Slc16a9 (solute carrier family 16, member 9) - Rat Genome Database

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Gene: Slc16a9 (solute carrier family 16, member 9) Rattus norvegicus
Analyze
Symbol: Slc16a9
Name: solute carrier family 16, member 9
RGD ID: 1596295
Description: Enables creatine transmembrane transporter activity. Involved in creatine transmembrane transport. Located in plasma membrane. Orthologous to human SLC16A9 (solute carrier family 16 member 9); INTERACTS WITH 3-chloropropane-1,2-diol; bisphenol A; methoxychlor.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: AABR07044759.1; LOC687808; MCT 9; monocarboxylate transporter 9; similar to solute carrier family 16 (monocarboxylic acid transporters), member 9
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82018,334,946 - 18,376,195 (-)NCBIGRCr8
mRatBN7.22018,335,862 - 18,377,125 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2018,335,862 - 18,377,022 (-)EnsemblmRatBN7.2 Ensembl
Rnor_6.02019,634,280 - 19,675,358 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2019,636,159 - 19,637,958 (-)NCBIRnor6.0rn6Rnor6.0
Rnor_5.02021,771,563 - 21,811,471 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera2019,725,495 - 19,767,853 (-)NCBICelera
Cytogenetic Map20p11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
plasma membrane  (IBA,IDA,ISO)

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Contribution of monocarboxylate transporter 12 to blood supply of creatine on the sinusoidal membrane of the hepatocytes. Jomura R, etal., Am J Physiol Gastrointest Liver Physiol. 2021 Aug 1;321(2):G113-G122. doi: 10.1152/ajpgi.00143.2021. Epub 2021 Jun 2.
3. GOA pipeline RGD automated data pipeline
4. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:19503597  


Genomics

Comparative Map Data
Slc16a9
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82018,334,946 - 18,376,195 (-)NCBIGRCr8
mRatBN7.22018,335,862 - 18,377,125 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2018,335,862 - 18,377,022 (-)EnsemblmRatBN7.2 Ensembl
Rnor_6.02019,634,280 - 19,675,358 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2019,636,159 - 19,637,958 (-)NCBIRnor6.0rn6Rnor6.0
Rnor_5.02021,771,563 - 21,811,471 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera2019,725,495 - 19,767,853 (-)NCBICelera
Cytogenetic Map20p11NCBI
SLC16A9
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381059,650,764 - 59,710,079 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1059,650,764 - 59,736,002 (-)EnsemblGRCh38hg38GRCh38
GRCh371061,410,522 - 61,469,837 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361061,080,529 - 61,165,766 (-)NCBINCBI36Build 36hg18NCBI36
Build 341061,080,528 - 61,165,766NCBI
Celera1054,676,299 - 54,735,417 (-)NCBICelera
Cytogenetic Map10q21.2NCBI
HuRef1055,397,809 - 55,456,685 (-)NCBIHuRef
CHM1_11061,692,271 - 61,751,834 (-)NCBICHM1_1
T2T-CHM13v2.01060,504,785 - 60,564,169 (-)NCBIT2T-CHM13v2.0
Slc16a9
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391070,081,106 - 70,121,781 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1070,080,930 - 70,121,798 (+)EnsemblGRCm39 Ensembl
GRCm381070,245,276 - 70,285,951 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1070,245,100 - 70,285,968 (+)EnsemblGRCm38mm10GRCm38
MGSCv371069,708,024 - 69,748,699 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361069,640,633 - 69,681,308 (+)NCBIMGSCv36mm8
Celera1071,336,409 - 71,374,457 (+)NCBICelera
Cytogenetic Map10B5.3NCBI
cM Map1036.68NCBI
Slc16a9
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542513,249,903 - 13,300,705 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495542513,249,903 - 13,300,705 (-)NCBIChiLan1.0ChiLan1.0
SLC16A9
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2871,867,102 - 71,921,936 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11071,872,423 - 71,927,094 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01056,189,435 - 56,267,628 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11058,404,944 - 58,482,664 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1058,404,944 - 58,458,990 (-)Ensemblpanpan1.1panPan2
SLC16A9
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1411,865,642 - 11,924,345 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl411,866,491 - 11,913,412 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha412,063,124 - 12,121,851 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0412,128,158 - 12,186,934 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl412,128,158 - 12,179,835 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1412,104,839 - 12,163,501 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0412,223,627 - 12,282,443 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0412,534,710 - 12,593,420 (-)NCBIUU_Cfam_GSD_1.0
Slc16a9
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440721369,364,989 - 69,421,446 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366143,473,967 - 3,505,190 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366143,451,725 - 3,507,687 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SLC16A9
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1463,026,663 - 63,108,997 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11463,026,661 - 63,109,137 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21468,002,954 - 68,083,672 (-)NCBISscrofa10.2Sscrofa10.2susScr3
SLC16A9
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1971,576,800 - 71,637,147 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl971,576,759 - 71,637,380 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604832,461,861 - 32,522,221 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Slc16a9
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247913,870,193 - 3,936,260 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247913,870,289 - 3,935,268 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Slc16a9
287 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:10
Count of miRNA genes:10
Interacting mature miRNAs:10
Transcripts:ENSRNOT00000074657
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4889610Pancm3Pancreatic morphology QTL 33.750.001pancreas mass (VT:0010144)pancreas wet weight (CMO:0000626)201761783247606836Rat
1641915Colcr9Colorectal carcinoma resistance QTL 92.970.0024intestine integrity trait (VT:0010554)benign colorectal tumor number (CMO:0001795)20153065546530655Rat
2317057Aia27Adjuvant induced arthritis QTL 272.83joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)20289259726381954Rat
7387283Uae44Urinary albumin excretion QTL 440.1712urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)20126123605Rat
4889870Pur30Proteinuria QTL 30190.005urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)20804241029322208Rat
7411668Foco32Food consumption QTL 3280.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)20136600972Rat
2305926Iddm37Insulin dependent diabetes mellitus QTL 376blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)20152784246527842Rat
1354642Despr15Despair related QTL 150.0027locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)20124159021Rat
1600382Edcs3Endometrial carcinoma susceptibility QTL33.50.003uterus morphology trait (VT:0001120)percentage of study population developing endometrioid carcinoma during a period of time (CMO:0001759)20125159026Rat
8694189Bw153Body weight QTL 1533.130.001body mass (VT:0001259)body weight gain (CMO:0000420)20129191651Rat
9590109Sffal8Serum free fatty acids level QTL 85.320.01blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)20129191651Rat
9590275Scort15Serum corticosterone level QTL 153.480.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)20129191651Rat
9589155Insul32Insulin level QTL 326.380.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)20129191651Rat
7411650Foco23Food consumption QTL 2320.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)20129191651Rat
7411652Foco24Food consumption QTL 240.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)201175751554435887Rat
2317851Alcrsp22Alcohol response QTL 223.20.05response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)20127339237Rat
1598816Memor12Memory QTL 122.4exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)20260683647606836Rat
2317880Alcrsp25Alcohol response QTL 252.3response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)201769755054435887Rat
1641893Alcrsp7Alcohol response QTL 7response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)20127339237Rat
6893685Bw111Body weight QTL 1112.70.004body mass (VT:0001259)body weight (CMO:0000012)20132578807Rat
9590252Scort12Serum corticosterone level QTL 1220.460.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)20136600972Rat
9590092Insglur9Insulin/glucose ratio QTL 918.380.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)201175751554435887Rat

Markers in Region
RH133176  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr82018,337,076 - 18,337,987 (+)Marker Load Pipeline
mRatBN7.22018,337,992 - 18,338,903 (+)MAPPERmRatBN7.2
Rnor_6.02019,636,204 - 19,637,114NCBIRnor6.0
Rnor_5.02021,772,717 - 21,773,627UniSTSRnor5.0
Celera2019,727,419 - 19,728,329UniSTS
RH 3.4 Map20227.78UniSTS


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSRNOT00000074657   ⟹   ENSRNOP00000067303
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2018,335,862 - 18,377,022 (-)Ensembl
RefSeq Acc Id: NM_001421109   ⟹   NP_001408038
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82018,334,946 - 18,376,195 (-)NCBI
mRatBN7.22018,335,862 - 18,377,125 (-)NCBI
RefSeq Acc Id: XM_039099158   ⟹   XP_038955086
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82018,334,957 - 18,339,161 (-)NCBI
mRatBN7.22018,336,142 - 18,340,177 (-)NCBI
RefSeq Acc Id: XM_039099159   ⟹   XP_038955087
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82018,334,957 - 18,342,866 (-)NCBI
mRatBN7.22018,336,142 - 18,344,321 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001408038 (Get FASTA)   NCBI Sequence Viewer  
  XP_038955086 (Get FASTA)   NCBI Sequence Viewer  
  XP_038955087 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000067303.3
  ENSRNOP00055030818
  ENSRNOP00060032449
  ENSRNOP00065034083
GenBank Protein M0RCI4 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: XP_038955087   ⟸   XM_039099159
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038955086   ⟸   XM_039099158
- Peptide Label: isoform X1
Ensembl Acc Id: ENSRNOP00000067303   ⟸   ENSRNOT00000074657
RefSeq Acc Id: NP_001408038   ⟸   NM_001421109
- UniProtKB: M0RCI4 (UniProtKB/Swiss-Prot),   A6JKR0 (UniProtKB/TrEMBL)
Protein Domains
Major facilitator superfamily (MFS) profile

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-M0RCI4-F1-model_v2 AlphaFold M0RCI4 1-364 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1596295 AgrOrtholog
BioCyc Gene G2FUF-3984 BioCyc
Ensembl Genes ENSRNOG00000049063 Ensembl, UniProtKB/Swiss-Prot
  ENSRNOG00055022005 UniProtKB/Swiss-Prot
  ENSRNOG00060022627 UniProtKB/Swiss-Prot
  ENSRNOG00065024322 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000074657.3 UniProtKB/Swiss-Prot
  ENSRNOT00055037776 UniProtKB/Swiss-Prot
  ENSRNOT00060039243 UniProtKB/Swiss-Prot
  ENSRNOT00065041700 UniProtKB/Swiss-Prot
Gene3D-CATH MFS general substrate transporter like domains UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro MCT9 UniProtKB/Swiss-Prot
  MFS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MFS_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MFS_trans_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Proton-linked_MCT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 687808 ENTREZGENE
PANTHER MONOCARBOXYLATE TRANSPORTER UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MONOCARBOXYLATE TRANSPORTER 9 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam MFS_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Slc16a9 PhenoGen
PROSITE MFS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000049063 RatGTEx
  ENSRNOG00055022005 RatGTEx
  ENSRNOG00060022627 RatGTEx
  ENSRNOG00065024322 RatGTEx
Superfamily-SCOP MFS general substrate transporter UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A6JKR0 ENTREZGENE, UniProtKB/TrEMBL
  M0RCI4 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2022-06-02 Slc16a9  solute carrier family 16, member 9  AABR07044759.1    Data merged from RGD:15005661 737654 PROVISIONAL
2019-11-08 AABR07044759.1        Symbol and Name status set to provisional 45752 PROVISIONAL
2014-10-03 Slc16a9  solute carrier family 16, member 9  LOC687808  similar to solute carrier family 16 (monocarboxylic acid transporters), member 9  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-11-20 LOC687808  similar to solute carrier family 16 (monocarboxylic acid transporters), member 9      Symbol and Name status set to provisional 70820 PROVISIONAL