Krtap12-4 (keratin associated protein 12-4) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: Krtap12-4 (keratin associated protein 12-4) Rattus norvegicus
Analyze
Symbol: Krtap12-4 (Ensembl: LOC100361664)
Name: keratin associated protein 12-4 (Ensembl:keratin associated protein 12-1-like)
RGD ID: 2319709
Description: Orthologous to several human genes including KRTAP12-2 (keratin associated protein 12-2); INTERACTS WITH benzo[a]pyrene (ortholog); resveratrol (ortholog).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: keratin associated protein 12-1-like; keratin-associated protein 12-1; LOC100361664
RGD Orthologs
Human
Bonobo
Green Monkey
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82010,909,953 - 10,910,285 (-)NCBIGRCr8
mRatBN7.22010,910,350 - 10,910,682 (-)NCBImRatBN7.2mRatBN7.2
UTH_Rnor_SHR_Utx2011,609,869 - 11,610,201 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02010,970,832 - 10,971,164 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02011,442,582 - 11,442,914 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02011,626,503 - 11,627,475 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2011,626,544 - 11,626,876 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02013,792,626 - 13,792,958 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42011,288,955 - 11,289,287 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera2012,412,884 - 12,413,856 (-)NCBICelera
Cytogenetic Map20p12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions

Genomics

Comparative Map Data
Krtap12-4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82010,909,953 - 10,910,285 (-)NCBIGRCr8
mRatBN7.22010,910,350 - 10,910,682 (-)NCBImRatBN7.2mRatBN7.2
UTH_Rnor_SHR_Utx2011,609,869 - 11,610,201 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02010,970,832 - 10,971,164 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02011,442,582 - 11,442,914 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02011,626,503 - 11,627,475 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2011,626,544 - 11,626,876 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02013,792,626 - 13,792,958 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42011,288,955 - 11,289,287 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera2012,412,884 - 12,413,856 (-)NCBICelera
Cytogenetic Map20p12NCBI
KRTAP12-4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382144,654,213 - 44,654,659 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2144,654,213 - 44,654,659 (-)EnsemblGRCh38hg38GRCh38
GRCh372146,074,130 - 46,074,576 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362144,898,558 - 44,899,004 (-)NCBINCBI36Build 36hg18NCBI36
Build 342144,898,557 - 44,899,004NCBI
Celera2131,181,766 - 31,182,212 (-)NCBICelera
Cytogenetic Map21q22.3NCBI
HuRef2131,448,308 - 31,448,754 (-)NCBIHuRef
CHM1_12145,634,978 - 45,635,424 (-)NCBICHM1_1
T2T-CHM13v2.02143,014,666 - 43,015,112 (-)NCBIT2T-CHM13v2.0
LOC134729714
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22240,700,468 - 40,700,914 (-)NCBINHGRI_mPanPan1-v2
LOC119619328
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Vero_WHO_p1.0NW_02366605416,502,256 - 16,502,691 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:40
Count of miRNA genes:38
Interacting mature miRNAs:40
Transcripts:ENSRNOT00000001635
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4889610Pancm3Pancreatic morphology QTL 33.750.001pancreas mass (VT:0010144)pancreas wet weight (CMO:0000626)20418947649189476Rat
2317057Aia27Adjuvant induced arthritis QTL 272.83joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)20126925056Rat
1641915Colcr9Colorectal carcinoma resistance QTL 92.970.0024intestine integrity trait (VT:0010554)benign colorectal tumor number (CMO:0001795)20133724594Rat
4889870Pur30Proteinuria QTL 30190.005urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)20804392029865039Rat
7411668Foco32Food consumption QTL 3280.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)20136600300Rat
2305926Iddm37Insulin dependent diabetes mellitus QTL 376blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)20153308346533083Rat
1354642Despr15Despair related QTL 150.0027locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)20124164241Rat
1558640Prcs2Prostate cancer susceptibility QTL 23.3prostate integrity trait (VT:0010571)percentage of study population developing ventral prostate tumorous lesions during a period of time (CMO:0000943)20134066551Rat
631265Iresp1Immunoglobin response QTL18.3blood anti-double stranded DNA antibody amount (VT:0004762)serum anti-DNA antibody level (CMO:0001533)20904109911115921Rat
8694189Bw153Body weight QTL 1533.130.001body mass (VT:0001259)body weight gain (CMO:0000420)20129193376Rat
4889857Pur27Proteinuria QTL 2712.20.001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)20127341128Rat
1598870Bp289Blood pressure QTL 2892.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)20821635953216359Rat
9590109Sffal8Serum free fatty acids level QTL 85.320.01blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)20129193376Rat
9589155Insul32Insulin level QTL 326.380.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)20129193376Rat
9590275Scort15Serum corticosterone level QTL 153.480.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)20129193376Rat
1581577Pur15Proteinuria QTL 154.380.0002urine total protein amount (VT:0000032)urine protein excretion rate (CMO:0000759)20804392015089182Rat
1598858Cm61Cardiac mass QTL 613.6heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)20821635953216359Rat
7411650Foco23Food consumption QTL 2320.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)20129193376Rat
61432Cia1Collagen induced arthritis QTL 1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)20114100378Rat
2317851Alcrsp22Alcohol response QTL 223.20.05response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)20127341128Rat
1641893Alcrsp7Alcohol response QTL 7response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)20127341128Rat
6893685Bw111Body weight QTL 1112.70.004body mass (VT:0001259)body weight (CMO:0000012)20132578510Rat
9590252Scort12Serum corticosterone level QTL 1220.460.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)20136600300Rat


Expression

RNA-SEQ Expression

appendage
circulatory system
ectoderm
endocrine system
endoderm
integumental system
mesenchyme
mesoderm
nervous system
reproductive system
respiratory system
1 3 7 3 1 1 4 3 6 6 1

Sequence


Ensembl Acc Id: ENSRNOT00000001635   ⟹   ENSRNOP00000001635
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl2011,626,544 - 11,626,876 (-)Ensembl
RefSeq Acc Id: NM_001402162   ⟹   NP_001389091
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82010,909,953 - 10,910,285 (-)NCBI
mRatBN7.22010,910,350 - 10,910,682 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001389091 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL97087 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Acc Id: ENSRNOP00000001635   ⟸   ENSRNOT00000001635
RefSeq Acc Id: NP_001389091   ⟸   NM_001402162
- UniProtKB: A6JK71 (UniProtKB/TrEMBL)

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZUN9-F1-model_v2 AlphaFold D3ZUN9 1-110 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13701500
Promoter ID:EPDNEW_R12021
Type:single initiation site
Name:LOC100361664_1
Description:keratin associated protein 12-1-like
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.02011,626,911 - 11,626,971EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2319709 AgrOrtholog
BioCyc Gene G2FUF-4250 BioCyc
Ensembl Genes ENSRNOG00000001220 Ensembl
InterPro KAP UniProtKB/TrEMBL
NCBI Gene 100361664 ENTREZGENE
Pfam Keratin_B2_2 UniProtKB/TrEMBL
PhenoGen Krtap12-4 PhenoGen
RatGTEx ENSRNOG00000001220 RatGTEx
UniProt A6JK71 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-12-20 Krtap12-4  keratin associated protein 12-4  LOC100361664  keratin associated protein 12-1-like  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2010-05-05 LOC100361664  keratin associated protein 12-1-like      Symbol and Name status set to provisional 70820 PROVISIONAL