Gene: C2 (complement C2) Rattus norvegicus
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Symbol:
C2
Name:
complement C2
Description:
Predicted to have serine-type endopeptidase activity. Involved in response to nutrient. Predicted to localize to the extracellular region. Human ortholog(s) of this gene implicated in Alzheimer's disease; age related macular degeneration 14; complement component 2 deficiency; macular degeneration; and psoriasis. Orthologous to human C2 (complement C2); PARTICIPATES IN coagulation cascade pathway; complement system pathway; Staphylococcus aureus infection pathway; INTERACTS WITH 1,3-dinitrobenzene; 17alpha-ethynylestradiol; 2,2',4,4'-Tetrabromodiphenyl ether.
Type:
protein-coding
RefSeq Status:
VALIDATED
Also known as:
complement component 2
Orthologs:
Latest Assembly:
Rnor_6.0 - RGSC Genome Assembly v6.0
NCBI Annotation Information:
Annotation category: suggests misassembly
Position:
Rat Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl Rnor_6.0 20 4,542,340 - 4,561,152 (-) NCBI Rnor6.0 Rnor_6.0 rn6 Rnor6.0 Rnor_6.0 Ensembl 20 4,542,340 - 4,561,152 (-) Ensembl Rnor_5.0 20 6,622,139 - 6,641,139 (-) NCBI Rnor5.0 Rnor_5.0 rn5 Rnor5.0 RGSC_v3.4 20 4,051,146 - 4,071,909 (+) NCBI RGSC3.4 rn4 RGSC3.4 RGSC_v3.1 20 4,051,372 - 4,072,135 (+) NCBI Celera 20 4,060,318 - 4,078,802 (-) NCBI Celera Cytogenetic Map 20 p12 NCBI
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Model
Disease Annotations
RGD Manual Annotations
Alzheimer's disease ISO RGD:1353499 7401250 DNA:SNP, haplotype: :p.E318D (rs9332739) (human) RGD anterior uveitis no_association ISO RGD:1353499 7411695 DNA:SNP: :rs3020644 (human) RGD macular degeneration susceptibility ISO RGD:1353499 1600582 DNA:polymorphism RGD macular degeneration no_association ISO RGD:1353499 7411731 DNA:missense mutation, snp:cds, intron:p.E318D, c.1360+62G>T (rs9332739, rs547154) (human) RGD macular degeneration ISO RGD:1353499 7411692 DNA:missense mutation, SNP:cds, intron:p.E318D, c.1360+62G>T (rs9332739, rs547154) (human) RGD macular degeneration susceptibility ISO RGD:1353499 7411713 DNA:SNP, haplotype:intron:c.1360+62G>T (rs547154) (human) RGD macular degeneration no_association ISO RGD:1353499 7411693 ; 7411691 DNA:missense mutation:cds:p.E318D (rs9332739) (human) RGD macular degeneration susceptibility ISO RGD:1353499 7411694 DNA:SNP:intron:c.1360+62G>T (rs547154) (human) RGD macular degeneration susceptibility ISO RGD:1353499 7411720 DNA:missense mutation, haplotype:cds:p.E318D (rs9332739) (human) RGD otitis media ISO RGD:10255 7411716 associated with Pneumococcal Infections RGD Polypoidal Choroidal Vasculopathy susceptibility ISO RGD:1353499 7411694 DNA:SNP:intron:c.1360+62G>T (rs547154) (human) RGD psoriasis ISO RGD:1353499 7411727 DNA:polymorphism: :C2*2 (human) RGD systemic lupus erythematosus ISO RGD:1353499 7421516 RGD
Imported Annotations - ClinVar
age related macular degeneration 14 ISO RGD:1353499 8554872 ClinVar Annotator: match by OMIM:615489 ClinVar PMID:16518403 , PMID:16936732 age related macular degeneration 14 ISO RGD:1353499 8554872 ClinVar Annotator: match by term: Age-related macular degeneration 14 ClinVar PMID:16518403 more ... age related macular degeneration 14 ISO RGD:1353499 8554872 ClinVar Annotator: match by term: Age-related macular degeneration 14 ClinVar PMID:16518403 more ... age related macular degeneration 14 ISO RGD:1353499 8554872 ClinVar Annotator: match by term: Age-related macular degeneration 14 ClinVar PMID:16518403 more ... atypical hemolytic-uremic syndrome ISO RGD:1353499 8554872 ClinVar Annotator: match by term: Atypical hemolytic uremic syndrome ClinVar PMID:20108004 more ... atypical hemolytic-uremic syndrome ISO RGD:1353499 8554872 ClinVar Annotator: match by term: Atypical hemolytic uremic syndrome ClinVar PMID:16518403 more ... atypical hemolytic-uremic syndrome ISO RGD:1353499 8554872 ClinVar Annotator: match by term: Atypical hemolytic uremic syndrome ClinVar PMID:21541267 atypical hemolytic-uremic syndrome ISO RGD:1353499 8554872 ClinVar Annotator: match by term: Atypical hemolytic uremic syndrome ClinVar atypical hemolytic-uremic syndrome ISO RGD:1353499 8554872 ClinVar Annotator: match by term: Atypical hemolytic uremic syndrome ClinVar PMID:16518403 more ... complement component 2 deficiency ISO RGD:1353499 8554872 ClinVar Annotator: match by term: Complement component 2 deficiency ClinVar PMID:25741868 complement component 2 deficiency ISO RGD:1353499 8554872 ClinVar Annotator: match by term: C2 deficiency, type II ClinVar PMID:8621452 complement component 2 deficiency ISO RGD:1353499 8554872 ClinVar Annotator: match by term: Complement component 2 deficiency ClinVar PMID:24033266 complement component 2 deficiency ISO RGD:1353499 8554872 ClinVar Annotator: match by term: Complement component 2 deficiency ClinVar PMID:16518403 more ... complement component 2 deficiency ISO RGD:1353499 8554872 ClinVar Annotator: match by term: Complement component 2 deficiency ClinVar PMID:16518403 more ... complement component 2 deficiency ISO RGD:1353499 8554872 ClinVar Annotator: match by term: C2 deficiency ClinVar PMID:21541267 complement component 2 deficiency ISO RGD:1353499 8554872 ClinVar Annotator: match by term: Complement component 2 deficiency ClinVar complement component 2 deficiency ISO RGD:1353499 8554872 ClinVar Annotator: match by term: C2 deficiency ClinVar PMID:16518403 more ... complement component 2 deficiency ISO RGD:1353499 8554872 ClinVar Annotator: match by term: C2 deficiency, type I ClinVar PMID:1577763 complement component 2 deficiency ISO RGD:1353499 8554872 ClinVar Annotator: match by OMIM:217000 ClinVar PMID:1577763 , PMID:24033266 complement component 2 deficiency ISO RGD:1353499 8554872 ClinVar Annotator: match by term: Complement component 2 deficiency ClinVar PMID:20108004 more ... Complement Factor B Deficiency ISO RGD:1353499 8554872 ClinVar Annotator: match by term: Complement factor B deficiency ClinVar PMID:20108004 more ... macular degeneration ISO RGD:1353499 8554872 ClinVar Annotator: match by term: Macular degeneration ClinVar PMID:24033266 macular degeneration ISO RGD:1353499 8554872 ClinVar Annotator: match by term: Macular degeneration ClinVar PMID:16518403 more ... macular degeneration ISO RGD:1353499 8554872 ClinVar Annotator: match by term: Macular degeneration ClinVar PMID:16518403 more ... macular degeneration ISO RGD:1353499 8554872 ClinVar Annotator: match by term: Macular degeneration ClinVar PMID:21541267 macular degeneration ISO RGD:1353499 8554872 ClinVar Annotator: match by term: Macular degeneration ClinVar macular degeneration ISO RGD:1353499 8554872 ClinVar Annotator: match by term: Macular degeneration ClinVar PMID:16518403 more ... macular degeneration ISO RGD:1353499 8554872 ClinVar Annotator: match by term: Macular degeneration ClinVar PMID:20108004 more ...
Imported Annotations - CTD
dermatomyositis ISO RGD:1353499 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:3501473 IgA glomerulonephritis ISO RGD:1353499 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:25133636 irritant dermatitis ISO RGD:1353499 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:27258892 macular degeneration ISO RGD:1353499 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:16518403 Imported Annotations - OMIM
age related macular degeneration 14 ISO RGD:1353499 7240710 OMIM complement component 2 deficiency ISO RGD:1353499 7240710 OMIM
1,1-dichloroethene increases expression ISO RGD:10255 6480464 vinylidene chloride results in increased expression of C2 mRNA CTD PMID:26682919 1,3-dinitrobenzene decreases expression EXP 6480464 3-dinitrobenzene results in decreased expression of C2 protein CTD PMID:24140754 17alpha-ethynylestradiol increases expression EXP 6480464 Ethinyl Estradiol results in increased expression of C2 mRNA CTD PMID:16174780 , PMID:17557909 17beta-estradiol affects expression ISO RGD:10255 6480464 Estradiol affects the expression of C2 mRNA CTD PMID:15598610 17beta-estradiol multiple interactions ISO RGD:1353499 6480464 [Estradiol co-treated with Progesterone] results in decreased expression of C2 mRNA CTD PMID:20660070 2,2',4,4'-Tetrabromodiphenyl ether increases expression EXP 6480464 2 more ... CTD PMID:21394737 2,3,7,8-tetrachlorodibenzodioxine decreases expression EXP 6480464 Tetrachlorodibenzodioxin results in decreased expression of C2 mRNA CTD PMID:21215274 2,3,7,8-tetrachlorodibenzodioxine affects expression ISO RGD:10255 6480464 Tetrachlorodibenzodioxin affects the expression of C2 mRNA CTD PMID:21570461 2,3,7,8-tetrachlorodibenzodioxine increases expression ISO RGD:1353499 6480464 Tetrachlorodibenzodioxin results in increased expression of C2 mRNA CTD PMID:20106945 , PMID:21632981 3,3',5,5'-tetrabromobisphenol A decreases expression EXP 6480464 tetrabromobisphenol A results in decreased expression of C2 mRNA CTD PMID:28300664 4,4'-diaminodiphenylmethane increases expression ISO RGD:10255 6480464 4, 4'-diaminodiphenylmethane results in increased expression of C2 mRNA CTD PMID:18648102 4-hydroxyphenyl retinamide decreases expression ISO RGD:10255 6480464 Fenretinide results in decreased expression of C2 mRNA CTD PMID:28973697 aflatoxin B1 affects expression ISO RGD:1353499 6480464 Aflatoxin B1 affects the expression of C2 protein CTD PMID:20106945 aflatoxin B1 affects methylation ISO RGD:1353499 6480464 Aflatoxin B1 affects the methylation of C2 intron CTD PMID:30157460 aflatoxin B1 decreases expression ISO RGD:1353499 6480464 Aflatoxin B1 results in decreased expression of C2 mRNA CTD PMID:27153756 aflatoxin B2 decreases methylation ISO RGD:1353499 6480464 aflatoxin B2 results in decreased methylation of C2 intron CTD PMID:30157460 antirheumatic drug decreases expression ISO RGD:1353499 6480464 Antirheumatic Agents results in decreased expression of C2 mRNA CTD PMID:24449571 aripiprazole multiple interactions ISO RGD:1353499 6480464 [Aripiprazole co-treated with Ozone] results in increased expression of C2 mRNA CTD PMID:31476115 benzo[a]pyrene multiple interactions ISO RGD:10255 6480464 AHR protein affects the reaction [Benzo(a)pyrene affects the expression of C2 mRNA] CTD PMID:22228805 benzo[e]pyrene decreases methylation ISO RGD:1353499 6480464 benzo(e)pyrene results in decreased methylation of C2 intron CTD PMID:30157460 Benzo[ghi]perylene increases expression ISO RGD:10255 6480464 1, 12-benzoperylene results in increased expression of C2 mRNA CTD PMID:26377693 bisphenol A increases expression ISO RGD:10255 6480464 bisphenol A results in increased expression of C2 mRNA CTD PMID:26063408 bisphenol A increases expression ISO RGD:1353499 6480464 bisphenol A results in increased expression of C2 mRNA CTD PMID:27685785 bisphenol A increases expression EXP 6480464 bisphenol A results in increased expression of C2 mRNA CTD PMID:25181051 butanal increases expression ISO RGD:1353499 6480464 butyraldehyde results in increased expression of C2 mRNA CTD PMID:26079696 C60 fullerene increases expression EXP 6480464 fullerene C60 results in increased expression of C2 mRNA CTD PMID:19167457 cadmium dichloride decreases methylation EXP 6480464 Cadmium Chloride results in decreased methylation of C2 promoter CTD PMID:22457795 calcitriol decreases expression ISO RGD:1353499 6480464 Calcitriol results in decreased expression of C2 mRNA CTD PMID:26485663 carbon nanotube decreases expression ISO RGD:10255 6480464 Nanotubes, Carbon analog results in decreased expression of C2 mRNA CTD PMID:25554681 carbon nanotube affects expression ISO RGD:10255 6480464 Nanotubes, Carbon affects the expression of C2 mRNA CTD PMID:25554681 chromium(6+) affects expression ISO RGD:10255 6480464 chromium hexavalent ion affects the expression of C2 mRNA CTD PMID:28472532 chromium(6+) decreases expression ISO RGD:1353499 6480464 chromium hexavalent ion results in decreased expression of C2 mRNA CTD PMID:30690063 clobetasol increases expression ISO RGD:10255 6480464 Clobetasol results in increased expression of C2 mRNA CTD PMID:27462272 clofibrate multiple interactions ISO RGD:10255 6480464 [Clofibrate co-treated with Acetaminophen] affects the expression of C2 mRNA, PPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of C2 mRNA] CTD PMID:17585979 clofibrate decreases expression ISO RGD:10255 6480464 Clofibrate results in decreased expression of C2 mRNA CTD PMID:23811191 copper atom decreases expression EXP 6480464 Copper results in decreased expression of C2 mRNA CTD PMID:30556269 copper(0) decreases expression EXP 6480464 Copper results in decreased expression of C2 mRNA CTD PMID:30556269 cyclosporin A increases expression EXP 6480464 Cyclosporine results in increased expression of C2 mRNA CTD PMID:21865292 cyclosporin A decreases expression ISO RGD:1353499 6480464 Cyclosporine results in decreased expression of C2 mRNA CTD PMID:20106945 , PMID:25562108 decabromodiphenyl ether decreases expression EXP 6480464 decabromobiphenyl ether results in decreased expression of C2 mRNA CTD PMID:23914054 dichloroacetic acid decreases expression ISO RGD:10255 6480464 Dichloroacetic Acid results in decreased expression of C2 mRNA CTD PMID:28962523 diclofenac increases expression ISO RGD:10255 6480464 Diclofenac results in increased expression of C2 mRNA CTD PMID:26934552 diuron decreases expression EXP 6480464 Diuron results in decreased expression of C2 mRNA CTD PMID:21551480 , PMID:25152437 flutamide decreases expression EXP 6480464 Flutamide results in decreased expression of C2 mRNA CTD PMID:24136188 gentamycin increases expression EXP 6480464 Gentamicins results in increased expression of C2 mRNA CTD PMID:21081137 , PMID:22061828 glyphosate increases expression ISO RGD:1353499 6480464 glyphosate results in increased expression of C2 mRNA CTD PMID:17984146 Indeno[1,2,3-cd]pyrene decreases expression ISO RGD:10255 6480464 indeno(1 more ... CTD PMID:26377693 irinotecan affects expression EXP 6480464 Irinotecan affects the expression of C2 mRNA CTD PMID:20097248 ketamine increases expression EXP 6480464 Ketamine results in increased expression of C2 mRNA CTD PMID:20080153 lead diacetate increases expression ISO RGD:10255 6480464 lead acetate results in increased expression of C2 mRNA CTD PMID:22609695 methapyrilene decreases methylation ISO RGD:1353499 6480464 Methapyrilene results in decreased methylation of C2 intron CTD PMID:30157460 methylphenidate increases expression ISO RGD:10255 6480464 Methylphenidate results in increased expression of C2 mRNA CTD PMID:22470460 nefazodone decreases expression EXP 6480464 nefazodone results in decreased expression of C2 mRNA CTD PMID:24136188 nickel atom increases expression ISO RGD:1353499 6480464 Nickel results in increased expression of C2 mRNA CTD PMID:23195993 oxaliplatin multiple interactions EXP 6480464 [oxaliplatin co-treated with Topotecan] results in increased expression of C2 mRNA CTD PMID:25729387 ozone increases expression ISO RGD:1353499 6480464 Ozone results in increased expression of C2 mRNA CTD PMID:31476115 ozone multiple interactions ISO RGD:1353499 6480464 [Aripiprazole co-treated with Ozone] results in increased expression of C2 mRNA CTD PMID:31476115 paracetamol multiple interactions ISO RGD:10255 6480464 [Clofibrate co-treated with Acetaminophen] affects the expression of C2 mRNA more ... CTD PMID:17585979 , PMID:29246445 paracetamol decreases expression ISO RGD:1353499 6480464 Acetaminophen results in decreased expression of C2 mRNA CTD PMID:29067470 paracetamol decreases expression ISO RGD:10255 6480464 Acetaminophen results in decreased expression of C2 mRNA CTD PMID:29246445 paracetamol affects expression ISO RGD:10255 6480464 Acetaminophen affects the expression of C2 mRNA CTD PMID:17562736 perfluorooctane-1-sulfonic acid affects expression ISO RGD:10255 6480464 perfluorooctane sulfonic acid affects the expression of C2 mRNA CTD PMID:19429403 perfluorooctane-1-sulfonic acid decreases expression ISO RGD:10255 6480464 perfluorooctane sulfonic acid results in decreased expression of C2 mRNA CTD PMID:20936131 perfluorooctanoic acid affects expression ISO RGD:10255 6480464 perfluorooctanoic acid affects the expression of C2 mRNA CTD PMID:19429403 perfluorooctanoic acid decreases expression ISO RGD:10255 6480464 perfluorooctanoic acid results in decreased expression of C2 mRNA CTD PMID:18467677 , PMID:20936131 perfluorooctanoic acid multiple interactions ISO RGD:10255 6480464 PPARA protein promotes the reaction [perfluorooctanoic acid results in decreased expression of C2 mRNA] CTD PMID:18467677 phenytoin decreases expression EXP 6480464 Phenytoin results in decreased expression of C2 mRNA CTD PMID:20345932 pirinixic acid multiple interactions ISO RGD:10255 6480464 [pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of C2 mRNA, PPARA protein promotes the reaction [pirinixic acid results in decreased expression of C2 mRNA] CTD PMID:17950772 more ... pirinixic acid decreases expression ISO RGD:10255 6480464 pirinixic acid results in decreased expression of C2 mRNA CTD PMID:17426115 more ... potassium chromate decreases expression ISO RGD:1353499 6480464 potassium chromate(VI) results in decreased expression of C2 mRNA CTD PMID:22714537 progesterone multiple interactions ISO RGD:1353499 6480464 [Estradiol co-treated with Progesterone] results in decreased expression of C2 mRNA CTD PMID:20660070 propanal increases expression ISO RGD:1353499 6480464 propionaldehyde results in increased expression of C2 mRNA CTD PMID:26079696 silicon dioxide increases expression EXP 6480464 Silicon Dioxide results in increased expression of C2 mRNA CTD PMID:22431001 sodium arsenite increases expression ISO RGD:1353499 6480464 sodium arsenite results in increased expression of C2 mRNA CTD PMID:22714537 sodium dodecyl sulfate affects response to substance ISO RGD:1353499 6480464 C2 SNP affects the susceptibility to Sodium Dodecyl Sulfate CTD PMID:27258892 Soman increases expression EXP 6480464 Soman results in increased expression of C2 mRNA CTD PMID:19281266 tacrolimus hydrate increases expression EXP 6480464 Tacrolimus results in increased expression of C2 mRNA CTD PMID:21865292 tetrachloromethane decreases expression ISO RGD:10255 6480464 Carbon Tetrachloride results in decreased expression of C2 mRNA CTD PMID:27339419 tetraphene decreases expression ISO RGD:10255 6480464 benz(a)anthracene results in decreased expression of C2 mRNA CTD PMID:26377693 titanium dioxide affects expression ISO RGD:10255 6480464 titanium dioxide affects the expression of C2 mRNA CTD PMID:17656681 , PMID:23557971 topotecan multiple interactions EXP 6480464 [oxaliplatin co-treated with Topotecan] results in increased expression of C2 mRNA CTD PMID:25729387 Tributyltin oxide increases expression ISO RGD:10255 6480464 bis(tri-n-butyltin)oxide results in increased expression of C2 mRNA CTD PMID:18958704 trimellitic anhydride decreases expression ISO RGD:10255 6480464 trimellitic anhydride results in decreased expression of C2 mRNA CTD PMID:19042947 valproic acid decreases expression ISO RGD:1353499 6480464 Valproic Acid results in decreased expression of C2 mRNA CTD PMID:29154799
Gene-Chemical Interaction Annotations
