Gucd1 (guanylyl cyclase domain containing 1) - Rat Genome Database

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Gene: Gucd1 (guanylyl cyclase domain containing 1) Rattus norvegicus
Analyze
Symbol: Gucd1
Name: guanylyl cyclase domain containing 1
RGD ID: 1597571
Description: Involved in liver regeneration and response to cAMP. Orthologous to human GUCD1 (guanylyl cyclase domain containing 1); INTERACTS WITH (+)-schisandrin B; acetamide; bisphenol A.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: guanylyl cyclase domain-containing protein 1; hypothetical protein LOC687713; LOC687713; MGC189376; similar to Protein C22orf13 homolog; uncharacterized protein LOC687713
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82013,145,055 - 13,155,765 (+)NCBIGRCr8
mRatBN7.22013,145,617 - 13,156,330 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2013,146,076 - 13,156,328 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2013,852,880 - 13,861,046 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02013,213,826 - 13,221,992 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02013,686,331 - 13,694,497 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02014,096,030 - 14,102,901 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2014,095,914 - 14,103,993 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02016,281,311 - 16,288,419 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera2014,631,886 - 14,639,912 (+)NCBICelera
Cytogenetic Map20p12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. NEDD4 controls the expression of GUCD1, a protein upregulated in proliferating liver cells. Bellet MM, etal., Cell Cycle. 2014;13(12):1902-11. doi: 10.4161/cc.28760. Epub 2014 Apr 17.
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12477932   PMID:15632090  


Genomics

Comparative Map Data
Gucd1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82013,145,055 - 13,155,765 (+)NCBIGRCr8
mRatBN7.22013,145,617 - 13,156,330 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2013,146,076 - 13,156,328 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2013,852,880 - 13,861,046 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02013,213,826 - 13,221,992 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02013,686,331 - 13,694,497 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02014,096,030 - 14,102,901 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2014,095,914 - 14,103,993 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02016,281,311 - 16,288,419 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera2014,631,886 - 14,639,912 (+)NCBICelera
Cytogenetic Map20p12NCBI
GUCD1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382224,540,438 - 24,555,894 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2224,540,423 - 24,555,935 (-)EnsemblGRCh38hg38GRCh38
GRCh372224,936,406 - 24,951,862 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362223,266,406 - 23,281,275 (-)NCBINCBI36Build 36hg18NCBI36
Build 342223,260,963 - 23,275,829NCBI
Celera228,736,128 - 8,750,998 (-)NCBICelera
Cytogenetic Map22q11.23NCBI
HuRef227,886,023 - 7,900,969 (-)NCBIHuRef
CHM1_12224,895,155 - 24,910,024 (-)NCBICHM1_1
T2T-CHM13v2.02225,002,044 - 25,017,501 (-)NCBIT2T-CHM13v2.0
Gucd1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391075,342,648 - 75,353,806 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1075,186,945 - 75,353,806 (-)EnsemblGRCm39 Ensembl
GRCm381075,506,814 - 75,517,972 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1075,351,111 - 75,517,972 (-)EnsemblGRCm38mm10GRCm38
MGSCv371074,969,559 - 74,980,067 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361074,950,002 - 74,961,134 (-)NCBIMGSCv36mm8
Celera1076,551,572 - 76,562,082 (-)NCBICelera
Cytogenetic Map10C1NCBI
cM Map1038.53NCBI
Gucd1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554558,007,112 - 8,021,666 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554558,010,187 - 8,021,666 (-)NCBIChiLan1.0ChiLan1.0
GUCD1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22334,329,182 - 34,344,687 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12237,059,647 - 37,075,325 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0225,346,554 - 5,362,171 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12222,212,000 - 22,227,613 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2222,212,000 - 22,227,503 (-)Ensemblpanpan1.1panPan2
GUCD1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12628,234,245 - 28,247,204 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2627,309,379 - 27,322,964 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02629,638,546 - 29,652,133 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2629,638,546 - 29,651,525 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12627,722,489 - 27,736,077 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02627,339,490 - 27,353,070 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02628,329,151 - 28,342,734 (-)NCBIUU_Cfam_GSD_1.0
Gucd1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118142,025,378 - 142,076,664 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936619715,875 - 728,916 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936619709,535 - 728,849 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GUCD1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1449,572,822 - 49,585,057 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11449,572,031 - 49,585,051 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21453,014,674 - 53,027,598 (-)NCBISscrofa10.2Sscrofa10.2susScr3
GUCD1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1197,578,125 - 7,589,196 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl197,583,642 - 7,591,253 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660854,779,694 - 4,793,470 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Gucd1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247479,960,847 - 9,973,607 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247479,958,474 - 9,973,847 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Gucd1
24 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:404
Count of miRNA genes:218
Interacting mature miRNAs:257
Transcripts:ENSRNOT00000072696
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1354642Despr15Despair related QTL 150.0027locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)20124159021Rat
1600382Edcs3Endometrial carcinoma susceptibility QTL33.50.003uterus morphology trait (VT:0001120)percentage of study population developing endometrioid carcinoma during a period of time (CMO:0001759)20125159026Rat
2317851Alcrsp22Alcohol response QTL 223.20.05response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)20127339237Rat
1641893Alcrsp7Alcohol response QTL 7response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)20127339237Rat
8694189Bw153Body weight QTL 1533.130.001body mass (VT:0001259)body weight gain (CMO:0000420)20129191651Rat
9590275Scort15Serum corticosterone level QTL 153.480.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)20129191651Rat
7411650Foco23Food consumption QTL 2320.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)20129191651Rat
9590109Sffal8Serum free fatty acids level QTL 85.320.01blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)20129191651Rat
9589155Insul32Insulin level QTL 326.380.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)20129191651Rat
6893685Bw111Body weight QTL 1112.70.004body mass (VT:0001259)body weight (CMO:0000012)20132578807Rat
7411668Foco32Food consumption QTL 3280.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)20136600972Rat
9590252Scort12Serum corticosterone level QTL 1220.460.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)20136600972Rat
2305926Iddm37Insulin dependent diabetes mellitus QTL 376blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)20152784246527842Rat
1641915Colcr9Colorectal carcinoma resistance QTL 92.970.0024intestine integrity trait (VT:0010554)benign colorectal tumor number (CMO:0001795)20153065546530655Rat
1598816Memor12Memory QTL 122.4exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)20260683647606836Rat
2317057Aia27Adjuvant induced arthritis QTL 272.83joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)20289259726381954Rat
61432Cia1Collagen induced arthritis QTL 1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)20362165614101050Rat
4889857Pur27Proteinuria QTL 2712.20.001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)20460660717617956Rat
1558640Prcs2Prostate cancer susceptibility QTL 23.3prostate integrity trait (VT:0010571)percentage of study population developing ventral prostate tumorous lesions during a period of time (CMO:0000943)20460660717617956Rat
70154Insul2Insulin level QTL 23.75blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)20669170617489458Rat
1581577Pur15Proteinuria QTL 154.380.0002urine total protein amount (VT:0000032)urine protein excretion rate (CMO:0000759)20804241017617956Rat
4889870Pur30Proteinuria QTL 30190.005urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)20804241029322208Rat
631265Iresp1Immunoglobin response QTL18.3blood anti-double stranded DNA antibody amount (VT:0004762)serum anti-DNA antibody level (CMO:0001533)20903971913461775Rat
7411652Foco24Food consumption QTL 240.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)201175751554435887Rat
9590092Insglur9Insulin/glucose ratio QTL 918.380.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)201175751554435887Rat

Markers in Region
RH129932  
Rat AssemblyChrPosition (strand)SourceJBrowse
Celera2014,641,612 - 14,641,810UniSTS
RH 3.4 Map20153.74UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 43 56 41 19 41 8 11 63 35 35 11 8
Low 1 11 6
Below cutoff

Sequence


RefSeq Acc Id: ENSRNOT00000072696   ⟹   ENSRNOP00000064961
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2013,150,821 - 13,156,328 (+)Ensembl
Rnor_6.0 Ensembl2014,101,659 - 14,103,993 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000093404   ⟹   ENSRNOP00000076214
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl2014,095,914 - 14,096,072 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000111031   ⟹   ENSRNOP00000081335
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2013,149,466 - 13,156,328 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000115916   ⟹   ENSRNOP00000097309
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2013,146,076 - 13,156,328 (+)Ensembl
RefSeq Acc Id: NM_001134997   ⟹   NP_001128469
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82013,145,517 - 13,155,765 (+)NCBI
mRatBN7.22013,146,079 - 13,156,328 (+)NCBI
Rnor_6.02014,096,030 - 14,102,901 (+)NCBI
Rnor_5.02016,281,311 - 16,288,419 (+)NCBI
Celera2014,631,886 - 14,639,912 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001412126   ⟹   NP_001399055
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82013,145,055 - 13,155,765 (+)NCBI
mRatBN7.22013,145,617 - 13,156,328 (+)NCBI
RefSeq Acc Id: XM_039099072   ⟹   XP_038955000
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82013,145,501 - 13,155,765 (+)NCBI
mRatBN7.22013,146,076 - 13,156,330 (+)NCBI
RefSeq Acc Id: XM_039099073   ⟹   XP_038955001
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82013,145,063 - 13,155,765 (+)NCBI
mRatBN7.22013,145,627 - 13,156,328 (+)NCBI
RefSeq Acc Id: NP_001128469   ⟸   NM_001134997
- Peptide Label: isoform 1
- UniProtKB: B5DFC7 (UniProtKB/TrEMBL),   R4UB37 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000064961   ⟸   ENSRNOT00000072696
RefSeq Acc Id: ENSRNOP00000076214   ⟸   ENSRNOT00000093404
RefSeq Acc Id: XP_038955001   ⟸   XM_039099073
- Peptide Label: isoform X2
- UniProtKB: A6JKK5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038955000   ⟸   XM_039099072
- Peptide Label: isoform X1
- UniProtKB: A0A8I6ASP6 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSRNOP00000081335   ⟸   ENSRNOT00000111031
RefSeq Acc Id: ENSRNOP00000097309   ⟸   ENSRNOT00000115916
RefSeq Acc Id: NP_001399055   ⟸   NM_001412126
- Peptide Label: isoform 2
- UniProtKB: A6JKK5 (UniProtKB/TrEMBL)

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-M0R6B5-F1-model_v2 AlphaFold M0R6B5 1-141 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13701546
Promoter ID:EPDNEW_R12066
Type:initiation region
Name:Gucd1_1
Description:guanylyl cyclase domain containing 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.02014,095,884 - 14,095,944EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1597571 AgrOrtholog
BioCyc Gene G2FUF-4140 BioCyc
Ensembl Genes ENSRNOG00000049952 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000072696 ENTREZGENE
  ENSRNOT00000072696.4 UniProtKB/TrEMBL
  ENSRNOT00000111031.1 UniProtKB/TrEMBL
  ENSRNOT00000115916.1 UniProtKB/TrEMBL
Gene3D-CATH Cysteine proteinases UniProtKB/TrEMBL
InterPro Guanylyl_cyclase UniProtKB/TrEMBL
KEGG Report rno:687713 UniProtKB/TrEMBL
NCBI Gene 687713 ENTREZGENE
PANTHER PROTEIN GUCD1 UniProtKB/TrEMBL
  PTHR31400 UniProtKB/TrEMBL
Pfam Guanylate_cyc_2 UniProtKB/TrEMBL
PhenoGen Gucd1 PhenoGen
RatGTEx ENSRNOG00000049952 RatGTEx
UniProt A0A8I5ZSK9_RAT UniProtKB/TrEMBL
  A0A8I6ASP6 ENTREZGENE, UniProtKB/TrEMBL
  A6JKK5 ENTREZGENE, UniProtKB/TrEMBL
  B5DFC7 ENTREZGENE, UniProtKB/TrEMBL
  M0R6B5_RAT UniProtKB/TrEMBL
  R4UB37 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2013-08-16 Gucd1  guanylyl cyclase domain containing 1  LOC687713  similar to Protein C22orf13 homolog  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED