Unc5b (unc-5 netrin receptor B) - Rat Genome Database

Name: Unc5b
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

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Gene: Unc5b (unc-5 netrin receptor B) Rattus norvegicus

Analyze

Symbol:

Unc5b

Name:

unc-5 netrin receptor B

RGD ID:

621756

Description:

Exhibits netrin receptor activity. Involved in axon guidance and positive regulation of extrinsic apoptotic signaling pathway in absence of ligand. Localizes to membrane raft. Orthologous to human UNC5B (unc-5 netrin receptor B); INTERACTS WITH (+)-schisandrin B; 1-naphthyl isothiocyanate; 2,3,7,8-tetrachlorodibenzodioxine.

Type:

protein-coding

RefSeq Status:

VALIDATED

Also known as:

netrin receptor UNC5B; transmembrane receptor Unc5H2; unc-5 homolog 2; unc-5 homolog B; unc-5 homolog B (C. elegans); Unc5h2

RGD Orthologs

Human

Mouse

Chinchilla

Bonobo

Dog

Squirrel

Pig

Green Monkey

Naked Mole-Rat

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	UNC5B (unc-5 netrin receptor B)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, Treefam
Mus musculus (house mouse):	Unc5b (unc-5 netrin receptor B)	HGNC	Treefam, EggNOG, OrthoMCL, NCBI, OMA, HomoloGene, Inparanoid, Panther, OrthoDB, Ensembl
Chinchilla lanigera (long-tailed chinchilla):	Unc5b (unc-5 netrin receptor B)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	UNC5B (unc-5 netrin receptor B)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	UNC5B (unc-5 netrin receptor B)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Unc5b (unc-5 netrin receptor B)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	UNC5B (unc-5 netrin receptor B)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (African green monkey):	UNC5B (unc-5 netrin receptor B)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Unc5b (unc-5 netrin receptor B)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Mus musculus (house mouse):	Unc5b (unc-5 netrin receptor B)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|TreeFam)
Homo sapiens (human):	UNC5B (unc-5 netrin receptor B)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|TreeFam)
Caenorhabditis elegans (roundworm):	unc-5	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|TreeFam)
Drosophila melanogaster (fruit fly):	unc-5	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|TreeFam)

Latest Assembly:

Rnor_6.0 - RGSC Genome Assembly v6.0

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rnor_6.0	20	30,339,680 - 30,406,593 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	20	30,339,673 - 30,406,295 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	20	32,148,315 - 32,215,391 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	20	28,095,243 - 28,162,204 (-)	NCBI	RGSC3.4		rn4	RGSC3.4
RGSC_v3.1	20	28,109,042 - 28,176,004 (-)	NCBI
Celera	20	30,138,282 - 30,201,182 (-)	NCBI		Celera
Cytogenetic Map	20	q11	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Subarachnoid Hemorrhage (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(+)-schisandrin B (EXP)

(S)-nicotine (ISO)

1,1-dichloroethene (ISO)

1-naphthyl isothiocyanate (EXP)

17alpha-ethynylestradiol (ISO)

17beta-estradiol (ISO)

2,2',4,4',5,5'-hexachlorobiphenyl (ISO)

2,2',4,4'-Tetrabromodiphenyl ether (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

4,4'-diaminodiphenylmethane (ISO)

4,4'-sulfonyldiphenol (ISO)

4-hydroxyphenyl retinamide (ISO)

5-fluorouracil (ISO)

6-propyl-2-thiouracil (EXP)

8-Br-cAMP (ISO)

acetamide (EXP)

aflatoxin B1 (EXP,ISO)

aflatoxin B2 (ISO)

all-trans-retinoic acid (ISO)

ammonium chloride (EXP)

amphetamine (EXP)

arsane (ISO)

arsenic atom (ISO)

atrazine (ISO)

benzo[a]pyrene (ISO)

benzo[b]fluoranthene (ISO)

benzo[e]pyrene (ISO)

Benzo[k]fluoranthene (ISO)

bis(2-ethylhexyl) phthalate (EXP,ISO)

bisphenol A (EXP,ISO)

bisphenol F (ISO)

butanal (ISO)

Butylparaben (EXP)

carbamazepine (ISO)

choline (ISO)

clofibric acid (EXP)

copper(II) sulfate (ISO)

cyclosporin A (ISO)

DDE (EXP)

decabromodiphenyl ether (EXP)

dexamethasone (ISO)

dibutyl phthalate (EXP)

dichlorine (EXP)

dichloroacetic acid (ISO)

dieldrin (EXP)

disodium selenite (ISO)

dorsomorphin (ISO)

elemental selenium (ISO)

endosulfan (EXP)

entinostat (ISO)

enzacamene (EXP)

epoxiconazole (EXP)

ethanol (ISO)

fenvalerate (EXP)

folic acid (ISO)

formaldehyde (ISO)

furan (EXP)

hydrogen peroxide (ISO)

hydroquinone (ISO)

indole-3-methanol (EXP)

isotretinoin (ISO)

L-methionine (ISO)

linuron (EXP)

methapyrilene (ISO)

methylmercury chloride (ISO)

N-methyl-4-phenylpyridinium (ISO)

nicotine (ISO)

orphenadrine (EXP)

oxaliplatin (EXP)

ozone (EXP)

paracetamol (ISO)

pentanal (ISO)

perfluorononanoic acid (ISO)

perfluorooctanoic acid (EXP)

phenethyl isothiocyanate (ISO)

phenobarbital (ISO)

pirinixic acid (ISO)

prochloraz (EXP)

procymidone (EXP)

propanal (ISO)

rotenone (ISO)

SB 431542 (ISO)

selenium atom (ISO)

silicon dioxide (ISO)

sunitinib (ISO)

Tesaglitazar (EXP)

tetrachloromethane (EXP)

thioacetamide (EXP)

titanium dioxide (ISO)

topotecan (EXP)

trichloroethene (ISO)

triclosan (ISO)

troglitazone (EXP,ISO)

urethane (ISO)

valproic acid (EXP,ISO)

vinclozolin (EXP)

zinc dichloride (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

anterior/posterior axon guidance (IBA,IEA,ISO)

apoptotic process (IEA)

axon guidance (IBA,IDA,IGI)

negative regulation of extrinsic apoptotic signaling pathway in absence of ligand (IEA,ISO)

negative regulation of neuron apoptotic process (IEA,ISO)

netrin-activated signaling pathway (IEA)

positive regulation of extrinsic apoptotic signaling pathway in absence of ligand (IMP)

positive regulation of phosphatidylinositol 3-kinase signaling (IEA,ISO)

Cellular Component

integral component of membrane (IEA)

membrane raft (IDA)

plasma membrane (IEA,TAS)

Molecular Function

netrin receptor activity (IBA,IDA,IEA)

protein binding (IPI,ISO)

References

References - curated


1.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Guenebeaud C, etal., Mol Cell. 2010 Dec 22;40(6):863-76. doi: 10.1016/j.molcel.2010.11.021.
3.	Leonardo ED, etal., Nature 1997 Apr 24;386(6627):833-8.
4.	MGD data from the GO Consortium
5.	NCBI rat LocusLink and RefSeq merged data July 26, 2002
6.	RGD automated data pipeline
7.	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
8.	RGD automated import pipeline for gene-chemical interactions
9.	Tang X, etal., Nat Cell Biol. 2008 Jun;10(6):698-706. doi: 10.1038/ncb1732. Epub 2008 May 11.
10.	Yamagishi S, etal., EMBO J. 2011 Jun 14;30(14):2920-33. doi: 10.1038/emboj.2011.189.

Additional References at PubMed

PMID:10399920	PMID:11387206	PMID:17825258	PMID:18479186	PMID:20628609	PMID:21820492	PMID:26116534	PMID:27856613

Genomics

Comparative Map Data

Unc5b
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rnor_6.0	20	30,339,680 - 30,406,593 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	20	30,339,673 - 30,406,295 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	20	32,148,315 - 32,215,391 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	20	28,095,243 - 28,162,204 (-)	NCBI	RGSC3.4		rn4	RGSC3.4
RGSC_v3.1	20	28,109,042 - 28,176,004 (-)	NCBI
Celera	20	30,138,282 - 30,201,182 (-)	NCBI		Celera
Cytogenetic Map	20	q11	NCBI

UNC5B
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38.p13 Ensembl	10	71,212,570 - 71,302,864 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh38	10	71,212,535 - 71,302,879 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh37	10	72,972,292 - 73,062,635 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	10	72,642,353 - 72,729,722 (+)	NCBI	NCBI36		hg18	NCBI36
Build 34	10	72,642,354 - 72,729,714	NCBI
Celera	10	66,254,788 - 66,343,547 (+)	NCBI
Cytogenetic Map	10	q22.1	NCBI
HuRef	10	66,966,129 - 67,056,670 (+)	NCBI		HuRef
CHM1_1	10	73,254,992 - 73,345,299 (+)	NCBI		CHM1_1

Unc5b
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	10	60,598,373 - 60,667,360 (-)	NCBI	GRCm39		mm39
GRCm38	10	60,762,594 - 60,831,581 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	10	60,762,593 - 60,831,581 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	10	60,225,343 - 60,294,329 (-)	NCBI	GRCm37		mm9	NCBIm37
MGSCv36	10	60,157,952 - 60,226,938 (-)	NCBI			mm8
Celera	10	61,863,405 - 61,932,538 (-)	NCBI		Celera
Cytogenetic Map	10	B4	NCBI
cM Map	10	31.52	NCBI

Unc5b
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955437	20,120,946 - 20,199,877 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955437	20,120,996 - 20,199,877 (-)	NCBI	ChiLan1.0	ChiLan1.0

UNC5B
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
PanPan1.1	10	70,207,998 - 70,298,038 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	10	70,207,998 - 70,298,038 (+)	Ensembl	panpan1.1		panPan2
Mhudiblu_PPA_v0	10	67,682,415 - 67,772,760 (+)	NCBI	Mhudiblu_PPA_v0		panPan3

UNC5B
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1 Ensembl	4	22,003,131 - 22,081,744 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
CanFam3.1	4	22,003,131 - 22,084,107 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1

Unc5b
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
SpeTri2.0	NW_004936521	7,472,788 - 7,547,408 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

UNC5B
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	14	74,120,050 - 74,205,273 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	14	74,120,055 - 74,208,055 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	14	80,011,267 - 80,098,887 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

UNC5B
(Chlorocebus sabaeus - African green monkey)

Vervet Assembly	Chr	Position (strand)	Source	Genome Browsers
Vervet Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	9	59,995,997 - 60,086,663 (-)	NCBI

Unc5b
(Heterocephalus glaber - naked mole-rat)

Molerat Assembly	Chr	Position (strand)	Source	Genome Browsers
Molerat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla 1.0	NW_004624754	5,204,875 - 5,280,479 (+)	NCBI

Position Markers

Unc5h2

Rat Assembly	Chr	Position (strand)	Source	JBrowse
Rnor_6.0	20	30,349,728 - 30,349,751	NCBI	Rnor6.0
Rnor_5.0	20	32,158,510 - 32,158,533	UniSTS	Rnor5.0
RGSC_v3.4	20	28,105,734 - 28,105,757	UniSTS	RGSC3.4
Celera	20	30,145,090 - 30,145,113	UniSTS
Cytogenetic Map	20	q11	UniSTS

D7S512

Rat Assembly	Chr	Position (strand)	Source	JBrowse
Rnor_6.0	20	30,370,045 - 30,371,229	NCBI	Rnor6.0
Rnor_5.0	20	32,178,827 - 32,180,011	UniSTS	Rnor5.0
RGSC_v3.4	20	28,126,051 - 28,127,235	UniSTS	RGSC3.4
Celera	20	30,164,947 - 30,166,131	UniSTS
Cytogenetic Map	20	q11	UniSTS

QTLs in Region (Rnor_6.0)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
6893685	Bw111	Body weight QTL 111	2.7	0.004	body mass (VT:0001259)	body weight (CMO:0000012)	20	1	33300419	Rat
9590252	Scort12	Serum corticosterone level QTL 12	20.46	0.001	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	20	1	37550487	Rat
7411668	Foco32	Food consumption QTL 32	8	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	20	1	37550487	Rat
2305926	Iddm37	Insulin dependent diabetes mellitus QTL 37	6		blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	20	2018654	47018654	Rat
1641915	Colcr9	Colorectal carcinoma resistance QTL 9	2.97	0.0024	intestine integrity trait (VT:0010554)	benign colorectal tumor number (CMO:0001795)	20	2999707	47999707	Rat
1598816	Memor12	Memory QTL 12	2.4		exploratory behavior trait (VT:0010471)	average horizontal distance in proximity to the target during voluntary locomotion in an experimental apparatus (CMO:0002674)	20	4108956	49108956	Rat
4889870	Pur30	Proteinuria QTL 30	19	0.005	total urine protein amount (VT:0000032)	urine total protein excretion rate (CMO:0000756)	20	8654341	30991290	Rat
9590092	Insglur9	Insulin/glucose ratio QTL 9	18.38	0.001	blood insulin amount (VT:0001560)	calculated plasma insulin level (CMO:0002170)	20	13834309	56205956	Rat
7411652	Foco24	Food consumption QTL 24		0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	20	13834309	56205956	Rat
2317880	Alcrsp25	Alcohol response QTL 25	2.3		response to alcohol trait (VT:0010489)	duration of loss of righting reflex (CMO:0002289)	20	17827096	56205956	Rat
4889610	Pancm3	Pancreatic morphology QTL 3	3.75	0.001	pancreas mass (VT:0010144)	pancreas wet weight (CMO:0000626)	20	18872150	49108956	Rat
2303626	Vencon10	Ventilatory control QTL 10		0.001	respiration trait (VT:0001943)	respiration rate (CMO:0000289)	20	20858470	56205956	Rat
2303578	Gluco50	Glucose level QTL 50	2		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	20	26608843	56205956	Rat
2303587	Bw93	Body weight QTL 93	13		body mass (VT:0001259)	body weight (CMO:0000012)	20	26608843	56205956	Rat
2300188	Bmd68	Bone mineral density QTL 68	6.4	0.0001	femur mineral mass (VT:0010011)	volumetric bone mineral density (CMO:0001553)	20	26608843	56205956	Rat
1331747	Hrtrt16	Heart rate QTL 16	3.163		heart pumping trait (VT:2000009)	heart rate (CMO:0000002)	20	26712323	56205956	Rat

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	56
Count of miRNA genes:	51
Interacting mature miRNAs:	56
Transcripts:	ENSRNOT00000038537
Prediction methods:	Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium	3	32	4	4	2	4			53	22	28	11
Low		11	43	27	17	27	8	11	21	13	12		8
Below cutoff			10	10		10					1

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_022207	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006256423	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AABR07044983	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AABR07044984	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AABR07044985	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AAHX01100932	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AAHX01100933	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AAHX01100934	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AAHX01100935	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AAHX01100936	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AAHX01100937	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AAHX01100938	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH474016	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	U87306	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Reference Sequences

RefSeq Acc Id:

ENSRNOT00000038537 ⟹ ENSRNOP00000034951

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0 Ensembl	20	30,339,673 - 30,406,295 (-)	Ensembl

RefSeq Acc Id:

NM_022207 ⟹ NP_071543

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	20	30,342,351 - 30,406,197 (-)	NCBI
Rnor_5.0	20	32,148,315 - 32,215,391 (-)	NCBI
RGSC_v3.4	20	28,095,243 - 28,162,204 (-)	RGD
Celera	20	30,138,282 - 30,201,182 (-)	RGD

Sequence:

show sequence

ATGAGGGCCCGGAGCGGGGCGCGGGGCGCGCTGCTGCTGGCGCTGCTGCTCTGCTGGGATCCGA
CACCGAGCTTAGCAGGCATTGACTCTGGTGGCCAGGCACTCCCAGACTCCTTCCCATCAGCACC
CGCGGAGCAGCTGCCTCACTTCCTGCTGGAACCAGAGGATGCCTACATCGTAAAGAACAAGCCA
GTGGAATTGCACTGCCGAGCCTTCCCTGCCACACAGATCTACTTCAAGTGTAATGGCGAGTGGG
TTAGCCAGAAAGGCCACGTCACGCAGGAGAGCCTGGATGAGGCCACAGGCTTGCGAATACGAGA
GGTGCAGATAGAGGTGTCGCGGCAGCAGGTGGAGGAACTTTTTGGGCTCGAGGACTACTGGTGT
CAGTGCGTGGCCTGGAGCTCTTCGGGAACCACCAAGAGTCGCCGAGCCTACATCCGCATTGCCT
ACTTGCGCAAGAACTTTGACCAGGAGCCTCTGGCGAAGGAGGTACCCTTGGATCATGAGGTCCT
TCTGCAGTGCCGCCCACCAGAGGGAGTGCCTGTGGCTGAGGTGGAATGGCTCAAGAATGAAGAT
GTCATCGATCCCGCTCAGGACACTAACTTCCTGCTCACCATTGACCACAACCTCATCATCCGCC
AGGCGCGCCTCTCAGACACAGCCAACTACACCTGTGTGGCAAAGAATATTGTGGCCAAGCGCCG
GAGCACGACGGCCACAGTCATCGTCTATGTGAACGGAGGTTGGTCCAGCTGGGCAGAATGGTCA
CCCTGCTCTAACCGCTGCGGCCGAGGTTGGCAGAAACGTACTAGGACCTGCACCAACCCAGCCC
CACTCAATGGAGGTGCCTTCTGCGAGGGACAGGCTTGCCAGAAGACGGCTTGCACCACCGTGTG
CCCAGTGGATGGAGCGTGGACTGAGTGGAGCAAGTGGTCCGCCTGCAGCACAGAGTGTGCGCAC
TGGCGCAGCCGCGAGTGCATGGCACCGCCGCCCCAGAACGGAGGCCGTGACTGCAGCGGGACGC
TACTTGACTCCAAGAACTGCACCGATGGGCTGTGCGTGCTGAATCAGAGAACTCTAAACGACCC
TAAAAGCCGCCCCCTGGAGCCGTCGGGAGACGTGGCGCTGTATGCGGGCCTCGTGGTGGCCGTC
TTTGTGGTTCTGGCAGTTCTCATGGCTGTAGGAGTGATCGTGTACCGGAGAAACTGCCGGGACT
TCGACACGGACATCACTGACTCCTCTGCTGCCCTCACTGGTGGTTTCCACCCCGTCAACTTCAA
GACTGCAAGGCCCAGCAACCCACAGCTCCTGCACCCATCCGCCCCTCCGGACCTAACGGCCAGT
GCTGGCATCTACCGCGGACCTGTGTATGCCCTGCAGGACTCTGCCGACAAGATCCCTATGACTA
ATTCACCCCTTCTGGATCCCTTGCCCAGCCTCAAGATCAAGGTCTATGACTCCAGCACCATCGG
CTCTGGGGCTGGCCTGGCTGATGGAGCCGACCTGCTGGGTGTCTTACCACCCGGTACATACCCA
GGCGATTTCTCCCGGGACACCCACTTCCTGCACCTGCGCAGCGCCAGCCTTGGTTCCCAGCACC
TCCTGGGCCTCCCTCGAGACCCCAGCAGCAGTGTCAGTGGCACCTTTGGTTGCCTGGGTGGGAG
GCTGACCATTCCCGGCACAGGGGTCAGCCTGTTGGTACCAAATGGAGCCATTCCCCAGGGCAAG
TTCTATGACTTGTATCTACGTATCAACAAGACTGAAAGCACCCTCCCACTTTCGGAAGGTTCCC
AGACAGTATTGAGCCCCTCGGTGACCTGCGGGCCCACGGGCCTCCTCCTGTGCCGCCCTGTTGT
CCTCACTGTGCCCCACTGTGCTGAAGTCATTGCCGGAGACTGGATCTTCCAGCTCAAGACCCAG
GCCCATCAGGGCCACTGGGAGGAGGTGGTGACTTTGGATGAGGAGACTCTGAACACCCCCTGCT
ACTGCCAGCTAGAGGCTAAATCCTGCCACATCCTGTTGGACCAGCTGGGTACCTACGTGTTCAC
GGGCGAGTCCTACTCCCGCTCCGCAGTCAAGCGGCTCCAGCTAGCCATCTTCGCCCCAGCCCTC
TGCACCTCCCTGGAGTATAGTCTCAGGGTCTACTGTCTGGAGGACACTCCTGCAGCACTGAAGG
AGGTCCTAGAGCTGGAGAGGACTCTGGGTGGCTACTTGGTGGAGGAGCCCAAGACTTTGCTCTT
TAAGGACAGTTACCACAACCTACGNCTCTCCCTCCATGACATCCCCCATGCCCACTGGAGGAGC
AAACTACTGGCCAAGTACCAGGAGATTCCCTTCTACCATGTGTGGAACGGCAGCCAGAAAGCCC
TGCACTGCACTTTCACCCTGGAGAGACATAGCCTAGCCTCCACTGAGTTCACCTGTAAGGTCTG
CGTGCGGCAGGTAGAAGGGGAAGGCCAGATTTTCCAGCTGCACACCACGCTGGCTGAGACGCCT
GCTGGCTCCCTGGATGCACTCTGCTCTGCCCCTGGCAATGCTGCCACCACACAGCTGGGACCCT
ATGCCTTCAAGATACCACTGTCCATCCGCCAGAAGATCTGCAACAGCCTGGACGCCCCCAACTC
ACGGGGCAATGACTGGCGGCTGTTGGCACAGAAGCTCTCCATGGACCGGTACCTGAACTACTTC
GCCACCAAAGCTAGTCCCACAGGCGTGATCTTAGACCTCTGGGAAGCTCGGCAGCAGGATGATG
GGGACCTCAACAGCCTGGCCAGTGCCTTGGAGGAGATGGGCAAGAGTGAGATGCTGGTAGCCAT
GACCACTGATGGCGATTGCTGA

hide sequence

RefSeq Acc Id:

XM_006256423 ⟹ XP_006256485

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	20	30,339,680 - 30,406,593 (-)	NCBI
Rnor_5.0	20	32,148,315 - 32,215,391 (-)	NCBI

Sequence:

show sequence

CGGGCGAAGGTGCCGAGCCGCGGGGAGCGGCAGGGCGCGGAGGGGAGCGCACACCCCACTTGGA
CAGACTTTGCGGCGCGGCCGCTGCGAGCGCCACTGAGCGCACTCCACTGGGATCGCGCAACTTC
GGAGCAGGGCGCGGACGGCGGTCGCCGCCGGAGAGCGCGGAAAGGGCGCACCAGAGCCGGGTTC
CCCAGCGGCGTCCACTCCCGGAGCGCTCCGAGCCTCCGGGCAGTCTCCCGGCGCTGCGTGGTTG
CCGCTGCGCCCACGGAGGGCACGGGCTGGCGCTGCCGGGCGCCTGCGAGGACGGCGAGGCGGCG
GCGAAGGCGAAGGCGGCGAGGCTGGGGACCGGGAAAGAACCCCGAGGGAGAGGCGCCCGGGCCG
GGCGACAGGAGCATGAGGGCCCGGAGCGGGGCGCGGGGCGCGCTGCTGCTGCTGGCGCTGCTGC
TCTGCTGGGATCCGACACCGAGCTTAGCAGGCATTGACTCTGGTGGCCAGGCACTCCCAGACTC
CTTCCCATCAGCACCCGCGGAGCAGCTGCCTCACTTCCTGCTGGAACCAGAGGATGCCTACATC
GTAAAGAACAAGCCAGTGGAATTGCACTGCCGAGCCTTCCCTGCCACACAGATCTACTTCAAGT
GTAATGGCGAGTGGGTTAGCCAGAAAGGCCACGTCACGCAGGAGAGCCTGGATGAGGCCACAGG
CTTGCGAATACGAGAGGTGCAGATAGAGGTGTCGCGGCAGCAGGTGGAGGAACTCTTTGGGCTC
GAGGACTACTGGTGTCAGTGCGTGGCCTGGAGCTCTTCGGGAACCACCAAGAGTCGCCGAGCCT
ACATCCGCATTGCCTACTTGCGCAAGAACTTTGACCAGGAGCCTCTGGCGAAGGAGGTACCCTT
GGATCATGAGGTCCTTCTGCAGTGCCGCCCACCAGAGGGAGTGCCTGTGGCTGAGGTGGAATGG
CTCAAGAATGAAGATGTCATCGATCCCGCTCAGGACACTAACTTCCTGCTCACCATTGACCACA
ACCTCATCATCCGCCAGGCGCGCCTCTCAGACACAGCCAACTACACCTGTGTGGCCAAGAATAT
TGTGGCCAAGCGCCGGAGCACGACGGCCACAGTCATCGTCTATGTGAACGGAGGTTGGTCCAGC
TGGGCAGAATGGTCACCCTGCTCTAACCGCTGCGGCCGAGGTTGGCAGAAACGTACTAGGACCT
GCACCAACCCAGCCCCACTCAATGGAGGTGCCTTCTGCGAGGGACAGGCTTTCCAGAAGACGGC
TTGCACCACCGTGTGCCCAGTGGATGGAGCGTGGACTGAGTGGAGCAAGTGGTCCGCCTGCAGC
ACAGAGTGTGCGCACTGGCGCAGCCGCGAGTGCATGGCACCGCCGCCCCAGAACGGAGGCCGCG
ACTGCAGCGGGACGCTACTTGACTCCAAGAACTGCACCGATGGGCTGTGCGTGCTGACCCTGGA
GCCGTCGGGAGACGTGGCGCTGTATGCGGGCCTCGTGGTGGCCGTCTTTGTGGTTCTGGCAGTT
CTCATGGCTGTAGGAGTGATCGTGTACCGGAGAAACTGCCGGGACTTCGACACGGACATCACTG
ACTCCTCTGCTGCCCTCACTGGTGGTTTCCACCCCGTCAACTTCAAGACTGCAAGGCCCAGCAA
CCCACAGCTCCTGCACCCATCCGCCCCTCCGGACCTAACGGCCAGTGCTGGCATCTACCGCGGA
CCTGTGTATGCCCTGCAGGACTCCGCCGACAAGATCCCTATGACTAATTCACCCCTGCTGGATC
CCTTGCCCAGCCTCAAGATCAAGGTCTATGACTCCAGCACCATCGGCTCTGGGGCTGGCCTGGC
TGATGGAGCCGACCTGCTGGGTGTCTTACCACCCGGTACATACCCAGGCGATTTCTCCCGGGAC
ACCCACTTCCTGCACCTGCGCAGCGCCAGCCTCGGTTCCCAGCACCTCCTGGGCCTCCCTCGAG
ACCCCAGCAGCAGTGTCAGTGGCACCTTTGGTTGCCTGGGTGGGAGGCTGACCATTCCCGGCAC
AGGGGTCAGCCTGTTGGTACCAAATGGAGCCATTCCCCAGGGCAAGTTCTATGACTTGTATCTA
CGTATCAACAAGACTGAAAGCACCCTCCCACTTTCAGAAGGTTCCCAGACAGTATTGAGCCCCT
CGGTGACCTGCGGGCCCACGGGCCTCCTCCTGTGCCGCCCTGTTGTCCTCACTGTGCCCCACTG
TGCTGAAGTCATTGCCGGAGACTGGATCTTCCAGCTCAAGACCCAGGCCCATCAGGGCCACTGG
GAGGAGGTGGTGACTTTGGATGAGGAGACTCTGAACACCCCCTGCTACTGCCAGCTAGAGGCTA
AATCCTGCCACATCCTGTTGGACCAGCTGGGTACCTACGTGTTCACGGGCGAGTCCTACTCCCG
CTCCGCAGTCAAGCGGCTCCAGCTAGCCATCTTCGCCCCAGCCCTCTGCACCTCCCTGGAGTAT
AGTCTCAGGGTCTACTGTCTGGAGGACACTCCTGCAGCACTGAAGGAGGTCCTAGAACTGGAGA
GGACTCTGGGTGGCTACTTGGTGGAGGAGCCCAAGCCTTTGCTCTTTAAGGACAGTTACCACAA
CCTACGCCTCTCCCTCCATGACATCCCCCATGCCCACTGGAGGAGCAAACTACTGGCCAAGTAC
CAGGAGATTCCCTTCTACCATGTGTGGAACGGCAGCCAGAAAGCCCTGCACTGCACTTTCACCC
TGGAGAGACATAGCCTAGCCTCCACTGAGTTCACCTGTAAGGTCTGCGTGCGGCAGGTAGAAGG
GGAAGGCCAGATTTTCCAGCTGCACACCACGCTGGCTGAGACGCCTGCTGGCTCCCTGGATGCA
CTCTGCTCTGCCCCTGGCAATGCTGCCACCACACAGCTGGGACCCTATGCCTTCAAGATACCAC
TGTCCATCCGCCAGAAGATCTGCAACAGCCTGGACGCCCCCAACTCACGGGGCAATGACTGGCG
GCTGTTGGCACAGAAGCTCTCCATGGACCGGTACCTGAACTACTTCGCCACCAAAGCTAGTCCC
ACAGGCGTGATCTTAGACCTCTGGGAAGCTCGGCAGCAGGATGATGGGGACCTCAACAGCCTGG
CCAGTGCCTTGGAGGAGATGGGCAAGAGTGAGATGCTGGTAGCCATGACCACTGATGGCGATTG
CTGAGTGCCTGTGACCTCAGGCCTGTGGGGGCCAGTAGGAGATGGTGCAAGGAGGCCTGGCAAC
CTCTCTGTGGGGGTGTCCAACCTCCACCATCCCTGGCTCACAGCTGGAATGGTCCCTCACGCCC
CTCCCCACCACAACCCTCAGACCACCACCAGCCTTAGAAAGACTCTGTGCTCTACTGCCAGGAG
GCGGGGATCCTCGGCCTCACCGTTTCCCCAGCTCACTCTGGGGTGGGCTGAGTCCTCGGGGGCA
GCTGAAGGCCAGAGGCTTTCCCCCCACAACACACCACCCTCAGCCCTGTGACTTTGGAGGCCCA
CGGGTTTCAGTTCTGTGTTCACATGGTCCTCGGCTAAGGACTGCTCTCCTATCCCGGGTCCTCT
CTGAAAGGTCAAGTTCAGTTCAAGCAAACTGCTCGCTTTCTCCTGCCCACAAACTTAGAGAGAG
AGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAGAATATGAGCCTCAGAA
GTCAGCGAGACTCGGGCAATGATAGTGCAAAAACTATAAGGGCAAAGAAACCCAGTTTCTTAGG
GAACGAAAATGATTTATCATCCAGATACCTGGATAGGTCCTTTTTAAGAAAACAAACAAACAAA
CAAAAAAGTAAGGAAAGAAAAAAAAACTTTTATCCTTGAATGTGGTTAAGAGTGGCTGTGCTTG
TGGTTTGGGCCATAGGCAAGTGCATTCTCGGGCACACGTGTGCATGGGTGTGGTCAGCAAGAGA
CTGCACAGGGGAATACTTTGCTGTGGCAAGACCTCAGTGTCCCTAGCTGTGCAGGGAGCTGAGA
CAGGGTTTTAGCCATGACACCAAGTGCTAAACTCTTGAGCAGAGGCTGGCCTGGTGGTCCTCCC
ACTCTCTGTGCTCTTCTGTGGCCTCCTCTAGTTTTGGGGAACCCAAATGGAGGCCCAGGCCAGC
TGTGATGGGGGAGACTGTTCAGGTCTGTTTTACTTTGGTGATTCCTGGTCTAGTGATGGCCAAG
GGTGTGGCTCTTACTGAGAGGGAGGGGCTATTCCAGGGATGGTTCCCTCCCAGGTTGGATGGCT
TTGTGTCTAGGCTGGTACTAGCCAGTCCGCACCCTGTTTACCCACTCATCTTCCTTCTTGGAGT
CAGGAGCTGTGAAGGTAACTTTTCCACCCACCTTTGGCCACAGCCCATTCTGGGATGTTCCACA
GGGCCACAGTAGAAGGGATGAATTCTTGTCCCTTCAGCCCACGGGCAGTGATGGAGACCAGGAC
CTCACTGTAGACATAGAGATCCTATCGAAGGATACTTACTGTAGAATCAAGACTTGCTGTAAAA
CTTCCCTGAACTCCCATTGAGACCACCCTGGCAGGTCCTGAGCTTTGAAAGTTGGGGCCTCTGT
GGGGAGGCAGGTTTCATGGCCACAGACCCAGCGAGCGTCTGTGCCCTGGGTTTCCGCAGTGGCT
CCTGAAGTGGGACTCTAAGACTGAGACCGAGGTGCTCCTGGCATCTAGGTGAATGGTGCCTCAT
AGAGTGTCCTCAGCTCCTCCTGCCAAAGATGCTCATCCCCGTGGGCATACTCTTGCTGGTCACT
GTTAGCCCGCACATAGAAATGGGAAGCCCGGGAACCAAGTTGTAGCTATGCTGTGTGACTTCAG
GCACATAACCGCTTTCTCTGGGCTTAAGTGTCCTTTTATCCTGGGATGCTCCACGAGGCCCCTT
AGGTTCCCACACTCCTCTGGGACTCTAGTAGAGACAAGTTGATTGTGGTCTGCATTTGCCCATC
CTCAGAAACCTGCCTGTCTGGGCCCTGGTGGGAGCACGTAGGGAGCGAGTCCCAGTTTACGGTC
TGACTCTTGGGAGGTGCTCAGCATCTGGAGCACAAAGGCTGGAGCTGGAGCCTGGGGCAGGGCT
CCAACCTCATAGTTTGGTAGCAGCCGCCCGGGGAATGTCGGCCAACTCTGGGCAGAGCCAGGCA
GGGCTATTGGGTTGGGTTTCCACTCCTGCCTCCAATGAGATGGCACCTCCCCTTCCCATTCCTG
GCCAGCTTGGTGTTGCCGGGTCCTGCAGGGTATTTCTGTGTCATCGTGTGTGTGTGTGTGTGTG
TGTGTGTGTGTGTGTGTGTGTGTGTGCGCGCGCACGCGCGCGCGTGCGTGCTTGCCTGTGTTTT
TCAACTTGGGCACATCAGGGCACCCCTCCTAGAACGCACACACTTGTCCCCACACGTGGACATG
ACCTCTGTGCCCAGGCTCGTGCCACTGAGGAGGACATGCCTGTTTGCTGTCCCAAGTCAGTCAG
TCCGTGTATCTCCTAATGTGCCTCTCCTGCCCTTCCTCAGGGGGCTCCAGGCTTCTGCGCTCTG
GCTAGACACCTCCTGAGGGACAGAGACCCTCCTCATCCCTGGATCTGCCAGGGCTCTCTGGTCC
CCATCTTGAGGCTCCCAGGCATCTGAGTCAGCACCTTCCTCCCGCCCTCAGAGGTCGGGTGTGT
GGGAGCTTGGATGTCAGGCTGTGAACATGGCTGTGTGTCTGTGGGTTCTGATCCACTGGGGATA
GTCCCAGCCCCACCCGTTCATTCTGTAAACAACTTGTAAATAACCTTTAGCATTCCTCTTGTAA
CAAAATTAATTTTTATGAAATAAATTATATTTCCTAGTCTATAAAAAAAAA

hide sequence

Protein Sequences


Protein RefSeqs	NP_071543	(Get FASTA)	NCBI Sequence Viewer
	XP_006256485	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAB57679	(Get FASTA)	NCBI Sequence Viewer
	EDL93040	(Get FASTA)	NCBI Sequence Viewer
	O08722	(Get FASTA)	NCBI Sequence Viewer

Reference Sequences

RefSeq Acc Id:

NP_071543 ⟸ NM_022207

- Peptide Label:

precursor

- Sequence:

show sequence

MRARSGARGALLLALLLCWDPTPSLAGIDSGGQALPDSFPSAPAEQLPHFLLEPEDAYIVKNKP
VELHCRAFPATQIYFKCNGEWVSQKGHVTQESLDEATGLRIREVQIEVSRQQVEELFGLEDYWC
QCVAWSSSGTTKSRRAYIRIAYLRKNFDQEPLAKEVPLDHEVLLQCRPPEGVPVAEVEWLKNED
VIDPAQDTNFLLTIDHNLIIRQARLSDTANYTCVAKNIVAKRRSTTATVIVYVNGGWSSWAEWS
PCSNRCGRGWQKRTRTCTNPAPLNGGAFCEGQACQKTACTTVCPVDGAWTEWSKWSACSTECAH
WRSRECMAPPPQNGGRDCSGTLLDSKNCTDGLCVLNQRTLNDPKSRPLEPSGDVALYAGLVVAV
FVVLAVLMAVGVIVYRRNCRDFDTDITDSSAALTGGFHPVNFKTARPSNPQLLHPSAPPDLTAS
AGIYRGPVYALQDSADKIPMTNSPLLDPLPSLKIKVYDSSTIGSGAGLADGADLLGVLPPGTYP
GDFSRDTHFLHLRSASLGSQHLLGLPRDPSSSVSGTFGCLGGRLTIPGTGVSLLVPNGAIPQGK
FYDLYLRINKTESTLPLSEGSQTVLSPSVTCGPTGLLLCRPVVLTVPHCAEVIAGDWIFQLKTQ
AHQGHWEEVVTLDEETLNTPCYCQLEAKSCHILLDQLGTYVFTGESYSRSAVKRLQLAIFAPAL
CTSLEYSLRVYCLEDTPAALKEVLELERTLGGYLVEEPKTLLFKDSYHNLRLSLHDIPHAHWRS
KLLAKYQEIPFYHVWNGSQKALHCTFTLERHSLASTEFTCKVCVRQVEGEGQIFQLHTTLAETP
AGSLDALCSAPGNAATTQLGPYAFKIPLSIRQKICNSLDAPNSRGNDWRLLAQKLSMDRYLNYF
ATKASPTGVILDLWEARQQDDGDLNSLASALEEMGKSEMLVAMTTDGDC

hide sequence

RefSeq Acc Id:

XP_006256485 ⟸ XM_006256423

- Peptide Label:

isoform X1

- Sequence:

show sequence

MRARSGARGALLLLALLLCWDPTPSLAGIDSGGQALPDSFPSAPAEQLPHFLLEPEDAYIVKNK
PVELHCRAFPATQIYFKCNGEWVSQKGHVTQESLDEATGLRIREVQIEVSRQQVEELFGLEDYW
CQCVAWSSSGTTKSRRAYIRIAYLRKNFDQEPLAKEVPLDHEVLLQCRPPEGVPVAEVEWLKNE
DVIDPAQDTNFLLTIDHNLIIRQARLSDTANYTCVAKNIVAKRRSTTATVIVYVNGGWSSWAEW
SPCSNRCGRGWQKRTRTCTNPAPLNGGAFCEGQAFQKTACTTVCPVDGAWTEWSKWSACSTECA
HWRSRECMAPPPQNGGRDCSGTLLDSKNCTDGLCVLTLEPSGDVALYAGLVVAVFVVLAVLMAV
GVIVYRRNCRDFDTDITDSSAALTGGFHPVNFKTARPSNPQLLHPSAPPDLTASAGIYRGPVYA
LQDSADKIPMTNSPLLDPLPSLKIKVYDSSTIGSGAGLADGADLLGVLPPGTYPGDFSRDTHFL
HLRSASLGSQHLLGLPRDPSSSVSGTFGCLGGRLTIPGTGVSLLVPNGAIPQGKFYDLYLRINK
TESTLPLSEGSQTVLSPSVTCGPTGLLLCRPVVLTVPHCAEVIAGDWIFQLKTQAHQGHWEEVV
TLDEETLNTPCYCQLEAKSCHILLDQLGTYVFTGESYSRSAVKRLQLAIFAPALCTSLEYSLRV
YCLEDTPAALKEVLELERTLGGYLVEEPKPLLFKDSYHNLRLSLHDIPHAHWRSKLLAKYQEIP
FYHVWNGSQKALHCTFTLERHSLASTEFTCKVCVRQVEGEGQIFQLHTTLAETPAGSLDALCSA
PGNAATTQLGPYAFKIPLSIRQKICNSLDAPNSRGNDWRLLAQKLSMDRYLNYFATKASPTGVI
LDLWEARQQDDGDLNSLASALEEMGKSEMLVAMTTDGDC

hide sequence

RefSeq Acc Id:

ENSRNOP00000034951 ⟸ ENSRNOT00000038537

Protein Domains

Death Ig-like Ig-like C2-type TSP type-1 ZU5

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Strain Variation

Strain Sequence Variants (Rnor 6.0)

ACI/EurMcwi (MCW)

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CSV

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

ACI/EurMcwi (RGD)

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CSV

TAB

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

ACI/N (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

BBDP/Wor (RGD)

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CSV

TAB

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

BN/SsN (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Buf/N (MCW)

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CSV

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

COP/CrCrl (MCW & UW)

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CSV

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob) University of Wisconsin (Dr. James Shull)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Charles River Laboratories
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)

F344/NCrl (RGD)

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CSV

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

F344/NRrrc (MCW)

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CSV

TAB

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

FHH/EurMcwi (MCW)

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CSV

TAB

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

FHH/EurMcwi (RGD)

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CSV

TAB

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

FHL/EurMcwi (MCW)

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CSV

TAB

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

FHL/EurMcwi (RGD)

Visual

CSV

TAB

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

GH/OmrMcwi (MCW)

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CSV

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

GK/Ox (RGD)

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CSV

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LE/Stm (RGD)

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CSV

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LEW/Crl (RGD)

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CSV

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LEW/NCrlBR (RGD)

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CSV

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LH/MavRrrc (RGD)

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CSV

TAB

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LL/MavRrrc (RGD)

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CSV

TAB

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LN/MavRrrc (RGD)

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CSV

TAB

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

M520/N (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

MHS/Gib (RGD)

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CSV

TAB

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

MNS/Gib (RGD)

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CSV

TAB

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

MR/N (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

SBH/Ygl (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	SBH/Ygl sequenced by MCW

SBH/Ygl (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SBN/Ygl (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	SBN/Ygl sequenced by MCW

SBN/Ygl (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SHR/NHsd (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SHRSP/Gcrc (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SR/JrHsd (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Harlan Laboratories
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

SR/JrHsd (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SS/Jr (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SS/JrHsdMcwi (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

SS/JrHsdMcwi (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

WAG/Rij (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

WKY/Gcrc (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

WKY/N (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

WKY/NCrl (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

WKY/NHsd (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

WN/N (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Damaging Variants

Assembly: Rnor_5.0

Chromosome	Start Pos	End Pos	Reference Nucleotide	Variant Nucleotide	Variant Type	Strain
20	32167601	32167602	G	T	snv	SR/JrHsd (MCW)

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:621756	AgrOrtholog
Ensembl Genes	ENSRNOG00000000567	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein	ENSRNOP00000034951	ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000038537	ENTREZGENE, UniProtKB/TrEMBL
Gene3D-CATH	2.20.100.10	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	2.60.40.10	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro	DEATH-like_dom_sf	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Death_domain	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Death_UNC5B	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Ig-like_dom	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Ig-like_dom_sf	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Ig-like_fold	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Ig_I-set	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Ig_sub	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Ig_sub2	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	TSP1_rpt	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	TSP1_rpt_sf	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	UNC5	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	UPA	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	ZU5_dom	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report	rno:60630	UniProtKB/Swiss-Prot
NCBI Gene	60630	ENTREZGENE
PANTHER	PTHR12582	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam	Death	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	I-set	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	TSP_1	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	UPA	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	ZU5	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen	Unc5b	PhenoGen
PROSITE	DEATH_DOMAIN	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	IG_LIKE	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	TSP1	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	ZU5	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART	DEATH	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	IGc2	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	SM00409	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	TSP1	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	ZU5	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP	SSF47986	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	SSF48726	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	SSF82895	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniGene	Rn.34617	ENTREZGENE
UniProt	F1LNE2_RAT	UniProtKB/TrEMBL
	O08722	ENTREZGENE, UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2015-06-26	Unc5b	unc-5 netrin receptor B	Unc5b	unc-5 homolog B (C. elegans)	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2004-09-10	Unc5b	unc-5 homolog B (C. elegans)	Unc5h2	transmembrane receptor Unc5H2	Symbol and Name updated	1299863	APPROVED
2002-08-07	Unc5h2	transmembrane receptor Unc5H2			Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - CTD