17alpha-ethynylestradiol multiple interactions ISO RGD:1550173 6480464 [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of EHMT2 mRNA CTD PMID:17942748 17alpha-ethynylestradiol increases expression ISO RGD:1550173 6480464 Ethinyl Estradiol results in increased expression of EHMT2 mRNA CTD PMID:17942748 2,3,7,8-tetrachlorodibenzodioxine multiple interactions ISO RGD:1550173 6480464 [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of EHMT2 mRNA CTD PMID:17942748 2,3,7,8-tetrachlorodibenzodioxine affects expression ISO RGD:1550173 6480464 Tetrachlorodibenzodioxin affects the expression of EHMT2 mRNA CTD PMID:21570461 2,6-dinitrotoluene affects expression EXP 6480464 2, 6-dinitrotoluene affects the expression of EHMT2 mRNA CTD PMID:21346803 4,4'-diaminodiphenylmethane decreases expression ISO RGD:1550173 6480464 4, 4'-diaminodiphenylmethane results in decreased expression of EHMT2 mRNA CTD PMID:18648102 4-vinylcyclohexene dioxide affects expression ISO RGD:1550173 6480464 4-vinyl-1-cyclohexene dioxide affects the expression of EHMT2 mRNA CTD PMID:20829426 acetylsalicylic acid increases expression ISO RGD:1605700 6480464 Aspirin results in increased expression of EHMT2 mRNA CTD PMID:11906190 afatinib multiple interactions ISO RGD:1605700 6480464 afatinib inhibits the reaction [EGF protein results in increased expression of EHMT2 protein] CTD PMID:28787001 aflatoxin B1 increases expression ISO RGD:1550173 6480464 Aflatoxin B1 results in increased expression of EHMT2 mRNA CTD PMID:19770486 aflatoxin B1 increases methylation ISO RGD:1605700 6480464 Aflatoxin B1 results in increased methylation of EHMT2 polyA tail CTD PMID:30157460 aflatoxin B1 decreases methylation ISO RGD:1605700 6480464 Aflatoxin B1 results in decreased methylation of EHMT2 gene CTD PMID:27153756 all-trans-retinoic acid multiple interactions ISO RGD:1550173 6480464 EHMT2 protein promotes the reaction [Tretinoin promotes the reaction [CBX1 protein binds to POU5F1 promoter]] more ... CTD PMID:16415856 arsane affects methylation ISO RGD:1605700 6480464 Arsenic affects the methylation of EHMT2 gene CTD PMID:25304211 arsenic atom affects methylation ISO RGD:1605700 6480464 Arsenic affects the methylation of EHMT2 gene CTD PMID:25304211 arsenic(3+) affects methylation ISO RGD:1605700 6480464 Arsenic affects the methylation of EHMT2 gene CTD PMID:25304211 arsenite(3-) increases expression ISO RGD:1605700 6480464 arsenite results in increased expression of EHMT2 mRNA, arsenite results in increased expression of EHMT2 protein CTD PMID:18321869 benzo[a]pyrene affects methylation ISO RGD:1605700 6480464 Benzo(a)pyrene affects the methylation of EHMT2 exon CTD PMID:30157460 bis(2-ethylhexyl) phthalate decreases expression ISO RGD:1550173 6480464 Diethylhexyl Phthalate results in decreased expression of EHMT2 mRNA, Diethylhexyl Phthalate results in decreased expression of EHMT2 protein CTD PMID:25975992 bisphenol A affects expression EXP 6480464 bisphenol A affects the expression of EHMT2 mRNA CTD PMID:25181051 bisphenol A increases expression ISO RGD:1605700 6480464 bisphenol A results in increased expression of EHMT2 mRNA CTD PMID:28765096 , PMID:29275510 bortezomib decreases expression ISO RGD:1605700 6480464 Bortezomib results in decreased expression of EHMT2 mRNA CTD PMID:20977926 C60 fullerene increases expression EXP 6480464 fullerene C60 results in increased expression of EHMT2 mRNA CTD PMID:19167457 cadmium atom decreases expression ISO RGD:1550173 6480464 Cadmium results in decreased expression of EHMT2 mRNA CTD PMID:24067728 carbamazepine affects expression ISO RGD:1605700 6480464 Carbamazepine affects the expression of EHMT2 mRNA CTD PMID:25979313 carbon nanotube decreases expression ISO RGD:1550173 6480464 Nanotubes, Carbon results in decreased expression of EHMT2 mRNA CTD PMID:25554681 cisplatin multiple interactions ISO RGD:1605700 6480464 [Cisplatin co-treated with jinfukang] results in increased expression of EHMT2 mRNA CTD PMID:27392435 clofibrate decreases expression ISO RGD:1550173 6480464 Clofibrate results in decreased expression of EHMT2 mRNA CTD PMID:23811191 cocaine multiple interactions ISO RGD:1550173 6480464 Cocaine inhibits the reaction [Cocaine promotes the reaction [EHMT2 protein binds to FOSB protein]] more ... CTD PMID:20056891 cocaine decreases response to substance ISO RGD:1550173 6480464 EHMT2 results in decreased susceptibility to Cocaine CTD PMID:20056891 cocaine decreases expression ISO RGD:1550173 6480464 Cocaine results in decreased expression of EHMT2 mRNA, Cocaine results in decreased expression of EHMT2 protein CTD PMID:20056891 copper(II) sulfate decreases expression ISO RGD:1605700 6480464 Copper Sulfate results in decreased expression of EHMT2 mRNA CTD PMID:19549813 cyclosporin A decreases expression ISO RGD:1605700 6480464 Cyclosporine results in decreased expression of EHMT2 mRNA CTD PMID:25562108 cylindrospermopsin increases expression ISO RGD:1605700 6480464 cylindrospermopsin results in increased expression of EHMT2 mRNA, cylindrospermopsin results in increased expression of EHMT2 protein CTD PMID:24921660 desferrioxamine B decreases expression ISO RGD:1605700 6480464 Deferoxamine results in decreased expression of EHMT2 mRNA CTD PMID:23483119 dicrotophos increases expression ISO RGD:1605700 6480464 dicrotophos results in increased expression of EHMT2 mRNA CTD PMID:28302478 dorsomorphin multiple interactions ISO RGD:1605700 6480464 [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1 more ... CTD PMID:27188386 doxorubicin multiple interactions ISO RGD:1605700 6480464 Doxorubicin promotes the reaction [EHMT2 protein binds to BIRC5 promoter] CTD PMID:17124180 doxorubicin decreases expression ISO RGD:1605700 6480464 Doxorubicin results in decreased expression of EHMT2 mRNA CTD PMID:29803840 ethanol affects splicing ISO RGD:1550173 6480464 Ethanol affects the splicing of EHMT2 mRNA CTD PMID:30319688 glyphosate increases expression EXP 6480464 glyphosate results in increased expression of EHMT2 mRNA CTD PMID:26302742 hydralazine multiple interactions ISO RGD:1605700 6480464 [Hydralazine co-treated with Valproic Acid] results in increased expression of EHMT2 mRNA CTD PMID:17183730 hydroquinone decreases expression ISO RGD:1605700 6480464 hydroquinone results in decreased expression of EHMT2 protein CTD PMID:27979589 hypochlorous acid decreases expression ISO RGD:1550173 6480464 Hypochlorous Acid results in decreased expression of EHMT2 mRNA CTD PMID:19376150 methamphetamine increases expression ISO RGD:1550173 6480464 Methamphetamine results in increased expression of EHMT2 mRNA CTD PMID:26307267 methoxychlor affects expression ISO RGD:1550173 6480464 Methoxychlor affects the expression of EHMT2 mRNA CTD PMID:20829426 myo-inositol hexakisphosphate multiple interactions ISO RGD:1550173 6480464 Phytic Acid inhibits the reaction [Urethane results in increased expression of EHMT2 mRNA], Phytic Acid inhibits the reaction [Urethane results in increased expression of EHMT2 protein] CTD PMID:25168426 nickel atom multiple interactions ISO RGD:1605700 6480464 Nickel results in decreased expression of and results in decreased activity of EHMT2 protein CTD PMID:16648469 nickel sulfate increases expression ISO RGD:1605700 6480464 nickel sulfate results in increased expression of EHMT2 mRNA CTD PMID:22714537 nitric oxide decreases expression ISO RGD:1605700 6480464 Nitric Oxide results in decreased expression of EHMT2 protein CTD PMID:23546878 ozone decreases expression ISO RGD:1550173 6480464 Ozone results in decreased expression of EHMT2 mRNA CTD PMID:17460151 paracetamol affects expression ISO RGD:1550173 6480464 Acetaminophen affects the expression of EHMT2 mRNA CTD PMID:17562736 paracetamol decreases expression ISO RGD:1605700 6480464 Acetaminophen results in decreased expression of EHMT2 mRNA CTD PMID:29067470 phenylmercury acetate decreases expression ISO RGD:1605700 6480464 Phenylmercuric Acetate results in decreased expression of EHMT2 mRNA CTD PMID:26272509 phenylmercury acetate multiple interactions ISO RGD:1605700 6480464 [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of EHMT2 mRNA CTD PMID:27188386 potassium dichromate multiple interactions ISO RGD:1605700 6480464 EHMT2 protein promotes the reaction [Potassium Dichromate results in increased expression of H2AX protein modified form] CTD PMID:29391238 potassium dichromate increases expression ISO RGD:1605700 6480464 Potassium Dichromate results in increased expression of EHMT2 protein CTD PMID:29391238 SB 431542 multiple interactions ISO RGD:1605700 6480464 [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1 more ... CTD PMID:27188386 sodium arsenite multiple interactions ISO RGD:1605700 6480464 BRD4770 inhibits the reaction [sodium arsenite promotes the reaction [EHMT2 protein binds to PDK4 promoter]] more ... CTD PMID:27217333 sodium arsenite decreases expression EXP 6480464 sodium arsenite results in decreased expression of EHMT2 mRNA CTD PMID:30557709 sodium arsenite decreases expression ISO RGD:1550173 6480464 sodium arsenite results in decreased expression of EHMT2 mRNA CTD PMID:28414027 sodium arsenite increases expression ISO RGD:1605700 6480464 sodium arsenite results in increased expression of EHMT2 protein CTD PMID:27217333 sodium arsenite multiple interactions ISO RGD:1550173 6480464 sodium arsenite promotes the reaction [EHMT2 protein binds to CDKN2A promoter] CTD PMID:22733434 sulindac decreases expression ISO RGD:1605700 6480464 Sulindac results in decreased expression of EHMT2 mRNA CTD PMID:11906190 testosterone decreases expression ISO RGD:1550173 6480464 Testosterone results in decreased expression of EHMT2 mRNA CTD PMID:21669218 urethane multiple interactions ISO RGD:1550173 6480464 Phytic Acid inhibits the reaction [Urethane results in increased expression of EHMT2 mRNA], Phytic Acid inhibits the reaction [Urethane results in increased expression of EHMT2 protein] CTD PMID:25168426 urethane decreases expression ISO RGD:1605700 6480464 Urethane results in decreased expression of EHMT2 mRNA CTD PMID:28818685 urethane increases expression ISO RGD:1550173 6480464 Urethane results in increased expression of EHMT2 mRNA, Urethane results in increased expression of EHMT2 protein CTD PMID:25168426 valproic acid multiple interactions ISO RGD:1605700 6480464 [Hydralazine co-treated with Valproic Acid] results in increased expression of EHMT2 mRNA more ... CTD PMID:17183730 , PMID:27188386 valproic acid decreases expression ISO RGD:1605700 6480464 Valproic Acid results in decreased expression of EHMT2 mRNA CTD PMID:19101580 more ... valproic acid increases methylation ISO RGD:1605700 6480464 Valproic Acid results in increased methylation of EHMT2 gene CTD PMID:29154799 valproic acid affects expression ISO RGD:1550173 6480464 Valproic Acid affects the expression of EHMT2 mRNA CTD PMID:17963808
Biological Process behavioral response to cocaine ISO RGD:1550173 1624291 MGI:MGI:4418499 (MGI:MGI:5577209 , PMID:24584053) RGD MGI:MGI:5577209 , PMID:24584053 behavioral response to cocaine IEA UniProtKB:Q9Z148 , ensembl:ENSMUSP000000139311600115 GO_REF:0000107 Ensembl GO_REF:0000107 cellular response to cocaine ISO RGD:1550173 1624291 (MGI:MGI:5577209, PMID:24584053) RGD MGI:MGI:5577209 , PMID:24584053 cellular response to cocaine IEA UniProtKB:Q9Z148 , ensembl:ENSMUSP000000139311600115 GO_REF:0000107 Ensembl GO_REF:0000107 cellular response to drug IDA 9588218 RGD cellular response to starvation ISO RGD:1605700 1624291 (PMID:23918802) RGD PMID:23918802 DNA methylation ISO RGD:1550173 1624291 (MGI:MGI:3826717, PMID:18818694) RGD MGI:MGI:3826717 , PMID:18818694 DNA methylation on cytosine within a CG sequence ISO RGD:1550173 1624291 (MGI:MGI:3718157, PMID:17212651) RGD MGI:MGI:3718157 , PMID:17212651 DNA methylation on cytosine within a CG sequence IEA UniProtKB:Q9Z148 , ensembl:ENSMUSP000000139311600115 GO_REF:0000107 Ensembl GO_REF:0000107 fertilization ISO RGD:1550173 1624291 MGI:MGI:3718790 (MGI:MGI:3717933 , PMID:17599069) RGD MGI:MGI:3717933 , PMID:17599069 fertilization IEA UniProtKB:Q9Z148 , ensembl:ENSMUSP000000139311600115 GO_REF:0000107 Ensembl GO_REF:0000107 germ cell development ISO RGD:1550173 1624291 MGI:MGI:3718790 (MGI:MGI:3717933 , PMID:17599069) RGD MGI:MGI:3717933 , PMID:17599069 histone H3-K27 methylation ISO RGD:1550173 1624291 (MGI:MGI:3718157, PMID:17212651) RGD MGI:MGI:3718157 , PMID:17212651 histone H3-K27 methylation IEA UniProtKB:Q9Z148 , ensembl:ENSMUSP000000139311600115 GO_REF:0000107 Ensembl GO_REF:0000107 histone H3-K9 methylation ISO RGD:1550173 1624291 MGI:MGI:3718790 (MGI:MGI:3589499 more ... RGD MGI:MGI:3589499 more ... histone H3-K9 methylation IEA UniProtKB:Q9Z148 , ensembl:ENSMUSP000000139311600115 GO_REF:0000107 Ensembl GO_REF:0000107 histone lysine methylation ISO RGD:1605700 1624291 (PMID:19144645) RGD PMID:19144645 histone lysine methylation IEA InterPro:IPR007728 1600115 GO_REF:0000002 InterPro GO_REF:0000002 histone methylation ISO RGD:1605700 1624291 (PMID:22387026) RGD PMID:22387026 histone methylation ISO RGD:1550173 1624291 (MGI:MGI:5424084, PMID:22387026) RGD MGI:MGI:5424084 , PMID:22387026 long-term memory IMP 9589166 RGD negative regulation of autophagosome assembly ISO RGD:1550173 1624291 (MGI:MGI:5543871, PMID:23918802) RGD MGI:MGI:5543871 , PMID:23918802 negative regulation of autophagosome assembly IEA UniProtKB:Q9Z148 , ensembl:ENSMUSP000000139311600115 GO_REF:0000107 Ensembl GO_REF:0000107 negative regulation of transcription by RNA polymerase II ISO RGD:1550173 1624291 MGI:MGI:4418499 (MGI:MGI:3710033 more ... RGD MGI:MGI:3710033 more ... negative regulation of transcription by RNA polymerase II IEA UniProtKB:Q9Z148 , ensembl:ENSMUSP000000139311600115 GO_REF:0000107 Ensembl GO_REF:0000107 negative regulation of transcription by RNA polymerase II ISO RGD:1605700 1624291 (PMID:19144645) RGD PMID:19144645 neuron fate specification ISO RGD:1550173 1624291 MGI:MGI:4418499 (MGI:MGI:5577209 , PMID:24584053) RGD MGI:MGI:5577209 , PMID:24584053 neuron fate specification IEA UniProtKB:Q9Z148 , ensembl:ENSMUSP000000139311600115 GO_REF:0000107 Ensembl GO_REF:0000107 organ growth ISO RGD:1550173 1624291 MGI:MGI:3718790 (MGI:MGI:3717933 , PMID:17599069) RGD MGI:MGI:3717933 , PMID:17599069 organ growth IEA UniProtKB:Q9Z148 , ensembl:ENSMUSP000000139311600115 GO_REF:0000107 Ensembl GO_REF:0000107 peptidyl-lysine dimethylation ISO RGD:1605700 1624291 (PMID:20118233) RGD PMID:20118233 phenotypic switching ISO RGD:1550173 1624291 MGI:MGI:4418499 (MGI:MGI:5577209 , PMID:24584053) RGD MGI:MGI:5577209 , PMID:24584053 phenotypic switching IEA UniProtKB:Q9Z148 , ensembl:ENSMUSP000000139311600115 GO_REF:0000107 Ensembl GO_REF:0000107 regulation of DNA methylation IDA 9588218 RGD regulation of DNA replication ISO RGD:1605700 1624291 (PMID:22387026) RGD PMID:22387026 regulation of DNA replication IEA UniProtKB:Q9Z148 , ensembl:ENSMUSP000000139311600115 GO_REF:0000107 Ensembl GO_REF:0000107 regulation of DNA replication ISO RGD:1550173 1624291 (MGI:MGI:5424084, PMID:22387026) RGD MGI:MGI:5424084 , PMID:22387026 regulation of histone H3-K4 methylation IMP 9589166 RGD regulation of histone H3-K9 methylation IMP 9589166 RGD regulation of transcription by RNA polymerase II ISO RGD:1550173 1624291 MGI:MGI:3718790 (MGI:MGI:3717933 , PMID:17599069) RGD MGI:MGI:3717933 , PMID:17599069 response to ethanol IEP 9491848 RGD response to fungicide IEP 9588300 RGD response to nutrient levels IEP 9589167 RGD spermatid development ISO RGD:1550173 1624291 MGI:MGI:3718790 (MGI:MGI:3717933 , PMID:17599069) RGD MGI:MGI:3717933 , PMID:17599069 spermatid development IEA UniProtKB:Q9Z148 , ensembl:ENSMUSP000000139311600115 GO_REF:0000107 Ensembl GO_REF:0000107 synaptonemal complex assembly ISO RGD:1550173 1624291 MGI:MGI:3718790 (MGI:MGI:3717933 , PMID:17599069) RGD MGI:MGI:3717933 , PMID:17599069 synaptonemal complex assembly IEA UniProtKB:Q9Z148 , ensembl:ENSMUSP000000139311600115 GO_REF:0000107 Ensembl GO_REF:0000107 Cellular Component chromosome IEA UniProtKB-SubCell:SL-0468 1600115 GO_REF:0000040 UniProt GO_REF:0000040 nuclear chromatin ISO RGD:1605700 1624291 (PMID:19144645) RGD PMID:19144645 nuclear speck IEA UniProtKB:A2ABF9 , ensembl:ENSP000003790781600115 GO_REF:0000107 Ensembl GO_REF:0000107 nuclear speck ISO RGD:1605700 1624291 RGD GO_REF:0000052 nucleolus NOT ISO RGD:1550173 1624291 (MGI:MGI:3690291, PMID:16702210) RGD MGI:MGI:3690291 , PMID:16702210 nucleoplasm ISO RGD:1605700 1624291 RGD GO_REF:0000052 nucleus ISO RGD:1605700 1624291 (PMID:19144645) RGD PMID:19144645 nucleus ISO RGD:1550173 1624291 (MGI:MGI:3511615 more ... RGD MGI:MGI:3511615 more ... nucleus ISO RGD:1550173 1624291 (MGI:MGI:3511615 more ... RGD MGI:MGI:3511615 more ... nucleus IDA 9588218 RGD Molecular Function C2H2 zinc finger domain binding ISO RGD:1605700 1624291 UniProtKB:O88286 (PMID:16702210) RGD PMID:16702210 C2H2 zinc finger domain binding IEA UniProtKB:Q9Z148 , ensembl:ENSMUSP000000139311600115 GO_REF:0000107 Ensembl GO_REF:0000107 C2H2 zinc finger domain binding ISO RGD:1550173 1624291 UniProtKB:O88286 (MGI:MGI:3690291 , PMID:16702210) RGD MGI:MGI:3690291 , PMID:16702210 histone methyltransferase activity (H3-K27 specific) ISO RGD:1550173 1624291 (MGI:MGI:3575040, PMID:15774718) RGD MGI:MGI:3575040 , PMID:15774718 histone methyltransferase activity (H3-K27 specific) IEA UniProtKB:Q9Z148 , ensembl:ENSMUSP000000139311600115 GO_REF:0000107 Ensembl GO_REF:0000107 histone methyltransferase activity (H3-K9 specific) ISO RGD:1550173 1624291 (MGI:MGI:3575040 more ... RGD MGI:MGI:3575040 more ... histone methyltransferase activity (H3-K9 specific) IEA UniProtKB:Q9Z148 , ensembl:ENSMUSP000000139311600115 GO_REF:0000107 Ensembl GO_REF:0000107 histone-lysine N-methyltransferase activity ISO RGD:1550173 1624291 (MGI:MGI:3845989 more ... RGD MGI:MGI:3845989 more ... histone-lysine N-methyltransferase activity IEA InterPro:IPR007728 , InterPro:IPR038034 1600115 GO_REF:0000002 InterPro GO_REF:0000002 histone-lysine N-methyltransferase activity ISO RGD:1605700 1624291 (PMID:19144645), (PMID:22387026) RGD PMID:19144645 , PMID:22387026 p53 binding ISO RGD:1605700 1624291 UniProtKB:P04637 (PMID:20118233) RGD PMID:20118233 p53 binding IEA InterPro:IPR038034 1600115 GO_REF:0000002 InterPro GO_REF:0000002 promoter-specific chromatin binding ISO RGD:1550173 1624291 (MGI:MGI:5700289, PMID:22770845) RGD MGI:MGI:5700289 , PMID:22770845 promoter-specific chromatin binding IEA UniProtKB:Q9Z148 , ensembl:ENSMUSP000000139311600115 GO_REF:0000107 Ensembl GO_REF:0000107 promoter-specific chromatin binding ISO RGD:1605700 1624291 (PMID:23918802) RGD PMID:23918802 protein binding IPI RGD:620979 9588218 RGD protein binding ISO RGD:1605700 1624291 UniProtKB:A0A0S2Z5X4 more ... RGD PMID:16189514 more ... protein binding ISO RGD:1550173 1624291 UniProtKB:O70237 more ... RGD MGI:MGI:3575040 more ... protein binding ISO RGD:1550173 1624291 UniProtKB:O70237 more ... RGD MGI:MGI:3575040 more ... protein-lysine N-methyltransferase activity ISO RGD:1605700 1624291 (PMID:20118233) RGD PMID:20118233 RNA polymerase II regulatory region sequence-specific DNA binding ISO RGD:1550173 1624291 (MGI:MGI:5050612, PMID:21402781) RGD MGI:MGI:5050612 , PMID:21402781 RNA polymerase II regulatory region sequence-specific DNA binding IEA UniProtKB:Q9Z148 , ensembl:ENSMUSP000000139311600115 GO_REF:0000107 Ensembl GO_REF:0000107 zinc ion binding IEA InterPro:IPR007728 1600115 GO_REF:0000002 InterPro GO_REF:0000002
Gene-Chemical Interaction Annotations
