Ddit4 (DNA-damage-inducible transcript 4)

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Gene: Ddit4 (DNA-damage-inducible transcript 4) Rattus norvegicus

Analyze

Symbol:

Ddit4

Name:

DNA-damage-inducible transcript 4

RGD ID:

621731

Description:

Predicted to have 14-3-3 protein binding activity. Involved in several processes, including negative regulation of protein phosphorylation; nervous system development; and neurotrophin TRK receptor signaling pathway. Predicted to localize to cytosol and mitochondrion. Orthologous to human DDIT4 (DNA damage inducible transcript 4); PARTICIPATES IN mTOR signaling pathway; INTERACTS WITH 1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane; 1,2,4-trimethylbenzene; 1,3-dinitrobenzene.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Also known as:

DNA damage-inducible transcript 4 protein; DNA-damage-inducible transcript 4 protein; HIF-1 responsive protein RTP801; HIF-1 responsive RTP801; protein regulated in development and DNA damage response 1; REDD-1; Rtp801

RGD Orthologs

Human

Mouse

Chinchilla

Bonobo

Dog

Squirrel

Pig

Green Monkey

Naked Mole-Rat

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	DDIT4 (DNA damage inducible transcript 4)	HGNC	Ensembl, HomoloGene, Inparanoid, NCBI, Panther
Mus musculus (house mouse):	Ddit4 (DNA-damage-inducible transcript 4)	HGNC	NCBI, HomoloGene, Inparanoid, Panther, Ensembl
Chinchilla lanigera (long-tailed chinchilla):	Ddit4 (DNA damage inducible transcript 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	DDIT4 (DNA damage inducible transcript 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	DDIT4 (DNA damage inducible transcript 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Ddit4 (DNA damage inducible transcript 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	DDIT4 (DNA damage inducible transcript 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (African green monkey):	DDIT4 (DNA damage inducible transcript 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Ddit4 (DNA damage inducible transcript 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Mus musculus (house mouse):	Ddit4 (DNA-damage-inducible transcript 4)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB)
Homo sapiens (human):	DDIT4 (DNA damage inducible transcript 4)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB)
Danio rerio (zebrafish):	ddit4 (DNA-damage-inducible transcript 4)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB)
Drosophila melanogaster (fruit fly):	scyl	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB)
Drosophila melanogaster (fruit fly):	chrb	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB)

Latest Assembly:

Rnor_6.0 - RGSC Genome Assembly v6.0

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	20	27,891,989 - 27,894,088 (-)	NCBI
Rnor_6.0 Ensembl	20	29,509,289 - 29,511,382 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_6.0	20	29,509,283 - 29,511,382 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_5.0	20	31,315,024 - 31,317,123 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	20	27,252,273 - 27,254,371 (-)	NCBI	RGSC3.4		rn4	RGSC3.4
RGSC_v3.1	20	27,266,073 - 27,268,171 (-)	NCBI
Celera	20	29,333,162 - 29,335,357 (-)	NCBI		Celera
Cytogenetic Map	20	q11	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

COVID-19 (ISO)

leukemia (ISO)

mouth disease (ISO)

Nerve Degeneration (ISO)

Parkinson's disease (ISO)

rheumatoid arthritis (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(S)-colchicine (ISO)

(S)-nicotine (ISO)

1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane (EXP)

1,2,4-trimethylbenzene (EXP)

1,3-dinitrobenzene (EXP)

14-Deoxy-11,12-didehydroandrographolide (ISO)

17alpha-ethynylestradiol (ISO)

17beta-estradiol (ISO)

2,2',4,4'-Tetrabromodiphenyl ether (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2,4-dinitrotoluene (EXP)

2-butoxyethanol (ISO)

2-methylcholine (ISO)

3,4-methylenedioxymethamphetamine (ISO)

3-phenylprop-2-enal (ISO)

4,4'-sulfonyldiphenol (ISO)

4-hydroxynon-2-enal (ISO)

4-hydroxyphenyl retinamide (ISO)

5-fluorouracil (ISO)

6-propyl-2-thiouracil (EXP)

6alpha-methylprednisolone (EXP)

7,12-dimethyltetraphene (ISO)

acetamide (EXP)

acrylamide (EXP,ISO)

adenine (ISO)

afimoxifene (ISO)

aflatoxin B1 (EXP,ISO)

all-trans-retinoic acid (EXP,ISO)

AM-251 (ISO)

amino acid (ISO)

amiodarone (ISO)

ammonium chloride (EXP)

anthracen-2-amine (EXP)

arachidonic acid (ISO)

arecoline (ISO)

arsenite(3-) (ISO)

arsenous acid (ISO)

atrazine (ISO)

Azaspiracid (ISO)

bafilomycin A1 (EXP)

benzene-1,2,4-triol (ISO)

benzo[a]pyrene (ISO)

benzo[a]pyrene diol epoxide I (ISO)

beta-naphthoflavone (ISO)

bexarotene (ISO)

bicalutamide (EXP)

bis(2-ethylhexyl) phthalate (ISO)

bisphenol A (EXP,ISO)

Bisphenol B (ISO)

bleomycin A5 (ISO)

C60 fullerene (EXP)

cadmium dichloride (ISO)

cannabidiol (ISO)

carbon nanotube (ISO)

carvedilol (ISO)

cefaloridine (EXP)

celastrol (ISO)

chloroacetaldehyde (ISO)

chloropicrin (ISO)

chlorpyrifos (EXP,ISO)

choline (ISO)

cidofovir anhydrous (ISO)

ciguatoxin CTX1B (ISO)

cisplatin (ISO)

clodronic acid (ISO)

clofibrate (ISO)

cobalt dichloride (EXP,ISO)

copper atom (ISO)

copper(0) (ISO)

copper(II) sulfate (ISO)

coumestrol (ISO)

crocidolite asbestos (ISO)

cycloheximide (EXP)

cyclophosphamide (ISO)

cyclosporin A (EXP,ISO)

deoxynivalenol (ISO)

dexamethasone (EXP,ISO)

diarsenic trioxide (ISO)

diazinon (EXP)

dibutyl phthalate (EXP)

dichloroacetic acid (ISO)

diclofenac (ISO)

dieldrin (EXP)

diethyldithiocarbamic acid (EXP)

diethylstilbestrol (ISO)

dinophysistoxin 1 (ISO)

dioxygen (ISO)

diuron (EXP)

dorsomorphin (ISO)

doxorubicin (ISO)

doxycycline (ISO)

endosulfan (ISO)

ethanol (ISO)

Ethylenethiourea (EXP)

etoposide (ISO)

fenofibrate (EXP,ISO)

ferric oxide (ISO)

fluoranthene (ISO)

flusilazole (ISO)

folic acid (ISO)

folpet (ISO)

formaldehyde (ISO)

gedunin (ISO)

gemcitabine (ISO)

genistein (ISO)

glycidol (EXP)

glyphosate (ISO)

gold atom (ISO)

gold(0) (ISO)

GW 501516 (ISO)

helenalin (ISO)

hexaconazole (ISO)

hexanal (EXP)

hydrogen peroxide (ISO)

hydroquinone (ISO)

ifosfamide (ISO)

Indeno[1,2,3-cd]pyrene (ISO)

irinotecan (EXP)

isobutanol (ISO)

isoprenaline (ISO)

L-methionine (ISO)

lead diacetate (ISO)

leflunomide (ISO)

lipopolysaccharide (EXP)

LY294002 (ISO)

mancozeb (EXP)

maneb (EXP)

menadione (ISO)

metformin (EXP,ISO)

methamphetamine (EXP,ISO)

methapyrilene (EXP)

methotrexate (ISO)

methylmercury chloride (ISO)

methylparaben (ISO)

microcystin-LR (ISO)

mifepristone (EXP,ISO)

mithramycin (ISO)

mitomycin C (ISO)

mitoxantrone (ISO)

motexafin gadolinium (ISO)

N-acetyl-L-cysteine (ISO)

N-methyl-4-phenylpyridinium (ISO)

N-nitrosodiethylamine (EXP)

N1'-[2-[[5-[(dimethylamino)methyl]-2-furanyl]methylthio]ethyl]-N1-methyl-2-nitroethene-1,1-diamine (EXP)

naphthalene (ISO)

nickel dichloride (EXP,ISO)

nickel sulfate (ISO)

nicotine (ISO)

ochratoxin A (ISO)

orlistat (ISO)

oxaliplatin (EXP)

ozone (ISO)

paracetamol (EXP,ISO)

paraquat (ISO)

perfluorononanoic acid (ISO)

perfluorooctane-1-sulfonic acid (EXP)

phenformin (EXP)

phenobarbital (ISO)

picene (ISO)

pioglitazone (ISO)

pirinixic acid (ISO)

pregnenolone 16alpha-carbonitrile (ISO)

progesterone (ISO)

propiconazole (ISO)

quercetin (ISO)

quinolin-8-ol (ISO)

raloxifene (ISO)

ranitidine (EXP)

resveratrol (EXP,ISO)

Salidroside (EXP)

Salinomycin (ISO)

SB 203580 (ISO)

SB 431542 (ISO)

SCH 23390 (EXP)

silicon dioxide (ISO)

silver atom (ISO)

silver(0) (ISO)

sodium arsenite (ISO)

sodium dichromate (EXP)

sorafenib (ISO)

streptozocin (EXP)

sunitinib (ISO)

tamoxifen (ISO)

tert-butyl hydroperoxide (ISO)

Tesaglitazar (EXP)

testosterone (EXP)

tetrachloromethane (EXP,ISO)

titanium dioxide (EXP,ISO)

topotecan (EXP,ISO)

triacsin C (ISO)

triadimefon (ISO)

tributylstannane (ISO)

Tributyltin oxide (ISO)

trichloroethene (ISO)

trichostatin A (ISO)

triphenyl phosphate (EXP)

tris(2-butoxyethyl) phosphate (ISO)

troglitazone (EXP,ISO)

tunicamycin (ISO)

urethane (ISO)

valdecoxib (EXP)

valproic acid (ISO)

vancomycin (ISO)

vanillin (ISO)

vinclozolin (EXP)

withaferin A (ISO)

Yessotoxin (ISO)

zinc acetate (ISO)

zinc atom (EXP)

zinc sulfate (EXP)

zinc(0) (EXP)

zoledronic acid (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

apoptotic process (IBA,IDA)

brain development (IMP)

cellular response to dexamethasone stimulus (IEA,ISO)

defense response to virus (IEA,ISO)

intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator (IEA,ISO,ISS)

negative regulation of glycolytic process (IEA,ISO)

negative regulation of intracellular signal transduction (IMP)

negative regulation of peptidyl-serine phosphorylation (IMP)

negative regulation of peptidyl-threonine phosphorylation (IMP)

negative regulation of TOR signaling (IBA,IEA,IMP,ISO)

neuron differentiation (IMP)

neuron migration (IMP)

neurotrophin TRK receptor signaling pathway (IMP)

positive regulation of neuron death (IMP)

protein-containing complex disassembly (IEA,ISO)

reactive oxygen species metabolic process (IEA,ISO)

regulation of TOR signaling (IBA)

response to hypoxia (IBA,IDA,IEA,ISO)

Cellular Component

cytoplasm (ISO,ISS)

cytosol (IEA,ISO)

mitochondrion (IEA,ISO)

Molecular Function

14-3-3 protein binding (IBA,IEA,ISO)

protein binding (ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

mTOR signaling pathway (IEA,ISO)

References

References - curated


1.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Jiang Y, etal., J Cereb Blood Flow Metab 2002 Jun;22(6):689-96.
3.	Malagelada C, etal., J Neurosci. 2008 Dec 31;28(53):14363-71. doi: 10.1523/JNEUROSCI.3928-08.2008.
4.	Malagelada C, etal., J Neurosci. 2011 Mar 2;31(9):3186-96. doi: 10.1523/JNEUROSCI.4011-10.2011.
5.	NCBI rat LocusLink and RefSeq merged data July 26, 2002
6.	Pipeline to import KEGG annotations from KEGG into RGD
7.	Pipeline to import Pathway Interaction Database annotations from NCI into RGD
8.	RGD automated import pipeline for gene-chemical interactions
9.	Shoshani T, etal., Mol Cell Biol 2002 Apr;22(7):2283-93.
10.	Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.

Additional References at PubMed

PMID:12453409	PMID:17005863	PMID:17074751	PMID:17556672	PMID:18198340	PMID:18336631	PMID:18850054	PMID:19127203	PMID:19297425	PMID:20032058	PMID:20166753	PMID:20176937
PMID:21192293	PMID:21272563	PMID:21410687	PMID:21478870	PMID:21896779	PMID:23978538	PMID:24018049	PMID:24458146	PMID:24691733	PMID:25101677	PMID:25450383	PMID:25876513
PMID:27105917	PMID:27233899	PMID:32732871

Genomics

Comparative Map Data

Ddit4
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	20	27,891,989 - 27,894,088 (-)	NCBI
Rnor_6.0 Ensembl	20	29,509,289 - 29,511,382 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_6.0	20	29,509,283 - 29,511,382 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_5.0	20	31,315,024 - 31,317,123 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	20	27,252,273 - 27,254,371 (-)	NCBI	RGSC3.4		rn4	RGSC3.4
RGSC_v3.1	20	27,266,073 - 27,268,171 (-)	NCBI
Celera	20	29,333,162 - 29,335,357 (-)	NCBI		Celera
Cytogenetic Map	20	q11	NCBI

DDIT4
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38.p13 Ensembl	10	72,273,919 - 72,276,036 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh38.p13 Ensembl	10	72,273,924 - 72,276,036 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh38	10	72,273,924 - 72,276,036 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh37	10	74,033,682 - 74,035,794 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	10	73,703,683 - 73,705,803 (+)	NCBI	NCBI36		hg18	NCBI36
Build 34	10	73,703,682 - 73,705,803	NCBI
Celera	10	67,317,429 - 67,319,550 (+)	NCBI
Cytogenetic Map	10	q22.1	ENTREZGENE
HuRef	10	68,028,151 - 68,030,271 (+)	NCBI		HuRef
CHM1_1	10	74,315,457 - 74,317,577 (+)	NCBI		CHM1_1

Ddit4
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	10	59,785,497 - 59,787,592 (-)	NCBI	GRCm39		mm39
GRCm39 Ensembl	10	59,785,491 - 59,787,656 (-)	Ensembl
GRCm38	10	59,949,675 - 59,951,770 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	10	59,949,669 - 59,951,834 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	10	59,412,423 - 59,414,518 (-)	NCBI	GRCm37		mm9	NCBIm37
MGSCv36	10	59,345,032 - 59,347,127 (-)	NCBI			mm8
Celera	10	61,046,891 - 61,048,986 (-)	NCBI		Celera
Cytogenetic Map	10	B4	NCBI

Ddit4
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955437	19,322,407 - 19,324,562 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955437	19,322,407 - 19,324,562 (-)	NCBI	ChiLan1.0	ChiLan1.0

DDIT4
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
PanPan1.1	10	71,264,028 - 71,266,155 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	10	71,264,029 - 71,266,149 (+)	Ensembl	panpan1.1		panPan2
Mhudiblu_PPA_v0	10	68,796,712 - 68,798,840 (+)	NCBI	Mhudiblu_PPA_v0		panPan3

DDIT4
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	4	22,916,718 - 22,918,893 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	4	22,916,096 - 22,964,035 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	4	23,053,206 - 23,055,382 (+)	NCBI
ROS_Cfam_1.0	4	23,196,970 - 23,199,141 (+)	NCBI
UMICH_Zoey_3.1	4	23,097,917 - 23,100,093 (+)	NCBI
UNSW_CanFamBas_1.0	4	23,298,834 - 23,301,011 (+)	NCBI
UU_Cfam_GSD_1.0	4	23,652,232 - 23,654,408 (+)	NCBI

Ddit4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024407213	58,154,142 - 58,156,276 (-)	NCBI
SpeTri2.0	NW_004936521	6,646,864 - 6,648,982 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

DDIT4
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	14	75,117,707 - 75,119,903 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	14	75,117,708 - 75,119,907 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1

DDIT4
(Chlorocebus sabaeus - African green monkey)

Vervet Assembly	Chr	Position (strand)	Source	Genome Browsers
Vervet Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	9	59,033,058 - 59,035,157 (-)	NCBI
ChlSab1.1 Ensembl	9	59,032,755 - 59,035,241 (-)	Ensembl

Ddit4
(Heterocephalus glaber - naked mole-rat)

Molerat Assembly	Chr	Position (strand)	Source	Genome Browsers
Molerat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla 1.0	NW_004624754	6,091,914 - 6,094,035 (+)	NCBI

Position Markers

RH132188

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	20	27,892,211 - 27,892,418 (+)	MAPPER
Rnor_6.0	20	29,509,506 - 29,509,712	NCBI	Rnor6.0
Rnor_5.0	20	31,315,247 - 31,315,453	UniSTS	Rnor5.0
Cytogenetic Map	20	q11	UniSTS

QTLs in Region (Rnor_6.0)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
6893685	Bw111	Body weight QTL 111	2.7	0.004	body mass (VT:0001259)	body weight (CMO:0000012)	20	1	33300419	Rat
9590252	Scort12	Serum corticosterone level QTL 12	20.46	0.001	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	20	1	37550487	Rat
7411668	Foco32	Food consumption QTL 32	8	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	20	1	37550487	Rat
2305926	Iddm37	Insulin dependent diabetes mellitus QTL 37	6		blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	20	2018654	47018654	Rat
1641915	Colcr9	Colorectal carcinoma resistance QTL 9	2.97	0.0024	intestine integrity trait (VT:0010554)	benign colorectal tumor number (CMO:0001795)	20	2999707	47999707	Rat
1598816	Memor12	Memory QTL 12	2.4		exploratory behavior trait (VT:0010471)	average horizontal distance in proximity to the target during voluntary locomotion in an experimental apparatus (CMO:0002674)	20	4108956	49108956	Rat
4889870	Pur30	Proteinuria QTL 30	19	0.005	total urine protein amount (VT:0000032)	urine total protein excretion rate (CMO:0000756)	20	8654341	30991290	Rat
9590092	Insglur9	Insulin/glucose ratio QTL 9	18.38	0.001	blood insulin amount (VT:0001560)	calculated plasma insulin level (CMO:0002170)	20	13834309	56205956	Rat
7411652	Foco24	Food consumption QTL 24		0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	20	13834309	56205956	Rat
2317880	Alcrsp25	Alcohol response QTL 25	2.3		response to alcohol trait (VT:0010489)	duration of loss of righting reflex (CMO:0002289)	20	17827096	56205956	Rat
4889610	Pancm3	Pancreatic morphology QTL 3	3.75	0.001	pancreas mass (VT:0010144)	pancreas wet weight (CMO:0000626)	20	18872150	49108956	Rat
2303626	Vencon10	Ventilatory control QTL 10		0.001	respiration trait (VT:0001943)	respiration rate (CMO:0000289)	20	20858470	56205956	Rat
2303578	Gluco50	Glucose level QTL 50	2		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	20	26608843	56205956	Rat
2303587	Bw93	Body weight QTL 93	13		body mass (VT:0001259)	body weight (CMO:0000012)	20	26608843	56205956	Rat
2300188	Bmd68	Bone mineral density QTL 68	6.4	0.0001	femur mineral mass (VT:0010011)	volumetric bone mineral density (CMO:0001553)	20	26608843	56205956	Rat
1331747	Hrtrt16	Heart rate QTL 16	3.163		heart pumping trait (VT:2000009)	heart rate (CMO:0000002)	20	26712323	56205956	Rat

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	416
Count of miRNA genes:	236
Interacting mature miRNAs:	295
Transcripts:	ENSRNOT00000000703
Prediction methods:	Microtar, Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium	3	33	17	10	17	10		3	66	27	32	3
Low		10	40	31	2	31	8	8	8	8	9	8	8
Below cutoff

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_080906	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC096404	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AF334162	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC062021	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH474016	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JACYVU010000324	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Reference Sequences

RefSeq Acc Id:

ENSRNOT00000085026 ⟹ ENSRNOP00000073198

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0 Ensembl	20	29,509,289 - 29,511,382 (-)	Ensembl

RefSeq Acc Id:

NM_080906 ⟹ NP_543182

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	20	27,891,989 - 27,894,088 (-)	NCBI
Rnor_6.0	20	29,509,283 - 29,511,382 (-)	NCBI
Rnor_5.0	20	31,315,024 - 31,317,123 (-)	NCBI
RGSC_v3.4	20	27,252,273 - 27,254,371 (-)	RGD
Celera	20	29,333,162 - 29,335,357 (-)	RGD

Sequence:

show sequence

GGGGGAGGTGCGAGAGGGCTGGAAAGGACAGGTCCGGGCAGCGATCGGGGGTTGGCATCAGTTC
GCTCACCCTTCGAGAGGCAGATCGCTCTTGTCCGCAATCTTCGCTGACCGCGCTAGCTGCGGCT
TCTGTGCTCCTTCGCCGAACCTCATCAACCAGCGTCCTGGCGTCTGACCTCGCCATGCCTAGCC
TTTGGGATCGTTTCTCGTCCTCCTCTTCCTCTTCGTCCTCGTCCCGAACTCCGGCCGCTGATCG
GCCGCCGCGCTCCGCCTGGGGGTCTGCGGCCAGAGAAGAGGGCCTTGACCGCTGCGCGAGCCTG
GAGAGCTCGGACTGCGAGTCCCTGGACAGCAGCAACAGTGGCTTTGGGCCGGAGGAAGACTCCT
CATACCTGGATGGGGTGTCTCTGCCTGACTTTGAGCTGCTCAGTGACCCCGAGGATGAGCACCT
GTGTGCCAACCTGATGCAGCTGCTGCAGGAGAGCCTGTCCCAGGCGCGATTGGGCTCGCGGCGC
CCTGCGCGCCTGCTGATGCCGAGCCAGCTGTTGAGCCAGGTGGGCAAGGAACTCCTGCGCCTGG
CGTACAGCGAGCCGTGCGGCCTGCGGGGGGCACTGCTGGACGTCTGTGTGGAGCAAGGCAAGAG
CTGCCATAGTGTGGCTCAGCTGGCTCTGGACCCCAGTCTAGTGCCCACCTTTCAGTTGACCCTG
GTGCTGCGTCTGGACTCTCGCCTCTGGCCCAAGATCCAGGGCCTGTTGAGTTCTGCCAACTCTT
CCTTGGTCCCTGGTTACAGCCAGTCCCTGACGCTGAGCACCGGCTTCAGAGTCATCAAAAAGAA
ACTCTACAGCTCCGAGCAGCTGCTCATTGAAGAGTGTTGAACTTCGTCCTGGAGGGGGGCCGCA
CTGCCCCCCAAAGTGGAGACAAGGAATTTCTGTGGTGGAGACCCGCAGGCAAGGACTGAAGGAC
TGTCCCCTGTGTTAGAAAACTGACAATAGCCACCGGAGGGGCGCAGGGCCAGGTGGGAGAAGGA
AGTGTTGTCCAGGAAGTCTCTAGGTTGTGTGCAGGTGGCCCCCTGTTGGGGCACATGCCCCTCA
GTACTGTAGCATGAAACAAAGGCTTCGGAGCCACACAGGCTTCTGGCTGGATGTGTATGTAGCA
TGTATCTTATTAATTTTTGTATTACTGACAAGTTACAACAGCAGTTGTGGGCCAGAGTCAGAAG
GGCAGCTGGTCTGCACTGGCCTCTGCCCGGGCTGTGTGCTGGGGGGAGGCGGGGGGAGGTCTCC
GACAGTTTGTCGACAGATCTCATGGTCTGAAAGGACCGAGCTTGTTCGTCGTTTGGTTTGTATC
TTGTTTTGGGGGTGGGGTGGGGGGATCGGAGCTTCACTACTGACCTGTTCGAGGCAGCTATCTT
ACAGACTGCATGAATGTAAGAATAGGAAGGGGGTGGGTGTTAGGATCATTTGGGATCTTCAACA
CTTGAAACAAAATAACACCAGGGAGCTGCATCCCAGCCCATCCCGGTGCCGGTGTACTGGAGGA
GTGAACTGTGAGGGGATGGGGCTGAGGGGGGTGGGGGGCTGGAACCCTCTCCCCCAGAGGAGCG
CCACCTGGGTCTTCCATCTAGAACTGTTTACATGAAGATACTCACGGTTCATGAATACACTTGA
TGTTCAAGTACTAAGACCTATGCAATATTTTTACTTTTCTAATAAACATGTTTGTTAAAACAAA
AAAAAAAAAAAAAAAAAAAAA

hide sequence

Protein Sequences


Protein RefSeqs	NP_543182	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAH62021	(Get FASTA)	NCBI Sequence Viewer
	AAL38423	(Get FASTA)	NCBI Sequence Viewer
	EDL93064	(Get FASTA)	NCBI Sequence Viewer
	Q8VHZ9	(Get FASTA)	NCBI Sequence Viewer

Reference Sequences

RefSeq Acc Id:

NP_543182 ⟸ NM_080906

- UniProtKB:

Q8VHZ9 (UniProtKB/Swiss-Prot)

- Sequence:

show sequence

MPSLWDRFSSSSSSSSSSRTPAADRPPRSAWGSAAREEGLDRCASLESSDCESLDSSNSGFGPE
EDSSYLDGVSLPDFELLSDPEDEHLCANLMQLLQESLSQARLGSRRPARLLMPSQLLSQVGKEL
LRLAYSEPCGLRGALLDVCVEQGKSCHSVAQLALDPSLVPTFQLTLVLRLDSRLWPKIQGLLSS
ANSSLVPGYSQSLTLSTGFRVIKKKLYSSEQLLIEEC

hide sequence

RefSeq Acc Id:

ENSRNOP00000073198 ⟸ ENSRNOT00000085026

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13701594

Promoter ID:

EPDNEW_R12117

Type:

single initiation site

Name:

Ddit4_1

Description:

DNA-damage-inducible transcript 4

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	20	29,511,396 - 29,511,456	EPDNEW

Strain Variation

Strain Sequence Variants (Rnor 6.0)

ACI/EurMcwi (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

ACI/EurMcwi (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

ACI/N (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

BBDP/Wor (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

BN/SsN (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Buf/N (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

COP/CrCrl (MCW & UW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob) University of Wisconsin (Dr. James Shull)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Charles River Laboratories
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)

F344/NCrl (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

F344/NRrrc (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

FHH/EurMcwi (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

FHH/EurMcwi (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

FHL/EurMcwi (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

FHL/EurMcwi (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

GH/OmrMcwi (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

GK/Ox (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LE/Stm (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LEW/Crl (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LEW/NCrlBR (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LH/MavRrrc (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LL/MavRrrc (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LN/MavRrrc (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

M520/N (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

MHS/Gib (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

MNS/Gib (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

MR/N (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

SBH/Ygl (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	SBH/Ygl sequenced by MCW

SBH/Ygl (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SBN/Ygl (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	SBN/Ygl sequenced by MCW

SBN/Ygl (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SHR/NHsd (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SHRSP/Gcrc (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SR/JrHsd (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Harlan Laboratories
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

SR/JrHsd (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SS/Jr (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SS/JrHsdMcwi (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

SS/JrHsdMcwi (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

WAG/Rij (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

WKY/Gcrc (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

WKY/N (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

WKY/NCrl (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

WKY/NHsd (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

WN/N (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:621731	AgrOrtholog
Ensembl Genes	ENSRNOG00000057078	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein	ENSRNOP00000073198	ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000085026	ENTREZGENE, UniProtKB/TrEMBL
Gene3D-CATH	1.10.490.100	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE	IMAGE:5623446	IMAGE-MGC_LOAD
InterPro	RTP801-like	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	RTP801-like_C_sf	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report	rno:140942	UniProtKB/Swiss-Prot
MGC_CLONE	MGC:72327	IMAGE-MGC_LOAD
NCBI Gene	140942	ENTREZGENE
PANTHER	PTHR12478	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam	RTP801_C	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen	Ddit4	PhenoGen
UniProt	DDIT4_RAT	UniProtKB/Swiss-Prot
	G3V620_RAT	UniProtKB/TrEMBL
	Q8VHZ9	ENTREZGENE

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2004-09-10	Ddit4	DNA-damage-inducible transcript 4	Rtp801	HIF-1 responsive RTP801	Symbol and Name updated	1299863	APPROVED
2002-08-07	Rtp801	HIF-1 responsive RTP801			Symbol and Name status set to provisional	70820	PROVISIONAL

RGD Curation Notes

Note Type	Note	Reference
gene_regulation	expression is up regulation by hypoxia	633979

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - CTD

Imported Annotations - KEGG (archival)

Imported Annotations - PID (archival)

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Imported Disease Annotations - CTD

Imported Annotations - KEGG (archival)

Imported Annotations - PID (archival)