RGD Reference Report - HLA-linked complement polymorphisms (C2, BF) in psoriasis. - Rat Genome Database

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HLA-linked complement polymorphisms (C2, BF) in psoriasis.

Authors: Dewald, G  Lange, CE  Schmeel, E  Kreysel, HW 
Citation: Dewald G, etal., Arch Dermatol Res. 1983;275(5):301-4.
RGD ID: 7411727
Pubmed: PMID:6559061   (View Abstract at PubMed)

Starting from the known association between psoriasis and several HLA antigens and from the fact that the HLA chromosomal region contains the structural genes for at least three complement components, the authors have looked for an association between psoriasis and allotypes of C2 and BF. C2 and BF polymorphism were examined in 230 psoriatic patients. Two rare complement genes were found to be significantly increased when compared with controls: the frequency of the C2*2 gene was 0.061 among patients and 0.035 among controls (P less than 0.05); for BF*SO7, the frequencies were 0.0304 in patients and 0.0092 in controls (P less than 0.0005). The BF*F gene frequency, however, was significantly decreased among patients: 0.1196 vs. 0.1743 (P less than 0.01). The relative risks were 1.79 for the C2 2, 3.44 for the BF SO7, and 0.6 for the BF F gene product. From previous studies, it is known that these three complement alleles (C2*2, BF*SO7, BF*F) are in linkage disequilibrium with HLA alleles that have also been found increased or decreased, respectively, in psoriasis.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
C2Ratpsoriasis  ISOC2 (Homo sapiens)DNA:polymorphism: :C2*2 (human)RGD 
C2Humanpsoriasis  IAGP DNA:polymorphism: :C2*2 (human)RGD 
C2Mousepsoriasis  ISOC2 (Homo sapiens)DNA:polymorphism: :C2*2 (human)RGD 
CFBHumanpsoriasis  IAGP DNA:polymorphismsRGD 
CfbRatpsoriasis  ISOCFB (Homo sapiens)DNA:polymorphismsRGD 
CfbMousepsoriasis  ISOCFB (Homo sapiens)DNA:polymorphismsRGD 

Phenotype Annotations    Click to see Annotation Detail View

Manual Human Phenotype Annotations - RGD

Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
C2HumanPsoriasiform dermatitis  IAGP DNA:polymorphism: :C2*2RGD 
CFBHumanPsoriasiform dermatitis  IAGP DNA:polymorphismsRGD 
Objects Annotated

Genes (Rattus norvegicus)
C2  (complement C2)
Cfb  (complement factor B)

Genes (Mus musculus)
C2  (complement C2)
Cfb  (complement factor B)

Genes (Homo sapiens)
C2  (complement C2)
CFB  (complement factor B)


Additional Information