G4 (G4 protein) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: G4 (G4 protein) Rattus norvegicus
Analyze
Symbol: G4
Name: G4 protein
RGD ID: 1303038
Description: Orthologous to human C6orf47 (chromosome 6 open reading frame 47); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene; bisphenol A.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: MGC124525; uncharacterized protein C6orf47 homolog
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8203,698,359 - 3,701,036 (-)NCBIGRCr8
mRatBN7.2203,693,691 - 3,696,194 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl203,693,649 - 3,696,088 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx204,392,867 - 4,395,193 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0203,754,924 - 3,757,250 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0204,292,702 - 4,295,027 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0205,118,006 - 5,120,332 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl205,118,002 - 5,120,332 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0207,191,210 - 7,193,591 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4203,757,345 - 3,759,671 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1203,758,257 - 3,759,139 (-)NCBI
Celera204,329,625 - 4,331,951 (+)NCBICelera
Cytogenetic Map20p12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. The genomic sequence and comparative analysis of the rat major histocompatibility complex. Hurt P, etal., Genome Res 2004 Apr;14(4):631-9.
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12477932   PMID:15489334  


Genomics

Comparative Map Data
G4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8203,698,359 - 3,701,036 (-)NCBIGRCr8
mRatBN7.2203,693,691 - 3,696,194 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl203,693,649 - 3,696,088 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx204,392,867 - 4,395,193 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0203,754,924 - 3,757,250 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0204,292,702 - 4,295,027 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0205,118,006 - 5,120,332 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl205,118,002 - 5,120,332 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0207,191,210 - 7,193,591 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4203,757,345 - 3,759,671 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1203,758,257 - 3,759,139 (-)NCBI
Celera204,329,625 - 4,331,951 (+)NCBICelera
Cytogenetic Map20p12NCBI
C6orf47
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38631,658,298 - 31,660,778 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl631,658,298 - 31,660,778 (-)EnsemblGRCh38hg38GRCh38
GRCh37631,626,075 - 31,628,555 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36631,734,054 - 31,736,528 (-)NCBINCBI36Build 36hg18NCBI36
Build 34631,734,053 - 31,736,528NCBI
Celera633,224,296 - 33,226,770 (-)NCBICelera
Cytogenetic Map6p21.33NCBI
HuRef631,412,300 - 31,414,774 (-)NCBIHuRef
CHM1_1631,628,211 - 31,630,685 (-)NCBICHM1_1
T2T-CHM13v2.0631,511,331 - 31,513,811 (-)NCBIT2T-CHM13v2.0
D17H6S53E
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391735,345,378 - 35,347,831 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1735,345,349 - 35,347,831 (+)EnsemblGRCm39 Ensembl
GRCm381735,126,402 - 35,128,855 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1735,126,373 - 35,128,855 (+)EnsemblGRCm38mm10GRCm38
MGSCv371735,264,060 - 35,264,941 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361734,735,171 - 34,736,052 (+)NCBIMGSCv36mm8
Celera1738,224,049 - 38,224,930 (+)NCBICelera
Cytogenetic Map17B1NCBI
cM Map1718.59NCBI
LOC102018324
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955437193,514 - 194,392 (-)EnsemblChiLan1.0
ChiLan1.0NW_004955437192,873 - 195,159 (-)NCBIChiLan1.0ChiLan1.0
C5H6orf47
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2546,135,357 - 46,138,979 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1642,096,875 - 42,100,496 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0631,319,493 - 31,322,681 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1632,209,368 - 32,211,819 (-)NCBIpanpan1.1PanPan1.1panPan2
C12H6orf47
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1121,142,457 - 1,144,929 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl121,143,216 - 1,144,079 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha121,278,625 - 1,281,110 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0121,287,418 - 1,289,903 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl121,287,854 - 1,289,865 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1121,146,767 - 1,149,253 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0121,214,031 - 1,216,516 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0121,281,098 - 1,283,584 (-)NCBIUU_Cfam_GSD_1.0
CUNH6orf47
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494635,692,687 - 35,694,655 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049367271,867,052 - 1,867,933 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049367271,866,681 - 1,868,645 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
C7H6orf47
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1723,773,897 - 23,775,346 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2727,476,616 - 27,478,065 (+)NCBISscrofa10.2Sscrofa10.2susScr3
CUNH6orf47
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Vero_WHO_p1.0NW_02366604431,569,176 - 31,572,335 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
CUNH6orf47
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462475424,552,352 - 24,554,596 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in G4
19 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:282
Count of miRNA genes:173
Interacting mature miRNAs:195
Transcripts:ENSRNOT00000060819
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
61472Aia1Adjuvant induced arthritis QTL 1180.001joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)2026463954597031Rat
2306850Pia40Pristane induced arthritis QTL 400.0001joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)2015279595304575Rat
1641915Colcr9Colorectal carcinoma resistance QTL 92.970.0024intestine integrity trait (VT:0010554)benign colorectal tumor number (CMO:0001795)20153065546530655Rat
2317057Aia27Adjuvant induced arthritis QTL 272.83joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)20289259726381954Rat
7387283Uae44Urinary albumin excretion QTL 440.1712urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)20126123605Rat
7411668Foco32Food consumption QTL 3280.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)20136600972Rat
2305926Iddm37Insulin dependent diabetes mellitus QTL 376blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)20152784246527842Rat
1354642Despr15Despair related QTL 150.0027locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)20124159021Rat
1600382Edcs3Endometrial carcinoma susceptibility QTL33.50.003uterus morphology trait (VT:0001120)percentage of study population developing endometrioid carcinoma during a period of time (CMO:0001759)20125159026Rat
61448Ciaa1CIA Autoantibody QTL 1300.001blood autoantibody amount (VT:0003725)calculated serum anti-rat type 2 collagen autoantibody titer (CMO:0001281)2026463954597031Rat
1331772Cdexp2CD45RC expression in CD8 T cells QTL 25.7CD8-positive T cell quantity (VT:0008077)blood CD45RC(high) CD8 T cell count to CD45RC(low) CD8 T cell count ratio (CMO:0001990)20362164910078919Rat
8694189Bw153Body weight QTL 1533.130.001body mass (VT:0001259)body weight gain (CMO:0000420)20129191651Rat
1300152Bp195Blood pressure QTL 1953.46arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2036216499243559Rat
9590109Sffal8Serum free fatty acids level QTL 85.320.01blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)20129191651Rat
9590275Scort15Serum corticosterone level QTL 153.480.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)20129191651Rat
9589155Insul32Insulin level QTL 326.380.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)20129191651Rat
7411650Foco23Food consumption QTL 2320.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)20129191651Rat
2317851Alcrsp22Alcohol response QTL 223.20.05response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)20127339237Rat
1598816Memor12Memory QTL 122.4exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)20260683647606836Rat
61432Cia1Collagen induced arthritis QTL 1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)20362165614101050Rat
1641893Alcrsp7Alcohol response QTL 7response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)20127339237Rat
6893685Bw111Body weight QTL 1112.70.004body mass (VT:0001259)body weight (CMO:0000012)20132578807Rat
9590252Scort12Serum corticosterone level QTL 1220.460.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)20136600972Rat
737973Pia21Pristane induced arthritis QTL 214.8joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)2036216564606812Rat

Markers in Region
RH132137  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2203,697,727 - 3,697,924 (-)MAPPERmRatBN7.2
Rnor_6.0205,116,099 - 5,116,295NCBIRnor6.0
Rnor_5.0207,189,358 - 7,189,554UniSTSRnor5.0
RGSC_v3.4203,761,382 - 3,761,578UniSTSRGSC3.4
Celera204,327,718 - 4,327,914UniSTS
RH 3.4 Map2051.2UniSTS
Cytogenetic Map20p12UniSTS
RH142043  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2203,693,748 - 3,693,954 (-)MAPPERmRatBN7.2
Rnor_6.0205,120,069 - 5,120,274NCBIRnor6.0
Rnor_5.0207,193,328 - 7,193,533UniSTSRnor5.0
RGSC_v3.4203,757,403 - 3,757,608UniSTSRGSC3.4
Celera204,331,688 - 4,331,893UniSTS
RH 3.4 Map2051.3UniSTS
Cytogenetic Map20p12UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000060819   ⟹   ENSRNOP00000057545
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl203,693,653 - 3,696,088 (-)Ensembl
Rnor_6.0 Ensembl205,118,026 - 5,120,332 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000076270
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl205,118,025 - 5,118,683 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000077032
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl205,118,002 - 5,118,621 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000117404   ⟹   ENSRNOP00000091132
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl203,693,649 - 3,696,088 (-)Ensembl
RefSeq Acc Id: NM_001003975   ⟹   NP_001003975
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8203,698,359 - 3,700,685 (-)NCBI
mRatBN7.2203,693,691 - 3,696,017 (-)NCBI
Rnor_6.0205,118,006 - 5,120,332 (+)NCBI
Rnor_5.0207,191,210 - 7,193,591 (+)NCBI
RGSC_v3.4203,757,345 - 3,759,671 (-)RGD
Celera204,329,625 - 4,331,951 (+)RGD
Sequence:
RefSeq Acc Id: XM_063279383   ⟹   XP_063135453
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8203,698,366 - 3,701,036 (-)NCBI
RefSeq Acc Id: NP_001003975   ⟸   NM_001003975
- UniProtKB: Q3T1L1 (UniProtKB/Swiss-Prot),   Q6MG51 (UniProtKB/Swiss-Prot),   A6KTU8 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000057545   ⟸   ENSRNOT00000060819
Ensembl Acc Id: ENSRNOP00000091132   ⟸   ENSRNOT00000117404
RefSeq Acc Id: XP_063135453   ⟸   XM_063279383
- Peptide Label: isoform X1
- UniProtKB: Q6MG51 (UniProtKB/Swiss-Prot),   Q3T1L1 (UniProtKB/Swiss-Prot),   A6KTU8 (UniProtKB/TrEMBL)

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q6MG51-F1-model_v2 AlphaFold Q6MG51 1-293 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13701394
Promoter ID:EPDNEW_R11918
Type:initiation region
Name:G4_1
Description:G4 protein
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0205,118,041 - 5,118,101EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1303038 AgrOrtholog
BioCyc Gene G2FUF-4648 BioCyc
Ensembl Genes ENSRNOG00000039658 Ensembl, UniProtKB/Swiss-Prot
  ENSRNOG00055006929 UniProtKB/Swiss-Prot
  ENSRNOG00060005399 UniProtKB/Swiss-Prot
  ENSRNOG00065033049 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000060819.5 UniProtKB/Swiss-Prot
  ENSRNOT00000117404.1 UniProtKB/Swiss-Prot
  ENSRNOT00055011416 UniProtKB/Swiss-Prot
  ENSRNOT00055011419 UniProtKB/Swiss-Prot
  ENSRNOT00060008964 UniProtKB/Swiss-Prot
  ENSRNOT00060008970 UniProtKB/Swiss-Prot
  ENSRNOT00065056863 UniProtKB/Swiss-Prot
  ENSRNOT00065056869 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7937508 IMAGE-MGC_LOAD
InterPro DUF4661 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:406868 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE MGC:124525 IMAGE-MGC_LOAD
NCBI Gene 406868 ENTREZGENE
PANTHER C6ORF47 FAMILY MEMBER UniProtKB/TrEMBL, UniProtKB/Swiss-Prot
  SI:CH73-25F10.6 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam DUF4661 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen G4 PhenoGen
RatGTEx ENSRNOG00000039658 RatGTEx
  ENSRNOG00055006929 RatGTEx
  ENSRNOG00060005399 RatGTEx
  ENSRNOG00065033049 RatGTEx
UniProt A6KTU8 ENTREZGENE, UniProtKB/TrEMBL
  CF047_RAT UniProtKB/Swiss-Prot
  Q3T1L1 ENTREZGENE
  Q6MG51 ENTREZGENE
UniProt Secondary Q3T1L1 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2005-02-14 G4  G4 protein      Symbol and Name status set to provisional 70820 PROVISIONAL