Cdk1 (cyclin dependent kinase 1) - Rat Genome Database

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Gene: Cdk1 (cyclin dependent kinase 1) Mus musculus
Symbol: Cdk1
Name: cyclin dependent kinase 1 (Ensembl:cyclin-dependent kinase 1)
RGD ID: 731890
Description: Enables Hsp70 protein binding activity; chromatin binding activity; and cyclin-dependent protein serine/threonine kinase activity. Acts upstream of or within several processes, including fibroblast proliferation; mitotic G2 DNA damage checkpoint signaling; and mitotic cell cycle phase transition. Colocalizes with mitochondrial matrix. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in breast cancer; cervical cancer; and urinary bladder cancer. Orthologous to human CDK1 (cyclin dependent kinase 1).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Cdc2; Cdc2a; cell cycle p34 CDC2 kinase protein; cell division control protein 2 homolog; cell division cycle 2 homolog A; cell division cycle control protein 2a; cell division protein kinase 1; cyclin-dependent kinase 1; p34 protein kinase; p34
RGD Orthologs
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Related Pseudogenes: Gm18371   Gm49852  
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm391069,170,976 - 69,188,742 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1069,170,976 - 69,188,768 (-)EnsemblGRCm39 Ensembl
GRCm381069,335,146 - 69,352,912 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1069,335,146 - 69,352,938 (-)EnsemblGRCm38mm10GRCm38
MGSCv371068,799,383 - 68,815,660 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361068,731,992 - 68,748,269 (-)NCBIMGSCv36mm8
Celera1070,426,785 - 70,443,097 (-)NCBICelera
Cytogenetic Map10B5.3NCBI
cM Map1036.07NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-catechin  (ISO)
(+)-pilocarpine  (ISO)
(-)-citrinin  (ISO)
(-)-demecolcine  (ISO)
(1->4)-beta-D-glucan  (EXP)
(1S)-bornane-2,3-dione  (ISO)
(20R)-protopanaxadiol  (ISO)
(S)-naringenin  (ISO)
(S)-nicotine  (ISO)
1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane  (EXP)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (EXP,ISO)
1,1-dichloroethene  (EXP)
1,2-dimethylhydrazine  (EXP)
1,3-dinitrobenzene  (EXP,ISO)
1-chloro-2,4-dinitrobenzene  (EXP)
1-naphthyl isothiocyanate  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (EXP)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrotoluene  (ISO)
2-acetamidofluorene  (ISO)
2-amino-2-deoxy-D-glucopyranose  (ISO)
2-methoxy-17beta-estradiol  (ISO)
2-methylcholine  (ISO)
2-nitrofluorene  (ISO)
2-trans,6-trans,10-trans-geranylgeranyl diphosphate  (ISO)
3',4',5-trihydroxy-3,7-dimethoxyflavone  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3-[(4-anilinophenyl)diazenyl]benzene-1-sulfonic acid  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (EXP)
4-(ethoxymethylene)-2-phenyloxazol-5-one  (EXP)
4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one  (ISO)
4-hydroxyphenyl retinamide  (EXP,ISO)
4-nitrophenol  (EXP)
4-phenylbutyric acid  (ISO)
5-aza-2'-deoxycytidine  (EXP,ISO)
5-azacytidine  (ISO)
5-fluorouracil  (EXP,ISO)
5-formyltetrahydrofolic acid  (ISO)
6-propyl-2-thiouracil  (ISO)
acetamide  (ISO)
aconitine  (EXP,ISO)
acrylamide  (ISO)
afimoxifene  (ISO)
aflatoxin B1  (EXP,ISO)
aflatoxin M1  (ISO)
alachlor  (ISO)
aldehydo-D-glucosamine  (ISO)
all-trans-retinoic acid  (ISO)
alpha-hexylcinnamaldehyde  (EXP)
alpha-naphthoflavone  (ISO)
alvocidib  (ISO)
amifostine  (ISO)
ammonium chloride  (ISO)
anthocyanin  (ISO)
anthra[1,9-cd]pyrazol-6(2H)-one  (EXP,ISO)
antimycin A  (ISO)
apigenin  (ISO)
arecoline  (ISO)
aristolochic acid A  (ISO)
aristolochic acids  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (EXP,ISO)
arsenous acid  (ISO)
atenolol  (EXP)
atrazine  (EXP)
atropine  (ISO)
auraptene  (ISO)
azathioprine  (ISO)
baicalein  (ISO)
belinostat  (ISO)
benzene  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[b]fluoranthene  (EXP)
benzophenone  (ISO)
beta-D-glucosamine  (ISO)
beta-naphthoflavone  (ISO)
bexarotene  (ISO)
bicalutamide  (ISO)
biphenyl-4-amine  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
Bisphenol A glycidylmethacrylate  (ISO)
Bisphenol B  (ISO)
bisphenol F  (EXP)
bortezomib  (ISO)
bryostatin 1  (ISO)
buspirone  (ISO)
buta-1,3-diene  (EXP)
butylated hydroxyanisole  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
caffeine  (EXP,ISO)
calcitriol  (ISO)
camptothecin  (ISO)
cannabidiol  (ISO)
capsaicin  (ISO)
carbon nanotube  (EXP)
catechol  (ISO)
cefaloridine  (ISO)
CGP 52608  (ISO)
chlorambucil  (ISO)
chlorendic acid  (ISO)
chloroprene  (EXP)
choline  (EXP)
chromium atom  (ISO)
chromium(6+)  (EXP,ISO)
ciglitazone  (ISO)
ciprofloxacin  (ISO)
cisplatin  (EXP,ISO)
clofibrate  (ISO)
clotrimazole  (ISO)
cobalt dichloride  (ISO)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
copper(II) sulfate  (ISO)
corosolic acid  (EXP)
corticosterone  (ISO)
coumarin  (ISO)
coumestrol  (ISO)
crocidolite asbestos  (ISO)
cucurbitacin I  (ISO)
Cuprizon  (ISO)
curcumin  (ISO)
cyanocob(III)alamin  (EXP)
cyclosporin A  (ISO)
cytochalasin B  (ISO)
deguelin  (ISO)
deoxynivalenol  (ISO)
dexamethasone  (ISO)
diallyl disulfide  (ISO)
diallyl trisulfide  (ISO)
diarsenic trioxide  (ISO)
diazinon  (ISO)
dibenz[a,h]anthracene  (EXP)
dibutyl phthalate  (ISO)
dicrotophos  (ISO)
dieldrin  (ISO)
diepoxybutane  (EXP)
diethylstilbestrol  (ISO)
digitoxin  (ISO)
Diosbulbin B  (EXP,ISO)
dioscin  (ISO)
dioxygen  (ISO)
diuron  (ISO)
dorsomorphin  (ISO)
doxorubicin  (EXP,ISO)
Echimidine  (ISO)
elemental selenium  (ISO)
ellagic acid  (ISO)
ellipticine  (ISO)
endosulfan  (ISO)
Enterolactone  (ISO)
enzyme inhibitor  (ISO)
erythromycin estolate  (ISO)
ethanol  (EXP,ISO)
fenbendazole  (ISO)
fenpyroximate  (ISO)
fipronil  (ISO)
fisetin  (ISO)
flumequine  (EXP)
folic acid  (EXP,ISO)
fulvestrant  (ISO)
furan  (ISO)
gamma-linolenic acid  (ISO)
gamma-tocopherol  (EXP)
gefitinib  (EXP)
genistein  (ISO)
gentamycin  (ISO)
geraniol  (ISO)
gingerol  (ISO)
glycidol  (ISO)
glycine betaine  (EXP)
Goe 6976  (ISO)
gold atom  (ISO)
gold(0)  (ISO)
guggulsterone  (ISO)
GW 4064  (ISO)
harmine  (ISO)
hellebrigenin  (ISO)
hydrogen peroxide  (ISO)
hydroxamic acid  (ISO)
indirubin  (ISO)
inuviscolide  (ISO)
irinotecan  (ISO)
isoprenaline  (EXP)
ivermectin  (ISO)
kaempferol  (ISO)
ketamine  (ISO)
L-ascorbic acid  (ISO)
L-methionine  (EXP)
Lasiocarpine  (ISO)
lead diacetate  (ISO)
leflunomide  (ISO)
leptomycin B  (ISO)
levofloxacin  (ISO)
Licochalcone A  (ISO)
Licochalcone B  (ISO)
lidocaine  (ISO)
limonene  (ISO)
lipopolysaccharide  (ISO)
Longikaurin A  (ISO)
lucanthone  (ISO)
luteolin  (ISO)
luteolin 7-O-beta-D-glucoside  (ISO)
LY294002  (ISO)
lycopene  (ISO)
malachite green cation  (ISO)
mangiferin  (ISO)
mechlorethamine  (ISO)
melatonin  (EXP,ISO)
mercury dichloride  (ISO)
metformin  (ISO)
methamphetamine  (ISO)
methapyrilene  (ISO)
methotrexate  (ISO)
methyl salicylate  (EXP)
methylmercury chloride  (EXP)
methylparaben  (ISO)
methylseleninic acid  (ISO)
mevalonic acid  (ISO)
microcystin-LR  (ISO)
mifepristone  (ISO)
mitomycin C  (EXP)
ML-7  (ISO)
monocrotaline  (ISO)
morin  (ISO)
N-acetyl-L-cysteine  (EXP,ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (EXP)
N-methyl-4-phenylpyridinium  (ISO)
N-methyl-N-nitrosourea  (EXP,ISO)
N-nitrosodiethylamine  (EXP,ISO)
N-nitrosodimethylamine  (ISO)
N-Nitrosopyrrolidine  (ISO)
naphthalene  (EXP,ISO)
nickel atom  (ISO)
nickel subsulfide  (ISO)
nicotine  (ISO)
nimesulide  (ISO)
nitroprusside  (ISO)
nocodazole  (ISO)
nonanoic acid  (EXP)
O-methyleugenol  (ISO)
ochratoxin A  (EXP,ISO)
okadaic acid  (ISO)
olomoucine  (ISO)
omacetaxine mepesuccinate  (ISO)
orlistat  (ISO)
osthole  (ISO)
oxaliplatin  (ISO)
ozone  (EXP)
paclitaxel  (ISO)
palbociclib  (EXP,ISO)
Panduratin A  (ISO)
paracetamol  (ISO)
paraquat  (EXP)
parathion  (ISO)
PCB138  (EXP)
Pentoxifylline  (ISO)
perfluorodecanoic acid  (EXP)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (EXP)
perfluorooctanoic acid  (ISO)
PF-00477736  (ISO)
phenethyl caffeate  (ISO)
phenethyl isothiocyanate  (ISO)
phenformin  (ISO)
phenobarbital  (EXP,ISO)
phenytoin  (EXP)
phorbol 13-acetate 12-myristate  (EXP)
phthalaldehyde  (EXP)
phytoestrogen  (ISO)
picoxystrobin  (ISO)
picropodophyllotoxin  (ISO)
piperine  (EXP)
piperonyl butoxide  (ISO)
Pirarubicin  (ISO)
pirinixic acid  (EXP,ISO)
piroxicam  (ISO)
poly(propylene imine) macromolecule  (ISO)
potassium bromate  (ISO)
potassium dichromate  (ISO)
pregnenolone 16alpha-carbonitrile  (EXP)
procyanidin  (ISO)
progesterone  (ISO)
propanal  (ISO)
propiconazole  (EXP)
propofol  (ISO)
pyrimidifen  (ISO)
quercetin  (EXP,ISO)
quinolines  (ISO)
reactive oxygen species  (ISO)
resveratrol  (ISO)
riddelliine  (ISO)
rotenone  (ISO)
saccharin  (EXP)
SB 203580  (ISO)
selenium atom  (ISO)
seliciclib  (ISO)
silibinin  (ISO)
silicon dioxide  (EXP,ISO)
silver atom  (ISO)
silver(0)  (ISO)
silver(1+) nitrate  (ISO)
simvastatin  (ISO)
sirolimus  (EXP,ISO)
sodium arsenite  (EXP,ISO)
sodium chromate  (EXP)
sodium dichromate  (EXP,ISO)
Soman  (ISO)
sorafenib  (EXP)
SR 144528  (ISO)
sterigmatocystin  (ISO)
sulfadimethoxine  (ISO)
sulforaphane  (ISO)
sulindac  (ISO)
sunitinib  (ISO)
tamoxifen  (EXP,ISO)
tanespimycin  (ISO)
tebufenpyrad  (ISO)
temozolomide  (ISO)
terameprocol  (ISO)
tert-butyl hydroperoxide  (EXP)
testosterone  (EXP,ISO)
testosterone enanthate  (ISO)
tetrachloromethane  (EXP,ISO)
thalidomide  (ISO)
thapsigargin  (ISO)
thifluzamide  (ISO)
thimerosal  (ISO)
thioacetamide  (ISO)
titanium dioxide  (EXP,ISO)
tocopherol  (EXP)
toluene 2,4-diisocyanate  (EXP)
Tomentosin  (ISO)
topotecan  (ISO)
trabectedin  (ISO)
triazoles  (ISO)
Tributyltin oxide  (ISO)
trichloroethene  (EXP,ISO)
trichostatin A  (ISO)
trimellitic anhydride  (EXP)
Triptolide  (ISO)
triptonide  (EXP)
troglitazone  (ISO)
tropan-3alpha-yl 3-hydroxy-2-phenylpropanoate  (ISO)
trovafloxacin  (EXP,ISO)
tungsten  (EXP)
tunicamycin  (ISO)
tyrphostin AG 1478  (ISO)
urethane  (ISO)
vincaleukoblastine  (ISO)
vincristine  (ISO)
vorinostat  (ISO)
wortmannin  (ISO)
Xanthatin  (ISO)
xanthohumol  (ISO)
zaragozic acid A  (EXP,ISO)
zearalenone  (EXP)
zidovudine  (ISO)
zinc atom  (EXP)
zinc(0)  (EXP)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
animal organ regeneration  (ISO)
apoptotic process  (IEA)
cell division  (IEA)
cellular response to hydrogen peroxide  (ISO)
cellular response to organic cyclic compound  (ISO)
chromosome condensation  (ISO)
epithelial cell differentiation  (ISO)
fibroblast proliferation  (IDA)
G2/M transition of mitotic cell cycle  (IBA)
Golgi disassembly  (ISO)
meiotic cell cycle process involved in oocyte maturation  (ISO)
meiotic spindle organization  (ISO)
microtubule cytoskeleton organization involved in mitosis  (ISO)
mitotic cell cycle phase transition  (IMP)
mitotic G2 DNA damage checkpoint signaling  (IBA,IDA)
negative regulation of apoptotic process  (ISO)
negative regulation of gene expression  (ISO)
peptidyl-serine phosphorylation  (ISO)
peptidyl-threonine phosphorylation  (ISO)
phosphorylation  (IEA)
positive regulation of cardiac muscle cell proliferation  (ISO)
positive regulation of DNA replication  (ISO)
positive regulation of G2/M transition of mitotic cell cycle  (ISO)
positive regulation of gene expression  (ISO)
positive regulation of meiotic cell cycle process involved in oocyte maturation  (ISO)
positive regulation of mitochondrial ATP synthesis coupled electron transport  (ISO)
positive regulation of mitotic cell cycle  (ISO)
positive regulation of mitotic sister chromatid segregation  (ISO)
positive regulation of protein import into nucleus  (ISO)
positive regulation of protein localization to nucleus  (ISO)
protein localization to kinetochore  (ISO)
protein phosphorylation  (IBA,IDA,ISO)
protein-containing complex assembly  (ISO)
regulation of circadian rhythm  (ISO)
response to activity  (ISO)
response to amine  (ISO)
response to axon injury  (ISO)
response to cadmium ion  (ISO)
response to copper ion  (ISO)
response to ethanol  (ISO)
response to hydrogen peroxide  (ISO)
response to organic cyclic compound  (ISO)
response to organonitrogen compound  (ISO)
response to toxic substance  (ISO)
response to xenobiotic stimulus  (ISO)
rhythmic process  (IEA)
ventricular cardiac muscle cell development  (ISO)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype

References - curated
# Reference Title Reference Citation
1. Forkhead box M1B is a determinant of rat susceptibility to hepatocarcinogenesis and sustains ERK activity in human HCC. Calvisi DF, etal., Gut. 2009 May;58(5):679-87. Epub 2009 Jan 9.
2. Development of a multiplex RNA urine test for the detection and stratification of transitional cell carcinoma of the bladder. Holyoake A, etal., Clin Cancer Res. 2008 Feb 1;14(3):742-9.
3. Contribution of high p34cdc2 kinase activity to premature chromosome condensation of injected somatic cell nuclei in rat oocytes. Ito J, etal., Reproduction. 2005 Feb;129(2):171-80.
4. Determination of the specific activity of CDK1 and CDK2 as a novel prognostic indicator for early breast cancer. Kim SJ, etal., Ann Oncol. 2008 Jan;19(1):68-72. Epub 2007 Oct 22.
5. HYAL1-v1, an alternatively spliced variant of HYAL1 hyaluronidase: a negative regulator of bladder cancer. Lokeshwar VB, etal., Cancer Res. 2006 Dec 1;66(23):11219-27.
6. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
7. MGDs mouse GO annotations MGD data from the GO Consortium
8. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
9. Variation in genes required for normal mitosis and risk of breast cancer. Olson JE, etal., Breast Cancer Res Treat. 2010 Jan;119(2):423-30. Epub 2009 Apr 18.
10. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
11. Oral grape seed extract inhibits prostate tumor growth and progression in TRAMP mice. Raina K, etal., Cancer Res. 2007 Jun 15;67(12):5976-82.
12. Mouse MP Annotation Import Pipeline RGD automated import pipeline
13. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
14. Shengmai-san-mediated enhancement of regenerative responses of spinal cord axons after injury in rats. Seo TB, etal., J Pharmacol Sci. 2009 Aug;110(4):483-92.
15. Analysis of novel tumor markers in pancreatic and biliary carcinomas using tissue microarrays. Swierczynski SL, etal., Hum Pathol. 2004 Mar;35(3):357-66.
16. Plant-derived MINA-05 inhibits human prostate cancer proliferation in vitro and lymph node spread in vivo. Vandyke K, etal., Neoplasia. 2007 Apr;9(4):322-31.
17. Cellular distributions of molecules with altered expression specific to thyroid proliferative lesions developing in a rat thyroid carcinogenesis model. Woo GH, etal., Cancer Sci. 2009 Apr;100(4):617-25. Epub 2009 Feb 25.
18. Changes in gene expression induced by chemoradiation in advanced cervical carcinoma: a microarray study of RTOG C-0128. Zempolich K, etal., Gynecol Oncol. 2008 May;109(2):275-9. Epub 2008 Mar 4.
Additional References at PubMed
PMID:1302014   PMID:1371961   PMID:1426634   PMID:1832672   PMID:1975791   PMID:2132958   PMID:2208288   PMID:2662013   PMID:2844417   PMID:7604037   PMID:7624053   PMID:7673335  
PMID:7734049   PMID:7739547   PMID:7834371   PMID:8033995   PMID:8226784   PMID:8552401   PMID:8601034   PMID:8631505   PMID:8812475   PMID:8910336   PMID:9187143   PMID:9202329  
PMID:9247342   PMID:9371520   PMID:9416832   PMID:9438340   PMID:9547506   PMID:9843212   PMID:9895127   PMID:10349636   PMID:10430593   PMID:10559244   PMID:10913163   PMID:10922068  
PMID:11042159   PMID:11076861   PMID:11217851   PMID:11380680   PMID:11555636   PMID:11641775   PMID:11687586   PMID:12072567   PMID:12121977   PMID:12124778   PMID:12477932   PMID:12904583  
PMID:12934012   PMID:12937170   PMID:14561402   PMID:14610273   PMID:14681479   PMID:14695906   PMID:14749395   PMID:15142957   PMID:15159393   PMID:15315760   PMID:15489334   PMID:15531365  
PMID:15580572   PMID:15701524   PMID:15707957   PMID:15716349   PMID:15730892   PMID:15842198   PMID:15870191   PMID:15984162   PMID:16007079   PMID:16081423   PMID:16102754   PMID:16109376  
PMID:16141072   PMID:16141073   PMID:16159883   PMID:16183859   PMID:16260496   PMID:16456547   PMID:16678773   PMID:17000767   PMID:17093407   PMID:17098733   PMID:17108174   PMID:17160696  
PMID:17274640   PMID:17276355   PMID:17283331   PMID:17290426   PMID:17342725   PMID:17349584   PMID:17700700   PMID:17708348   PMID:17942597   PMID:18022836   PMID:18056802   PMID:18321792  
PMID:18356527   PMID:18374969   PMID:18425394   PMID:18505930   PMID:18550795   PMID:18606161   PMID:18625720   PMID:18635963   PMID:18787066   PMID:18799693   PMID:18981479   PMID:19106089  
PMID:19129496   PMID:19139267   PMID:19221029   PMID:19239702   PMID:19500387   PMID:19553603   PMID:19592082   PMID:19641176   PMID:19822658   PMID:19877273   PMID:20347762   PMID:20360068  
PMID:20362541   PMID:20444701   PMID:20516642   PMID:20729212   PMID:20798132   PMID:20974803   PMID:21210908   PMID:21267068   PMID:21289082   PMID:21328468   PMID:21440680   PMID:21454751  
PMID:21536733   PMID:21659531   PMID:21677750   PMID:21678139   PMID:21731673   PMID:21737879   PMID:21793718   PMID:21873635   PMID:21900237   PMID:22355113   PMID:22367880   PMID:22405274  
PMID:22442484   PMID:22465667   PMID:22513370   PMID:22649246   PMID:22766025   PMID:22854038   PMID:22859367   PMID:22957921   PMID:23108051   PMID:23341776   PMID:23342106   PMID:23479742  
PMID:23543736   PMID:23666531   PMID:23857768   PMID:24109598   PMID:24184637   PMID:24392139   PMID:24457600   PMID:24477232   PMID:24478334   PMID:24551245   PMID:24583015   PMID:24613310  
PMID:24637322   PMID:24746669   PMID:24821722   PMID:24886500   PMID:25139855   PMID:25161285   PMID:25196150   PMID:25246615   PMID:25264619   PMID:25422376   PMID:25445585   PMID:25450615  
PMID:25616574   PMID:25625205   PMID:25670854   PMID:25733019   PMID:26176233   PMID:26296893   PMID:26410627   PMID:26490841   PMID:26496610   PMID:26663909   PMID:26860366   PMID:26881434  
PMID:27034005   PMID:27117522   PMID:27141870   PMID:27352860   PMID:27358050   PMID:27565725   PMID:27631493   PMID:27767095   PMID:28094252   PMID:28224044   PMID:28272965   PMID:28378742  
PMID:28479321   PMID:28535371   PMID:28723571   PMID:28923932   PMID:29058287   PMID:29215012   PMID:29274320   PMID:29518391   PMID:29581894   PMID:29901724   PMID:29967281   PMID:30190546  
PMID:30279413   PMID:30366983   PMID:30429614   PMID:30700550   PMID:30971822   PMID:31358751   PMID:31427428   PMID:31704793   PMID:32232159   PMID:32240602   PMID:32554809   PMID:32703236  
PMID:32731332   PMID:32865279   PMID:33046531   PMID:33147210   PMID:33230847   PMID:33328221   PMID:33345777   PMID:33634103   PMID:33682352   PMID:33766930   PMID:33798452   PMID:34067359  
PMID:34571959   PMID:34746147   PMID:34851661   PMID:35012549   PMID:35508138   PMID:35770734   PMID:35883586   PMID:36092713   PMID:36114006   PMID:36139407   PMID:36178098   PMID:36681899  
PMID:36734965   PMID:37047236  


Comparative Map Data
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm391069,170,976 - 69,188,742 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1069,170,976 - 69,188,768 (-)EnsemblGRCm39 Ensembl
GRCm381069,335,146 - 69,352,912 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1069,335,146 - 69,352,938 (-)EnsemblGRCm38mm10GRCm38
MGSCv371068,799,383 - 68,815,660 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361068,731,992 - 68,748,269 (-)NCBIMGSCv36mm8
Celera1070,426,785 - 70,443,097 (-)NCBICelera
Cytogenetic Map10B5.3NCBI
cM Map1036.07NCBI
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh381060,778,331 - 60,794,852 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl1060,778,331 - 60,794,852 (+)EnsemblGRCh38hg38GRCh38
GRCh371062,538,089 - 62,554,610 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361062,205,690 - 62,223,930 (+)NCBINCBI36Build 36hg18NCBI36
Build 341062,209,916 - 62,223,930NCBI
Celera1055,803,740 - 55,820,255 (+)NCBICelera
Cytogenetic Map10q21.2NCBI
HuRef1056,527,463 - 56,544,301 (+)NCBIHuRef
CHM1_11062,820,315 - 62,836,829 (+)NCBICHM1_1
T2T-CHM13v2.01061,635,069 - 61,651,590 (+)NCBIT2T-CHM13v2.0
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
mRatBN7.22019,266,226 - 19,281,417 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2019,266,248 - 19,281,408 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2019,995,212 - 20,010,375 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.02019,347,690 - 19,362,853 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.02019,822,895 - 19,838,058 (+)NCBIRnor_WKY
Rnor_6.02020,576,341 - 20,591,510 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2020,576,377 - 20,591,549 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02022,694,883 - 22,709,860 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42020,018,044 - 20,044,030 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12020,031,843 - 20,057,830 (+)NCBI
Celera2020,642,946 - 20,658,475 (+)NCBICelera
RH 3.4 Map20252.37RGD
Cytogenetic Map20p11NCBI
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
ChiLan1.0 EnsemblNW_00495542514,210,680 - 14,226,474 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495542514,210,681 - 14,226,474 (+)NCBIChiLan1.0ChiLan1.0
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
NHGRI_mPanPan11072,997,903 - 73,021,569 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01057,314,692 - 57,331,261 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11059,647,993 - 59,664,434 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1059,647,993 - 59,664,434 (+)Ensemblpanpan1.1panPan2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
CanFam3.1412,884,106 - 12,899,203 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl412,883,385 - 12,899,197 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha413,089,613 - 13,104,900 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0413,149,444 - 13,169,783 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl413,148,851 - 13,178,179 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1413,127,253 - 13,147,585 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0413,245,048 - 13,265,394 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0413,555,896 - 13,576,243 (+)NCBIUU_Cfam_GSD_1.0
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
HiC_Itri_2NW_02440721368,214,228 - 68,227,370 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366142,300,513 - 2,313,624 (-)EnsemblSpeTri2.0
SpeTri2.0NW_0049366142,300,682 - 2,313,611 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
Sscrofa11.1 Ensembl1464,233,987 - 64,372,197 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11464,233,945 - 64,255,290 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21469,262,279 - 69,277,262 (+)NCBISscrofa10.2Sscrofa10.2susScr3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
ChlSab1.1970,475,736 - 70,492,947 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366604831,365,769 - 31,382,908 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
HetGla 1.0NW_0046247912,891,239 - 2,915,001 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Variants in Cdk1
679 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1273
Count of miRNA genes:630
Interacting mature miRNAs:786
Transcripts:ENSMUST00000020099, ENSMUST00000119827, ENSMUST00000123458, ENSMUST00000124054, ENSMUST00000129444, ENSMUST00000149474, ENSMUST00000152448
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1357740Obsty3_mobesity 3 (mouse)Not determined108235478116190980Mouse
1301386Sysbp1_msystolic blood pressure 1 (mouse)Not determined101010826587401095Mouse
1357825Kidpq2_mkidney weight percentage QTL 2 (mouse)Not determined101270405184079784Mouse
1357656Hrtq3_mheart weight QTL 3 (mouse)Not determined101270405184079784Mouse
1357864Scfpq1_msubcutaneous fat pad percentage QTL 1 (mouse)Not determined101270405184079784Mouse
39128215Lwq17_mliver weight QTL 17 (mouse)101270405184079784Mouse
4141956Egq7_mearly growth QTL 7 (mouse)Not determined1270405184079784Mouse
4141943W6q6_mweight 6 weeks QTL 6 (mouse)Not determined1270405184079784Mouse
4142272W10q5_mweight 10 weeks QTL 5 (mouse)Not determined1270405184079784Mouse
4142380W3q11_mweight 3 weeks QTL 11 (mouse)Not determined1270405184079784Mouse
1302067Scc9_mcolon tumor susceptibility 9 (mouse)Not determined1018259333125575232Mouse
27226772Tibl13_mtibia length 13, 10 week (mouse)1018875748129635869Mouse
1558757Eae34_mexperimental allergic encephalomyelitis susceptibility 34 (mouse)Not determined1021408154114217230Mouse
26884403Cvht8_mcranial vault height 8, 16 week (mouse)102287589991035862Mouse
26884426Cvht1_mcranial vault height 1, 5 week (mouse)1024675898121035905Mouse
27095920Pglq9_mpelvic girdle length QTL 9, 10 week (mouse)103377599670835830Mouse
27095911Pglq15_mpelvic girdle length QTL 15, 16 week (mouse)1039175996129635869Mouse
27226764Tibl19_mtibia length 19, 16 week (mouse)1039175996129635869Mouse
4141070Ltgq1_mliver triglyceride QTL 1 (mouse)Not determined4123732675237326Mouse
26884411Bzwq8_mbi-zygomatic width QTL 8, 10 week (mouse)1044876096115935905Mouse
26884407Bzwq14_mbi-zygomatic width QTL 14, 16 wee (mouse)1045476096120635905Mouse
26884400Huml5_mhumerus length 5, 16 week (mouse)104627609669235830Mouse
4142313Angvq1_mangiogenesis by VEGF QTL 1 (mouse)Not determined4672040382491121Mouse
4141159Phl2_mprogressive hearing loss 2 (mouse)Not determined104797449970112651Mouse
1302150Bbaa18_mB.burgdorferi-associated arthritis 18 (mouse)Not determined104933801283338157Mouse
10045641Jckm3_mjuvenile cystic kidney modifier 3 (mouse)Not determined104984818783848412Mouse
1300597Skull14_mskull morphology 14 (mouse)Not determined104984818783848412Mouse
4142169Pbwg16_mpostnatal body weight growth 16 (mouse)Not determined104984818783848412Mouse
1357737Hpcr2_mhepatocarcinogen resistance 2 (mouse)Not determined104984822283848397Mouse
1301966Lifespan2_mlife span 2 (mouse)Not determined104984822283848397Mouse
1301502Eae17_msusceptibility to experimental allergic encephalomyelitis 17 (mouse)Not determined105109149085091639Mouse
1300882Ath17_matherosclerosis 17 (mouse)Not determined105109149085091639Mouse
1301380Cia8_mcollagen induced arthritis QTL 8 (mouse)Not determined105149340082491121Mouse
14746991Manh68_mmandible shape 68 (mouse)105228049786280497Mouse
1301787Bsc1_mbrain size control 1 (mouse)Not determined105851696992517096Mouse
26884450Sklq15_mskull length QTL 15, 16 week (mouse)1059335822122335905Mouse
13208560Wght9_mweight 9 (mouse)1059835822120835905Mouse
38455999Lick3_mlick rate 3 (mouse)106187303169373082Mouse
26884424Zlq9_mzygomatic length QTL 9, 16 week (mouse)1063935779115935905Mouse
1302060El3_mepilepsy 3 (mouse)Not determined106549093899491121Mouse
1300533Aem3_manti-erythrocyte autoantibody modifier 3 (mouse)Not determined106549093899491121Mouse
1301737Insq9_minsulin QTL 9 (mouse)Not determined106549093899491121Mouse
1302035Lmb4_mlupus in MRL and B6 F2 cross (mouse)Not determined106684818792258673Mouse
26884447Sklq9_mskull length QTL 9, 10 week (mouse)1067335830111735905Mouse
26884430Zlq5_mzygomatic length QTL 5, 10 week (mouse)1067835830124835905Mouse

Markers in Region
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map10B5.3UniSTS
cM Map1038.0UniSTS



Reference Sequences
RefSeq Acc Id: ENSMUST00000020099   ⟹   ENSMUSP00000020099
RefSeq Status:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1069,170,976 - 69,188,768 (-)Ensembl
GRCm38.p6 Ensembl1069,335,146 - 69,352,938 (-)Ensembl
RefSeq Acc Id: ENSMUST00000119827   ⟹   ENSMUSP00000113184
RefSeq Status:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1069,174,154 - 69,188,733 (-)Ensembl
GRCm38.p6 Ensembl1069,338,324 - 69,352,903 (-)Ensembl
RefSeq Acc Id: ENSMUST00000123458
RefSeq Status:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1069,176,429 - 69,178,559 (-)Ensembl
GRCm38.p6 Ensembl1069,340,599 - 69,342,729 (-)Ensembl
RefSeq Acc Id: ENSMUST00000124054
RefSeq Status:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1069,180,835 - 69,188,740 (-)Ensembl
GRCm38.p6 Ensembl1069,345,005 - 69,352,910 (-)Ensembl
RefSeq Acc Id: ENSMUST00000129444
RefSeq Status:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1069,176,560 - 69,181,340 (-)Ensembl
GRCm38.p6 Ensembl1069,340,730 - 69,345,510 (-)Ensembl
RefSeq Acc Id: ENSMUST00000149474
RefSeq Status:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1069,176,634 - 69,181,264 (-)Ensembl
GRCm38.p6 Ensembl1069,340,804 - 69,345,434 (-)Ensembl
RefSeq Acc Id: ENSMUST00000152448   ⟹   ENSMUSP00000119085
RefSeq Status:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1069,176,596 - 69,186,660 (-)Ensembl
GRCm38.p6 Ensembl1069,340,766 - 69,350,830 (-)Ensembl
RefSeq Acc Id: NM_007659   ⟹   NP_031685
RefSeq Status: VALIDATED
Mouse AssemblyChrPosition (strand)Source
GRCm391069,170,976 - 69,188,742 (-)NCBI
GRCm381069,335,146 - 69,352,912 (-)NCBI
MGSCv371068,799,383 - 68,815,660 (-)RGD
Celera1070,426,785 - 70,443,097 (-)RGD
Reference Sequences
RefSeq Acc Id: NP_031685   ⟸   NM_007659
- UniProtKB: Q3TI12 (UniProtKB/Swiss-Prot),   P11440 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSMUSP00000113184   ⟸   ENSMUST00000119827
RefSeq Acc Id: ENSMUSP00000020099   ⟸   ENSMUST00000020099
RefSeq Acc Id: ENSMUSP00000119085   ⟸   ENSMUST00000152448
Protein Domains
Protein kinase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P11440-F1-model_v2 AlphaFold P11440 1-297 view protein structure

RGD ID:6819106
Promoter ID:MM_KWN:4446
SO ACC ID:SO:0000170
Tissues & Cell Lines:BoneMarrow_0Hour
Mouse AssemblyChrPosition (strand)Source
MGSCv361068,805,211 - 68,805,962 (-)MPROMDB
RGD ID:6819108
Promoter ID:MM_KWN:4447
SO ACC ID:SO:0000170
Tissues & Cell Lines:BoneMarrow_0Hour,   Brain
Transcripts:OTTMUST00000077451,   OTTMUST00000077452
Mouse AssemblyChrPosition (strand)Source
MGSCv361068,807,941 - 68,808,662 (-)MPROMDB
RGD ID:6819101
Promoter ID:MM_KWN:4450
SO ACC ID:SO:0000170
Tissues & Cell Lines:BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   ES_Cell,   MEF_B4
Transcripts:ENSMUST00000119827,   OTTMUST00000077410,   OTTMUST00000077450
Mouse AssemblyChrPosition (strand)Source
MGSCv361068,815,384 - 68,815,884 (-)MPROMDB
RGD ID:8672226
Promoter ID:EPDNEW_M14143
Type:initiation region
Description:Mus musculus cyclin-dependent kinase 1 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database,
Experiment Methods:Single-end sequencing.
Mouse AssemblyChrPosition (strand)Source
GRCm381069,352,912 - 69,352,972EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:88351 AgrOrtholog
Ensembl Genes ENSMUSG00000019942 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSMUSP00000020099 ENTREZGENE
  ENSMUSP00000020099.6 UniProtKB/Swiss-Prot
  ENSMUSP00000113184.2 UniProtKB/Swiss-Prot
  ENSMUSP00000119085.2 UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000020099 ENTREZGENE
  ENSMUST00000020099.13 UniProtKB/Swiss-Prot
  ENSMUST00000119827.8 UniProtKB/Swiss-Prot
  ENSMUST00000152448.2 UniProtKB/TrEMBL
Gene3D-CATH Transferase(Phosphotransferase) domain 1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Kinase-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ser/Thr_kinase_AS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:12534 UniProtKB/Swiss-Prot
Pfam Pkinase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Cdk1 PhenoGen
SMART S_TKc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF56112 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt CDK1_MOUSE UniProtKB/Swiss-Prot
UniProt Secondary P70337 UniProtKB/Swiss-Prot
  Q3TI12 UniProtKB/Swiss-Prot

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2023-05-02 Cdk1  cyclin dependent kinase 1  Cdk1  cyclin-dependent kinase 1  Symbol and/or name change 5135510 APPROVED