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Gene: Cfb (complement factor B) Rattus norvegicus
Symbol: Cfb
Name: complement factor B
Description: Predicted to have G protein-coupled receptor activity and serine-type endopeptidase activity. Involved in complement activation; response to lipopolysaccharide; and response to thyroid hormone. Localizes to extracellular space. Biomarker of polycystic kidney disease and retinal degeneration. Human ortholog(s) of this gene implicated in several diseases, including acute lymphoblastic leukemia; atypical hemolytic-uremic syndrome; eye disease (multiple); glomerulonephritis (multiple); and sickle cell anemia. Orthologous to human CFB (complement factor B); PARTICIPATES IN coagulation cascade pathway; complement system pathway; Staphylococcus aureus infection pathway; INTERACTS WITH 1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane; 17alpha-ethynylestradiol; 17beta-estradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: B-factor, properdin; Bf; Da1-24; MGC94594; properdin factor B
Homo sapiens (human) : CFB (complement factor B)  HGNC  Alliance
Mus musculus (house mouse) : Cfb (complement factor B)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Cfb (complement factor B)
Pan paniscus (bonobo/pygmy chimpanzee) : CFB (complement factor B)
Canis lupus familiaris (dog) : CFB (complement factor B)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Cfb (complement factor B)
Sus scrofa (pig) : CFB (complement factor B)
Heterocephalus glaber (naked mole-rat) : Cfb (complement factor B)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
NCBI Annotation Information: Annotation category: suggests misassembly
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.0204,536,206 - 4,542,073 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl204,536,203 - 4,561,066 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0 Ensembl204,536,212 - 4,542,073 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0206,616,005 - 6,621,872 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera204,054,184 - 4,060,051 (-)NCBICelera
Cytogenetic Map20p12NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
More on Cfb
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 2204
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2020-06-09
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.