Lemd2 (LEM domain nuclear envelope protein 2)

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Gene: Lemd2 (LEM domain nuclear envelope protein 2) Rattus norvegicus

Analyze

Symbol:

Lemd2

Name:

LEM domain nuclear envelope protein 2

RGD ID:

1305341

Description:

Predicted to enable chromatin DNA binding activity. Predicted to be involved in several processes, including heart formation; negative regulation of signal transduction; and protein localization to chromatin. Predicted to act upstream of or within negative regulation of MAPK cascade and skeletal muscle cell differentiation. Predicted to be located in nuclear membrane. Predicted to be integral component of nuclear inner membrane. Predicted to colocalize with chromatin; endoplasmic reticulum; and nuclear envelope. Human ortholog(s) of this gene implicated in cataract 46 juvenile-onset. Orthologous to human LEMD2 (LEM domain nuclear envelope protein 2); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 3H-1,2-dithiole-3-thione; benzo[a]pyrene.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

LEM domain containing 2; LEM domain-containing protein 2; LEM domain-containing protein 2-like; LOC108348120; LOC361807; MGC112806

RGD Orthologs

Human

Mouse

Chinchilla

Bonobo

Dog

Squirrel

Pig

Green Monkey

Naked Mole-Rat

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	LEMD2 (LEM domain nuclear envelope protein 2)	HGNC	Ensembl, HomoloGene, Inparanoid, OrthoDB, OrthoMCL, Panther, Treefam
Mus musculus (house mouse):	Lemd2 (LEM domain containing 2)	HGNC	Treefam, OrthoMCL, HomoloGene, Inparanoid, Panther, OrthoDB, Ensembl
Chinchilla lanigera (long-tailed chinchilla):	Lemd2 (LEM domain nuclear envelope protein 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	LEMD2 (LEM domain nuclear envelope protein 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	LEMD2 (LEM domain nuclear envelope protein 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Lemd2 (LEM domain nuclear envelope protein 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	LEMD2 (LEM domain nuclear envelope protein 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	LEMD2 (LEM domain nuclear envelope protein 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Lemd2 (LEM domain nuclear envelope protein 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Homo sapiens (human):	LEMD2 (LEM domain nuclear envelope protein 2)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Lemd2 (LEM domain containing 2)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	lem-2	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB)
Drosophila melanogaster (fruit fly):	MAN1	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|OrthoFinder\|PANTHER)
Saccharomyces cerevisiae (baker's yeast):	SRC1	Alliance	DIOPT (Ensembl Compara\|PhylomeDB)

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	20	5,282,397 - 5,296,621 (-)	NCBI	mRatBN7.2
mRatBN7.2 Ensembl	20	5,282,397 - 5,296,626 (-)	Ensembl
Rnor_6.0	20	5,779,742 - 5,786,213 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	20	6,545,083 - 6,556,350 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	20	8,789,656 - 8,800,115 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	20	5,425,689 - 5,436,856 (-)	NCBI	RGSC3.4		rn4	RGSC3.4
RGSC_v3.1	20	5,426,758 - 5,496,911 (-)	NCBI
Celera	20	6,846,384 - 6,857,575 (-)	NCBI		Celera
Cytogenetic Map	20	p12	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

autosomal dominant intellectual developmental disorder 5 (ISO)

cataract (ISO)

cataract 46 juvenile-onset (ISO)

Dwarfism (ISO)

exophthalmos (ISO)

microcephaly (ISO)

Micrognathism (ISO)

Supernumerary Tooth (ISO)

Tremor (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1,2-dimethylhydrazine (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

3-isobutyl-1-methyl-7H-xanthine (ISO)

3H-1,2-dithiole-3-thione (EXP)

4,4'-sulfonyldiphenol (ISO)

aflatoxin B1 (ISO)

benzo[a]pyrene (EXP,ISO)

bisphenol A (EXP,ISO)

bisphenol F (ISO)

C60 fullerene (EXP)

clofibrate (ISO)

clozapine (ISO)

copper atom (ISO)

copper(0) (ISO)

Cuprizon (ISO)

cyclosporin A (ISO)

dexamethasone (ISO)

disulfiram (ISO)

doxorubicin (ISO)

fenthion (ISO)

flutamide (EXP)

folic acid (ISO)

indometacin (ISO)

ivermectin (ISO)

methidathion (ISO)

mitoxantrone (ISO)

N-methyl-4-phenylpyridinium (EXP)

paracetamol (EXP,ISO)

potassium dichromate (ISO)

sunitinib (ISO)

trichloroethene (EXP)

urethane (ISO)

valproic acid (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

heart formation (ISO)

negative regulation of MAPK cascade (ISO)

negative regulation of protein kinase B signaling (ISO)

neurogenesis (ISO)

nuclear envelope organization (ISO)

protein localization to chromatin (ISO)

skeletal muscle cell differentiation (ISO)

Cellular Component

chromatin (ISO)

endoplasmic reticulum (ISO)

integral component of nuclear inner membrane (ISO)

nuclear envelope (ISO)

nuclear membrane (ISO)

Molecular Function

protein binding (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:12477932	PMID:16339967	PMID:17097643	PMID:19720741	PMID:19946888	PMID:25790465	PMID:28242692

Genomics

Comparative Map Data

Lemd2
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	20	5,282,397 - 5,296,621 (-)	NCBI	mRatBN7.2
mRatBN7.2 Ensembl	20	5,282,397 - 5,296,626 (-)	Ensembl
Rnor_6.0	20	5,779,742 - 5,786,213 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	20	6,545,083 - 6,556,350 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	20	8,789,656 - 8,800,115 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	20	5,425,689 - 5,436,856 (-)	NCBI	RGSC3.4		rn4	RGSC3.4
RGSC_v3.1	20	5,426,758 - 5,496,911 (-)	NCBI
Celera	20	6,846,384 - 6,857,575 (-)	NCBI		Celera
Cytogenetic Map	20	p12	NCBI

LEMD2
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	6	33,771,213 - 33,789,130 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p13 Ensembl	6	33,771,202 - 33,789,130 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	6	33,738,990 - 33,756,907 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	6	33,846,968 - 33,864,874 (-)	NCBI	NCBI36		hg18	NCBI36
Celera	6	35,293,376 - 35,311,312 (-)	NCBI
Cytogenetic Map	6	p21.31	NCBI
HuRef	6	33,480,936 - 33,498,853 (-)	NCBI		HuRef
CHM1_1	6	33,741,239 - 33,759,156 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	6	33,592,393 - 33,610,310 (-)	NCBI

Lemd2
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	17	27,408,574 - 27,426,228 (-)	NCBI	GRCm39		mm39
GRCm39 Ensembl	17	27,408,574 - 27,423,443 (-)	Ensembl
GRCm38	17	27,189,600 - 27,205,470 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	17	27,189,600 - 27,204,469 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	17	27,326,545 - 27,341,383 (-)	NCBI	GRCm37		mm9	NCBIm37
MGSCv36	17	26,917,346 - 26,931,337 (-)	NCBI			mm8
Celera	17	27,725,463 - 27,740,360 (-)	NCBI		Celera
Cytogenetic Map	17	A3.3	NCBI

Lemd2
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955437	2,163,878 - 2,176,665 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955437	2,163,977 - 2,178,783 (-)	NCBI	ChiLan1.0	ChiLan1.0

LEMD2
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
PanPan1.1	6	34,452,332 - 34,469,795 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
Mhudiblu_PPA_v0	6	33,344,372 - 33,363,143 (-)	NCBI	Mhudiblu_PPA_v0		panPan3

LEMD2
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	12	3,114,175 - 3,131,779 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	12	3,115,460 - 3,131,919 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	12	3,130,070 - 3,147,660 (-)	NCBI
ROS_Cfam_1.0	12	3,446,589 - 3,464,216 (-)	NCBI
ROS_Cfam_1.0 Ensembl	12	3,447,058 - 3,464,190 (-)	Ensembl
UMICH_Zoey_3.1	12	3,112,813 - 3,130,403 (-)	NCBI
UNSW_CanFamBas_1.0	12	3,194,850 - 3,212,427 (-)	NCBI
UU_Cfam_GSD_1.0	12	3,292,189 - 3,309,758 (-)	NCBI

Lemd2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404946	38,771,969 - 38,789,333 (-)	NCBI
SpeTri2.0	NW_004936476	25,170,954 - 25,188,298 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

LEMD2
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	7	29,980,395 - 29,997,356 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	7	29,980,394 - 29,997,077 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	7	34,640,183 - 34,656,850 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

LEMD2
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	17	38,291,100 - 38,309,134 (+)	NCBI	ChlSab1.1		chlSab2
ChlSab1.1 Ensembl	17	38,291,217 - 38,307,745 (+)	Ensembl	ChlSab1.1		chlSab2
Vero_WHO_p1.0	NW_023666044	33,664,152 - 33,682,118 (-)	NCBI	Vero_WHO_p1.0

Lemd2
(Heterocephalus glaber - naked mole-rat)

Naked Mole-rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624754	23,158,985 - 23,173,885 (+)	Ensembl	HetGla_female_1.0		hetGla2
HetGla 1.0	NW_004624754	23,159,234 - 23,173,452 (+)	NCBI	HetGla_female_1.0		hetGla2

Position Markers

RH139300

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	20	5,282,578 - 5,282,738 (+)	MAPPER	mRatBN7.2
Rnor_6.0	20	6,545,107 - 6,545,266	NCBI	Rnor6.0
Rnor_6.0	20	5,779,766 - 5,779,925	NCBI	Rnor6.0
Rnor_5.0	20	8,789,680 - 8,789,839	UniSTS	Rnor5.0
RGSC_v3.4	20	5,425,713 - 5,425,872	UniSTS	RGSC3.4
Celera	20	6,846,408 - 6,846,567	UniSTS
RH 3.4 Map	20	57.14	UniSTS
Cytogenetic Map	20	p12	UniSTS

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1354642	Despr15	Despair related QTL 15		0.0027	locomotor behavior trait (VT:0001392)	amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)	20	1	24159021	Rat
1600382	Edcs3	Endometrial carcinoma susceptibility QTL3	3.5	0.003	uterus morphology trait (VT:0001120)	percentage of study population developing endometrioid carcinoma during a period of time (CMO:0001759)	20	1	25159026	Rat
2317851	Alcrsp22	Alcohol response QTL 22	3.2	0.05	response to alcohol trait (VT:0010489)	duration of loss of righting reflex (CMO:0002289)	20	1	27339237	Rat
1641893	Alcrsp7	Alcohol response QTL 7			response to alcohol trait (VT:0010489)	duration of loss of righting reflex (CMO:0002289)	20	1	27339237	Rat
8694189	Bw153	Body weight QTL 153	3.13	0.001	body mass (VT:0001259)	body weight gain (CMO:0000420)	20	1	29191651	Rat
9590275	Scort15	Serum corticosterone level QTL 15	3.48	0.001	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	20	1	29191651	Rat
7411650	Foco23	Food consumption QTL 23	20.7	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	20	1	29191651	Rat
9590109	Sffal8	Serum free fatty acids level QTL 8	5.32	0.01	blood free fatty acid amount (VT:0001553)	plasma free fatty acids level (CMO:0000546)	20	1	29191651	Rat
9589155	Insul32	Insulin level QTL 32	6.38	0.001	blood insulin amount (VT:0001560)	plasma insulin level (CMO:0000342)	20	1	29191651	Rat
6893685	Bw111	Body weight QTL 111	2.7	0.004	body mass (VT:0001259)	body weight (CMO:0000012)	20	1	32578807	Rat
7411668	Foco32	Food consumption QTL 32	8	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	20	1	36600972	Rat
9590252	Scort12	Serum corticosterone level QTL 12	20.46	0.001	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	20	1	36600972	Rat
2305926	Iddm37	Insulin dependent diabetes mellitus QTL 37	6		blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	20	1527842	46527842	Rat
2306850	Pia40	Pristane induced arthritis QTL 40		0.0001	joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	20	1527959	5304575	Rat
1641915	Colcr9	Colorectal carcinoma resistance QTL 9	2.97	0.0024	intestine integrity trait (VT:0010554)	benign colorectal tumor number (CMO:0001795)	20	1530655	46530655	Rat
1598816	Memor12	Memory QTL 12	2.4		exploratory behavior trait (VT:0010471)	average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)	20	2606836	47606836	Rat
2317057	Aia27	Adjuvant induced arthritis QTL 27	2.83		joint integrity trait (VT:0010548)	right rear ankle joint diameter (CMO:0002150)	20	2892597	26381954	Rat
1300152	Bp195	Blood pressure QTL 195	3.46		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	20	3621649	9243559	Rat
1331772	Cdexp2	CD45RC expression in CD8 T cells QTL 2	5.7		CD8-positive T cell quantity (VT:0008077)	blood CD45RC(high) CD8 T cell count to CD45RC(low) CD8 T cell count ratio (CMO:0001990)	20	3621649	10078919	Rat
61432	Cia1	Collagen induced arthritis QTL 1			joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	20	3621656	14101050	Rat
61474	Eae1	Experimental allergic encephalomyelitis QTL 1	3		nervous system integrity trait (VT:0010566)	experimental autoimmune encephalomyelitis severity score (CMO:0001419)	20	4606607	6691706	Rat
4889857	Pur27	Proteinuria QTL 27	12.2	0.001	total urine protein amount (VT:0000032)	urine total protein excretion rate (CMO:0000756)	20	4606607	17617956	Rat
1558640	Prcs2	Prostate cancer susceptibility QTL 2	3.3		prostate integrity trait (VT:0010571)	percentage of study population developing ventral prostate tumorous lesions during a period of time (CMO:0000943)	20	4606607	17617956	Rat

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	146
Count of miRNA genes:	114
Interacting mature miRNAs:	133
Transcripts:	ENSRNOT00000035819
Prediction methods:	Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium	1				2				14			1
Low	2	43	57	41	17	41	8	11	60	35	41	10	8
Below cutoff

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001039032	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039098814	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039098815	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC141521	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC098775	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JACYVU010000324	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Reference Sequences

RefSeq Acc Id:

ENSRNOT00000035819 ⟹ ENSRNOP00000036495

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	20	5,282,556 - 5,295,660 (-)	Ensembl
Rnor_6.0 Ensembl	20	6,545,083 - 6,556,350 (-)	Ensembl

RefSeq Acc Id:

ENSRNOT00000091051

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	20	5,282,556 - 5,292,095 (-)	Ensembl

RefSeq Acc Id:

ENSRNOT00000093645

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	20	5,286,925 - 5,291,470 (-)	Ensembl
Rnor_6.0 Ensembl	20	6,549,269 - 6,553,925 (-)	Ensembl

RefSeq Acc Id:

ENSRNOT00000093711 ⟹ ENSRNOP00000076316

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0 Ensembl	20	6,547,620 - 6,548,179 (-)	Ensembl

RefSeq Acc Id:

ENSRNOT00000099806

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	20	5,282,556 - 5,296,626 (-)	Ensembl

RefSeq Acc Id:

ENSRNOT00000111549

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	20	5,282,397 - 5,290,685 (-)	Ensembl

RefSeq Acc Id:

NM_001039032 ⟹ NP_001034121

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	20	5,282,555 - 5,293,746 (-)	NCBI
Rnor_6.0	20	5,779,742 - 5,786,213 (-)	NCBI
Rnor_5.0	20	8,789,656 - 8,800,115 (-)	NCBI
RGSC_v3.4	20	5,425,689 - 5,436,856 (-)	RGD
Celera	20	6,846,384 - 6,857,575 (-)	RGD

Sequence:

show sequence

CAGCTGTACATAGGAAGACCCATGCAATTCCATTTTCAGGACCAGAAACAGAGGTTAAGTTACC
CAGGAATCGGTGGCTGCTGGAAAGGCCCTAATTACCAGTGTCCTGACCCAGCATGAGGAACCCT
TGGGTCTTGGAGCCTGCACTGTACTGGCCACTGACAGATGGATCTTCCGGTCTCTACCTTTGTG
CCAGCCAAGTTTTGCTTCCCCTGGGTCTTGAGAGGTCTCTCTGTTACCCAGTCCCACTTTTAAC
CTTTCTCTTTCTTTTCTTGGTCTCAGTGAAATTGTTGCCGGTGGACTGTGAGAGAAAAACAGAT
GAGTTCTGCCAGGCCAGGCAGAAGGCGGCCCTGCTGGAGCTGTTGCATGAGCTGTACAACTTCC
TGGCCATCCAAGCAGGTAATTTTGAGTGTGGCAATCCGGAGAAGCTAAAGAGCAAATGCATCCC
TGTCCTGGAGGCCCAGGAGTACATAGCTAACGTGACCAGCAGTTCCTCTTCGAGGTTTAAGGCT
GCACTGACCTGGATACTGAGCAGCAACAAGGATGTGGGCATCTGGCTGAAAGGGGAAGACCCAT
CTGAGCTAGTGACCACCGTGGACAAAGTGGTCTGCCTGGAGTCCGCCCGGCCCCGGATGGGCAT
GGGCTGCCGCCTCAGCCGCGCCCTGCTCACCGCGGTTACCCATGTGCTCATCTTTTTCTGGTGC
CTGGCCTTCCTGTGGGGGCTGCTGATCCTCCTGAAGTACCGATGGCGGAAGCTTGAAGAGGAAG
AGCAGGCCATGTATGAGATGGTGAAGAAGATCATAGATGTGGTTCAGGACCACTATGTGGACTG
GGAACAGGACATGGAGCGCTACCCCTACGTGGGCATCCTTCACGTGCGCGACAGTCTAATCCCC
CCACAGAGCAGGCGGCGCATGAAGCGAGTATGGGACCGCGCCGTGGAATTCCTGGCTTCCAATG
AATCTCGGATCCAGACCGAGTCCCACCGAGTGGCCGGGGAGGACATGCTGGTGTGGAGATGGAC
TAAGCCTTCCTCCTTCTCTGACTCGGAGCGATAGGACAGGGCCTAATCAGCCAGCCTGGCTTGG
CTGTGCCACCCAGCTGGGGCAAGGACACAGACCCTCGGTGCTCATTCACACCTGCCTTGATTGC
CCTCCTGGTCTCCATTCTGGGACACATGGGCTTACTTAGGGGAGCCAGGAGAACGGGGAAGCCC
CTCCTCTATGCCAGTATTACTGACAGAAGGGAGAATGGCTTGTTCTCCCTGGATAAATCCTGGA
GGTTCTGCACTCAGCTAGACAGCAGACAGTGATCCTGAAGTCCCTCGCTTGGGAGGTGGGTCGG
GTGGTGGGCTGGGGTAGCAGGGGCCTGGGGAAAGCTTGGCCCATGTGCCTTTGTGCTGTTCCCA
GCGAGCTTAAGGGTGAGGGGAGGAATCCCGCCCCACTCCTGCATGGGCCTCTTTGTCCAGAGGA
GGAGATGTTAGAACTTACAGAACAGAGGCGGCTGGGATCCGGAAGGGGCGGAAGCTCCAGCCAC
AGCTGCCTGTGCCTCAGTGCATCTCACAGGTCAGCAGTGCAGCCTGAGCCGGGGTGGAGCACAG
CCTCATCACGACTGTGACCGGGCCTCTCCTGACCGGCTGGCCAGAACAGATAGGGTGCAGCATC
ATGGCTGCACACTGCCCTCTGCAGGCCTCATGGAGCAACGTGGGCCATTAGCACTCTGCTAGGG
AAGACCTGCTCCAAAAACACCCAGTGGGAGGCCTCATTGGCTGAGGGAGGCTTTCCAGCAACTG
GTCCAGCGGGCCTCACCCACAGCAGCTGGAGTAGCCCCTGGAGGTGACGCAGCTGCCCCTTTTG
GACCTATTGCTGTTCTGTTTCTTAATAAAGTACCATCTCCGTCTAAAAAAAAAAAAAAAAAAAA
AAAAA

hide sequence

RefSeq Acc Id:

XM_039098814 ⟹ XP_038954742

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	20	5,282,397 - 5,296,621 (-)	NCBI

RefSeq Acc Id:

XM_039098815 ⟹ XP_038954743

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	20	5,282,397 - 5,296,621 (-)	NCBI

Protein Sequences


Protein RefSeqs	NP_001034121	(Get FASTA)	NCBI Sequence Viewer
	XP_038954742	(Get FASTA)	NCBI Sequence Viewer
	XP_038954743	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAH98775	(Get FASTA)	NCBI Sequence Viewer

Reference Sequences

RefSeq Acc Id:

NP_001034121 ⟸ NM_001039032

- Sequence:

show sequence

MRNPWVLEPALYWPLTDGSSGLYLCASQVLLPLGLERSLCYPVPLLTFLFLFLVSVKLLPVDCE
RKTDEFCQARQKAALLELLHELYNFLAIQAGNFECGNPEKLKSKCIPVLEAQEYIANVTSSSSS
RFKAALTWILSSNKDVGIWLKGEDPSELVTTVDKVVCLESARPRMGMGCRLSRALLTAVTHVLI
FFWCLAFLWGLLILLKYRWRKLEEEEQAMYEMVKKIIDVVQDHYVDWEQDMERYPYVGILHVRD
SLIPPQSRRRMKRVWDRAVEFLASNESRIQTESHRVAGEDMLVWRWTKPSSFSDSER

hide sequence

RefSeq Acc Id:

ENSRNOP00000036495 ⟸ ENSRNOT00000035819

RefSeq Acc Id:

ENSRNOP00000076316 ⟸ ENSRNOT00000093711

RefSeq Acc Id:	XP_038954743 ⟸ XM_039098815
- Peptide Label:	isoform X2

RefSeq Acc Id:	XP_038954742 ⟸ XM_039098814
- Peptide Label:	isoform X1

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q4KM57-F1-model_v2	AlphaFold	Q4KM57	1-313	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Strain Variation

Strain Sequence Variants (MRatBN7.2)

ACI/EurMcwi (2019)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	MCW
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

ACI/N (2020)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	NIH
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

BN-Lx/CubMcwi (2019)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	MCW
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

BN/NHsdMcwi (2019)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	MCW
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

BN/NHsdMcwi (2020)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	MCW
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

BN/SsN (2020)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	NIH
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

BUF/N (2020)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	NIH
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

BXH2/CubMcwi (2020)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	MCW
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

BXH3/CubMcwi (2020)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	MCW
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

DA/OlaHsd (2019)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	Envigo
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

F344/DuCrl (2019)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	Charles River
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

F344/N (2020)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	NIH
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

F344/NCrl (2019)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	Charles River
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

F344/Stm (2019)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	Japan
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

FHH/EurMcwi (2019)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	MCW
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

FXLE16/Stm (2020)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	Japan
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

FXLE18/Stm (2020)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	Japan
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

GK/FarMcwi (2019)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	MCW
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

HXB10/IpcvMcwi (2019)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	MCW
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

HXB2/IpcvMcwi (2019)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	MCW
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

HXB20/IpcvMcwi (2020)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	MCW
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

HXB31/IpcvMcwi (2019)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	MCW
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

HXB4/IpcvMcwi (2020)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	MCW
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

LE/Stm (2019)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	MCW
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

LEW/Crl (2019)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	Charles River
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

LEXF10A/StmMcwi (2020)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	MCW
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

LEXF11/Stm (2020)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	Japan
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

LEXF1A/Stm (2019)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	Japan
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

LEXF1C/Stm (2019)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	Japan
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

LEXF2B/Stm (2019)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	Japan
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

LEXF3/Stm (2020)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	Japan
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

LEXF4/Stm (2020)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	Japan
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

LH/MavRrrcAek (2020)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	Kwitek
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

LL/MavRrrcAek (2020)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	Kwitek
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

LN/MavRrrcAek (2020)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	Kwitek
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

M520/N (2020)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	NIH
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

M520/NRrrcMcwi (2019)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	MCW
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

MR/N (2020)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	NIH
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

MWF/Hsd (2019)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	MCW
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

PVG/Seac (2019)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	Japan
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

SHR/OlalpcvMcwi (2019)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	MCW
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

SHRSP/A3NCrl (2019)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	Charles River
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

SR/JrHsd (2020)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	Envigo
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

SS/JrHsdMcwi (2019)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	MCW
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

WAG/RijCrl (2020)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	Charles River
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

WKY/N (2020)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	NIH
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

WKY/NCrl (2019)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	Charles River
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

WN/N (2020)

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Platform:	GSPMC-Illumina-NovaSeq6000
Secondary Analysis:	BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder:	NIH
Description:	Dr. Mindy Dwinell - Hybrid rat diversity program

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1305341	AgrOrtholog
BioCyc Gene	G2FUF-4488	BioCyc
Ensembl Genes	ENSRNOG00000025864	Ensembl, ENTREZGENE
Ensembl Transcript	ENSRNOT00000091051	ENTREZGENE
	ENSRNOT00000099806	ENTREZGENE
Gene3D-CATH	1.10.10.1180	UniProtKB/TrEMBL
IMAGE_CLONE	IMAGE:7373953	IMAGE-MGC_LOAD
InterPro	Inner-Nucl-membr_MAN1	UniProtKB/TrEMBL
	LEMD2	UniProtKB/TrEMBL
	MAN1_winged_helix_dom	UniProtKB/TrEMBL
KEGG Report	rno:361807	UniProtKB/TrEMBL
MGC_CLONE	MGC:112806	IMAGE-MGC_LOAD
NCBI Gene	361807	ENTREZGENE
PANTHER	PTHR13428:SF8	UniProtKB/TrEMBL
Pfam	MAN1_C	UniProtKB/TrEMBL
PhenoGen	Lemd2	PhenoGen
UniProt	Q4KM57_RAT	UniProtKB/TrEMBL
UniProt Secondary	D3ZED5	UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2021-03-09	Lemd2	LEM domain nuclear envelope protein 2	LOC108348120	LEM domain-containing protein 2-like	Data Merged	737654	PROVISIONAL
2019-11-11	Lemd2	LEM domain nuclear envelope protein 2	Lemd2	LEM domain containing 2	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2016-08-02	LOC108348120	LEM domain-containing protein 2-like			Symbol and Name status set to provisional	70820	PROVISIONAL
2005-12-06	Lemd2	LEM domain containing 2	Lemd2_predicted	LEM domain containing 2 (predicted)	Symbol and Name updated	1559027	APPROVED
2005-01-12	Lemd2_predicted	LEM domain containing 2 (predicted)			Symbol and Name status set to approved	70820	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - ClinVar

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