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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2319
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cdk1
Name: cyclin-dependent kinase 1
Acc ID: CHEBI:27899
Term: cisplatin
Definition: A diamminedichloroplatinum compound in which the two ammine ligands and two chloro ligands are oriented in a cis planar configuration around the central platinum ion. An anticancer drug that interacts with, and forms cross-links between, DNA and proteins, it is used as a neoplasm inhibitor to treat solid tumours, primarily of the testis and ovary. Commonly but incorrectly described as an alkylating agent due to its mechanism of action (but it lacks alkyl groups).
Chemical ID: MESH:D002945
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cdk1affects phosphorylationISOCDK1 (Homo sapiens)6480464CTDCisplatin affects the phosphorylation of CDK1 proteinPMID:32562082
Cdk1decreases expressionISOCDK1 (Homo sapiens)6480464CTDCisplatin results in decreased expression of CDK1 mRNAPMID:21603599
Cdk1decreases response to substanceISOCDK1 (Homo sapiens)6480464CTDCDK1 results in decreased susceptibility to CisplatinPMID:21849418
Cdk1increases expressionISOCdk1 (Mus musculus)6480464CTDCisplatin results in increased expression of CDK1 proteinPMID:9098629
Cdk1increases phosphorylationISOCDK1 (Homo sapiens)6480464CTDCisplatin results in increased phosphorylation of CDK1 proteinPMID:20195699 PMID:21592546
Cdk1multiple interactionsISOCDK1 (Homo sapiens)6480464CTD(1,2-bis(1,2-benzisoselenazolone-3(2H)-ketone))ethane inhibits the reaction [Cisplatin results in increased phosphorylation of CDK1 protein]; acetyl-11-ketoboswellic acid affects the reaction [Cisplatin affects the phosphorylation of CDK1 protein]; CDKN1A protein affects the reaction [Cisplatin affects the phosphorylation of CDK1 protein]; Cisplatin affects the reaction [Piroxicam results in decreased expression of CDK1 mRNA]; Cisplatin results in decreased activity of [CCNB1 protein binds to CDK1 protein]PMID:20195699 PMID:21592546 PMID:21858171 PMID:32562082
Cdk1multiple interactionsISOCdk1 (Mus musculus)6480464CTDCaffeine inhibits the reaction [Cisplatin results in increased expression of CDK1 protein]PMID:9098629
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