Mif (macrophage migration inhibitory factor) - Rat Genome Database

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Gene: Mif (macrophage migration inhibitory factor) Rattus norvegicus
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Symbol: Mif
Name: macrophage migration inhibitory factor
RGD ID: 621163
Description: Predicted to enable several functions, including identical protein binding activity; intramolecular oxidoreductase activity; and receptor ligand activity. Involved in several processes, including positive regulation of transport; response to steroid hormone; and response to vitamin. Located in cytoplasm; extracellular space; and nucleus. Used to study several diseases, including acute necrotizing pancreatitis; cardiomyopathy (multiple); lung disease (multiple); retinitis; and toxic shock syndrome. Biomarker of borna disease; cystitis; kidney disease; myocardial infarction; and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in allergic disease; asthma; cystic fibrosis; lung disease (multiple); and obesity. Orthologous to human MIF (macrophage migration inhibitory factor); PARTICIPATES IN alkaptonuria pathway; disulfiram pharmacodynamics pathway; dopamine beta-hydroxylase deficiency pathway; INTERACTS WITH 1,2,4-trimethylbenzene; 17alpha-ethynylestradiol; 17beta-estradiol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: glutathione-binding 13 kDa protein; L-dopachrome isomerase; L-dopachrome tautomerase; LOC103694877; macrophage migration inhibitory factor (glycosylation-inhibiting factor); MGC72801; phenylpyruvate tautomerase
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Related Pseudogenes: LOC120102174   Mif-ps1  
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.22012,790,919 - 12,791,784 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2012,790,902 - 12,799,504 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2013,497,160 - 13,498,025 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.02012,858,083 - 12,858,948 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.02013,330,028 - 13,330,893 (+)NCBIRnor_WKY
Rnor_6.02013,715,219 - 13,732,980 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2013,732,198 - 13,732,859 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02015,885,248 - 15,886,113 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42013,191,986 - 13,192,851 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12013,192,212 - 13,193,078 (+)NCBI
Celera2014,283,080 - 14,283,945 (+)NCBICelera
Cytogenetic Map20p12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
acute necrotizing pancreatitis  (IDA)
agammaglobulinemia 2  (ISO)
Alcoholic Liver Diseases  (IEP)
allergic disease  (ISO)
Animal Mammary Neoplasms  (ISO)
anti-basement membrane glomerulonephritis  (IDA)
anxiety disorder  (ISO)
arteriosclerosis  (ISO)
asthma  (IDA,ISO)
autism spectrum disorder  (ISO)
autistic disorder  (ISO)
borna disease  (IEP)
Brain Injuries  (IEP)
Breast Neoplasms  (ISO)
Bronchial Hyperreactivity  (ISO)
Bronchopulmonary Dysplasia  (ISO)
Burns  (IEP)
carcinoma  (ISO)
cardiomyopathy  (IDA)
Chylothorax  (ISO)
colitis  (IDA,ISO)
Coronary Disease  (IEP)
cystic fibrosis  (ISO)
cystitis  (IEP)
Disease Progression  (ISO)
Endotoxemia  (IEP)
epilepsy  (IDA,ISO)
Experimental Arthritis  (IDA)
Experimental Colitis  (ISO)
Experimental Diabetes Mellitus  (ISO)
Experimental Liver Cirrhosis  (IEP)
Experimental Mammary Neoplasms  (ISO)
Granuloma  (IEP)
Hamartoma  (ISO)
Hypercholesterolemia  (IEP)
hypertension  (IDA)
Inflammation  (IDA,ISO)
Insulin Resistance  (ISO)
Keloid  (ISO)
kidney disease  (IEP)
lung disease  (IMP,ISO)
lung non-small cell carcinoma  (ISO)
malignant mesothelioma  (ISO)
Memory Disorders  (ISO)
mental depression  (ISO)
myocardial infarction  (IEP,ISO)
myocarditis  (IDA)
newborn respiratory distress syndrome  (ISO)
obesity  (ISO)
pneumonia  (ISO)
Prostatic Neoplasms  (ISO)
pulmonary edema  (ISO)
pulmonary hypertension  (ISO)
pulmonary tuberculosis  (ISO)
Radiation Pneumonitis  (ISO)
Reperfusion Injury  (ISO)
retinitis  (IDA)
rheumatoid arthritis  (ISO)
rhinitis  (ISO)
schizophrenia  (ISO)
Sepsis  (ISO)
Spinal Cord Injuries  (IEP)
Stevens-Johnson syndrome  (ISO)
Stroke  (IEP,ISO)
Systemic Juvenile Rheumatoid Arthritis  (ISO)
toxic shock syndrome  (IDA,IMP)
type 2 diabetes mellitus  (IEP)
viral pneumonia  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-artemisinic acid  (ISO)
(+)-catechin  (ISO)
(Z)-3-butylidenephthalide  (ISO)
1,10-phenanthroline  (ISO)
1,2,4-trimethylbenzene  (EXP)
1-fluoro-2,4-dinitrobenzene  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2,4,6-trinitrotoluene  (EXP)
2-amino-14,16-dimethyloctadecan-3-ol  (ISO)
3-phenylprop-2-enal  (ISO)
3H-1,2-dithiole-3-thione  (EXP)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-chloro-7-iodoquinolin-8-ol  (ISO)
7,12-dimethyltetraphene  (EXP)
acetamide  (EXP)
acrylamide  (EXP)
all-trans-retinoic acid  (ISO)
ammonium chloride  (EXP)
amphibole asbestos  (ISO)
anthra[1,9-cd]pyrazol-6(2H)-one  (ISO)
antirheumatic drug  (ISO)
apocynin  (ISO)
aristolochic acid  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
asbestos  (ISO)
asperentin  (ISO)
atrazine  (EXP)
azoxystrobin  (EXP)
benzalkonium chloride  (ISO)
benzatropine  (ISO)
benzo[a]pyrene  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bisphenol A  (EXP,ISO)
bleomycin A2  (EXP)
bromobenzene  (EXP)
buspirone  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (EXP)
caffeine  (ISO)
capsaicin  (EXP)
carbamazepine  (ISO)
carbon nanotube  (ISO)
cerium trichloride  (ISO)
CGP 52608  (ISO)
chlorohydrocarbon  (EXP)
chloropicrin  (ISO)
chlorothalonil  (ISO)
chlorpyrifos  (EXP)
chromium(6+)  (ISO)
clofibric acid  (EXP)
cobalt atom  (ISO)
cobalt dichloride  (ISO)
cobalt(2+) sulfate  (ISO)
copper(II) sulfate  (ISO)
cumene  (ISO)
cyclophosphamide  (EXP)
dexamethasone  (ISO)
dextran sulfate  (ISO)
diarsenic trioxide  (ISO)
diazinon  (ISO)
dibutyl phthalate  (EXP)
dinitrogen  (ISO)
dioxygen  (ISO)
doxorubicin  (EXP,ISO)
enzyme inhibitor  (ISO)
epoxiconazole  (ISO)
ethanol  (EXP)
finasteride  (EXP)
flavonoids  (ISO)
fluoxetine  (EXP)
flutamide  (EXP)
folic acid  (ISO)
formaldehyde  (ISO)
gentamycin  (EXP)
glyphosate  (EXP)
heparin  (ISO)
hydrogen chloride  (EXP)
hydrogen peroxide  (ISO)
hydrogen sulfide  (ISO)
imidacloprid  (EXP)
iron atom  (EXP)
iron(0)  (EXP)
ivermectin  (ISO)
kojic acid  (EXP)
L-methionine  (ISO)
lipopolysaccharide  (ISO)
metam  (ISO)
methamphetamine  (EXP)
methidathion  (ISO)
methylmercury chloride  (EXP)
mono(2-ethylhexyl) phthalate  (ISO)
mycophenolic acid  (ISO)
mycotoxin  (ISO)
N-nitrosodiethylamine  (EXP)
naphthalenes  (EXP)
naproxen  (EXP)
nefazodone  (EXP)
nickel atom  (EXP)
nickel sulfate  (ISO)
nitrofen  (EXP)
ochratoxin A  (EXP)
oleanolic acid  (ISO)
ozone  (ISO)
paracetamol  (EXP)
paraquat  (ISO)
phenobarbital  (EXP)
PhIP  (EXP)
phorbol 13-acetate 12-myristate  (ISO)
pirinixic acid  (ISO)
pregnenolone 16alpha-carbonitrile  (EXP)
pyrogallol  (ISO)
quercetin  (ISO)
resveratrol  (EXP)
rottlerin  (ISO)
sarin  (EXP)
SB 431542  (ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenite  (ISO)
sterigmatocystin  (ISO)
sumatriptan  (EXP)
tanespimycin  (ISO)
temozolomide  (ISO)
tetrachloroethene  (ISO)
thiabendazole  (EXP)
titanium dioxide  (ISO)
trichostatin A  (ISO)
trimellitic anhydride  (ISO)
tungsten  (EXP,ISO)
Tungsten carbide  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
vorinostat  (ISO)
zinc dichloride  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
aging  (IEP)
brain development  (IEP)
brain renin-angiotensin system  (IMP)
carboxylic acid metabolic process  (ISO)
cell surface receptor signaling pathway  (ISO)
cellular response to hydrogen peroxide  (IEP)
cellular response to hypoxia  (IEP)
cellular senescence  (ISO)
DNA damage response, signal transduction by p53 class mediator  (ISO)
drinking behavior  (IMP)
hair follicle development  (IEP)
inflammatory response  (IEA)
innate immune response  (IEA)
negative regulation of apoptotic process  (ISO)
negative regulation of cell migration  (ISO)
negative regulation of cellular senescence  (ISO)
negative regulation of DNA damage response, signal transduction by p53 class mediator  (ISO)
negative regulation of gene expression  (ISO)
negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator  (ISO)
negative regulation of macrophage chemotaxis  (ISO)
negative regulation of mature B cell apoptotic process  (ISO)
negative regulation of myeloid cell apoptotic process  (ISO)
negative regulation of protein metabolic process  (ISO)
obsolete cell aging  (ISO)
obsolete negative regulation of cell aging  (ISO)
positive chemotaxis  (IEA)
positive regulation of acute inflammatory response  (IMP)
positive regulation of arachidonic acid secretion  (ISO)
positive regulation of axon regeneration  (IMP)
positive regulation of B cell proliferation  (ISO)
positive regulation of cell population proliferation  (ISO)
positive regulation of chemokine (C-X-C motif) ligand 2 production  (ISO)
positive regulation of cytokine production  (ISO)
positive regulation of ERK1 and ERK2 cascade  (ISO)
positive regulation of fibroblast proliferation  (ISO)
positive regulation of glucose import  (IMP)
positive regulation of glycolytic process  (IMP)
positive regulation of immune response  (IMP)
positive regulation of lipopolysaccharide-mediated signaling pathway  (ISO)
positive regulation of MAP kinase activity  (ISO)
positive regulation of myeloid leukocyte cytokine production involved in immune response  (ISO)
positive regulation of peptidyl-serine phosphorylation  (ISO)
positive regulation of peptidyl-tyrosine phosphorylation  (ISO)
positive regulation of phosphorylation  (ISO)
positive regulation of potassium ion transport  (IMP)
positive regulation of prostaglandin secretion involved in immune response  (ISO)
positive regulation of protein kinase A signaling  (ISO)
positive regulation of protein phosphorylation  (ISO)
positive regulation of smooth muscle cell migration  (IMP)
positive regulation of tumor necrosis factor production  (ISO)
prostaglandin biosynthetic process  (ISO)
protein homotrimerization  (ISO)
regulation of cell population proliferation  (ISO)
response to estradiol  (IEP)
response to glucocorticoid  (IEP)
response to heat  (IEP)
response to hormone  (IEP)
response to inorganic substance  (IEP)
response to insulin  (IEP)
response to lipopolysaccharide  (IEP)
response to mechanical stimulus  (IEP)
response to menaquinone  (IEP)
response to progesterone  (IEP)
response to vitamin E  (IEP)
response to xenobiotic stimulus  (IEP)
skin development  (IEP)
spermatogenesis  (IMP)
wound healing  (IEP)

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. The role of macrophage migration inhibitory factor in the cascade of events leading to reperfusion-induced inflammatory injury and lethality. Amaral FA, etal., Am J Pathol. 2007 Dec;171(6):1887-93. Epub 2007 Nov 30.
2. Borna disease virus-induced accumulation of macrophage migration inhibitory factor in rat brain astrocytes is associated with inhibition of macrophage infiltration. Bacher M, etal., Glia. 2002 Mar 15;37(4):291-306.
3. Macrophage migration inhibitory factor may contribute to vasculopathy in systemic sclerosis. Becker H, etal., Clin Rheumatol. 2008 Oct;27(10):1307-11. Epub 2008 Jul 11.
4. The proinflammatory mediator macrophage migration inhibitory factor induces glucose catabolism in muscle. Benigni F, etal., J Clin Invest. 2000 Nov;106(10):1291-300.
5. MIF is a noncognate ligand of CXC chemokine receptors in inflammatory and atherogenic cell recruitment. Bernhagen J, etal., Nat Med. 2007 May;13(5):587-96. Epub 2007 Apr 15.
6. Prolactin-modulated gene expression profiles in pancreatic islets from adult female rats. Bordin S, etal., Mol Cell Endocrinol. 2004 May 31;220(1-2):41-50.
7. Proteomic identification of macrophage migration-inhibitory factor upon exposure to TiO2 particles. Cha MH, etal., Mol Cell Proteomics. 2007 Jan;6(1):56-63. Epub 2006 Oct 6.
8. Endotoxin-induced myocardial dysfunction: effects of macrophage migration inhibitory factor neutralization. Chagnon F, etal., Circ Res. 2005 May 27;96(10):1095-102. Epub 2005 May 5.
9. Proinflammatory macrophage migratory inhibition factor and interleukin-6 are concentrated in pleural effusion of human fetuses with prenatal chylothorax. Chen M, etal., Prenat Diagn. 2007 May;27(5):435-41.
10. Critical role of macrophage migration inhibitory factor activity in experimental autoimmune diabetes. Cvetkovic I, etal., Endocrinology. 2005 Jul;146(7):2942-51. Epub 2005 Mar 24.
11. Increased plasma concentration of macrophage migration inhibitory factor (MIF) and MIF mRNA in mononuclear cells in the obese and the suppressive action of metformin. Dandona P, etal., J Clin Endocrinol Metab. 2004 Oct;89(10):5043-7.
12. Influence of macrophage migration inhibitory factor (MIF) on the zinc content and redox state of protein-bound sulphydryl groups in rat sperm: indications for a new role of MIF in sperm maturation. Eickhoff R, etal., Mol Hum Reprod. 2004 Aug;10(8):605-11. Epub 2004 May 28.
13. Cardiovascular protective role for activated protein C during endotoxemia in rats. Favory R, etal., Intensive Care Med. 2006 Jun;32(6):899-905. Epub 2006 Apr 7.
14. Regulation of macrophage migration inhibitory factor expression by glucocorticoids in vivo. Fingerle-Rowson G, etal., Am J Pathol 2003 Jan;162(1):47-56.
15. Polymorphisms of the macrophage inhibitory factor and C-reactive protein genes in subjects with Alzheimer's dementia. Flex A, etal., Dement Geriatr Cogn Disord. 2004;18(3-4):261-4. Epub 2004 Jul 29.
16. Contribution of macrophage migration inhibitory factor to extracellular signal-regulated kinase activation by oxidative stress in cardiomyocytes. Fukuzawa J, etal., J Biol Chem 2002 Jul 12;277(28):24889-95.
17. Macrophage migration inhibitory factor in acute lung injury: expression, biomarker, and associations. Gao L, etal., Transl Res. 2007 Jul;150(1):18-29. Epub 2007 May 25.
18. Estrogen-inducible uterine flavonoid binding sites: is it time to reconsider? Garai J and Adlercreutz H, J Steroid Biochem Mol Biol. 2004 Apr;88(4-5):377-81.
19. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
20. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
21. Spironolactone prevents diabetic nephropathy through an anti-inflammatory mechanism in type 2 diabetic rats. Han SY, etal., J Am Soc Nephrol. 2006 May;17(5):1362-72. Epub 2006 Mar 29.
22. Redox regulation of macrophage migration inhibitory factor expression in rat neurons. Harrison RA and Sumners C, Biochem Biophys Res Commun. 2009 Dec 4;390(1):171-5. Epub 2009 Sep 30.
23. Genetic variants in inflammation-related genes are associated with radiation-induced toxicity following treatment for non-small cell lung cancer. Hildebrandt MA, etal., PLoS One. 2010 Aug 25;5(8):e12402.
24. Functional polymorphisms in the promoter region of macrophage migration inhibitory factor and atopy. Hizawa N, etal., Am J Respir Crit Care Med. 2004 May 1;169(9):1014-8. Epub 2004 Feb 12.
25. Immunohistochemical study of macrophage migration inhibitory factor in rat liver fibrosis induced by thioacetamide. Hori Y, etal., Eur J Histochem. 2003;47(4):317-24.
26. Role of macrophage migration inhibitory factor in influenza H5N1 virus pneumonia. Hou XQ, etal., Acta Virol. 2009;53(4):225-31.
27. Sex steroid regulation of macrophage migration inhibitory factor in normal and inflamed colon in the female rat. Houdeau E, etal., Gastroenterology. 2007 Mar;132(3):982-93. Epub 2006 Dec 17.
28. Downregulation of migration inhibitory factor is critical for estrogen-mediated attenuation of lung tissue damage following trauma-hemorrhage. Hsieh YC, etal., Am J Physiol Lung Cell Mol Physiol. 2007 May;292(5):L1227-32. Epub 2007 Feb 2.
29. [Effect of hypoxia on the expression of macrophage migration inhibitory factor (MIF) in rat vascular smooth muscle cells]. Hu XL, etal., Sichuan Da Xue Xue Bao Yi Xue Ban. 2009 Mar;40(2):260-2, 267.
30. Insulin attenuates the systemic inflammatory response to thermal trauma. Jeschke MG, etal., Mol Med. 2002 Aug;8(8):443-50.
31. The -173 G/C polymorphism of the promoter region macrophage migration inhibitory factor gene is not associated with incidence of pulmonary hamartoma. Kaznowska E, etal., Pol J Pathol. 2007;58(3):189-92.
32. A role for macrophage migration inhibitory factor in the neonatal respiratory distress syndrome. Kevill KA, etal., J Immunol. 2008 Jan 1;180(1):601-8.
33. Involvement of macrophage migration inhibitory factor (MIF) in experimental uric acid nephropathy. Kim YG, etal., Mol Med. 2000 Oct;6(10):837-48.
34. Inhibition of experimental autoimmune uveoretinitis with anti-macrophage migration inhibitory factor antibodies. Kitaichi N, etal., Curr Eye Res. 2000 Feb;20(2):109-14.
35. Differences in the hepatic signal transcription pathway and cytokine expression between thermal injury and sepsis. Klein D, etal., Shock. 2003 Dec;20(6):536-43.
36. Role of macrophage migration inhibitory factor in ovalbumin-induced airway inflammation in rats. Kobayashi M, etal., Eur Respir J. 2006 Apr;27(4):726-34. Epub 2006 Feb 2.
37. Up-regulation of macrophage migration-inhibitory factor expression after compression-induced spinal cord injury in rats. Koda M, etal., Acta Neuropathol (Berl). 2004 Jul;108(1):31-6. Epub 2004 Apr 6.
38. Regulation of macrophage migration inhibitory factor by endogenous glucocorticoids in rat adjuvant-induced arthritis. Leech M, etal., Arthritis Rheum. 2000 Apr;43(4):827-33.
39. Macrophage migration inhibitory factor in the PVN attenuates the central pressor and dipsogenic actions of angiotensin II. Li H, etal., FASEB J. 2006 Aug;20(10):1748-50. Epub 2006 Jun 29.
40. [Myocardial inflammation and injury induced by coronary microembolization in rats: role of ERK1/2 signaling pathway]. Li L, etal., Zhonghua Yi Xue Za Zhi. 2010 Mar 2;90(8):558-63.
41. Uncaria rhynchophylla upregulates the expression of MIF and cyclophilin A in kainic acid-induced epilepsy rats: A proteomic analysis. Lo WY, etal., Am J Chin Med. 2010;38(4):745-59.
42. Macrophage migration inhibitory factor is essential for allergic asthma but not for Th2 differentiation. Magalhaes ES, etal., Eur J Immunol. 2007 Apr;37(4):1097-106.
43. Effect of anti-macrophage migration inhibitory factor antibody on lipopolysaccharide-induced pulmonary neutrophil accumulation. Makita H, etal., Am J Respir Crit Care Med. 1998 Aug;158(2):573-9.
44. Role of macrophage migration inhibitory factor in acute lung injury in mice with acute pancreatitis complicated by endotoxemia. Matsuda N, etal., Am J Respir Cell Mol Biol. 2006 Aug;35(2):198-205. Epub 2006 Mar 30.
45. Blockade of macrophage migration inhibitory factor ameliorates experimental autoimmune myocarditis. Matsui Y, etal., J Mol Cell Cardiol. 2004 Aug;37(2):557-66.
46. Macrophage migration inhibitory factor increases neuronal delayed rectifier K+ current. Matsuura T, etal., J Neurophysiol. 2006 Feb;95(2):1042-8. Epub 2005 Nov 2.
47. Macrophage migration inhibitory factor is upregulated in an endotoxin-induced model of bladder inflammation in rats. Meyer-Siegler KL, etal., J Interferon Cytokine Res. 2004 Jan;24(1):55-63.
48. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
49. Up-regulation of macrophage colony-stimulating factor (M-CSF) and migration inhibitory factor (MIF) expression and monocyte recruitment during lipid-induced glomerular injury in the exogenous hypercholesterolaemic (ExHC) rat. Miyazaki K, etal., Clin Exp Immunol. 1997 May;108(2):318-23.
50. Role for macrophage migration inhibitory factor in asthma. Mizue Y, etal., Proc Natl Acad Sci U S A. 2005 Oct 4;102(40):14410-5. Epub 2005 Sep 26.
51. Macrophage migration inhibitory factor in allergic rhinitis: its identification in eosinophils at the site of inflammation. Nakamaru Y, etal., Ann Otol Rhinol Laryngol. 2004 Mar;113(3 Pt 1):205-9.
52. Macrophage migration inhibitory factor (MIF) contributes to the development of allergic rhinitis. Nakamaru Y, etal., Cytokine. 2005 Jul 21;31(2):103-8.
53. Macrophage migration inhibitory factor expression in male and female ethanol-fed rats. Nanji AA, etal., J Interferon Cytokine Res. 2001 Dec;21(12):1055-62.
54. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
55. Role of macrophage migration inhibitory factor (MIF) in peripheral nerve regeneration: anti-MIF antibody induces delay of nerve regeneration and the apoptosis of Schwann cells. Nishio Y, etal., Mol Med. 2002 Sep;8(9):509-20.
56. Transgenic over-expression of macrophage migration inhibitory factor renders mice markedly more susceptible to experimental colitis. Ohkawara T, etal., Clin Exp Immunol. 2005 May;140(2):241-8. doi: 10.1111/j.1365-2249.2005.02771.x.
57. The potential role of macrophage migration inhibitory factor on the migration of vascular smooth muscle cells. Okamoto T, etal., J Atheroscler Thromb. 2008 Feb;15(1):13-9. Epub 2008 Feb 9.
58. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
59. Increased expression of macrophage migration inhibitory factor during fracture healing in rats. Onodera S, etal., Histochem Cell Biol. 2004 Mar;121(3):209-17. Epub 2004 Feb 6.
60. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
61. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
62. Cystic fibrosis, disease severity, and a macrophage migration inhibitory factor polymorphism. Plant BJ, etal., Am J Respir Crit Care Med. 2005 Dec 1;172(11):1412-5. Epub 2005 Sep 22.
63. GOA pipeline RGD automated data pipeline
64. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
65. Human circulating eosinophils secrete macrophage migration inhibitory factor (MIF). Potential role in asthma. Rossi AG, etal., J Clin Invest. 1998 Jun 15;101(12):2869-74.
66. Analysis of MIF, FCGR2A and FCGR3A gene polymorphisms with susceptibility to pulmonary tuberculosis in Moroccan population. Sadki K, etal., J Genet Genomics. 2010 Apr;37(4):257-64.
67. Macrophage migration inhibitory factor is a critical mediator of severe acute pancreatitis. Sakai Y, etal., Gastroenterology 2003 Mar;124(3):725-36.
68. Effect of vitamin E on production of macrophage migration inhibitory factor (MIF) by macrophages. Sakamoto W, etal., Biofactors. 1999;10(2-3):139-43.
69. The effect of vitamin K2 on bone metabolism in aged female rats. Sakamoto W, etal., Osteoporos Int. 2005 Dec;16(12):1604-10. Epub 2005 Apr 22.
70. Promoter polymorphism in the macrophage migration inhibitory factor gene is associated with obesity. Sakaue S, etal., Int J Obes (Lond). 2006 Feb;30(2):238-42.
71. Lung-derived macrophage migration inhibitory factor in sepsis induces cardio-circulatory depression. Sakuragi T, etal., Surg Infect (Larchmt). 2007 Feb;8(1):29-40.
72. Expression of macrophage migration inhibitory factor in rat skin during embryonic development. Shimizu T, etal., Exp Dermatol. 2005 Nov;14(11):819-23.
73. Comparison of cell-type-specific vs transmural aortic gene expression in experimental aneurysms. Sho E, etal., J Vasc Surg. 2005 May;41(5):844-52.
74. Lack of macrophage migration inhibitory factor regulation is linked to the increased chronotropic action of angiotensin II in SHR neurons. Sun C, etal., Hypertension. 2007 Mar;49(3):528-34. Epub 2007 Jan 29.
75. Augmented expression of macrophage migration inhibitory factor (MIF) in the telencephalon of the developing rat brain. Suzuki T, etal., Brain Res. 1999 Jan 23;816(2):457-62.
76. The effect of therapeutic hypothermia on the expression of inflammatory response genes following moderate traumatic brain injury in the rat. Truettner JS, etal., Brain Res Mol Brain Res. 2005 Aug 18;138(2):124-34.
77. Hydrochloric acid induced changes in macrophage migration inhibitory factor in the bladder, peripheral and central nervous system of the rat. Vera PL, etal., J Urol. 2003 Aug;170(2 Pt 1):623-7.
78. Macrophage migration inhibitory factor is released as a complex with alpha1-inhibitor-3 in the intraluminal fluid during bladder inflammation in the rat. Vera PL, etal., J Urol. 2005 Jul;174(1):338-43.
79. Cyclophosphamide-induced cystitis increases bladder CXCR4 expression and CXCR4-macrophage migration inhibitory factor association. Vera PL, etal., PLoS One. 2008;3(12):e3898. Epub 2008 Dec 10.
80. Plasma concentrations of macrophage migration inhibitory factor are elevated in Pima Indians compared to Caucasians and are associated with insulin resistance. Vozarova B, etal., Diabetologia. 2002 Dec;45(12):1739-41. Epub 2002 Nov 16.
81. [Role of macrophage migration inhibitory factor in septic shock-induced cardiovascular dysfunction: experiment with rats] Wang FZ, etal., Zhonghua Yi Xue Za Zhi. 2007 Mar 20;87(11):768-73.
82. Upregulation of macrophage migration inhibitory factor gene expression in stroke. Wang L, etal., Stroke. 2009 Mar;40(3):973-6. Epub 2009 Jan 8.
83. Macrophage migration inhibitory factor and CXC chemokine expression in non-small cell lung cancer: role in angiogenesis and prognosis. White ES, etal., Clin Cancer Res. 2003 Feb;9(2):853-60.
84. Association of MIF promoter polymorphisms with childhood asthma in a northeastern Chinese population. Wu J, etal., Tissue Antigens. 2009 Apr;73(4):302-6.
85. Reversal of established rat crescentic glomerulonephritis by blockade of macrophage migration inhibitory factor (MIF): potential role of MIF in regulating glucocorticoid production. Yang N, etal., Mol Med. 1998 Jun;4(6):413-24.
86. The influence of macrophage migration inhibitory factor gene polymorphisms on outcome from community-acquired pneumonia. Yende S, etal., FASEB J. 2009 Aug;23(8):2403-11. Epub 2009 Apr 3.
87. Elevation of plasma level of macrophage migration inhibitory factor in patients with acute myocardial infarction. Yu CM, etal., Am J Cardiol. 2001 Oct 1;88(7):774-7.
88. Expression of macrophage migration inhibitory factor in acute ischemic myocardial injury. Yu CM, etal., J Histochem Cytochem. 2003 May;51(5):625-31.
Additional References at PubMed
PMID:1436109   PMID:7951062   PMID:8605628   PMID:10364264   PMID:10562313   PMID:11756671   PMID:12297465   PMID:12477932   PMID:12631343   PMID:12782713   PMID:12878730   PMID:12908877  
PMID:15012733   PMID:15489334   PMID:15525779   PMID:15576460   PMID:15809768   PMID:15899155   PMID:16115025   PMID:16285950   PMID:16728343   PMID:16728344   PMID:16981995   PMID:17045821  
PMID:17526494   PMID:17634366   PMID:18056708   PMID:18235500   PMID:19056867   PMID:19155217   PMID:19190083   PMID:19394321   PMID:19602265   PMID:20458337   PMID:20534506   PMID:20883785  
PMID:21209875   PMID:21500553   PMID:21802455   PMID:21817065   PMID:21887805   PMID:22005047   PMID:22136975   PMID:22952837   PMID:23376485   PMID:23533145   PMID:24006456   PMID:24569872  
PMID:24667295   PMID:25416956   PMID:25647395   PMID:25701358   PMID:25705692   PMID:26318747   PMID:26847932   PMID:26929185   PMID:27068509   PMID:27926507   PMID:28158469   PMID:28161708  
PMID:28165114   PMID:28851074   PMID:29207187   PMID:29335619   PMID:29690804   PMID:29760351   PMID:30341520   PMID:30465176   PMID:30601408   PMID:31197516   PMID:31515488   PMID:31904090  
PMID:31960418   PMID:32357304   PMID:32964038   PMID:33994866   PMID:34242901   PMID:35395782  


Genomics

Comparative Map Data
Mif
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.22012,790,919 - 12,791,784 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2012,790,902 - 12,799,504 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2013,497,160 - 13,498,025 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.02012,858,083 - 12,858,948 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.02013,330,028 - 13,330,893 (+)NCBIRnor_WKY
Rnor_6.02013,715,219 - 13,732,980 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2013,732,198 - 13,732,859 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02015,885,248 - 15,886,113 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42013,191,986 - 13,192,851 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12013,192,212 - 13,193,078 (+)NCBI
Celera2014,283,080 - 14,283,945 (+)NCBICelera
Cytogenetic Map20p12NCBI
MIF
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382223,894,383 - 23,895,223 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl2223,894,383 - 23,895,227 (+)EnsemblGRCh38hg38GRCh38
GRCh372224,236,570 - 24,237,410 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362222,566,565 - 22,567,409 (+)NCBINCBI36Build 36hg18NCBI36
Build 342222,561,118 - 22,561,963NCBI
Celera228,074,325 - 8,075,169 (+)NCBICelera
Cytogenetic Map22q11.23NCBI
HuRef227,221,904 - 7,222,748 (+)NCBIHuRef
CHM1_12224,248,957 - 24,249,801 (+)NCBICHM1_1
T2T-CHM13v2.02224,338,982 - 24,339,822 (+)NCBIT2T-CHM13v2.0
Mif
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391075,695,187 - 75,696,111 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1075,695,187 - 75,696,074 (-)EnsemblGRCm39 Ensembl
GRCm381075,859,353 - 75,860,277 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1075,859,353 - 75,860,240 (-)EnsemblGRCm38mm10GRCm38
MGSCv371075,322,098 - 75,322,995 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361075,303,069 - 75,303,966 (-)NCBIMGSCv36mm8
Celera1076,904,043 - 76,904,940 (-)NCBICelera
Cytogenetic Map10C1NCBI
cM Map1038.59NCBI
Mif
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554558,367,566 - 8,368,460 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554558,367,566 - 8,368,460 (-)NCBIChiLan1.0ChiLan1.0
MIF
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.12222,729,245 - 22,732,009 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2222,730,807 - 22,732,009 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0224,646,986 - 4,647,831 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
MIF
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Dog10K_Boxer_Tasha2627,715,404 - 27,716,260 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02630,047,047 - 30,047,902 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2630,047,057 - 30,047,856 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12628,128,386 - 28,129,245 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02627,746,427 - 27,747,273 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02628,734,407 - 28,735,264 (-)NCBIUU_Cfam_GSD_1.0
Mif
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118141,546,059 - 141,547,004 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366191,203,746 - 1,208,442 (-)EnsemblSpeTri2.0
SpeTri2.0NW_0049366191,207,058 - 1,208,010 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MIF
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1449,840,305 - 49,841,068 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11449,840,303 - 49,841,063 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21453,282,553 - 53,283,313 (-)NCBISscrofa10.2Sscrofa10.2susScr3
MIF
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1197,000,837 - 7,001,700 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl197,000,793 - 7,001,757 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666100368,099 - 370,934 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Mif
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474710,303,919 - 10,308,821 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474710,307,826 - 10,308,649 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Mif
5 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:47
Count of miRNA genes:45
Interacting mature miRNAs:47
Transcripts:ENSRNOT00000008608
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1354642Despr15Despair related QTL 150.0027locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)20124159021Rat
1600382Edcs3Endometrial carcinoma susceptibility QTL33.50.003uterus morphology trait (VT:0001120)percentage of study population developing endometrioid carcinoma during a period of time (CMO:0001759)20125159026Rat
2317851Alcrsp22Alcohol response QTL 223.20.05response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)20127339237Rat
1641893Alcrsp7Alcohol response QTL 7response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)20127339237Rat
8694189Bw153Body weight QTL 1533.130.001body mass (VT:0001259)body weight gain (CMO:0000420)20129191651Rat
9590275Scort15Serum corticosterone level QTL 153.480.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)20129191651Rat
7411650Foco23Food consumption QTL 2320.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)20129191651Rat
9590109Sffal8Serum free fatty acids level QTL 85.320.01blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)20129191651Rat
9589155Insul32Insulin level QTL 326.380.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)20129191651Rat
6893685Bw111Body weight QTL 1112.70.004body mass (VT:0001259)body weight (CMO:0000012)20132578807Rat
7411668Foco32Food consumption QTL 3280.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)20136600972Rat
9590252Scort12Serum corticosterone level QTL 1220.460.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)20136600972Rat
2305926Iddm37Insulin dependent diabetes mellitus QTL 376blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)20152784246527842Rat
1641915Colcr9Colorectal carcinoma resistance QTL 92.970.0024intestine integrity trait (VT:0010554)benign colorectal tumor number (CMO:0001795)20153065546530655Rat
1598816Memor12Memory QTL 122.4exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)20260683647606836Rat
2317057Aia27Adjuvant induced arthritis QTL 272.83joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)20289259726381954Rat
61432Cia1Collagen induced arthritis QTL 1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)20362165614101050Rat
4889857Pur27Proteinuria QTL 2712.20.001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)20460660717617956Rat
1558640Prcs2Prostate cancer susceptibility QTL 23.3prostate integrity trait (VT:0010571)percentage of study population developing ventral prostate tumorous lesions during a period of time (CMO:0000943)20460660717617956Rat
70154Insul2Insulin level QTL 23.75blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)20669170617489458Rat
1581577Pur15Proteinuria QTL 154.380.0002urine total protein amount (VT:0000032)urine protein excretion rate (CMO:0000759)20804241017617956Rat
4889870Pur30Proteinuria QTL 30190.005urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)20804241029322208Rat
631265Iresp1Immunoglobin response QTL18.3blood anti-double stranded DNA antibody amount (VT:0004762)serum anti-DNA antibody level (CMO:0001533)20903971913461775Rat
7411652Foco24Food consumption QTL 240.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)201175751554435887Rat
9590092Insglur9Insulin/glucose ratio QTL 918.380.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)201175751554435887Rat

Markers in Region
RH94636  
Rat AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map20p12UniSTS


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_031051 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017601782 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC091362 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC061545 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473988 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ210474 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ213295 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ217414 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ218686 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ222835 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ223656 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ229019 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ229084 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JACYVU010000324 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  S73424 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U20999 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U62326 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSRNOT00000008608   ⟹   ENSRNOP00000008608
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2012,790,902 - 12,791,784 (+)Ensembl
Rnor_6.0 Ensembl2013,732,198 - 13,732,859 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000077564   ⟹   ENSRNOP00000074316
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2012,790,902 - 12,799,504 (+)Ensembl
RefSeq Acc Id: NM_031051   ⟹   NP_112313
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.22012,790,919 - 12,791,784 (+)NCBI
Rnor_6.02013,732,114 - 13,732,979 (+)NCBI
Rnor_5.02015,885,248 - 15,886,113 (+)NCBI
RGSC_v3.42013,191,986 - 13,192,851 (+)RGD
Celera2014,283,080 - 14,283,945 (+)RGD
Sequence:
Reference Sequences
RefSeq Acc Id: NP_112313   ⟸   NM_031051
- UniProtKB: P30904 (UniProtKB/Swiss-Prot),   A0A0F7RQL3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000008608   ⟸   ENSRNOT00000008608
RefSeq Acc Id: ENSRNOP00000074316   ⟸   ENSRNOT00000077564

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P30904-F1-model_v2 AlphaFold P30904 1-115 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13701531
Promoter ID:EPDNEW_R12055
Type:initiation region
Name:LOC103694877_1
Description:macrophage migration inhibitory factor
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.02013,732,146 - 13,732,206EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:621163 AgrOrtholog
BioCyc Gene G2FUF-4163 BioCyc
Ensembl Genes ENSRNOG00000006589 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000008608 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOP00000074316.2 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000008608 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOT00000077564.2 UniProtKB/TrEMBL
Gene3D-CATH 3.30.429.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:6920605 IMAGE-MGC_LOAD
InterPro Macrophage_inhib_fac UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Macrophage_inhib_fac_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Tautomerase/MIF_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:81683 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE MGC:72801 IMAGE-MGC_LOAD
NCBI Gene 81683 ENTREZGENE
PANTHER PTHR11954 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam MIF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Mif PhenoGen
PROSITE MIF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF55331 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0F7RQL3 ENTREZGENE, UniProtKB/TrEMBL
  A0A8L2R8Y3_RAT UniProtKB/TrEMBL
  MIF_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-03-09 Mif  macrophage migration inhibitory factor  LOC103694877  macrophage migration inhibitory factor  Data Merged 737654 PROVISIONAL
2017-08-16 Mif  macrophage migration inhibitory factor  Mif  macrophage migration inhibitory factor (glycosylation-inhibiting factor)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2014-08-25 LOC103694877  macrophage migration inhibitory factor      Symbol and Name status set to provisional 70820 PROVISIONAL
2013-02-27 Mif  macrophage migration inhibitory factor (glycosylation-inhibiting factor)  Mif  macrophage migration inhibitory factor  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-01-20 Mif  macrophage migration inhibitory factor      Symbol and Name status set to approved 1299863 APPROVED
2002-08-07 Mif  macrophage migration inhibitory factor      Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_disease serum levels increase dramatically in in acute pancreatitis 727512
gene_regulation protein expression is increased by dexamethasone treatment of the adrenal gland after ablation of the hypothalamic-pituitary-adrenal axis 729251