C2 (complement C2) - Rat Genome Database

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Gene: C2 (complement C2) Sus scrofa
Analyze
Symbol: C2
Name: complement C2
RGD ID: 14216932
Description: ENCODES a protein that exhibits hydrolase activity (inferred); peptidase activity (inferred); serine-type endopeptidase activity (inferred); INVOLVED IN response to nutrient (ortholog); ASSOCIATED WITH age related macular degeneration 14 (ortholog); Alzheimer's disease (ortholog); atypical hemolytic-uremic syndrome (ortholog); FOUND IN classical-complement-pathway C3/C5 convertase complex (ortholog); INTERACTS WITH bis(2-chloroethyl) sulfide
Type: protein-coding
RefSeq Status: PROVISIONAL
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl723,995,982 - 24,033,930 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1724,020,590 - 24,034,042 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2727,778,160 - 27,791,919 (-)NCBISscrofa10.2Sscrofa10.2susScr3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References
Additional References at PubMed
PMID:14681463   PMID:17145712   PMID:22763733  


Genomics

Comparative Map Data
C2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl723,995,982 - 24,033,930 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1724,020,590 - 24,034,042 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2727,778,160 - 27,791,919 (-)NCBISscrofa10.2Sscrofa10.2susScr3
C2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38631,897,783 - 31,945,672 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl631,897,785 - 31,945,673 (+)EnsemblGRCh38hg38GRCh38
GRCh37631,865,560 - 31,913,449 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36632,003,473 - 32,021,427 (+)NCBINCBI36Build 36hg18NCBI36
Build 34632,003,472 - 32,021,427NCBI
Celera633,495,068 - 33,513,211 (+)NCBICelera
Cytogenetic Map6p21.33NCBI
HuRef631,651,618 - 31,700,418 (+)NCBIHuRef
CHM1_1631,867,703 - 31,915,530 (+)NCBICHM1_1
T2T-CHM13v2.0631,751,025 - 31,798,877 (+)NCBIT2T-CHM13v2.0
C2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391735,081,578 - 35,101,076 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1735,081,580 - 35,117,241 (-)EnsemblGRCm39 Ensembl
GRCm381734,862,602 - 34,882,100 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1734,862,604 - 34,898,265 (-)EnsemblGRCm38mm10GRCm38
MGSCv371734,999,547 - 35,019,045 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361734,470,663 - 34,490,103 (-)NCBIMGSCv36mm8
Celera1737,957,910 - 37,977,407 (-)NCBICelera
Cytogenetic Map17B1NCBI
cM Map1718.41NCBI
C2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2203,951,474 - 3,970,376 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl203,951,474 - 3,976,505 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx204,651,385 - 4,670,381 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0204,013,128 - 4,032,129 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0204,550,327 - 4,569,295 (+)NCBIRnor_WKY
Rnor_6.0204,542,340 - 4,561,152 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl204,542,340 - 4,561,152 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0206,622,139 - 6,641,139 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4204,051,146 - 4,071,909 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1204,051,372 - 4,072,135 (+)NCBI
Celera204,060,318 - 4,078,802 (-)NCBICelera
Cytogenetic Map20p12NCBI
C2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955437448,672 - 460,519 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955437449,171 - 460,898 (+)NCBIChiLan1.0ChiLan1.0
C2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1632,476,791 - 32,492,982 (+)NCBIpanpan1.1PanPan1.1panPan2
Mhudiblu_PPA_v0631,590,135 - 31,606,368 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
C2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1121,363,656 - 1,399,732 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl121,363,803 - 1,399,728 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha121,493,696 - 1,534,930 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0121,500,603 - 1,542,031 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl121,500,627 - 1,542,028 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1121,358,291 - 1,399,309 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0121,426,238 - 1,467,677 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0121,491,715 - 1,533,005 (+)NCBIUU_Cfam_GSD_1.0
C2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494635,913,518 - 35,958,946 (+)NCBIHiC_Itri_2
SpeTri2.0NW_0049367271,602,400 - 1,615,974 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
C2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11740,069,852 - 40,094,478 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1740,069,909 - 40,094,207 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604431,844,362 - 31,862,408 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
C2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462475424,316,778 - 24,327,065 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system hemolymphoid system musculoskeletal system nervous system renal system reproductive system respiratory system
High
Medium 8 2 4 3
Low 2 1 1 1 2 17 1 3
Below cutoff 1 2 6 1

Sequence


Reference Sequences
RefSeq Acc Id: ENSSSCT00000001563   ⟹   ENSSSCP00000001521
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl724,020,290 - 24,033,927 (+)Ensembl
RefSeq Acc Id: ENSSSCT00000001564   ⟹   ENSSSCP00000001522
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl724,020,626 - 24,033,930 (+)Ensembl
RefSeq Acc Id: ENSSSCT00000071648   ⟹   ENSSSCP00000067185
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl723,995,982 - 24,033,805 (+)Ensembl
RefSeq Acc Id: ENSSSCT00000090014   ⟹   ENSSSCP00000069191
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl724,020,626 - 24,033,805 (+)Ensembl
RefSeq Acc Id: NM_001101815   ⟹   NP_001095285
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1724,020,590 - 24,034,042 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001095285 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAR20890 (Get FASTA)   NCBI Sequence Viewer  
  CAN87699 (Get FASTA)   NCBI Sequence Viewer  
  CAN87700 (Get FASTA)   NCBI Sequence Viewer  
  JAG69686 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_001095285   ⟸   NM_001101815
- Peptide Label: precursor
- UniProtKB: A5PF02 (UniProtKB/TrEMBL),   A0A0B8RW16 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSSSCP00000001521   ⟸   ENSSSCT00000001563
RefSeq Acc Id: ENSSSCP00000069191   ⟸   ENSSSCT00000090014
RefSeq Acc Id: ENSSSCP00000067185   ⟸   ENSSSCT00000071648
RefSeq Acc Id: ENSSSCP00000001522   ⟸   ENSSSCT00000001564
Protein Domains
Peptidase S1   Sushi   VWFA


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000001422 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSSSCG00005042642 UniProtKB/TrEMBL
  ENSSSCG00025070078 UniProtKB/TrEMBL
  ENSSSCG00030053761 UniProtKB/TrEMBL
  ENSSSCG00045039233 UniProtKB/TrEMBL
  ENSSSCG00055025295 UniProtKB/TrEMBL
  ENSSSCG00070023255 UniProtKB/TrEMBL
Ensembl Protein ENSSSCP00000001521 ENTREZGENE
  ENSSSCP00000001521.3 UniProtKB/TrEMBL
  ENSSSCP00000067185.1 UniProtKB/TrEMBL
  ENSSSCP00000069191.1 UniProtKB/TrEMBL
  ENSSSCP00005042972.1 UniProtKB/TrEMBL
  ENSSSCP00025042862.1 UniProtKB/TrEMBL
  ENSSSCP00030034289.1 UniProtKB/TrEMBL
  ENSSSCP00045048589.1 UniProtKB/TrEMBL
  ENSSSCP00055041181.1 UniProtKB/TrEMBL
  ENSSSCP00070039131.1 UniProtKB/TrEMBL
  ENSSSCP00070039144.1 UniProtKB/TrEMBL
  ENSSSCP00070039145.1 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000001563 ENTREZGENE
  ENSSSCT00000001563.5 UniProtKB/TrEMBL
  ENSSSCT00000071648.1 UniProtKB/TrEMBL
  ENSSSCT00000090014.1 UniProtKB/TrEMBL
  ENSSSCT00005069093.1 UniProtKB/TrEMBL
  ENSSSCT00025097601.1 UniProtKB/TrEMBL
  ENSSSCT00030075004.1 UniProtKB/TrEMBL
  ENSSSCT00045068300.1 UniProtKB/TrEMBL
  ENSSSCT00055051527.1 UniProtKB/TrEMBL
  ENSSSCT00070046383.1 UniProtKB/TrEMBL
  ENSSSCT00070046398.1 UniProtKB/TrEMBL
  ENSSSCT00070046399.1 UniProtKB/TrEMBL
Gene3D-CATH 2.40.10.10 UniProtKB/TrEMBL
  3.40.50.410 UniProtKB/TrEMBL
InterPro Compl_C2_B UniProtKB/TrEMBL
  Complement_C2 UniProtKB/TrEMBL
  Peptidase_S1_PA UniProtKB/TrEMBL
  Peptidase_S1_PA_chymotrypsin UniProtKB/TrEMBL
  Peptidase_S1A UniProtKB/TrEMBL
  Sushi/SCR/CCP_sf UniProtKB/TrEMBL
  Sushi_SCR_CCP_dom UniProtKB/TrEMBL
  Trypsin_dom UniProtKB/TrEMBL
  TRYPSIN_HIS UniProtKB/TrEMBL
  TRYPSIN_SER UniProtKB/TrEMBL
  VWF_A UniProtKB/TrEMBL
  vWFA_dom_sf UniProtKB/TrEMBL
KEGG Report ssc:448981 UniProtKB/TrEMBL
NCBI Gene C2 ENTREZGENE
PANTHER PTHR46393 UniProtKB/TrEMBL
  PTHR46393:SF2 UniProtKB/TrEMBL
Pfam Sushi UniProtKB/TrEMBL
  Trypsin UniProtKB/TrEMBL
  VWA UniProtKB/TrEMBL
PIRSF Compl_C2_B UniProtKB/TrEMBL
PRINTS CHYMOTRYPSIN UniProtKB/TrEMBL
PROSITE SUSHI UniProtKB/TrEMBL
  TRYPSIN_DOM UniProtKB/TrEMBL
  TRYPSIN_HIS UniProtKB/TrEMBL
  TRYPSIN_SER UniProtKB/TrEMBL
  VWFA UniProtKB/TrEMBL
SMART CCP UniProtKB/TrEMBL
  Tryp_SPc UniProtKB/TrEMBL
  VWA UniProtKB/TrEMBL
Superfamily-SCOP SSF50494 UniProtKB/TrEMBL
  SSF53300 UniProtKB/TrEMBL
  SSF57535 UniProtKB/TrEMBL
UniProt A0A0B8RW16 ENTREZGENE
  A0A4X1V8C3_PIG UniProtKB/TrEMBL
  A0A4X1VC41_PIG UniProtKB/TrEMBL
  A0A4X1VEI5_PIG UniProtKB/TrEMBL
  A0A5G2QWF5_PIG UniProtKB/TrEMBL
  A0A5G2R9A6_PIG UniProtKB/TrEMBL
  A5PF02 ENTREZGENE, UniProtKB/TrEMBL
  A5PF03_PIG UniProtKB/TrEMBL
  F1RQW7_PIG UniProtKB/TrEMBL
VGNC ID VGNC:85989 ENTREZGENE