Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   
Gene: Cfb (complement factor B) Mus musculus
Symbol: Cfb
Name: complement factor B
RGD ID: 10236
Description: Predicted to have serine-type endopeptidase activity. Involved in complement activation, alternative pathway. Predicted to localize to extracellular space. Is expressed in embryo; liver lobe; metanephros; ovary; and testis. Human ortholog(s) of this gene implicated in several diseases, including acute lymphoblastic leukemia; atypical hemolytic-uremic syndrome; eye disease (multiple); glomerulonephritis (multiple); and sickle cell anemia. Orthologous to human CFB (complement factor B); PARTICIPATES IN coagulation cascade pathway; complement system pathway; Staphylococcus aureus infection pathway; INTERACTS WITH 1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane; 1,2-dimethylhydrazine; 17alpha-ethynylestradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: AI195813; AI255840; alternative-complement pathway C3/C5 convertase; B; Bf; C2; C3/C5 convertase; complement component 2 (within H-2S); Factor B; Fb; H2-Bf; histocompatibility 2, complement component factor B; properdin
Homo sapiens (human) : CFB (complement factor B)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Cfb (complement factor B)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Cfb (complement factor B)
Pan paniscus (bonobo/pygmy chimpanzee) : CFB (complement factor B)
Canis lupus familiaris (dog) : CFB (complement factor B)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Cfb (complement factor B)
Sus scrofa (pig) : CFB (complement factor B)
Heterocephalus glaber (naked mole-rat) : Cfb (complement factor B)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38.p6 Ensembl1734,856,374 - 34,862,518 (-)EnsemblGRCm38mm10GRCm38
GRCm381734,856,374 - 34,862,514 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv371734,993,319 - 34,999,459 (-)NCBIGRCm37mm9NCBIm37
MGSCv361734,464,437 - 34,470,273 (-)NCBImm8
Celera1737,951,682 - 37,957,822 (-)NCBICelera
Cytogenetic Map17B1NCBI
cM Map1718.41NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Cfb
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 10236
Created: 2000-05-25
Species: Mus musculus
Last Modified: 2020-09-23
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.