Cfb (complement factor B) - Rat Genome Database

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Gene: Cfb (complement factor B) Mus musculus
Analyze
Symbol: Cfb
Name: complement factor B
RGD ID: 10236
MGI Page MGI
Description: Predicted to enable serine-type endopeptidase activity. Acts upstream of or within complement activation, alternative pathway. Predicted to be located in extracellular region. Is expressed in embryo and liver lobe. Human ortholog(s) of this gene implicated in several diseases, including atypical hemolytic-uremic syndrome; autoimmune disease (multiple); eye disease (multiple); glomerulonephritis (multiple); and sickle cell anemia. Orthologous to human CFB (complement factor B); PARTICIPATES IN coagulation cascade pathway; complement system pathway; Staphylococcus aureus infection pathway; INTERACTS WITH 1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane; 1,2-dimethylhydrazine; 17alpha-ethynylestradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: AI195813; AI255840; alternative-complement pathway C3/C5 convertase; B; Bf; C2; C3/C5 convertase; complement component 2 (within H-2S); Factor B; Fb; H2-Bf; histocompatibility 2, complement component factor B; properdin
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391735,075,350 - 35,081,492 (-)NCBIGRCm39mm39
GRCm39 Ensembl1735,075,350 - 35,081,494 (-)Ensembl
GRCm381734,856,374 - 34,862,514 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1734,856,374 - 34,862,518 (-)EnsemblGRCm38mm10GRCm38
MGSCv371734,993,319 - 34,999,459 (-)NCBIGRCm37mm9NCBIm37
MGSCv361734,464,437 - 34,470,273 (-)NCBImm8
Celera1737,951,682 - 37,957,822 (-)NCBICelera
Cytogenetic Map17B1NCBI
cM Map1718.41NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
acute lymphoblastic leukemia  (ISO)
age related macular degeneration 14  (ISO)
age related macular degeneration 7  (ISO)
Anemia, Refractory, with Excess of Blasts  (ISO)
anterior uveitis  (ISO)
anti-basement membrane glomerulonephritis  (IMP)
atypical hemolytic-uremic syndrome  (ISO)
autosomal dominant polycystic kidney disease  (ISO)
Behcet's disease  (ISO)
beta thalassemia  (ISO)
boutonneuse fever  (ISO)
Brain Injuries  (ISO)
breast cancer  (ISO)
bullous pemphigoid  (IMP)
Choroidal Neovascularization  (IMP)
complement component 2 deficiency  (ISO)
Complement Factor B Deficiency  (ISO)
conjunctivitis  (ISO)
diabetic retinopathy  (ISO)
end stage renal disease  (IMP,ISO)
erythema nodosum  (ISO)
Experimental Autoimmune Myasthenia Gravis  (ISO)
Experimental Autoimmune Uveoretinitis  (IEP,ISO)
factor VIII deficiency  (ISO)
focal segmental glomerulosclerosis  (IMP)
IgA glomerulonephritis  (ISO)
Kidney Reperfusion Injury  (IMP)
lepromatous leprosy  (ISO)
lupus nephritis  (IEP,IMP,ISO)
macular degeneration  (ISO)
membranoproliferative glomerulonephritis  (IMP,ISO)
membranous glomerulonephritis  (ISO)
Meningococcal Infections  (ISO)
Multifocal Choroiditis  (ISO)
myasthenia gravis  (ISO)
otitis media  (IMP)
paracoccidioidomycosis  (ISO)
polycystic kidney disease  (IEP)
Polypoidal Choroidal Vasculopathy  (ISO)
psoriasis  (ISO)
pyelonephritis  (ISO)
retinal degeneration  (ISO)
Sepsis  (IMP)
sickle cell anemia  (ISO)
sinusitis  (ISO)
systemic lupus erythematosus  (ISO)
systemic scleroderma  (ISO)
type 1 diabetes mellitus  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (ISO)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (EXP,ISO)
1,2-dimethylhydrazine  (EXP)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 3-benzoate  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2,3-dimethoxynaphthalene-1,4-dione  (ISO)
2,4-dinitrotoluene  (ISO)
2-hydroxypropanoic acid  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3,4-methylenedioxymethamphetamine  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-diaminodiphenylmethane  (EXP)
4-hydroxynon-2-enal  (EXP)
4-hydroxyphenyl retinamide  (EXP)
6-propyl-2-thiouracil  (ISO)
acetamide  (ISO)
acrylamide  (ISO)
aflatoxin B1  (EXP,ISO)
all-trans-retinoic acid  (ISO)
antimony(0)  (ISO)
antirheumatic drug  (ISO)
aripiprazole  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
azoxystrobin  (ISO)
benzene  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[b]fluoranthene  (EXP)
bis(2-chloroethyl) sulfide  (EXP)
bisphenol A  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
calcium atom  (EXP)
calcium(0)  (EXP)
carbon nanotube  (EXP,ISO)
chlordecone  (EXP)
chlorpyrifos  (ISO)
chromium atom  (ISO)
chrysene  (EXP)
cobalt dichloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
cyclophosphamide  (EXP)
cyclosporin A  (EXP,ISO)
danazol  (ISO)
dexamethasone  (EXP,ISO)
diarsenic trioxide  (ISO)
dichloroacetic acid  (EXP)
diethylstilbestrol  (EXP)
dipotassium bis[mu-tartrato(4-)]diantimonate(2-) trihydrate  (ISO)
disulfiram  (ISO)
diuron  (ISO)
doxorubicin  (EXP,ISO)
fenvalerate  (ISO)
flutamide  (ISO)
folic acid  (EXP)
fonofos  (ISO)
formaldehyde  (ISO)
furan  (ISO)
glyphosate  (ISO)
hydrogen peroxide  (ISO)
imidacloprid  (ISO)
indometacin  (ISO)
L-ascorbic acid  (ISO)
lead(0)  (ISO)
lead(2+)  (ISO)
lipopolysaccharide  (EXP)
magnesium atom  (EXP)
mercury atom  (ISO)
mercury dichloride  (EXP)
mercury(0)  (ISO)
metam  (EXP)
mifepristone  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
N-nitrosodiethylamine  (ISO)
N-Nitrosopyrrolidine  (ISO)
naphthalene  (EXP)
nefazodone  (ISO)
nickel atom  (ISO)
O-methyleugenol  (ISO)
olanzapine  (ISO)
ozone  (ISO)
paclitaxel  (ISO)
paracetamol  (ISO)
parathion  (ISO)
parthenolide  (ISO)
perfluorooctane-1-sulfonic acid  (EXP)
perfluorooctanoic acid  (EXP,ISO)
pirinixic acid  (EXP)
potassium chromate  (ISO)
potassium dichromate  (ISO)
progesterone  (EXP)
propanal  (ISO)
protein kinase inhibitor  (ISO)
quercetin  (ISO)
rac-lactic acid  (ISO)
silicon dioxide  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
tamoxifen  (EXP)
temozolomide  (ISO)
terbufos  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone  (ISO)
tetrachloromethane  (EXP,ISO)
tetraphene  (EXP)
thiabendazole  (ISO)
titanium dioxide  (EXP)
tolcapone  (ISO)
Triptolide  (EXP)
troglitazone  (ISO)
valproic acid  (ISO)
vinclozolin  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
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Additional References at PubMed
PMID:1203052   PMID:1351875   PMID:1370685   PMID:1970336   PMID:2229060   PMID:2652811   PMID:3034587   PMID:3353717   PMID:6088393   PMID:6316336   PMID:6550027   PMID:6626149  
PMID:6689022   PMID:6816725   PMID:6885117   PMID:6919506   PMID:6980940   PMID:7641699   PMID:7916002   PMID:8624034   PMID:8700167   PMID:8706013   PMID:8824158   PMID:8939972  
PMID:9238044   PMID:9430715   PMID:9507200   PMID:9600320   PMID:10229798   PMID:10349636   PMID:11042159   PMID:11067947   PMID:11076861   PMID:11217851   PMID:11283677   PMID:11283678  
PMID:11359841   PMID:11560991   PMID:11804945   PMID:11869678   PMID:12077276   PMID:12193734   PMID:12196286   PMID:12466851   PMID:12477932   PMID:12794146   PMID:12930357   PMID:14656967  
PMID:14660741   PMID:14670299   PMID:15048732   PMID:15059809   PMID:15102802   PMID:15147568   PMID:15322019   PMID:15489334   PMID:15597324   PMID:15747579   PMID:15879138   PMID:15972690  
PMID:16002707   PMID:16034123   PMID:16141072   PMID:16141073   PMID:16272350   PMID:16304047   PMID:16615889   PMID:16651386   PMID:16670320   PMID:16702544   PMID:16842619   PMID:16849503  
PMID:16944957   PMID:17015743   PMID:17200182   PMID:17237432   PMID:17330941   PMID:17409188   PMID:17420242   PMID:17475881   PMID:17482263   PMID:17523212   PMID:17675237   PMID:17916747  
PMID:18056835   PMID:18160458   PMID:18452991   PMID:18501966   PMID:18524992   PMID:18541650   PMID:18672286   PMID:18684964   PMID:18820683   PMID:19112490   PMID:19264882   PMID:19273909  
PMID:19277984   PMID:19843088   PMID:20004473   PMID:20033053   PMID:20152175   PMID:20413727   PMID:20660348   PMID:20675597   PMID:20709903   PMID:20870940   PMID:20952585   PMID:20974996  
PMID:21257205   PMID:21267068   PMID:21502512   PMID:21502587   PMID:21642543   PMID:21677750   PMID:21943708   PMID:22079428   PMID:22156595   PMID:22308431   PMID:22457620   PMID:22566568  
PMID:22689574   PMID:22750071   PMID:22819137   PMID:22830570   PMID:22918646   PMID:23028050   PMID:23337717   PMID:23427256   PMID:23825688   PMID:24167262   PMID:24194600   PMID:24378428  
PMID:24474777   PMID:24668752   PMID:24740152   PMID:24743949   PMID:25593023   PMID:25645888   PMID:25725105   PMID:26787717   PMID:27064393   PMID:27295359   PMID:27564415   PMID:27626380  
PMID:28250926   PMID:28301559   PMID:28662037   PMID:29137982   PMID:29233958   PMID:29279353   PMID:29497373   PMID:29531168   PMID:30174588   PMID:30301856   PMID:31040226   PMID:32369457  
PMID:33410734   PMID:33613523   PMID:33740660  


Genomics

Comparative Map Data
Cfb
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391735,075,350 - 35,081,492 (-)NCBIGRCm39mm39
GRCm39 Ensembl1735,075,350 - 35,081,494 (-)Ensembl
GRCm381734,856,374 - 34,862,514 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1734,856,374 - 34,862,518 (-)EnsemblGRCm38mm10GRCm38
MGSCv371734,993,319 - 34,999,459 (-)NCBIGRCm37mm9NCBIm37
MGSCv361734,464,437 - 34,470,273 (-)NCBImm8
Celera1737,951,682 - 37,957,822 (-)NCBICelera
Cytogenetic Map17B1NCBI
cM Map1718.41NCBI
CFB
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl631,945,650 - 31,952,084 (+)EnsemblGRCh38hg38GRCh38
GRCh38631,946,095 - 31,952,084 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37631,913,872 - 31,919,861 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36632,021,752 - 32,027,839 (+)NCBINCBI36hg18NCBI36
Build 34632,021,760 - 32,027,839NCBI
Celera633,513,483 - 33,519,623 (+)NCBI
Cytogenetic Map6p21.33NCBI
HuRef631,700,690 - 31,706,830 (+)NCBIHuRef
CHM1_1631,915,802 - 31,921,942 (+)NCBICHM1_1
Cfb
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2203,970,643 - 3,976,510 (+)NCBImRatBN7.2
Rnor_6.0204,536,206 - 4,542,073 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl204,536,212 - 4,542,073 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0 Ensembl204,536,203 - 4,561,066 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0206,616,005 - 6,621,872 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera204,054,184 - 4,060,051 (-)NCBICelera
Cytogenetic Map20p12NCBI
Cfb
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_004955437461,235 - 466,908 (+)NCBIChiLan1.0ChiLan1.0
CFB
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1632,492,982 - 32,499,396 (+)NCBIpanpan1.1PanPan1.1panPan2
Mhudiblu_PPA_v0631,606,716 - 31,612,782 (+)NCBIMhudiblu_PPA_v0panPan3
CFB
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1121,400,143 - 1,406,267 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha121,535,347 - 1,541,465 (+)NCBI
ROS_Cfam_1.0121,542,448 - 1,548,565 (+)NCBI
UMICH_Zoey_3.1121,399,726 - 1,405,840 (+)NCBI
UNSW_CanFamBas_1.0121,468,093 - 1,474,210 (+)NCBI
UU_Cfam_GSD_1.0121,533,422 - 1,539,539 (+)NCBI
Cfb
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494635,959,298 - 35,965,192 (+)NCBI
SpeTri2.0NW_0049367271,595,872 - 1,602,274 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CFB
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1724,034,077 - 24,040,523 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2727,771,678 - 27,777,773 (-)NCBISscrofa10.2Sscrofa10.2susScr3
CFB
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Vero_WHO_p1.0NW_02366604431,862,788 - 31,868,803 (+)NCBI
Cfb
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462475424,310,344 - 24,316,482 (-)NCBI

Position Markers
AI255840  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381734,856,482 - 34,856,579UniSTSGRCm38
MGSCv371734,993,427 - 34,993,524UniSTSGRCm37
Celera1737,951,790 - 37,951,887UniSTS
Cytogenetic Map17B1UniSTS
cM Map1718.85UniSTS
cM Map1718.84UniSTS
Whitehead/MRC_RH17468.4UniSTS
D17916  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381734,856,410 - 34,856,582UniSTSGRCm38
MGSCv371734,993,355 - 34,993,527UniSTSGRCm37
Celera1737,951,718 - 37,951,890UniSTS
Cytogenetic Map17B1UniSTS
cM Map1718.85UniSTS
cM Map1718.84UniSTS
Whitehead_YAC17 UniSTS
AI195813  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map17B1UniSTS
cM Map1718.85UniSTS
Whitehead/MRC_RH17473.2UniSTS
M57891  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381734,862,650 - 34,862,755UniSTSGRCm38
MGSCv371734,999,595 - 34,999,700UniSTSGRCm37
Celera1737,957,958 - 37,958,063UniSTS
Cytogenetic Map17B1UniSTS
cM Map1718.86UniSTS
cM Map1718.85UniSTS
Whitehead/MRC_RH17463.75UniSTS
C2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381734,862,925 - 34,864,086UniSTSGRCm38
MGSCv371734,999,870 - 35,001,031UniSTSGRCm37
Celera1737,958,233 - 37,959,394UniSTS
Cytogenetic Map17B1UniSTS
cM Map1718.86UniSTS
Cfb  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381734,856,462 - 34,856,534UniSTSGRCm38
MGSCv371734,993,407 - 34,993,479UniSTSGRCm37
Celera1737,951,770 - 37,951,842UniSTS
Cytogenetic Map17B1UniSTS
cM Map1718.41UniSTS


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
10412276Leci2_mleukocyte endothelial cell interactions 2 (mouse)Not determined17312791337128037Mouse
1300890Bhr3_mbronchial hyperresponsiveness 3 (mouse)Not determined17392461548559063Mouse
4141215Mnic1_mmacronutrient intake, carbohydrate 1 (mouse)Not determined480447745359340Mouse
1300706Alan1_malloantigen response 1 (mouse)Not determined17480447746158776Mouse
1357789Kdnw3_mkidney weight 3 (mouse)Not determined17480447747574740Mouse
4141272Tfv1_mtotal food volume 1 (mouse)Not determined480447765330362Mouse
10043949Pbft7_mpercent body fat 7 (mouse)Not determined17667496240674962Mouse
1301935Skull24_mskull morphology 24 (mouse)Not determined17836594042366175Mouse
1300787Cd8mts5_mCD8 memory T cell subset 5 (mouse)Not determined17836594042366175Mouse
1301338Lmr1_mleishmaniasis resistance 1 (mouse)Not determined17986241186688972Mouse
1302028Asbb3_mautoimmune susceptibility in C57BL/6J and BALB/c 3 (mouse)Not determined171065914544659245Mouse
4142342Lfnq4_mlung function QTL 4 (mouse)Not determined1098759739053168Mouse
4141067Hbnr2_mHeligmosomoides bakeri nematode resistance 2 (mouse)Not determined1166699745667145Mouse
14747010Mancz14_mmandible centroid size 14 (mouse)171177921045779210Mouse
4142150Stheal11_msoft tissue heal 11 (mouse)Not determined171206732483054339Mouse
12904946Tammq8_mtibialis anterior muscle mass QTL 8 (mouse)171223281346232813Mouse
13524847Asrq8a_macoustic startle response 8a (mouse)171242798746427987Mouse
11081168Tir7_mtrypanosome infection response 7 (mouse)171390439847904522Mouse
1300914Pcir4_mperiosteal circumference 4 (mouse)Not determined171484267848842786Mouse
1558886Lgth9_mbody length 9 (mouse)Not determined171484267848842786Mouse
1302070Tbbmd7_mtotal body bone mineral density 7 (mouse)Not determined171484267848842786Mouse
1300995Fembrs4_mfemur breaking strength 4 (mouse)Not determined171484267848842786Mouse
1302140Wta4_mweight adult 4 (mouse)Not determined171660074750600869Mouse
1302152Skull25_mskull morphology 25 (mouse)Not determined171660074750600869Mouse
1301505Tir1_mtrypanosome infection response 1 (mouse)Not determined171660074750600869Mouse
10412083Sm2_msusceptibility to Schistosoma mansoni infection 2 (mouse)Not determined171681096950811104Mouse
1302042Acsns3_mAngiostrongylus costaricensis nematode susceptibility 3 (mouse)Not determined171724323451243371Mouse
1300535Char3_mP. chabaudi malaria resistance QTL 3 (mouse)Not determined171724323451243371Mouse
10412214Sxbq3_mSGC/Knj cross B6 QTL 3 (mouse)Not determined171724323451243371Mouse
13452396Leusq3_mleucocytosis susceptibility QTL 3 (mouse)171724323451243371Mouse
13452399Leusq6_mleucocytosis susceptibility QTL 6 (mouse)171724323451243371Mouse
1301840Ssial4_msusceptibility to sialadenitiss 4 (mouse)Not determined171795643651959238Mouse
1301331Lbw1_mlupus NZB x NZW 1 (mouse)Not determined171819938152202007Mouse
1301056Pas2_mpulmonary adenoma susceptibility 2 (mouse)Not determined171820316552205351Mouse
15039354Nmrs36_mNAFLD-associated magnetic resonance shift 36 (mouse)171883413352834133Mouse
1301454Eae5_msusceptibility to experimental allergic encephalomyelitis 5 (mouse)Not determined172430185958301973Mouse
10412198Sst5_msusceptibility to tuberculosis 5 (mouse)Not determined172485760955405969Mouse
10412196Bbaa28_mB.burgdorferi-associated arthritis 28 (mouse)Not determined172536594043665344Mouse
10412204Bbaa29_mB.burgdorferi-associated arthritis 29 (mouse)Not determined172574029459740461Mouse
1558758Kcal2_mkilocalorie 2 (mouse)Not determined172618203852604676Mouse
1300602Eye2_meye weight 2 (mouse)Not determined172628636340794146Mouse
1302005Loco2_mlocomotor activity 2 (mouse)Not determined172657408160574223Mouse
11075105Modc1_mmodifier of Odc1 (mouse)172749681845311728Mouse
15039348Nmrs37_mNAFLD-associated magnetic resonance shift 37 (mouse)172750432261504322Mouse
10045977Tir9_mtrypanosome infection response 9 (mouse)Not determined172765914543574223Mouse
1300703Uvbi2_mUVB induced immunosuppression 2 (mouse)Not determined172831148062311728Mouse
1300589Myaa2_mmodifier of Yaa 2 (mouse)Not determined172982162963821740Mouse
4140955Plgr1_mplague resistance locus 1 (mouse)Not determined3072257564722705Mouse
4141357Mrdq1_mmodifier of retinal degeneration QTL 1 (mouse)Not determined3076892947728778Mouse
1300692Blmpf1_mbleomycin-induced pulmonary fibrosis 1 (mouse)Not determined173184267837333884Mouse
25394538Skmw84_mskeletal muscle weight 84, TA (mouse)173244145235301060Mouse
26884379Skwq5_mskull length QTL 5, 5 week (mouse)173290000053800000Mouse
1302189Dps3_mdelta power in slow-wave sleep 3 (mouse)Not determined173360074735939288Mouse
1301759Sles1_msystemic lupus erythmatosus suppressor 1 (mouse)Not determined173400091634956961Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:957
Count of miRNA genes:370
Interacting mature miRNAs:440
Transcripts:ENSMUST00000025229, ENSMUST00000128767, ENSMUST00000133127, ENSMUST00000141295, ENSMUST00000153400, ENSMUST00000154526, ENSMUST00000176203
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001142706 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_008198 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006523671 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006523672 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AF049850 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF109906 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AH001868 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AH002015 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK098094 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK149531 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK149573 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK151220 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK151246 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK151618 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK151974 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC005451 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BP766400 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CA492475 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466666 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CT573030 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CU406965 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CU463176 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  K01496 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M57890 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSMUST00000025229   ⟹   ENSMUSP00000025229
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1735,075,360 - 35,081,490 (-)Ensembl
GRCm38.p6 Ensembl1734,856,384 - 34,862,514 (-)Ensembl
RefSeq Acc Id: ENSMUST00000128767   ⟹   ENSMUSP00000119977
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1735,075,350 - 35,081,494 (-)Ensembl
GRCm38.p6 Ensembl1734,856,374 - 34,862,518 (-)Ensembl
RefSeq Acc Id: ENSMUST00000133127   ⟹   ENSMUSP00000118360
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1735,075,550 - 35,078,017 (-)Ensembl
GRCm38.p6 Ensembl1734,856,574 - 34,859,041 (-)Ensembl
RefSeq Acc Id: ENSMUST00000141295   ⟹   ENSMUSP00000118945
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1735,075,350 - 35,078,001 (-)Ensembl
GRCm38.p6 Ensembl1734,856,374 - 34,859,025 (-)Ensembl
RefSeq Acc Id: ENSMUST00000153400   ⟹   ENSMUSP00000116497
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1735,075,367 - 35,077,118 (-)Ensembl
GRCm38.p6 Ensembl1734,856,391 - 34,858,142 (-)Ensembl
RefSeq Acc Id: ENSMUST00000154526   ⟹   ENSMUSP00000120990
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1735,075,355 - 35,081,149 (-)Ensembl
GRCm38.p6 Ensembl1734,856,379 - 34,862,173 (-)Ensembl
RefSeq Acc Id: ENSMUST00000176203   ⟹   ENSMUSP00000135660
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1735,075,360 - 35,081,490 (-)Ensembl
GRCm38.p6 Ensembl1734,856,384 - 34,862,514 (-)Ensembl
RefSeq Acc Id: ENSMUST00000176332   ⟹   ENSMUSP00000135304
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1735,075,388 - 35,078,286 (-)Ensembl
GRCm38.p6 Ensembl1734,856,412 - 34,859,310 (-)Ensembl
RefSeq Acc Id: NM_001142706   ⟹   NP_001136178
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391735,075,350 - 35,081,490 (-)NCBI
GRCm381734,856,374 - 34,862,514 (-)ENTREZGENE
MGSCv371734,993,319 - 34,999,459 (-)RGD
Celera1737,951,682 - 37,957,822 (-)RGD
cM Map17 ENTREZGENE
Sequence:
RefSeq Acc Id: NM_008198   ⟹   NP_032224
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391735,075,350 - 35,081,490 (-)NCBI
GRCm381734,856,374 - 34,862,514 (-)ENTREZGENE
MGSCv371734,993,319 - 34,999,459 (-)RGD
Celera1737,951,682 - 37,957,822 (-)RGD
cM Map17 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006523671   ⟹   XP_006523734
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391735,075,356 - 35,081,492 (-)NCBI
GRCm381734,856,380 - 34,862,320 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006523672   ⟹   XP_006523735
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391735,075,852 - 35,081,492 (-)NCBI
GRCm381734,856,876 - 34,862,513 (-)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_032224   ⟸   NM_008198
- Peptide Label: isoform 1 precursor
- UniProtKB: B8JJM5 (UniProtKB/TrEMBL),   Q3UEG8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001136178   ⟸   NM_001142706
- Peptide Label: isoform 2 precursor
- UniProtKB: B8JJM6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006523734   ⟸   XM_006523671
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_006523735   ⟸   XM_006523672
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: ENSMUSP00000118360   ⟸   ENSMUST00000133127
RefSeq Acc Id: ENSMUSP00000120990   ⟸   ENSMUST00000154526
RefSeq Acc Id: ENSMUSP00000119977   ⟸   ENSMUST00000128767
RefSeq Acc Id: ENSMUSP00000116497   ⟸   ENSMUST00000153400
RefSeq Acc Id: ENSMUSP00000025229   ⟸   ENSMUST00000025229
RefSeq Acc Id: ENSMUSP00000135304   ⟸   ENSMUST00000176332
RefSeq Acc Id: ENSMUSP00000135660   ⟸   ENSMUST00000176203
RefSeq Acc Id: ENSMUSP00000118945   ⟸   ENSMUST00000141295
Protein Domains
Peptidase S1   Sushi   VWFA

Promoters
RGD ID:13675748
Promoter ID:EPDNEW_M22023
Type:initiation region
Name:Cfb_1
Description:Mus musculus complement factor B , transcript variant 1, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M22024  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381734,862,216 - 34,862,276EPDNEW
RGD ID:13675750
Promoter ID:EPDNEW_M22024
Type:initiation region
Name:Cfb_2
Description:Mus musculus complement factor B , transcript variant 1, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M22023  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381734,862,518 - 34,862,578EPDNEW
RGD ID:6847368
Promoter ID:MM_ACW:22553
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   Kidney,   Liver,   Lung
Transcripts:CFB.DSEP07-UNSPLICED,   CFB.GSEP07-UNSPLICED,   CFB.HSEP07
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361734,993,471 - 34,994,517 (-)MPROMDB
RGD ID:6827929
Promoter ID:MM_KWN:23230
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   Kidney,   Liver,   Lung,   MEF_B6
Transcripts:OTTMUST00000085841
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361734,995,071 - 34,995,872 (-)MPROMDB
RGD ID:6827931
Promoter ID:MM_KWN:23231
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   Kidney,   Liver,   Lung
Transcripts:OTTMUST00000085840,   OTTMUST00000085842
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361734,996,074 - 34,996,574 (-)MPROMDB
RGD ID:6847369
Promoter ID:MM_ACW:22554
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_0Hour
Transcripts:CFB.FSEP07-UNSPLICED
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361734,998,471 - 34,998,971 (-)MPROMDB
RGD ID:6827927
Promoter ID:MM_KWN:23232
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_2Hour,   BoneMarrow_4Hour,   Kidney,   Liver
Transcripts:NM_001142706,   OTTMUST00000085838
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361734,999,111 - 34,999,611 (-)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:105975 AgrOrtholog
Ensembl Genes ENSMUSG00000024371
  ENSMUSG00000090231 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSMUSP00000025229 ENTREZGENE, UniProtKB/TrEMBL
  ENSMUSP00000116497 UniProtKB/TrEMBL
  ENSMUSP00000118360 UniProtKB/TrEMBL
  ENSMUSP00000118945 UniProtKB/TrEMBL
  ENSMUSP00000119977 UniProtKB/Swiss-Prot
  ENSMUSP00000120990 UniProtKB/TrEMBL
  ENSMUSP00000135304 UniProtKB/TrEMBL
  ENSMUSP00000135660 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000025229 ENTREZGENE, UniProtKB/TrEMBL
  ENSMUST00000128767 UniProtKB/Swiss-Prot
  ENSMUST00000133127 UniProtKB/TrEMBL
  ENSMUST00000141295 UniProtKB/TrEMBL
  ENSMUST00000153400 UniProtKB/TrEMBL
  ENSMUST00000154526 UniProtKB/TrEMBL
  ENSMUST00000176203 ENTREZGENE, UniProtKB/TrEMBL
  ENSMUST00000176332 UniProtKB/TrEMBL
Gene3D-CATH 2.40.10.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.40.50.410 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Compl_C2_B UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Complement_B UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_S1_PA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_S1_PA_chymotrypsin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Peptidase_S1A UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Sushi/SCR/CCP_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Sushi_SCR_CCP_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Trypsin_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TRYPSIN_HIS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TRYPSIN_SER UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  VWF_A UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  vWFA_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:14962 UniProtKB/TrEMBL
MGD MGI:105975 ENTREZGENE
NCBI Gene 14962 ENTREZGENE
PANTHER PTHR46393 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR46393:SF1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Sushi UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Trypsin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  VWA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Cfb PhenoGen
PIRSF Compl_C2_B UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Complement_B UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PRINTS CHYMOTRYPSIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE SUSHI UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TRYPSIN_DOM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TRYPSIN_HIS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TRYPSIN_SER UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  VWFA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART CCP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Tryp_SPc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  VWA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF50494 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF53300 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF57535 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt B8JJM3_MOUSE UniProtKB/TrEMBL
  B8JJM5 ENTREZGENE, UniProtKB/TrEMBL
  B8JJM6 ENTREZGENE, UniProtKB/TrEMBL
  CFAB_MOUSE UniProtKB/Swiss-Prot
  F6W2T4_MOUSE UniProtKB/TrEMBL
  F6WZA2_MOUSE UniProtKB/TrEMBL
  F6XQ00_MOUSE UniProtKB/TrEMBL
  H3BK95_MOUSE UniProtKB/TrEMBL
  P04186 ENTREZGENE
  Q3U925_MOUSE UniProtKB/TrEMBL
  Q3U9W1_MOUSE UniProtKB/TrEMBL
  Q3UAS8_MOUSE UniProtKB/TrEMBL
  Q3UEG8 ENTREZGENE, UniProtKB/TrEMBL