Gstt2 (glutathione S-transferase theta 2) - Rat Genome Database

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Gene: Gstt2 (glutathione S-transferase theta 2) Rattus norvegicus
Analyze
Symbol: Gstt2
Name: glutathione S-transferase theta 2 (Ensembl:glutathione S-transferase, theta 2)
RGD ID: 69362
Description: Enables glutathione peroxidase activity and glutathione transferase activity. Involved in response to salicylic acid. Acts upstream of or within glutathione metabolic process. Predicted to be located in cytosol. Predicted to be active in cytoplasm. Biomarker of Charcot-Marie-Tooth disease. Orthologous to several human genes including GSTT2 (glutathione S-transferase theta 2 (gene/pseudogene)); PARTICIPATES IN glutathione conjugation pathway; glutathione metabolic pathway; phase I biotransformation pathway via cytochrome P450; INTERACTS WITH (+)-schisandrin B; 1-chloro-2,4-dinitrobenzene; 17beta-estradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: glutathione S-transferase 12; glutathione S-transferase theta-2; glutathione S-transferase theta-2-like; glutathione S-transferase Yrs-Yrs; glutathione S-transferase, theta 2; GST 12-12; GST class-theta-2; LOC103694878
RGD Orthologs
Human
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82012,819,053 - 12,822,724 (+)NCBIGRCr8
mRatBN7.22012,819,617 - 12,823,288 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2012,819,170 - 12,823,288 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2013,525,875 - 13,529,553 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02012,886,803 - 12,890,480 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02013,358,708 - 13,362,283 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02013,760,810 - 13,764,481 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2013,760,810 - 13,764,475 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02015,913,944 - 15,917,615 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42013,221,696 - 13,225,367 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12013,221,934 - 13,225,575 (+)NCBI
Celera2014,311,251 - 14,314,818 (+)NCBICelera
Cytogenetic Map20p12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytoplasm  (IBA,IEA)
cytosol  (ISO)
nucleus  (IEA)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Identification and characterization of GSTT3, a third murine Theta class glutathione transferase. Coggan M, etal., Biochem J. 2002 Aug 15;366(Pt 1):323-32.
2. A rat model of Charcot-Marie-Tooth disease 1A recapitulates disease variability and supplies biomarkers of axonal loss in patients. Fledrich R, etal., Brain. 2012 Jan;135(Pt 1):72-87. doi: 10.1093/brain/awr322. Epub 2011 Dec 20.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Combined genealogical, mapping, and expression approaches to identify spontaneously hypertensive rat hypertension candidate genes. Hinojos CA, etal., Hypertension 2005 Apr;45(4):698-704. Epub 2005 Feb 14.
5. Rat liver theta-class glutathione S-transferases T1-1 and T2-2: their chromatographic, electrophoretic, immunochemical, and functional properties. Hiratsuka A, etal., Anal Biochem. 1997 Oct 15;252(2):229-37.
6. A new class of rat glutathione S-transferase Yrs-Yrs inactivating reactive sulfate esters as metabolites of carcinogenic arylmethanols. Hiratsuka A, etal., J Biol Chem. 1990 Jul 15;265(20):11973-81.
7. The distribution of theta-class glutathione S-transferases in the liver and lung of mouse, rat and human. Mainwaring GW, etal., Biochem J. 1996 Aug 15;318 ( Pt 1):297-303.
8. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
9. Molecular cloning and amino acid sequencing of rat liver class theta glutathione S-transferase Yrs-Yrs inactivating reactive sulfate esters of carcinogenic arylmethanols. Ogura K, etal., Biochem Biophys Res Commun 1991 Dec 31;181(3):1294-300.
10. Isolation and characterization of the gene encoding rat class theta glutathione S-transferase subunit yrs. Ogura K, etal., Biochem Biophys Res Commun 1994 Dec 15;205(2):1250-6.
11. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
12. GOA pipeline RGD automated data pipeline
13. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
14. Glutathione S-transferase: genetics and role in toxicology. Strange RC, etal., Toxicol Lett 2000 Mar 15;112-113:357-63.
15. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
16. Nonsteroidal anti-inflammatory drugs enhance glutathione S-transferase theta levels in rat colon. Van Lieshout EM, etal., Biochim Biophys Acta. 1998 Aug 24;1381(3):305-11.
Additional References at PubMed
PMID:1848757   PMID:15489334   PMID:20439489   PMID:23533145   PMID:34758158  


Genomics

Comparative Map Data
Gstt2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82012,819,053 - 12,822,724 (+)NCBIGRCr8
mRatBN7.22012,819,617 - 12,823,288 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2012,819,170 - 12,823,288 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2013,525,875 - 13,529,553 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02012,886,803 - 12,890,480 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02013,358,708 - 13,362,283 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02013,760,810 - 13,764,481 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2013,760,810 - 13,764,475 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02015,913,944 - 15,917,615 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42013,221,696 - 13,225,367 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12013,221,934 - 13,225,575 (+)NCBI
Celera2014,311,251 - 14,314,818 (+)NCBICelera
Cytogenetic Map20p12NCBI
GSTT2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382223,980,134 - 23,983,915 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2223,980,058 - 23,983,915 (+)EnsemblGRCh38hg38GRCh38
GRCh372224,322,325 - 24,326,106 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362222,652,314 - 22,656,106 (+)NCBINCBI36Build 36hg18NCBI36
Build 342222,646,877 - 22,650,652NCBI
Celera228,122,880 - 8,126,672 (+)NCBICelera
Cytogenetic Map22q11.23ENTREZGENE
HuRef227,270,458 - 7,274,250 (+)NCBIHuRef
CHM1_12224,334,832 - 24,338,624 (+)NCBICHM1_1
T2T-CHM13v2.02224,387,435 - 24,391,322 (+)NCBIT2T-CHM13v2.0

Variants

.
Variants in Gstt2
24 total Variants

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2317057Aia27Adjuvant induced arthritis QTL 272.83joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)20289259726381954Rat
2317851Alcrsp22Alcohol response QTL 223.20.05response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)20127339237Rat
4889857Pur27Proteinuria QTL 2712.20.001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)20460660717617956Rat
4889870Pur30Proteinuria QTL 30190.005urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)20804241029322208Rat
6893685Bw111Body weight QTL 1112.70.004body mass (VT:0001259)body weight (CMO:0000012)20132578807Rat
7411668Foco32Food consumption QTL 3280.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)20136600972Rat
8694189Bw153Body weight QTL 1533.130.001body mass (VT:0001259)body weight gain (CMO:0000420)20129191651Rat
9590275Scort15Serum corticosterone level QTL 153.480.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)20129191651Rat
7411650Foco23Food consumption QTL 2320.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)20129191651Rat
7411652Foco24Food consumption QTL 240.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)201175751554435887Rat
9590109Sffal8Serum free fatty acids level QTL 85.320.01blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)20129191651Rat
9590252Scort12Serum corticosterone level QTL 1220.460.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)20136600972Rat
9589155Insul32Insulin level QTL 326.380.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)20129191651Rat
9590092Insglur9Insulin/glucose ratio QTL 918.380.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)201175751554435887Rat
1354642Despr15Despair related QTL 150.0027locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)20124159021Rat
1558640Prcs2Prostate cancer susceptibility QTL 23.3prostate integrity trait (VT:0010571)percentage of study population developing ventral prostate tumorous lesions during a period of time (CMO:0000943)20460660717617956Rat
1641893Alcrsp7Alcohol response QTL 7response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)20127339237Rat
1581577Pur15Proteinuria QTL 154.380.0002urine total protein amount (VT:0000032)urine protein excretion rate (CMO:0000759)20804241017617956Rat
1598816Memor12Memory QTL 122.4exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)20260683647606836Rat
61432Cia1Collagen induced arthritis QTL 1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)20362165614101050Rat
70154Insul2Insulin level QTL 23.75blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)20669170617489458Rat
631265Iresp1Immunoglobin response QTL18.3blood anti-double stranded DNA antibody amount (VT:0004762)serum anti-DNA antibody level (CMO:0001533)20903971913461775Rat
2305926Iddm37Insulin dependent diabetes mellitus QTL 376blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)20152784246527842Rat
1641915Colcr9Colorectal carcinoma resistance QTL 92.970.0024intestine integrity trait (VT:0010554)benign colorectal tumor number (CMO:0001795)20153065546530655Rat
1600382Edcs3Endometrial carcinoma susceptibility QTL33.50.003uterus morphology trait (VT:0001120)percentage of study population developing endometrioid carcinoma during a period of time (CMO:0001759)20125159026Rat

Markers in Region
D20Wox21  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22012,819,004 - 12,819,241 (+)MAPPERmRatBN7.2
Rnor_6.02013,760,198 - 13,760,434NCBIRnor6.0
Rnor_5.02015,913,332 - 15,913,568UniSTSRnor5.0
RGSC_v3.42013,220,415 - 13,220,651UniSTSRGSC3.4
Celera2014,310,617 - 14,310,875UniSTS
Cytogenetic Map20p12UniSTS
RH130215  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22012,823,059 - 12,823,266 (+)MAPPERmRatBN7.2
Rnor_6.02013,764,253 - 13,764,459NCBIRnor6.0
Rnor_5.02015,950,369 - 15,950,575UniSTSRnor5.0
Rnor_5.02015,917,387 - 15,917,593UniSTSRnor5.0
RGSC_v3.42013,225,139 - 13,225,345UniSTSRGSC3.4
Celera2014,314,593 - 14,314,796UniSTS
Cytogenetic Map20p12UniSTS
BF415458  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22012,820,134 - 12,820,257 (+)MAPPERmRatBN7.2
Rnor_6.02013,761,328 - 13,761,450NCBIRnor6.0
Rnor_5.02015,914,462 - 15,914,584UniSTSRnor5.0
RGSC_v3.42013,222,214 - 13,222,336UniSTSRGSC3.4
Celera2014,311,769 - 14,311,891UniSTS
RH 3.4 Map20179.22UniSTS
Cytogenetic Map20p12UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 2 32 23 1 23 5 23 29 11
Low 1 43 25 18 18 18 8 11 69 12 12 8
Below cutoff

Sequence


RefSeq Acc Id: ENSRNOT00000080203   ⟹   ENSRNOP00000074436
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2012,819,500 - 12,823,288 (+)Ensembl
Rnor_6.0 Ensembl2013,760,822 - 13,764,467 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000081140   ⟹   ENSRNOP00000071112
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2012,819,170 - 12,823,287 (+)Ensembl
Rnor_6.0 Ensembl2013,760,810 - 13,764,475 (+)Ensembl
RefSeq Acc Id: NM_012796   ⟹   NP_036928
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82012,819,053 - 12,822,724 (+)NCBI
mRatBN7.22012,819,617 - 12,823,288 (+)NCBI
Rnor_6.02013,760,810 - 13,764,481 (+)NCBI
Rnor_5.02015,913,944 - 15,917,615 (+)NCBI
RGSC_v3.42013,221,696 - 13,225,367 (+)RGD
Celera2014,311,251 - 14,314,818 (+)RGD
Sequence:
RefSeq Acc Id: NP_036928   ⟸   NM_012796
- UniProtKB: P36971 (UniProtKB/Swiss-Prot),   P30713 (UniProtKB/Swiss-Prot),   B6DYQ9 (UniProtKB/TrEMBL),   A0A8L2R9M6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000074436   ⟸   ENSRNOT00000080203
RefSeq Acc Id: ENSRNOP00000071112   ⟸   ENSRNOT00000081140
Protein Domains
GST C-terminal   GST N-terminal

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-A0A0G2JZV9-F1-model_v2 AlphaFold A0A0G2JZV9 1-68 view protein structure
AF-P30713-F1-model_v2 AlphaFold P30713 1-244 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13701532
Promoter ID:EPDNEW_R12056
Type:initiation region
Name:Gstt2_1
Description:glutathione S-transferase, theta 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.02013,760,794 - 13,760,854EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:69362 AgrOrtholog
BioCyc Gene G2FUF-4162 BioCyc
Ensembl Genes ENSRNOG00000052415 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000080203 ENTREZGENE
  ENSRNOT00000080203.2 UniProtKB/TrEMBL
  ENSRNOT00000081140.2 UniProtKB/TrEMBL
Gene3D-CATH 1.20.1050.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Glutaredoxin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:5623709 IMAGE-MGC_LOAD
InterPro Glutathione-S-Trfase_C-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Glutathione-S-Trfase_C_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Glutathione_S-Trfase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Glutathione_S-Trfase_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GST_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GST_C_Theta UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GST_N_Theta UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Thioredoxin-like_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:29487 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE MGC:72535 IMAGE-MGC_LOAD
NCBI Gene 29487 ENTREZGENE
PANTHER GLUTATHIONE S-TRANSFERASE THETA-2-RELATED UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR43917 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam GST_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GST_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Gstt2 PhenoGen
PROSITE GST_CTER UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GST_NTER UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000052415 RatGTEx
Superfamily-SCOP SSF47616 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF52833 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8L2R9M6 ENTREZGENE, UniProtKB/TrEMBL
  A0A8L2UQ98_RAT UniProtKB/TrEMBL
  A6JKG6_RAT UniProtKB/TrEMBL
  B6DYQ9 ENTREZGENE, UniProtKB/TrEMBL
  GSTT2_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  P36971 ENTREZGENE
UniProt Secondary P36971 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2022-12-20 Gstt2  glutathione S-transferase theta 2  Gstt2  glutathione S-transferase, theta 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2021-03-09 Gstt2  glutathione S-transferase, theta 2  LOC103694878  glutathione S-transferase theta-2-like  Data merged from RGD:9417129 737654 PROVISIONAL
2014-08-25 LOC103694878  glutathione S-transferase theta-2-like      Symbol and Name status set to provisional 70820 PROVISIONAL
2002-06-10 Gstt2  glutathione S-transferase, theta 2       Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression expression is decreased 2.1 fold in SHR compared with WKY rats 1357414