Rgl2 (ral guanine nucleotide dissociation stimulator-like 2) - Rat Genome Database

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Gene: Rgl2 (ral guanine nucleotide dissociation stimulator-like 2) Rattus norvegicus
Analyze
Symbol: Rgl2
Name: ral guanine nucleotide dissociation stimulator-like 2
RGD ID: 1302985
Description: Predicted to enable guanyl-nucleotide exchange factor activity. Predicted to be involved in Ras protein signal transduction and positive regulation of GTPase activity. Predicted to act upstream of or within negative regulation of cardiac muscle cell apoptotic process; positive regulation of phosphatidylinositol 3-kinase signaling; and regulation of Ral protein signal transduction. Predicted to be active in plasma membrane. Orthologous to human RGL2 (ral guanine nucleotide dissociation stimulator like 2); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene; 2,6-dinitrotoluene.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Ke1.5; MGC124925; RAB2, member RAS oncogene family-like; Rab2l
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2204,948,495 - 4,956,774 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl204,948,497 - 4,969,911 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx205,671,867 - 5,679,650 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0205,033,612 - 5,041,395 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0205,514,408 - 5,522,140 (-)NCBIRnor_WKY
Rnor_6.0205,458,509 - 5,466,853 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl205,458,509 - 5,466,265 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0207,517,121 - 7,524,877 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4205,100,260 - 5,108,016 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1205,100,488 - 5,109,200 (-)NCBI
Celera206,532,606 - 6,540,362 (-)NCBICelera
Cytogenetic Map20p12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. The genomic sequence and comparative analysis of the rat major histocompatibility complex. Hurt P, etal., Genome Res 2004 Apr;14(4):631-9.
4. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
5. GOA pipeline RGD automated data pipeline
6. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
7. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12477932   PMID:24069211  


Genomics

Comparative Map Data
Rgl2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2204,948,495 - 4,956,774 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl204,948,497 - 4,969,911 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx205,671,867 - 5,679,650 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0205,033,612 - 5,041,395 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0205,514,408 - 5,522,140 (-)NCBIRnor_WKY
Rnor_6.0205,458,509 - 5,466,853 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl205,458,509 - 5,466,265 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0207,517,121 - 7,524,877 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4205,100,260 - 5,108,016 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1205,100,488 - 5,109,200 (-)NCBI
Celera206,532,606 - 6,540,362 (-)NCBICelera
Cytogenetic Map20p12NCBI
RGL2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38633,291,654 - 33,301,612 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl633,291,654 - 33,298,942 (-)EnsemblGRCh38hg38GRCh38
GRCh37633,259,431 - 33,266,719 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36633,367,414 - 33,374,716 (-)NCBINCBI36Build 36hg18NCBI36
Build 34633,367,415 - 33,374,716NCBI
Celera634,813,789 - 34,821,534 (-)NCBICelera
Cytogenetic Map6p21.32NCBI
HuRef633,001,065 - 33,008,799 (-)NCBIHuRef
CHM1_1633,261,371 - 33,269,102 (-)NCBICHM1_1
T2T-CHM13v2.0633,113,016 - 33,120,304 (-)NCBIT2T-CHM13v2.0
Rgl2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391734,148,813 - 34,156,661 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1734,148,517 - 34,156,661 (+)EnsemblGRCm39 Ensembl
GRCm381733,929,514 - 33,937,687 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1733,929,543 - 33,937,687 (+)EnsemblGRCm38mm10GRCm38
MGSCv371734,066,839 - 34,074,632 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361733,540,348 - 33,548,141 (+)NCBIMGSCv36mm8
Celera1736,682,808 - 36,690,599 (+)NCBICelera
Cytogenetic Map17B1NCBI
Rgl2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554371,851,005 - 1,856,720 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554371,851,005 - 1,857,567 (-)NCBIChiLan1.0ChiLan1.0
RGL2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1633,978,024 - 33,985,749 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl633,978,024 - 33,985,749 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0632,863,954 - 32,871,684 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
RGL2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1122,731,366 - 2,739,141 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl122,731,983 - 2,739,032 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha122,812,550 - 2,820,074 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0123,063,045 - 3,070,569 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl123,063,050 - 3,070,550 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1122,730,271 - 2,737,794 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0122,811,759 - 2,819,279 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0122,886,472 - 2,893,996 (-)NCBIUU_Cfam_GSD_1.0
Rgl2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494638,384,992 - 38,392,961 (-)NCBIHiC_Itri_2
SpeTri2.0NW_00493647625,566,714 - 25,574,667 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
RGL2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl729,655,743 - 29,662,375 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1729,655,530 - 29,662,375 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2734,159,294 - 34,167,044 (-)NCBISscrofa10.2Sscrofa10.2susScr3
RGL2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11738,777,719 - 38,785,829 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1738,778,859 - 38,785,984 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604433,126,279 - 33,133,987 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Rgl2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475423,522,258 - 23,529,766 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462475423,522,277 - 23,530,541 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Position Markers
RH129413  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2204,956,949 - 4,957,154 (+)MAPPERmRatBN7.2
Rnor_6.0205,466,964 - 5,467,168NCBIRnor6.0
Rnor_5.0207,525,576 - 7,525,780UniSTSRnor5.0
RGSC_v3.4205,108,715 - 5,108,919UniSTSRGSC3.4
Celera206,541,061 - 6,541,265UniSTS
RH 3.4 Map2054.33UniSTS
Cytogenetic Map20p12UniSTS
RH138742  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2204,957,520 - 4,957,657 (+)MAPPERmRatBN7.2
Rnor_6.0205,467,536 - 5,467,672NCBIRnor6.0
Rnor_5.0207,526,148 - 7,526,284UniSTSRnor5.0
RGSC_v3.4205,109,287 - 5,109,423UniSTSRGSC3.4
Celera206,541,633 - 6,541,769UniSTS
RH 3.4 Map2055.13UniSTS
Cytogenetic Map20p12UniSTS
RH140614  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2204,948,525 - 4,948,716 (+)MAPPERmRatBN7.2
Rnor_6.0205,458,540 - 5,458,730NCBIRnor6.0
Rnor_5.0207,517,152 - 7,517,342UniSTSRnor5.0
RGSC_v3.4205,100,291 - 5,100,481UniSTSRGSC3.4
Celera206,532,637 - 6,532,827UniSTS
RH 3.4 Map2058.7UniSTS
Cytogenetic Map20p12UniSTS


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1354642Despr15Despair related QTL 150.0027locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)20124159021Rat
1600382Edcs3Endometrial carcinoma susceptibility QTL33.50.003uterus morphology trait (VT:0001120)percentage of study population developing endometrioid carcinoma during a period of time (CMO:0001759)20125159026Rat
2317851Alcrsp22Alcohol response QTL 223.20.05response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)20127339237Rat
1641893Alcrsp7Alcohol response QTL 7response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)20127339237Rat
8694189Bw153Body weight QTL 1533.130.001body mass (VT:0001259)body weight gain (CMO:0000420)20129191651Rat
9590275Scort15Serum corticosterone level QTL 153.480.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)20129191651Rat
7411650Foco23Food consumption QTL 2320.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)20129191651Rat
9590109Sffal8Serum free fatty acids level QTL 85.320.01blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)20129191651Rat
9589155Insul32Insulin level QTL 326.380.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)20129191651Rat
6893685Bw111Body weight QTL 1112.70.004body mass (VT:0001259)body weight (CMO:0000012)20132578807Rat
7411668Foco32Food consumption QTL 3280.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)20136600972Rat
9590252Scort12Serum corticosterone level QTL 1220.460.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)20136600972Rat
2305926Iddm37Insulin dependent diabetes mellitus QTL 376blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)20152784246527842Rat
2306850Pia40Pristane induced arthritis QTL 400.0001joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)2015279595304575Rat
1641915Colcr9Colorectal carcinoma resistance QTL 92.970.0024intestine integrity trait (VT:0010554)benign colorectal tumor number (CMO:0001795)20153065546530655Rat
1598816Memor12Memory QTL 122.4exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)20260683647606836Rat
2317057Aia27Adjuvant induced arthritis QTL 272.83joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)20289259726381954Rat
1300152Bp195Blood pressure QTL 1953.46arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2036216499243559Rat
1331772Cdexp2CD45RC expression in CD8 T cells QTL 25.7CD8-positive T cell quantity (VT:0008077)blood CD45RC(high) CD8 T cell count to CD45RC(low) CD8 T cell count ratio (CMO:0001990)20362164910078919Rat
61432Cia1Collagen induced arthritis QTL 1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)20362165614101050Rat
61474Eae1Experimental allergic encephalomyelitis QTL 13nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis severity score (CMO:0001419)2046066076691706Rat
4889857Pur27Proteinuria QTL 2712.20.001total urine protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)20460660717617956Rat
1558640Prcs2Prostate cancer susceptibility QTL 23.3prostate integrity trait (VT:0010571)percentage of study population developing ventral prostate tumorous lesions during a period of time (CMO:0000943)20460660717617956Rat
7175096Tcs1T cell selection QTL 1T cell selectionexpression2047270785024580Rat

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:269
Count of miRNA genes:177
Interacting mature miRNAs:205
Transcripts:ENSRNOT00000000554
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 35 21 6 19 6 1 4 66 26 34 11 1
Low 8 36 35 35 7 7 8 9 7 7
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000000554   ⟹   ENSRNOP00000000554
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl204,948,497 - 4,956,252 (-)Ensembl
Rnor_6.0 Ensembl205,458,509 - 5,466,265 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000092234
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl205,462,394 - 5,463,341 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000092372   ⟹   ENSRNOP00000075911
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl204,948,497 - 4,956,252 (-)Ensembl
Rnor_6.0 Ensembl205,458,509 - 5,466,256 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000092380
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl205,460,070 - 5,460,993 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000092702
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl205,464,142 - 5,465,089 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000092727
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl205,458,971 - 5,459,721 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000112353   ⟹   ENSRNOP00000090030
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl204,948,497 - 4,969,911 (-)Ensembl
RefSeq Acc Id: NM_212547   ⟹   NP_997712
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2204,948,495 - 4,956,251 (-)NCBI
Rnor_6.0205,458,509 - 5,466,265 (-)NCBI
Rnor_5.0207,517,121 - 7,524,877 (-)NCBI
RGSC_v3.4205,100,260 - 5,108,016 (-)RGD
Celera206,532,606 - 6,540,362 (-)RGD
Sequence:
RefSeq Acc Id: XM_039098506   ⟹   XP_038954434
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2204,948,495 - 4,956,774 (-)NCBI
RefSeq Acc Id: XM_039098507   ⟹   XP_038954435
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2204,948,495 - 4,955,767 (-)NCBI
RefSeq Acc Id: XR_005497185
RefSeq Status:
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2204,950,016 - 4,956,774 (-)NCBI
RefSeq Acc Id: XR_005497186
RefSeq Status:
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2204,948,495 - 4,956,774 (-)NCBI
RefSeq Acc Id: XR_005497187
RefSeq Status:
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2204,950,808 - 4,956,774 (-)NCBI
Protein Sequences
Protein RefSeqs NP_997712 (Get FASTA)   NCBI Sequence Viewer  
  XP_038954434 (Get FASTA)   NCBI Sequence Viewer  
  XP_038954435 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAI07440 (Get FASTA)   NCBI Sequence Viewer  
  CAE83921 (Get FASTA)   NCBI Sequence Viewer  
  EDL96849 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_997712   ⟸   NM_212547
- UniProtKB: Q6MGC5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000075911   ⟸   ENSRNOT00000092372
RefSeq Acc Id: ENSRNOP00000000554   ⟸   ENSRNOT00000000554
RefSeq Acc Id: XP_038954434   ⟸   XM_039098506
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038954435   ⟸   XM_039098507
- Peptide Label: isoform X2
RefSeq Acc Id: ENSRNOP00000090030   ⟸   ENSRNOT00000112353
Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q6MGC5-F1-model_v2 AlphaFold Q6MGC5 1-778 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Strain Variation

Strain Sequence Variants (mRatBN7.2)
ACI/EurMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
ACI/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN-Lx/CubMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/NHsdMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/NHsdMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/SsN (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BUF/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BXH2/CubMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BXH3/CubMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
DA/OlaHsd (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Envigo
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/DuCrl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/N (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/NCrl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FHH/EurMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FXLE16/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FXLE18/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
GK/FarMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB10/IpcvMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB2/IpcvMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB20/IpcvMcwi (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB31/IpcvMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB4/IpcvMcwi (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LE/Stm (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEW/Crl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF10A/StmMcwi (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF11/Stm (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF1A/Stm (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF1C/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF2B/Stm (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF3/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF4/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LH/MavRrrcAek (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LL/MavRrrcAek (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LN/MavRrrcAek (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
M520/N (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
M520/NRrrcMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
MR/N (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
MWF/Hsd (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
PVG/Seac (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SHR/OlalpcvMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SHRSP/A3NCrl (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SR/JrHsd (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Envigo
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SS/JrHsdMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WAG/RijCrl (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WKY/N (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WKY/NCrl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WN/N (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
Damaging Variants


Assembly: Rnor_6.0

Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Strain
20 5462199 5462200 T A snv F344/N (2020)


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1302985 AgrOrtholog
BioCyc Gene G2FUF-4516 BioCyc
Ensembl Genes ENSRNOG00000000474 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000000554 ENTREZGENE
  ENSRNOP00000000554.4 UniProtKB/TrEMBL
  ENSRNOP00000075911.2 UniProtKB/TrEMBL
  ENSRNOP00000090030.1 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000000554 ENTREZGENE
  ENSRNOT00000000554.7 UniProtKB/TrEMBL
  ENSRNOT00000092372.2 UniProtKB/TrEMBL
  ENSRNOT00000112353.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.840.10 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7121126 IMAGE-MGC_LOAD
InterPro Ras-assoc UniProtKB/TrEMBL
  Ras-like_GEF UniProtKB/TrEMBL
  Ras-like_Gua-exchang_fac_N UniProtKB/TrEMBL
  Ras_G-nucl-exch_fac_CS UniProtKB/TrEMBL
  Ras_GEF_dom UniProtKB/TrEMBL
  RASGEF_cat_dom_sf UniProtKB/TrEMBL
  RasGRF_CDC25 UniProtKB/TrEMBL
  RGL2 UniProtKB/TrEMBL
  Ubiquitin-rel_dom UniProtKB/TrEMBL
KEGG Report rno:294283 UniProtKB/TrEMBL
MGC_CLONE MGC:124925 IMAGE-MGC_LOAD
NCBI Gene 294283 ENTREZGENE
PANTHER PTHR23113 UniProtKB/TrEMBL
  PTHR23113:SF213 UniProtKB/TrEMBL
Pfam PF00788 UniProtKB/TrEMBL
  RasGEF UniProtKB/TrEMBL
  RasGEF_N UniProtKB/TrEMBL
PhenoGen Rgl2 PhenoGen
PROSITE PS50200 UniProtKB/TrEMBL
  RASGEF UniProtKB/TrEMBL
  RASGEF_CAT UniProtKB/TrEMBL
  RASGEF_NTER UniProtKB/TrEMBL
SMART RasGEF UniProtKB/TrEMBL
  RasGEFN UniProtKB/TrEMBL
  SM00314 UniProtKB/TrEMBL
Superfamily-SCOP Ras_GEF UniProtKB/TrEMBL
  SSF54236 UniProtKB/TrEMBL
UniProt A0A0U1RS29_RAT UniProtKB/TrEMBL
  A0A8I6A8H6_RAT UniProtKB/TrEMBL
  Q6MGC5 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-03-04 Rgl2  ral guanine nucleotide dissociation stimulator-like 2  Rab2l  RAB2, member RAS oncogene family-like  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-02-14 Rab2l  RAB2, member RAS oncogene family-like      Symbol and Name status set to provisional 70820 PROVISIONAL