Cdk1 (cyclin dependent kinase 1) - Rat Genome Database

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Gene: Cdk1 (cyclin dependent kinase 1) Heterocephalus glaber
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Symbol: Cdk1
Name: cyclin dependent kinase 1
RGD ID: 18918222
Description: ENCODES a protein that exhibits chromatin binding (ortholog); cyclin binding (ortholog); cyclin-dependent protein kinase activity (ortholog); INVOLVED IN cellular response to hydrogen peroxide (ortholog); chromosome condensation (ortholog); DNA damage response (ortholog); ASSOCIATED WITH Autosomal Dominant Intellectual Developmental Disorder 70 (ortholog); breast cancer (ortholog); cervical cancer (ortholog); FOUND IN centrosome (ortholog); cyclin A2-CDK1 complex (ortholog); cyclin B1-CDK1 complex (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: cyclin-dependent kinase 1
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: HetGla 1.0 - Naked Mole-Rat female 1.0 Assembly
NCBI Annotation Information: Annotation category: partial on reference assembly
Position:
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247912,891,239 - 2,915,001 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
cell division  (IEA)
cellular response to hydrogen peroxide  (ISO)
chromosome condensation  (ISO)
DNA damage response  (ISO)
epithelial cell differentiation  (ISO)
fibroblast proliferation  (ISO)
G2/M transition of mitotic cell cycle  (IEA)
Golgi disassembly  (ISO)
meiotic cell cycle process involved in oocyte maturation  (ISO)
meiotic spindle organization  (ISO)
microtubule cytoskeleton organization involved in mitosis  (ISO)
mitotic cell cycle phase transition  (ISO)
mitotic G2 DNA damage checkpoint signaling  (IEA,ISO)
mitotic nuclear membrane disassembly  (ISO)
negative regulation of apoptotic process  (ISO)
negative regulation of gene expression  (ISO)
peptidyl-serine phosphorylation  (ISO)
peptidyl-threonine phosphorylation  (ISO)
positive regulation of cardiac muscle cell proliferation  (ISO)
positive regulation of DNA replication  (ISO)
positive regulation of G2/M transition of mitotic cell cycle  (ISO)
positive regulation of gene expression  (ISO)
positive regulation of meiotic cell cycle process involved in oocyte maturation  (ISO)
positive regulation of mitochondrial ATP synthesis coupled electron transport  (ISO)
positive regulation of mitotic sister chromatid segregation  (ISO)
positive regulation of protein import into nucleus  (ISO)
positive regulation of protein localization to nucleus  (ISO)
protein localization to kinetochore  (ISO)
protein phosphorylation  (ISO)
protein-containing complex assembly  (ISO)
regulation of attachment of mitotic spindle microtubules to kinetochore  (ISO)
regulation of circadian rhythm  (ISO)
response to activity  (ISO)
response to amine  (ISO)
response to axon injury  (ISO)
response to cadmium ion  (ISO)
response to copper ion  (ISO)
response to ethanol  (ISO)
response to hydrogen peroxide  (ISO)
response to toxic substance  (ISO)
ventricular cardiac muscle cell development  (ISO)

Cellular Component

References
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Cdk1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247912,891,239 - 2,915,001 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2
CDK1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381060,778,331 - 60,794,852 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1060,778,331 - 60,794,852 (+)EnsemblGRCh38hg38GRCh38
GRCh371062,538,089 - 62,554,610 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361062,205,690 - 62,223,930 (+)NCBINCBI36Build 36hg18NCBI36
Build 341062,209,916 - 62,223,930NCBI
Celera1055,803,740 - 55,820,255 (+)NCBICelera
Cytogenetic Map10q21.2NCBI
HuRef1056,527,463 - 56,544,301 (+)NCBIHuRef
CHM1_11062,820,315 - 62,836,829 (+)NCBICHM1_1
T2T-CHM13v2.01061,635,069 - 61,651,590 (+)NCBIT2T-CHM13v2.0
Cdk1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391069,170,976 - 69,188,742 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1069,170,976 - 69,188,768 (-)EnsemblGRCm39 Ensembl
GRCm381069,335,146 - 69,352,912 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1069,335,146 - 69,352,938 (-)EnsemblGRCm38mm10GRCm38
MGSCv371068,799,383 - 68,815,660 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361068,731,992 - 68,748,269 (-)NCBIMGSCv36mm8
Celera1070,426,785 - 70,443,097 (-)NCBICelera
Cytogenetic Map10B5.3NCBI
cM Map1036.07NCBI
Cdk1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82019,265,252 - 19,280,456 (+)NCBIGRCr8
mRatBN7.22019,266,226 - 19,281,417 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2019,266,248 - 19,281,408 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2019,995,212 - 20,010,375 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02019,347,690 - 19,362,853 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02019,822,895 - 19,838,058 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02020,576,341 - 20,591,510 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2020,576,377 - 20,591,549 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02022,694,883 - 22,709,860 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42020,018,044 - 20,044,030 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12020,031,843 - 20,057,830 (+)NCBI
Celera2020,642,946 - 20,658,475 (+)NCBICelera
RH 3.4 Map20252.37RGD
Cytogenetic Map20p11NCBI
Cdk1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542514,210,680 - 14,226,474 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495542514,210,681 - 14,226,474 (+)NCBIChiLan1.0ChiLan1.0
CDK1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2872,992,580 - 73,009,108 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11072,997,903 - 73,014,430 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01057,314,692 - 57,331,261 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11059,647,993 - 59,664,434 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1059,647,993 - 59,664,434 (+)Ensemblpanpan1.1panPan2
CDK1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1412,884,106 - 12,899,203 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl412,883,385 - 12,899,197 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha413,089,613 - 13,104,900 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0413,149,444 - 13,169,783 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl413,148,851 - 13,178,179 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1413,127,253 - 13,147,585 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0413,245,048 - 13,265,394 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0413,555,896 - 13,576,243 (+)NCBIUU_Cfam_GSD_1.0
Cdk1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440721368,214,228 - 68,227,370 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366142,300,513 - 2,313,624 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366142,300,682 - 2,313,611 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CDK1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1464,233,987 - 64,372,197 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11464,233,945 - 64,255,290 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21469,262,279 - 69,277,262 (+)NCBISscrofa10.2Sscrofa10.2susScr3
CDK1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1970,475,736 - 70,492,947 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366604831,365,769 - 31,382,908 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0


Expression

RNA-SEQ Expression


Sequence


RefSeq Acc Id: XM_021239150   ⟹   XP_021094809
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046247912,891,239 - 2,915,001 (-)NCBI
RefSeq Acc Id: XM_021239152   ⟹   XP_021094811
Type: CODING
Position:
Naked Mole-Rat AssemblyChrPosition (strand)Source
HetGla 1.0NW_0046247912,891,239 - 2,915,001 (-)NCBI
Protein Sequences
Protein RefSeqs XP_021094809 (Get FASTA)   NCBI Sequence Viewer  
  XP_021094811 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSHGLP00000041475
  ENSHGLP00100002239
GenBank Protein JAO01253 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: XP_021094811   ⟸   XM_021239152
- UniProtKB: A0A0P6JIG6 (UniProtKB/TrEMBL),   G5AZC3 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_021094809   ⟸   XM_021239150
- UniProtKB: A0A0P6JIG6 (UniProtKB/TrEMBL),   G5AZC3 (UniProtKB/TrEMBL)


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSHGLG00000032747 UniProtKB/TrEMBL
  ENSHGLG00100035296 UniProtKB/TrEMBL
Ensembl Transcript ENSHGLT00000072507 UniProtKB/TrEMBL
  ENSHGLT00100002289 UniProtKB/TrEMBL
Gene3D-CATH Transferase(Phosphotransferase) domain 1 UniProtKB/TrEMBL
InterPro CDK UniProtKB/TrEMBL
  Kinase-like_dom_sf UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/TrEMBL
  Ser/Thr_kinase_AS UniProtKB/TrEMBL
NCBI Gene Cdk1 ENTREZGENE
PANTHER CELL DIVISION PROTEIN KINASE UniProtKB/TrEMBL
  CYCLIN-DEPENDENT KINASE 1 UniProtKB/TrEMBL
Pfam Pkinase UniProtKB/TrEMBL
PROSITE PROTEIN_KINASE_ATP UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/TrEMBL
  PROTEIN_KINASE_ST UniProtKB/TrEMBL
SMART S_TKc UniProtKB/TrEMBL
Superfamily-SCOP SSF56112 UniProtKB/TrEMBL
UniProt A0A0P6JIG6 ENTREZGENE, UniProtKB/TrEMBL
  G5AZC3 ENTREZGENE, UniProtKB/TrEMBL