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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2319
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cdk1
Name: cyclin-dependent kinase 1
Acc ID: CHEBI:9168
Term: sirolimus
Definition: A macrolide lactam isolated from Streptomyces hygroscopicus consisting of a 29-membered ring containing 4 trans double bonds, three of which are conjugated. It is an antibiotic, immunosupressive and antineoplastic agent.
Chemical ID: MESH:D020123
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cdk1decreases activityEXP 6480464CTDSirolimus results in decreased activity of CDK1 proteinPMID:7532117
Cdk1decreases activityISOCdk1 (Mus musculus)6480464CTDSirolimus results in decreased activity of CDK1 proteinPMID:7503980
Cdk1decreases expressionISOCDK1 (Homo sapiens)6480464CTDSirolimus results in decreased expression of CDK1PMID:8419408
Cdk1decreases expressionISOCdk1 (Mus musculus)6480464CTDSirolimus results in decreased expression of CDK1 mRNA; Sirolimus results in decreased expression of CDK1 proteinPMID:19922502
Cdk1multiple interactionsISOCDK1 (Homo sapiens)6480464CTD[7-hydroxystaurosporine co-treated with Sirolimus] results in decreased expression of CDK1 mRNA; [7-hydroxystaurosporine co-treated with Sirolimus] results in decreased expression of CDK1 protein; [7-hydroxystaurosporine co-treated with Sirolimus] results in decreased phosphorylation of CDK1 protein; [fulvestrant co-treated with Sirolimus] results in decreased expression of CDK1 mRNAPMID:15767555 PMID:19016759 PMID:19223503
Cdk1multiple interactionsISOCdk1 (Mus musculus)6480464CTDSirolimus inhibits the reaction [IL2 protein results in increased expression of CDK1 mRNA]PMID:11355896
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