CDK1 (cyclin dependent kinase 1) - Rat Genome Database

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Gene: CDK1 (cyclin dependent kinase 1) Sus scrofa
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Symbol: CDK1
Name: cyclin dependent kinase 1
RGD ID: 14208051
Description: ENCODES a protein that exhibits cyclin binding (ortholog); histone kinase activity (ortholog); INVOLVED IN meiotic cell cycle process involved in oocyte maturation; meiotic spindle organization; positive regulation of meiotic cell cycle process involved in oocyte maturation; ASSOCIATED WITH breast cancer (ortholog); cervical cancer (ortholog); COVID-19 (ortholog); FOUND IN endoplasmic reticulum exit site; germinal vesicle; cytoplasm (ortholog); INTERACTS WITH zearalenone
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: CDC2; cell division cycle 2, G1 to S and G2 to M; cyclin-dependent kinase 1
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1464,233,988 - 64,395,453 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11464,233,945 - 64,255,290 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21469,262,279 - 69,277,262 (+)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
zearalenone  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
animal organ regeneration  (ISO)
cell aging  (ISO)
cell division  (IEA)
cell population proliferation  (IEA,ISO)
cellular response to hydrogen peroxide  (ISO)
chromosome condensation  (ISO)
epithelial cell differentiation  (IEA)
G2/M transition of mitotic cell cycle  (IBA)
Golgi disassembly  (ISO)
histone phosphorylation  (IEA)
meiotic cell cycle process involved in oocyte maturation  (IMP)
meiotic spindle organization  (IMP)
mitotic cell cycle  (ISO)
mitotic cell cycle phase transition  (IEA,ISO)
mitotic G2 DNA damage checkpoint signaling  (IBA,IEA,ISO)
negative regulation of apoptotic process  (IEA)
negative regulation of gene expression  (ISO)
peptidyl-serine phosphorylation  (IEA)
peptidyl-threonine phosphorylation  (IEA)
phosphorylation  (IEA)
positive regulation of cardiac muscle cell proliferation  (ISO)
positive regulation of DNA replication  (ISO)
positive regulation of G2/M transition of mitotic cell cycle  (IEA)
positive regulation of gene expression  (ISO)
positive regulation of meiotic cell cycle process involved in oocyte maturation  (IMP)
positive regulation of mitochondrial ATP synthesis coupled electron transport  (IEA)
positive regulation of mitotic cell cycle  (ISO)
positive regulation of protein import into nucleus  (ISO)
positive regulation of protein localization to nucleus  (IEA)
protein localization to kinetochore  (IEA)
protein phosphorylation  (IBA,IEA,ISO)
protein-containing complex assembly  (ISO)
regulation of circadian rhythm  (IEA)
response to activity  (ISO)
response to amine  (ISO)
response to axon injury  (ISO)
response to cadmium ion  (ISO)
response to copper ion  (ISO)
response to ethanol  (ISO)
response to hydrogen peroxide  (ISO)
response to organic cyclic compound  (ISO)
response to organonitrogen compound  (ISO)
response to toxic substance  (ISO)
response to xenobiotic stimulus  (ISO)
ventricular cardiac muscle cell development  (ISO)

Cellular Component

References
Additional References at PubMed
PMID:10737969   PMID:14681463   PMID:15265077   PMID:19187565   PMID:19479986   PMID:19550110   PMID:19633431   PMID:19705412   PMID:21778139  


Genomics

Comparative Map Data
CDK1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1464,233,988 - 64,395,453 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11464,233,945 - 64,255,290 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21469,262,279 - 69,277,262 (+)NCBISscrofa10.2Sscrofa10.2susScr3
CDK1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1060,778,331 - 60,794,852 (+)EnsemblGRCh38hg38GRCh38
GRCh381060,778,331 - 60,794,852 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371062,538,089 - 62,554,610 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361062,205,690 - 62,223,930 (+)NCBINCBI36hg18NCBI36
Build 341062,209,916 - 62,223,930NCBI
Celera1055,803,740 - 55,820,255 (+)NCBI
Cytogenetic Map10q21.2NCBI
HuRef1056,527,463 - 56,544,301 (+)NCBIHuRef
CHM1_11062,820,315 - 62,836,829 (+)NCBICHM1_1
Cdk1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391069,170,976 - 69,188,742 (-)NCBIGRCm39mm39
GRCm39 Ensembl1069,170,976 - 69,188,768 (-)Ensembl
GRCm381069,335,146 - 69,352,912 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1069,335,146 - 69,352,938 (-)EnsemblGRCm38mm10GRCm38
MGSCv371068,799,383 - 68,815,660 (-)NCBIGRCm37mm9NCBIm37
MGSCv361068,731,992 - 68,748,269 (-)NCBImm8
Celera1070,426,785 - 70,443,097 (-)NCBICelera
Cytogenetic Map10B5.3NCBI
cM Map1036.07NCBI
Cdk1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.22019,266,226 - 19,281,417 (+)NCBImRatBN7.2
mRatBN7.2 Ensembl2019,266,248 - 19,281,408 (+)Ensembl
Rnor_6.02020,576,341 - 20,591,510 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2020,576,377 - 20,591,549 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02022,694,883 - 22,709,860 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42020,018,044 - 20,044,030 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.12020,031,843 - 20,057,830 (+)NCBI
Celera2020,642,946 - 20,658,475 (+)NCBICelera
RH 3.4 Map20252.37RGD
Cytogenetic Map20p11NCBI
Cdk1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542514,210,680 - 14,226,474 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495542514,210,681 - 14,226,474 (+)NCBIChiLan1.0ChiLan1.0
CDK1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11059,647,993 - 59,664,434 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1059,647,993 - 59,664,434 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01057,314,692 - 57,331,261 (+)NCBIMhudiblu_PPA_v0panPan3
CDK1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1412,884,106 - 12,899,203 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl412,883,385 - 12,899,197 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha413,089,613 - 13,104,900 (+)NCBI
ROS_Cfam_1.0413,149,444 - 13,169,783 (+)NCBI
ROS_Cfam_1.0 Ensembl413,148,851 - 13,178,179 (+)Ensembl
UMICH_Zoey_3.1413,127,253 - 13,147,585 (+)NCBI
UNSW_CanFamBas_1.0413,245,048 - 13,265,394 (+)NCBI
UU_Cfam_GSD_1.0413,555,896 - 13,576,243 (+)NCBI
Cdk1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440721368,214,228 - 68,227,370 (-)NCBI
SpeTri2.0NW_0049366142,300,682 - 2,313,611 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CDK1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1970,475,736 - 70,492,947 (-)NCBIChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366604831,365,769 - 31,382,908 (-)NCBIVero_WHO_p1.0
Cdk1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247912,891,239 - 2,915,001 (-)NCBIHetGla_female_1.0hetGla2


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system hemolymphoid system musculoskeletal system nervous system renal system reproductive system respiratory system
High
Medium 1 1 2 1
Low 9 1 3 1 3 2
Below cutoff 2 3 2 19 2

Sequence


Reference Sequences
RefSeq Acc Id: ENSSSCT00000011180   ⟹   ENSSSCP00000010890
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1464,235,981 - 64,245,902 (+)Ensembl
RefSeq Acc Id: ENSSSCT00000050632   ⟹   ENSSSCP00000044214
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1464,233,988 - 64,317,553 (+)Ensembl
RefSeq Acc Id: ENSSSCT00000065464   ⟹   ENSSSCP00000039536
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1464,234,004 - 64,299,292 (+)Ensembl
RefSeq Acc Id: ENSSSCT00000073736   ⟹   ENSSSCP00000071051
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1464,233,988 - 64,317,553 (+)Ensembl
RefSeq Acc Id: ENSSSCT00000077530   ⟹   ENSSSCP00000068701
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1464,233,997 - 64,395,453 (+)Ensembl
RefSeq Acc Id: NM_001159304   ⟹   NP_001152776
RefSeq Status: VALIDATED
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11464,233,989 - 64,248,926 (+)NCBI
Sequence:
RefSeq Acc Id: XM_005671013   ⟹   XP_005671070
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11464,233,992 - 64,255,290 (+)NCBI
Sequence:
RefSeq Acc Id: XM_005671016   ⟹   XP_005671073
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11464,233,945 - 64,255,290 (+)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: XP_005671073   ⟸   XM_005671016
- Peptide Label: isoform X1
- UniProtKB: C0SW08 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001152776   ⟸   NM_001159304
- UniProtKB: C0SW08 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_005671070   ⟸   XM_005671013
- Peptide Label: isoform X1
- UniProtKB: C0SW08 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSSSCP00000044214   ⟸   ENSSSCT00000050632
RefSeq Acc Id: ENSSSCP00000071051   ⟸   ENSSSCT00000073736
RefSeq Acc Id: ENSSSCP00000039536   ⟸   ENSSSCT00000065464
RefSeq Acc Id: ENSSSCP00000010890   ⟸   ENSSSCT00000011180
RefSeq Acc Id: ENSSSCP00000068701   ⟸   ENSSSCT00000077530
Protein Domains
Protein kinase


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000010214 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSSSCP00000010890 UniProtKB/TrEMBL
  ENSSSCP00000039536 UniProtKB/TrEMBL
  ENSSSCP00000044214 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCP00000068701 UniProtKB/TrEMBL
  ENSSSCP00000071051 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000011180 UniProtKB/TrEMBL
  ENSSSCT00000050632 ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCT00000065464 UniProtKB/TrEMBL
  ENSSSCT00000073736 UniProtKB/TrEMBL
  ENSSSCT00000077530 UniProtKB/TrEMBL
InterPro Kinase-like_dom_sf UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/TrEMBL
  Ser/Thr_kinase_AS UniProtKB/TrEMBL
KEGG Report ssc:100155762 UniProtKB/TrEMBL
NCBI Gene CDK1 ENTREZGENE
Pfam Pkinase UniProtKB/TrEMBL
PROSITE PROTEIN_KINASE_ATP UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/TrEMBL
  PROTEIN_KINASE_ST UniProtKB/TrEMBL
SMART S_TKc UniProtKB/TrEMBL
Superfamily-SCOP SSF56112 UniProtKB/TrEMBL
UniProt A0A287A6N5_PIG UniProtKB/TrEMBL
  A0A5G2QUR4_PIG UniProtKB/TrEMBL
  A0A5G2R1J5_PIG UniProtKB/TrEMBL
  C0SW08 ENTREZGENE, UniProtKB/TrEMBL
  F6PRR7_PIG UniProtKB/TrEMBL
VGNC ID VGNC:103917 ENTREZGENE