Hspa1a (heat shock protein family A (Hsp70) member 1A) - Rat Genome Database

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Gene: Hspa1a (heat shock protein family A (Hsp70) member 1A) Rattus norvegicus
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Symbol: Hspa1a
Name: heat shock protein family A (Hsp70) member 1A
RGD ID: 1593284
Description: Predicted to have several functions, including ATP binding activity; enzyme binding activity; and protein domain specific binding activity. Involved in several processes, including response to ethanol; response to ischemia; and response to unfolded protein. Localizes to membrane raft. Predicted to colocalize with COP9 signalosome. Human ortholog(s) of this gene implicated in several diseases, including Kawasaki disease; autoimmune disease of musculoskeletal system (multiple); cystic fibrosis; schizophrenia (multiple); and toxic shock syndrome. Orthologous to several human genes including HSPA1B (heat shock protein family A (Hsp70) member 1B); PARTICIPATES IN antigen processing and presentation pathway; endocytosis pathway; Endoplasmic Reticulum-associated degradation pathway; INTERACTS WITH (R)-lipoic acid; 1,3,5-trinitro-1,3,5-triazinane; 1-naphthyl isothiocyanate.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: heat shock 70 kDa protein 1A; Heat shock 70 kDa protein 2; heat shock 70kD protein 1A; heat shock 70kD protein 1B; heat shock 70kD protein 1B (mapped); heat shock protein 1A; Heat shock protein 70-2; heat shock protein family A member 1A; Hsp70-1; Hsp70-2; HSP70.2; Hsp72; Hspa1; Hspa1b; Hspa2
RGD Orthologs
Human
Mouse
Bonobo
Squirrel
Green Monkey
Alliance Genes
More Info more info ...
Is Marker For: Strains:   SHR-Hspa1em1Mcwi  
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
NCBI Annotation Information: Genome Annotation Status: not in current annotation release
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.0 Ensembl204,877,324 - 4,879,779 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0204,875,834 - 4,881,751 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0206,956,234 - 6,962,151 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4203,945,716 - 3,959,552 (+)NCBIRGSC3.4rn4RGSC3.4
Celera204,152,570 - 4,158,467 (-)NCBICelera
Cytogenetic Map20p12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(R)-lipoic acid  (EXP)
(S)-amphetamine  (ISO)
1,3,5-trinitro-1,3,5-triazinane  (EXP)
1-chloro-2,4-dinitrobenzene  (ISO)
1-fluoro-2,4-dinitrobenzene  (ISO)
1-naphthyl isothiocyanate  (EXP)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
1H-pyrazole  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,4-dinitrotoluene  (EXP)
2,6-dichloroindophenol  (ISO)
2-hydroxyethyl methacrylate  (ISO)
2-hydroxypropanoic acid  (ISO)
2-methylcholine  (ISO)
3,4-dihydrocoumarin  (ISO)
3-chloropropane-1,2-diol  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3-methylcholanthrene  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxynon-2-enal  (ISO)
4-phenylbutyric acid  (ISO)
5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole  (EXP)
7,12-dimethyltetraphene  (ISO)
8-Br-cAMP  (ISO)
acetylsalicylic acid  (ISO)
acrylamide  (EXP,ISO)
all-trans-retinoic acid  (ISO)
aminoglutethimide  (ISO)
ammonia  (ISO)
ammonium chloride  (EXP)
amphibole asbestos  (ISO)
aniline  (ISO)
anthra[1,9-cd]pyrazol-6(2H)-one  (EXP)
antirheumatic drug  (ISO)
apigenin  (ISO)
Aroclor 1254  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
Aurin  (ISO)
azadiradione  (ISO)
azetidinecarboxylic acid  (ISO)
benzene  (ISO)
benzene-1,2,4-triol  (ISO)
benzo[a]pyrene  (ISO)
benzo[b]fluoranthene  (ISO)
Benzo[k]fluoranthene  (ISO)
beta-naphthoflavone  (EXP)
bifenthrin  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
bortezomib  (ISO)
bromobenzene  (ISO)
C60 fullerene  (EXP)
cadmium atom  (EXP,ISO)
cadmium dichloride  (EXP,ISO)
cadmium sulfate  (ISO)
cannabidiol  (ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
carbonyl cyanide p-trifluoromethoxyphenylhydrazone  (ISO)
carbonyl sulfide  (EXP)
carboplatin  (EXP)
carrageenan  (EXP)
cefaloridine  (EXP)
celastrol  (EXP,ISO)
cerium trichloride  (ISO)
chelerythrine  (EXP)
chloroform  (EXP)
chlorohydrocarbon  (EXP)
chloromethylisothiazolinone  (ISO)
chloropicrin  (ISO)
chloroprene  (ISO)
chrysene  (ISO)
ciguatoxin CTX1B  (ISO)
cisplatin  (EXP,ISO)
clofibrate  (EXP,ISO)
cobalt atom  (EXP,ISO)
cobalt dichloride  (EXP,ISO)
cocaine  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) chloride  (ISO)
copper(II) sulfate  (ISO)
coumestrol  (ISO)
crocidolite asbestos  (ISO)
crotonaldehyde  (ISO)
CU-O LINKAGE  (ISO)
curcumin  (EXP,ISO)
cyclophosphamide  (EXP,ISO)
cyclosporin A  (ISO)
cyfluthrin  (ISO)
D-penicillamine  (ISO)
decabromodiphenyl ether  (EXP)
desferrioxamine B  (ISO)
dexamethasone  (EXP,ISO)
dextran sulfate  (ISO)
diallyl disulfide  (EXP)
diarsenic trioxide  (ISO)
diazinon  (EXP)
dibenz[a,h]anthracene  (ISO)
dibenzo[a,l]pyrene  (ISO)
dichloroacetic acid  (ISO)
diclofenac  (EXP,ISO)
dicrotophos  (ISO)
dieldrin  (EXP)
diethylstilbestrol  (ISO)
dihydroxyacetone  (ISO)
Dimethyl adipate  (EXP)
dimethyl sulfoxide  (EXP)
dioxygen  (EXP,ISO)
diquat  (ISO)
disulfiram  (ISO)
diuron  (EXP)
dorsomorphin  (ISO)
doxorubicin  (EXP,ISO)
edaravone  (EXP)
elemental selenium  (ISO)
elesclomol  (ISO)
endosulfan  (EXP)
enzyme inhibitor  (ISO)
ethanol  (ISO)
famotidine  (EXP)
fenbuconazole  (ISO)
ferric ammonium citrate  (ISO)
ferric oxide  (ISO)
flavone  (ISO)
folic acid  (ISO)
formaldehyde  (ISO)
formetanate  (ISO)
gadolinium trichloride  (EXP)
gamma-hexachlorocyclohexane  (ISO)
gedunin  (ISO)
gefitinib  (ISO)
geldanamycin  (EXP,ISO)
genistein  (EXP,ISO)
gentamycin  (EXP,ISO)
glyphosate  (ISO)
gold atom  (ISO)
gold(0)  (ISO)
GYKI 52466  (ISO)
hydrogen chloride  (EXP)
hydrogen peroxide  (ISO)
hypochlorous acid  (ISO)
ibuprofen  (ISO)
Indeno[1,2,3-cd]pyrene  (ISO)
indometacin  (ISO)
iron atom  (EXP)
iron(0)  (EXP)
ivermectin  (EXP)
kainic acid  (ISO)
kojic acid  (EXP)
L-ascorbic acid  (ISO)
lead diacetate  (ISO)
leflunomide  (ISO)
lipoic acid  (EXP)
lipopolysaccharide  (EXP,ISO)
lithium chloride  (ISO)
LY294002  (ISO)
melatonin  (ISO)
menadione  (ISO)
mercury atom  (ISO)
mercury dichloride  (EXP,ISO)
mercury(0)  (ISO)
methamphetamine  (EXP)
methomyl  (ISO)
methoxychlor  (ISO)
methyl methanesulfonate  (ISO)
methylisothiazolinone  (ISO)
methylmercury chloride  (ISO)
morphine  (EXP)
motexafin gadolinium  (ISO)
N-acetyl-L-cysteine  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (EXP,ISO)
N-methyl-N'-nitro-N-nitrosoguanidine  (EXP)
N-nitrosodiethylamine  (EXP,ISO)
N1'-[2-[[5-[(dimethylamino)methyl]-2-furanyl]methylthio]ethyl]-N1-methyl-2-nitroethene-1,1-diamine  (EXP)
naloxone  (EXP)
naphthalene  (ISO)
nickel atom  (EXP)
nickel dichloride  (ISO)
nickel sulfate  (ISO)
nitrobenzenes  (EXP)
Nonylphenol  (EXP)
ochratoxin A  (EXP,ISO)
omeprazole  (EXP)
organoselenium compound  (ISO)
orphenadrine  (EXP)
oxaliplatin  (EXP)
ozone  (EXP)
p-chloromercuribenzoic acid  (ISO)
paracetamol  (EXP,ISO)
paraquat  (ISO)
perfluorooctanoic acid  (EXP)
phenobarbital  (EXP,ISO)
PhIP  (EXP)
phorbol 13-acetate 12-myristate  (ISO)
phosgene  (ISO)
pirimicarb  (ISO)
pirinixic acid  (ISO)
piroxicam  (ISO)
polaprezinc  (EXP)
poly(I:C)  (EXP)
potassium dichromate  (ISO)
progesterone  (EXP,ISO)
propiconazole  (ISO)
Protolichesterinic acid  (ISO)
pyrene  (ISO)
quartz  (ISO)
quercetin  (ISO)
quinolin-8-ol  (ISO)
rac-lactic acid  (ISO)
radicicol  (ISO)
raloxifene  (EXP,ISO)
ranitidine  (EXP)
reactive oxygen species  (ISO)
resorcinol  (ISO)
resveratrol  (EXP,ISO)
rotenone  (EXP)
SB 431542  (ISO)
SCH772984  (EXP)
selenium atom  (ISO)
selenomethionine  (ISO)
sertraline  (ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
silver(1+) nitrate  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (EXP,ISO)
sodium dichromate  (ISO)
styrene  (ISO)
sulfasalazine  (ISO)
tamoxifen  (ISO)
tanespimycin  (ISO)
temozolomide  (ISO)
teprenone  (ISO)
tert-butyl hydroperoxide  (ISO)
tetrachloromethane  (EXP,ISO)
tetracycline  (EXP)
tetraphene  (ISO)
thimerosal  (ISO)
thioacetamide  (EXP)
thiostrepton  (ISO)
titanium dioxide  (ISO)
topotecan  (EXP)
triazines  (ISO)
tributylstannane  (EXP)
Tributyltin oxide  (EXP,ISO)
Triptolide  (ISO)
troglitazone  (ISO)
tungsten  (EXP)
Tungsten carbide  (ISO)
urethane  (ISO)
usnic acid  (ISO)
valproic acid  (ISO)
vanadium atom  (EXP)
vanadium(0)  (EXP)
vemurafenib  (ISO)
vinclozolin  (EXP)
vitamin E  (ISO)
wortmannin  (ISO)
zearalenone  (ISO)
zinc acetate  (ISO)
zinc atom  (EXP,ISO)
zinc dichloride  (ISO)
zinc molecular entity  (EXP,ISO)
zinc oxide  (ISO)
zinc pyrithione  (ISO)
zinc sulfate  (EXP,ISO)
zinc(0)  (EXP,ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
ATP metabolic process  (ISO)
cellular heat acclimation  (ISO)
cellular response to heat  (ISO)
cellular response to unfolded protein  (IBA,ISO)
chaperone cofactor-dependent protein refolding  (IBA)
chaperone-mediated protein complex assembly  (ISO)
DNA repair  (ISO)
lysosomal transport  (ISO,ISS)
mRNA catabolic process  (ISO,ISS)
negative regulation of apoptotic process  (ISO)
negative regulation of cell death  (IDA,ISO)
negative regulation of cell growth  (ISO,ISS)
negative regulation of cell population proliferation  (ISO,ISS)
negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway  (ISO)
negative regulation of extrinsic apoptotic signaling pathway in absence of ligand  (ISO)
negative regulation of inclusion body assembly  (ISO)
negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway  (ISO)
negative regulation of protein ubiquitination  (ISO)
negative regulation of transcription from RNA polymerase II promoter in response to stress  (ISO,ISS)
negative regulation of transforming growth factor beta receptor signaling pathway  (ISO)
neuron differentiation  (IEP)
positive regulation of endoribonuclease activity  (ISO)
positive regulation of erythrocyte differentiation  (ISO)
positive regulation of gene expression  (ISO)
positive regulation of interleukin-8 production  (ISO)
positive regulation of microtubule nucleation  (ISO,ISS)
positive regulation of neuron differentiation  (IMP)
positive regulation of NF-kappaB transcription factor activity  (ISO)
positive regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway  (ISO)
positive regulation of proteasomal ubiquitin-dependent protein catabolic process  (IBA,ISO)
positive regulation of RNA splicing  (ISO)
positive regulation of tumor necrosis factor-mediated signaling pathway  (ISO)
protein folding  (ISO)
protein refolding  (IBA,ISO,ISS)
protein stabilization  (ISO)
regulation of cell death  (ISO)
regulation of mitotic spindle assembly  (IBA,ISO,ISS)
regulation of protein ubiquitination  (ISO)
response to ethanol  (IEP)
response to heat  (ISO)
response to ischemia  (IEP)
response to mechanical stimulus  (IEP)
response to radiation  (IEP)
response to unfolded protein  (IMP,ISO,ISS)
telomere maintenance  (ISO)
vesicle-mediated transport  (IBA)

Cellular Component

References

References - curated
1. Arai C, etal., Histochem Cell Biol. 2010 Oct;134(4):337-43. Epub 2010 Sep 1.
2. Buraczynska M, etal., Clin Sci (Lond). 2009 Jan;116(1):81-6. doi: 10.1042/CS20070411.
3. Chien CY, etal., Audiol Neurootol. 2012;17(6):381-5. doi: 10.1159/000341815. Epub 2012 Aug 22.
4. Corvol H, etal., J Cyst Fibros. 2012 Jan;11(1):63-7. Epub 2011 Oct 10.
5. Dong Z, etal., Mol Ther. 2005 Jan;11(1):80-8.
6. Dulin E, etal., Cell Stress Chaperones. 2010 Nov;15(6):929-37. Epub 2010 May 20.
7. Dulin E, etal., Cell Stress Chaperones. 2012 Jul;17(4):507-16. doi: 10.1007/s12192-012-0328-4. Epub 2012 Feb 11.
8. Fung HC, etal., Dement Geriatr Cogn Disord. 2005;20(1):1-7. Epub 2005 Apr 12.
9. Furnrohr BG, etal., Ann Rheum Dis. 2010 Nov;69(11):1983-9. Epub 2010 May 24.
10. Garg M, etal., Eur J Cancer. 2010 Jan;46(1):207-15. doi: 10.1016/j.ejca.2009.10.020. Epub .
11. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
12. Grossin L, etal., FASEB J. 2006 Jan;20(1):65-75.
13. He M, etal., PLoS One. 2009;4(3):e4851. doi: 10.1371/journal.pone.0004851. Epub 2009 Mar 31.
14. Hua F, etal., J Neuroinflammation. 2011 May 8;8:42.
15. Jenei ZM, etal., Cell Stress Chaperones. 2013 Apr 7.
16. Jenei ZM, etal., Cell Stress Chaperones. 2013 Jul;18(4):447-54. doi: 10.1007/s12192-012-0399-2. Epub 2013 Jan 16.
17. Kawaguchi S, etal., Acta Otolaryngol. 2008 Nov;128(11):1173-7. doi: 10.1080/00016480801901675.
18. Khachatoorian R, etal., Exp Mol Pathol. 2013 Feb;94(1):243-6. doi: 10.1016/j.yexmp.2012.09.024. Epub 2012 Oct 6.
19. Kim JJ, etal., Eur Arch Psychiatry Clin Neurosci. 2008 Jun;258(4):239-44.
20. Kowalczyk M, etal., Cell Stress Chaperones. 2013 Jul 28.
21. Ledesma MD, etal., Brain Res. 2003 Oct 10;987(1):107-16.
22. Lonati C, etal., Anesthesiology. 2012 Mar;116(3):692-700. doi: 10.1097/ALN.0b013e318246ea68.
23. Maggioli E, etal., Int J Immunogenet. 2014 Feb;41(1):44-53. doi: 10.1111/iji.12077. Epub 2013 Jul 22.
24. Maheswaran S, etal., Genes Dev. 1998 Apr 15;12(8):1108-20.
25. Millenbaugh NJ, etal., Radiat Res. 2008 Mar;169(3):288-300. doi: 10.1667/RR1121.1.
26. Mosenson JA, etal., Sci Transl Med. 2013 Feb 27;5(174):174ra28. doi: 10.1126/scitranslmed.3005127.
27. Neuhofer W, etal., Pflugers Arch 2002 Oct;445(1):67-73. Epub 2002 Sep 19.
28. Novota P, etal., Transplantation. 2008 Jun 27;85(12):1809-16. doi: 10.1097/TP.0b013e31817753f7.
29. Pae CU, etal., Prog Neuropsychopharmacol Biol Psychiatry. 2007 Jun 30;31(5):1006-11. Epub 2007 Feb 27.
30. Pipeline to import KEGG annotations from KEGG into RGD
31. Rejdak K, etal., Epilepsia. 2012 May;53(5):922-7. doi: 10.1111/j.1528-1167.2012.03459.x. Epub 2012 Apr 17.
32. RGD automated data pipeline
33. RGD automated import pipeline for gene-chemical interactions
34. RGD comprehensive gene curation
35. Shao J, etal., Int J Biochem Cell Biol. 2012 Dec;44(12):2253-60. doi: 10.1016/j.biocel.2012.09.013. Epub 2012 Sep 20.
36. Wilhide ME, etal., J Mol Cell Cardiol. 2011 Jul;51(1):82-9. doi: 10.1016/j.yjmcc.2011.03.011. Epub 2011 Mar 23.
37. Yang M, etal., Cell Stress Chaperones. 2006 Autumn;11(3):233-9.
38. Zhang HN, etal., Neurol Sci. 2013 Apr;34(4):471-7. doi: 10.1007/s10072-012-1063-4. Epub 2012 Apr 18.
39. Zhang X, etal., Cardiology. 2011;119(1):57-64. doi: 10.1159/000329917. Epub 2011 Aug 17.
Additional References at PubMed
PMID:7927536   PMID:8862176   PMID:9499401   PMID:10205060   PMID:10679071   PMID:10811660   PMID:10859165   PMID:11785981   PMID:12150907   PMID:12543451   PMID:14701760   PMID:15603737  
PMID:15885686   PMID:16809764   PMID:16906134   PMID:17167422   PMID:17182002   PMID:17289661   PMID:18755693   PMID:18850735   PMID:19190083   PMID:19199708   PMID:19472539   PMID:19723345  
PMID:20458337   PMID:20625543   PMID:21231916   PMID:21423176   PMID:21909508   PMID:21975426   PMID:22495301   PMID:22516433   PMID:22658674   PMID:22681889   PMID:23349634   PMID:23533145  
PMID:23921388   PMID:24061851   PMID:24395641   PMID:24613385   PMID:24625528   PMID:24790089   PMID:25281747   PMID:25446099   PMID:25468996   PMID:26126513   PMID:27137183   PMID:27496612  
PMID:27708256   PMID:27789271  


Genomics

Comparative Map Data
Hspa1a
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.0 Ensembl204,877,324 - 4,879,779 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0204,875,834 - 4,881,751 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0206,956,234 - 6,962,151 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4203,945,716 - 3,959,552 (+)NCBIRGSC3.4rn4RGSC3.4
Celera204,152,570 - 4,158,467 (-)NCBICelera
Cytogenetic Map20p12NCBI
HSPA1A
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl631,815,543 - 31,817,946 (+)EnsemblGRCh38hg38GRCh38
GRCh38631,815,543 - 31,817,942 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37631,783,320 - 31,785,719 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36631,891,316 - 31,893,698 (+)NCBINCBI36hg18NCBI36
Build 34631,891,315 - 31,893,698NCBI
Celera633,381,540 - 33,383,968 (+)NCBI
Cytogenetic Map6p21.33NCBI
HuRef631,569,698 - 31,572,209 (+)NCBIHuRef
CHM1_1631,785,425 - 31,787,853 (+)NCBICHM1_1
Hspa1a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391735,188,335 - 35,191,132 (-)NCBIGRCm39mm39
GRCm39 Ensembl1735,188,166 - 35,191,132 (-)Ensembl
GRCm381734,969,359 - 34,972,156 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1734,969,190 - 34,972,156 (-)EnsemblGRCm38mm10GRCm38
MGSCv371735,106,304 - 35,109,101 (-)NCBIGRCm37mm9NCBIm37
MGSCv361734,577,246 - 34,580,180 (-)NCBImm8
Celera1738,065,583 - 38,068,380 (-)NCBICelera
Cytogenetic Map17B1NCBI
cM Map1718.51NCBI
HSPA1A
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1632,363,499 - 32,366,005 (+)NCBIpanpan1.1PanPan1.1panPan2
Mhudiblu_PPA_v0631,476,710 - 31,491,411 (+)NCBIMhudiblu_PPA_v0panPan3
LOC101956126
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494635,825,952 - 35,828,975 (+)NCBI
SpeTri2.0NW_0049367271,732,323 - 1,735,128 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
LOC103221745
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11740,203,647 - 40,206,028 (-)NCBI
ChlSab1.1 Ensembl1740,203,936 - 40,205,858 (-)Ensembl

Position Markers
PMC117401P1  
Rat AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map20p12UniSTS
RH128946  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.0204,877,475 - 4,877,659NCBIRnor6.0
Rnor_5.0206,957,875 - 6,958,059UniSTSRnor5.0
RGSC_v3.4203,957,727 - 3,957,911UniSTSRGSC3.4
Celera204,154,211 - 4,154,395UniSTS
RH 3.4 Map2051.62UniSTS
Cytogenetic Map20p12UniSTS
RH131596  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.0204,955,962 - 4,956,179NCBIRnor6.0
Rnor_5.0207,029,332 - 7,029,549UniSTSRnor5.0
Celera204,167,999 - 4,168,216UniSTS
RH 3.4 Map2052.42UniSTS
Cytogenetic Map20p12UniSTS
RH94530  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.0204,877,440 - 4,877,626NCBIRnor6.0
Rnor_5.0206,957,840 - 6,958,026UniSTSRnor5.0
RGSC_v3.4203,957,760 - 3,957,946UniSTSRGSC3.4
Celera204,154,176 - 4,154,362UniSTS
RH 3.4 Map2052.22UniSTS
Cytogenetic Map20p12UniSTS
PMC314357P1  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.0202,700,781 - 2,701,269NCBIRnor6.0
Rnor_6.0204,878,745 - 4,879,233NCBIRnor6.0
Rnor_5.0206,959,145 - 6,959,633UniSTSRnor5.0
Rnor_5.0204,803,650 - 4,804,138UniSTSRnor5.0
RGSC_v3.4203,956,153 - 3,956,641UniSTSRGSC3.4
Celera204,155,481 - 4,155,969UniSTS
Celera204,169,646 - 4,170,134UniSTS
Cytogenetic Map20p12UniSTS
D20Wox12  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.0204,881,491 - 4,881,694NCBIRnor6.0
Rnor_5.0206,961,891 - 6,962,094UniSTSRnor5.0
Cytogenetic Map20p12UniSTS


QTLs in Region (Rnor_6.0)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
724519Bp144Blood pressure QTL 1440.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2015192000Rat
1354642Despr15Despair related QTL 150.0027locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)20124652101Rat
1600382Edcs3Endometrial carcinoma susceptibility QTL33.50.003uterus morphology trait (VT:0001120)percentage of study population developing endometrioid carcinoma during a period of time (CMO:0001759)20125653396Rat
1641893Alcrsp7Alcohol response QTL 7response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)20126305996Rat
2317851Alcrsp22Alcohol response QTL 223.20.05response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)20126305996Rat
7387283Uae44Urinary albumin excretion QTL 440.1712urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)20127357423Rat
9590275Scort15Serum corticosterone level QTL 153.480.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)20128375393Rat
9589155Insul32Insulin level QTL 326.380.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)20128375393Rat
9590109Sffal8Serum free fatty acids level QTL 85.320.01blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)20128375393Rat
7411650Foco23Food consumption QTL 2320.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)20128375393Rat
8694189Bw153Body weight QTL 1533.130.001body mass (VT:0001259)body weight gain (CMO:0000420)20128375393Rat
6893685Bw111Body weight QTL 1112.70.004body mass (VT:0001259)body weight (CMO:0000012)20133300419Rat
9590252Scort12Serum corticosterone level QTL 1220.460.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)20137550487Rat
7411668Foco32Food consumption QTL 3280.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)20137550487Rat
2305926Iddm37Insulin dependent diabetes mellitus QTL 376blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)20201865447018654Rat
2306850Pia40Pristane induced arthritis QTL 400.0001joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)2020187706567419Rat
1641915Colcr9Colorectal carcinoma resistance QTL 92.970.0024intestine integrity trait (VT:0010554)benign colorectal tumor number (CMO:0001795)20299970747999707Rat
61472Aia1Adjuvant induced arthritis QTL 1180.001joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)2031518156896013Rat
61448Ciaa1CIA Autoantibody QTL 1300.001blood autoantibody amount (VT:0003725)calculated serum anti-rat type 2 collagen autoantibody titer (CMO:0001281)2031518156896013Rat
2317057Aia27Adjuvant induced arthritis QTL 272.83joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)20340211127968216Rat
7175096Tcs1T cell selection QTL 1T cell selectionexpression2039105555533640Rat
61474Eae1Experimental allergic encephalomyelitis QTL 13nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis severity score (CMO:0001419)2040391135875448Rat
1558640Prcs2Prostate cancer susceptibility QTL 23.3prostate integrity trait (VT:0010571)percentage of study population developing ventral prostate tumorous lesions during a period of time (CMO:0000943)20403911318872273Rat
4889857Pur27Proteinuria QTL 2712.20.001total urine protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)20403911318872273Rat
1598816Memor12Memory QTL 122.4exploratory behavior trait (VT:0010471)average horizontal distance in proximity to the target during voluntary locomotion in an experimental apparatus (CMO:0002674)20410895649108956Rat
1300152Bp195Blood pressure QTL 1953.46arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2048554689899946Rat
1331772Cdexp2CD45RC expression in CD8 T cells QTL 25.7CD8-positive T cell quantity (VT:0008077)blood CD45RChigh CD8 T cell count to CD45RClow CD8 T cell count ratio (CMO:0001990)20485546810800530Rat
61432Cia1Collagen induced arthritis QTL 1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)20485547515050565Rat


Related Rat Strains
The following Strains have been annotated to Hspa1a


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 1 3
Low 3 10 12 1 9 1 7 9 29 31 24 8 7
Below cutoff 33 42 37 10 37 1 2 43 4 16 1

Sequence


Reference Sequences
RefSeq Acc Id: NM_212504   ⟹   NP_997669
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0204,875,834 - 4,881,751 (-)NCBI
Rnor_5.0206,956,234 - 6,962,151 (-)NCBI
RGSC_v3.4203,945,716 - 3,959,552 (+)RGD
Celera204,152,570 - 4,158,467 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_997669 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein CAA54423 (Get FASTA)   NCBI Sequence Viewer  
  CAA99320 (Get FASTA)   NCBI Sequence Viewer  
  CAE83977 (Get FASTA)   NCBI Sequence Viewer  
  EDL83472 (Get FASTA)   NCBI Sequence Viewer  
  P0DMW0 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_997669   ⟸   NM_212504
- UniProtKB: P0DMW1 (UniProtKB/Swiss-Prot),   P0DMW0 (UniProtKB/Swiss-Prot)
- Sequence:

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13701372
Promoter ID:EPDNEW_R11893
Type:multiple initiation site
Name:LOC108348108_1
Description:heat shock 70 kDa protein 1A
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0204,879,825 - 4,879,885EPDNEW

Strain Variation

Strain Sequence Variants (Rnor 6.0)
ACI/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
ACI/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
ACI/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
BBDP/Wor (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
BN/SsN (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Buf/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
COP/CrCrl (MCW & UW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
University of Wisconsin (Dr. James Shull)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Charles River Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)
F344/NCrl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
F344/NRrrc (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
FHH/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHH/EurMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
FHL/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHL/EurMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
GH/OmrMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
GK/Ox (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LE/Stm (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/Crl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/NCrlBR (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LH/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LL/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LN/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
M520/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
MHS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MNS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MR/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
SBH/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBH/Ygl sequenced by MCW
SBH/Ygl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SBN/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBN/Ygl sequenced by MCW
SBN/Ygl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHR/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHRSP/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SR/JrHsd (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Harlan Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SR/JrHsd (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/Jr (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/JrHsdMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SS/JrHsdMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WAG/Rij (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
WKY/NCrl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WN/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Damaging Variants


Assembly: Rnor_6.0

Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Strain
20 4877767 4877768 T C snv WN/N (MCW), ACI/N (MCW)
20 4877851 4877852 T C snv WKY/N (MCW), WN/N (MCW)
20 4877944 4877945 C T snv ACI/N (MCW)
20 4878040 4878041 G A snv ACI/N (MCW)
20 4878127 4878128 T G snv BN/SsN (MCW), Buf/N (MCW), WKY/N (MCW), M520/N (MCW), WN/N (MCW)
20 4878133 4878134 G A snv BN/SsN (MCW)
20 4878145 4878146 C T snv BN/SsN (MCW)
20 4878235 4878236 G C snv F344/NRrrc (MCW)
20 4878320 4878321 C T snv F344/NRrrc (MCW), Buf/N (MCW), BN/SsN (MCW), ACI/N (MCW), WN/N (MCW), WKY/N (MCW), MR/N (MCW), M520/N (MCW)
20 4878406 4878407 G T snv ACI/N (MCW), M520/N (MCW)
20 4878508 4878509 T C snv M520/N (MCW), WN/N (MCW), ACI/N (MCW), MR/N (MCW)
20 4878955 4878956 C T snv WN/N (MCW)
20 4878976 4878977 C T snv F344/NRrrc (MCW)
20 4879051 4879052 C T snv WN/N (MCW)
20 4879174 4879175 G C snv ACI/N (MCW), MR/N (MCW)
20 4879483 4879484 C A snv MR/N (MCW), F344/NRrrc (MCW), WKY/N (MCW), WN/N (MCW), M520/N (MCW), BN/SsN (MCW)
20 4879579 4879580 C A snv Buf/N (MCW)


Assembly: RGSC_v3.4

Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Strain
20 3956197 3956198 C G snv HCR/1Mco (UMich), HCR/2Mco (UMich), LCR/1Mco (UMich), LCR/2Mco (UMich)
20 3956715 3956716 C A snv LCR/2Mco (UMich), HCR/1Mco (UMich), FHL/EurMcwi (MCW), FHH/EurMcwi (MCW), LCR/1Mco (UMich)


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1593284 AgrOrtholog
Ensembl Genes ENSRNOG00000045654 UniProtKB/Swiss-Prot
  ENSRNOG00000050647 Ensembl, UniProtKB/Swiss-Prot
Ensembl Protein ENSRNOP00000050605 UniProtKB/Swiss-Prot
  ENSRNOP00000067749 UniProtKB/Swiss-Prot
  ENSRNOP00000075599 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000049667 UniProtKB/Swiss-Prot
  ENSRNOT00000061950 UniProtKB/Swiss-Prot
  ENSRNOT00000081924 UniProtKB/Swiss-Prot
Gene3D-CATH 1.20.1270.10 UniProtKB/Swiss-Prot
  2.60.34.10 UniProtKB/Swiss-Prot
InterPro ATPase_NBD UniProtKB/Swiss-Prot
  Heat_shock_70_CS UniProtKB/Swiss-Prot
  HSP70_C_sf UniProtKB/Swiss-Prot
  HSP70_peptide-bd_sf UniProtKB/Swiss-Prot
  Hsp_70_fam UniProtKB/Swiss-Prot
KEGG Report rno:108348108 UniProtKB/Swiss-Prot
  rno:24472 UniProtKB/Swiss-Prot
  rno:294254 UniProtKB/Swiss-Prot
NCBI Gene 294254 ENTREZGENE
PANTHER PTHR19375 UniProtKB/Swiss-Prot
Pfam HSP70 UniProtKB/Swiss-Prot
PhenoGen Hspa1a PhenoGen
PROSITE HSP70_1 UniProtKB/Swiss-Prot
  HSP70_2 UniProtKB/Swiss-Prot
  HSP70_3 UniProtKB/Swiss-Prot
Superfamily-SCOP SSF100920 UniProtKB/Swiss-Prot
  SSF100934 UniProtKB/Swiss-Prot
  SSF53067 UniProtKB/Swiss-Prot
UniProt HS71A_RAT UniProtKB/Swiss-Prot
  HS71B_RAT UniProtKB/Swiss-Prot
  P0DMW0 ENTREZGENE
  P0DMW1 ENTREZGENE
UniProt Secondary P42853 UniProtKB/Swiss-Prot
  Q07439 UniProtKB/Swiss-Prot
  Q63256 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-10-12 Hspa1a  heat shock protein family A (Hsp70) member 1A  Hspa1a  heat shock protein family A member 1A  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2016-09-09 Hspa1a  heat shock protein family A member 1A  Hspa1a  heat shock protein 1A  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-03-12 Hspa1a  heat shock 70kD protein 1A  Hspa1  heat shock 70kD protein 1  Symbol and Name updated to reflect Human and Mouse nomenclature 1299863 APPROVED
2008-03-12 Hspa1a  heat shock protein 1A  Hspa1a  heat shock 70kD protein 1A  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2007-04-13   heat shock 70kD protein 1B  Hspa1b  heat shock 70kD protein 1B (mapped)  Name updated 737654 APPROVED
2007-04-11 Hspa1b  heat shock 70kD protein 1B (mapped)  Hspa1b_mapped  heat shock 70kD protein 1B (mapped)  Data Merged 737654 APPROVED
2006-11-20 Hspa1b  heat shock 70kD protein 1B (mapped)      Symbol and Name status set to provisional 70820 PROVISIONAL
2005-11-17 Hspa1b_mapped  heat shock 70kD protein 1B (mapped)      Symbol and Name updated 1556543 APPROVED
2002-11-06 Hspa1b  heat shock 70kD protein 1B    Heat shock protein 70-2  Name updated 625702 APPROVED
2002-06-10 Hspa1b  Heat shock protein 70-2      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_process involved in counteracting urea-mediated effects on protein function in the renal papilla 1300068