Prmt2 (protein arginine methyltransferase 2)

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Gene: Prmt2 (protein arginine methyltransferase 2) Rattus norvegicus

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Symbol:

Prmt2

Name:

protein arginine methyltransferase 2

RGD ID:

1565519

Description:

Predicted to enable several functions, including beta-catenin binding activity; nuclear receptor binding activity; and protein methyltransferase activity. Predicted to be involved in several processes, including negative regulation of G1/S transition of mitotic cell cycle; regulation of DNA-templated transcription; and regulation of androgen receptor signaling pathway. Predicted to be located in cytosol and nucleoplasm. Predicted to be active in nucleus. Biomarker of asthma. Orthologous to human PRMT2 (protein arginine methyltransferase 2); PARTICIPATES IN histone modification pathway; methionine cycle/metabolic pathway; INTERACTS WITH 1,3-dinitrobenzene; 2,3,7,8-Tetrachlorodibenzofuran; 2,4-dinitrotoluene.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

HMT1 hnRNP methyltransferase-like 1; HMT1 hnRNP methyltransferase-like 1 (S. cerevisiae); Hrmt1l1; LOC102549829; protein arginine N-methyltransferase 2; uncharacterized LOC102549829

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	20	12,391,388 - 12,420,096 (+)	NCBI		GRCr8
mRatBN7.2	20	12,394,748 - 12,420,643 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	20	12,394,798 - 12,420,643 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	20	13,093,643 - 13,119,429 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	20	12,454,567 - 12,480,355 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	20	12,926,352 - 12,952,138 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	20	13,154,513 - 13,212,613 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	20	13,156,241 - 13,212,606 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	20	15,350,261 - 15,366,947 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	20	12,800,400 - 12,817,018 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
Celera	20	13,888,666 - 13,914,342 (+)	NCBI		Celera
Cytogenetic Map	20	p12	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

asthma (IEP)

autistic disorder (ISO)

Axenfeld-Rieger syndrome type 3 (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(-)-demecolcine (ISO)

1,2-dichloroethane (ISO)

1,2-dimethylhydrazine (ISO)

1,3-dinitrobenzene (EXP)

17beta-estradiol (ISO)

2,3,7,8-tetrachlorodibenzodioxine (ISO)

2,3,7,8-Tetrachlorodibenzofuran (EXP)

2,4-dinitrotoluene (EXP)

2-hydroxypropanoic acid (ISO)

3-isobutyl-1-methyl-7H-xanthine (ISO)

4,4'-diaminodiphenylmethane (ISO)

6-propyl-2-thiouracil (EXP)

acetamide (EXP)

all-trans-retinoic acid (EXP,ISO)

amitrole (EXP)

avobenzone (ISO)

benzo[a]pyrene (ISO)

berberine (ISO)

bisphenol A (EXP,ISO)

bisphenol F (ISO)

C60 fullerene (EXP)

cadmium dichloride (EXP)

calcitriol (ISO)

carbon nanotube (ISO)

CGP 52608 (ISO)

chlorpyrifos (ISO)

choline (ISO)

cisplatin (ISO)

cocaine (ISO)

copper(II) sulfate (ISO)

crocidolite asbestos (ISO)

cyclosporin A (ISO)

DDE (ISO)

dexamethasone (ISO)

Dibutyl phosphate (ISO)

dorsomorphin (ISO)

elemental selenium (ISO)

entinostat (ISO)

ethanol (ISO)

folic acid (ISO)

furan (EXP)

geldanamycin (ISO)

hydroquinone O-beta-D-glucopyranoside (ISO)

indometacin (ISO)

ketamine (EXP)

kojic acid (ISO)

L-methionine (ISO)

lead(0) (ISO)

lipopolysaccharide (ISO)

methimazole (EXP)

obeticholic acid (ISO)

paracetamol (ISO)

pirinixic acid (ISO)

rac-lactic acid (ISO)

ribavirin (ISO)

SB 431542 (ISO)

selenium atom (ISO)

silicon dioxide (ISO)

sodium arsenite (ISO)

sunitinib (ISO)

tamibarotene (ISO)

testosterone (ISO)

thioacetamide (EXP)

titanium dioxide (ISO)

triphenyl phosphate (ISO)

triptonide (ISO)

valproic acid (ISO)

vancomycin (ISO)

vinclozolin (EXP)

vitamin E (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

biological_process (ND)

chromatin remodeling (IBA)

methylation (IEA)

negative regulation of DNA-binding transcription factor activity (ISO)

negative regulation of DNA-templated transcription (ISO)

negative regulation of G1/S transition of mitotic cell cycle (ISO)

negative regulation of NF-kappaB transcription factor activity (ISO)

positive regulation of apoptotic process (ISO)

positive regulation of DNA-templated transcription (ISO)

regulation of androgen receptor signaling pathway (ISO)

regulation of DNA-templated transcription (IBA)

response to hypoxia (ISO)

Cellular Component

cytoplasm (ISO)

cytosol (ISO)

nucleoplasm (ISO)

nucleus (IBA,ISO)

Molecular Function

beta-catenin binding (ISO)

histone H3 methyltransferase activity (ISO)

histone methyltransferase activity (IBA,ISO)

nuclear androgen receptor binding (ISO)

nuclear estrogen receptor binding (ISO)

nuclear progesterone receptor binding (ISO)

nuclear retinoic acid receptor binding (ISO)

nuclear thyroid hormone receptor binding (ISO)

peroxisome proliferator activated receptor binding (ISO)

protein binding (ISO)

protein homodimerization activity (ISO)

protein-arginine N-methyltransferase activity (IBA,ISO)

protein-containing complex binding (ISO)

transcription coactivator activity (ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

histone modification pathway (ISO)

methionine cycle/metabolic pathway (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Histone arginine methylation.	Di Lorenzo A and Bedford MT, FEBS Lett. 2011 Jul 7;585(13):2024-31. doi: 10.1016/j.febslet.2010.11.010. Epub 2010 Nov 11.
2.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3.	Readers of histone methylarginine marks.	Gayatri S and Bedford MT, Biochim Biophys Acta. 2014 Aug;1839(8):702-710. doi: 10.1016/j.bbagrm.2014.02.015. Epub 2014 Feb 28.
4.	GOA pipeline	RGD automated data pipeline
5.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
6.	Comprehensive gene review and curation	RGD comprehensive gene curation
7.	Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.	Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
8.	[Expression of protein arginine N-methyltransferases in E3 rat models of acute asthma].	Sun QZ, etal., Nan Fang Yi Ke Da Xue Xue Bao. 2010 Apr;30(4):716-9.

Additional References at PubMed

PMID:11513728	PMID:12039952	PMID:16616919	PMID:16648481	PMID:16690984	PMID:17587566	PMID:19405910	PMID:20708585	PMID:20798359	PMID:38561150

Genomics

Comparative Map Data

Prmt2
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	20	12,391,388 - 12,420,096 (+)	NCBI		GRCr8
mRatBN7.2	20	12,394,748 - 12,420,643 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	20	12,394,798 - 12,420,643 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	20	13,093,643 - 13,119,429 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	20	12,454,567 - 12,480,355 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	20	12,926,352 - 12,952,138 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	20	13,154,513 - 13,212,613 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	20	13,156,241 - 13,212,606 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	20	15,350,261 - 15,366,947 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	20	12,800,400 - 12,817,018 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
Celera	20	13,888,666 - 13,914,342 (+)	NCBI		Celera
Cytogenetic Map	20	p12	NCBI

PRMT2
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	21	46,635,674 - 46,665,124 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	21	46,635,595 - 46,665,685 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	21	48,055,586 - 48,085,036 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	21	46,879,955 - 46,909,291 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Celera	21	33,168,696 - 33,198,017 (+)	NCBI		Celera
Cytogenetic Map	21	q22.3	NCBI
HuRef	21	33,435,442 - 33,465,194 (+)	NCBI		HuRef
CHM1_1	21	47,616,361 - 47,646,003 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	21	45,021,936 - 45,051,495 (+)	NCBI		T2T-CHM13v2.0

Prmt2
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	10	76,043,060 - 76,073,699 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	10	76,043,056 - 76,073,699 (-)	Ensembl		GRCm39 Ensembl
GRCm38	10	76,207,226 - 76,237,865 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	10	76,207,222 - 76,237,865 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	10	75,669,967 - 75,700,610 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	10	75,650,945 - 75,681,491 (-)	NCBI		MGSCv36	mm8
Celera	10	77,251,152 - 77,281,794 (-)	NCBI		Celera
Cytogenetic Map	10	C1	NCBI
cM Map	10	38.74	NCBI

Prmt2
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955407	42,992,469 - 43,018,760 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955407	42,991,305 - 43,019,332 (+)	NCBI	ChiLan1.0	ChiLan1.0

PRMT2
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	22	42,816,850 - 42,846,435 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	21	37,626,465 - 37,656,054 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	21	33,100,101 - 33,130,060 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	21	46,233,951 - 46,263,570 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	21	46,233,951 - 46,263,570 (+)	Ensembl	panpan1.1		panPan2

PRMT2
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	31	39,806,086 - 39,838,959 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	31	39,807,593 - 39,838,972 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	31	39,035,200 - 39,063,238 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	31	39,448,681 - 39,482,537 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	31	39,448,738 - 39,482,534 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	31	39,309,961 - 39,343,796 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	31	39,270,792 - 39,304,601 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	31	39,789,053 - 39,822,809 (+)	NCBI		UU_Cfam_GSD_1.0

Prmt2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404971	39,098,966 - 39,117,221 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936778	12,967 - 29,077 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936778	12,988 - 31,217 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

PRMT2
(Sus scrofa - pig)

No map positions available.

PRMT2
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	2	90,225,051 - 90,256,541 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	2	90,225,346 - 90,256,558 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666054	18,648,120 - 18,679,648 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Prmt2
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624745	31,689,868 - 31,709,018 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624745	31,680,149 - 31,701,322 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Prmt2
286 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	67
Count of miRNA genes:	63
Interacting mature miRNAs:	65
Transcripts:	ENSRNOT00000050531
Prediction methods:	Miranda, Rnahybrid
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
4889870	Pur30	Proteinuria QTL 30	19	0.005	urine total protein amount (VT:0000032)	urine total protein excretion rate (CMO:0000756)	20	8042410	29322208	Rat
1354642	Despr15	Despair related QTL 15		0.0027	locomotor behavior trait (VT:0001392)	amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)	20	1	24159021	Rat
4889857	Pur27	Proteinuria QTL 27	12.2	0.001	urine total protein amount (VT:0000032)	urine total protein excretion rate (CMO:0000756)	20	4606607	17617956	Rat
70154	Insul2	Insulin level QTL 2	3.75		blood insulin amount (VT:0001560)	plasma insulin level (CMO:0000342)	20	6691706	17489458	Rat
9590109	Sffal8	Serum free fatty acids level QTL 8	5.32	0.01	blood free fatty acid amount (VT:0001553)	plasma free fatty acids level (CMO:0000546)	20	1	29191651	Rat
9590275	Scort15	Serum corticosterone level QTL 15	3.48	0.001	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	20	1	29191651	Rat
1581577	Pur15	Proteinuria QTL 15	4.38	0.0002	urine total protein amount (VT:0000032)	urine protein excretion rate (CMO:0000759)	20	8042410	17617956	Rat
6893685	Bw111	Body weight QTL 111	2.7	0.004	body mass (VT:0001259)	body weight (CMO:0000012)	20	1	32578807	Rat
9590092	Insglur9	Insulin/glucose ratio QTL 9	18.38	0.001	blood insulin amount (VT:0001560)	calculated plasma insulin level (CMO:0002170)	20	11757515	54435887	Rat
1641915	Colcr9	Colorectal carcinoma resistance QTL 9	2.97	0.0024	intestine integrity trait (VT:0010554)	benign colorectal tumor number (CMO:0001795)	20	1530655	46530655	Rat
2317057	Aia27	Adjuvant induced arthritis QTL 27	2.83		joint integrity trait (VT:0010548)	right rear ankle joint diameter (CMO:0002150)	20	2892597	26381954	Rat
7387283	Uae44	Urinary albumin excretion QTL 44		0.1712	urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	20	1	26123605	Rat
7411668	Foco32	Food consumption QTL 32	8	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	20	1	36600972	Rat
2305926	Iddm37	Insulin dependent diabetes mellitus QTL 37	6		blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	20	1527842	46527842	Rat
1600382	Edcs3	Endometrial carcinoma susceptibility QTL3	3.5	0.003	uterus morphology trait (VT:0001120)	percentage of study population developing endometrioid carcinoma during a period of time (CMO:0001759)	20	1	25159026	Rat
1558640	Prcs2	Prostate cancer susceptibility QTL 2	3.3		prostate integrity trait (VT:0010571)	percentage of study population developing ventral prostate tumorous lesions during a period of time (CMO:0000943)	20	4606607	17617956	Rat
631265	Iresp1	Immunoglobin response QTL1	8.3		blood anti-double stranded DNA antibody amount (VT:0004762)	serum anti-DNA antibody level (CMO:0001533)	20	9039719	13461775	Rat
8694189	Bw153	Body weight QTL 153	3.13	0.001	body mass (VT:0001259)	body weight gain (CMO:0000420)	20	1	29191651	Rat
9589155	Insul32	Insulin level QTL 32	6.38	0.001	blood insulin amount (VT:0001560)	plasma insulin level (CMO:0000342)	20	1	29191651	Rat
7411650	Foco23	Food consumption QTL 23	20.7	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	20	1	29191651	Rat
7411652	Foco24	Food consumption QTL 24		0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	20	11757515	54435887	Rat
2317851	Alcrsp22	Alcohol response QTL 22	3.2	0.05	response to alcohol trait (VT:0010489)	duration of loss of righting reflex (CMO:0002289)	20	1	27339237	Rat
1598816	Memor12	Memory QTL 12	2.4		exploratory behavior trait (VT:0010471)	average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)	20	2606836	47606836	Rat
61432	Cia1	Collagen induced arthritis QTL 1			joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	20	3621656	14101050	Rat
1641893	Alcrsp7	Alcohol response QTL 7			response to alcohol trait (VT:0010489)	duration of loss of righting reflex (CMO:0002289)	20	1	27339237	Rat
9590252	Scort12	Serum corticosterone level QTL 12	20.46	0.001	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	20	1	36600972	Rat

Markers in Region

RH136932

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	20	12,395,821 - 12,396,234 (+)	MAPPER	mRatBN7.2
Rnor_6.0	20	13,157,206 - 13,157,618	NCBI	Rnor6.0
Rnor_5.0	20	15,310,043 - 15,310,455	UniSTS	Rnor5.0
Celera	20	13,889,631 - 13,890,043	UniSTS
RH 3.4 Map	20	179.27	UniSTS
Cytogenetic Map	20	p12	UniSTS

AA945753

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	20	12,420,339 - 12,420,435 (+)	MAPPER	mRatBN7.2
Rnor_6.0	20	13,212,310 - 13,212,405	NCBI	Rnor6.0
Rnor_5.0	20	15,366,644 - 15,366,739	UniSTS	Rnor5.0
RGSC_v3.4	20	12,816,715 - 12,816,810	UniSTS	RGSC3.4
Celera	20	13,914,039 - 13,914,134	UniSTS
Cytogenetic Map	20	p12	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	nervous system	renal system	reproductive system	respiratory system
9	11	49	113	91	90	59	25	59	6	218	97	93	45	60	31

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001025144	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039099009	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039099010	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063279461	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063279462	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063279463	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XR_597356	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	BC079112	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473988	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000020	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000050531 ⟹ ENSRNOP00000039976

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	20	12,394,798 - 12,420,643 (+)	Ensembl
Rnor_6.0 Ensembl	20	13,156,241 - 13,212,606 (+)	Ensembl

RefSeq Acc Id:

NM_001025144 ⟹ NP_001020315

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	20	12,394,315 - 12,420,096 (+)	NCBI
mRatBN7.2	20	12,394,857 - 12,420,643 (+)	NCBI
Rnor_6.0	20	13,156,241 - 13,212,613 (+)	NCBI
Rnor_5.0	20	15,350,261 - 15,366,947 (+)	NCBI
RGSC_v3.4	20	12,800,400 - 12,817,018 (+)	RGD
Celera	20	13,888,666 - 13,914,342 (+)	RGD

Sequence:

show sequence

CTGTTCCTTTCTGGGCTAGCCTAGAATTCAGCGGAGAAACGCGGCTGAGACGTGATGAGAAGAT
GAAGTGAGGCACCAGTTATGAGACATGAGCTTACTGAACTATGGAGGCACCAGCTGAAGATCCC
AGCCATGAGTCACAGGTCACCCCAGCTCCGGAGGAAGACCCTGTGGACTATGGCTGTGAGATGC
AGCTCCTTCAGGACGGGGCACAGTTGCAGCTGCAGCTGCAGCCCGAGGAGTTCGTAGCCATTGC
AGATTACACCGCCACCGACGAGACACAGCTCAGCTTTCTGAGAGGAGAAAAAATTCTGATCCTG
AGGCAAACCACGGCGGACTGGTGGTGGGGCGAACGTGCGGGCTGCTGCGGGTACATCCCCGCAA
ACCACCTTGGGAAGCAGGTGGAGGAGTACGACCCGGAGGACACCTGGCAAGATGAGGAGTACTT
CGACAGCTATGGGACTCTGAAACTTCACCTGGAAATGTTGGCTGACCAGCCTCGGACAACCAAG
TACCACAGTGTCATCCTGCAGAACAAGGAGTCTCTGAAGGACAAGGTCATACTGGATGTGGGCT
GCGGCACCGGCATCATCAGCCTTTTCTGCGCTCATCATGCCCGGCCCAAGGCAGTGTACGCGGT
AGAAGCCAGTGACATGGCCCAGCACACGGGCCAGCTGGTCCTGCAGAATGGCTTTGCTGACACA
ATCACTGTGTTTCAGCAGAAGGTGGAGGACGTGGTGTTGCCCGAGAAGGTGGACGTGCTGGTGT
CGGAGTGGATGGGGACCTGTCTCTTGTTTGAGTTCATGATCGAGTCCATCCTGTACGCCCGGGA
TGCCTGGTTAAAGGAAGATGGCATCATTTGGCCAACCACGGCGGCACTGCACTTGGTACCCTGC
AGCGCTGAGAAAGACTACCACAGCAAGGTGCTCTTCTGGGACAACGCGTACGAGTTCAACCTCA
GTGCACTCAAGTCGTTAGCAATCAAGGAGTTCTTTTCAAGGCCAAAGTCTAATCATATCTTGAA
GCCAGAAGACTGCCTCTCTGAGCCATGCACAATATTGCAGTTGGACATGAGAACTGTGCAGGTC
TCTGACCTGGAGACCATGCGTGGCGAGCTGCGATTTGACATCCAAAAGGCTGGGACCCTGCATG
GCTTCACAGCTTGGTTCAGTGTACATTTCCAGAGCCTGGAGGAGGGCCAGCCTCAGCAGGTTCT
CAGCACAGGACCGCTGCACCCCACCACACACTGGAAGCAGACCTTGTTTATGATGGACGACCCA
GTCCCAGTCCACACAGGAGACGTGGTCACGGGTTCGGTGGTGTTACAGAGAAATCCGGTGTGGA
GAAGGCACATGTCCGTCTGTCTGAGCTGGGTCGTCACTTCCGCAGTTGATCCCACGTCTCAAAG
GGCTGGAGAGAAAGTCTTTCCGATCTGGAGGTGACGGTTAAGCACCGCGTGGGAGTCACGGCCG
TGGTGTGCATCTTGGTGGAAGAAGATGCGTCTGGCCACCTTCTGTGACGTACACACTCACCCGT
CCCATGCTGACCCCTTCCCACCCAGCAGGTGACATCGGGCCCCTCACAGCTCACCCCCCAACCC
CCAGTGTCATTTCTCCCGTAGGCTGTGTATATATATAGGTGTTCATCCTGTGGTGCCCGTCGCT
GCCAGCCGTGTTCCCAGCCGGGAGTAGTTGTAGATCCCTCAGACACACATTTCAGCCTGTGTAC
CTGTGACTGTGATGTCCACACCTTGTGTCAGTGGTGTCCTTGATGCCCTCGACCAGCTGCTGCA
CCTGTGGACTGTGGCTTGCCGAGCCGTGCTCCGGTATGAGAGATGGCCGAGCACCCGTGTCTCG
GGGCAAGGACTGGAGGTGGCAGCGTGCGCAGTGGGCTCTGCATGGGTAGCCGCGTGTAACGTCT
TATGGGTAAATTATATGTGGGGCATAGTACATGCTCAATAAATATTTTTTAATGAACAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAA

hide sequence

RefSeq Acc Id:

XM_039099009 ⟹ XP_038954937

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	20	12,394,383 - 12,420,096 (+)	NCBI
mRatBN7.2	20	12,394,921 - 12,420,643 (+)	NCBI

RefSeq Acc Id:

XM_039099010 ⟹ XP_038954938

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	20	12,394,383 - 12,420,096 (+)	NCBI
mRatBN7.2	20	12,395,375 - 12,420,643 (+)	NCBI

RefSeq Acc Id:

XM_063279461 ⟹ XP_063135531

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	20	12,391,388 - 12,420,096 (+)	NCBI

RefSeq Acc Id:

XM_063279462 ⟹ XP_063135532

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	20	12,394,379 - 12,420,096 (+)	NCBI

RefSeq Acc Id:

XM_063279463 ⟹ XP_063135533

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	20	12,394,743 - 12,420,096 (+)	NCBI

Protein Sequences


Protein RefSeqs	NP_001020315	(Get FASTA)	NCBI Sequence Viewer
	XP_038954937	(Get FASTA)	NCBI Sequence Viewer
	XP_038954938	(Get FASTA)	NCBI Sequence Viewer
	XP_063135531	(Get FASTA)	NCBI Sequence Viewer
	XP_063135532	(Get FASTA)	NCBI Sequence Viewer
	XP_063135533	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAH79112	(Get FASTA)	NCBI Sequence Viewer
	EDL97157	(Get FASTA)	NCBI Sequence Viewer
	EDL97158	(Get FASTA)	NCBI Sequence Viewer
	EDL97159	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000039976.3

RefSeq Acc Id:

NP_001020315 ⟸ NM_001025144

- UniProtKB:

Q6AYB9 (UniProtKB/TrEMBL), F1LMD8 (UniProtKB/TrEMBL), A0A9K3Y6N8 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MEAPAEDPSHESQVTPAPEEDPVDYGCEMQLLQDGAQLQLQLQPEEFVAIADYTATDETQLSFL
RGEKILILRQTTADWWWGERAGCCGYIPANHLGKQVEEYDPEDTWQDEEYFDSYGTLKLHLEML
ADQPRTTKYHSVILQNKESLKDKVILDVGCGTGIISLFCAHHARPKAVYAVEASDMAQHTGQLV
LQNGFADTITVFQQKVEDVVLPEKVDVLVSEWMGTCLLFEFMIESILYARDAWLKEDGIIWPTT
AALHLVPCSAEKDYHSKVLFWDNAYEFNLSALKSLAIKEFFSRPKSNHILKPEDCLSEPCTILQ
LDMRTVQVSDLETMRGELRFDIQKAGTLHGFTAWFSVHFQSLEEGQPQQVLSTGPLHPTTHWKQ
TLFMMDDPVPVHTGDVVTGSVVLQRNPVWRRHMSVCLSWVVTSAVDPTSQRAGEKVFPIWR

hide sequence

Ensembl Acc Id:

ENSRNOP00000039976 ⟸ ENSRNOT00000050531

RefSeq Acc Id:	XP_038954937 ⟸ XM_039099009
- Peptide Label:	isoform X2
- UniProtKB:	F1LMD8 (UniProtKB/TrEMBL), Q6AYB9 (UniProtKB/TrEMBL), A0A9K3Y6N8 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038954938 ⟸ XM_039099010
- Peptide Label:	isoform X2
- UniProtKB:	F1LMD8 (UniProtKB/TrEMBL), Q6AYB9 (UniProtKB/TrEMBL), A0A9K3Y6N8 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_063135531 ⟸ XM_063279461
- Peptide Label:	isoform X1

RefSeq Acc Id:	XP_063135532 ⟸ XM_063279462
- Peptide Label:	isoform X1

RefSeq Acc Id:	XP_063135533 ⟸ XM_063279463
- Peptide Label:	isoform X1

Protein Domains

SH3

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q6AYB9-F1-model_v2	AlphaFold	Q6AYB9	1-445	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13701521

Promoter ID:

EPDNEW_R12045

Type:

multiple initiation site

Name:

Prmt2_1

Description:

protein arginine methyltransferase 2

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	20	13,156,202 - 13,156,262	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1565519	AgrOrtholog
BioCyc Gene	G2FUF-4182	BioCyc
Ensembl Genes	ENSRNOG00000001297	Ensembl, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000050531.4	UniProtKB/TrEMBL
Gene3D-CATH	3.40.50.150	UniProtKB/TrEMBL
	Hnrnp arginine n-methyltransferase1	UniProtKB/TrEMBL
	SH3 Domains	UniProtKB/TrEMBL
IMAGE_CLONE	IMAGE:7125748	IMAGE-MGC_LOAD
InterPro	Arg_MeTrfase	UniProtKB/TrEMBL
	PRMT_dom	UniProtKB/TrEMBL
	SAM-dependent_MTases-like	UniProtKB/TrEMBL
	SH3-like_dom	UniProtKB/TrEMBL
	SH3_domain	UniProtKB/TrEMBL
	Small_mtfrase_dom	UniProtKB/TrEMBL
KEGG Report	rno:499420	UniProtKB/TrEMBL
MGC_CLONE	MGC:94107	IMAGE-MGC_LOAD
NCBI Gene	499420	ENTREZGENE
PANTHER	PROTEIN ARGININE N-METHYLTRANSFERASE 2	UniProtKB/TrEMBL
	PTHR11006	UniProtKB/TrEMBL
Pfam	MTS	UniProtKB/TrEMBL
	PRMT_C	UniProtKB/TrEMBL
	SH3_1	UniProtKB/TrEMBL
PhenoGen	Prmt2	PhenoGen
PRINTS	SH3DOMAIN	UniProtKB/TrEMBL
PROSITE	SAM_MT_PRMT	UniProtKB/TrEMBL
	SH3	UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000001297	RatGTEx
SMART	SH3	UniProtKB/TrEMBL
Superfamily-SCOP	SH3	UniProtKB/TrEMBL
	SSF53335	UniProtKB/TrEMBL
UniProt	A0A9K3Y6N8	ENTREZGENE, UniProtKB/TrEMBL
	F1LMD8	ENTREZGENE
	Q6AYB9	ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary	F1LMD8	UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2015-07-29	Prmt2	protein arginine methyltransferase 2	LOC102549829	uncharacterized LOC102549829	Data merged from RGD:7748611	737654	PROVISIONAL
2013-12-18	LOC102549829	uncharacterized LOC102549829			Symbol and Name status set to provisional	70820	PROVISIONAL
2008-10-24	Prmt2	protein arginine methyltransferase 2	Prmt2	protein arginine N-methyltransferase 2	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-03-04	Prmt2	protein arginine N-methyltransferase 2	Hrmt1l1	HMT1 hnRNP methyltransferase-like 1 (S. cerevisiae)	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2006-02-09	Hrmt1l1	HMT1 hnRNP methyltransferase-like 1 (S. cerevisiae)			Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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