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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2319
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cdk1
Name: cyclin-dependent kinase 1
Acc ID: CHEBI:27881
Term: resveratrol
Definition: A stilbenol that is stilbene in which the phenyl groups are substituted at positions 3, 5, and 4' by hydroxy groups.
Chemical ID: MESH:C059514
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cdk1affects phosphorylationEXP 6480464CTDresveratrol affects the phosphorylation of CDK1 proteinPMID:15134381
Cdk1affects expressionISOCDK1 (Homo sapiens)6480464CTDresveratrol affects the expression of CDK1 proteinPMID:12392819
Cdk1decreases expressionISOCDK1 (Homo sapiens)6480464CTDresveratrol results in decreased expression of CDK1 mRNA; resveratrol results in decreased expression of CDK1 proteinPMID:15767336 PMID:17050787 PMID:18089832 PMID:23137833
Cdk1increases expressionISOCDK1 (Homo sapiens)6480464CTDresveratrol results in increased expression of CDK1 mRNA; resveratrol results in increased expression of CDK1 proteinPMID:11577002 PMID:19167446
Cdk1increases phosphorylationISOCDK1 (Homo sapiens)6480464CTDresveratrol results in increased phosphorylation of CDK1 proteinPMID:15975956 PMID:23522185
Cdk1multiple interactionsISOCDK1 (Homo sapiens)6480464CTD[Coumestrol co-treated with resveratrol] results in increased expression of CDK1 mRNA; [temozolomide co-treated with resveratrol] results in decreased phosphorylation of CDK1 protein; Caffeine inhibits the reaction [resveratrol results in increased phosphorylation of CDK1 protein]; resveratrol affects the activity of [CCNB1 protein co-treated with CDK1 protein]; resveratrol results in decreased activity of [CCNB1 protein binds to CDK1 protein]PMID:12392819 PMID:15975956 PMID:17050787 PMID:19167446 PMID:23522185
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