Gene: Cbs (cystathionine beta synthase) Rattus norvegicus
Symbol: Cbs
Name: cystathionine beta synthase
Description: Exhibits cystathionine beta-synthase activity. Involved in several processes, including cellular response to hypoxia; hydrogen sulfide biosynthetic process; and transsulfuration. Predicted to localize to the cytoplasm and nucleus. Biomarker of hyperhomocysteinemia. Human ortholog(s) of this gene implicated in coronary artery disease; homocystinuria; and neural tube defect. Orthologous to several human genes including CBSL (cystathionine-beta-synthase like); PARTICIPATES IN cysteine metabolic pathway; transsulfuration pathway of homocysteine metabolism; cystathioninuria pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene; bisphenol A.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: beta-thionase; cystathionine beta-synthase; cystathionine-beta-synthase; hemoprotein H-450; serine sulfhydrase
Homo sapiens (human) : CBS (cystathionine-beta-synthase)  HGNC  Alliance
Mus musculus (house mouse) : Cbs (cystathionine beta-synthase)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Cbs (cystathionine-beta-synthase)
Pan paniscus (bonobo/pygmy chimpanzee) : CBS (cystathionine-beta-synthase)
Canis lupus familiaris (dog) : CBS (cystathionine-beta-synthase)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Cbs (cystathionine-beta-synthase)
Sus scrofa (pig) : CBS (cystathionine-beta-synthase)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.02010,361,987 - 10,386,663 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.02012,549,959 - 12,574,111 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42010,047,478 - 10,075,520 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.12010,047,871 - 10,075,744 (-)NCBI
Celera2011,221,836 - 11,246,354 (-)NCBICelera
Cytogenetic Map20p12NCBI
RH 3.4 Map20114.36RGD
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated
RGD Disease Portals


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 5.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Cbs
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 2287
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2019-04-23
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.