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Gene: Mif (macrophage migration inhibitory factor) Rattus norvegicus
Symbol: Mif
Name: macrophage migration inhibitory factor
Description: Predicted to have several functions, including identical protein binding activity; intramolecular oxidoreductase activity; and receptor ligand activity. Involved in several processes, including nervous system development; positive regulation of transport; and response to steroid hormone. Localizes to cytoplasm; extracellular space; and nucleus. Used to study several diseases, including cardiomyopathy (multiple); colitis; lung disease (multiple); retinitis; and toxic shock syndrome. Biomarker of borna disease; cystitis; kidney disease; myocardial infarction; and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in allergic hypersensitivity disease; asthma; cystic fibrosis; lung disease (multiple); and obesity. Orthologous to human MIF (macrophage migration inhibitory factor); PARTICIPATES IN alkaptonuria pathway; disulfiram pharmacodynamics pathway; dopamine beta-hydroxylase deficiency pathway; INTERACTS WITH 1,2,4-trimethylbenzene; 17alpha-ethynylestradiol; 17beta-estradiol.
Type: protein-coding
Also known as: glutathione-binding 13 kDa protein; L-dopachrome isomerase; L-dopachrome tautomerase; macrophage migration inhibitory factor (glycosylation-inhibiting factor); MGC72801; phenylpyruvate tautomerase
Homo sapiens (human) : MIF (macrophage migration inhibitory factor)  HGNC  Alliance
Mus musculus (house mouse) : Mif (macrophage migration inhibitory factor (glycosylation-inhibiting factor))  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Mif (macrophage migration inhibitory factor)
Pan paniscus (bonobo/pygmy chimpanzee) : MIF (macrophage migration inhibitory factor)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Mif (macrophage migration inhibitory factor)
Sus scrofa (pig) : MIF (macrophage migration inhibitory factor)
Chlorocebus sabaeus (African green monkey) : MIF (macrophage migration inhibitory factor)
Heterocephalus glaber (naked mole-rat) : Mif (macrophage migration inhibitory factor)
more info ...
Related Pseudogenes: Acyp2-ps1  
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.02013,715,219 - 13,732,980 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2013,732,198 - 13,732,859 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02015,885,248 - 15,886,113 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42013,191,986 - 13,192,851 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.12013,192,212 - 13,193,078 (+)NCBI
Celera2014,283,080 - 14,283,945 (+)NCBICelera
Cytogenetic Map20p12NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Mif
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 621163
Created: 2002-08-06
Species: Rattus norvegicus
Last Modified: 2020-03-04
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.