Specc1l (sperm antigen with calponin homology and coiled-coil domains 1-like) - Rat Genome Database

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Gene: Specc1l (sperm antigen with calponin homology and coiled-coil domains 1-like) Rattus norvegicus
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Symbol: Specc1l
Name: sperm antigen with calponin homology and coiled-coil domains 1-like
RGD ID: 1309570
Description: Predicted to enable beta-catenin binding activity. Predicted to be involved in actin cytoskeleton organization. Predicted to act upstream of or within several processes, including anterior neural tube closure; negative regulation of protein depolymerization; and positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction. Predicted to be located in cell-cell junction; cytoplasm; and cytoskeleton. Predicted to be part of filamentous actin. Predicted to be active in microtubule organizing center. Human ortholog(s) of this gene implicated in Teebi hypertelorism syndrome 1 and oblique facial clefting 1. Orthologous to human SPECC1L (sperm antigen with calponin homology and coiled-coil domains 1 like); INTERACTS WITH bisphenol A; cadmium dichloride; chlorpyrifos.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 28S ribosomal protein S7, mitochondrial-like; cytospin A; cytospin-A; Cytsa; LOC102546441; LOC361828; RGD1309570; similar to mKIAA0376 protein; SPECC1-like
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82013,337,399 - 13,443,080 (-)NCBIGRCr8
mRatBN7.22013,337,983 - 13,443,665 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2013,339,692 - 13,443,665 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2014,046,241 - 14,150,210 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02013,407,064 - 13,511,031 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02013,879,707 - 13,983,644 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02014,287,470 - 14,393,879 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2014,287,457 - 14,393,793 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02016,470,744 - 16,577,173 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42013,840,439 - 13,945,178 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12013,838,941 - 13,945,405 (-)NCBI
Celera2014,825,150 - 14,929,010 (-)NCBICelera
Cytogenetic Map20p12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


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Object Symbol
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Original Reference(s)
Specc1lRatCraniosynostosis Syndrome, Autosomal Recessive  ISORGD:16036828554872ClinVar Annotator: match by term: Craniosynostosis syndromeClinVarPMID:25741868|PMID:28492532|PMID:31837199
Specc1lRatDiGeorge syndrome  ISORGD:16036828554872ClinVar Annotator: match by term: Autosomal dominant Opitz G/BBB syndromeClinVarPMID:25741868|PMID:28492532
Specc1lRatepilepsy  ISORGD:16036828554872ClinVar Annotator: match by term: EpilepsyClinVar 
Specc1lRatgenetic disease  ISORGD:16036828554872ClinVar Annotator: match by term: Inborn genetic diseasesClinVarPMID:25741868|PMID:28492532
Specc1lRatintellectual disability  ISORGD:16036828554872ClinVar Annotator: match by term: Intellectual disabilityClinVarPMID:25741868
Specc1lRatoblique facial clefting 1  ISORGD:16036828554872ClinVar Annotator: match by term: Oblique facial clefts | ClinVar Annotator: match by term: Oculomaxillofacial more ...ClinVarPMID:21703590|PMID:25741868|PMID:28492532
Specc1lRatprostate cancer  ISORGD:16036828554872ClinVar Annotator: match by term: Malignant tumor of prostateClinVarPMID:23265383
Specc1lRatschizophrenia  ISORGD:16036828554872ClinVar Annotator: match by term: SchizophreniaClinVarPMID:21681106|PMID:30208311
Specc1lRatTeebi hypertelorism syndrome  ISORGD:16036828554872ClinVar Annotator: match by term: Teebi hypertelorism syndromeClinVarPMID:17506099|PMID:25412741|PMID:25741868|PMID:25741869|PMID:26111080|PMID:28492532|PMID:30472488|PMID:31953237
Specc1lRatTeebi hypertelorism syndrome 1  ISORGD:16036828554872ClinVar Annotator: match by term: SPECC1L-related condition | ClinVar Annotator: match by term: Teebi hypertelorism more ...ClinVarPMID:25412741|PMID:25741868|PMID:28492532|PMID:30472488|PMID:31953237|PMID:3228142|PMID:32954677|PMID:34302166|PMID:36474027|PMID:39825153
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Original Reference(s)
Specc1lRatoblique facial clefting 1  ISORGD:160368211554173CTD Direct Evidence: marker/mechanismCTD 
Specc1lRatTeebi hypertelorism syndrome 1  ISORGD:160368211554173CTD Direct Evidence: marker/mechanismCTD 
Object Symbol
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Original Reference(s)
Specc1lRatcleft palate  ISSRGD:133201613592920 MouseDO 
Specc1lRatTeebi hypertelorism syndrome 1  ISSRGD:133201613592920OMIM:145420MouseDO 
Object Symbol
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Original Reference(s)
Specc1lRatoblique facial clefting 1  ISORGD:16036827240710 OMIM 
Specc1lRatTeebi hypertelorism syndrome 1  ISORGD:16036827240710 OMIM 

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Original Reference(s)
Specc1lRat17alpha-ethynylestradiol affects expressionISORGD:13320166480464Ethinyl Estradiol affects the expression of SPECC1L mRNACTDPMID:17555576
Specc1lRat17beta-hydroxy-5alpha-androstan-3-one increases expressionISORGD:16036826480464Dihydrotestosterone results in increased expression of SPECC1L mRNACTDPMID:29581250
Specc1lRat2,3,7,8-tetrachlorodibenzodioxine affects expressionISORGD:16036826480464Tetrachlorodibenzodioxin affects the expression of SPECC1L mRNACTDPMID:22298810
Specc1lRat2,3,7,8-tetrachlorodibenzodioxine affects expressionISORGD:13320166480464Tetrachlorodibenzodioxin affects the expression of SPECC1L mRNACTDPMID:21570461
Specc1lRat2-methylcholine affects expressionISORGD:16036826480464beta-methylcholine affects the expression of SPECC1L mRNACTDPMID:21179406
Specc1lRat3,4-methylenedioxymethamphetamine decreases expressionISORGD:13320166480464N-Methyl-3,4-methylenedioxyamphetamine results in decreased expression of SPECC1L mRNACTDPMID:26251327
Specc1lRataflatoxin B1 increases expressionISORGD:13320166480464Aflatoxin B1 results in increased expression of SPECC1L mRNACTDPMID:19770486
Specc1lRatall-trans-retinoic acid decreases expressionISORGD:16036826480464Tretinoin results in decreased expression of SPECC1L mRNACTDPMID:33167477
Specc1lRatantirheumatic drug increases expressionISORGD:16036826480464Antirheumatic Agents results in increased expression of SPECC1L mRNACTDPMID:24449571
Specc1lRatarsane multiple interactionsISORGD:16036826480464[[sodium arsenite results in increased abundance of Arsenic] co-treated with [manganese chloride results in increased more ...CTDPMID:39836092
Specc1lRatarsenic atom multiple interactionsISORGD:16036826480464[[sodium arsenite results in increased abundance of Arsenic] co-treated with [manganese chloride results in increased more ...CTDPMID:39836092
Specc1lRatarsenite(3-) multiple interactionsISORGD:16036826480464arsenite inhibits the reaction [G3BP1 protein binds to SPECC1L mRNA]CTDPMID:32406909
Specc1lRatbis(2-ethylhexyl) phthalate decreases expressionISORGD:13320166480464Diethylhexyl Phthalate results in decreased expression of SPECC1L mRNACTDPMID:33754040
Specc1lRatbisphenol A increases expressionEXP 6480464bisphenol A results in increased expression of SPECC1L mRNACTDPMID:25181051
Specc1lRatbisphenol A decreases expressionEXP 6480464bisphenol A results in decreased expression of SPECC1L mRNACTDPMID:34947998
Specc1lRatcadmium dichloride decreases methylationEXP 6480464Cadmium Chloride results in decreased methylation of SPECC1L promoterCTDPMID:22457795
Specc1lRatcaffeine affects phosphorylationISORGD:16036826480464Caffeine affects the phosphorylation of SPECC1L proteinCTDPMID:35688186
Specc1lRatcarbon nanotube decreases expressionISORGD:13320166480464Nanotubes, Carbon results in decreased expression of SPECC1L mRNACTDPMID:25554681
Specc1lRatchlorpyrifos affects expressionEXP 6480464Chlorpyrifos affects the expression of SPECC1L mRNACTDPMID:26775027
Specc1lRatcisplatin increases expressionISORGD:16036826480464Cisplatin results in increased expression of SPECC1L mRNACTDPMID:27594783

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Biological Process
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Original Reference(s)
Specc1lRatactin cytoskeleton organization involved_inIBAFB:FBgn0025633|MGI:1921642|PANTHER:PTN0046146901600115GO_REF:0000033GO_CentralGO_REF:0000033
Specc1lRatactin cytoskeleton organization acts_upstream_of_or_withinIEAUniProtKB:Q2KN98|ensembl:ENSMUSP000001513221600115GO_REF:0000107EnsemblGO_REF:0000107
Specc1lRatactin cytoskeleton organization acts_upstream_of_or_withinISORGD:13320161624291MGI:4124253 PMID:21703590, PMID:26787558RGDPMID:21703590|PMID:26787558
Specc1lRatadherens junction organization acts_upstream_of_or_withinIEAUniProtKB:Q2KN98|ensembl:ENSMUSP000001513221600115GO_REF:0000107EnsemblGO_REF:0000107
Specc1lRatadherens junction organization acts_upstream_of_or_withinISORGD:13320161624291MGI:4124253 PMID:26787558RGDPMID:26787558
Specc1lRatanterior neural tube closure acts_upstream_of_or_withinIEAUniProtKB:Q2KN98|ensembl:ENSMUSP000001513221600115GO_REF:0000107EnsemblGO_REF:0000107
Specc1lRatanterior neural tube closure acts_upstream_of_or_withinISORGD:13320161624291MGI:4124253|MGI:4128888 PMID:26787558RGDPMID:26787558
Specc1lRatcell adhesion acts_upstream_of_or_withinISORGD:16036821624291 PMID:21703590RGDPMID:21703590
Specc1lRatcell division involved_inIEAUniRule:UR0013767911600115GO_REF:0000104UniProtGO_REF:0000104
Specc1lRatcell division involved_inIEAUniProtKB-KW:KW-01321600115GO_REF:0000043UniProtGO_REF:0000043
Specc1lRatcell migration acts_upstream_of_or_withinISORGD:13320161624291 PMID:21703590RGDPMID:21703590
Specc1lRatcell migration acts_upstream_of_or_withinIEAUniProtKB:Q2KN98|ensembl:ENSMUSP000001513221600115GO_REF:0000107EnsemblGO_REF:0000107
Specc1lRatnegative regulation of actin filament depolymerization acts_upstream_of_or_withinISORGD:13320161624291 PMID:21703590RGDPMID:21703590
Specc1lRatnegative regulation of actin filament depolymerization acts_upstream_of_or_withinIEAUniProtKB:Q2KN98|ensembl:ENSMUSP000001513221600115GO_REF:0000107EnsemblGO_REF:0000107
Specc1lRatnegative regulation of microtubule depolymerization acts_upstream_of_or_withinIEAUniProtKB:Q2KN98|ensembl:ENSMUSP000001513221600115GO_REF:0000107EnsemblGO_REF:0000107
Specc1lRatnegative regulation of microtubule depolymerization acts_upstream_of_or_withinISORGD:13320161624291 PMID:21703590RGDPMID:21703590
Specc1lRatneural crest cell delamination acts_upstream_of_or_withinISORGD:13320161624291MGI:4124253|MGI:4128888 PMID:26787558RGDPMID:26787558
Specc1lRatneural crest cell delamination acts_upstream_of_or_withinIEAUniProtKB:Q2KN98|ensembl:ENSMUSP000001513221600115GO_REF:0000107EnsemblGO_REF:0000107
Specc1lRatpositive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction acts_upstream_of_or_withinISORGD:13320161624291MGI:4124253 PMID:26787558RGDPMID:26787558
Specc1lRatpositive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction acts_upstream_of_or_withinIEAUniProtKB:Q2KN98|ensembl:ENSMUSP000001513221600115GO_REF:0000107EnsemblGO_REF:0000107
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Cellular Component
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Original Reference(s)
Specc1lRatactin cytoskeleton located_inISORGD:1603682|UniProtKB:Q69YQ0-1|UniProtKB:Q69YQ0-21624291 RGDGO_REF:0000052
Specc1lRatactin cytoskeleton located_inIEAUniProtKB:Q2KN98|ensembl:ENSMUSP000001513221600115GO_REF:0000107EnsemblGO_REF:0000107
Specc1lRatactin cytoskeleton located_inISORGD:13320161624291 PMID:21703590RGDPMID:21703590
Specc1lRatanchoring junction located_inIEAUniProtKB-KW:KW-09651600115GO_REF:0000043UniProtGO_REF:0000043
Specc1lRatcell-cell junction located_inIEAUniProtKB:Q2KN98|ensembl:ENSMUSP000001513221600115GO_REF:0000107EnsemblGO_REF:0000107
Specc1lRatcell-cell junction located_inISORGD:13320161624291 PMID:26787558RGDPMID:26787558
Specc1lRatcytoplasm located_inIEAUniProtKB-KW:KW-09631600115GO_REF:0000043UniProtGO_REF:0000043
Specc1lRatcytoplasm located_inISORGD:13320161624291 PMID:26787558RGDPMID:26787558
Specc1lRatcytoplasm located_inIEAUniProtKB:Q2KN98|ensembl:ENSMUSP000001513221600115GO_REF:0000107EnsemblGO_REF:0000107
Specc1lRatcytoplasm located_inIEAUniRule:UR0013767911600115GO_REF:0000104UniProtGO_REF:0000104
Specc1lRatcytoskeleton located_inIEAUniProtKB-SubCell:SL-00901600115GO_REF:0000044UniProtGO_REF:0000044
Specc1lRatcytoskeleton located_inIEAUniProtKB-KW:KW-02061600115GO_REF:0000043UniProtGO_REF:0000043
Specc1lRatfilamentous actin part_ofIBAMGI:1921642|PANTHER:PTN0046146901600115GO_REF:0000033GO_CentralGO_REF:0000033
Specc1lRatfilamentous actin part_ofIEAUniProtKB:Q2KN98|ensembl:ENSMUSP000001513221600115GO_REF:0000107EnsemblGO_REF:0000107
Specc1lRatfilamentous actin part_ofISORGD:13320161624291 PMID:21703590RGDPMID:21703590
Specc1lRatgap junction located_inIEAUniProtKB-SubCell:SL-01241600115GO_REF:0000044UniProtGO_REF:0000044
Specc1lRatgap junction located_inIEAUniRule:UR0013767911600115GO_REF:0000104UniProtGO_REF:0000104
Specc1lRatgap junction located_inIEAUniProtKB-KW:KW-03031600115GO_REF:0000043UniProtGO_REF:0000043
Specc1lRatmicrotubule cytoskeleton located_inIEAUniProtKB:Q2KN98|ensembl:ENSMUSP000001513221600115GO_REF:0000107EnsemblGO_REF:0000107
Specc1lRatmicrotubule cytoskeleton located_inISORGD:13320161624291 PMID:21703590RGDPMID:21703590
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Molecular Function

  
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Original Reference(s)
Specc1lRatbeta-catenin binding enablesIEAUniProtKB:Q2KN98|ensembl:ENSMUSP000001513221600115GO_REF:0000107EnsemblGO_REF:0000107
Specc1lRatbeta-catenin binding enablesISORGD:13320161624291PR:Q02248 PMID:26787558RGDPMID:26787558
Specc1lRatprotein binding enablesISORGD:16036821624291UniProtKB:P15622-3|UniProtKB:Q13573|UniProtKB:Q14241|UniProtKB:Q15911-2|UniProtKB:Q7L622|UniProtKB:Q8N7B9-2|UniProtKB:Q9BZL4 PMID:28514442, PMID:32296183, PMID:33961781RGDPMID:28514442|PMID:32296183|PMID:33961781


#
Reference Title
Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
3. GOA pipeline RGD automated data pipeline
4. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
PMID:21703590   PMID:26787558   PMID:32357304   PMID:35352799  



Specc1l
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82013,337,399 - 13,443,080 (-)NCBIGRCr8
mRatBN7.22013,337,983 - 13,443,665 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2013,339,692 - 13,443,665 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2014,046,241 - 14,150,210 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02013,407,064 - 13,511,031 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02013,879,707 - 13,983,644 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02014,287,470 - 14,393,879 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2014,287,457 - 14,393,793 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02016,470,744 - 16,577,173 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42013,840,439 - 13,945,178 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12013,838,941 - 13,945,405 (-)NCBI
Celera2014,825,150 - 14,929,010 (-)NCBICelera
Cytogenetic Map20p12NCBI
SPECC1L
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382224,270,831 - 24,417,738 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2224,270,817 - 24,417,739 (+)EnsemblGRCh38hg38GRCh38
GRCh372224,666,799 - 24,813,706 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362222,996,866 - 23,143,221 (+)NCBINCBI36Build 36hg18NCBI36
Celera228,467,175 - 8,613,432 (+)NCBICelera
Cytogenetic Map22q11.23NCBI
HuRef227,616,847 - 7,763,724 (+)NCBIHuRef
CHM1_12224,625,424 - 24,772,401 (+)NCBICHM1_1
T2T-CHM13v2.02224,732,441 - 24,879,351 (+)NCBIT2T-CHM13v2.0
Specc1l
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391075,047,872 - 75,148,234 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1075,047,905 - 75,148,577 (+)EnsemblGRCm39 Ensembl
GRCm381075,212,037 - 75,312,400 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1075,212,073 - 75,312,743 (+)EnsemblGRCm38mm10GRCm38
MGSCv371074,674,818 - 74,775,145 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361074,674,412 - 74,756,109 (+)NCBIMGSCv36mm8
Celera1076,258,909 - 76,359,489 (+)NCBICelera
Cytogenetic Map10C1NCBI
cM Map1038.51NCBI
Specc1l
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554557,739,463 - 7,882,427 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554557,739,105 - 7,879,489 (+)NCBIChiLan1.0ChiLan1.0
SPECC1L
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22334,057,976 - 34,206,240 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12236,791,660 - 36,937,339 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0225,078,435 - 5,224,090 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12221,943,630 - 22,089,686 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2221,943,630 - 22,089,686 (+)Ensemblpanpan1.1panPan2
SPECC1L
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12627,994,278 - 28,127,383 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2628,025,987 - 28,125,695 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2627,101,372 - 27,201,064 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02629,398,465 - 29,531,216 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2629,398,488 - 29,531,202 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12627,513,613 - 27,612,876 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02627,130,906 - 27,230,482 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02628,119,986 - 28,219,566 (+)NCBIUU_Cfam_GSD_1.0
Specc1l
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118142,161,078 - 142,305,767 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936619448,303 - 593,001 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936619448,304 - 592,981 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SPECC1L
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1449,333,009 - 49,463,963 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11449,332,937 - 49,463,965 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21452,782,692 - 52,909,765 (+)NCBISscrofa10.2Sscrofa10.2susScr3
SPECC1L
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1197,488,821 - 7,539,961 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl197,488,832 - 7,539,952 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660854,919,762 - 5,063,070 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Specc1l
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247479,705,081 - 9,837,535 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247479,687,369 - 9,837,344 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

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Variants in Specc1l
527 total Variants

Predicted Target Of
Summary Value
Count of predictions:119
Count of miRNA genes:88
Interacting mature miRNAs:101
Transcripts:ENSRNOT00000001764
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 26 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
4889870Pur30Proteinuria QTL 30190.005urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)20804241029322208Rat
1354642Despr15Despair related QTL 150.0027locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)20124159021Rat
4889857Pur27Proteinuria QTL 2712.20.001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)20460660717617956Rat
70154Insul2Insulin level QTL 23.75blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)20669170617489458Rat
9590109Sffal8Serum free fatty acids level QTL 85.320.01blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)20129191651Rat
9590275Scort15Serum corticosterone level QTL 153.480.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)20129191651Rat
1581577Pur15Proteinuria QTL 154.380.0002urine total protein amount (VT:0000032)urine protein excretion rate (CMO:0000759)20804241017617956Rat
6893685Bw111Body weight QTL 1112.70.004body mass (VT:0001259)body weight (CMO:0000012)20132578807Rat
9590092Insglur9Insulin/glucose ratio QTL 918.380.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)201175751554435887Rat
1641915Colcr9Colorectal carcinoma resistance QTL 92.970.0024intestine integrity trait (VT:0010554)benign colorectal tumor number (CMO:0001795)20153065546530655Rat

1 to 10 of 26 rows
RH132515  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr82013,339,366 - 13,339,583 (+)Marker Load Pipeline
mRatBN7.22013,339,950 - 13,340,167 (+)MAPPERmRatBN7.2
Rnor_6.02014,289,438 - 14,289,654NCBIRnor6.0
Rnor_5.02016,472,712 - 16,472,928UniSTSRnor5.0
RGSC_v3.42013,840,696 - 13,840,912UniSTSRGSC3.4
Celera2014,825,407 - 14,825,623UniSTS
RH 3.4 Map20154.39UniSTS
Cytogenetic Map20p12UniSTS
RH125059  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22013,345,259 - 13,346,323 (+)MAPPERmRatBN7.2
mRatBN7.2837,172,781 - 37,173,497 (+)MAPPERmRatBN7.2
Rnor_6.0839,932,102 - 39,932,817NCBIRnor6.0
Rnor_6.02014,294,748 - 14,295,811NCBIRnor6.0
Rnor_5.02016,478,022 - 16,479,085UniSTSRnor5.0
Rnor_5.0839,932,926 - 39,933,641UniSTSRnor5.0
RGSC_v3.4838,707,724 - 38,708,439UniSTSRGSC3.4
RGSC_v3.42013,846,006 - 13,847,069UniSTSRGSC3.4
Celera2014,830,717 - 14,831,780UniSTS
Celera837,281,381 - 37,282,096UniSTS
Cytogenetic Map20p12UniSTS




alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31



Ensembl Acc Id: ENSRNOT00000001764   ⟹   ENSRNOP00000001764
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2013,339,692 - 13,443,665 (-)Ensembl
Rnor_6.0 Ensembl2014,287,457 - 14,393,793 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000103283   ⟹   ENSRNOP00000081153
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2013,339,692 - 13,430,130 (-)Ensembl
RefSeq Acc Id: NM_001039455   ⟹   NP_001034544
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82013,339,110 - 13,443,070 (-)NCBI
mRatBN7.22013,339,694 - 13,443,665 (-)NCBI
Rnor_6.02014,289,181 - 14,393,872 (-)NCBI
Rnor_5.02016,470,744 - 16,577,173 (-)NCBI
RGSC_v3.42013,840,439 - 13,945,178 (-)RGD
Celera2014,825,150 - 14,929,010 (-)RGD
Sequence:
RefSeq Acc Id: XM_006256339   ⟹   XP_006256401
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82013,337,399 - 13,442,788 (-)NCBI
mRatBN7.22013,337,983 - 13,443,382 (-)NCBI
Rnor_6.02014,287,470 - 14,393,576 (-)NCBI
Rnor_5.02016,470,744 - 16,577,173 (-)NCBI
Sequence:
RefSeq Acc Id: XM_063279246   ⟹   XP_063135316
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82013,337,399 - 13,443,080 (-)NCBI
RefSeq Acc Id: XM_063279247   ⟹   XP_063135317
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82013,337,399 - 13,442,790 (-)NCBI
1 to 9 of 9 rows
Protein RefSeqs NP_001034544 (Get FASTA)   NCBI Sequence Viewer  
  XP_006256401 (Get FASTA)   NCBI Sequence Viewer  
  XP_063135316 (Get FASTA)   NCBI Sequence Viewer  
  XP_063135317 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAX84187 (Get FASTA)   NCBI Sequence Viewer  
  EDL97232 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000001764
  ENSRNOP00000001764.4
GenBank Protein Q2KN99 (Get FASTA)   NCBI Sequence Viewer  
1 to 9 of 9 rows
RefSeq Acc Id: NP_001034544   ⟸   NM_001039455
- UniProtKB: Q2KN99 (UniProtKB/Swiss-Prot),   A6JKL5 (UniProtKB/TrEMBL),   A0A8I5ZSC5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006256401   ⟸   XM_006256339
- Peptide Label: isoform X2
- UniProtKB: Q2KN99 (UniProtKB/Swiss-Prot),   A6JKL5 (UniProtKB/TrEMBL),   A0A8I5ZSC5 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000001764   ⟸   ENSRNOT00000001764
Ensembl Acc Id: ENSRNOP00000081153   ⟸   ENSRNOT00000103283
RefSeq Acc Id: XP_063135316   ⟸   XM_063279246
- Peptide Label: isoform X1
- UniProtKB: A0A8I5ZSC5 (UniProtKB/TrEMBL)
Calponin-homology (CH)

Name Modeler Protein Id AA Range Protein Structure
AF-Q2KN99-F1-model_v2 AlphaFold Q2KN99 1-1118 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13701544
Promoter ID:EPDNEW_R12068
Type:initiation region
Name:Specc1l_1
Description:sperm antigen with calponin homology and coiled-coil domains1-like
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.02014,393,804 - 14,393,864EPDNEW


1 to 21 of 21 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-4107 BioCyc
Ensembl Genes ENSRNOG00000001303 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000001764 ENTREZGENE
  ENSRNOT00000001764.6 UniProtKB/Swiss-Prot
Gene3D-CATH 1.10.418.10 UniProtKB/Swiss-Prot
InterPro CH-domain UniProtKB/Swiss-Prot
  CH_dom_sf UniProtKB/Swiss-Prot
  F-actin_Monoox_Mical UniProtKB/Swiss-Prot
KEGG Report rno:361828 UniProtKB/Swiss-Prot
NCBI Gene 361828 ENTREZGENE
PANTHER CALPONIN HOMOLOGY DOMAIN-CONTAINING PROTEIN DDB_G0272472-RELATED UniProtKB/Swiss-Prot
  PTHR23167:SF18 UniProtKB/Swiss-Prot
Pfam PF00307 UniProtKB/Swiss-Prot
PhenoGen Specc1l PhenoGen
PROSITE PS50021 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000001303 RatGTEx
SMART SM00033 UniProtKB/Swiss-Prot
Superfamily-SCOP SSF47576 UniProtKB/Swiss-Prot
UniProt A0A8I5ZSC5 ENTREZGENE, UniProtKB/TrEMBL
  A6JKL5 ENTREZGENE, UniProtKB/TrEMBL
  CYTSA_RAT UniProtKB/Swiss-Prot, ENTREZGENE
1 to 21 of 21 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-07-29 Specc1l  sperm antigen with calponin homology and coiled-coil domains 1-like  LOC102546441  28S ribosomal protein S7, mitochondrial-like  Data merged from RGD:7738849 737654 PROVISIONAL
2013-12-18 LOC102546441  28S ribosomal protein S7, mitochondrial-like      Symbol and Name status set to provisional 70820 PROVISIONAL
2011-08-02 Specc1l  sperm antigen with calponin homology and coiled-coil domains 1-like  Cytsa  cytospin A  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2010-05-05 Cytsa  cytospin A  Specc1l  SPECC1-like  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-02-26 Specc1l  SPECC1-like  RGD1309570  similar to mKIAA0376 protein  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-07 RGD1309570  similar to mKIAA0376 protein  RGD1309570_predicted  similar to mKIAA0376 protein (predicted)  Symbol and Name status set to approved 1299863 APPROVED
2005-01-20 RGD1309570_predicted  similar to mKIAA0376 protein (predicted)  LOC361828_predicted    Symbol and Name status set to approved 1331353 APPROVED
2005-01-12 LOC361828_predicted  similar to mKIAA0376 protein (predicted)      Symbol and Name status set to provisional 70820 PROVISIONAL