CDK1 (cyclin dependent kinase 1) - Rat Genome Database

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Gene: CDK1 (cyclin dependent kinase 1) Homo sapiens
Analyze
Symbol: CDK1
Name: cyclin dependent kinase 1
RGD ID: 731889
HGNC Page HGNC
Description: Enables cyclin binding activity and protein kinase activity. Involved in several processes, including positive regulation of G2/M transition of mitotic cell cycle; positive regulation of mitochondrial ATP synthesis coupled electron transport; and protein phosphorylation. Located in several cellular components, including microtubule cytoskeleton; midbody; and nucleoplasm. Part of cyclin B1-CDK1 complex and cytoplasm. Colocalizes with mitochondrial matrix. Implicated in breast cancer; cervical cancer; and urinary bladder cancer. Biomarker of breast cancer; gallbladder adenocarcinoma; and transitional cell carcinoma.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: CDC2; CDC28A; cell cycle controller CDC2; cell division control protein 2 homolog; cell division cycle 2 homolog a (s. pombe); cell division cycle 2, G1 to S and G2 to M; cell division protein kinase 1; cyclin-dependent kinase 1; DKFZp686L20222; MGC111195; p34 protein kinase; P34CDC2
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1060,778,331 - 60,794,852 (+)EnsemblGRCh38hg38GRCh38
GRCh381060,778,331 - 60,794,852 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371062,538,089 - 62,554,610 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361062,205,690 - 62,223,930 (+)NCBINCBI36hg18NCBI36
Build 341062,209,916 - 62,223,930NCBI
Celera1055,803,740 - 55,820,255 (+)NCBI
Cytogenetic Map10q21.2NCBI
HuRef1056,527,463 - 56,544,301 (+)NCBIHuRef
CHM1_11062,820,315 - 62,836,829 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-catechin  (ISO)
(+)-pilocarpine  (ISO)
(-)-citrinin  (EXP)
(-)-demecolcine  (EXP)
(1S)-bornane-2,3-dione  (EXP)
(20R)-protopanaxadiol  (EXP)
(R)-mevalonic acid  (ISO)
1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane  (ISO)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (ISO)
1,1-dichloroethene  (ISO)
1,2-dimethylhydrazine  (ISO)
1,3-dinitrobenzene  (ISO)
1-chloro-2,4-dinitrobenzene  (ISO)
1-naphthyl isothiocyanate  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrotoluene  (ISO)
2-acetamidofluorene  (ISO)
2-amino-2-deoxy-D-glucopyranose  (ISO)
2-methoxy-17beta-estradiol  (EXP)
2-methylcholine  (EXP)
2-nitrofluorene  (ISO)
2-trans,6-trans,10-trans-geranylgeranyl diphosphate  (ISO)
3',4',5-trihydroxy-3,7-dimethoxyflavone  (EXP)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3-[(4-anilinophenyl)diazenyl]benzene-1-sulfonic acid  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4-(ethoxymethylene)-2-phenyloxazol-5-one  (ISO)
4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one  (ISO)
4-hydroxyphenyl retinamide  (EXP,ISO)
5-aza-2'-deoxycytidine  (EXP,ISO)
5-azacytidine  (EXP)
5-fluorouracil  (EXP,ISO)
5-formyltetrahydrofolic acid  (EXP)
6-propyl-2-thiouracil  (ISO)
acetamide  (ISO)
aconitine  (EXP,ISO)
acrylamide  (EXP,ISO)
afimoxifene  (EXP)
aflatoxin B1  (EXP,ISO)
aflatoxin M1  (EXP)
alachlor  (ISO)
aldehydo-D-glucosamine  (ISO)
all-trans-retinoic acid  (EXP,ISO)
alpha-hexylcinnamaldehyde  (ISO)
alpha-naphthoflavone  (EXP)
alvocidib  (EXP)
amifostine  (EXP)
ammonium chloride  (ISO)
anthocyanin  (EXP)
anthra[1,9-cd]pyrazol-6(2H)-one  (EXP,ISO)
antimycin A  (EXP)
apigenin  (EXP)
arecoline  (EXP)
aristolochic acid  (ISO)
arsane  (EXP)
arsenic atom  (EXP)
arsenite(3-)  (EXP,ISO)
arsenous acid  (EXP,ISO)
atenolol  (ISO)
atrazine  (ISO)
atropine  (EXP)
auraptene  (EXP)
azathioprine  (EXP)
baicalein  (EXP)
belinostat  (EXP)
benzene  (EXP)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (EXP)
benzo[b]fluoranthene  (ISO)
benzophenone  (ISO)
beta-D-glucosamine  (ISO)
beta-naphthoflavone  (EXP,ISO)
bexarotene  (EXP)
bicalutamide  (EXP)
biphenyl-4-amine  (EXP)
bis(2-chloroethyl) sulfide  (EXP)
bis(2-ethylhexyl) phthalate  (EXP)
bisphenol A  (EXP,ISO)
Bisphenol A glycidylmethacrylate  (EXP)
Bisphenol B  (EXP,ISO)
bortezomib  (EXP)
bryostatin 1  (EXP)
buspirone  (ISO)
buta-1,3-diene  (ISO)
butylated hydroxyanisole  (ISO)
cadmium atom  (EXP,ISO)
cadmium dichloride  (EXP,ISO)
caffeine  (EXP,ISO)
calcitriol  (EXP)
camptothecin  (EXP)
cannabidiol  (EXP)
capsaicin  (ISO)
carbon nanotube  (ISO)
catechol  (ISO)
cefaloridine  (ISO)
chlorambucil  (EXP)
chlorendic acid  (ISO)
chloroprene  (ISO)
choline  (ISO)
chromium atom  (EXP)
chromium(6+)  (ISO)
ciglitazone  (EXP)
ciprofloxacin  (ISO)
cisplatin  (EXP,ISO)
clofibrate  (EXP)
clotrimazole  (EXP)
cobalt dichloride  (EXP)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
copper(II) sulfate  (EXP)
corosolic acid  (ISO)
corticosterone  (ISO)
coumestrol  (EXP)
crocidolite asbestos  (EXP)
CU-O LINKAGE  (EXP)
cucurbitacin I  (EXP)
Cuprizon  (ISO)
curcumin  (EXP,ISO)
cyanocob(III)alamin  (ISO)
cyclosporin A  (EXP)
cytochalasin B  (EXP)
deguelin  (EXP)
deoxynivalenol  (EXP)
dexamethasone  (EXP,ISO)
diallyl disulfide  (EXP)
diallyl trisulfide  (EXP)
diarsenic trioxide  (EXP,ISO)
diazinon  (ISO)
dibenz[a,h]anthracene  (ISO)
dibutyl phthalate  (ISO)
dicrotophos  (EXP)
dieldrin  (ISO)
diepoxybutane  (ISO)
diethylstilbestrol  (ISO)
digitoxin  (EXP)
Diosbulbin B  (EXP,ISO)
dioscin  (EXP)
dioxygen  (EXP,ISO)
diuron  (ISO)
dorsomorphin  (EXP)
doxorubicin  (EXP,ISO)
Echimidine  (EXP)
elemental selenium  (EXP)
ellagic acid  (EXP)
ellipticine  (EXP)
endosulfan  (ISO)
Enterolactone  (EXP)
enzyme inhibitor  (EXP)
erythromycin estolate  (ISO)
ethanol  (ISO)
fenbendazole  (ISO)
fenpyroximate  (EXP)
fipronil  (ISO)
fisetin  (EXP)
flumequine  (ISO)
folic acid  (EXP,ISO)
fulvestrant  (EXP)
furan  (ISO)
gamma-linolenic acid  (EXP)
gamma-tocopherol  (ISO)
gefitinib  (ISO)
genistein  (EXP)
geraniol  (EXP)
gingerol  (EXP)
glycidol  (ISO)
glycine betaine  (ISO)
Goe 6976  (EXP)
gold atom  (EXP)
gold(0)  (EXP)
guggulsterone  (EXP)
GW 4064  (EXP)
harmine  (EXP)
hellebrigenin  (EXP)
hydrogen peroxide  (EXP)
hydroxamic acid  (ISO)
inuviscolide  (EXP)
irinotecan  (EXP,ISO)
isoprenaline  (ISO)
ivermectin  (EXP)
kaempferol  (EXP)
ketamine  (ISO)
L-ascorbic acid  (ISO)
L-methionine  (ISO)
Lasiocarpine  (EXP)
lead diacetate  (ISO)
leflunomide  (EXP,ISO)
leptomycin B  (EXP)
levofloxacin  (ISO)
Licochalcone A  (EXP)
Licochalcone B  (EXP)
limonene  (ISO)
lipopolysaccharide  (EXP)
Longikaurin A  (EXP)
lucanthone  (EXP)
luteolin  (EXP)
LY294002  (EXP)
lycopene  (EXP)
malachite green cation  (ISO)
mangiferin  (EXP)
mechlorethamine  (EXP)
MeIQx  (EXP,ISO)
melatonin  (EXP)
mercury dichloride  (ISO)
metformin  (EXP)
methamphetamine  (ISO)
methapyrilene  (ISO)
methotrexate  (EXP)
methyl salicylate  (ISO)
methylmercury chloride  (ISO)
methylparaben  (EXP)
methylseleninic acid  (EXP)
microcystin-LR  (EXP)
mifepristone  (EXP)
mitomycin C  (ISO)
ML-7  (ISO)
monocrotaline  (EXP)
morin  (EXP)
N-acetyl-L-cysteine  (EXP,ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-methyl-4-phenylpyridinium  (EXP,ISO)
N-methyl-N-nitrosourea  (EXP,ISO)
N-nitrosodiethylamine  (ISO)
N-nitrosodimethylamine  (ISO)
N-Nitrosopyrrolidine  (EXP)
naphthalene  (ISO)
nickel atom  (EXP)
nickel subsulfide  (ISO)
nimesulide  (ISO)
nitroprusside  (EXP)
nocodazole  (EXP)
nonanoic acid  (ISO)
O-methyleugenol  (ISO)
ochratoxin A  (EXP,ISO)
okadaic acid  (EXP)
olomoucine  (EXP)
omacetaxine mepesuccinate  (EXP)
orlistat  (EXP)
osthole  (EXP)
oxaliplatin  (EXP,ISO)
ozone  (ISO)
paclitaxel  (EXP)
palbociclib  (EXP,ISO)
Panduratin A  (EXP)
paracetamol  (EXP)
paraquat  (ISO)
parathion  (EXP)
PCB138  (ISO)
Pentoxifylline  (EXP)
perfluorononanoic acid  (EXP)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (EXP)
PF-00477736  (EXP)
phenethyl caffeate  (EXP)
phenethyl isothiocyanate  (ISO)
phenformin  (ISO)
phenobarbital  (ISO)
phenytoin  (ISO)
PhIP  (EXP,ISO)
phorbol 13-acetate 12-myristate  (ISO)
phthalaldehyde  (ISO)
phytoestrogen  (EXP)
picoxystrobin  (EXP)
picropodophyllotoxin  (EXP)
piperine  (ISO)
piperonyl butoxide  (ISO)
Pirarubicin  (EXP)
pirinixic acid  (ISO)
piroxicam  (EXP)
poly(propylene imine) macromolecule  (EXP)
potassium bromate  (EXP)
potassium dichromate  (ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
procyanidin  (EXP)
progesterone  (EXP,ISO)
propanal  (EXP)
propiconazole  (ISO)
propofol  (EXP)
pyrimidifen  (EXP)
quercetin  (EXP,ISO)
quinolines  (EXP)
reactive oxygen species  (EXP)
resveratrol  (EXP,ISO)
riddelliine  (EXP)
rotenone  (EXP,ISO)
saccharin  (ISO)
SB 203580  (EXP)
selenium atom  (EXP)
silibinin  (EXP)
silicon dioxide  (EXP,ISO)
silver atom  (EXP)
silver(0)  (EXP)
silver(1+) nitrate  (EXP)
simvastatin  (EXP,ISO)
sirolimus  (EXP,ISO)
sodium arsenite  (EXP,ISO)
sodium dichromate  (ISO)
Soman  (ISO)
sorafenib  (ISO)
SR 144528  (EXP)
sterigmatocystin  (EXP,ISO)
sulfadimethoxine  (ISO)
sulforaphane  (EXP)
sulindac  (EXP)
sunitinib  (EXP)
tamoxifen  (EXP,ISO)
tanespimycin  (EXP)
tebufenpyrad  (EXP)
temozolomide  (EXP)
terameprocol  (EXP)
tert-butyl hydroperoxide  (ISO)
testosterone  (EXP,ISO)
testosterone enanthate  (EXP)
tetrachloromethane  (ISO)
thalidomide  (EXP)
thapsigargin  (EXP)
thifluzamide  (EXP)
thimerosal  (EXP)
thioacetamide  (ISO)
titanium dioxide  (EXP,ISO)
tocopherol  (ISO)
toluene 2,4-diisocyanate  (ISO)
Tomentosin  (EXP)
topotecan  (ISO)
trabectedin  (ISO)
triazoles  (EXP)
Tributyltin oxide  (ISO)
trichloroethene  (ISO)
trichostatin A  (EXP)
trimellitic anhydride  (ISO)
Triptolide  (EXP,ISO)
triptonide  (ISO)
troglitazone  (EXP)
tropan-3alpha-yl 3-hydroxy-2-phenylpropanoate  (EXP)
trovafloxacin  (ISO)
tungsten  (ISO)
tunicamycin  (EXP)
tyrphostin AG 1478  (EXP)
urethane  (EXP)
vincaleukoblastine  (EXP)
vincristine  (EXP)
vorinostat  (EXP)
wortmannin  (EXP)
Xanthatin  (EXP)
zaragozic acid A  (ISO)
zidovudine  (EXP)
zinc atom  (ISO)
zinc(0)  (ISO)
zoledronic acid  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
animal organ regeneration  (IEA,ISO)
apoptotic process  (IEA)
cell aging  (IEA,ISO)
cell division  (IEA)
cell migration  (TAS)
cell population proliferation  (IEA,ISO)
cellular response to hydrogen peroxide  (IEA,ISO)
centrosome cycle  (TAS)
chromosome condensation  (IEA,ISO)
DNA repair  (TAS)
DNA replication  (TAS)
epithelial cell differentiation  (IEP)
ERK1 and ERK2 cascade  (TAS)
G2/M transition of mitotic cell cycle  (IBA,TAS)
Golgi disassembly  (ISS)
histone phosphorylation  (IEA)
meiotic cell cycle process involved in oocyte maturation  (ISO)
meiotic spindle organization  (ISO)
microtubule cytoskeleton organization  (TAS)
mitotic cell cycle  (ISO)
mitotic cell cycle phase transition  (ISO)
mitotic G2 DNA damage checkpoint signaling  (IBA,ISO)
negative regulation of apoptotic process  (IDA)
negative regulation of gene expression  (IEA,ISO)
peptidyl-serine phosphorylation  (IDA)
peptidyl-threonine phosphorylation  (IDA,IMP)
positive regulation of cardiac muscle cell proliferation  (IEA,ISO)
positive regulation of DNA replication  (IEA,ISO)
positive regulation of G2/M transition of mitotic cell cycle  (IMP)
positive regulation of gene expression  (IEA,ISO)
positive regulation of meiotic cell cycle process involved in oocyte maturation  (ISO)
positive regulation of mitochondrial ATP synthesis coupled electron transport  (IMP)
positive regulation of mitotic cell cycle  (ISO)
positive regulation of protein import into nucleus  (IEA,ISO)
positive regulation of protein localization to nucleus  (IMP)
pronuclear fusion  (TAS)
protein deubiquitination  (TAS)
protein localization to kinetochore  (IDA)
protein phosphorylation  (IBA,IDA,IEA,IMP,ISO)
protein-containing complex assembly  (IEA,ISO)
regulation of circadian rhythm  (IMP)
regulation of embryonic development  (TAS)
regulation of Schwann cell differentiation  (TAS)
response to activity  (IEA,ISO)
response to amine  (IEA,ISO)
response to axon injury  (IEA,ISO)
response to cadmium ion  (IEA,ISO)
response to copper ion  (IEA,ISO)
response to ethanol  (IEA,ISO)
response to hydrogen peroxide  (ISO)
response to organic cyclic compound  (IEA,ISO)
response to organonitrogen compound  (ISO)
response to toxic substance  (IEA,ISO)
response to xenobiotic stimulus  (IEA,ISO)
rhythmic process  (IEA)
ventricular cardiac muscle cell development  (IEA,ISO)
viral entry into host cell  (IEA)

References

Additional References at PubMed
PMID:914146   PMID:1310466   PMID:1312467   PMID:1318195   PMID:1323485   PMID:1384126   PMID:1388288   PMID:1400350   PMID:1406653   PMID:1425574   PMID:1628647   PMID:1717476  
PMID:1748630   PMID:1756735   PMID:1828290   PMID:1916766   PMID:1939057   PMID:2013279   PMID:2183353   PMID:2227411   PMID:2344612   PMID:2473839   PMID:2538242   PMID:2541912  
PMID:2570636   PMID:2686978   PMID:3289755   PMID:3553962   PMID:7474080   PMID:7474100   PMID:7494303   PMID:7499230   PMID:7578274   PMID:7588608   PMID:7590285   PMID:7592773  
PMID:7635160   PMID:7666531   PMID:7673335   PMID:7716549   PMID:7724583   PMID:7737117   PMID:7739547   PMID:7769006   PMID:7790358   PMID:7799941   PMID:7815540   PMID:7822264  
PMID:7876309   PMID:7902715   PMID:7903056   PMID:7925482   PMID:7944411   PMID:7949095   PMID:7969176   PMID:7983050   PMID:8034666   PMID:8051108   PMID:8051175   PMID:8070405  
PMID:8084605   PMID:8087847   PMID:8119945   PMID:8125092   PMID:8127873   PMID:8242750   PMID:8325880   PMID:8376365   PMID:8397206   PMID:8397207   PMID:8404858   PMID:8423786  
PMID:8428596   PMID:8440392   PMID:8463339   PMID:8475101   PMID:8491187   PMID:8524869   PMID:8548803   PMID:8565853   PMID:8626512   PMID:8626527   PMID:8631817   PMID:8652557  
PMID:8662825   PMID:8663071   PMID:8672508   PMID:8806671   PMID:8910336   PMID:9001210   PMID:9053846   PMID:9069267   PMID:9094673   PMID:9109675   PMID:9126608   PMID:9130708  
PMID:9141461   PMID:9188632   PMID:9199321   PMID:9235942   PMID:9242535   PMID:9244350   PMID:9247342   PMID:9258347   PMID:9268380   PMID:9271440   PMID:9295339   PMID:9315091  
PMID:9315635   PMID:9398320   PMID:9467949   PMID:9467962   PMID:9515786   PMID:9520381   PMID:9524113   PMID:9525956   PMID:9560267   PMID:9575153   PMID:9585407   PMID:9600099  
PMID:9614189   PMID:9668078   PMID:9725910   PMID:9733650   PMID:9753325   PMID:9774639   PMID:9885575   PMID:9891079   PMID:9926943   PMID:9988268   PMID:9990288   PMID:10077596  
PMID:10339564   PMID:10359664   PMID:10362260   PMID:10373560   PMID:10383391   PMID:10395539   PMID:10403367   PMID:10497277   PMID:10502411   PMID:10504341   PMID:10524633   PMID:10564259  
PMID:10602502   PMID:10636877   PMID:10656688   PMID:10712923   PMID:10716937   PMID:10737800   PMID:10747892   PMID:10764745   PMID:10766737   PMID:10767298   PMID:10769027   PMID:10793135  
PMID:10799291   PMID:10825186   PMID:10864927   PMID:10884347   PMID:10896934   PMID:10924145   PMID:10938080   PMID:10958988   PMID:10973963   PMID:11034995   PMID:11069302   PMID:11076863  
PMID:11076968   PMID:11113134   PMID:11113184   PMID:11135364   PMID:11136719   PMID:11259605   PMID:11278541   PMID:11278991   PMID:11285280   PMID:11298763   PMID:11306463   PMID:11310559  
PMID:11326318   PMID:11327730   PMID:11331587   PMID:11395479   PMID:11444800   PMID:11470801   PMID:11504921   PMID:11516829   PMID:11520933   PMID:11531413   PMID:11549262   PMID:11559705  
PMID:11574543   PMID:11584018   PMID:11598127   PMID:11683421   PMID:11687586   PMID:11774038   PMID:11779217   PMID:11782384   PMID:11836499   PMID:11861764   PMID:11878934   PMID:11895447  
PMID:11901153   PMID:11953320   PMID:11980914   PMID:11986303   PMID:12058066   PMID:12077309   PMID:12107172   PMID:12124778   PMID:12145207   PMID:12151413   PMID:12177195   PMID:12186947  
PMID:12190313   PMID:12200623   PMID:12221128   PMID:12361598   PMID:12372621   PMID:12397081   PMID:12407107   PMID:12411508   PMID:12450396   PMID:12468530   PMID:12477932   PMID:12525641  
PMID:12551973   PMID:12556484   PMID:12569090   PMID:12569365   PMID:12586835   PMID:12604359   PMID:12612056   PMID:12612082   PMID:12613668   PMID:12648761   PMID:12676926   PMID:12721286  
PMID:12742823   PMID:12771130   PMID:12775724   PMID:12791267   PMID:12810701   PMID:12832492   PMID:12839990   PMID:12852856   PMID:12853968   PMID:12881709   PMID:12884029   PMID:12912980  
PMID:12920125   PMID:14499622   PMID:14551205   PMID:14635192   PMID:14645578   PMID:14654553   PMID:14697231   PMID:14699166   PMID:14993212   PMID:15014043   PMID:15016823   PMID:15024056  
PMID:15030318   PMID:15050687   PMID:15070733   PMID:15073847   PMID:15082718   PMID:15125835   PMID:15142377   PMID:15145941   PMID:15147269   PMID:15148369   PMID:15175024   PMID:15181148  
PMID:15215233   PMID:15265780   PMID:15276183   PMID:15311285   PMID:15317660   PMID:15345747   PMID:15367677   PMID:15368451   PMID:15474478   PMID:15489334   PMID:15489336   PMID:15525513  
PMID:15525677   PMID:15531913   PMID:15541388   PMID:15578977   PMID:15582998   PMID:15591787   PMID:15592455   PMID:15604258   PMID:15635413   PMID:15657067   PMID:15662526   PMID:15665273  
PMID:15674323   PMID:15678101   PMID:15725353   PMID:15735702   PMID:15735705   PMID:15767402   PMID:15780175   PMID:15782160   PMID:15790566   PMID:15800651   PMID:15817944   PMID:15888452  
PMID:15951569   PMID:15989971   PMID:16009130   PMID:16036217   PMID:16109376   PMID:16118207   PMID:16142332   PMID:16159883   PMID:16192727   PMID:16198290   PMID:16205633   PMID:16226712  
PMID:16237118   PMID:16247472   PMID:16258277   PMID:16344560   PMID:16354571   PMID:16371510   PMID:16377132   PMID:16381901   PMID:16385451   PMID:16407259   PMID:16427064   PMID:16458891  
PMID:16462731   PMID:16465393   PMID:16474839   PMID:16478538   PMID:16519687   PMID:16533053   PMID:16565220   PMID:16629900   PMID:16682949   PMID:16760428   PMID:16772293   PMID:16784539  
PMID:16807237   PMID:16880735   PMID:16880739   PMID:16888198   PMID:16998479   PMID:17011204   PMID:17012222   PMID:17013563   PMID:17043241   PMID:17098733   PMID:17159347   PMID:17171635  
PMID:17172867   PMID:17192257   PMID:17200138   PMID:17242184   PMID:17274640   PMID:17283331   PMID:17327911   PMID:17349584   PMID:17351640   PMID:17359356   PMID:17373700   PMID:17386261  
PMID:17419986   PMID:17431037   PMID:17433108   PMID:17466630   PMID:17472438   PMID:17474786   PMID:17488622   PMID:17488717   PMID:17498878   PMID:17525531   PMID:17525741   PMID:17540176  
PMID:17586317   PMID:17636382   PMID:17679094   PMID:17681274   PMID:17725712   PMID:17906618   PMID:17960875   PMID:18003885   PMID:18025303   PMID:18029348   PMID:18056802   PMID:18069625  
PMID:18195732   PMID:18201571   PMID:18230152   PMID:18245089   PMID:18247328   PMID:18271526   PMID:18272572   PMID:18272575   PMID:18329369   PMID:18337751   PMID:18347064   PMID:18356527  
PMID:18372919   PMID:18408765   PMID:18434602   PMID:18445273   PMID:18450493   PMID:18457437   PMID:18471975   PMID:18477460   PMID:18480403   PMID:18490441   PMID:18514189   PMID:18550795  
PMID:18560763   PMID:18568422   PMID:18593881   PMID:18615582   PMID:18635963   PMID:18695677   PMID:18799590   PMID:18942077   PMID:18950845   PMID:19048596   PMID:19056867   PMID:19061641  
PMID:19066288   PMID:19107194   PMID:19134343   PMID:19135898   PMID:19158392   PMID:19162005   PMID:19223178   PMID:19275580   PMID:19275583   PMID:19275586   PMID:19275588   PMID:19303298  
PMID:19344781   PMID:19364923   PMID:19369249   PMID:19375851   PMID:19454010   PMID:19458171   PMID:19473963   PMID:19483727   PMID:19509060   PMID:19540122   PMID:19615732   PMID:19664338  
PMID:19683496   PMID:19687009   PMID:19723060   PMID:19725879   PMID:19737929   PMID:19738201   PMID:19786724   PMID:19789190   PMID:19815027   PMID:19837665   PMID:19879842   PMID:19884882  
PMID:19917720   PMID:19946888   PMID:20062077   PMID:20068230   PMID:20068231   PMID:20126263   PMID:20169205   PMID:20171170   PMID:20181698   PMID:20228808   PMID:20360007   PMID:20360068  
PMID:20367638   PMID:20368335   PMID:20368358   PMID:20379221   PMID:20395957   PMID:20404109   PMID:20412769   PMID:20439461   PMID:20444701   PMID:20467437   PMID:20508983   PMID:20526282  
PMID:20581839   PMID:20679368   PMID:20711190   PMID:20733055   PMID:20739936   PMID:20808790   PMID:20810654   PMID:20890132   PMID:20935635   PMID:20937773   PMID:20956543   PMID:20974803  
PMID:20974812   PMID:21041660   PMID:21059642   PMID:21081492   PMID:21081666   PMID:21120602   PMID:21123648   PMID:21131960   PMID:21135039   PMID:21148318   PMID:21262764   PMID:21308745  
PMID:21319273   PMID:21325631   PMID:21379580   PMID:21406398   PMID:21454540   PMID:21488187   PMID:21489275   PMID:21492153   PMID:21498573   PMID:21504622   PMID:21522128   PMID:21525341  
PMID:21535261   PMID:21569376   PMID:21654808   PMID:21655336   PMID:21659531   PMID:21712819   PMID:21743465   PMID:21767532   PMID:21813648   PMID:21840486   PMID:21871177   PMID:21871181  
PMID:21873635   PMID:21875946   PMID:21878504   PMID:21878640   PMID:21887332   PMID:21900237   PMID:21900495   PMID:21907836   PMID:21918813   PMID:21924351   PMID:21925791   PMID:21951856  
PMID:21952639   PMID:21987589   PMID:21988832   PMID:21998300   PMID:22024133   PMID:22071694   PMID:22101338   PMID:22137483   PMID:22158041   PMID:22163316   PMID:22266860   PMID:22268729  
PMID:22407595   PMID:22482362   PMID:22496227   PMID:22539978   PMID:22552942   PMID:22580043   PMID:22617334   PMID:22623428   PMID:22689984   PMID:22718829   PMID:22726437   PMID:22768111  
PMID:22784093   PMID:22814604   PMID:22848730   PMID:22854038   PMID:22863883   PMID:22871736   PMID:22907750   PMID:22939629   PMID:22949227   PMID:22962268   PMID:22965228   PMID:23045552  
PMID:23125841   PMID:23202514   PMID:23264621   PMID:23330000   PMID:23355470   PMID:23383273   PMID:23403292   PMID:23430691   PMID:23455152   PMID:23471882   PMID:23509069   PMID:23518499  
PMID:23525902   PMID:23532886   PMID:23543736   PMID:23574715   PMID:23601106   PMID:23602568   PMID:23619525   PMID:23667531   PMID:23720738   PMID:23729730   PMID:23738518   PMID:23775624  
PMID:23776131   PMID:23799914   PMID:23813879   PMID:23814058   PMID:23824909   PMID:23901111   PMID:23908594   PMID:23921553   PMID:23933584   PMID:23956138   PMID:23958962   PMID:23966160  
PMID:23990466   PMID:24013421   PMID:24101154   PMID:24137814   PMID:24158819   PMID:24189531   PMID:24218572   PMID:24248602   PMID:24302728   PMID:24327015   PMID:24358021   PMID:24362465  
PMID:24378347   PMID:24386390   PMID:24386425   PMID:24444383   PMID:24447338   PMID:24457600   PMID:24464679   PMID:24484936   PMID:24508230   PMID:24530506   PMID:24583019   PMID:24613305  
PMID:24623419   PMID:24626186   PMID:24656812   PMID:24658140   PMID:24675888   PMID:24677263   PMID:24705021   PMID:24711643   PMID:24744753   PMID:24746669   PMID:24799281   PMID:24859236  
PMID:24981860   PMID:25013792   PMID:25032860   PMID:25036637   PMID:25048371   PMID:25071185   PMID:25113031   PMID:25120812   PMID:25147182   PMID:25149538   PMID:25218592   PMID:25218637  
PMID:25246615   PMID:25315684   PMID:25375373   PMID:25398907   PMID:25402006   PMID:25411249   PMID:25416956   PMID:25433945   PMID:25443276   PMID:25483092   PMID:25511643   PMID:25520504  
PMID:25533340   PMID:25541464   PMID:25545367   PMID:25603287   PMID:25607646   PMID:25621953   PMID:25625243   PMID:25643699   PMID:25659430   PMID:25670854   PMID:25691442   PMID:25693804  
PMID:25750436   PMID:25753036   PMID:25786624   PMID:25800736   PMID:25819031   PMID:25849598   PMID:25852190   PMID:25864384   PMID:25883264   PMID:25885523   PMID:25910705   PMID:25921289  
PMID:25947085   PMID:25959826   PMID:25963737   PMID:25981880   PMID:26002580   PMID:26029996   PMID:26078008   PMID:26141949   PMID:26177583   PMID:26186194   PMID:26259146   PMID:26323689  
PMID:26344197   PMID:26391950   PMID:26442525   PMID:26483157   PMID:26496610   PMID:26506418   PMID:26549023   PMID:26549230   PMID:26603838   PMID:26647806   PMID:26648125   PMID:26663909  
PMID:26670043   PMID:26674342   PMID:26674376   PMID:26687548   PMID:26709398   PMID:26777405   PMID:26808496   PMID:26881434   PMID:26912061   PMID:26912231   PMID:26942677   PMID:26972000  
PMID:27025967   PMID:27030108   PMID:27030811   PMID:27068477   PMID:27105124   PMID:27109354   PMID:27112295   PMID:27134283   PMID:27185864   PMID:27196765   PMID:27203179   PMID:27207654  
PMID:27226586   PMID:27238018   PMID:27281342   PMID:27320910   PMID:27383761   PMID:27384476   PMID:27385216   PMID:27402161   PMID:27402756   PMID:27462423   PMID:27485598   PMID:27486754  
PMID:27520372   PMID:27535497   PMID:27542221   PMID:27565725   PMID:27566175   PMID:27609421   PMID:27626412   PMID:27634057   PMID:27663664   PMID:27669826   PMID:27684411   PMID:27716745  
PMID:27726420   PMID:27773672   PMID:27831827   PMID:27831832   PMID:27835911   PMID:27880917   PMID:27926873   PMID:27927753   PMID:28030798   PMID:28059702   PMID:28191891   PMID:28345297  
PMID:28377371   PMID:28378594   PMID:28381168   PMID:28434945   PMID:28514442   PMID:28515276   PMID:28534969   PMID:28561026   PMID:28588300   PMID:28598010   PMID:28675297   PMID:28678347  
PMID:28700943   PMID:28739871   PMID:28740209   PMID:28780319   PMID:28855742   PMID:28869606   PMID:28899430   PMID:28946554   PMID:29044420   PMID:29084722   PMID:29117863   PMID:29128334  
PMID:29154753   PMID:29180619   PMID:29229926   PMID:29263404   PMID:29298432   PMID:29331416   PMID:29424068   PMID:29467282   PMID:29608985   PMID:29676528   PMID:29764937   PMID:29777862  
PMID:29778605   PMID:29789527   PMID:29802200   PMID:29843367   PMID:29844126   PMID:29845934   PMID:29884807   PMID:29898406   PMID:29911972   PMID:29930204   PMID:29930206   PMID:29955894  
PMID:30008317   PMID:30033366   PMID:30045664   PMID:30068654   PMID:30086426   PMID:30089874   PMID:30135207   PMID:30217955   PMID:30220558   PMID:30272324   PMID:30297536   PMID:30425250  
PMID:30442662   PMID:30463901   PMID:30476929   PMID:30481564   PMID:30538118   PMID:30576375   PMID:30619736   PMID:30644102   PMID:30664711   PMID:30669930   PMID:30674582   PMID:30718768  
PMID:30723163   PMID:30726872   PMID:30765437   PMID:30765611   PMID:30816115   PMID:30833792   PMID:30898709   PMID:30927017   PMID:30948266   PMID:30974121   PMID:30995489   PMID:31067491  
PMID:31091453   PMID:31160578   PMID:31176784   PMID:31239290   PMID:31270457   PMID:31299612   PMID:31347720   PMID:31378894   PMID:31420536   PMID:31437213   PMID:31469407   PMID:31470122  
PMID:31494926   PMID:31519809   PMID:31531359   PMID:31540324   PMID:31571090   PMID:31586073   PMID:31602636   PMID:31676716   PMID:31709755   PMID:31732153   PMID:31733992   PMID:31746435  
PMID:31822694   PMID:31852787   PMID:31858592   PMID:31870357   PMID:31875843   PMID:31980649   PMID:32020821   PMID:32040547   PMID:32120135   PMID:32129710   PMID:32152128   PMID:32236513  
PMID:32275316   PMID:32416067   PMID:32460013   PMID:32511789   PMID:32516310   PMID:32529326   PMID:32612115   PMID:32711345   PMID:32759885   PMID:32780723   PMID:32802196   PMID:32807901  
PMID:32811807   PMID:32814053   PMID:32814769   PMID:32863381   PMID:32867711   PMID:32900880   PMID:32961751   PMID:33037310   PMID:33197745   PMID:33248027   PMID:33290118   PMID:33306668  
PMID:33556637   PMID:33567341   PMID:33608020   PMID:33629305   PMID:33676182   PMID:33685293   PMID:33727226   PMID:33742100   PMID:33896262   PMID:33961781   PMID:34023852   PMID:34064109  
PMID:34067359   PMID:34079125   PMID:34080795   PMID:34089703   PMID:34118235   PMID:34286694   PMID:34290405   PMID:34362492   PMID:34397869  


Genomics

Comparative Map Data
CDK1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1060,778,331 - 60,794,852 (+)EnsemblGRCh38hg38GRCh38
GRCh381060,778,331 - 60,794,852 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371062,538,089 - 62,554,610 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361062,205,690 - 62,223,930 (+)NCBINCBI36hg18NCBI36
Build 341062,209,916 - 62,223,930NCBI
Celera1055,803,740 - 55,820,255 (+)NCBI
Cytogenetic Map10q21.2NCBI
HuRef1056,527,463 - 56,544,301 (+)NCBIHuRef
CHM1_11062,820,315 - 62,836,829 (+)NCBICHM1_1
Cdk1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391069,170,976 - 69,188,742 (-)NCBIGRCm39mm39
GRCm39 Ensembl1069,170,976 - 69,188,768 (-)Ensembl
GRCm381069,335,146 - 69,352,912 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1069,335,146 - 69,352,938 (-)EnsemblGRCm38mm10GRCm38
MGSCv371068,799,383 - 68,815,660 (-)NCBIGRCm37mm9NCBIm37
MGSCv361068,731,992 - 68,748,269 (-)NCBImm8
Celera1070,426,785 - 70,443,097 (-)NCBICelera
Cytogenetic Map10B5.3NCBI
cM Map1036.07NCBI
Cdk1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.22019,266,226 - 19,281,417 (+)NCBImRatBN7.2
mRatBN7.2 Ensembl2019,266,248 - 19,281,408 (+)Ensembl
Rnor_6.02020,576,341 - 20,591,510 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2020,576,377 - 20,591,549 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02022,694,883 - 22,709,860 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42020,018,044 - 20,044,030 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.12020,031,843 - 20,057,830 (+)NCBI
Celera2020,642,946 - 20,658,475 (+)NCBICelera
RH 3.4 Map20252.37RGD
Cytogenetic Map20p11NCBI
Cdk1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542514,210,680 - 14,226,474 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495542514,210,681 - 14,226,474 (+)NCBIChiLan1.0ChiLan1.0
CDK1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11059,647,993 - 59,664,434 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1059,647,993 - 59,664,434 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01057,314,692 - 57,331,261 (+)NCBIMhudiblu_PPA_v0panPan3
CDK1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1412,884,106 - 12,899,203 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl412,883,385 - 12,899,197 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha413,089,613 - 13,104,900 (+)NCBI
ROS_Cfam_1.0413,149,444 - 13,169,783 (+)NCBI
UMICH_Zoey_3.1413,127,253 - 13,147,585 (+)NCBI
UNSW_CanFamBas_1.0413,245,048 - 13,265,394 (+)NCBI
UU_Cfam_GSD_1.0413,555,896 - 13,576,243 (+)NCBI
Cdk1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440721368,214,228 - 68,227,370 (-)NCBI
SpeTri2.0NW_0049366142,300,682 - 2,313,611 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CDK1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1464,233,988 - 64,395,453 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11464,233,945 - 64,255,290 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21469,262,279 - 69,277,262 (+)NCBISscrofa10.2Sscrofa10.2susScr3
CDK1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1970,475,736 - 70,492,947 (-)NCBIChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366604831,365,769 - 31,382,908 (-)NCBIVero_WHO_p1.0
Cdk1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247912,891,239 - 2,915,001 (-)NCBIHetGla_female_1.0hetGla2

Position Markers
SHGC-64950  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371062,545,433 - 62,545,627UniSTSGRCh37
Build 361062,215,439 - 62,215,633RGDNCBI36
Celera1055,811,083 - 55,811,277RGD
Cytogenetic Map10q21.1UniSTS
HuRef1056,534,715 - 56,534,909UniSTS
TNG Radiation Hybrid Map1028513.0UniSTS
RH71273  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371062,551,899 - 62,552,040UniSTSGRCh37
Build 361062,221,905 - 62,222,046RGDNCBI36
Celera1055,817,545 - 55,817,686RGD
Cytogenetic Map10q21.1UniSTS
HuRef1056,541,176 - 56,541,317UniSTS
GeneMap99-GB4 RH Map10354.01UniSTS
SHGC-57924  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371062,554,357 - 62,554,493UniSTSGRCh37
Build 361062,224,363 - 62,224,499RGDNCBI36
Celera1055,820,002 - 55,820,138RGD
Cytogenetic Map10q21.1UniSTS
TNG Radiation Hybrid Map1028523.0UniSTS
RH68267  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371062,538,154 - 62,538,294UniSTSGRCh37
Build 361062,208,160 - 62,208,300RGDNCBI36
Celera1055,803,805 - 55,803,945RGD
Cytogenetic Map10q21.1UniSTS
HuRef1056,527,528 - 56,527,668UniSTS
GeneMap99-GB4 RH Map10354.01UniSTS
NCBI RH Map10726.9UniSTS
ksks369  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371062,551,741 - 62,552,018UniSTSGRCh37
Celera1055,817,387 - 55,817,664UniSTS
HuRef1056,541,019 - 56,541,295UniSTS

miRNA Target Status

Confirmed Target Of
miRNA GeneMature miRNAMethod NameResult TypeData TypeSupport TypePMID
MIR663Ahsa-miR-663aMirtarbaseexternal_infoWestern blot;OtherFunctional MTI20514450
MIR24-2hsa-miR-24-3pMirtarbaseexternal_infoMicroarray//Reporter assay;Western blot;qRT-PCR;MiFunctional MTI19748357
MIR24-1hsa-miR-24-3pMirtarbaseexternal_infoMicroarray//Reporter assay;Western blot;qRT-PCR;MiFunctional MTI19748357
MIR650hsa-miR-650OncomiRDBexternal_infoNANA22234685

Predicted Target Of
Summary Value
Count of predictions:1103
Count of miRNA genes:371
Interacting mature miRNAs:395
Transcripts:ENST00000316629, ENST00000373809, ENST00000395284, ENST00000448257, ENST00000475504, ENST00000487784, ENST00000519078, ENST00000519760
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system visual system adipose tissue appendage entire extraembryonic component pharyngeal arch
High
Medium 390 44 180 117 810 101 566 61 192 104 730 376 29 44 129 4
Low 1694 2193 1320 308 859 173 3131 1131 1725 295 719 1235 136 1156 2000 2 1
Below cutoff 352 743 222 195 277 188 656 1000 1795 20 8 1 9 1 4 656

Sequence

Nucleotide Sequences
RefSeq Transcripts NG_029877 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001170406 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001170407 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001320918 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001786 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_033379 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_005270303 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AA459484 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC022390 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF512554 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK291939 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK295741 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AW976143 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC014563 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC107750 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BF685285 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BG723076 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BQ308742 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BT007004 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BU633268 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471083 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CR933728 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  D32223 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  D88357 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DA823877 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KT584817 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X05360 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X66172 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  Y00272 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENST00000316629   ⟹   ENSP00000325970
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1060,778,454 - 60,794,843 (+)Ensembl
RefSeq Acc Id: ENST00000373809   ⟹   ENSP00000362915
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1060,780,153 - 60,794,852 (+)Ensembl
RefSeq Acc Id: ENST00000395284   ⟹   ENSP00000378699
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1060,778,478 - 60,794,852 (+)Ensembl
RefSeq Acc Id: ENST00000448257   ⟹   ENSP00000397973
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1060,778,493 - 60,794,828 (+)Ensembl
RefSeq Acc Id: ENST00000475504
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1060,778,365 - 60,787,069 (+)Ensembl
RefSeq Acc Id: ENST00000487784
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1060,787,671 - 60,791,927 (+)Ensembl
RefSeq Acc Id: ENST00000519078   ⟹   ENSP00000430665
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1060,778,331 - 60,791,969 (+)Ensembl
RefSeq Acc Id: ENST00000519760
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1060,778,457 - 60,783,593 (+)Ensembl
RefSeq Acc Id: ENST00000614696   ⟹   ENSP00000482996
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1060,778,496 - 60,794,843 (+)Ensembl
RefSeq Acc Id: NM_001170406   ⟹   NP_001163877
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381060,778,331 - 60,787,069 (+)NCBI
GRCh371062,538,089 - 62,554,610 (+)ENTREZGENE
HuRef1056,527,463 - 56,544,301 (+)ENTREZGENE
CHM1_11062,820,315 - 62,829,050 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001170407   ⟹   NP_001163878
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381060,778,478 - 60,787,069 (+)NCBI
GRCh371062,538,089 - 62,554,610 (+)ENTREZGENE
HuRef1056,527,463 - 56,544,301 (+)ENTREZGENE
CHM1_11062,820,438 - 62,829,050 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001320918   ⟹   NP_001307847
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381060,778,331 - 60,794,852 (+)NCBI
CHM1_11062,820,315 - 62,836,829 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001786   ⟹   NP_001777
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381060,778,478 - 60,794,852 (+)NCBI
GRCh371062,538,089 - 62,554,610 (+)ENTREZGENE
Build 361062,205,690 - 62,223,930 (+)NCBI Archive
HuRef1056,527,463 - 56,544,301 (+)ENTREZGENE
CHM1_11062,820,438 - 62,836,829 (+)NCBI
Sequence:
RefSeq Acc Id: NM_033379   ⟹   NP_203698
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381060,778,478 - 60,794,852 (+)NCBI
GRCh371062,538,089 - 62,554,610 (+)ENTREZGENE
Build 361062,209,917 - 62,223,930 (+)NCBI Archive
HuRef1056,527,463 - 56,544,301 (+)ENTREZGENE
CHM1_11062,820,438 - 62,836,829 (+)NCBI
Sequence:
RefSeq Acc Id: XM_005270303   ⟹   XP_005270360
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381060,778,470 - 60,794,852 (+)NCBI
GRCh371062,538,089 - 62,554,610 (+)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_001163877   ⟸   NM_001170406
- Peptide Label: isoform 4
- UniProtKB: B7Z3D6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001777   ⟸   NM_001786
- Peptide Label: isoform 1
- UniProtKB: P06493 (UniProtKB/Swiss-Prot),   I6L9I5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_203698   ⟸   NM_033379
- Peptide Label: isoform 2
- UniProtKB: P06493 (UniProtKB/Swiss-Prot),   A0A024QZJ8 (UniProtKB/TrEMBL),   I6L9I5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001163878   ⟸   NM_001170407
- Peptide Label: isoform 4
- UniProtKB: B7Z3D6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_005270360   ⟸   XM_005270303
- Peptide Label: isoform X1
- UniProtKB: P06493 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001307847   ⟸   NM_001320918
- Peptide Label: isoform 1
- UniProtKB: P06493 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSP00000430665   ⟸   ENST00000519078
RefSeq Acc Id: ENSP00000362915   ⟸   ENST00000373809
RefSeq Acc Id: ENSP00000482996   ⟸   ENST00000614696
RefSeq Acc Id: ENSP00000397973   ⟸   ENST00000448257
RefSeq Acc Id: ENSP00000378699   ⟸   ENST00000395284
RefSeq Acc Id: ENSP00000325970   ⟸   ENST00000316629
Protein Domains
Protein kinase

Promoters
RGD ID:7217621
Promoter ID:EPDNEW_H14556
Type:multiple initiation site
Name:CDK1_2
Description:cyclin dependent kinase 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H14555  EPDNEW_H14557  
Experiment Methods:Single-end sequencing.; Paired-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381060,778,345 - 60,778,405EPDNEW
RGD ID:7217623
Promoter ID:EPDNEW_H14557
Type:initiation region
Name:CDK1_1
Description:cyclin dependent kinase 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H14555  EPDNEW_H14556  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381060,778,478 - 60,778,538EPDNEW
RGD ID:6787457
Promoter ID:HG_KWN:9699
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   CD4+TCell_12Hour,   HeLa_S3,   Jurkat,   K562,   Lymphoblastoid,   NB4
Transcripts:ENST00000307250,   ENST00000373811,   ENST00000395284,   NM_001170406,   NM_001170407,   NM_001786,   NM_033379,   OTTHUMT00000048213,   UC001JLE.1,   UC001JLF.1
Position:
Human AssemblyChrPosition (strand)Source
Build 361062,207,991 - 62,208,491 (+)MPROMDB
RGD ID:6852952
Promoter ID:EP74295
Type:initiation region
Name:HS_CDC2
Description:Cell division cycle 2, G1 to S and G2 to M.
SO ACC ID:SO:0000170
Source:EPD (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Mammalian gene collection (MGC) full-length cDNA cloning
Position:
Human AssemblyChrPosition (strand)Source
Build 361062,208,257 - 62,208,317EPD
RGD ID:6787458
Promoter ID:HG_KWN:9700
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:HeLa_S3,   Jurkat
Transcripts:ENST00000373809,   OTTHUMT00000048214
Position:
Human AssemblyChrPosition (strand)Source
Build 361062,209,151 - 62,209,651 (+)MPROMDB

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 10q21.1-22.2(chr10:58436466-74415216)x1 copy number loss See cases [RCV000052511] Chr10:58436466..74415216 [GRCh38]
Chr10:60196226..76174974 [GRCh37]
Chr10:59866232..75844980 [NCBI36]
Chr10:10q21.1-22.2
pathogenic
GRCh38/hg38 10q11.21-22.2(chr10:42685306-73715908)x3 copy number gain See cases [RCV000134848] Chr10:42685306..73715908 [GRCh38]
Chr10:43180754..75475666 [GRCh37]
Chr10:42500760..75145672 [NCBI36]
Chr10:10q11.21-22.2
pathogenic
GRCh38/hg38 10q11.23-23.2(chr10:50729367-87147204)x3 copy number gain See cases [RCV000138007] Chr10:50729367..87147204 [GRCh38]
Chr10:52489127..88906961 [GRCh37]
Chr10:52159133..88896941 [NCBI36]
Chr10:10q11.23-23.2
pathogenic
GRCh38/hg38 10q21.1-21.3(chr10:55287177-67558442)x3 copy number gain See cases [RCV000141179] Chr10:55287177..67558442 [GRCh38]
Chr10:57046937..69318200 [GRCh37]
Chr10:56716943..68988206 [NCBI36]
Chr10:10q21.1-21.3
pathogenic
GRCh38/hg38 10q11.21-21.3(chr10:42112187-67400675)x3 copy number gain See cases [RCV000142967] Chr10:42112187..67400675 [GRCh38]
Chr10:42607635..69160433 [GRCh37]
Chr10:41927641..68830439 [NCBI36]
Chr10:10q11.21-21.3
pathogenic
GRCh37/hg19 10p15.3-q26.3(chr10:93297-135378918)x3 copy number gain See cases [RCV000448750] Chr10:93297..135378918 [GRCh37]
Chr10:10p15.3-q26.3
pathogenic
GRCh37/hg19 10q21.1-21.2(chr10:57587928-64212007)x1 copy number loss See cases [RCV000512057] Chr10:57587928..64212007 [GRCh37]
Chr10:10q21.1-21.2
likely pathogenic
GRCh37/hg19 10p15.3-q26.3(chr10:100027-135427143) copy number gain See cases [RCV000511389] Chr10:100027..135427143 [GRCh37]
Chr10:10p15.3-q26.3
pathogenic|uncertain significance
GRCh37/hg19 10p15.3-q26.3(chr10:100027-135427143)x3 copy number gain See cases [RCV000510861] Chr10:100027..135427143 [GRCh37]
Chr10:10p15.3-q26.3
pathogenic
GRCh37/hg19 10q11.21-26.3(chr10:42347406-135534747)x1 copy number loss Poly (ADP-Ribose) polymerase inhibitor response [RCV000626438] Chr10:42347406..135534747 [GRCh37]
Chr10:10q11.21-26.3
drug response
GRCh37/hg19 10p15.3-q26.3(chr10:73232-135524321)x3 copy number gain not provided [RCV000749464] Chr10:73232..135524321 [GRCh37]
Chr10:10p15.3-q26.3
pathogenic
GRCh37/hg19 10p15.3-q26.3(chr10:98087-135477883)x3 copy number gain not provided [RCV000749465] Chr10:98087..135477883 [GRCh37]
Chr10:10p15.3-q26.3
pathogenic
NM_001786.5(CDK1):c.642C>T (p.Phe214=) single nucleotide variant not provided [RCV000882617] Chr10:60792042 [GRCh38]
Chr10:62551800 [GRCh37]
Chr10:10q21.2
benign
GRCh37/hg19 10q21.2-21.3(chr10:62191184-65348431)x1 copy number loss not provided [RCV001006330] Chr10:62191184..65348431 [GRCh37]
Chr10:10q21.2-21.3
uncertain significance
GRCh37/hg19 10q21.1-21.2(chr10:59199424-62981900)x3 copy number gain not provided [RCV000848715] Chr10:59199424..62981900 [GRCh37]
Chr10:10q21.1-21.2
uncertain significance
GRCh37/hg19 10q21.1-21.2(chr10:55589950-63990649)x1 copy number loss not provided [RCV001006325] Chr10:55589950..63990649 [GRCh37]
Chr10:10q21.1-21.2
pathogenic
GRCh37/hg19 10q11.23-21.3(chr10:50250603-69256083)x1 copy number loss not provided [RCV001006319] Chr10:50250603..69256083 [GRCh37]
Chr10:10q11.23-21.3
pathogenic
GRCh37/hg19 10q21.1-21.3(chr10:56031210-65660398)x1 copy number loss not provided [RCV001006326] Chr10:56031210..65660398 [GRCh37]
Chr10:10q21.1-21.3
pathogenic

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:1722 AgrOrtholog
COSMIC CDK1 COSMIC
Ensembl Genes ENSG00000170312 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSP00000325970 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSP00000362915 UniProtKB/Swiss-Prot
  ENSP00000378699 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSP00000397973 ENTREZGENE, UniProtKB/TrEMBL
  ENSP00000430665 UniProtKB/TrEMBL
  ENSP00000482996 UniProtKB/TrEMBL
Ensembl Transcript ENST00000316629 ENTREZGENE, UniProtKB/Swiss-Prot
  ENST00000373809 UniProtKB/Swiss-Prot
  ENST00000395284 ENTREZGENE, UniProtKB/Swiss-Prot
  ENST00000448257 ENTREZGENE, UniProtKB/TrEMBL
  ENST00000475504 ENTREZGENE
  ENST00000519078 UniProtKB/TrEMBL
  ENST00000614696 UniProtKB/TrEMBL
GTEx ENSG00000170312 GTEx
HGNC ID HGNC:1722 ENTREZGENE
Human Proteome Map CDK1 Human Proteome Map
InterPro Kinase-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ser/Thr_kinase_AS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:983 UniProtKB/Swiss-Prot
NCBI Gene 983 ENTREZGENE
OMIM 116940 OMIM
Pfam Pkinase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB CDC2 RGD, PharmGKB
PROSITE PROTEIN_KINASE_ATP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PROTEIN_KINASE_ST UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART S_TKc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF56112 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A024QZJ8 ENTREZGENE, UniProtKB/TrEMBL
  A0A024QZP7_HUMAN UniProtKB/TrEMBL
  A0A087WZZ9_HUMAN UniProtKB/TrEMBL
  B7Z3D6 ENTREZGENE, UniProtKB/TrEMBL
  CDK1_HUMAN UniProtKB/Swiss-Prot
  E5RIU6_HUMAN UniProtKB/TrEMBL
  I6L9I5 ENTREZGENE, UniProtKB/TrEMBL
  P06493 ENTREZGENE
UniProt Secondary A8K7C4 UniProtKB/Swiss-Prot
  C9J497 UniProtKB/Swiss-Prot
  O60764 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-06-21 CDK1  cyclin dependent kinase 1    cyclin-dependent kinase 1  Symbol and/or name change 5135510 APPROVED
2011-08-16 CDK1  cyclin-dependent kinase 1  CDK1  cyclin-dependent kinase 1  Symbol and/or name change 5135510 APPROVED
2011-07-27 CDK1  cyclin-dependent kinase 1  CDC2  cell division cycle 2, G1 to S and G2 to M  Symbol and/or name change 5135510 APPROVED