Cyp21a1 (cytochrome P450, family 21, subfamily a, polypeptide 1) - Rat Genome Database

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Gene: Cyp21a1 (cytochrome P450, family 21, subfamily a, polypeptide 1) Rattus norvegicus
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Symbol: Cyp21a1
Name: cytochrome P450, family 21, subfamily a, polypeptide 1
RGD ID: 2461
Description: Enables steroid 21-monooxygenase activity. Involved in C21-steroid hormone metabolic process; cellular response to peptide hormone stimulus; and mineralocorticoid biosynthetic process. Predicted to be located in endoplasmic reticulum membrane. Human ortholog(s) of this gene implicated in congenital adrenal hyperplasia. Orthologous to several human genes including CYP21A2 (cytochrome P450 family 21 subfamily A member 2); PARTICIPATES IN aldosterone biosynthetic pathway; cortisol biosynthetic pathway; steroid hormone biosynthetic pathway; INTERACTS WITH atorvastatin calcium; bisphenol A; caffeine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 21-OH; 21-OHase; Cyp21; cytochrome P-450c21; cytochrome P450 21 steroid 21 hydroxylase; Cytochrome P450 subfamily XXI (steroid 21-hydroxylase); cytochrome P450 XXI; cytochrome P450, subfamily 21A, polypeptide 1; Cytochrome P450, subfamily XXI (steroid 21-hydroxylase); cytochrome P450-C21; P-450c21; P450-C21; steroid 21-hydroxylase
RGD Orthologs
Human
Alliance Genes
More Info more info ...
Related Pseudogenes: Cyp21a1-ps  
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8204,028,323 - 4,031,549 (+)NCBIGRCr8
mRatBN7.2204,020,217 - 4,026,923 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl204,023,767 - 4,026,923 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx204,723,724 - 4,726,869 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0204,085,473 - 4,088,621 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0204,622,634 - 4,625,791 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0204,486,213 - 4,489,358 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl204,486,219 - 4,489,550 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0206,565,575 - 6,569,291 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4204,125,357 - 4,128,518 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1204,125,583 - 4,128,745 (+)NCBI
Celera204,003,177 - 4,005,586 (-)NCBICelera
Cytogenetic Map20p12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Regulation of cytochrome P4501B1 in cultured rat adrenocortical cells by cyclic adenosine 3',5'-monophosphate and 2,3,7,8- tetrachlorodibenzo-p-dioxin. Brake PB and Jefcoate CR, Endocrinology. 1995 Nov;136(11):5034-41.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Long-term dose-dependent response of Mequindox on aldosterone, corticosterone and five steroidogenic enzyme mRNAs in the adrenal of male rats. Huang XJ, etal., Toxicol Lett. 2009 Dec 15;191(2-3):167-73. Epub 2009 Sep 4.
4. The genomic sequence and comparative analysis of the rat major histocompatibility complex. Hurt P, etal., Genome Res 2004 Apr;14(4):631-9.
5. Steroid 21-hydroxylase expression in cultured rat astrocytes. Lovelace M, etal., Brain Res Bull 2003 Oct 15;61(6):609-15.
6. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
7. Development of relevant assay system to identify steroidogenic enzyme inhibitors. Nishizato Y, etal., Toxicol In Vitro. 2010 Mar;24(2):677-85. Epub 2009 Aug 7.
8. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
9. Overview of steroidogenic enzymes in the pathway from cholesterol to active steroid hormones. Payne AH and Hales DB, Endocr Rev. 2004 Dec;25(6):947-70.
10. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
11. GOA pipeline RGD automated data pipeline
12. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
13. Congenital adrenal hyperplasia. Speiser PW and White PC, N Engl J Med. 2003 Aug 21;349(8):776-88.
14. Cloning of two alternatively spliced 21-hydroxylase CDNAs from rat adrenal. Zhou MY, etal., J Steroid Biochem Mol Biol 1997 Jul;62(4):277-86.
Additional References at PubMed
PMID:12136338  


Genomics

Comparative Map Data
Cyp21a1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8204,028,323 - 4,031,549 (+)NCBIGRCr8
mRatBN7.2204,020,217 - 4,026,923 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl204,023,767 - 4,026,923 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx204,723,724 - 4,726,869 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0204,085,473 - 4,088,621 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0204,622,634 - 4,625,791 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0204,486,213 - 4,489,358 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl204,486,219 - 4,489,550 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0206,565,575 - 6,569,291 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4204,125,357 - 4,128,518 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1204,125,583 - 4,128,745 (+)NCBI
Celera204,003,177 - 4,005,586 (-)NCBICelera
Cytogenetic Map20p12NCBI
CYP21A1P
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38632,005,636 - 32,008,909 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl632,005,689 - 32,008,399 (+)EnsemblGRCh38hg38GRCh38
GRCh37631,973,413 - 31,976,686 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36632,080,697 - 32,084,739 (+)NCBINCBI36Build 36hg18NCBI36
Cytogenetic Map6p21.33NCBI
CHM1_1631,975,666 - 31,978,939 (+)NCBICHM1_1
T2T-CHM13v2.0631,858,842 - 31,862,115 (+)NCBIT2T-CHM13v2.0

Variants

.
Variants in Cyp21a1
17 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:259
Count of miRNA genes:164
Interacting mature miRNAs:178
Transcripts:ENSRNOT00000031548
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1354642Despr15Despair related QTL 150.0027locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)20124159021Rat
1600382Edcs3Endometrial carcinoma susceptibility QTL33.50.003uterus morphology trait (VT:0001120)percentage of study population developing endometrioid carcinoma during a period of time (CMO:0001759)20125159026Rat
2317851Alcrsp22Alcohol response QTL 223.20.05response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)20127339237Rat
1641893Alcrsp7Alcohol response QTL 7response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)20127339237Rat
8694189Bw153Body weight QTL 1533.130.001body mass (VT:0001259)body weight gain (CMO:0000420)20129191651Rat
9590275Scort15Serum corticosterone level QTL 153.480.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)20129191651Rat
7411650Foco23Food consumption QTL 2320.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)20129191651Rat
9590109Sffal8Serum free fatty acids level QTL 85.320.01blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)20129191651Rat
9589155Insul32Insulin level QTL 326.380.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)20129191651Rat
6893685Bw111Body weight QTL 1112.70.004body mass (VT:0001259)body weight (CMO:0000012)20132578807Rat
7411668Foco32Food consumption QTL 3280.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)20136600972Rat
9590252Scort12Serum corticosterone level QTL 1220.460.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)20136600972Rat
2305926Iddm37Insulin dependent diabetes mellitus QTL 376blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)20152784246527842Rat
2306850Pia40Pristane induced arthritis QTL 400.0001joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)2015279595304575Rat
1641915Colcr9Colorectal carcinoma resistance QTL 92.970.0024intestine integrity trait (VT:0010554)benign colorectal tumor number (CMO:0001795)20153065546530655Rat
1598816Memor12Memory QTL 122.4exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)20260683647606836Rat
61448Ciaa1CIA Autoantibody QTL 1300.001blood autoantibody amount (VT:0003725)calculated serum anti-rat type 2 collagen autoantibody titer (CMO:0001281)2026463954597031Rat
61472Aia1Adjuvant induced arthritis QTL 1180.001joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)2026463954597031Rat
2317057Aia27Adjuvant induced arthritis QTL 272.83joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)20289259726381954Rat
1300152Bp195Blood pressure QTL 1953.46arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2036216499243559Rat
1331772Cdexp2CD45RC expression in CD8 T cells QTL 25.7CD8-positive T cell quantity (VT:0008077)blood CD45RC(high) CD8 T cell count to CD45RC(low) CD8 T cell count ratio (CMO:0001990)20362164910078919Rat
737973Pia21Pristane induced arthritis QTL 214.8joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)2036216564606812Rat
61432Cia1Collagen induced arthritis QTL 1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)20362165614101050Rat

Markers in Region
RH94616  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2204,026,509 - 4,026,599 (-)MAPPERmRatBN7.2
Rnor_6.0204,486,543 - 4,486,632NCBIRnor6.0
Rnor_5.0206,565,899 - 6,565,988UniSTSRnor5.0
RGSC_v3.4204,128,105 - 4,128,194UniSTSRGSC3.4
Celera204,003,501 - 4,003,590UniSTS
RH 3.4 Map2052.42UniSTS
Cytogenetic Map20p12UniSTS
RH134814  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2204,026,558 - 4,026,742 (-)MAPPERmRatBN7.2
Rnor_6.0204,486,400 - 4,486,583NCBIRnor6.0
Rnor_5.0206,565,756 - 6,565,939UniSTSRnor5.0
RGSC_v3.4204,128,154 - 4,128,337UniSTSRGSC3.4
Celera204,003,358 - 4,003,541UniSTS
Cytogenetic Map20p12UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High 8 1
Medium 3
Low 2 10 17 9 19 9 8 8 8 15 9 11 8
Below cutoff 1 7 22 22 22 3 29 6 17

Sequence


RefSeq Acc Id: ENSRNOT00000031548   ⟹   ENSRNOP00000037516
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl204,023,767 - 4,026,923 (+)Ensembl
Rnor_6.0 Ensembl204,486,219 - 4,489,281 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000077892
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl204,488,918 - 4,489,550 (-)Ensembl
RefSeq Acc Id: NM_057101   ⟹   NP_476442
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8204,028,391 - 4,031,543 (+)NCBI
mRatBN7.2204,023,767 - 4,026,923 (+)NCBI
Rnor_6.0204,486,219 - 4,489,281 (-)NCBI
Rnor_5.0206,565,575 - 6,569,291 (-)NCBI
RGSC_v3.4204,125,357 - 4,128,518 (+)RGD
Celera204,003,177 - 4,005,586 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006255907   ⟹   XP_006255969
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8204,028,334 - 4,031,549 (+)NCBI
mRatBN7.2204,020,217 - 4,026,487 (+)NCBI
Rnor_6.0204,486,213 - 4,489,358 (-)NCBI
Rnor_5.0206,565,575 - 6,569,291 (-)NCBI
Sequence:
RefSeq Acc Id: XM_063278951   ⟹   XP_063135021
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8204,028,333 - 4,031,549 (+)NCBI
RefSeq Acc Id: XM_063278952   ⟹   XP_063135022
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8204,028,323 - 4,031,549 (+)NCBI
RefSeq Acc Id: NP_476442   ⟸   NM_057101
- UniProtKB: Q64562 (UniProtKB/Swiss-Prot),   F1LRG0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006255969   ⟸   XM_006255907
- Peptide Label: isoform X1
- UniProtKB: Q64562 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSRNOP00000037516   ⟸   ENSRNOT00000031548
RefSeq Acc Id: XP_063135022   ⟸   XM_063278952
- Peptide Label: isoform X3
RefSeq Acc Id: XP_063135021   ⟸   XM_063278951
- Peptide Label: isoform X2

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q64562-F1-model_v2 AlphaFold Q64562 1-493 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13701351
Promoter ID:EPDNEW_R11874
Type:initiation region
Name:Cyp21a1_1
Description:cytochrome P450, family 21, subfamily a, polypeptide 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0204,489,258 - 4,489,318EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2461 AgrOrtholog
BioCyc Gene G2FUF-4596 BioCyc
BioCyc Pathway PWY66-381 [glucocorticoid biosynthesis] BioCyc
  PWY66-382 [mineralocorticoid biosynthesis] BioCyc
BioCyc Pathway Image PWY66-381 BioCyc
  PWY66-382 BioCyc
Ensembl Genes ENSRNOG00000000428 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000031548 ENTREZGENE
  ENSRNOT00000031548.4 UniProtKB/TrEMBL
Gene3D-CATH 1.10.630.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Cyt_P450 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cyt_P450_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cyt_P450_E_grp-I UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cyt_P450_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:24298 UniProtKB/TrEMBL
NCBI Gene 24298 ENTREZGENE
PANTHER STEROID 17-ALPHA-HYDROXYLASE/17,20 LYASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  STEROID 21-HYDROXYLASE-LIKE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam p450 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Cyp21a1 PhenoGen
PRINTS EP450I UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  P450 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE CYTOCHROME_P450 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000000428 RatGTEx
Superfamily-SCOP SSF48264 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A6KTJ7_RAT UniProtKB/TrEMBL
  CP21A_RAT UniProtKB/Swiss-Prot
  F1LRG0 ENTREZGENE, UniProtKB/TrEMBL
  Q64562 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2010-04-19 Cyp21a1  cytochrome P450, family 21, subfamily a, polypeptide 1  Cyp21a1  cytochrome P450, subfamily 21A, polypeptide 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-11-06 Cyp21a1  cytochrome P450, subfamily 21A, polypeptide 1  Cyp21  Cytochrome P450, subfamily XXI (steroid 21-hydroxylase)  Symbol and Name updated 625702 APPROVED
2002-06-10 Cyp21  Cytochrome P450, subfamily XXI (steroid 21-hydroxylase)      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression expressed in kidney, aorta, liver, cerebellum, hypothalamus and brain stem, heart and cerebrum, but not in hippocampus 1298842
gene_expression expressed in astrocytes 1298841
gene_function converts progesterone to deoxycorticosterone 1298842
gene_function performs 21-hydroxylation of steroids in astrocytes and CNS 1298842
gene_mapping maps to the MHC RT1 complex 1300431
gene_process metabolizes to tetrahydrodeoxycorticosterone (THDOC), which binds to GABA receptors 1298841