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Gene: Cfb (complement factor B) Mus musculus
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Symbol: Cfb
Name: complement factor B
RGD ID: 10236
Description: Predicted to have serine-type endopeptidase activity. Involved in complement activation, alternative pathway. Predicted to localize to extracellular space. Is expressed in embryo; liver lobe; metanephros; ovary; and testis. Human ortholog(s) of this gene implicated in several diseases, including acute lymphoblastic leukemia; atypical hemolytic-uremic syndrome; eye disease (multiple); glomerulonephritis (multiple); and sickle cell anemia. Orthologous to human CFB (complement factor B); PARTICIPATES IN coagulation cascade pathway; complement system pathway; Staphylococcus aureus infection pathway; INTERACTS WITH 1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane; 1,2-dimethylhydrazine; 17alpha-ethynylestradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: AI195813; AI255840; alternative-complement pathway C3/C5 convertase; B; Bf; C2; C3/C5 convertase; complement component 2 (within H-2S); Factor B; Fb; H2-Bf; histocompatibility 2, complement component factor B; properdin
Orthologs:
Homo sapiens (human) : CFB (complement factor B)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Cfb (complement factor B)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Cfb (complement factor B)
Pan paniscus (bonobo/pygmy chimpanzee) : CFB (complement factor B)
Canis lupus familiaris (dog) : CFB (complement factor B)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Cfb (complement factor B)
Sus scrofa (pig) : CFB (complement factor B)
Heterocephalus glaber (naked mole-rat) : Cfb (complement factor B)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm38.p6 Ensembl1734,856,374 - 34,862,518 (-)EnsemblGRCm38mm10GRCm38
GRCm381734,856,374 - 34,862,514 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv371734,993,319 - 34,999,459 (-)NCBIGRCm37mm9NCBIm37
MGSCv361734,464,437 - 34,470,273 (-)NCBImm8
Celera1737,951,682 - 37,957,822 (-)NCBICelera
Cytogenetic Map17B1NCBI
cM Map1718.41NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters

Additional Information

External Database Links
 
More on Cfb
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 10236
Created: 2000-05-25
Species: Mus musculus
Last Modified: 2020-09-23
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.