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Gene: Lta (lymphotoxin alpha) Rattus norvegicus
Symbol: Lta
Name: lymphotoxin alpha
RGD ID: 3020
Description: Predicted to have cytokine activity and tumor necrosis factor receptor binding activity. Involved in several processes, including negative regulation of fibroblast proliferation; positive regulation of glial cell proliferation; and response to lipopolysaccharide. Localizes to extracellular space. Biomarker of cystitis. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); autoimmune disease (multiple); glucose metabolism disease (multiple); leishmaniasis (multiple); and lung disease (multiple). Orthologous to human LTA (lymphotoxin alpha); PARTICIPATES IN interleukin-4 signaling pathway; cytokine mediated signaling pathway; type 1 diabetes mellitus pathway; INTERACTS WITH 1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane; 2,3,7,8-tetrachlorodibenzodioxine; ammonium chloride.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: LT-alpha; lymphotoxin A; Lymphotoxin alpha (formerly tumor necrosis factor beta); Lymphotoxin alpha (formerly tumor necrosis factor, beta); lymphotoxin alpha (TNF superfamily, member 1); lymphotoxin-alpha; TNF-beta; Tnfb; tumor necrosis factor beta; tumor necrosis factor ligand superfamily member 1
Homo sapiens (human) : LTA (lymphotoxin alpha)  HGNC  Alliance
Mus musculus (house mouse) : Lta (lymphotoxin A)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Lta (lymphotoxin alpha)
Pan paniscus (bonobo/pygmy chimpanzee) : LTA (lymphotoxin alpha)
Canis lupus familiaris (dog) : LTA (lymphotoxin alpha)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Lta (lymphotoxin alpha)
Sus scrofa (pig) : LTA (lymphotoxin alpha)
Heterocephalus glaber (naked mole-rat) : Lta (lymphotoxin alpha)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.0204,851,889 - 4,854,677 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl204,852,496 - 4,854,677 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0206,932,260 - 6,935,077 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4203,657,842 - 3,659,848 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1203,658,068 - 3,660,075 (+)NCBI
Celera204,404,630 - 4,406,751 (-)NCBICelera
Cytogenetic Map20p12NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Candidate Gene Status
Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Lta
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 3020
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2020-08-20
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.