Cbs (cystathionine beta synthase) - Rat Genome Database

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Gene: Cbs (cystathionine beta synthase) Rattus norvegicus
Analyze
Symbol: Cbs
Name: cystathionine beta synthase
RGD ID: 2287
Description: Enables cystathionine beta-synthase activity. Involved in several processes, including cellular response to hypoxia; hydrogen sulfide biosynthetic process; and transsulfuration. Predicted to be located in nucleus. Predicted to be active in cytoplasm. Biomarker of hyperhomocysteinemia and vitamin B12 deficiency. Human ortholog(s) of this gene implicated in coronary artery disease; homocystinuria; hyperhomocysteinemia; malaria; and neural tube defect. Orthologous to human CBS (cystathionine beta-synthase); PARTICIPATES IN cysteine metabolic pathway; transsulfuration pathway of homocysteine metabolism; cystathioninuria pathway; INTERACTS WITH (+)-schisandrin B; 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: beta-thionase; cystathionine beta-synthase; cystathionine-beta-synthase; hemoprotein H-450; serine sulfhydrase
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2209,708,089 - 9,732,623 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl209,708,090 - 9,732,764 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2010,408,753 - 10,433,368 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0209,769,935 - 9,794,554 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.02010,239,612 - 10,263,909 (-)NCBIRnor_WKY
Rnor_6.02010,361,987 - 10,386,663 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2010,361,988 - 10,386,751 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02012,549,959 - 12,574,111 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42010,047,478 - 10,075,520 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12010,047,871 - 10,075,744 (-)NCBI
Celera2011,221,836 - 11,246,354 (-)NCBICelera
RH 3.4 Map20114.36RGD
Cytogenetic Map20p12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
(1->4)-beta-D-glucan  (ISO)
1-nitropyrene  (ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2,4-dinitrotoluene  (EXP)
2-hydroxypropanoic acid  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenylacetic acid  (ISO)
5-fluorouracil  (ISO)
acetamide  (EXP)
acrolein  (ISO)
acrylonitrile  (EXP)
aflatoxin B1  (ISO)
aldehydo-D-glucose  (EXP,ISO)
all-trans-retinoic acid  (ISO)
alpha-pinene  (ISO)
amino acid  (EXP)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
avobenzone  (ISO)
azoxystrobin  (EXP)
Benoxacor  (ISO)
benzo[a]pyrene  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
Brodifacoum  (EXP)
butan-1-ol  (ISO)
caffeine  (ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
carbonates  (ISO)
chlordecone  (ISO)
chlorpyrifos  (EXP)
choline  (ISO)
cisplatin  (ISO)
clofibric acid  (EXP)
cobalt dichloride  (EXP)
copper atom  (EXP)
copper(0)  (EXP)
copper(II) sulfate  (ISO)
Cuprizon  (EXP)
cyanocob(III)alamin  (EXP)
cyclosporin A  (ISO)
D-glucose  (EXP,ISO)
deoxynivalenol  (ISO)
diclofenac  (ISO)
dioxygen  (ISO)
disodium selenite  (ISO)
dorsomorphin  (ISO)
endosulfan  (EXP)
entinostat  (ISO)
enzyme inhibitor  (ISO)
ethanol  (ISO)
fenthion  (ISO)
folic acid  (EXP,ISO)
formaldehyde  (EXP,ISO)
gallic acid  (ISO)
glucose  (EXP,ISO)
glutathione  (ISO)
glyphosate  (EXP)
homocysteine  (EXP,ISO)
hydrogen sulfide  (EXP,ISO)
hydroquinone  (ISO)
hydroxylamine  (EXP)
imidacloprid  (EXP)
indometacin  (ISO)
inulin  (ISO)
L-ascorbic acid  (ISO)
L-cysteine  (ISO)
L-methionine  (ISO)
lipopolysaccharide  (ISO)
manganese(II) chloride  (EXP)
methapyrilene  (EXP)
methidathion  (ISO)
methionine  (EXP)
methyl methanesulfonate  (ISO)
methylmercury chloride  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
Monobutylphthalate  (ISO)
Muraglitazar  (EXP)
N-acetyl-L-cysteine  (ISO)
N-methyl-4-phenylpyridinium  (EXP,ISO)
N-nitrosodiethylamine  (EXP)
N-nitrosomorpholine  (EXP)
nickel dichloride  (EXP)
nitrogen dioxide  (ISO)
ozone  (ISO)
paracetamol  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
peroxynitrous acid  (ISO)
phenobarbital  (EXP,ISO)
phenylhydrazine  (EXP)
pirinixic acid  (EXP,ISO)
potassium dichromate  (ISO)
progesterone  (ISO)
propiconazole  (ISO)
Propiverine  (EXP)
prostaglandin E2  (ISO)
quercetin  (ISO)
rac-lactic acid  (ISO)
reactive oxygen species  (EXP)
resveratrol  (EXP,ISO)
rotenone  (ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
simvastatin  (ISO)
sodium arsenite  (EXP,ISO)
streptozocin  (ISO)
sunitinib  (ISO)
superoxide  (ISO)
tert-butyl hydroperoxide  (ISO)
Tesaglitazar  (EXP)
testosterone  (ISO)
tetrachloroethene  (ISO)
tetrachloromethane  (EXP,ISO)
tetracycline  (ISO)
thiabendazole  (EXP)
thioacetamide  (EXP)
trichloroethene  (EXP)
trichostatin A  (ISO)
triphenyl phosphate  (EXP)
triptonide  (ISO)
troglitazone  (EXP)
trovafloxacin  (ISO)
tunicamycin  (ISO)
valproic acid  (ISO)
vancomycin  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IBA,IEA,ISO,ISS)
cytosol  (TAS)
nucleus  (ISO,ISS)

References

References - curated
# Reference Title Reference Citation
1. Gene-gene interaction between the cystathionine beta-synthase 31 base pair variable number of tandem repeats and the methylenetetrahydrofolate reductase 677C > T polymorphism on homocysteine levels and risk for neural tube defects. Afman LA, etal., Mol Genet Metab. 2003 Mar;78(3):211-5.
2. Effect of endotoxemia in mice genetically deficient in cystathionine-γ-lyase, cystathionine-β-synthase or 3-mercaptopyruvate sulfurtransferase. Ahmad A, etal., Int J Mol Med. 2016 Dec;38(6):1683-1692. doi: 10.3892/ijmm.2016.2771. Epub 2016 Oct 14.
3. Methionine adenosyltransferase, cystathionine beta-synthase and cystathionine gamma-lyase activity of rat liver subcellular particles, human blood cells and mixed white cells from rat bone marrow. Allsop J and Watts RW, Clin Sci Mol Med Suppl. 1975 Jun;48(6):509-13.
4. Inhibition of endogenous hydrogen sulfide formation reduces the organ injury caused by endotoxemia. Collin M, etal., Br J Pharmacol. 2005 Oct;146(4):498-505. doi: 10.1038/sj.bjp.0706367.
5. Effect of vitamin B12-deficiency on the activity of hepatic cystathionine beta-synthase in rats. Doi T, etal., J Nutr Sci Vitaminol (Tokyo). 1989 Apr;35(2):101-10. doi: 10.3177/jnsv.35.101.
6. The effect of troglitazone on plasma homocysteine, hepatic and red blood cell S-adenosyl methionine, and S-adenosyl homocysteine and enzymes in homocysteine metabolism in Zucker rats. Fonseca V, etal., Metabolism. 2002 Jun;51(6):783-6. doi: 10.1053/meta.2002.32731.
7. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
8. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
9. Characterization of homocysteine metabolism in the rat kidney. House JD, etal., Biochem J 1997 Nov 15;328 ( Pt 1):287-92.
10. Molecular basis of cystathionine beta-synthase deficiency in pyridoxine responsive and nonresponsive homocystinuria. Hu FL, etal., Hum Mol Genet. 1993 Nov;2(11):1857-60.
11. Molecular cloning and sequence analysis of cDNA coding for rat liver hemoprotein H-450. Ishihara S, etal., J Biochem (Tokyo) 1990 Dec;108(6):899-902.
12. Genetic variants of homocysteine metabolizing enzymes and the risk of coronary artery disease. Janosikova B, etal., Mol Genet Metab. 2003 Jul;79(3):167-75.
13. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
14. High-density rat radiation hybrid maps containing over 24,000 SSLPs, genes, and ESTs provide a direct link to the rat genome sequence. Kwitek AE, etal., Genome Res. 2004 Apr;14(4):750-7
15. Hyperhomocysteinemia associated with decreased renal transsulfuration activity in Dahl S rats. Li N, etal., Hypertension. 2006 Jun;47(6):1094-100. Epub 2006 Apr 24.
16. Vitamin B-6 deficiency in rats reduces hepatic serine hydroxymethyltransferase and cystathionine beta-synthase activities and rates of in vivo protein turnover, homocysteine remethylation and transsulfuration. Martinez M, etal., J Nutr 2000 May;130(5):1115-23.
17. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
18. Possible selection of host folate pathway gene polymorphisms in patients with malaria from a malaria endemic region in North East India. Mirgal D, etal., Trans R Soc Trop Med Hyg. 2016 May;110(5):294-8. doi: 10.1093/trstmh/trw026.
19. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
20. High casein diet decreases plasma homocysteine concentration in rats. Ohuchi S, etal., J Nutr Sci Vitaminol (Tokyo). 2009 Feb;55(1):22-30.
21. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
22. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
23. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
24. Hormonal regulation of cystathionine beta-synthase expression in liver. Ratnam S, etal., J Biol Chem 2002 Nov 8;277(45):42912-8.
25. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
26. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
27. Comprehensive gene review and curation RGD comprehensive gene curation
28. Hydrogen sulfide stimulates Mycobacterium tuberculosis respiration, growth and pathogenesis. Saini V, etal., Nat Commun. 2020 Jan 28;11(1):557. doi: 10.1038/s41467-019-14132-y.
29. Polymorphisms of cystathionine beta-synthase gene are associated with susceptibility to sepsis. Sponholz C, etal., Eur J Hum Genet. 2016 Jul;24(7):1041-8. doi: 10.1038/ejhg.2015.231. Epub 2015 Oct 28.
30. Dealing with methionine/homocysteine sulfur: cysteine metabolism to taurine and inorganic sulfur. Stipanuk MH and Ueki I, J Inherit Metab Dis. 2011 Feb;34(1):17-32. doi: 10.1007/s10545-009-9006-9. Epub 2010 Feb 17.
31. Rat cystathionine beta-synthase. Gene organization and alternative splicing. Swaroop M, etal., J Biol Chem 1992 Jun 5;267(16):11455-61.
32. Hydrogen sulfide protects neurons against hypoxic injury via stimulation of ATP-sensitive potassium channel/protein kinase C/extracellular signal-regulated kinase/heat shock protein 90 pathway. Tay AS, etal., Neuroscience. 2010 May 5;167(2):277-86. doi: 10.1016/j.neuroscience.2010.02.006. Epub 2010 Feb 8.
33. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
34. Polygenic influence on plasma homocysteine: association of two prevalent mutations, the 844ins68 of cystathionine beta-synthase and A(2756)G of methionine synthase, with lowered plasma homocysteine levels. Tsai MY, etal., Atherosclerosis. 2000 Mar;149(1):131-7. doi: 10.1016/s0021-9150(99)00297-x.
35. Tetrahydrocurcumin ameliorates homocysteinylated cytochrome-c mediated autophagy in hyperhomocysteinemia mice after cerebral ischemia. Tyagi N, etal., J Mol Neurosci. 2012 May;47(1):128-38. doi: 10.1007/s12031-011-9695-z. Epub 2012 Jan 3.
36. CBS and CSE are critical for maintenance of mitochondrial function and glucocorticoid production in adrenal cortex. Wang CN, etal., Antioxid Redox Signal. 2014 Dec 1;21(16):2192-207. doi: 10.1089/ars.2013.5682. Epub 2014 May 27.
37. Hydrogen sulfide improves colonic barrier integrity in DSS-induced inflammation in Caco-2 cells and mice. Zhao H, etal., Int Immunopharmacol. 2016 Oct;39:121-127. doi: 10.1016/j.intimp.2016.07.020. Epub 2016 Jul 26.
38. Upregulation of cystathionine β-synthetase in the arcuate nucleus produces pain hypersensitivity via PKC upregulation and GluN2B phosphorylation in rats with chronic pancreatitis. Zheng H, etal., Sheng Li Xue Bao. 2016 Oct 25;68(5):575-584.
Additional References at PubMed
PMID:7878023   PMID:7929220   PMID:8854863   PMID:8889548   PMID:10953023   PMID:10993757   PMID:11483494   PMID:12433838   PMID:15030387   PMID:15131763   PMID:15520012   PMID:15555590  
PMID:15622513   PMID:15916860   PMID:16160063   PMID:16189514   PMID:16226235   PMID:16780588   PMID:16984962   PMID:17087506   PMID:18541157   PMID:18701635   PMID:18776696   PMID:19010420  
PMID:19439522   PMID:19447967   PMID:19776636   PMID:20031578   PMID:20392694   PMID:21900206   PMID:22891245   PMID:22985361   PMID:23249427   PMID:23273102   PMID:23285261   PMID:23858469  
PMID:23981774   PMID:24328859   PMID:24416422   PMID:24490955   PMID:24515102   PMID:24534463   PMID:24783194   PMID:25416956   PMID:25502805   PMID:25773343   PMID:25797494   PMID:25873304  
PMID:26229403   PMID:26241765   PMID:27465493   PMID:27904035   PMID:27905525   PMID:28656194   PMID:28750410   PMID:29102635   PMID:29712513   PMID:29804940   PMID:31515488   PMID:32184133  
PMID:35042677  


Genomics

Comparative Map Data
Cbs
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2209,708,089 - 9,732,623 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl209,708,090 - 9,732,764 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2010,408,753 - 10,433,368 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0209,769,935 - 9,794,554 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.02010,239,612 - 10,263,909 (-)NCBIRnor_WKY
Rnor_6.02010,361,987 - 10,386,663 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2010,361,988 - 10,386,751 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02012,549,959 - 12,574,111 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42010,047,478 - 10,075,520 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12010,047,871 - 10,075,744 (-)NCBI
Celera2011,221,836 - 11,246,354 (-)NCBICelera
RH 3.4 Map20114.36RGD
Cytogenetic Map20p12NCBI
CBS
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382143,053,191 - 43,076,873 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl2143,053,191 - 43,076,943 (-)EnsemblGRCh38hg38GRCh38
GRCh372144,473,301 - 44,496,983 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362143,346,370 - 43,369,490 (-)NCBINCBI36Build 36hg18NCBI36
Build 342143,346,369 - 43,369,493NCBI
Celera2129,625,968 - 29,649,139 (-)NCBICelera
Cytogenetic Map21q22.3NCBI
HuRef2129,891,797 - 29,914,621 (-)NCBIHuRef
CHM1_12144,034,200 - 44,057,328 (-)NCBICHM1_1
T2T-CHM13v2.02141,444,310 - 41,468,059 (-)NCBIT2T-CHM13v2.0
Cbs
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391731,831,602 - 31,856,170 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1731,827,868 - 31,856,212 (-)EnsemblGRCm39 Ensembl
GRCm381731,612,623 - 31,637,233 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1731,608,894 - 31,637,238 (-)EnsemblGRCm38mm10GRCm38
MGSCv371731,749,589 - 31,774,086 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361731,341,354 - 31,365,851 (-)NCBIMGSCv36mm8
Celera1732,529,962 - 32,554,408 (-)NCBICelera
Cytogenetic Map17B1NCBI
cM Map1716.93NCBI
Cbs
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540738,924,321 - 38,939,790 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495540738,924,355 - 38,939,790 (+)NCBIChiLan1.0ChiLan1.0
CBS
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan12133,962,881 - 33,987,091 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02129,361,519 - 29,385,610 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12142,670,530 - 42,693,300 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2142,670,530 - 42,690,932 (-)Ensemblpanpan1.1panPan2
CBS
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13137,230,900 - 37,247,170 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3136,381,153 - 36,399,797 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03136,773,609 - 36,792,296 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3136,773,643 - 36,792,300 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13136,640,852 - 36,659,539 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03136,620,580 - 36,639,238 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03137,118,109 - 37,136,774 (-)NCBIUU_Cfam_GSD_1.0
Cbs
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440497136,464,257 - 36,490,204 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936500987,128 - 1,003,388 (+)EnsemblSpeTri2.0
SpeTri2.0NW_004936500976,043 - 1,003,559 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CBS
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl13206,205,946 - 206,230,248 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.113206,205,942 - 206,231,363 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
LOC103221104
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1286,905,104 - 86,933,780 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366605414,889,500 - 14,930,985 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Cbs
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474527,673,748 - 27,688,462 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474527,676,430 - 27,687,573 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Cbs
124 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:462
Count of miRNA genes:226
Interacting mature miRNAs:270
Transcripts:ENSRNOT00000042432, ENSRNOT00000045275, ENSRNOT00000048219
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1354642Despr15Despair related QTL 150.0027locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)20124159021Rat
1600382Edcs3Endometrial carcinoma susceptibility QTL33.50.003uterus morphology trait (VT:0001120)percentage of study population developing endometrioid carcinoma during a period of time (CMO:0001759)20125159026Rat
2317851Alcrsp22Alcohol response QTL 223.20.05response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)20127339237Rat
1641893Alcrsp7Alcohol response QTL 7response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)20127339237Rat
8694189Bw153Body weight QTL 1533.130.001body mass (VT:0001259)body weight gain (CMO:0000420)20129191651Rat
9590275Scort15Serum corticosterone level QTL 153.480.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)20129191651Rat
7411650Foco23Food consumption QTL 2320.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)20129191651Rat
9590109Sffal8Serum free fatty acids level QTL 85.320.01blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)20129191651Rat
9589155Insul32Insulin level QTL 326.380.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)20129191651Rat
6893685Bw111Body weight QTL 1112.70.004body mass (VT:0001259)body weight (CMO:0000012)20132578807Rat
7411668Foco32Food consumption QTL 3280.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)20136600972Rat
9590252Scort12Serum corticosterone level QTL 1220.460.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)20136600972Rat
2305926Iddm37Insulin dependent diabetes mellitus QTL 376blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)20152784246527842Rat
1641915Colcr9Colorectal carcinoma resistance QTL 92.970.0024intestine integrity trait (VT:0010554)benign colorectal tumor number (CMO:0001795)20153065546530655Rat
1598816Memor12Memory QTL 122.4exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)20260683647606836Rat
2317057Aia27Adjuvant induced arthritis QTL 272.83joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)20289259726381954Rat
1331772Cdexp2CD45RC expression in CD8 T cells QTL 25.7CD8-positive T cell quantity (VT:0008077)blood CD45RC(high) CD8 T cell count to CD45RC(low) CD8 T cell count ratio (CMO:0001990)20362164910078919Rat
61432Cia1Collagen induced arthritis QTL 1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)20362165614101050Rat
4889857Pur27Proteinuria QTL 2712.20.001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)20460660717617956Rat
1558640Prcs2Prostate cancer susceptibility QTL 23.3prostate integrity trait (VT:0010571)percentage of study population developing ventral prostate tumorous lesions during a period of time (CMO:0000943)20460660717617956Rat
70154Insul2Insulin level QTL 23.75blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)20669170617489458Rat
1581577Pur15Proteinuria QTL 154.380.0002urine total protein amount (VT:0000032)urine protein excretion rate (CMO:0000759)20804241017617956Rat
4889870Pur30Proteinuria QTL 30190.005urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)20804241029322208Rat
631265Iresp1Immunoglobin response QTL18.3blood anti-double stranded DNA antibody amount (VT:0004762)serum anti-DNA antibody level (CMO:0001533)20903971913461775Rat

Markers in Region
RH94498  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2209,708,261 - 9,708,440 (+)MAPPERmRatBN7.2
Rnor_6.02010,362,160 - 10,362,338NCBIRnor6.0
Rnor_5.02012,550,132 - 12,550,310UniSTSRnor5.0
RGSC_v3.42010,047,651 - 10,047,829UniSTSRGSC3.4
Celera2011,222,009 - 11,222,187UniSTS
RH 3.4 Map20114.36UniSTS
Cytogenetic Map20p12UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 2 29 29 29 37 35 6
Low 1 36 28 12 19 12 4 6 35 32 11 4
Below cutoff 7 4 5 2 3 4

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000042432   ⟹   ENSRNOP00000039968
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl209,708,259 - 9,732,764 (-)Ensembl
Rnor_6.0 Ensembl2010,362,172 - 10,386,751 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000045275   ⟹   ENSRNOP00000042958
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl209,708,090 - 9,732,623 (-)Ensembl
Rnor_6.0 Ensembl2010,361,988 - 10,386,663 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000105994   ⟹   ENSRNOP00000091719
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl209,708,259 - 9,732,764 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000116783   ⟹   ENSRNOP00000082078
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl209,708,259 - 9,729,401 (-)Ensembl
RefSeq Acc Id: NM_012522   ⟹   NP_036654
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2209,708,089 - 9,732,623 (-)NCBI
Rnor_6.02010,361,987 - 10,386,663 (-)NCBI
Rnor_5.02012,549,959 - 12,574,111 (-)NCBI
RGSC_v3.42010,047,478 - 10,075,520 (-)RGD
Celera2011,221,836 - 11,246,354 (-)RGD
Sequence:
Reference Sequences
RefSeq Acc Id: NP_036654   ⟸   NM_012522
- UniProtKB: P32232 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSRNOP00000042958   ⟸   ENSRNOT00000045275
RefSeq Acc Id: ENSRNOP00000039968   ⟸   ENSRNOT00000042432
RefSeq Acc Id: ENSRNOP00000091719   ⟸   ENSRNOT00000105994
RefSeq Acc Id: ENSRNOP00000082078   ⟸   ENSRNOT00000116783
Protein Domains
CBS

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P32232-F1-model_v2 AlphaFold P32232 1-561 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13701478
Promoter ID:EPDNEW_R12001
Type:multiple initiation site
Name:Cbs_1
Description:cystathionine beta synthase
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.02010,386,719 - 10,386,779EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2287 AgrOrtholog
BioCyc Gene G2FUF-4306 BioCyc
BioCyc Pathway HOMOCYSDEGR-PWY [L-cysteine biosynthesis III (from L-homocysteine)] BioCyc
  PWY66-426 [hydrogen sulfide biosynthesis II (mammalian)] BioCyc
Ensembl Genes ENSRNOG00000029528 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000039968.4 UniProtKB/Swiss-Prot
  ENSRNOP00000042958 ENTREZGENE
  ENSRNOP00000042958.3 UniProtKB/Swiss-Prot
  ENSRNOP00000082078.1 UniProtKB/Swiss-Prot
  ENSRNOP00000091719.1 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000042432.7 UniProtKB/Swiss-Prot
  ENSRNOT00000045275 ENTREZGENE
  ENSRNOT00000045275.6 UniProtKB/Swiss-Prot
  ENSRNOT00000105994.1 UniProtKB/TrEMBL
  ENSRNOT00000116783.1 UniProtKB/Swiss-Prot
Gene3D-CATH 3.10.580.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.40.50.1100 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro CBS_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CBS_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CBS_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cysta_beta_synth UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  P-phosphate_BS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PLP-dep UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Trypto_synt_PLP_dependent UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:24250 UniProtKB/Swiss-Prot
NCBI Gene 24250 ENTREZGENE
PANTHER CYSTATHIONINE BETA-SYNTHASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CYSTATHIONINE BETA-SYNTHASE-RELATED UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam CBS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PALP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB CBS RGD
PhenoGen Cbs PhenoGen
PROSITE CBS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CYS_SYNTHASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART CBS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF53686 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF54631 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGR TC208753
TIGRFAMs cysta_beta UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8I6AE71_RAT UniProtKB/TrEMBL
  CBS_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-06-10 Cbs  Cystathionine beta synthase      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression expressed in liver 634704
gene_function catalyzes the condensation of serine and homocysteine to cystathionine 634704
gene_process key enzyme involved in the transsulfuration pathway 634704
gene_regulation activity is regulated by insulin 634704
gene_transcript alternative splicing produces four distinct mRNA transcripts 1299859