RT1-A2 (RT1 class Ia, locus A2) - Rat Genome Database

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Gene: RT1-A2 (RT1 class Ia, locus A2) Rattus norvegicus
Analyze
Symbol: RT1-A2
Name: RT1 class Ia, locus A2
RGD ID: 1595923
Description: Predicted to enable beta-2-microglobulin binding activity; peptide antigen binding activity; and signaling receptor binding activity. Predicted to be involved in several processes, including positive regulation of gene expression; regulation of leukocyte mediated cytotoxicity; and regulation of lymphocyte activation. Predicted to act upstream of or within antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway, TAP-dependent and inner ear development. Predicted to be located in cell surface and plasma membrane. Predicted to be part of MHC class I protein complex and MHC class Ib protein complex. Predicted to be active in external side of plasma membrane and extracellular space. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); asthma (multiple); autoimmune disease (multiple); eye disease (multiple); and inner ear disease (multiple). Orthologous to several human genes including HLA-B (major histocompatibility complex, class I, B); HLA-C (major histocompatibility complex, class I, C); and HLA-E (major histocompatibility complex, class I, E); PARTICIPATES IN allograft rejection pathway; antigen processing and presentation pathway; autoimmune thyroiditis pathway; INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine; 2,6-dinitrotoluene.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: MGC95123; RT1 class I gene (A-2); RT1 class Ia, A2n; RT1 class Ia, locus A2 (mapped); RT1-A2_mapped; RT1-A2n; RT1.A2(N); RT1A-2
RGD Orthologs
Human
Mouse
Bonobo
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8204,872,720 - 4,876,425 (+)NCBIGRCr8
mRatBN7.2204,870,939 - 4,910,183 (+)NCBImRatBN7.2mRatBN7.2
Rnor_6.0205,374,990 - 5,378,536 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl205,374,985 - 5,378,539 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0207,433,437 - 7,436,984 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4205,021,816 - 5,025,341 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera206,470,599 - 6,474,124 (+)NCBICelera
Cytogenetic Map20p12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (ISO)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrobenzenesulfonic acid  (ISO)
2,6-dinitrotoluene  (EXP)
3,3',5,5'-tetrabromobisphenol A  (EXP)
3,4-methylenedioxymethamphetamine  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4-hydroxynon-2-enal  (ISO)
4-phenylbutyric acid  (ISO)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
aconitine  (EXP)
all-trans-retinoic acid  (ISO)
ammonium acetate  (EXP)
ammonium chloride  (EXP)
antimycin A  (ISO)
antirheumatic drug  (ISO)
aristolochic acid A  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
C60 fullerene  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
calcitriol  (ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
cefuroxime  (ISO)
chlordecone  (ISO)
chlorpyrifos  (ISO)
ciprofloxacin  (ISO)
clindamycin  (ISO)
clozapine  (ISO)
cobalt dichloride  (ISO)
crocidolite asbestos  (ISO)
Cuprizon  (EXP)
cyclosporin A  (ISO)
diarsenic trioxide  (ISO)
dibutyl phthalate  (EXP)
dioxygen  (ISO)
disodium selenite  (ISO)
diuron  (EXP)
doxorubicin  (ISO)
elemental selenium  (ISO)
entinostat  (ISO)
etoposide  (ISO)
famotidine  (ISO)
ferric oxide  (ISO)
ferroheme b  (ISO)
fumonisin B1  (ISO)
gentamycin  (EXP)
heme b  (ISO)
hydrochlorothiazide  (ISO)
inulin  (ISO)
isotretinoin  (ISO)
ketorolac  (ISO)
lincomycin  (ISO)
malathion  (ISO)
menadione  (ISO)
methidathion  (ISO)
methylmercury chloride  (ISO)
methylparaben  (ISO)
mifepristone  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
N-methyl-N-nitrosourea  (EXP)
ochratoxin A  (ISO)
ofloxacin  (ISO)
ozone  (ISO)
paracetamol  (EXP,ISO)
pentachlorophenol  (ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
pirinixic acid  (EXP,ISO)
piroxicam  (ISO)
progesterone  (ISO)
quercitrin  (ISO)
resveratrol  (ISO)
selenium atom  (ISO)
simvastatin  (ISO)
succimer  (ISO)
sunitinib  (ISO)
tamibarotene  (ISO)
temozolomide  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone  (ISO)
tetrachloromethane  (EXP)
thalidomide  (ISO)
thimerosal  (ISO)
titanium dioxide  (ISO)
tolmetin  (ISO)
trichloroethene  (ISO)
Triptolide  (EXP)
troglitazone  (ISO)
uranium atom  (ISO)
urethane  (ISO)
valproic acid  (ISO)
vitamin E  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
adaptive immune response  (ISO)
antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent  (IBA)
antigen processing and presentation of endogenous peptide antigen via MHC class Ib  (IBA,ISO)
antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway, TAP-dependent  (ISO)
antigen processing and presentation of exogenous peptide antigen via MHC class Ib  (ISO)
CD8-positive, alpha-beta T cell activation  (ISO)
immune response  (IBA)
inner ear development  (ISO)
natural killer cell tolerance induction  (ISO)
negative regulation of natural killer cell activation  (ISO)
negative regulation of natural killer cell mediated cytotoxicity  (ISO)
negative regulation of T cell proliferation  (ISO)
positive regulation of antibody-dependent cellular cytotoxicity  (ISO)
positive regulation of CD8-positive, alpha-beta T cell activation  (ISO)
positive regulation of CD8-positive, alpha-beta T cell proliferation  (ISO)
positive regulation of immunoglobulin production  (ISO)
positive regulation of interleukin-13 production  (ISO)
positive regulation of interleukin-4 production  (ISO)
positive regulation of natural killer cell activation  (ISO)
positive regulation of natural killer cell cytokine production  (ISO)
positive regulation of natural killer cell mediated cytotoxicity  (ISO)
positive regulation of natural killer cell mediated immunity  (ISO)
positive regulation of natural killer cell proliferation  (ISO)
positive regulation of T cell mediated cytotoxicity  (IBA,ISO)
positive regulation of TRAIL production  (ISO)
positive regulation of tumor necrosis factor production  (ISO)
protection from natural killer cell mediated cytotoxicity  (ISO)
regulation of natural killer cell mediated immunity  (ISO)
T cell mediated cytotoxicity  (ISO)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. A novel instance of class I modification (cim) affecting two of three rat class I RT1-A molecules within one MHC haplotype. Gonzalez-Munoz AL, etal., J Immunol. 2003 Jul 1;171(1):274-84.
3. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
4. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
5. GOA pipeline RGD automated data pipeline
6. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:1538753   PMID:9427624   PMID:9443915   PMID:9486650   PMID:9754572   PMID:10799855   PMID:11685465   PMID:12411439   PMID:12477932   PMID:12763482   PMID:12902470   PMID:14735325  
PMID:16474394   PMID:17179229   PMID:18083576   PMID:18339401   PMID:18448674   PMID:19666135   PMID:20018625   PMID:22562814   PMID:23100519   PMID:23335510   PMID:25631937   PMID:28676677  
PMID:29531166   PMID:30087334   PMID:30134159  


Genomics

Comparative Map Data
RT1-A2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8204,872,720 - 4,876,425 (+)NCBIGRCr8
mRatBN7.2204,870,939 - 4,910,183 (+)NCBImRatBN7.2mRatBN7.2
Rnor_6.0205,374,990 - 5,378,536 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl205,374,985 - 5,378,539 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0207,433,437 - 7,436,984 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4205,021,816 - 5,025,341 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera206,470,599 - 6,474,124 (+)NCBICelera
Cytogenetic Map20p12NCBI
HLA-E
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38630,489,509 - 30,494,194 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl630,489,509 - 30,494,194 (+)EnsemblGRCh38hg38GRCh38
GRCh37630,457,286 - 30,461,971 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36630,565,250 - 30,569,077 (+)NCBINCBI36Build 36hg18NCBI36
Build 34630,565,287 - 30,568,337NCBI
Celera632,055,310 - 32,060,109 (+)NCBICelera
Cytogenetic Map6p22.1NCBI
HuRef630,257,312 - 30,262,111 (+)NCBIHuRef
CHM1_1630,459,288 - 30,464,087 (+)NCBICHM1_1
T2T-CHM13v2.0630,353,696 - 30,358,381 (+)NCBIT2T-CHM13v2.0
H2-T23
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391736,340,869 - 36,343,593 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1736,340,665 - 36,343,747 (-)EnsemblGRCm39 Ensembl
GRCm381736,029,977 - 36,032,701 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1736,029,773 - 36,032,855 (-)EnsemblGRCm38mm10GRCm38
MGSCv371736,166,922 - 36,169,646 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361735,638,030 - 35,640,754 (-)NCBIMGSCv36mm8
Celera1739,547,532 - 39,600,702 (-)NCBICelera
Cytogenetic Map17B1NCBI
cM Map1718.86NCBI
LOC100977055
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2545,048,829 - 45,053,645 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1641,011,935 - 41,016,698 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0630,233,293 - 30,238,056 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1631,104,186 - 31,108,978 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl631,101,251 - 31,107,262 (+)Ensemblpanpan1.1panPan2

Variants

.
Variants in RT1-A2
4891 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:168
Count of miRNA genes:75
Interacting mature miRNAs:79
Transcripts:ENSRNOT00000038660, ENSRNOT00000052270
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1354642Despr15Despair related QTL 150.0027locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)20124159021Rat
1600382Edcs3Endometrial carcinoma susceptibility QTL33.50.003uterus morphology trait (VT:0001120)percentage of study population developing endometrioid carcinoma during a period of time (CMO:0001759)20125159026Rat
2317851Alcrsp22Alcohol response QTL 223.20.05response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)20127339237Rat
1641893Alcrsp7Alcohol response QTL 7response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)20127339237Rat
8694189Bw153Body weight QTL 1533.130.001body mass (VT:0001259)body weight gain (CMO:0000420)20129191651Rat
9590275Scort15Serum corticosterone level QTL 153.480.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)20129191651Rat
7411650Foco23Food consumption QTL 2320.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)20129191651Rat
9590109Sffal8Serum free fatty acids level QTL 85.320.01blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)20129191651Rat
9589155Insul32Insulin level QTL 326.380.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)20129191651Rat
6893685Bw111Body weight QTL 1112.70.004body mass (VT:0001259)body weight (CMO:0000012)20132578807Rat
7411668Foco32Food consumption QTL 3280.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)20136600972Rat
9590252Scort12Serum corticosterone level QTL 1220.460.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)20136600972Rat
2305926Iddm37Insulin dependent diabetes mellitus QTL 376blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)20152784246527842Rat
2306850Pia40Pristane induced arthritis QTL 400.0001joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)2015279595304575Rat
1641915Colcr9Colorectal carcinoma resistance QTL 92.970.0024intestine integrity trait (VT:0010554)benign colorectal tumor number (CMO:0001795)20153065546530655Rat
1598816Memor12Memory QTL 122.4exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)20260683647606836Rat
2317057Aia27Adjuvant induced arthritis QTL 272.83joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)20289259726381954Rat
1300152Bp195Blood pressure QTL 1953.46arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2036216499243559Rat
1331772Cdexp2CD45RC expression in CD8 T cells QTL 25.7CD8-positive T cell quantity (VT:0008077)blood CD45RC(high) CD8 T cell count to CD45RC(low) CD8 T cell count ratio (CMO:0001990)20362164910078919Rat
61432Cia1Collagen induced arthritis QTL 1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)20362165614101050Rat
61474Eae1Experimental allergic encephalomyelitis QTL 13nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis severity score (CMO:0001419)2046066076691706Rat
4889857Pur27Proteinuria QTL 2712.20.001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)20460660717617956Rat
1558640Prcs2Prostate cancer susceptibility QTL 23.3prostate integrity trait (VT:0010571)percentage of study population developing ventral prostate tumorous lesions during a period of time (CMO:0000943)20460660717617956Rat
7175096Tcs1T cell selection QTL 1T cell selectionexpression2047270785024580Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 7 26 17 15 17 1 3 9 17 9
Low 30 31 24 4 24 8 10 66 26 23 2 8
Below cutoff 6 5 1

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001008829 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017601545 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063278965 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063278966 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063278967 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063278968 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063278969 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide BC088465 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BX883042 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ218530 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ228760 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ230749 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ231678 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ231785 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ233418 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000020 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  MG963096 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X90376 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

RefSeq Acc Id: ENSRNOT00000038660
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl205,375,650 - 5,377,440 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000052270   ⟹   ENSRNOP00000050701
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl205,374,985 - 5,378,539 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000082497   ⟹   ENSRNOP00000073153
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl203,555,782 - 3,559,486 (-)Ensembl
RefSeq Acc Id: NM_001008829   ⟹   NP_001008829
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8204,872,871 - 4,876,422 (+)NCBI
mRatBN7.2204,870,986 - 4,874,537 (+)NCBI
Rnor_6.0205,375,011 - 5,378,536 (+)NCBI
Rnor_5.0207,433,437 - 7,436,984 (+)NCBI
RGSC_v3.4205,021,816 - 5,025,341 (+)RGD
Celera206,470,599 - 6,474,124 (+)RGD
Sequence:
RefSeq Acc Id: XM_017601545   ⟹   XP_017457034
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8204,872,829 - 4,876,425 (+)NCBI
mRatBN7.2204,870,945 - 4,874,540 (+)NCBI
Rnor_6.0205,374,990 - 5,378,535 (+)NCBI
Sequence:
RefSeq Acc Id: XM_063278965   ⟹   XP_063135035
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8204,872,840 - 4,876,425 (+)NCBI
RefSeq Acc Id: XM_063278966   ⟹   XP_063135036
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8204,872,830 - 4,876,425 (+)NCBI
RefSeq Acc Id: XM_063278967   ⟹   XP_063135037
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8204,872,720 - 4,876,425 (+)NCBI
RefSeq Acc Id: XM_063278968   ⟹   XP_063135038
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8204,872,832 - 4,876,425 (+)NCBI
RefSeq Acc Id: XM_063278969   ⟹   XP_063135039
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8204,872,832 - 4,876,425 (+)NCBI
RefSeq Acc Id: NP_001008829   ⟸   NM_001008829
- Peptide Label: precursor
- UniProtKB: Q6MGB8 (UniProtKB/TrEMBL),   F7ERG5 (UniProtKB/TrEMBL),   P79602 (UniProtKB/TrEMBL),   Q95569 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017457034   ⟸   XM_017601545
- Peptide Label: isoform X6
- UniProtKB: P79602 (UniProtKB/TrEMBL),   Q95569 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000050701   ⟸   ENSRNOT00000052270
RefSeq Acc Id: ENSRNOP00000073153   ⟸   ENSRNOT00000082497
RefSeq Acc Id: XP_063135037   ⟸   XM_063278967
- Peptide Label: isoform X3
RefSeq Acc Id: XP_063135036   ⟸   XM_063278966
- Peptide Label: isoform X2
RefSeq Acc Id: XP_063135039   ⟸   XM_063278969
- Peptide Label: isoform X5
RefSeq Acc Id: XP_063135038   ⟸   XM_063278968
- Peptide Label: isoform X4
RefSeq Acc Id: XP_063135035   ⟸   XM_063278965
- Peptide Label: isoform X1
Protein Domains
Ig-like

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q6MGB8-F1-model_v2 AlphaFold Q6MGB8 1-366 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13701406
Promoter ID:EPDNEW_R11930
Type:single initiation site
Name:RT1-A2_1
Description:RT1 class Ia, locus A2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0205,374,985 - 5,375,045EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1595923 AgrOrtholog
BioCyc Gene G2FUF-4526 BioCyc
Ensembl Genes ENSRNOG00000030712 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000082497.2 UniProtKB/TrEMBL
Gene3D-CATH 2.60.40.10 UniProtKB/TrEMBL
  3.30.500.10 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7127909 IMAGE-MGC_LOAD
InterPro Ig-like UniProtKB/TrEMBL
  Ig-like_dom_sf UniProtKB/TrEMBL
  Ig-like_fold UniProtKB/TrEMBL
  Ig/MHC_CS UniProtKB/TrEMBL
  Ig_C1-set UniProtKB/TrEMBL
  MHC_I-like_Ag-recog UniProtKB/TrEMBL
  MHC_I-like_Ag-recog_sf UniProtKB/TrEMBL
  MHC_I/II-like_Ag-recog UniProtKB/TrEMBL
  MHC_I_a_a1/a2 UniProtKB/TrEMBL
  MHC_I_a_C UniProtKB/TrEMBL
KEGG Report rno:24974 UniProtKB/TrEMBL
MGC_CLONE MGC:95123 IMAGE-MGC_LOAD
NCBI Gene 24974 ENTREZGENE
PANTHER CLASS IB MHC ANTIGEN QA-2-RELATED UniProtKB/TrEMBL
  MHC CLASS I-RELATED UniProtKB/TrEMBL
Pfam C1-set UniProtKB/TrEMBL
  MHC_I UniProtKB/TrEMBL
  MHC_I_C UniProtKB/TrEMBL
PhenoGen RT1-A2 PhenoGen
PRINTS MHCCLASSI UniProtKB/TrEMBL
PROSITE IG_LIKE UniProtKB/TrEMBL
  IG_MHC UniProtKB/TrEMBL
RatGTEx ENSRNOG00000030712 RatGTEx
SMART IGc1 UniProtKB/TrEMBL
Superfamily-SCOP MHC_I/II-like_Ag-recog UniProtKB/TrEMBL
  SSF48726 UniProtKB/TrEMBL
UniProt A0A0G2K4S5_RAT UniProtKB/TrEMBL
  A6JJH0_RAT UniProtKB/TrEMBL
  F7ERG5 ENTREZGENE
  P79602 ENTREZGENE, UniProtKB/TrEMBL
  Q6MGB8 ENTREZGENE, UniProtKB/TrEMBL
  Q95569 ENTREZGENE
UniProt Secondary F7ERG5 UniProtKB/TrEMBL
  Q95569 UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2007-04-12 RT1-A2  RT1 class Ia, locus A2  RT1-A2_mapped  RT1 class Ia, locus A2 (mapped)  Data merged from RGD:3466 737654 APPROVED
2006-11-20 RT1-A2_mapped  RT1 class Ia, locus A2(mapped)  RT1-A2  RT1 class Ia, locus A2  Symbol set to symbol_mapped, name set to name (mapped) 1582166 APPROVED
2006-11-20 RT1-A2  RT1 class Ia, locus A2      Symbol and Name status set to provisional 70820 PROVISIONAL
2004-02-13 RT1-A2  RT1 class Ia, locus A2  RT1A-2  RT1 class I gene (A-2)  Data merged from RGD:3510 737654 APPROVED
2002-06-10 RT1-A2  RT1 class Ia, locus A2      Symbol and Name status set to approved 70586 APPROVED