Gene: Gstt2 (glutathione S-transferase, theta 2) Rattus norvegicus
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Symbol:
Gstt2
Name:
glutathione S-transferase, theta 2
Description:
Exhibits glutathione peroxidase activity and glutathione transferase activity. Involved in glutathione metabolic process and response to salicylic acid. Localizes to the cytosol and nucleus. Biomarker of Charcot-Marie-Tooth disease. Orthologous to several human genes including GSTT2 (glutathione S-transferase theta 2 (gene/pseudogene)); PARTICIPATES IN glutathione conjugation pathway; glutathione metabolic pathway; phase I biotransformation pathway via cytochrome P450; INTERACTS WITH (+)-schisandrin B; 1-chloro-2,4-dinitrobenzene; 17beta-estradiol.
Type:
protein-coding
RefSeq Status:
VALIDATED
Also known as:
glutathione S-transferase 12; glutathione S-transferase theta-2; glutathione S-transferase Yrs-Yrs; GST 12-12; GST class-theta-2
Orthologs:
Species
Gene symbol and name
Data Source
Assertion derived from
less info ...
Orthologs 1
Homo sapiens (human):
GSTT2 (glutathione S-transferase theta 2 (gene/pseudogene)) HGNC
Ensembl, HomoloGene, Inparanoid, Panther, PhylomeDB
Mus musculus (house mouse):
Gstt2 (glutathione S-transferase, theta 2) HGNC
HomoloGene, Panther, Ensembl
Other homologs 2
Homo sapiens (human):
GSTT2B (glutathione S-transferase theta 2B (gene/pseudogene)) HGNC
Ensembl, HomoloGene, OMA, OrthoDB, Panther
Alliance orthologs 3
Mus musculus (house mouse):
Gstt2 (glutathione S-transferase, theta 2)
Alliance
DIOPT (Ensembl Compara, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB)
Homo sapiens (human):
GSTT2 (glutathione S-transferase theta 2 (gene/pseudogene))
Alliance
DIOPT (Ensembl Compara, HGNC, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB)
Homo sapiens (human):
GSTT2B (glutathione S-transferase theta 2B (gene/pseudogene))
Alliance
DIOPT (Ensembl Compara, OMA, OrthoFinder, PANTHER)
Danio rerio (zebrafish):
gstt1b (glutathione S-transferase theta 1b)
Alliance
DIOPT (Ensembl Compara, OrthoFinder, PANTHER, PhylomeDB)
Danio rerio (zebrafish):
gstt1a (glutathione S-transferase theta 1a)
Alliance
DIOPT (Ensembl Compara, OrthoFinder, PANTHER, PhylomeDB)
Drosophila melanogaster (fruit fly):
GstT1
Alliance
DIOPT (Ensembl Compara, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB)
Drosophila melanogaster (fruit fly):
GstT2
Alliance
DIOPT (Ensembl Compara, InParanoid, OMA, OrthoFinder, PANTHER, PhylomeDB)
Drosophila melanogaster (fruit fly):
GstT3
Alliance
DIOPT (Ensembl Compara, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB)
Drosophila melanogaster (fruit fly):
GstT4
Alliance
DIOPT (Ensembl Compara, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB)
Saccharomyces cerevisiae (baker's yeast):
URE2
Alliance
DIOPT (Hieranoid, OrthoFinder)
Latest Assembly:
Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl Rnor_6.0 20 13,760,810 - 13,764,481 (+) NCBI Rnor6.0 Rnor_6.0 rn6 Rnor6.0 Rnor_6.0 Ensembl 20 13,760,810 - 13,764,475 (+) Ensembl Rnor_5.0 20 15,913,944 - 15,917,615 (+) NCBI Rnor5.0 Rnor_5.0 rn5 Rnor5.0 RGSC_v3.4 20 13,221,696 - 13,225,367 (+) NCBI RGSC3.4 rn4 RGSC3.4 RGSC_v3.1 20 13,221,934 - 13,225,575 (+) NCBI Celera 20 14,311,251 - 14,314,818 (+) NCBI Celera Cytogenetic Map 20 p12 NCBI
JBrowse:
View Region in Genome Browser (JBrowse)
Model
Disease Annotations
Imported Annotations - ClinVar
schizophrenia ISO RGD:1349485 8554872 ClinVar Annotator: match by term: Schizophrenia ClinVar PMID:21681106 , PMID:30208311
Imported Annotations - CTD
facioscapulohumeral muscular dystrophy ISO RGD:1349485 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:12868502 hypertension ISO RGD:1349485 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:22228705
(+)-schisandrin B multiple interactions EXP 6480464 schizandrin B inhibits the reaction [Carbon Tetrachloride results in decreased expression of GSTT2 mRNA] CTD PMID:31150632 1-chloro-2,4-dinitrobenzene increases metabolic processing EXP 6480464 GSTT2 protein results in increased metabolism of Dinitrochlorobenzene CTD PMID:12054768 17beta-estradiol decreases expression ISO RGD:1349485 6480464 Estradiol results in decreased expression of GSTT2 mRNA CTD PMID:17982697 17beta-estradiol multiple interactions EXP 6480464 [bisphenol A co-treated with Estradiol] results in decreased expression of GSTT2 mRNA CTD PMID:26496021 2,3,7,8-tetrachlorodibenzodioxine decreases expression EXP 6480464 Tetrachlorodibenzodioxin results in decreased expression of GSTT2 mRNA CTD PMID:21215274 2,3,7,8-tetrachlorodibenzodioxine affects expression EXP 6480464 Tetrachlorodibenzodioxin affects the expression of GSTT2 mRNA CTD PMID:22298810 2-hydroxypropanoic acid decreases expression ISO RGD:1349485 6480464 Lactic Acid results in decreased expression of GSTT2 mRNA CTD PMID:30851411 3-chloropropane-1,2-diol decreases expression EXP 6480464 alpha-Chlorohydrin analog results in decreased expression of GSTT2 protein CTD PMID:26597043 3H-1,2-dithiole-3-thione increases expression EXP 6480464 1, 2-dithiol-3-thione results in increased expression of GSTT2 mRNA CTD PMID:19162173 6-propyl-2-thiouracil decreases expression EXP 6480464 Propylthiouracil results in decreased expression of GSTT2 mRNA CTD PMID:24780913 acetylsalicylic acid increases expression EXP 6480464 Aspirin results in increased expression of GSTT2 protein CTD PMID:9729437 aflatoxin B1 increases expression ISO RGD:1349485 6480464 Aflatoxin B1 results in increased expression of GSTT2 mRNA CTD PMID:21641981 aflatoxin B1 increases methylation ISO RGD:1349485 6480464 Aflatoxin B1 results in increased methylation of GSTT2 gene CTD PMID:27153756 aflatoxin B1 multiple interactions EXP 6480464 GSTT2 protein affects the metabolism of and results in increased oxidation of Aflatoxin B1 CTD PMID:8951341 ammonium chloride affects expression EXP 6480464 Ammonium Chloride affects the expression of GSTT2 mRNA CTD PMID:16483693 artesunate affects response to substance ISO RGD:1349485 6480464 GSTT2 mRNA affects the susceptibility to artesunate CTD PMID:15796179 benzo[a]pyrene increases expression ISO RGD:1349485 6480464 Benzo(a)pyrene results in increased expression of GSTT2 mRNA CTD PMID:21714911 bisphenol A multiple interactions EXP 6480464 [bisphenol A co-treated with Estradiol] results in decreased expression of GSTT2 mRNA CTD PMID:26496021 bisphenol A increases expression EXP 6480464 bisphenol A results in increased expression of GSTT2 mRNA CTD PMID:25181051 bosentan decreases expression ISO RGD:1349485 6480464 Bosentan results in decreased expression of GSTT2 mRNA CTD PMID:29761207 buspirone increases expression EXP 6480464 Buspirone results in increased expression of GSTT2 mRNA CTD PMID:24136188 chlorpyrifos increases expression EXP 6480464 Chlorpyrifos results in increased expression of GSTT2 mRNA CTD PMID:19440498 cisplatin increases expression EXP 6480464 Cisplatin results in increased expression of GSTT2 mRNA CTD PMID:22023808 copper atom decreases expression EXP 6480464 Copper results in decreased expression of GSTT2 mRNA CTD PMID:22465980 copper(0) decreases expression EXP 6480464 Copper results in decreased expression of GSTT2 mRNA CTD PMID:22465980 copper(II) sulfate decreases expression ISO RGD:1349485 6480464 Copper Sulfate results in decreased expression of GSTT2 mRNA CTD PMID:19549813 cumene hydroperoxide affects metabolic processing EXP 6480464 GSTT2 protein affects the metabolism of cumene hydroperoxide CTD PMID:2114406 Deoxycorticosterone acetate multiple interactions EXP 6480464 [Desoxycorticosterone Acetate co-treated with Sodium Chloride, Dietary co-treated with Potassium Chloride] results in decreased expression of GSTT2 mRNA CTD PMID:22228705 diazinon increases expression EXP 6480464 Diazinon results in increased expression of GSTT2 mRNA CTD PMID:19440498 dichlorine multiple interactions EXP 6480464 [Ozone co-treated with Chlorine] results in increased expression of GSTT2 mRNA CTD PMID:18636392 doxorubicin increases expression EXP 6480464 Doxorubicin results in increased expression of GSTT2 mRNA CTD PMID:19915844 etacrynic acid affects metabolic processing EXP 6480464 GSTT2 protein affects the metabolism of Ethacrynic Acid CTD PMID:2114406 etoposide affects response to substance ISO RGD:1349485 6480464 GSTT2 protein affects the susceptibility to Etoposide CTD PMID:16217747 fipronil decreases expression EXP 6480464 fipronil results in decreased expression of GSTT2 mRNA CTD PMID:23962444 flavonoids decreases expression EXP 6480464 Flavonoids results in decreased expression of GSTT2 mRNA CTD PMID:18035473 flutamide increases expression EXP 6480464 Flutamide results in increased expression of GSTT2 mRNA CTD PMID:24793618 glafenine decreases expression EXP 6480464 Glafenine results in decreased expression of GSTT2 mRNA CTD PMID:24136188 herbicide multiple interactions EXP 6480464 Herbicides binds to and results in decreased activity of GSTT2 protein CTD PMID:6686184 hydralazine multiple interactions ISO RGD:1349485 6480464 [Hydralazine co-treated with Valproic Acid] results in increased expression of GSTT2 mRNA CTD PMID:17183730 ibuprofen increases expression EXP 6480464 Ibuprofen results in increased expression of GSTT2 protein CTD PMID:9729437 indometacin increases expression EXP 6480464 Indomethacin results in increased expression of GSTT2 protein CTD PMID:9729437 microcystin decreases expression EXP 6480464 Microcystins results in decreased expression of GSTT2 mRNA CTD PMID:19790251 microcystin affects expression EXP 6480464 Microcystins affects the expression of GSTT2 mRNA CTD PMID:19790251 mifepristone decreases expression ISO RGD:1349485 6480464 Mifepristone results in decreased expression of GSTT2 mRNA CTD PMID:17584828 N-acetyl-beta-D-glucosamine increases expression ISO RGD:1349485 6480464 Acetylglucosamine results in increased expression of GSTT2 mRNA CTD PMID:18047607 N-acetyl-D-glucosamine increases expression ISO RGD:1349485 6480464 Acetylglucosamine results in increased expression of GSTT2 mRNA CTD PMID:18047607 N-nitrosodiethylamine multiple interactions EXP 6480464 caffeic acid phenethyl ester inhibits the reaction [Diethylnitrosamine results in increased expression of GSTT2 mRNA] CTD PMID:20360939 N-nitrosodiethylamine increases expression EXP 6480464 Diethylnitrosamine results in increased expression of GSTT2 mRNA CTD PMID:20360939 ochratoxin A decreases expression EXP 6480464 ochratoxin A results in decreased expression of GSTT2 mRNA CTD PMID:16251485 more ... oxybenzone increases expression EXP 6480464 oxybenzone results in increased expression of GSTT2 mRNA CTD PMID:30316929 ozone multiple interactions EXP 6480464 [Ozone co-treated with Chlorine] results in increased expression of GSTT2 mRNA CTD PMID:18636392 paracetamol increases expression ISO RGD:1349485 6480464 Acetaminophen results in increased expression of GSTT2 mRNA CTD PMID:26690555 paraoxon increases expression ISO RGD:1349485 6480464 Paraoxon results in increased expression of GSTT2 CTD PMID:24486155 paraquat increases expression EXP 6480464 Paraquat results in increased expression of GSTT2 protein CTD PMID:24521700 parathion increases expression ISO RGD:1349485 6480464 Parathion results in increased expression of GSTT2 mRNA CTD PMID:17982697 phenethyl caffeate multiple interactions EXP 6480464 caffeic acid phenethyl ester inhibits the reaction [Diethylnitrosamine results in increased expression of GSTT2 mRNA] CTD PMID:20360939 phenobarbital decreases expression EXP 6480464 Phenobarbital results in decreased expression of GSTT2 mRNA CTD PMID:19162173 phlorizin decreases expression ISO RGD:737512 6480464 Phlorhizin results in decreased expression of GSTT2B mRNA CTD PMID:22538082 potassium chloride multiple interactions EXP 6480464 [Desoxycorticosterone Acetate co-treated with Sodium Chloride, Dietary co-treated with Potassium Chloride] results in decreased expression of GSTT2 mRNA CTD PMID:22228705 progesterone increases expression EXP 6480464 Progesterone results in increased expression of GSTT2 mRNA CTD PMID:20726854 rac-lactic acid decreases expression ISO RGD:1349485 6480464 Lactic Acid results in decreased expression of GSTT2 mRNA CTD PMID:30851411 sarin decreases expression ISO RGD:1349485 6480464 Sarin results in decreased expression of GSTT2 mRNA CTD PMID:19522546 T-2 Toxin increases expression EXP 6480464 T-2 Toxin results in increased expression of GSTT2 mRNA CTD PMID:26141394 tetrachloromethane decreases expression EXP 6480464 Carbon Tetrachloride results in decreased expression of GSTT2 mRNA CTD PMID:16644059 , PMID:31150632 tetrachloromethane multiple interactions EXP 6480464 schizandrin B inhibits the reaction [Carbon Tetrachloride results in decreased expression of GSTT2 mRNA] CTD PMID:31150632 Tributyltin oxide increases expression ISO RGD:1349485 6480464 bis(tri-n-butyltin)oxide results in increased expression of GSTT2 mRNA CTD PMID:21601586 valproic acid multiple interactions ISO RGD:1349485 6480464 [Hydralazine co-treated with Valproic Acid] results in increased expression of GSTT2 mRNA CTD PMID:17183730 valproic acid increases methylation ISO RGD:1349485 6480464 Valproic Acid results in increased methylation of GSTT2 gene CTD PMID:29154799 vinclozolin increases expression EXP 6480464 vinclozolin results in increased expression of GSTT2 mRNA CTD PMID:22570695
Gene-Chemical Interaction Annotations
