RGD Reference Report - Shengmai-san-mediated enhancement of regenerative responses of spinal cord axons after injury in rats. - Rat Genome Database

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Shengmai-san-mediated enhancement of regenerative responses of spinal cord axons after injury in rats.

Authors: Seo, TB  Baek, K  Kwon, KB  Lee, SI  Lim, JS  Seol, IC  Kim, YS  Seo, YB  Namgung, U 
Citation: Seo TB, etal., J Pharmacol Sci. 2009 Aug;110(4):483-92.
RGD ID: 2316488
Pubmed: PMID:19672039   (View Abstract at PubMed)

Shengmai-san (SMS) is a traditional Chinese medicine used to treat diverse symptoms including cardiovascular and neurological disorders. Here we investigated the effects of SMS on regenerative responses of spinal cord axons in rats that were given contusion injury at the lower thoracic level. The injury cavity was confined to a restricted area by SMS treatment, and the signals of glial scar protein chondroitin sulphate proteoglycan (CSPG) and inflammatory cell marker protein CD11beta were heavily observed within the injury cavity in SMS-treated animals. Anterograde tracing of DiI-labeled corticospinal tract (CST) axons revealed increases in collateral arborization around and within the injury cavity and caudal elongation by SMS treatment. Furthermore, SMS treatment facilitated neurite elongation of dorsal root ganglion (DRG) sensory neurons that were co-cultured with non-neuronal cells prepared from injured spinal cord. Phospho-Erk1/2 was strongly induced in both spinal cord and motor cortical areas after spinal cord injury (SCI), and it was further unregulated in the motor cortex by SMS treatment. In contrast, upregulation of cell division cycle 2 (Cdc2) production by SMS treatment was limited to a local, SCI area. These data suggest that SMS may play an active role in regenerative responses and facilitate axonal regrowth after SCI.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
Spinal Cord Injuries  ISOCdk1 (Rattus norvegicus)2316488; 2316488protein:increased expression:spinal cord dura mater (rat)RGD 
Spinal Cord Injuries  IEP 2316488protein:increased expression:spinal cord dura mater (rat)RGD 

Objects Annotated

Genes (Rattus norvegicus)
Cdk1  (cyclin-dependent kinase 1)

Genes (Mus musculus)
Cdk1  (cyclin dependent kinase 1)

Genes (Homo sapiens)
CDK1  (cyclin dependent kinase 1)


Additional Information