Slc25a16 (solute carrier family 25 member 16)

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Gene: Slc25a16 (solute carrier family 25 member 16) Rattus norvegicus

Analyze

Symbol:

Slc25a16 (Ensembl: Dna2)

Name:

solute carrier family 25 member 16 (Ensembl:DNA replication helicase/nuclease 2)

RGD ID:

1311311

Description:

Predicted to enable coenzyme A transmembrane transporter activity. Predicted to be involved in mitochondrial coenzyme A transmembrane transport. Predicted to be located in mitochondrion. Predicted to be part of gamma DNA polymerase complex. Predicted to be active in mitochondrial inner membrane. Orthologous to human SLC25A16 (solute carrier family 25 member 16); INTERACTS WITH (+)-schisandrin B; acetamide; acrylamide.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

GDC; graves disease carrier protein; LOC361836; mitochondrial solute carrier protein homolog; solute carrier family 25 (mitochondrial carrier), member 16; solute carrier family 25 (mitochondrial carrier, Graves disease autoantigen), member 16; solute carrier family 25, member 16

RGD Orthologs

Human

Mouse

Chinchilla

Dog

Squirrel

Pig

Green Monkey

Naked Mole-Rat

Alliance Genes

More Info

more info ...

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	20	25,661,158 - 25,717,558 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	20	25,662,055 - 25,716,319 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	20	26,385,022 - 26,409,844 (-)	NCBI	Rnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0	20	25,738,050 - 25,762,873 (-)	NCBI	Rnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0	20	26,324,094 - 26,348,852 (-)	NCBI	Rnor_WKY
Rnor_6.0	20	27,283,383 - 27,308,069 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	20	27,254,984 - 27,308,069 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	20	29,124,026 - 29,147,931 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	20	25,259,020 - 25,287,344 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	20	25,272,066 - 25,299,061 (+)	NCBI
Celera	20	26,987,115 - 27,012,429 (-)	NCBI		Celera
Cytogenetic Map	20	q11	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Cerebral Visual Impairment and Intellectual Disability (ISO)

genetic disease (ISO)

nonsyndromic congenital nail disorder (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(+)-schisandrin B (EXP)

(1->4)-beta-D-glucan (ISO)

2,3,7,8-tetrachlorodibenzodioxine (ISO)

2-hydroxypropanoic acid (ISO)

4,4'-sulfonyldiphenol (ISO)

acetamide (EXP)

acrylamide (EXP)

ammonium chloride (EXP)

amphetamine (EXP)

arsenite(3-) (ISO)

benzo[a]pyrene (ISO)

benzo[a]pyrene diol epoxide I (ISO)

bisphenol A (EXP,ISO)

carbon nanotube (ISO)

ciguatoxin CTX1B (ISO)

copper(II) sulfate (ISO)

cyclosporin A (ISO)

dorsomorphin (ISO)

elemental selenium (ISO)

epoxiconazole (ISO)

formaldehyde (ISO)

glafenine (EXP)

hydrogen peroxide (ISO)

isotretinoin (ISO)

lead diacetate (EXP)

methapyrilene (EXP)

methidathion (ISO)

methyl methanesulfonate (ISO)

panobinostat (ISO)

paracetamol (EXP,ISO)

perfluorooctane-1-sulfonic acid (ISO)

phenobarbital (ISO)

phenylmercury acetate (ISO)

progesterone (ISO)

quercetin (ISO)

rac-lactic acid (ISO)

SB 431542 (ISO)

selenium atom (ISO)

sunitinib (ISO)

tert-butyl hydroperoxide (ISO)

testosterone (ISO)

testosterone enanthate (ISO)

tetrachloromethane (EXP,ISO)

thapsigargin (ISO)

valproic acid (ISO)

vancomycin (ISO)

vitamin E (ISO)

vorinostat (ISO)

zidovudine (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

base-excision repair (IEA)

DNA double-strand break processing (IEA)

DNA duplex unwinding (IEA)

DNA repair (IEA)

DNA replication checkpoint signaling (IEA)

DNA replication, Okazaki fragment processing (IEA)

DNA replication, removal of RNA primer (IEA)

mitochondrial coenzyme A transmembrane transport (IBA)

mitochondrial DNA repair (IEA)

mitochondrial DNA replication (IEA)

positive regulation of DNA replication (IEA)

transmembrane transport (IEA)

Cellular Component

gamma DNA polymerase complex (IEA)

mitochondrial inner membrane (IBA,IEA)

mitochondrial nucleoid (IEA)

mitochondrion (ISO)

nucleoplasm (IEA)

nucleus (IEA)

Molecular Function

4 iron, 4 sulfur cluster binding (IEA)

5'-3' DNA helicase activity (IEA)

5'-flap endonuclease activity (IEA)

ATP binding (IEA)

ATP hydrolysis activity (IEA)

coenzyme A transmembrane transporter activity (IBA)

DNA binding (IEA)

metal ion binding (IEA)

single-stranded DNA helicase activity (IEA)

site-specific endodeoxyribonuclease activity, specific for altered base (IEA)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Rat ISS GO annotations from GOA human gene data--August 2006	GOA data from the GO Consortium
3.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
4.	GOA pipeline	RGD automated data pipeline
5.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:2575220	PMID:12477932	PMID:14651853	PMID:18614015

Genomics

Comparative Map Data

Slc25a16
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	20	25,661,158 - 25,717,558 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	20	25,662,055 - 25,716,319 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	20	26,385,022 - 26,409,844 (-)	NCBI	Rnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0	20	25,738,050 - 25,762,873 (-)	NCBI	Rnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0	20	26,324,094 - 26,348,852 (-)	NCBI	Rnor_WKY
Rnor_6.0	20	27,283,383 - 27,308,069 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	20	27,254,984 - 27,308,069 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	20	29,124,026 - 29,147,931 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	20	25,259,020 - 25,287,344 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	20	25,272,066 - 25,299,061 (+)	NCBI
Celera	20	26,987,115 - 27,012,429 (-)	NCBI		Celera
Cytogenetic Map	20	q11	NCBI

SLC25A16
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	10	68,477,998 - 68,527,523 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p13 Ensembl	10	68,477,998 - 68,527,523 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	10	70,237,755 - 70,287,280 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	10	69,912,103 - 69,957,590 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	10	69,912,103 - 69,957,590	NCBI
Celera	10	63,517,479 - 63,563,049 (-)	NCBI		Celera
Cytogenetic Map	10	q21.3	NCBI
HuRef	10	64,241,842 - 64,288,560 (-)	NCBI		HuRef
CHM1_1	10	70,524,338 - 70,569,332 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	10	69,347,236 - 69,396,739 (-)	NCBI		T2T-CHM13v2.0

Slc25a16
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	10	62,756,454 - 62,782,278 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	10	62,756,412 - 62,782,277 (+)	Ensembl		GRCm39 Ensembl
GRCm38	10	62,920,632 - 62,946,494 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	10	62,920,633 - 62,946,498 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	10	62,383,381 - 62,409,242 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	10	62,315,990 - 62,341,851 (+)	NCBI		MGSCv36	mm8
Celera	10	64,021,749 - 64,047,627 (+)	NCBI		Celera
Cytogenetic Map	10	B4	NCBI

Slc25a16
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955425	20,707,006 - 20,739,455 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955425	20,705,758 - 20,739,692 (-)	NCBI	ChiLan1.0	ChiLan1.0

SLC25A16
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	4	19,695,305 - 19,738,832 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	4	19,697,034 - 19,738,834 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	4	19,826,297 - 19,870,093 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	4	19,966,484 - 20,010,542 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	4	19,967,641 - 20,010,559 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	4	19,868,192 - 19,911,728 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	4	20,071,276 - 20,114,631 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	4	20,413,440 - 20,457,128 (-)	NCBI		UU_Cfam_GSD_1.0

Slc25a16
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024407213	61,300,357 - 61,340,497 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936521	9,793,038 - 9,834,973 (+)	Ensembl	SpeTri2.0
SpeTri2.0	NW_004936521	9,793,088 - 9,834,972 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

SLC25A16
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	14	71,610,475 - 71,651,102 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	14	71,612,273 - 71,651,341 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	14	77,648,575 - 77,715,804 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

SLC25A16
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	9	62,871,828 - 62,926,759 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
Vero_WHO_p1.0	NW_023666048	23,629,311 - 23,675,003 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Slc25a16
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624754	2,800,350 - 2,837,918 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624754	2,800,432 - 2,837,910 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Slc25a16
73 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	546
Count of miRNA genes:	254
Interacting mature miRNAs:	300
Transcripts:	ENSRNOT00000056047
Prediction methods:	Microtar, Miranda
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
2317851	Alcrsp22	Alcohol response QTL 22	3.2	0.05	response to alcohol trait (VT:0010489)	duration of loss of righting reflex (CMO:0002289)	20	1	27339237	Rat
1641893	Alcrsp7	Alcohol response QTL 7			response to alcohol trait (VT:0010489)	duration of loss of righting reflex (CMO:0002289)	20	1	27339237	Rat
8694189	Bw153	Body weight QTL 153	3.13	0.001	body mass (VT:0001259)	body weight gain (CMO:0000420)	20	1	29191651	Rat
9590275	Scort15	Serum corticosterone level QTL 15	3.48	0.001	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	20	1	29191651	Rat
7411650	Foco23	Food consumption QTL 23	20.7	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	20	1	29191651	Rat
9590109	Sffal8	Serum free fatty acids level QTL 8	5.32	0.01	blood free fatty acid amount (VT:0001553)	plasma free fatty acids level (CMO:0000546)	20	1	29191651	Rat
9589155	Insul32	Insulin level QTL 32	6.38	0.001	blood insulin amount (VT:0001560)	plasma insulin level (CMO:0000342)	20	1	29191651	Rat
6893685	Bw111	Body weight QTL 111	2.7	0.004	body mass (VT:0001259)	body weight (CMO:0000012)	20	1	32578807	Rat
7411668	Foco32	Food consumption QTL 32	8	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	20	1	36600972	Rat
9590252	Scort12	Serum corticosterone level QTL 12	20.46	0.001	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	20	1	36600972	Rat
2305926	Iddm37	Insulin dependent diabetes mellitus QTL 37	6		blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	20	1527842	46527842	Rat
1641915	Colcr9	Colorectal carcinoma resistance QTL 9	2.97	0.0024	intestine integrity trait (VT:0010554)	benign colorectal tumor number (CMO:0001795)	20	1530655	46530655	Rat
1598816	Memor12	Memory QTL 12	2.4		exploratory behavior trait (VT:0010471)	average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)	20	2606836	47606836	Rat
2317057	Aia27	Adjuvant induced arthritis QTL 27	2.83		joint integrity trait (VT:0010548)	right rear ankle joint diameter (CMO:0002150)	20	2892597	26381954	Rat
4889870	Pur30	Proteinuria QTL 30	19	0.005	urine total protein amount (VT:0000032)	urine total protein excretion rate (CMO:0000756)	20	8042410	29322208	Rat
7411652	Foco24	Food consumption QTL 24		0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	20	11757515	54435887	Rat
9590092	Insglur9	Insulin/glucose ratio QTL 9	18.38	0.001	blood insulin amount (VT:0001560)	calculated plasma insulin level (CMO:0002170)	20	11757515	54435887	Rat
4889610	Pancm3	Pancreatic morphology QTL 3	3.75	0.001	pancreas mass (VT:0010144)	pancreas wet weight (CMO:0000626)	20	17617832	47606836	Rat
2317880	Alcrsp25	Alcohol response QTL 25	2.3		response to alcohol trait (VT:0010489)	duration of loss of righting reflex (CMO:0002289)	20	17697550	54435887	Rat
2303626	Vencon10	Ventilatory control QTL 10		0.001	respiration trait (VT:0001943)	respiration rate (CMO:0000289)	20	19190721	54435887	Rat
2303578	Gluco50	Glucose level QTL 50	2		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	20	25106722	54435887	Rat
2303587	Bw93	Body weight QTL 93	13		body mass (VT:0001259)	body weight (CMO:0000012)	20	25106722	54435887	Rat
2300188	Bmd68	Bone mineral density QTL 68	6.4	0.0001	femur mineral mass (VT:0010011)	volumetric bone mineral density (CMO:0001553)	20	25106722	54435887	Rat
1331747	Hrtrt16	Heart rate QTL 16	3.163		heart pumping trait (VT:2000009)	heart rate (CMO:0000002)	20	25209734	54435887	Rat

Markers in Region

RH128448

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	20	25,692,082 - 25,692,283 (+)	MAPPER	mRatBN7.2
Rnor_6.0	20	27,283,901 - 27,284,101	NCBI	Rnor6.0
Rnor_5.0	20	29,124,544 - 29,124,744	UniSTS	Rnor5.0
RGSC_v3.4	20	25,286,626 - 25,286,826	UniSTS	RGSC3.4
Celera	20	26,987,633 - 26,987,833	UniSTS
Cytogenetic Map	20	p11	UniSTS

AU047875

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	20	25,716,823 - 25,717,042 (+)	MAPPER	mRatBN7.2
Rnor_6.0	20	27,308,574 - 27,308,792	NCBI	Rnor6.0
Rnor_5.0	20	29,148,436 - 29,148,654	UniSTS	Rnor5.0
RGSC_v3.4	20	25,258,297 - 25,258,515	UniSTS	RGSC3.4
Celera	20	27,012,934 - 27,013,152	UniSTS
Cytogenetic Map	20	p11	UniSTS

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium	3	12	37	23	19	23			66	29	32	11
Low		31	20	18		18	8	11	8	6	9		8
Below cutoff

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001100860	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039098860	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039098861	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039098862	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039098863	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039098864	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	BC166494	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473988	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JACYVU010000324	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	M32973	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Reference Sequences

RefSeq Acc Id:

ENSRNOT00000000438 ⟹ ENSRNOP00000000438

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	20	25,663,299 - 25,716,319 (-)	Ensembl
Rnor_6.0 Ensembl	20	27,254,984 - 27,301,952 (-)	Ensembl

RefSeq Acc Id:

ENSRNOT00000056047 ⟹ ENSRNOP00000052899

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	20	25,691,567 - 25,716,319 (-)	Ensembl
Rnor_6.0 Ensembl	20	27,283,385 - 27,308,069 (-)	Ensembl

RefSeq Acc Id:

ENSRNOT00000102171 ⟹ ENSRNOP00000077473

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	20	25,663,299 - 25,707,418 (-)	Ensembl

RefSeq Acc Id:

ENSRNOT00000103093 ⟹ ENSRNOP00000083522

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	20	25,662,055 - 25,690,593 (-)	Ensembl

RefSeq Acc Id:

NM_001100860 ⟹ NP_001094330

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	20	25,691,565 - 25,716,319 (-)	NCBI
Rnor_6.0	20	27,283,383 - 27,308,069 (-)	NCBI
Rnor_5.0	20	29,124,026 - 29,147,931 (-)	NCBI
RGSC_v3.4	20	25,259,020 - 25,287,344 (+)	RGD
Celera	20	26,987,115 - 27,012,429 (-)	RGD

Sequence:

show sequence

AACAGCCATGGTGCTTCCTAGTGTTTTGTAAGTTGGCAGCGGAGGCTCGGGACGTGGCGCAGGT
CCGGATGGCGGCCCTGGTGGCTGCAGCGGCCCTGGCGGCGGCCGAGCCTCCACCCGCGGTGCCG
CAGGCGGCGGGGAGCGGGGGCCCGACCTCTCGCCGAGACTTCTACTGGCTGCGTTCCTTCTTAG
CCGGAGGTATTGCTGGATGCTGTGCCAAAACCACAGTTGCTCCCTTGGATCGAGTAAAGGTTTT
ATTACAAGCTCACAACCACCATTACAAACATTTAGGGGTACTTTCTGCACTGCGCGCTGTTCCC
CAAAAGGAAGGCTACCTTGGATTATATAAAGGAAACGGTGCAATGATGATTCGAATCTTTCCCT
ACGGTGCAATCCAGTTCATGGCCTTTGAGCATTATAAAACGTTCATTACTACAAAGCTGGGAGT
TTCTGGTCATGTGCATAGATTAATGGCTGGATCCATGGCAGGCATGACAGCAGTTATCTGCACT
TACCCTCTGGATGTGGTCAGGGTGCGCCTGGCCTTCCAAGTGAAAGGTGAACACACCTATTCAG
GGATCATCCATGCGTTCAAGACAATCTATGCCAAGGAAGGTGGTTTCCTTGGATTCTACAGAGG
TCTGATGCCTACTATATTAGGAATGGCTCCATATGCAGGTGTTTCCTTTTTTACCTTTGGTACC
TTGAAGAGTGTTGGGCTTTCCTATGCTCCCACCCTGCTTGGCCGACCATCGTCCGACAACCCCA
ACGTCTTAGTCTTGAAAACTCACATAAACTTACTTTGTGGTGGTGTTGCTGGAGCAATAGCACA
GACGATATCCTACCCATTTGATGTAACCCGTCGGAGAATGCAGTTGGGGGCAGTCCTACCGGAG
TTTGAGAAGTGCCTTACCATGAGGGAGACCATGAAGTATGTCTATGGACACCATGGGATTCGGA
GAGGATTGTACCGTGGCTTATCTCTGAACTACATCCGCTGTATTCCCTCTCAAGCTGTGGCTTT
CACAACATATGAACTTATGAAGCAATTTTTTCACCTTAACTAAAAGAAAAAAATCATGATTTGT
AGTTACTGTGCTCAGTAATTCTCGGAAGGATGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTGTG
TGTGTGTGTGTGTGTGTGTGTATGAGTGACACCTTAATTGTGAGGGAAACGTTACTTGAAGGGG
ACGTTTGCCCTCACACAGGAACCACTGGTATTTTAATACTTGATTTCTTTCAGTTTTTAAATCA
TAGATCAAAAATGCTTAGCATAATTTGTTATTTTTCTTTTTGATGGGATCTCCATATGTTATCC
TGGCTGGCTTGGAACTCACTGTGAAGAGACCAGGCTACCCTCAGACTTGTAGCAATCCTCTTTC
CTCTGCTGCCCATTCCAGAGAATTGGAATCCCATGCCTGAGATTCCAGGCGTCAGCCATCATGC
TTCCTCTGACATACTTTTTAATGGCAAACATTATACCTTAAAACCCTGAAGAGCCATCTTGGGC
TGACTGTGGCTACCTGTTTGGTTATTTTAAAGTGTTAATAGGAAGGAAAAGAAAGTTCATATTT
GAGTTCAAGAGATTGTCATTAGTCCTACCATACCATTCCAAACTTCCCATTGTAACTGTGGTTA
CTGGGGGCGGAGGGACTGGAATCCAACCGAGGGCCTTTGCATGCCAAGCACATGTTGTACCCCC
TCACCACATCCCCAGCCTGCAAGCACCATAGCACTGAGCTATGTCACTGGCCCTTTTCTGTTTT
ATTGTGAAGCTGGGGATGGATCACACTCATGCATGACGATTGTGTAATTGCACACTGCCAATGG
CCCACACCCCCAGCCAACTAACCCCGCTCCTTATTTACCCCCTCCCACTCTGTCCTTTCTTTAC
TTCTTCTGGGGAGTAAACTCAGGGTCTCTCTTGCCTATCTTGCTAGATAAGTGCTCTACCTCTG
AACTACATCTCCAGCCTTTTAGCCTTGGGTAATGTTATTAAAATCAGCCGACTTCGTTTTATTG
TCGCAGAATGAGGACTGAATATTTAAGGTCTGTGAAACAGAGCCAGCAACAAAGTAGTGTTCTT
ATTATGTTTCACCTCATAATTCTGCTCCAGTTGATAAAAACAACACCTTTCCCTTCATTCGTTT
GAAAAGCAGACTGTCTGCCTGCCTGCCTGCCTTTCTTTCTTCCTTCCTTCCTTCCTTCCTTCCT
TCCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTCTTTCTTTCTTTCTTT
CTTCTCTCTTTGGGGATTGAATCTAGGACCAGGCATGATGAGATCCCATCAGAAAACCAAGTGT
ACACTGAGGTACATCCCCAAATGTCTTTCACTCTCAATAAAATTAGTGCTGAATTTTAAAGGAG
ATATTCAAGAAATGAAGAAATAGCAGGTCTTGTTCAAATGCTGTTATCATGGACTTTGATTTTC
ATGAGTTTTTTAAAAGCCTGTGTTTCCCAAAGGCAGTGATAATAAAAACTAAATATCTTTGCTC
TTAAAAGGAGAGTAACATTGTAGATGCTTGTCTTAAATAACTTGGTATGTACTAGAAAATTTAA
ATGGACCATAAATTTAGATGAAGCAATGTTTCCGAGGTATTATGTCAAGATATAAAGTTCTTCC
ATGTAATGTAAGTTTAGTGTGTCATAGTCCTAAGCGTAAATATAAAACACGTTGCAATTGTTAC
ATTTTAAAGAGATTGTTTAGTATATAAAAATTCTAATCATTGTGTTTAGAACACTTTTCTCTTT
TGTTGTAAGCATGACACATGAAGTAGAAGCAGTAAACTGTCTTTAGAGGTAGTGATTTGTAGAA
TTGATGTGATTTTTAAGACATTAAAATTAAGCTGCAAATGTTATTTCTGCATTTTTTCATGTAT
GATTTCTTGTCATAGCTTGAAAAATTGGATGAATCAGTTTCATTTTTATAATCTTTACTTTAAA
AATAAAAATGTATCTTGTGATTTGTAAATGTACCAGGAGTGGGGATAAAGTCTGTTTATAATGT
AAAGCTCTTTTGTATATTTTAATTTCTGGACCACACTGTAGCTAGTTATTCCATTTAATCTTAA
GGTAATTTAAATCTATAAAATAAATATCTCAATTATATTATCAAAAAAAAAAAAAAAAAAAAAA
AAAA

hide sequence

RefSeq Acc Id:

XM_039098860 ⟹ XP_038954788

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	20	25,663,430 - 25,693,682 (-)	NCBI

RefSeq Acc Id:

XM_039098861 ⟹ XP_038954789

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	20	25,661,158 - 25,688,127 (-)	NCBI

RefSeq Acc Id:

XM_039098862 ⟹ XP_038954790

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	20	25,661,158 - 25,681,675 (-)	NCBI

RefSeq Acc Id:

XM_039098863 ⟹ XP_038954791

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	20	25,661,158 - 25,682,381 (-)	NCBI

RefSeq Acc Id:

XM_039098864 ⟹ XP_038954792

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	20	25,691,474 - 25,717,558 (-)	NCBI

Protein Sequences


Protein RefSeqs	NP_001094330	(Get FASTA)	NCBI Sequence Viewer
	XP_038954788	(Get FASTA)	NCBI Sequence Viewer
	XP_038954789	(Get FASTA)	NCBI Sequence Viewer
	XP_038954790	(Get FASTA)	NCBI Sequence Viewer
	XP_038954791	(Get FASTA)	NCBI Sequence Viewer
	XP_038954792	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAA41639	(Get FASTA)	NCBI Sequence Viewer
	AAI66494	(Get FASTA)	NCBI Sequence Viewer
	EDL97370	(Get FASTA)	NCBI Sequence Viewer
	EDL97371	(Get FASTA)	NCBI Sequence Viewer
	P16261	(Get FASTA)	NCBI Sequence Viewer

Reference Sequences

RefSeq Acc Id:

NP_001094330 ⟸ NM_001100860

- UniProtKB:

B2GV20 (UniProtKB/TrEMBL), F1MA22 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MAALVAAAALAAAEPPPAVPQAAGSGGPTSRRDFYWLRSFLAGGIAGCCAKTTVAPLDRVKVLL
QAHNHHYKHLGVLSALRAVPQKEGYLGLYKGNGAMMIRIFPYGAIQFMAFEHYKTFITTKLGVS
GHVHRLMAGSMAGMTAVICTYPLDVVRVRLAFQVKGEHTYSGIIHAFKTIYAKEGGFLGFYRGL
MPTILGMAPYAGVSFFTFGTLKSVGLSYAPTLLGRPSSDNPNVLVLKTHINLLCGGVAGAIAQT
ISYPFDVTRRRMQLGAVLPEFEKCLTMRETMKYVYGHHGIRRGLYRGLSLNYIRCIPSQAVAFT
TYELMKQFFHLN

hide sequence

RefSeq Acc Id:

ENSRNOP00000000438 ⟸ ENSRNOT00000000438

RefSeq Acc Id:

ENSRNOP00000052899 ⟸ ENSRNOT00000056047

RefSeq Acc Id:	XP_038954789 ⟸ XM_039098861
- Peptide Label:	isoform X2

RefSeq Acc Id:	XP_038954791 ⟸ XM_039098863
- Peptide Label:	isoform X4

RefSeq Acc Id:	XP_038954790 ⟸ XM_039098862
- Peptide Label:	isoform X3

RefSeq Acc Id:	XP_038954788 ⟸ XM_039098860
- Peptide Label:	isoform X1

RefSeq Acc Id:	XP_038954792 ⟸ XM_039098864
- Peptide Label:	isoform X5

RefSeq Acc Id:

ENSRNOP00000077473 ⟸ ENSRNOT00000102171

RefSeq Acc Id:

ENSRNOP00000083522 ⟸ ENSRNOT00000103093

Protein Domains

DNA replication factor Dna2 N-terminal DNA2/NAM7 helicase helicase DNA2/NAM7 helicase-like C-terminal

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-P16261-F1-model_v2	AlphaFold	P16261	1-322	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13701572

Promoter ID:

EPDNEW_R12096

Type:

initiation region

Name:

Slc25a16_1

Description:

solute carrier family 25 member 16

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	20	27,308,078 - 27,308,138	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1311311	AgrOrtholog
BioCyc Gene	G2FUF-3808	BioCyc
Ensembl Genes	ENSRNOG00000000387	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein	ENSRNOP00000000438.6	UniProtKB/TrEMBL
	ENSRNOP00000052899	ENTREZGENE
	ENSRNOP00000052899.4	UniProtKB/TrEMBL
	ENSRNOP00000077473.1	UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000000438.8	UniProtKB/TrEMBL
	ENSRNOT00000056047	ENTREZGENE
	ENSRNOT00000056047.4	UniProtKB/TrEMBL
	ENSRNOT00000102171.1	UniProtKB/TrEMBL
Gene3D-CATH	1.50.40.10	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	2.40.30.270	UniProtKB/TrEMBL
	3.40.50.300	UniProtKB/TrEMBL
	3.90.320.10	UniProtKB/TrEMBL
IMAGE_CLONE	IMAGE:7110872	IMAGE-MGC_LOAD
InterPro	Dna2	UniProtKB/TrEMBL
	DNA2/NAM7-like	UniProtKB/TrEMBL
	DNA2/NAM7-like_C	UniProtKB/TrEMBL
	DNA2/NAM7_AAA_11	UniProtKB/TrEMBL
	DNA_replication_fac_Dna2_N	UniProtKB/TrEMBL
	Graves_DC	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Mit_carrier	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Mitochondrial_sb/sol_carrier	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Mt_carrier_dom_sf	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	P-loop_NTPase	UniProtKB/TrEMBL
	PDDEXK-like_dom_sf	UniProtKB/TrEMBL
	SF1_C_Upf1	UniProtKB/TrEMBL
KEGG Report	rno:361836	UniProtKB/TrEMBL
MGC_CLONE	MGC:188021	IMAGE-MGC_LOAD
NCBI Gene	361836	ENTREZGENE
PANTHER	GRAVES DISEASE CARRIER PROTEIN	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	PTHR10887	UniProtKB/TrEMBL
	PTHR10887:SF433	UniProtKB/TrEMBL
	SOLUTE CARRIER FAMILY 25	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam	AAA_11	UniProtKB/TrEMBL
	AAA_12	UniProtKB/TrEMBL
	Dna2	UniProtKB/TrEMBL
	Mito_carr	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen	Slc25a16	PhenoGen
PRINTS	GRAVESDC	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	MITOCARRIER	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE	SOLCAR	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP	SSF103506	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	SSF52540	UniProtKB/TrEMBL
UniProt	A0A0H2UH92_RAT	UniProtKB/TrEMBL
	A0A8I5Y1L7_RAT	UniProtKB/TrEMBL
	B2GV20	ENTREZGENE, UniProtKB/TrEMBL
	F1MA22	ENTREZGENE
	GDC_RAT	UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary	F1MA22	UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2016-06-15	Slc25a16	solute carrier family 25 member 16	Slc25a16	solute carrier family 25 (mitochondrial carrier), member 16	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2014-06-25	Slc25a16	solute carrier family 25 (mitochondrial carrier), member 16	Slc25a16	solute carrier family 25 (mitochondrial carrier, Graves disease autoantigen), member 16	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2005-12-06	Slc25a16	solute carrier family 25 (mitochondrial carrier, Graves disease autoantigen), member 16	Slc25a16_predicted	solute carrier family 25 (mitochondrial carrier, Graves disease autoantigen), member 16 (predicted)	Symbol and Name updated	1559027	APPROVED
2005-01-12	Slc25a16_predicted	solute carrier family 25 (mitochondrial carrier, Graves disease autoantigen), member 16 (predicted)			Symbol and Name status set to approved	70820	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - ClinVar