+)EnsemblGRCh38hg38GRCh38
GRCh381060,778,331 - 60,794,852 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371062,538,089 - 62,554,610 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361062,205,690 - 62,223,930 (+)NCBINCBI36hg18NCBI36
Build 341062,209,916 - 62,223,930NCBI
Celera1055,803,740 - 55,820,255 (+)NCBI
Cytogenetic Map10q21.2NCBI
HuRef1056,527,463 - 56,544,301 (+)NCBIHuRef
CHM1_11062,820,315 - 62,836,829 (+)NCBICHM1_1
Cdk1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391069,170,976 - 69,188,742 (-)NCBIGRCm39mm39
GRCm39 Ensembl1069,170,976 - 69,188,768 (-)Ensembl
GRCm381069,335,146 - 69,352,912 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1069,335,146 - 69,352,938 (-)EnsemblGRCm38mm10GRCm38
MGSCv371068,799,383 - 68,815,660 (-)NCBIGRCm37mm9NCBIm37
MGSCv361068,731,992 - 68,748,269 (-)NCBImm8
Celera1070,426,785 - 70,443,097 (-)NCBICelera
Cytogenetic Map10B5.3NCBI
cM Map1036.07NCBI
Cdk1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542514,210,680 - 14,226,474 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495542514,210,681 - 14,226,474 (+)NCBIChiLan1.0ChiLan1.0
CDK1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11059,647,993 - 59,664,434 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1059,647,993 - 59,664,434 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01057,314,692 - 57,331,261 (+)NCBIMhudiblu_PPA_v0panPan3
CDK1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl412,883,385 - 12,899,197 (+)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.1412,884,106 - 12,899,203 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Cdk1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_0049366142,300,682 - 2,313,611 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CDK1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1464,233,988 - 64,395,453 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11464,233,945 - 64,255,290 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21469,262,279 - 69,277,262 (+)NCBISscrofa10.2Sscrofa10.2susScr3
CDK1
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1970,475,736 - 70,492,947 (-)NCBI
Cdk1
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247912,891,239 - 2,915,001 (-)NCBI

Position Markers
RH94872  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.02020,591,343 - 20,591,442NCBIRnor6.0
Rnor_5.02022,709,693 - 22,709,792UniSTSRnor5.0
RGSC_v3.42020,043,864 - 20,043,963UniSTSRGSC3.4
Celera2020,658,309 - 20,658,408UniSTS
RH 3.4 Map20252.37UniSTS
Cytogenetic Map20p11UniSTS


QTLs in Region (Rnor_6.0)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1354642Despr15Despair related QTL 150.0027locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)20124652101Rat
1600382Edcs3Endometrial carcinoma susceptibility QTL33.50.003uterus morphology trait (VT:0001120)percentage of study population developing endometrioid carcinoma during a period of time (CMO:0001759)20125653396Rat
1641893Alcrsp7Alcohol response QTL 7response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)20126305996Rat
2317851Alcrsp22Alcohol response QTL 223.20.05response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)20126305996Rat
7387283Uae44Urinary albumin excretion QTL 440.1712urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)20127357423Rat
9590275Scort15Serum corticosterone level QTL 153.480.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)20128375393Rat
9589155Insul32Insulin level QTL 326.380.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)20128375393Rat
9590109Sffal8Serum free fatty acids level QTL 85.320.01blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)20128375393Rat
7411650Foco23Food consumption QTL 2320.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)20128375393Rat
8694189Bw153Body weight QTL 1533.130.001body mass (VT:0001259)body weight gain (CMO:0000420)20128375393Rat
6893685Bw111Body weight QTL 1112.70.004body mass (VT:0001259)body weight (CMO:0000012)20133300419Rat
9590252Scort12Serum corticosterone level QTL 1220.460.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)20137550487Rat
7411668Foco32Food consumption QTL 3280.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)20137550487Rat
2305926Iddm37Insulin dependent diabetes mellitus QTL 376blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)20201865447018654Rat
1641915Colcr9Colorectal carcinoma resistance QTL 92.970.0024intestine integrity trait (VT:0010554)benign colorectal tumor number (CMO:0001795)20299970747999707Rat
2317057Aia27Adjuvant induced arthritis QTL 272.83joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)20340211127968216Rat
1598816Memor12Memory QTL 122.4exploratory behavior trait (VT:0010471)average horizontal distance in proximity to the target during voluntary locomotion in an experimental apparatus (CMO:0002674)20410895649108956Rat
4889870Pur30Proteinuria QTL 30190.005total urine protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)20865434130991290Rat
9590092Insglur9Insulin/glucose ratio QTL 918.380.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)201383430956205956Rat
7411652Foco24Food consumption QTL 240.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)201383430956205956Rat
2317880Alcrsp25Alcohol response QTL 252.3response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)201782709656205956Rat
4889610Pancm3Pancreatic morphology QTL 33.750.001pancreas mass (VT:0010144)pancreas wet weight (CMO:0000626)201887215049108956Rat

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:151
Count of miRNA genes:109
Interacting mature miRNAs:126
Transcripts:ENSRNOT00000000783
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 29 37 27 19 27 1 1 55 24 39 5 1
Low 14 19 13 13 5 8 18 11 2 6 5
Below cutoff 1 1 1 2 2 1 2

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000000783   ⟹   ENSRNOP00000000783
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl2020,576,377 - 20,591,509 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000081113   ⟹   ENSRNOP00000070138
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl2020,577,561 - 20,591,549 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000086806   ⟹   ENSRNOP00000072365
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl2020,576,385 - 20,591,487 (+)Ensembl
RefSeq Acc Id: NM_019296   ⟹   NP_062169
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.22019,266,252 - 19,281,414 (+)NCBI
Rnor_6.02020,576,377 - 20,591,509 (+)NCBI
Rnor_5.02022,694,883 - 22,709,860 (+)NCBI
RGSC_v3.42020,018,044 - 20,044,030 (+)RGD
Celera2020,642,946 - 20,658,475 (+)RGD
Sequence:
RefSeq Acc Id: XM_006256353   ⟹   XP_006256415
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.22019,266,226 - 19,281,417 (+)NCBI
Rnor_6.02020,576,341 - 20,591,510 (+)NCBI
Rnor_5.02022,694,883 - 22,709,860 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_062169 (Get FASTA)   NCBI Sequence Viewer  
  XP_006256415 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH91549 (Get FASTA)   NCBI Sequence Viewer  
  CAA43177 (Get FASTA)   NCBI Sequence Viewer  
  EDL97298 (Get FASTA)   NCBI Sequence Viewer  
  P39951 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_062169   ⟸   NM_019296
- UniProtKB: P39951 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006256415   ⟸   XM_006256353
- Peptide Label: isoform X1
- UniProtKB: P39951 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSRNOP00000000783   ⟸   ENSRNOT00000000783
RefSeq Acc Id: ENSRNOP00000070138   ⟸   ENSRNOT00000081113
RefSeq Acc Id: ENSRNOP00000072365   ⟸   ENSRNOT00000086806
Protein Domains
Protein kinase

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13701557
Promoter ID:EPDNEW_R12081
Type:multiple initiation site
Name:Cdk1_1
Description:cyclin-dependent kinase 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.02020,576,376 - 20,576,436EPDNEW

Strain Variation

Strain Sequence Variants (Rnor 6.0)
ACI/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
ACI/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
ACI/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
BBDP/Wor (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
BN/SsN (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Buf/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
COP/CrCrl (MCW & UW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
University of Wisconsin (Dr. James Shull)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Charles River Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)
F344/NCrl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
F344/NRrrc (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
FHH/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHH/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
FHL/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHL/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
GH/OmrMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
GK/Ox (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LE/Stm (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/Crl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/NCrlBR (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LH/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LL/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LN/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
M520/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
MHS/Gib (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MNS/Gib (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MR/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
SBH/Ygl (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBH/Ygl sequenced by MCW
SBH/Ygl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SBN/Ygl (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBN/Ygl sequenced by MCW
SBN/Ygl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHR/NHsd (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHRSP/Gcrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SR/JrHsd (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Harlan Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SR/JrHsd (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/Jr (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/JrHsdMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SS/JrHsdMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WAG/Rij (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/Gcrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
WKY/NCrl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/NHsd (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WN/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Damaging Variants


Assembly: Rnor_6.0

Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Strain
20 20582870 20582871 G A snv MR/N (MCW), WN/N (MCW)
20 20586555 20586556 G A snv M520/N (MCW), WN/N (MCW)
20 20588970 20588971 T C snv WKY/N (MCW)


Assembly: RGSC_v3.4

Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Strain
20 20024537 20024538 G A snv SHRSP/Gcrc (MDC), MR/N (KNAW), WN/N (KNAW), LE/Stm (KNAW), BN/NHsdMcwi (KNAW)
20 20028222 20028223 G A snv SS/JrHsdMcwi (MCW), M520/N (KNAW), BN/NHsdMcwi (KNAW), ACI/EurMcwi (MCW), HCR/2Mco (UMich), WN/N (KNAW), COP/CrCrl (MCW & UW), LE/Stm (KNAW), FHH/EurMcwi (MCW), FHL/EurMcwi (MCW), LCR/1Mco (UMich)
20 20028302 20028303 G T snv SS/JrHsdMcwi (MCW)
20 20030642 20030643 T C snv WKY/N (KNAW)


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2319 AgrOrtholog
Ensembl Genes ENSRNOG00000000632 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSRNOP00000000783 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOP00000070138 UniProtKB/Swiss-Prot
  ENSRNOP00000072365 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000000783 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOT00000081113 UniProtKB/Swiss-Prot
  ENSRNOT00000086806 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7388690 IMAGE-MGC_LOAD
InterPro Kinase-like_dom_sf UniProtKB/Swiss-Prot
  Prot_kinase_dom UniProtKB/Swiss-Prot
  Protein_kinase_ATP_BS UniProtKB/Swiss-Prot
  Ser/Thr_kinase_AS UniProtKB/Swiss-Prot
KEGG Report rno:54237 UniProtKB/Swiss-Prot
MGC_CLONE MGC:112617 IMAGE-MGC_LOAD
NCBI Gene 54237 ENTREZGENE
Pfam Pkinase UniProtKB/Swiss-Prot
PharmGKB CDC2 RGD
PhenoGen Cdk1 PhenoGen
PROSITE PROTEIN_KINASE_ATP UniProtKB/Swiss-Prot
  PROTEIN_KINASE_DOM UniProtKB/Swiss-Prot
  PROTEIN_KINASE_ST UniProtKB/Swiss-Prot
SMART S_TKc UniProtKB/Swiss-Prot
Superfamily-SCOP SSF56112 UniProtKB/Swiss-Prot
TIGR TC217501
UniProt CDK1_RAT UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary Q5BJB4 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2010-07-02 Cdk1  cyclin-dependent kinase 1  Cdc2  cell division cycle 2, G1 to S and G2 to M  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-09-26 Cdc2  cell division cycle 2, G1 to S and G2 to M  Cdc2a  cell division cycle 2 homolog A (S. pombe)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-11-06 Cdc2a  cell division cycle 2 homolog A (S. pombe)    Cell division cycle control protein 2  Name updated 625702 APPROVED
2002-06-10 Cdc2a  Cell division cycle control protein 2      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_process involved in cell cycle 1298746