Gene: Prrc2a (proline-rich coiled-coil 2A) Rattus norvegicus
Analyze
Symbol:
Prrc2a
Name:
proline-rich coiled-coil 2A
Description:
Predicted to be involved in cell differentiation. Predicted to localize to cytosol; nucleoplasm; and plasma membrane. Human ortholog(s) of this gene implicated in type 1 diabetes mellitus. Orthologous to human PRRC2A (proline rich coiled-coil 2A); INTERACTS WITH 17beta-estradiol 3-benzoate; 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene.
Type:
protein-coding
RefSeq Status:
VALIDATED
Also known as:
Bat2; HLA-B associated transcript 2; HLA-B-associated transcript 2; large proline-rich protein BAT2; proline-rich and coiled-coil-containing protein 2A
Orthologs:
Species
Gene symbol and name
Data Source
Assertion derived from
less info ...
Orthologs 1
Homo sapiens (human):
PRRC2A (proline rich coiled-coil 2A) HGNC
Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Mus musculus (house mouse):
Prrc2a (proline-rich coiled-coil 2A) HGNC
Treefam, OrthoMCL, NCBI, HomoloGene, Inparanoid, Panther, PhylomeDB, OrthoDB, Ensembl
Chinchilla lanigera (long-tailed chinchilla):
Prrc2a (proline rich coiled-coil 2A) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):
PRRC2A (proline rich coiled-coil 2A) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Canis lupus familiaris (dog):
PRRC2A (proline rich coiled-coil 2A) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):
Prrc2a (proline rich coiled-coil 2A) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Sus scrofa (pig):
PRRC2A (proline rich coiled-coil 2A) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):
Prrc2a (proline rich coiled-coil 2A) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Other homologs 2
Homo sapiens (human):
PRRC2B (proline rich coiled-coil 2B) HGNC
OrthoMCL
Alliance orthologs 3
Homo sapiens (human):
PRRC2A (proline rich coiled-coil 2A)
Alliance
DIOPT (PANTHER|HGNC|Ensembl Compara|PhylomeDB|OrthoFinder|InParanoid|OrthoInspector|Hieranoid|TreeFam)
Mus musculus (house mouse):
Prrc2a (proline-rich coiled-coil 2A)
Alliance
DIOPT (PANTHER|Ensembl Compara|PhylomeDB|OrthoFinder|InParanoid|OrthoInspector|Hieranoid|TreeFam)
Danio rerio (zebrafish):
prrc2a (proline-rich coiled-coil 2A)
Alliance
DIOPT (Ensembl Compara|PhylomeDB|OrthoFinder|InParanoid|OrthoInspector|Hieranoid|TreeFam)
Caenorhabditis elegans (roundworm):
F52G3.1
Alliance
DIOPT (PANTHER|OrthoInspector|OrthoFinder|Ensembl Compara)
Drosophila melanogaster (fruit fly):
nocte
Alliance
DIOPT (OrthoInspector|InParanoid)
Latest Assembly:
Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl Rnor_6.0 20 5,139,881 - 5,155,371 (-) NCBI Rnor6.0 Rnor_6.0 rn6 Rnor6.0 Rnor_6.0 Ensembl 20 5,139,882 - 5,155,293 (-) Ensembl Rnor6.0 rn6 Rnor6.0 Rnor_5.0 20 7,213,139 - 7,228,817 (-) NCBI Rnor5.0 Rnor_5.0 rn5 Rnor5.0 RGSC_v3.4 20 3,724,278 - 3,737,795 (+) NCBI RGSC3.4 rn4 RGSC3.4 RGSC_v3.1 20 3,724,504 - 3,737,844 (+) NCBI Celera 20 4,351,502 - 4,365,021 (-) NCBI Celera Cytogenetic Map 20 p12 NCBI
JBrowse:
View Region in Genome Browser (JBrowse)
Model
Gene-Chemical Interaction Annotations
(+)-catechin increases expression ISO RGD:1350670 6480464 Catechin results in increased expression of PRRC2A mRNA CTD PMID:15465739 17beta-estradiol 3-benzoate increases methylation EXP 6480464 estradiol 3-benzoate results in increased methylation of PRRC2A promoter CTD PMID:27415467 2,3',4,4',5-Pentachlorobiphenyl increases expression ISO RGD:1552374 6480464 2 more ... CTD PMID:31388691 2,3,7,8-tetrachlorodibenzodioxine increases expression EXP 6480464 Tetrachlorodibenzodioxin results in increased expression of PRRC2A mRNA CTD PMID:18796159 2,4-dinitrotoluene affects expression EXP 6480464 2, 4-dinitrotoluene affects the expression of PRRC2A mRNA CTD PMID:21346803 2,6-dinitrotoluene affects expression EXP 6480464 2, 6-dinitrotoluene affects the expression of PRRC2A mRNA CTD PMID:21346803 aflatoxin B1 increases methylation ISO RGD:1350670 6480464 Aflatoxin B1 results in increased methylation of PRRC2A exon CTD PMID:30157460 arsane affects methylation ISO RGD:1350670 6480464 Arsenic affects the methylation of PRRC2A gene CTD PMID:25304211 arsenic atom affects methylation ISO RGD:1350670 6480464 Arsenic affects the methylation of PRRC2A gene CTD PMID:25304211 atrazine increases expression ISO RGD:1350670 6480464 Atrazine results in increased expression of PRRC2A mRNA CTD PMID:22378314 benzo[a]pyrene affects methylation ISO RGD:1350670 6480464 Benzo(a)pyrene affects the methylation of PRRC2A exon CTD PMID:30157460 benzo[e]pyrene increases methylation ISO RGD:1350670 6480464 benzo(e)pyrene results in increased methylation of PRRC2A exon CTD PMID:30157460 bisphenol A increases expression EXP 6480464 bisphenol A results in increased expression of PRRC2A mRNA CTD PMID:25181051 bisphenol A decreases expression EXP 6480464 bisphenol A results in decreased expression of PRRC2A mRNA CTD PMID:30816183 buta-1,3-diene decreases expression ISO RGD:1552374 6480464 1, 3-butadiene results in decreased expression of PRRC2A mRNA CTD PMID:29038090 butanal decreases expression ISO RGD:1350670 6480464 butyraldehyde results in decreased expression of PRRC2A mRNA CTD PMID:26079696 C60 fullerene increases expression EXP 6480464 fullerene C60 results in increased expression of PRRC2A mRNA CTD PMID:19167457 carbon nanotube increases expression ISO RGD:1552374 6480464 Nanotubes, Carbon analog results in increased expression of PRRC2A mRNA CTD PMID:25554681 cisplatin decreases expression ISO RGD:1350670 6480464 Cisplatin results in decreased expression of PRRC2A mRNA CTD PMID:27594783 clozapine decreases expression ISO RGD:1552374 6480464 Clozapine results in decreased expression of PRRC2A mRNA CTD PMID:18797397 coumestrol increases expression ISO RGD:1350670 6480464 Coumestrol results in increased expression of PRRC2A mRNA CTD PMID:19167446 coumestrol multiple interactions ISO RGD:1350670 6480464 [Coumestrol co-treated with 2, 3-bis(3'-hydroxybenzyl)butyrolactone] results in increased expression of PRRC2A mRNA CTD PMID:19167446 dicrotophos increases expression ISO RGD:1350670 6480464 dicrotophos results in increased expression of PRRC2A mRNA CTD PMID:28302478 Enterolactone multiple interactions ISO RGD:1350670 6480464 [Coumestrol co-treated with 2, 3-bis(3'-hydroxybenzyl)butyrolactone] results in increased expression of PRRC2A mRNA CTD PMID:19167446 enzyme inhibitor multiple interactions ISO RGD:1350670 6480464 [Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of PRRC2A protein CTD PMID:23301498 ethanol decreases expression ISO RGD:1552374 6480464 Ethanol results in decreased expression of PRRC2A mRNA CTD PMID:29018328 ethanol affects splicing ISO RGD:1552374 6480464 Ethanol affects the splicing of PRRC2A mRNA CTD PMID:30319688 ethanol increases expression ISO RGD:1552374 6480464 Ethanol results in increased expression of PRRC2A mRNA CTD PMID:30319688 flavonoids increases expression ISO RGD:1350670 6480464 Flavonoids results in increased expression of PRRC2A mRNA CTD PMID:15465739 gold atom multiple interactions ISO RGD:1552374 6480464 [Gold co-treated with Polyethylene Glycols] results in increased expression of PRRC2A mRNA CTD PMID:19695318 gold(0) multiple interactions ISO RGD:1552374 6480464 [Gold co-treated with Polyethylene Glycols] results in increased expression of PRRC2A mRNA CTD PMID:19695318 haloperidol decreases expression ISO RGD:1552374 6480464 Haloperidol results in decreased expression of PRRC2A mRNA CTD PMID:18797397 methapyrilene increases methylation ISO RGD:1350670 6480464 Methapyrilene results in increased methylation of PRRC2A exon CTD PMID:30157460 olanzapine decreases expression ISO RGD:1552374 6480464 olanzapine results in decreased expression of PRRC2A mRNA CTD PMID:18797397 paracetamol affects expression ISO RGD:1552374 6480464 Acetaminophen affects the expression of PRRC2A mRNA CTD PMID:17562736 paracetamol increases expression ISO RGD:1350670 6480464 Acetaminophen results in increased expression of PRRC2A mRNA CTD PMID:22230336 phenobarbital affects expression ISO RGD:1552374 6480464 Phenobarbital affects the expression of PRRC2A mRNA CTD PMID:19136022 pirinixic acid affects expression ISO RGD:1552374 6480464 pirinixic acid affects the expression of PRRC2A mRNA CTD PMID:19136022 progesterone decreases expression ISO RGD:1350670 6480464 Progesterone results in decreased expression of PRRC2A mRNA CTD PMID:18070364 resveratrol increases expression ISO RGD:1350670 6480464 resveratrol results in increased expression of PRRC2A mRNA CTD PMID:12002526 sodium dodecyl sulfate affects response to substance ISO RGD:1350670 6480464 PRRC2A SNP affects the susceptibility to Sodium Dodecyl Sulfate CTD PMID:27258892 titanium dioxide increases expression ISO RGD:1552374 6480464 titanium dioxide results in increased expression of PRRC2A mRNA CTD PMID:29264374 troglitazone decreases expression ISO RGD:1552374 6480464 troglitazone results in decreased expression of PRRC2A mRNA CTD PMID:28973697 tungsten decreases expression ISO RGD:1552374 6480464 Tungsten results in decreased expression of PRRC2A mRNA CTD PMID:30912803 urethane increases expression ISO RGD:1350670 6480464 Urethane results in increased expression of PRRC2A mRNA CTD PMID:28818685 valproic acid affects expression ISO RGD:1552374 6480464 Valproic Acid affects the expression of PRRC2A mRNA CTD PMID:17292431 valproic acid affects splicing EXP 6480464 Valproic Acid affects the splicing of PRRC2A mRNA CTD PMID:29427782 vinclozolin increases expression EXP 6480464 vinclozolin results in increased expression of PRRC2A mRNA CTD PMID:20566332 vinclozolin decreases expression EXP 6480464 vinclozolin results in decreased expression of PRRC2A mRNA CTD PMID:23034163
Gene Ontology Annotations
Biological Process biological_process ND 1598407 05/2009: no relevant rat data RGD cell differentiation IBA MGI:MGI:1913754 , PANTHER:PTN000361728 13792537 PMID:21873635 GO_Central Cellular Component cellular_component ND 1598407 05/2009: no relevant rat data RGD cytoplasm IEA UniProtKB-SubCell:SL-0086 1600115 GO_REF:0000044 UniProt GO_REF:0000044 cytosol IEA UniProtKB:P48634 , ensembl:ENSP000003652011600115 GO_REF:0000107 Ensembl GO_REF:0000107 cytosol IEA UniProtKB:A0A1U9X974 , ensembl:ENSP000003652011600115 GO_REF:0000107 Ensembl GO_REF:0000107 cytosol ISO RGD:1350670 1624291 RGD GO_REF:0000052 nucleoplasm IEA UniProtKB:P48634 , ensembl:ENSP000003652011600115 GO_REF:0000107 Ensembl GO_REF:0000107 nucleoplasm IEA UniProtKB:A0A1U9X974 , ensembl:ENSP000003652011600115 GO_REF:0000107 Ensembl GO_REF:0000107 nucleoplasm ISO RGD:1350670 1624291 RGD GO_REF:0000052 nucleus IEA UniProtKB-SubCell:SL-0191 1600115 GO_REF:0000044 UniProt GO_REF:0000044 plasma membrane IEA UniProtKB:P48634 , ensembl:ENSP000003652011600115 GO_REF:0000107 Ensembl GO_REF:0000107 plasma membrane IEA UniProtKB:A0A1U9X974 , ensembl:ENSP000003652011600115 GO_REF:0000107 Ensembl GO_REF:0000107 plasma membrane ISO RGD:1350670 1624291 RGD GO_REF:0000052 Molecular Function molecular_function ND 1598407 05/2009: no relevant rat data RGD protein binding ISO RGD:1350670 1624291 UniProtKB:P05412 , UniProtKB:P54253 (PMID:16713569), (PMID:20195357) RGD PMID:16713569 , PMID:20195357
724519 Bp144 Blood pressure QTL 144 0.001 arterial blood pressure trait (VT:2000000) mean arterial blood pressure (CMO:0000009) 20 1 5192000 Rat 1354642 Despr15 Despair related QTL 15 0.0027 locomotor behavior trait (VT:0001392) amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958) 20 1 24652101 Rat 1600382 Edcs3 Endometrial carcinoma susceptibility QTL3 3.5 0.003 uterus morphology trait (VT:0001120) percentage of study population developing endometrioid carcinoma during a period of time (CMO:0001759) 20 1 25653396 Rat 1641893 Alcrsp7 Alcohol response QTL 7 response to alcohol trait (VT:0010489) duration of loss of righting reflex (CMO:0002289) 20 1 26305996 Rat 2317851 Alcrsp22 Alcohol response QTL 22 3.2 0.05 response to alcohol trait (VT:0010489) duration of loss of righting reflex (CMO:0002289) 20 1 26305996 Rat 7387283 Uae44 Urinary albumin excretion QTL 44 0.1712 urine albumin amount (VT:0002871) urine albumin excretion rate (CMO:0000757) 20 1 27357423 Rat 9590275 Scort15 Serum corticosterone level QTL 15 3.48 0.001 blood corticosterone amount (VT:0005345) plasma corticosterone level (CMO:0001173) 20 1 28375393 Rat 9589155 Insul32 Insulin level QTL 32 6.38 0.001 blood insulin amount (VT:0001560) plasma insulin level (CMO:0000342) 20 1 28375393 Rat 9590109 Sffal8 Serum free fatty acids level QTL 8 5.32 0.01 blood free fatty acid amount (VT:0001553) plasma free fatty acids level (CMO:0000546) 20 1 28375393 Rat 7411650 Foco23 Food consumption QTL 23 20.7 0.001 eating behavior trait (VT:0001431) feed conversion ratio (CMO:0001312) 20 1 28375393 Rat 8694189 Bw153 Body weight QTL 153 3.13 0.001 body mass (VT:0001259) body weight gain (CMO:0000420) 20 1 28375393 Rat 6893685 Bw111 Body weight QTL 111 2.7 0.004 body mass (VT:0001259) body weight (CMO:0000012) 20 1 33300419 Rat 9590252 Scort12 Serum corticosterone level QTL 12 20.46 0.001 blood corticosterone amount (VT:0005345) plasma corticosterone level (CMO:0001173) 20 1 37550487 Rat 7411668 Foco32 Food consumption QTL 32 8 0.001 eating behavior trait (VT:0001431) feed conversion ratio (CMO:0001312) 20 1 37550487 Rat 2305926 Iddm37 Insulin dependent diabetes mellitus QTL 37 6 blood glucose amount (VT:0000188) plasma glucose level (CMO:0000042) 20 2018654 47018654 Rat 2306850 Pia40 Pristane induced arthritis QTL 40 0.0001 joint integrity trait (VT:0010548) joint inflammation composite score (CMO:0000919) 20 2018770 6567419 Rat 1641915 Colcr9 Colorectal carcinoma resistance QTL 9 2.97 0.0024 intestine integrity trait (VT:0010554) benign colorectal tumor number (CMO:0001795) 20 2999707 47999707 Rat 61472 Aia1 Adjuvant induced arthritis QTL 1 18 0.001 joint integrity trait (VT:0010548) joint inflammation composite score (CMO:0000919) 20 3151815 6896013 Rat 61448 Ciaa1 CIA Autoantibody QTL 1 30 0.001 blood autoantibody amount (VT:0003725) calculated serum anti-rat type 2 collagen autoantibody titer (CMO:0001281) 20 3151815 6896013 Rat 2317057 Aia27 Adjuvant induced arthritis QTL 27 2.83 joint integrity trait (VT:0010548) right rear ankle joint diameter (CMO:0002150) 20 3402111 27968216 Rat 7175096 Tcs1 T cell selection QTL 1 T cell selection expression 20 3910555 5533640 Rat 61474 Eae1 Experimental allergic encephalomyelitis QTL 1 3 nervous system integrity trait (VT:0010566) experimental autoimmune encephalomyelitis severity score (CMO:0001419) 20 4039113 5875448 Rat 1558640 Prcs2 Prostate cancer susceptibility QTL 2 3.3 prostate integrity trait (VT:0010571) percentage of study population developing ventral prostate tumorous lesions during a period of time (CMO:0000943) 20 4039113 18872273 Rat 4889857 Pur27 Proteinuria QTL 27 12.2 0.001 total urine protein amount (VT:0000032) urine total protein excretion rate (CMO:0000756) 20 4039113 18872273 Rat 1598816 Memor12 Memory QTL 12 2.4 exploratory behavior trait (VT:0010471) average horizontal distance in proximity to the target during voluntary locomotion in an experimental apparatus (CMO:0002674) 20 4108956 49108956 Rat 1300152 Bp195 Blood pressure QTL 195 3.46 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) 20 4855468 9899946 Rat 1331772 Cdexp2 CD45RC expression in CD8 T cells QTL 2 5.7 CD8-positive T cell quantity (VT:0008077) blood CD45RChigh CD8 T cell count to CD45RClow CD8 T cell count ratio (CMO:0001990) 20 4855468 10800530 Rat 61432 Cia1 Collagen induced arthritis QTL 1 joint integrity trait (VT:0010548) joint inflammation composite score (CMO:0000919) 20 4855475 15050565 Rat
Predicted Target Of
Count of predictions: 103 Count of miRNA genes: 90 Interacting mature miRNAs: 95 Transcripts: ENSRNOT00000001133 Prediction methods: Microtar, Miranda, Rnahybrid, Targetscan Result types: miRGate_prediction
Gene-Chemical Interaction Annotations
