Derl3 (derlin 3) - Rat Genome Database

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Gene: Derl3 (derlin 3) Rattus norvegicus
Analyze
Symbol: Derl3
Name: derlin 3
RGD ID: 1597373
Description: Predicted to have misfolded protein binding activity; signal recognition particle binding activity; and ubiquitin-specific protease binding activity. Predicted to be involved in cellular protein metabolic process; endoplasmic reticulum unfolded protein response; and negative regulation of retrograde protein transport, ER to cytosol. Predicted to localize to Hrd1p ubiquitin ligase ERAD-L complex and integral component of endoplasmic reticulum membrane. Orthologous to human DERL3 (derlin 3); PARTICIPATES IN Endoplasmic Reticulum-associated degradation pathway; INTERACTS WITH (+)-schisandrin B; 17beta-estradiol; 17beta-estradiol 3-benzoate.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: Der1-like domain family, member 3; derlin-3; LOC103694875; LOC690315; similar to Der1-like domain family, member 3; uncharacterized protein LOC103694875
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.22012,754,490 - 12,768,454 (-)NCBI
Rnor_6.0 Ensembl2013,704,314 - 13,706,205 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.02013,692,102 - 13,707,645 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.02015,858,297 - 15,863,183 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42013,163,287 - 13,165,848 (-)NCBIRGSC3.4rn4RGSC3.4
Celera2014,255,751 - 14,258,312 (-)NCBICelera
Cytogenetic Map20p12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

Additional References at PubMed
PMID:12477932   PMID:16449189   PMID:19940266   PMID:22607976   PMID:25660456   PMID:26565908  


Genomics

Comparative Map Data
Derl3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.22012,754,490 - 12,768,454 (-)NCBI
Rnor_6.0 Ensembl2013,704,314 - 13,706,205 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.02013,692,102 - 13,707,645 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.02015,858,297 - 15,863,183 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42013,163,287 - 13,165,848 (-)NCBIRGSC3.4rn4RGSC3.4
Celera2014,255,751 - 14,258,312 (-)NCBICelera
Cytogenetic Map20p12NCBI
DERL3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl2223,834,503 - 23,839,128 (-)EnsemblGRCh38hg38GRCh38
GRCh382223,834,498 - 23,839,348 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh372224,176,690 - 24,181,193 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362222,506,690 - 22,511,201 (-)NCBINCBI36hg18NCBI36
Build 342222,501,245 - 22,505,755NCBI
Celera228,015,749 - 8,020,256 (-)NCBI
Cytogenetic Map22q11.23NCBI
HuRef227,164,611 - 7,169,120 (-)NCBIHuRef
CHM1_12224,188,905 - 24,193,409 (-)NCBICHM1_1
Derl3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391075,729,232 - 75,731,775 (+)NCBIGRCm39mm39
GRCm39 Ensembl1075,729,247 - 75,731,775 (+)Ensembl
GRCm381075,893,398 - 75,895,941 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1075,893,413 - 75,895,941 (+)EnsemblGRCm38mm10GRCm38
MGSCv371075,356,143 - 75,358,686 (+)NCBIGRCm37mm9NCBIm37
MGSCv361075,337,114 - 75,339,657 (+)NCBImm8
Celera1076,938,087 - 76,940,630 (+)NCBICelera
Cytogenetic Map10C1NCBI
Derl3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554558,415,839 - 8,421,762 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554558,415,868 - 8,418,753 (+)NCBIChiLan1.0ChiLan1.0
DERL3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.12222,673,908 - 22,678,451 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2222,673,908 - 22,678,444 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0224,589,448 - 4,594,628 (-)NCBIMhudiblu_PPA_v0panPan3
DERL3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12628,688,307 - 28,690,400 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2628,688,106 - 28,690,400 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2627,761,400 - 27,763,725 (+)NCBI
ROS_Cfam_1.02630,093,061 - 30,095,386 (+)NCBI
UMICH_Zoey_3.12628,174,380 - 28,176,705 (+)NCBI
UNSW_CanFamBas_1.02627,792,314 - 27,794,639 (+)NCBI
UU_Cfam_GSD_1.02628,780,177 - 28,785,974 (+)NCBI
Derl3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118141,478,848 - 141,482,070 (-)NCBI
SpeTri2.0NW_0049366191,271,980 - 1,275,212 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
DERL3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1449,871,218 - 49,877,683 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11449,871,077 - 49,875,022 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21453,313,332 - 53,315,464 (+)NCBISscrofa10.2Sscrofa10.2susScr3
DERL3
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1196,944,291 - 6,949,948 (-)NCBI
ChlSab1.1 Ensembl196,947,403 - 6,949,845 (-)Ensembl
Derl3
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462474710,357,560 - 10,359,779 (+)NCBI

Position Markers
MARC_9679-9680:996688523:1  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.02013,704,343 - 13,705,122NCBIRnor6.0
Rnor_5.02015,859,906 - 15,860,685UniSTSRnor5.0
RGSC_v3.42013,163,959 - 13,164,738UniSTSRGSC3.4
Celera2014,256,423 - 14,257,202UniSTS
Cytogenetic Map20p12UniSTS


QTLs in Region (Rnor_6.0)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1354642Despr15Despair related QTL 150.0027locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)20124652101Rat
1600382Edcs3Endometrial carcinoma susceptibility QTL33.50.003uterus morphology trait (VT:0001120)percentage of study population developing endometrioid carcinoma during a period of time (CMO:0001759)20125653396Rat
1641893Alcrsp7Alcohol response QTL 7response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)20126305996Rat
2317851Alcrsp22Alcohol response QTL 223.20.05response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)20126305996Rat
7387283Uae44Urinary albumin excretion QTL 440.1712urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)20127357423Rat
9590275Scort15Serum corticosterone level QTL 153.480.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)20128375393Rat
9589155Insul32Insulin level QTL 326.380.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)20128375393Rat
9590109Sffal8Serum free fatty acids level QTL 85.320.01blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)20128375393Rat
7411650Foco23Food consumption QTL 2320.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)20128375393Rat
8694189Bw153Body weight QTL 1533.130.001body mass (VT:0001259)body weight gain (CMO:0000420)20128375393Rat
6893685Bw111Body weight QTL 1112.70.004body mass (VT:0001259)body weight (CMO:0000012)20133300419Rat
9590252Scort12Serum corticosterone level QTL 1220.460.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)20137550487Rat
7411668Foco32Food consumption QTL 3280.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)20137550487Rat
2305926Iddm37Insulin dependent diabetes mellitus QTL 376blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)20201865447018654Rat
1641915Colcr9Colorectal carcinoma resistance QTL 92.970.0024intestine integrity trait (VT:0010554)benign colorectal tumor number (CMO:0001795)20299970747999707Rat
2317057Aia27Adjuvant induced arthritis QTL 272.83joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)20340211127968216Rat
1558640Prcs2Prostate cancer susceptibility QTL 23.3prostate integrity trait (VT:0010571)percentage of study population developing ventral prostate tumorous lesions during a period of time (CMO:0000943)20403911318872273Rat
4889857Pur27Proteinuria QTL 2712.20.001total urine protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)20403911318872273Rat
1598816Memor12Memory QTL 122.4exploratory behavior trait (VT:0010471)average horizontal distance in proximity to the target during voluntary locomotion in an experimental apparatus (CMO:0002674)20410895649108956Rat
61432Cia1Collagen induced arthritis QTL 1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)20485547515050565Rat
70154Insul2Insulin level QTL 23.75blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)20587544818739210Rat
1581577Pur15Proteinuria QTL 154.380.0002total urine protein amount (VT:0000032)urine protein excretion rate (CMO:0000759)20865434118872273Rat
4889870Pur30Proteinuria QTL 30190.005total urine protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)20865434130991290Rat
631265Iresp1Immunoglobin response QTL18.3blood anti-double stranded DNA antibody amount (VT:0004762)serum anti-DNA antibody level (CMO:0001533)20965564214411641Rat

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:85
Count of miRNA genes:72
Interacting mature miRNAs:82
Transcripts:ENSRNOT00000038623
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001109577 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006256325 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006256326 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008772914 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008772915 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008772916 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008772917 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008772918 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008772920 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008772922 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008772923 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008772924 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008773838 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008773839 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008773841 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008773842 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017601776 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039099084 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039099085 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039099086 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039099087 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039099089 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039099090 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC091362 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC167034 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473988 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JACYVU010000324 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSRNOT00000038623   ⟹   ENSRNOP00000029737
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl2013,704,314 - 13,706,205 (-)Ensembl
RefSeq Acc Id: NM_001109577   ⟹   NP_001103047
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.22012,764,466 - 12,767,027 (-)NCBI
Rnor_6.02013,703,671 - 13,706,232 (-)NCBI
Rnor_5.02015,858,297 - 15,863,183 (-)NCBI
RGSC_v3.42013,163,287 - 13,165,848 (-)RGD
Celera2014,255,751 - 14,258,312 (-)RGD
Sequence:
RefSeq Acc Id: XM_006256325   ⟹   XP_006256387
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.02013,702,924 - 13,707,645 (-)NCBI
Rnor_5.02015,858,297 - 15,863,183 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006256326   ⟹   XP_006256388
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.02013,703,675 - 13,707,645 (-)NCBI
Rnor_5.02015,858,297 - 15,863,183 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008772914   ⟹   XP_008771136
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.02013,703,675 - 13,706,203 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008772915   ⟹   XP_008771137
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.02013,703,675 - 13,706,203 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008772916   ⟹   XP_008771138
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.02013,702,924 - 13,706,203 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008772917   ⟹   XP_008771139
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.02013,692,102 - 13,706,203 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008772918   ⟹   XP_008771140
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.02013,703,675 - 13,707,645 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008772920   ⟹   XP_008771142
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.02013,703,675 - 13,707,645 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008772922   ⟹   XP_008771144
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.02013,703,675 - 13,707,645 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008772923   ⟹   XP_008771145
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.02013,703,675 - 13,706,203 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008772924   ⟹   XP_008771146
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.02013,703,675 - 13,706,203 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008773838   ⟹   XP_008772060
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.22012,761,747 - 12,768,453 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008773839   ⟹   XP_008772061
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.22012,761,747 - 12,768,454 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008773841   ⟹   XP_008772063
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.22012,761,747 - 12,768,447 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008773842   ⟹   XP_008772064
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.22012,761,747 - 12,768,451 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017601776   ⟹   XP_017457265
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.02013,703,675 - 13,707,645 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039099084   ⟹   XP_038955012
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.22012,761,747 - 12,768,454 (-)NCBI
RefSeq Acc Id: XM_039099085   ⟹   XP_038955013
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.22012,754,490 - 12,768,454 (-)NCBI
RefSeq Acc Id: XM_039099086   ⟹   XP_038955014
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.22012,761,747 - 12,768,454 (-)NCBI
RefSeq Acc Id: XM_039099087   ⟹   XP_038955015
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.22012,761,747 - 12,768,451 (-)NCBI
RefSeq Acc Id: XM_039099089   ⟹   XP_038955017
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.22012,761,747 - 12,768,453 (-)NCBI
RefSeq Acc Id: XM_039099090   ⟹   XP_038955018
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.22012,754,500 - 12,768,447 (-)NCBI
Reference Sequences
RefSeq Acc Id: NP_001103047   ⟸   NM_001109577
- UniProtKB: G3V8X2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006256387   ⟸   XM_006256325
- Peptide Label: isoform X7
- Sequence:
RefSeq Acc Id: XP_006256388   ⟸   XM_006256326
- Peptide Label: isoform X8
- Sequence:
RefSeq Acc Id: XP_008771139   ⟸   XM_008772917
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_008771138   ⟸   XM_008772916
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_008771144   ⟸   XM_008772922
- Peptide Label: isoform X4
- Sequence:
RefSeq Acc Id: XP_008771142   ⟸   XM_008772920
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: XP_008771140   ⟸   XM_008772918
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_008771146   ⟸   XM_008772924
- Peptide Label: isoform X6
- Sequence:
RefSeq Acc Id: XP_008771145   ⟸   XM_008772923
- Peptide Label: isoform X6
- Sequence:
RefSeq Acc Id: XP_008771137   ⟸   XM_008772915
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_008771136   ⟸   XM_008772914
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_017457265   ⟸   XM_017601776
- Peptide Label: isoform X5
- Sequence:
RefSeq Acc Id: ENSRNOP00000029737   ⟸   ENSRNOT00000038623
RefSeq Acc Id: XP_038955013   ⟸   XM_039099085
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038955018   ⟸   XM_039099090
- Peptide Label: isoform X7
RefSeq Acc Id: XP_038955014   ⟸   XM_039099086
- Peptide Label: isoform X4
RefSeq Acc Id: XP_038955012   ⟸   XM_039099084
- Peptide Label: isoform X1
RefSeq Acc Id: XP_008772061   ⟸   XM_008773839
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_038955017   ⟸   XM_039099089
- Peptide Label: isoform X6
RefSeq Acc Id: XP_008772060   ⟸   XM_008773838
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_008772064   ⟸   XM_008773842
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: XP_038955015   ⟸   XM_039099087
- Peptide Label: isoform X5
RefSeq Acc Id: XP_008772063   ⟸   XM_008773841
- Peptide Label: isoform X2
- UniProtKB: G3V8X2 (UniProtKB/TrEMBL)
- Sequence:

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13701530
Promoter ID:EPDNEW_R12054
Type:single initiation site
Name:LOC103694875_1
Description:derlin-3
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.02013,706,217 - 13,706,277EPDNEW

Strain Variation

Strain Sequence Variants (Rnor 6.0)
ACI/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
ACI/EurMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
ACI/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
BBDP/Wor (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
BN/SsN (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Buf/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
COP/CrCrl (MCW & UW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
University of Wisconsin (Dr. James Shull)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Charles River Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)
F344/NCrl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
F344/NRrrc (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
FHH/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHH/EurMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
FHL/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHL/EurMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
GH/OmrMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
GK/Ox (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LE/Stm (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/Crl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/NCrlBR (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LH/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LL/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LN/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
M520/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
MHS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MNS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MR/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
SBH/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBH/Ygl sequenced by MCW
SBH/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SBN/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBN/Ygl sequenced by MCW
SBN/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHR/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHRSP/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SR/JrHsd (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Harlan Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SR/JrHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/Jr (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/JrHsdMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SS/JrHsdMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WAG/Rij (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
WKY/NCrl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WN/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Damaging Variants


Assembly: Rnor_6.0

Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Strain
20 13705727 13705728 T A snv WN/N (MCW), CDR


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1597373 AgrOrtholog
Ensembl Genes ENSRNOG00000028243 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSRNOG00000055498 UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000029737 ENTREZGENE, UniProtKB/TrEMBL
  ENSRNOP00000074042 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000038623 ENTREZGENE, UniProtKB/TrEMBL
  ENSRNOT00000086463 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7303301 IMAGE-MGC_LOAD
InterPro DER1 UniProtKB/TrEMBL
KEGG Report rno:690315 UniProtKB/TrEMBL
MGC_CLONE MGC:189282 IMAGE-MGC_LOAD
NCBI Gene 690315 ENTREZGENE
Pfam DER1 UniProtKB/TrEMBL
PhenoGen Derl3 PhenoGen
UniProt B2RZ58_RAT UniProtKB/TrEMBL
  G3V8X2 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-03-09 Derl3  derlin 3  LOC103694875  derlin-3  Data Merged 737654 PROVISIONAL
2014-08-25 LOC103694875  derlin-3      Symbol and Name status set to provisional 70820 PROVISIONAL
2012-07-16 Derl3  derlin 3  Derl3  Der1-like domain family, member 3  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-03-06 Derl3  Der1-like domain family, member 3  LOC690315  similar to Der1-like domain family, member 3  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-11-20 LOC690315  similar to Der1-like domain family, member 3      Symbol and Name status set to provisional 70820 PROVISIONAL