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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2319
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cdk1
Name: cyclin-dependent kinase 1
Acc ID: CHEBI:50131
Term: 5-aza-2'-deoxycytidine
Definition: A 2'-deoxyribonucleoside that has formula C8H12N4O4.
Chemical ID: MESH:C014347
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cdk1multiple interactionsEXP 6480464CTD[Decitabine co-treated with Hydroxamic Acids analog] results in decreased expression of CDK1PMID:21445578
Cdk1increases expressionISOCdk1 (Mus musculus)6480464CTDDecitabine results in increased expression of CDK1 mRNAPMID:27915011
Cdk1increases phosphorylationISOCDK1 (Homo sapiens)6480464CTDDecitabine results in increased phosphorylation of CDK1 proteinPMID:19372550
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