Zfp365 (zinc finger protein 365) - Rat Genome Database

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Gene: Zfp365 (zinc finger protein 365) Rattus norvegicus
Analyze
Symbol: Zfp365
Name: zinc finger protein 365
RGD ID: 1565986
Description: Predicted to enable metal ion binding activity. Involved in positive regulation of oligodendrocyte differentiation. Predicted to be located in centrosome and cytoplasm. Human ortholog(s) of this gene implicated in uric acid nephrolithiasis. Orthologous to human ZNF365 (zinc finger protein 365); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; acetamide; acrylamide.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: Znf365
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82020,665,122 - 20,688,607 (+)NCBIGRCr8
mRatBN7.22020,666,240 - 20,689,734 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2020,666,240 - 20,691,238 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2021,395,013 - 21,418,499 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02020,747,627 - 20,771,114 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02021,222,748 - 21,246,240 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02022,060,160 - 22,083,766 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2022,060,224 - 22,086,108 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02024,159,323 - 24,183,062 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42021,490,528 - 21,514,845 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera2022,029,753 - 22,053,277 (+)NCBICelera
Cytogenetic Map20p11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
COVID-19  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
centrosome  (IEA)
cytoplasm  (IEA)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. A novel DISC1-interacting partner DISC1-Binding Zinc-finger protein: implication in the modulation of DISC1-dependent neurite outgrowth. Hattori T, etal., Mol Psychiatry. 2007 Apr;12(4):398-407. Epub 2007 Jan 23.
3. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
4. GOA pipeline RGD automated data pipeline
5. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
6. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
7. DBZ, a CNS-specific DISC1 binding protein, positively regulates oligodendrocyte differentiation. Shimizu S, etal., Glia. 2014 May;62(5):709-24. doi: 10.1002/glia.22636. Epub 2014 Jan 30.
8. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
Additional References at PubMed
PMID:15489334   PMID:16617106   PMID:23776040   PMID:23912123   PMID:23966166   PMID:25983680  


Genomics

Comparative Map Data
Zfp365
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82020,665,122 - 20,688,607 (+)NCBIGRCr8
mRatBN7.22020,666,240 - 20,689,734 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2020,666,240 - 20,691,238 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2021,395,013 - 21,418,499 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02020,747,627 - 20,771,114 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02021,222,748 - 21,246,240 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02022,060,160 - 22,083,766 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2022,060,224 - 22,086,108 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02024,159,323 - 24,183,062 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42021,490,528 - 21,514,845 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera2022,029,753 - 22,053,277 (+)NCBICelera
Cytogenetic Map20p11NCBI
ZNF365
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381062,643,643 - 62,672,010 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1062,520,448 - 62,672,011 (+)EnsemblGRCh38hg38GRCh38
GRCh371064,134,128 - 64,240,044 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361063,803,922 - 64,101,777 (+)NCBINCBI36Build 36hg18NCBI36
Celera1057,401,050 - 57,698,970 (+)NCBICelera
Cytogenetic Map10q21.2NCBI
HuRef1058,125,768 - 58,423,451 (+)NCBIHuRef
CHM1_11064,416,070 - 64,713,897 (+)NCBICHM1_1
T2T-CHM13v2.01063,501,484 - 63,529,831 (+)NCBIT2T-CHM13v2.0
Zfp365
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391067,721,935 - 67,748,492 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1067,721,933 - 67,748,492 (-)EnsemblGRCm39 Ensembl
GRCm381067,886,105 - 67,912,662 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1067,886,103 - 67,912,662 (-)EnsemblGRCm38mm10GRCm38
MGSCv371067,348,853 - 67,375,410 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361067,281,462 - 67,308,019 (-)NCBIMGSCv36mm8
MGSCv361067,936,422 - 67,962,516 (-)NCBIMGSCv36mm8
Celera1068,980,055 - 69,006,641 (-)NCBICelera
Cytogenetic Map10B5.1NCBI
cM Map1035.04NCBI
Znf365
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542515,652,373 - 15,675,336 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495542515,652,373 - 15,675,255 (+)NCBIChiLan1.0ChiLan1.0
ZNF365
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2874,572,996 - 74,601,063 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11074,578,319 - 74,606,386 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01058,894,939 - 58,923,176 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11061,223,925 - 61,329,657 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1061,223,925 - 61,329,657 (+)Ensemblpanpan1.1panPan2
ZNF365
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1414,297,652 - 14,429,634 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl414,311,302 - 14,331,568 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha414,527,088 - 14,642,551 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0414,573,032 - 14,689,126 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl414,573,096 - 14,687,863 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1414,556,021 - 14,671,742 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0414,681,301 - 14,796,777 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0415,036,427 - 15,152,301 (+)NCBIUU_Cfam_GSD_1.0
Znf365
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440721366,746,717 - 66,767,306 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936614835,866 - 853,547 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936614833,665 - 853,547 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ZNF365
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1465,861,564 - 65,888,335 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11465,861,398 - 65,888,341 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21470,935,090 - 70,959,967 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ZNF365
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1968,872,683 - 68,900,911 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl968,871,827 - 68,900,724 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604829,755,750 - 29,783,958 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Znf365
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247911,330,794 - 1,470,973 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247911,330,869 - 1,355,248 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Zfp365
151 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:366
Count of miRNA genes:218
Interacting mature miRNAs:272
Transcripts:ENSRNOT00000057992
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1354642Despr15Despair related QTL 150.0027locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)20124159021Rat
1600382Edcs3Endometrial carcinoma susceptibility QTL33.50.003uterus morphology trait (VT:0001120)percentage of study population developing endometrioid carcinoma during a period of time (CMO:0001759)20125159026Rat
2317851Alcrsp22Alcohol response QTL 223.20.05response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)20127339237Rat
1641893Alcrsp7Alcohol response QTL 7response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)20127339237Rat
8694189Bw153Body weight QTL 1533.130.001body mass (VT:0001259)body weight gain (CMO:0000420)20129191651Rat
9590275Scort15Serum corticosterone level QTL 153.480.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)20129191651Rat
7411650Foco23Food consumption QTL 2320.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)20129191651Rat
9590109Sffal8Serum free fatty acids level QTL 85.320.01blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)20129191651Rat
9589155Insul32Insulin level QTL 326.380.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)20129191651Rat
6893685Bw111Body weight QTL 1112.70.004body mass (VT:0001259)body weight (CMO:0000012)20132578807Rat
7411668Foco32Food consumption QTL 3280.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)20136600972Rat
9590252Scort12Serum corticosterone level QTL 1220.460.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)20136600972Rat
2305926Iddm37Insulin dependent diabetes mellitus QTL 376blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)20152784246527842Rat
1641915Colcr9Colorectal carcinoma resistance QTL 92.970.0024intestine integrity trait (VT:0010554)benign colorectal tumor number (CMO:0001795)20153065546530655Rat
1598816Memor12Memory QTL 122.4exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)20260683647606836Rat
2317057Aia27Adjuvant induced arthritis QTL 272.83joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)20289259726381954Rat
4889870Pur30Proteinuria QTL 30190.005urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)20804241029322208Rat
7411652Foco24Food consumption QTL 240.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)201175751554435887Rat
9590092Insglur9Insulin/glucose ratio QTL 918.380.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)201175751554435887Rat
4889610Pancm3Pancreatic morphology QTL 33.750.001pancreas mass (VT:0010144)pancreas wet weight (CMO:0000626)201761783247606836Rat
2317880Alcrsp25Alcohol response QTL 252.3response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)201769755054435887Rat
2303626Vencon10Ventilatory control QTL 100.001respiration trait (VT:0001943)respiration rate (CMO:0000289)201919072154435887Rat

Markers in Region
D20Got116  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22020,678,571 - 20,678,700 (+)MAPPERmRatBN7.2
Rnor_6.02022,072,670 - 22,072,796NCBIRnor6.0
Rnor_5.02024,171,833 - 24,171,959UniSTSRnor5.0
RGSC_v3.42021,502,443 - 21,502,569UniSTSRGSC3.4
Celera2022,042,035 - 22,042,161UniSTS
Cytogenetic Map20p11UniSTS
RH137818  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22020,689,514 - 20,689,685 (+)MAPPERmRatBN7.2
Rnor_6.02022,083,547 - 22,083,717NCBIRnor6.0
Rnor_5.02024,182,843 - 24,183,013UniSTSRnor5.0
RGSC_v3.42021,514,626 - 21,514,796UniSTSRGSC3.4
Celera2022,053,058 - 22,053,228UniSTS
Cytogenetic Map20p11UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 31 4 10
Low 3 41 26 10 19 10 8 11 43 35 36 1 8
Below cutoff 2 31 31 31 1

Sequence


RefSeq Acc Id: ENSRNOT00000057992   ⟹   ENSRNOP00000054802
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2020,666,322 - 20,691,238 (+)Ensembl
Rnor_6.0 Ensembl2022,060,224 - 22,086,108 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000119323   ⟹   ENSRNOP00000092825
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2020,666,240 - 20,688,379 (+)Ensembl
RefSeq Acc Id: NM_001025145   ⟹   NP_001020316
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82020,665,122 - 20,688,607 (+)NCBI
mRatBN7.22020,666,240 - 20,689,734 (+)NCBI
Rnor_6.02022,060,160 - 22,083,766 (+)NCBI
Rnor_5.02024,159,323 - 24,183,062 (+)NCBI
RGSC_v3.42021,490,528 - 21,514,845 (+)RGD
Celera2022,029,753 - 22,053,277 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001020316 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH87056 (Get FASTA)   NCBI Sequence Viewer  
  EDL97318 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000054802
  ENSRNOP00000054802.4
  ENSRNOP00000092825.1
GenBank Protein Q5PQS2 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_001020316   ⟸   NM_001025145
- UniProtKB: Q5PQS2 (UniProtKB/Swiss-Prot),   A6JKV2 (UniProtKB/TrEMBL),   A0A8L2QRR1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000054802   ⟸   ENSRNOT00000057992
RefSeq Acc Id: ENSRNOP00000092825   ⟸   ENSRNOT00000119323

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q5PQS2-F1-model_v2 AlphaFold Q5PQS2 1-408 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13701561
Promoter ID:EPDNEW_R12084
Type:initiation region
Name:Zfp365_1
Description:zinc finger protein 365
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.02022,060,227 - 22,060,287EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1565986 AgrOrtholog
BioCyc Gene G2FUF-3888 BioCyc
Ensembl Genes ENSRNOG00000000638 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000057992 ENTREZGENE
  ENSRNOT00000057992.5 UniProtKB/TrEMBL
  ENSRNOT00000119323.1 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7124000 IMAGE-MGC_LOAD
KEGG Report rno:499425 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE MGC:94069 IMAGE-MGC_LOAD
NCBI Gene 499425 ENTREZGENE
PANTHER PROTEIN ZNF365 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ZINC FINGER PROTEIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Zfp365 PhenoGen
RatGTEx ENSRNOG00000000638 RatGTEx
UniProt A0A8I6AGA7_RAT UniProtKB/TrEMBL
  A0A8L2QRR1 ENTREZGENE, UniProtKB/TrEMBL
  A6JKV2 ENTREZGENE, UniProtKB/TrEMBL
  Q5PQS2 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2006-02-09 Zfp365  zinc finger protein 365      Symbol and Name status set to provisional 70820 PROVISIONAL