Edar (ectodysplasin-A receptor) - Rat Genome Database

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Gene: Edar (ectodysplasin-A receptor) Rattus norvegicus
Analyze
Symbol: Edar
Name: ectodysplasin-A receptor
RGD ID: 1561714
Description: Predicted to enable transmembrane signaling receptor activity. Predicted to be involved in positive regulation of I-kappaB kinase/NF-kappaB signaling and positive regulation of JNK cascade. Predicted to act upstream of or within several processes, including hair follicle development; positive regulation of NIK/NF-kappaB signaling; and salivary gland cavitation. Predicted to be located in apical part of cell. Predicted to be active in plasma membrane. Human ortholog(s) of this gene implicated in ectodermal dysplasia 10A and ectodermal dysplasia 10B. Orthologous to human EDAR (ectodysplasin A receptor); PARTICIPATES IN cytokine mediated signaling pathway; INTERACTS WITH (+)-schisandrin B; 1-naphthyl isothiocyanate; acetamide.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC365581; RGD1561714; similar to Ectodysplasin-A receptor; similar to Tumor necrosis factor receptor superfamily member EDAR precursor (Anhidrotic ectodysplasin receptor 1) (Ectodysplasin-A receptor) (Ectodermal dysplasia receptor) (Downless); tumor necrosis factor receptor superfamily member EDAR
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.22026,587,836 - 26,666,543 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2026,587,839 - 26,666,494 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2027,595,453 - 27,623,881 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.02026,981,678 - 27,010,102 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.02027,726,632 - 27,755,014 (-)NCBIRnor_WKY
Rnor_6.02028,179,132 - 28,263,092 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2028,179,140 - 28,263,037 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02029,996,972 - 30,079,875 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42037,135,534 - 37,164,197 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera2028,038,358 - 28,066,702 (-)NCBICelera
Cytogenetic Map20q11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Role of ectodysplasin signalling in middle ear and nasal pathology in rat and mouse models of hypohidrotic ectodermal dysplasia. Del-Pozo J, etal., Dis Model Mech. 2019 Apr 25;12(4). pii: 12/4/dmm037804. doi: 10.1242/dmm.037804.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Mutations in the human homologue of mouse dl cause autosomal recessive and dominant hypohidrotic ectodermal dysplasia. Monreal AW, etal., Nat Genet. 1999 Aug;22(4):366-9.
4. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
5. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
6. GOA pipeline RGD automated data pipeline
7. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
8. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
9. Comprehensive gene review and curation RGD comprehensive gene curation
Additional References at PubMed
PMID:544312   PMID:11039935   PMID:12629675   PMID:18508042  


Genomics

Comparative Map Data
Edar
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.22026,587,836 - 26,666,543 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2026,587,839 - 26,666,494 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2027,595,453 - 27,623,881 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.02026,981,678 - 27,010,102 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.02027,726,632 - 27,755,014 (-)NCBIRnor_WKY
Rnor_6.02028,179,132 - 28,263,092 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2028,179,140 - 28,263,037 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02029,996,972 - 30,079,875 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42037,135,534 - 37,164,197 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera2028,038,358 - 28,066,702 (-)NCBICelera
Cytogenetic Map20q11NCBI
EDAR
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382108,894,471 - 108,989,220 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl2108,894,471 - 108,989,372 (-)EnsemblGRCh38hg38GRCh38
GRCh372109,510,927 - 109,605,676 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362108,877,361 - 108,972,260 (-)NCBINCBI36Build 36hg18NCBI36
Build 342108,969,448 - 109,064,346NCBI
Celera2103,820,860 - 103,915,790 (-)NCBICelera
Cytogenetic Map2q13NCBI
HuRef2103,109,351 - 103,204,259 (-)NCBIHuRef
CHM1_12109,515,194 - 109,610,098 (-)NCBICHM1_1
T2T-CHM13v2.02109,355,029 - 109,449,802 (-)NCBIT2T-CHM13v2.0
Edar
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391058,436,602 - 58,511,518 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1058,436,611 - 58,511,476 (-)EnsemblGRCm39 Ensembl
GRCm381058,600,780 - 58,675,696 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1058,600,789 - 58,675,654 (-)EnsemblGRCm38mm10GRCm38
MGSCv371058,063,536 - 58,138,444 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361058,582,058 - 58,656,978 (-)NCBIMGSCv36mm8
MGSCv361057,996,146 - 58,071,053 (-)NCBIMGSCv36mm8
Cytogenetic Map10B4NCBI
cM Map1029.37NCBI
Edar
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495547012,309,048 - 12,362,570 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495547012,310,680 - 12,362,555 (-)NCBIChiLan1.0ChiLan1.0
EDAR
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.12A110,146,499 - 110,241,556 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2A110,146,499 - 110,234,398 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v02A95,132,396 - 95,172,218 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
EDAR
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11034,873,311 - 34,943,140 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1034,848,526 - 34,940,784 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1034,772,071 - 34,866,543 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01035,700,824 - 35,795,378 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1035,700,812 - 35,795,448 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11035,430,446 - 35,524,880 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01035,712,643 - 35,807,092 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01035,901,219 - 35,995,761 (+)NCBIUU_Cfam_GSD_1.0
Edar
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440629291,938,934 - 91,970,049 (+)NCBIHiC_Itri_2
SpeTri2.0NW_004936829429,667 - 458,943 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
EDAR
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl347,396,330 - 47,465,784 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1347,396,303 - 47,466,234 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2349,558,908 - 49,626,194 (+)NCBISscrofa10.2Sscrofa10.2susScr3
EDAR
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11412,430,405 - 12,527,160 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1412,433,418 - 12,468,841 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660807,173,441 - 7,274,919 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Edar
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474911,983,550 - 11,998,918 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474911,981,782 - 11,998,933 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Position Markers
D20Rat36  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22026,621,485 - 26,621,635 (+)MAPPERmRatBN7.2
Rnor_6.02028,218,193 - 28,218,342NCBIRnor6.0
Rnor_5.02030,035,898 - 30,036,047UniSTSRnor5.0
RGSC_v3.42037,132,181 - 37,132,331RGDRGSC3.4
RGSC_v3.42037,132,182 - 37,132,331UniSTSRGSC3.4
RGSC_v3.12037,145,981 - 37,146,131RGD
Celera2028,069,905 - 28,070,055UniSTS
SHRSP x BN Map2021.46UniSTS
SHRSP x BN Map2021.46RGD
FHH x ACI Map2012.4099RGD
Cytogenetic Map20q11UniSTS


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2317851Alcrsp22Alcohol response QTL 223.20.05response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)20127339237Rat
1641893Alcrsp7Alcohol response QTL 7response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)20127339237Rat
8694189Bw153Body weight QTL 1533.130.001body mass (VT:0001259)body weight gain (CMO:0000420)20129191651Rat
9590275Scort15Serum corticosterone level QTL 153.480.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)20129191651Rat
7411650Foco23Food consumption QTL 2320.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)20129191651Rat
9590109Sffal8Serum free fatty acids level QTL 85.320.01blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)20129191651Rat
9589155Insul32Insulin level QTL 326.380.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)20129191651Rat
6893685Bw111Body weight QTL 1112.70.004body mass (VT:0001259)body weight (CMO:0000012)20132578807Rat
7411668Foco32Food consumption QTL 3280.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)20136600972Rat
9590252Scort12Serum corticosterone level QTL 1220.460.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)20136600972Rat
2305926Iddm37Insulin dependent diabetes mellitus QTL 376blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)20152784246527842Rat
1641915Colcr9Colorectal carcinoma resistance QTL 92.970.0024intestine integrity trait (VT:0010554)benign colorectal tumor number (CMO:0001795)20153065546530655Rat
1598816Memor12Memory QTL 122.4exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)20260683647606836Rat
4889870Pur30Proteinuria QTL 30190.005total urine protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)20804241029322208Rat
7411652Foco24Food consumption QTL 240.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)201175751554435887Rat
9590092Insglur9Insulin/glucose ratio QTL 918.380.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)201175751554435887Rat
4889610Pancm3Pancreatic morphology QTL 33.750.001pancreas mass (VT:0010144)pancreas wet weight (CMO:0000626)201761783247606836Rat
2317880Alcrsp25Alcohol response QTL 252.3response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)201769755054435887Rat
2303626Vencon10Ventilatory control QTL 100.001respiration trait (VT:0001943)respiration rate (CMO:0000289)201919072154435887Rat
2303578Gluco50Glucose level QTL 502blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)202510672254435887Rat
2303587Bw93Body weight QTL 9313body mass (VT:0001259)body weight (CMO:0000012)202510672254435887Rat
2300188Bmd68Bone mineral density QTL 686.40.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)202510672254435887Rat
1331747Hrtrt16Heart rate QTL 163.163heart pumping trait (VT:2000009)heart rate (CMO:0000002)202520973454435887Rat

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:801
Count of miRNA genes:313
Interacting mature miRNAs:400
Transcripts:ENSRNOT00000030348
Prediction methods:Microtar, Miranda
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 1 1 1
Low 3 30 20 19 20 7 10 60 24 21 2 7
Below cutoff 9 10 6 6 1 1 14 11 16 9 1

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000030348   ⟹   ENSRNOP00000029258
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2026,587,839 - 26,666,494 (-)Ensembl
Rnor_6.0 Ensembl2028,179,140 - 28,263,037 (-)Ensembl
RefSeq Acc Id: NM_001191899   ⟹   NP_001178828
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.22026,589,898 - 26,618,283 (-)NCBI
Rnor_6.02028,181,194 - 28,214,990 (-)NCBI
Rnor_5.02029,996,972 - 30,079,875 (-)NCBI
Celera2028,038,358 - 28,066,702 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006256381   ⟹   XP_006256443
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.22026,587,836 - 26,666,543 (-)NCBI
Rnor_6.02028,179,132 - 28,263,092 (-)NCBI
Rnor_5.02029,996,972 - 30,079,875 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039098901   ⟹   XP_038954829
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.22026,587,836 - 26,666,543 (-)NCBI
RefSeq Acc Id: XM_039098902   ⟹   XP_038954830
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.22026,587,836 - 26,666,543 (-)NCBI
RefSeq Acc Id: XM_039098903   ⟹   XP_038954831
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.22026,587,836 - 26,666,543 (-)NCBI
Reference Sequences
RefSeq Acc Id: NP_001178828   ⟸   NM_001191899
- Peptide Label: precursor
- UniProtKB: D3ZGP2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006256443   ⟸   XM_006256381
- Peptide Label: isoform X4
- UniProtKB: D3ZGP2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000029258   ⟸   ENSRNOT00000030348
RefSeq Acc Id: XP_038954831   ⟸   XM_039098903
- Peptide Label: isoform X3
RefSeq Acc Id: XP_038954830   ⟸   XM_039098902
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038954829   ⟸   XM_039098901
- Peptide Label: isoform X1

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZGP2-F1-model_v2 AlphaFold D3ZGP2 1-448 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13701583
Promoter ID:EPDNEW_R12107
Type:initiation region
Name:Edar_1
Description:ectodysplasin-A receptor
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.02028,263,067 - 28,263,127EPDNEW

Strain Variation

Strain Sequence Variants (mRatBN7.2)
ACI/EurMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
ACI/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN-Lx/CubMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/NHsdMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/NHsdMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BN/SsN (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BUF/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BXH2/CubMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
BXH3/CubMcwi (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
DA/OlaHsd (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Envigo
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/DuCrl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/N (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/NCrl (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
F344/Stm (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FHH/EurMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FXLE16/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
FXLE18/Stm (2020)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
GK/FarMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB10/IpcvMcwi (2019)
Visual CSV TAB Printer
Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB2/IpcvMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB20/IpcvMcwi (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB31/IpcvMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
HXB4/IpcvMcwi (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LE/Stm (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEW/Crl (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF10A/StmMcwi (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF11/Stm (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF1A/Stm (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF1C/Stm (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF2B/Stm (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF3/Stm (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LEXF4/Stm (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LH/MavRrrcAek (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LL/MavRrrcAek (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
LN/MavRrrcAek (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Kwitek
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
M520/N (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
M520/NRrrcMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
MR/N (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
MWF/Hsd (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
PVG/Seac (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Japan
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SHR/OlalpcvMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SHRSP/A3NCrl (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SR/JrHsd (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Envigo
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
SS/JrHsdMcwi (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: MCW
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WAG/RijCrl (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WKY/N (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WKY/NCrl (2019)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: Charles River
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
WN/N (2020)
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Platform: GSPMC-Illumina-NovaSeq6000
Secondary Analysis: BWA_mem_v.0.7.17,_GATK_v.4.1.3.0
Breeder: NIH
Description: Dr. Mindy Dwinell - Hybrid rat diversity program
Damaging Variants


Assembly: Rnor_6.0

Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Strain
20 28181405 28181406 T C snv F344/NRrrc (MCW), WN/N (MCW), Buf/N (MCW), ACI/N (MCW)
20 28186275 28186276 C A snv F344/NRrrc (MCW), ACI/N (MCW), Buf/N (MCW), MR/N (MCW), WN/N (MCW)
20 28186278 28186279 C T snv WN/N (MCW), MR/N (MCW), F344/NRrrc (MCW), ACI/N (MCW), Buf/N (MCW)
20 28213417 28213418 T C snv ACI/N (MCW)
20 28213444 28213445 C T snv ACI/N (MCW)
20 28213471 28213472 G A snv ACI/N (MCW)


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1561714 AgrOrtholog
BioCyc Gene G2FUF-3783 BioCyc
Ensembl Genes ENSRNOG00000028598 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000029258 ENTREZGENE
  ENSRNOP00000029258.5 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000030348 ENTREZGENE
  ENSRNOT00000030348.7 UniProtKB/TrEMBL
Gene3D-CATH 1.10.533.10 UniProtKB/TrEMBL
InterPro DEATH-like UniProtKB/TrEMBL
  EDAR_N UniProtKB/TrEMBL
KEGG Report rno:365581 UniProtKB/TrEMBL
NCBI Gene 365581 ENTREZGENE
PhenoGen Edar PhenoGen
Superfamily-SCOP DEATH_like UniProtKB/TrEMBL
UniProt D3ZGP2 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2013-05-24 Edar  ectodysplasin-A receptor  LOC678867  similar to Tumor necrosis factor receptor superfamily member EDAR precursor (Anhidrotic ectodysplasin receptor 1) (Ectodysplasin-A receptor) (Ectodermal dysplasia receptor) (Downless)  Data Merged 1643240 APPROVED
2008-02-29 Edar  ectodysplasin-A receptor  RGD1561714_predicted  similar to Ectodysplasin-A receptor (predicted)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-11-20 LOC678867  similar to Tumor necrosis factor receptor superfamily member EDAR precursor (Anhidrotic ectodysplasin receptor 1) (Ectodysplasin-A receptor) (Ectodermal dysplasia receptor) (Downless)      Symbol and Name status set to provisional 70820 PROVISIONAL
2006-03-07 RGD1561714_predicted  similar to Ectodysplasin-A receptor (predicted)  LOC365581  similar to Ectodysplasin-A receptor  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC365581  similar to Ectodysplasin-A receptor      Symbol and Name status set to provisional 70820 PROVISIONAL