C2 (complement C2) - Rat Genome Database

Name: C2
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

Gene: C2 (complement C2) Rattus norvegicus

Analyze

Symbol:

C2 (Ensembl: Cfb)

Name:

complement C2 (Ensembl:complement factor B)

RGD ID:

2231

Description:

Predicted to enable serine-type endopeptidase activity. Involved in response to nutrient. Human ortholog(s) of this gene implicated in Alzheimer's disease; age related macular degeneration 14; complement component 2 deficiency; macular degeneration; and psoriasis. Orthologous to human C2 (complement C2); PARTICIPATES IN coagulation cascade pathway; complement system pathway; Staphylococcus aureus infection pathway; INTERACTS WITH 1,3-dinitrobenzene; 17alpha-ethynylestradiol; 17beta-estradiol.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

complement component 2

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	C2 (complement C2)	RGD	RGD
Mus musculus (house mouse):	C2 (complement C2)	RGD	RGD
Chinchilla lanigera (long-tailed chinchilla):	C2 (complement C2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	C2 (complement C2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	C2 (complement C2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	C2 (complement C2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	C2 (complement C2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	C2 (complement C2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	C2 (complement C2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Other homologs ²
Homo sapiens (human):	CFB (complement factor B)	HGNC	EggNOG, Inparanoid
Alliance orthologs ³
Mus musculus (house mouse):	C2 (complement C2)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Homo sapiens (human):	C2 (complement C2)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	si:ch1073-280e3.1	Alliance	DIOPT (Ensembl Compara\|OMA\|OrthoFinder\|PANTHER)
Danio rerio (zebrafish):	bfb (complement component bfb)	Alliance	DIOPT (InParanoid\|OrthoInspector\|SonicParanoid)
Danio rerio (zebrafish):	cfb (complement factor B)	Alliance	DIOPT (InParanoid\|OrthoInspector\|SonicParanoid)
Danio rerio (zebrafish):	cfbl	Alliance	DIOPT (InParanoid\|OrthoInspector\|SonicParanoid)

Candidate Gene For:

Pur27 Pur30

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	20	3,944,722 - 3,975,006 (+)	NCBI		GRCr8
mRatBN7.2	20	3,951,474 - 3,970,376 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	20	3,951,474 - 3,976,505 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	20	4,651,385 - 4,670,381 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	20	4,013,128 - 4,032,129 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	20	4,550,327 - 4,569,295 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	20	4,542,340 - 4,561,152 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	20	4,542,340 - 4,561,152 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	20	6,622,139 - 6,641,139 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	20	4,051,146 - 4,071,909 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	20	4,051,372 - 4,072,135 (+)	NCBI
Celera	20	4,060,318 - 4,078,802 (-)	NCBI		Celera
Cytogenetic Map	20	p12	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Alzheimer's disease (ISO)

anterior uveitis (ISO)

atypical hemolytic-uremic syndrome (ISO)

Chronic Hepatitis B (IAGP)

complement component 2 deficiency (ISO)

Complement Factor B Deficiency (ISO)

COVID-19 (ISO)

dermatomyositis (ISO)

focal segmental glomerulosclerosis (ISO)

focal segmental glomerulosclerosis 1 (ISO)

IgA glomerulonephritis (ISO)

irritant dermatitis (ISO)

kidney disease (ISO)

macular degeneration (ISO)

otitis media (ISO)

Polypoidal Choroidal Vasculopathy (ISO)

proteasome-associated autoinflammatory syndrome 1 (ISO)

psoriasis (ISO)

systemic lupus erythematosus (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(1->4)-beta-D-glucan (ISO)

1,1-dichloroethene (ISO)

1,2-dimethylhydrazine (ISO)

1,3-dinitrobenzene (EXP)

17alpha-ethynylestradiol (EXP)

17beta-estradiol (EXP,ISO)

17beta-estradiol 3-benzoate (EXP)

2,2',4,4'-Tetrabromodiphenyl ether (EXP)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

3,3',5,5'-tetrabromobisphenol A (EXP)

4,4'-diaminodiphenylmethane (ISO)

4-hydroxyphenyl retinamide (ISO)

acrylamide (ISO)

aflatoxin B1 (ISO)

Aflatoxin B2 alpha (ISO)

alpha-Zearalanol (EXP)

antirheumatic drug (ISO)

aripiprazole (ISO)

aristolochic acid A (ISO)

benzene (ISO)

benzo[a]pyrene (ISO)

benzo[e]pyrene (ISO)

Benzo[ghi]perylene (ISO)

bisphenol A (EXP,ISO)

butanal (ISO)

C60 fullerene (EXP)

cadmium dichloride (EXP)

calcitriol (ISO)

carbon nanotube (ISO)

chlorpyrifos (ISO)

chromium(6+) (ISO)

clobetasol (ISO)

clofibrate (ISO)

copper atom (EXP)

copper(0) (EXP)

Cuprizon (EXP)

cyclosporin A (EXP,ISO)

decabromodiphenyl ether (EXP)

dichloroacetic acid (ISO)

diclofenac (ISO)

diuron (EXP)

epoxiconazole (ISO)

fenthion (ISO)

flutamide (EXP)

fulvestrant (ISO)

gentamycin (EXP)

glyphosate (ISO)

Indeno[1,2,3-cd]pyrene (ISO)

irinotecan (EXP)

ketamine (EXP)

lead diacetate (ISO)

methapyrilene (ISO)

methidathion (ISO)

methylphenidate (ISO)

mono(2-ethylhexyl) phthalate (ISO)

nefazodone (EXP)

nickel atom (ISO)

oxaliplatin (EXP)

ozone (ISO)

paracetamol (EXP,ISO)

paraquat (EXP)

perfluorohexanesulfonic acid (ISO)

perfluorooctane-1-sulfonic acid (ISO)

perfluorooctanoic acid (EXP,ISO)

phenytoin (EXP)

pirinixic acid (ISO)

potassium chromate (ISO)

progesterone (ISO)

propanal (ISO)

silicon dioxide (EXP,ISO)

sodium arsenite (ISO)

sodium dodecyl sulfate (ISO)

Soman (EXP)

tacrolimus hydrate (EXP)

testosterone (EXP)

tetrachloromethane (ISO)

tetraphene (ISO)

titanium dioxide (ISO)

topotecan (EXP)

Tributyltin oxide (ISO)

trimellitic anhydride (ISO)

triptonide (ISO)

valproic acid (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

complement activation (IBA,ISO)

complement activation, classical pathway (IEA)

positive regulation of apoptotic cell clearance (ISO)

proteolysis (IEA)

response to bacterium (IBA)

response to nutrient (IEP)

Molecular Function

protein binding (IPI,ISO)

serine-type endopeptidase activity (IEA)

Molecular Pathway Annotations Click to see Annotation Detail View

coagulation cascade pathway (IEA)

complement system pathway (IEA)

Staphylococcus aureus infection pathway (IEA)

systemic lupus erythematosus pathway (IEA)

References

References - curated

#	Reference Title	Reference Citation
1.	Susceptibility to advanced age-related macular degeneration and alleles of complement factor H, complement factor B, complement component 2, complement component 3, and age-related maculopathy susceptibility 2 genes in a Mexican population.	Buentello-Volante B, etal., Mol Vis. 2012;18:2518-25. Epub 2012 Oct 11.
2.	Two mechanisms for mannose-binding protein modulation of the activity of its associated serine proteases.	Chen CB and Wallis R, J Biol Chem. 2004 Jun 18;279(25):26058-65. Epub 2004 Apr 1.
3.	HLA-linked complement polymorphisms (C2, BF) in psoriasis.	Dewald G, etal., Arch Dermatol Res. 1983;275(5):301-4.
4.	Variations in five genes and the severity of age-related macular degeneration: results from the Muenster aging and retina study.	Farwick A, etal., Eye (Lond). 2009 Dec;23(12):2238-44. doi: 10.1038/eye.2008.426. Epub .
5.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
6.	Variation in factor B (BF) and complement component 2 (C2) genes is associated with age-related macular degeneration.	Gold B, etal., Nat Genet. 2006 Apr;38(4):458-62. Epub 2006 Mar 5.
7.	Association of polymorphisms in C2, CFB and C3 with exudative age-related macular degeneration in a Korean population.	Kim SJ, etal., Exp Eye Res. 2012 Mar;96(1):42-7. doi: 10.1016/j.exer.2012.01.005. Epub 2012 Jan 18.
8.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
9.	Significance of C2/CFB variants in age-related macular degeneration and polypoidal choroidal vasculopathy in a Japanese population.	Nakata I, etal., Invest Ophthalmol Vis Sci. 2012 Feb 16;53(2):794-8. doi: 10.1167/iovs.11-8468.
10.	OMIM Disease Annotation Pipeline	OMIM Disease Annotation Pipeline
11.	Protein Malnutrition and complement activity in guinea pigs, germ-free and conventional rats.	Petersen BH, etal., J Nutr. 1980 Nov;110(11):2159-65.
12.	KEGG Annotation Import Pipeline	Pipeline to import KEGG annotations from KEGG into RGD
13.	Alzheimer's disease and age-related macular degeneration have different genetic models for complement gene variation.	Proitsi P, etal., Neurobiol Aging. 2012 Aug;33(8):1843.e9-17. doi: 10.1016/j.neurobiolaging.2011.12.036. Epub 2012 Feb 1.
14.	GOA pipeline	RGD automated data pipeline
15.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
16.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
17.	Comprehensive gene review and curation	RGD comprehensive gene curation
18.	Analysis of rare variants in the complement component 2 (C2) and factor B (BF) genes refine association for age-related macular degeneration (AMD).	Richardson AJ, etal., Invest Ophthalmol Vis Sci. 2009 Feb;50(2):540-3. doi: 10.1167/iovs.08-2423. Epub 2008 Sep 20.
19.	Breakdown product of factor B as an index of complement activation in lepromatous leprosy and its relation with bacillary load.	Saha K, etal., Scand J Immunol. 1983 Jan;17(1):37-43.
20.	Protective effect of complement factor B and complement component 2 variants in age-related macular degeneration.	Spencer KL, etal., Hum Mol Genet. 2007 Aug 15;16(16):1986-92. Epub 2007 Jun 18.
21.	Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.	Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
22.	Enhanced susceptibility to acute pneumococcal otitis media in mice deficient in complement C1qa, factor B, and factor B/C2.	Tong HH, etal., Infect Immun. 2010 Mar;78(3):976-83. doi: 10.1128/IAI.01012-09. Epub 2010 Jan 11.
23.	Determination of the second component of complement (C2) by electroimmunoassay in sera from patients with systemic lupus erythematosus.	Ueda A, etal., Clin Exp Immunol. 1983 Jul;53(1):217-24.
24.	Physical mapping of the major histocompatibility complex class II and class III regions of the rat.	Walter L, etal., Immunogenetics 2002 Jul;54(4):268-75. Epub 2002 Jun 14.
25.	Association between polymorphisms of complement pathway genes and age-related macular degeneration in a Chinese population.	Wu L, etal., Invest Ophthalmol Vis Sci. 2013 Jan 7;54(1):170-4. doi: 10.1167/iovs.12-10453.
26.	Association of C2 and CFB polymorphisms with anterior uveitis.	Yang MM, etal., Invest Ophthalmol Vis Sci. 2012 Jul 27;53(8):4969-74. doi: 10.1167/iovs.12-9478.
27.	Rare inborn errors associated with chronic hepatitis B virus infection.	Zhao Q, etal., Hepatology. 2012 Nov;56(5):1661-70. doi: 10.1002/hep.25850. Epub 2012 Oct 14.

Additional References at PubMed

PMID:9688553	PMID:17204478	PMID:19302245	PMID:23533145	PMID:24006456

Genomics

Comparative Map Data

C2
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	20	3,944,722 - 3,975,006 (+)	NCBI		GRCr8
mRatBN7.2	20	3,951,474 - 3,970,376 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	20	3,951,474 - 3,976,505 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	20	4,651,385 - 4,670,381 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	20	4,013,128 - 4,032,129 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	20	4,550,327 - 4,569,295 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	20	4,542,340 - 4,561,152 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	20	4,542,340 - 4,561,152 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	20	6,622,139 - 6,641,139 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	20	4,051,146 - 4,071,909 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	20	4,051,372 - 4,072,135 (+)	NCBI
Celera	20	4,060,318 - 4,078,802 (-)	NCBI		Celera
Cytogenetic Map	20	p12	NCBI

C2
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	6	31,897,783 - 31,945,672 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	6	31,897,785 - 31,945,673 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	6	31,865,560 - 31,913,449 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	6	32,003,473 - 32,021,427 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	6	32,003,472 - 32,021,427	NCBI
Celera	6	33,495,068 - 33,513,211 (+)	NCBI		Celera
Cytogenetic Map	6	p21.33	NCBI
HuRef	6	31,651,618 - 31,700,418 (+)	NCBI		HuRef
CHM1_1	6	31,867,703 - 31,915,530 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	6	31,751,025 - 31,798,877 (+)	NCBI		T2T-CHM13v2.0

C2
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	17	35,081,578 - 35,101,076 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	17	35,081,580 - 35,117,241 (-)	Ensembl		GRCm39 Ensembl
GRCm38	17	34,862,602 - 34,882,100 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	17	34,862,604 - 34,898,265 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	17	34,999,547 - 35,019,045 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	17	34,470,663 - 34,490,103 (-)	NCBI		MGSCv36	mm8
Celera	17	37,957,910 - 37,977,407 (-)	NCBI		Celera
Cytogenetic Map	17	B1	NCBI
cM Map	17	18.41	NCBI

C2
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955437	448,672 - 460,519 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955437	449,171 - 460,898 (+)	NCBI	ChiLan1.0	ChiLan1.0

C2
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	5	46,376,853 - 46,422,221 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	6	42,367,483 - 42,383,704 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	6	31,590,135 - 31,606,368 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	6	32,476,791 - 32,492,982 (+)	NCBI	panpan1.1	PanPan1.1	panPan2

C2
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	12	1,363,656 - 1,399,732 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	12	1,363,803 - 1,399,728 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	12	1,493,696 - 1,534,930 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	12	1,500,603 - 1,542,031 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	12	1,500,627 - 1,542,028 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	12	1,358,291 - 1,399,309 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	12	1,426,238 - 1,467,677 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	12	1,491,715 - 1,533,005 (+)	NCBI		UU_Cfam_GSD_1.0

C2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404946	35,913,518 - 35,958,946 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936727	1,602,398 - 1,616,060 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936727	1,602,400 - 1,615,974 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

C2
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	7	23,995,982 - 24,033,930 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	7	24,020,590 - 24,034,042 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	7	27,778,160 - 27,791,919 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

C2
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	17	40,069,852 - 40,094,478 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	17	40,069,909 - 40,094,207 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666044	31,844,362 - 31,862,408 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

C2
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624754	24,317,058 - 24,322,656 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624754	24,316,778 - 24,327,065 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in C2
155 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	219
Count of miRNA genes:	132
Interacting mature miRNAs:	150
Transcripts:	ENSRNOT00000000477, ENSRNOT00000060607, ENSRNOT00000065044
Prediction methods:	Microtar, Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
61472	Aia1	Adjuvant induced arthritis QTL 1	18	0.001	joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	20	2646395	4597031	Rat
2306850	Pia40	Pristane induced arthritis QTL 40		0.0001	joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	20	1527959	5304575	Rat
1641915	Colcr9	Colorectal carcinoma resistance QTL 9	2.97	0.0024	intestine integrity trait (VT:0010554)	benign colorectal tumor number (CMO:0001795)	20	1530655	46530655	Rat
2317057	Aia27	Adjuvant induced arthritis QTL 27	2.83		joint integrity trait (VT:0010548)	right rear ankle joint diameter (CMO:0002150)	20	2892597	26381954	Rat
7411668	Foco32	Food consumption QTL 32	8	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	20	1	36600972	Rat
2305926	Iddm37	Insulin dependent diabetes mellitus QTL 37	6		blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	20	1527842	46527842	Rat
1354642	Despr15	Despair related QTL 15		0.0027	locomotor behavior trait (VT:0001392)	amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)	20	1	24159021	Rat
1600382	Edcs3	Endometrial carcinoma susceptibility QTL3	3.5	0.003	uterus morphology trait (VT:0001120)	percentage of study population developing endometrioid carcinoma during a period of time (CMO:0001759)	20	1	25159026	Rat
61448	Ciaa1	CIA Autoantibody QTL 1	30	0.001	blood autoantibody amount (VT:0003725)	calculated serum anti-rat type 2 collagen autoantibody titer (CMO:0001281)	20	2646395	4597031	Rat
1331772	Cdexp2	CD45RC expression in CD8 T cells QTL 2	5.7		CD8-positive T cell quantity (VT:0008077)	blood CD45RC(high) CD8 T cell count to CD45RC(low) CD8 T cell count ratio (CMO:0001990)	20	3621649	10078919	Rat
8694189	Bw153	Body weight QTL 153	3.13	0.001	body mass (VT:0001259)	body weight gain (CMO:0000420)	20	1	29191651	Rat
1300152	Bp195	Blood pressure QTL 195	3.46		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	20	3621649	9243559	Rat
9590109	Sffal8	Serum free fatty acids level QTL 8	5.32	0.01	blood free fatty acid amount (VT:0001553)	plasma free fatty acids level (CMO:0000546)	20	1	29191651	Rat
9590275	Scort15	Serum corticosterone level QTL 15	3.48	0.001	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	20	1	29191651	Rat
9589155	Insul32	Insulin level QTL 32	6.38	0.001	blood insulin amount (VT:0001560)	plasma insulin level (CMO:0000342)	20	1	29191651	Rat
7411650	Foco23	Food consumption QTL 23	20.7	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	20	1	29191651	Rat
2317851	Alcrsp22	Alcohol response QTL 22	3.2	0.05	response to alcohol trait (VT:0010489)	duration of loss of righting reflex (CMO:0002289)	20	1	27339237	Rat
1598816	Memor12	Memory QTL 12	2.4		exploratory behavior trait (VT:0010471)	average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)	20	2606836	47606836	Rat
61432	Cia1	Collagen induced arthritis QTL 1			joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	20	3621656	14101050	Rat
1641893	Alcrsp7	Alcohol response QTL 7			response to alcohol trait (VT:0010489)	duration of loss of righting reflex (CMO:0002289)	20	1	27339237	Rat
6893685	Bw111	Body weight QTL 111	2.7	0.004	body mass (VT:0001259)	body weight (CMO:0000012)	20	1	32578807	Rat
9590252	Scort12	Serum corticosterone level QTL 12	20.46	0.001	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	20	1	36600972	Rat
737973	Pia21	Pristane induced arthritis QTL 21	4.8		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	20	3621656	4606812	Rat

Markers in Region

D20Yum57

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	20	3,965,881 - 3,966,060 (-)	MAPPER	mRatBN7.2
Rnor_6.0	20	4,546,656 - 4,546,834	NCBI	Rnor6.0
Rnor_5.0	20	6,626,455 - 6,626,633	UniSTS	Rnor5.0
RGSC_v3.4	20	4,067,037 - 4,067,215	UniSTS	RGSC3.4
Celera	20	4,064,634 - 4,064,812	UniSTS
Cytogenetic Map	20	p12	UniSTS

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium	1	1	50	37	17	37					10	11
Low	2	42	7	4	2	4	8	11	72	35	31		8
Below cutoff									2

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001428631	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	NM_172222	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063278949	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AY149994	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC070923	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BX883045	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH474121	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000020	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000000477 ⟹ ENSRNOP00000000477

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	20	3,970,643 - 3,976,505 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000060607 ⟹ ENSRNOP00000057340

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	20	3,951,474 - 3,970,375 (+)	Ensembl
Rnor_6.0 Ensembl	20	4,542,340 - 4,561,152 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000065044 ⟹ ENSRNOP00000059051

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	20	3,951,474 - 3,970,375 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000075928 ⟹ ENSRNOP00000068499

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	20	3,951,564 - 3,970,375 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000092698 ⟹ ENSRNOP00000075765

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	20	3,951,474 - 3,970,375 (+)	Ensembl

RefSeq Acc Id:

NM_172222 ⟹ NP_757376

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	20	3,956,105 - 3,975,004 (+)	NCBI
mRatBN7.2	20	3,951,474 - 3,970,376 (+)	NCBI
Rnor_6.0	20	4,542,340 - 4,561,152 (-)	NCBI
Rnor_5.0	20	6,622,139 - 6,641,139 (-)	NCBI
RGSC_v3.4	20	4,051,146 - 4,071,909 (+)	RGD
Celera	20	4,060,318 - 4,078,802 (-)	RGD

Sequence:

show sequence

CAGCGGAGCCTACTCAACCCGCAGTGATTTCGGGGAAGTCAGATGACCTTTTCTCTCCCCTGGC
TCTCCCGTTCTACTGTTCTGGAAACCATGGCCCCTCTGCTGGCTCTCCTCGCCCTGCTGCAGCT
GGGCCCAGGCCTGGCTGCTCTTTCCTGCCCTCAGAATGTCAATATTGTCGGGGGGAATTTCACT
CTCAGCCGTGGCTGGGCTCCTGGGAGCGTCCTCATCTACTCCTGCCCCCTGGGCAGGTACCCGT
CCCCAGCCTGGCGGGAATGCCAGAGCAACGGGCAGTGGCAGACACCAAGAGCTAGCTCACTTCC
CACCCTGAGATCCTCTCGGTTGGCTAAAGCCGTCTGCAAACCTGTTCGATGTCCAGCTCCCACG
TCCTTTGAGAATGGCATCTATATCCCTCGGCTGGGGTCCTACCCCGTGGGTGGCAACCTGAGCT
TCGAGTGTGAGCATGGTTTCACCTTGCGGGGCTCGCCCGTGAGGTACTGTCGCCCCAACGGCGT
GTGGGATGGAGAGACGGCTGTGTGTGACAATGGCGCTAGCCACTGCCCCAACCCAGGCATCTCA
GTGGGCACAATGCGGACAGGCTCGAGCTTTGACCTTGGAGACAAGGTCAGTTACCGCTGTTCCT
CCACGAATCTGGTATTGACCGGCTCTGTAGAGCGGGAGTGTCTGAGTAACGGAGTGTGGAGTGG
GTCGGAGCCCATCTGCCGACAGCCATACTCTTACGACTTCCCTGAGGATGTAGCATCTGCCCTA
GGCACCTCCTTCACCCACCTGCTTGGAGCCACCAATCCCATCCAGAAGAGGACAGAAAACCTGG
GCCGTAAAATCCAAATCCAGCGCTCGGGCCACCTGAACCTCTATCTGCTGCTTGATGCCTCTCA
GAGCGTATCGGAAAAAGACTTTAACATCTTCAAGGAGAGCGCCTTCCTCATGGTGGACAGGATC
TTCAGCTTCGAGATAAAGGTCAGCGTAGCTATCATCACCTTCGCCTCACGGCCCAAAATCATCA
TGTCCGTCCTGAATGAGAGATCCCAGAATGTGATGGAGGTGATGGACAGTCTAGACTCTGTCTG
CTACAAAGATCACGAAAATGCCACTGGCACTAACACTTACGAGGCTCTCAACAGCGTCTACCTC
ATGATGAATAACCAGATGGATCGCCTCGGCATGGAGACCTCTGCCTGGCAGGAAATCCGCCATG
CCATCATCCTGTTGACTGACGGAAAGTCCAACATGGGTGGCTCTCCCAAGCCGGCAGTCGACAA
CATCAGAGAGATCCTGGGCATCAGTCGGAACAGAAACGACTACCTGGACATCTATGCGATTGGG
GTGGGTAAGCTGGATGTGGACTGGAAGGAACTGAACGAGCTGGGGTCCAAGAAGGACGGCGAGA
GGCACGCCTTCATCTTGCAGGACGCAAAAGCTGTGCAGCAGGTCTTTGAGCACATTCTGGATGT
CTCTAAGCTCACAGACACCATCTGTGGGGTGGGGAACATGTCCGTCAATGCCTCTGACCAGGAG
AGGACACCTTGGCAAGTCACCTTTAAGCCCAAGAGTAAGGAGACTTGCCAGGGGTCGCTTATCT
CTGACCAGTGGGTGCTGACTGCGGCTCACTGCTTCCATGACGCTCAGATGGAGGACCGCCACCT
GTGGAGGGTCATCGTGGGGGATCCCACCTCTCATCACGGCAAAGAATTCCATGTGGAGGAGGTG
TTAGTTGCCCCTGGGTTTAATGTCCACGCAAAGCAGAGCCAGGGCATCTCGGAGTTCTACGCTG
ATGACATTGCCCTGCTGAAGCTGTCTCAGAGAGTGAAAATGTCCAGCCACGCCAGGCCCATCTG
CCTTCCTTGCACAGTGGGGGCCAACATGGCTCTGCGGAGATCCCCAGGTAGTACCTGTAAAGAC
CATGAGACAGAACTTCTGTCACAGCAGAAGGTTCCTGCGCATTTCGTAGCTCTGAACGGGAACA
GAATGAACATCAACCTCAGGACAGGACCTGAGAGGACAAGCTGTATCGAGGCTGTCTCCCAAAA
CAAGGGCAGCTTCCCCGGCTTGACAAACGTCAGTGAGGTGGTGACAGACCAGTTCCTATGTAGC
GGGATGGAGGGAGATGACAGTCCTTGCAAAGGAGAATCCGGGGGAGCCGTTTTCCTTGAGCGGA
GGTACAGGTTTTTCCAGGTGGGCCTGGTGAGTTGGGGTCTTTTTGACCCTTGTCACGGTTCCTC
CAACAAAAACTTGCGCAGGAAGCCTCCGCATGGCGTTGTGCCTAGGGACTTCCACATCAGTCTC
TTCCGGCTGCAGCCCTGGTTGAGGCAGCACCTGGATGGTGTCCTCGACTTTTTGCCCCTTTAAC
ACGGTCACCGACTCCTTTGCTGGTCTGTCCCTCCTGTCTTCTGCCTCTGAGTGTTCTTGCTCCC
AGGTACATAAATCCTGGAACGCAGAGACAAAAGCTAGGAATCCCCAGGGTTGTGCCAGAACCAC
TGTGCCCTCCCGAGAAGCAAGTGTCTCTCTAGTGTGGATGACCCGTGCTCCTTTTGCTTTCACA
CAGAATTTCCCAGTTATGAAATTAATAAAAATCAATGATTTCCAAAAAAAAAAAAAAAAAAAAA
AAAAA

hide sequence

RefSeq Acc Id:

XM_063278949 ⟹ XP_063135019

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	20	3,944,722 - 3,975,006 (+)	NCBI

Protein Sequences


Protein RefSeqs	NP_001415560	(Get FASTA)	NCBI Sequence Viewer
	NP_757376	(Get FASTA)	NCBI Sequence Viewer
	XP_063135019	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAH70923	(Get FASTA)	NCBI Sequence Viewer
	AAN72414	(Get FASTA)	NCBI Sequence Viewer
	CAE83973	(Get FASTA)	NCBI Sequence Viewer
	EDL83453	(Get FASTA)	NCBI Sequence Viewer
	EDL83454	(Get FASTA)	NCBI Sequence Viewer
	EDL83455	(Get FASTA)	NCBI Sequence Viewer
	EDL83456	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000057340.4
	ENSRNOP00000059051.3
	ENSRNOP00000068499.2
	ENSRNOP00000075765.2

RefSeq Acc Id:	NP_757376 ⟸ NM_172222
- Peptide Label:	precursor
- UniProtKB:	Q6MG73 (UniProtKB/TrEMBL), D4AAK8 (UniProtKB/TrEMBL), Q8CIP8 (UniProtKB/TrEMBL)
- Sequence:	show sequence MAPLLALLALLQLGPGLAALSCPQNVNIVGGNFTLSRGWAPGSVLIYSCPLGRYPSPAWRECQS NGQWQTPRASSLPTLRSSRLAKAVCKPVRCPAPTSFENGIYIPRLGSYPVGGNLSFECEHGFTL RGSPVRYCRPNGVWDGETAVCDNGASHCPNPGISVGTMRTGSSFDLGDKVSYRCSSTNLVLTGS VERECLSNGVWSGSEPICRQPYSYDFPEDVASALGTSFTHLLGATNPIQKRTENLGRKIQIQRS GHLNLYLLLDASQSVSEKDFNIFKESAFLMVDRIFSFEIKVSVAIITFASRPKIIMSVLNERSQ NVMEVMDSLDSVCYKDHENATGTNTYEALNSVYLMMNNQMDRLGMETSAWQEIRHAIILLTDGK SNMGGSPKPAVDNIREILGISRNRNDYLDIYAIGVGKLDVDWKELNELGSKKDGERHAFILQDA KAVQQVFEHILDVSKLTDTICGVGNMSVNASDQERTPWQVTFKPKSKETCQGSLISDQWVLTAA HCFHDAQMEDRHLWRVIVGDPTSHHGKEFHVEEVLVAPGFNVHAKQSQGISEFYADDIALLKLS QRVKMSSHARPICLPCTVGANMALRRSPGSTCKDHETELLSQQKVPAHFVALNGNRMNINLRTG PERTSCIEAVSQNKGSFPGLTNVSEVVTDQFLCSGMEGDDSPCKGESGGAVFLERRYRFFQVGL VSWGLFDPCHGSSNKNLRRKPPHGVVPRDFHISLFRLQPWLRQHLDGVLDFLPL hide sequence

Ensembl Acc Id:

ENSRNOP00000057340 ⟸ ENSRNOT00000060607

Ensembl Acc Id:

ENSRNOP00000059051 ⟸ ENSRNOT00000065044

Ensembl Acc Id:

ENSRNOP00000000477 ⟸ ENSRNOT00000000477

Ensembl Acc Id:

ENSRNOP00000068499 ⟸ ENSRNOT00000075928

Ensembl Acc Id:

ENSRNOP00000075765 ⟸ ENSRNOT00000092698

RefSeq Acc Id:	XP_063135019 ⟸ XM_063278949
- Peptide Label:	isoform X1

Protein Domains

Peptidase S1 Sushi VWFA

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q6MG73-F1-model_v2	AlphaFold	Q6MG73	1-758	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13701357

Promoter ID:

EPDNEW_R11880

Type:

initiation region

Name:

C2_1

Description:

complement C2

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	20	4,561,112 - 4,561,172	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:2231	AgrOrtholog
BioCyc Gene	G2FUF-4603	BioCyc
Ensembl Genes	ENSRNOG00000051235	Ensembl, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000060607.5	UniProtKB/TrEMBL
	ENSRNOT00000065044.5	UniProtKB/TrEMBL
	ENSRNOT00000075928.3	UniProtKB/TrEMBL
	ENSRNOT00000092698.2	UniProtKB/TrEMBL
Gene3D-CATH	2.40.10.10	UniProtKB/TrEMBL
	2.40.10.120	UniProtKB/TrEMBL
	3.40.50.410	UniProtKB/TrEMBL
	Complement Module, domain 1	UniProtKB/TrEMBL
IMAGE_CLONE	IMAGE:7096131	IMAGE-MGC_LOAD
InterPro	Compl_C2_B	UniProtKB/TrEMBL
	Peptidase_S1/S6_AS	UniProtKB/TrEMBL
	Peptidase_S1_PA_chymotrypsin	UniProtKB/TrEMBL
	Peptidase_S1_S6	UniProtKB/TrEMBL
	Peptidase_S1A	UniProtKB/TrEMBL
	Ser/Cys_Pept_Trypsin-like	UniProtKB/TrEMBL
	Sushi/SCR/CCP_sf	UniProtKB/TrEMBL
	Sushi_SCR_CCP	UniProtKB/TrEMBL
	TRYPSIN_SER	UniProtKB/TrEMBL
	VWF_A	UniProtKB/TrEMBL
	vWFA_dom_sf	UniProtKB/TrEMBL
KEGG Report	rno:24231	UniProtKB/TrEMBL
MGC_CLONE	MGC:91431	IMAGE-MGC_LOAD
NCBI Gene	24231	ENTREZGENE
PANTHER	PTHR46393	UniProtKB/TrEMBL
	PTHR46393:SF2	UniProtKB/TrEMBL
Pfam	Sushi	UniProtKB/TrEMBL
	Trypsin	UniProtKB/TrEMBL
	VWA	UniProtKB/TrEMBL
PhenoGen	C2	PhenoGen
PIRSF	Compl_C2_B	UniProtKB/TrEMBL
PRINTS	CHYMOTRYPSIN	UniProtKB/TrEMBL
PROSITE	SUSHI	UniProtKB/TrEMBL
	TRYPSIN_DOM	UniProtKB/TrEMBL
	TRYPSIN_HIS	UniProtKB/TrEMBL
	TRYPSIN_SER	UniProtKB/TrEMBL
	VWFA	UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000051235	RatGTEx
SMART	CCP	UniProtKB/TrEMBL
	Tryp_SPc	UniProtKB/TrEMBL
	VWA	UniProtKB/TrEMBL
Superfamily-SCOP	Complement_control_module	UniProtKB/TrEMBL
	Pept_Ser_Cys	UniProtKB/TrEMBL
	SSF53300	UniProtKB/TrEMBL
UniProt	A0A096MKF9_RAT	UniProtKB/TrEMBL
	A0A0U1RRP9_RAT	UniProtKB/TrEMBL
	A0A8J8XKZ6_RAT	UniProtKB/TrEMBL
	A0A8J8YKQ8_RAT	UniProtKB/TrEMBL
	A6KTM3_RAT	UniProtKB/TrEMBL
	A6KTM4_RAT	UniProtKB/TrEMBL
	A6KTM5_RAT	UniProtKB/TrEMBL
	A6KTM6_RAT	UniProtKB/TrEMBL
	D4AAK8	ENTREZGENE
	Q6MG73	ENTREZGENE, UniProtKB/TrEMBL
	Q8CIP8	ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary	D4AAK8	UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2016-08-24	C2	complement C2	C2	complement component 2	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2002-06-10	C2	Complement component 2			Symbol and Name status set to approved	70586	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

Imported Annotations - KEGG (archival)

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

Imported Annotations - KEGG (archival)