Nodal (nodal growth differentiation factor) - Rat Genome Database

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Gene: Nodal (nodal growth differentiation factor) Rattus norvegicus
Analyze
Symbol: Nodal
Name: nodal growth differentiation factor
RGD ID: 1305994
Description: Predicted to enable cytokine activity and type I activin receptor binding activity. Involved in female pregnancy. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Human ortholog(s) of this gene implicated in visceral heterotaxy. Orthologous to human NODAL (nodal growth differentiation factor); PARTICIPATES IN transforming growth factor-beta superfamily mediated signaling pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; bisphenol A; paracetamol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: LOC294503; nodal homolog; nodal homolog (mouse)
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.22029,368,436 - 29,376,837 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2029,368,436 - 29,376,837 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2030,384,407 - 30,392,808 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.02029,770,653 - 29,779,054 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.02030,513,159 - 30,521,560 (+)NCBIRnor_WKY
Rnor_6.02031,035,729 - 31,044,096 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2031,035,729 - 31,044,096 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02032,822,880 - 32,831,247 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42029,546,982 - 29,555,419 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12029,560,988 - 29,568,536 (+)NCBI
Celera2030,797,163 - 30,805,518 (+)NCBICelera
Cytogenetic Map20q11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
anatomical structure formation involved in morphogenesis  (ISO)
anterior/posterior axis specification  (ISO)
anterior/posterior pattern specification  (ISO)
axial mesodermal cell fate specification  (ISO)
BMP signaling pathway  (IBA)
brain development  (ISO)
cell differentiation  (ISO)
cell fate commitment  (ISO)
cell migration  (ISO)
cell migration involved in gastrulation  (ISO)
cell population proliferation  (ISO)
determination of left/right symmetry  (ISO)
digestive system development  (ISO)
digestive tract morphogenesis  (ISO)
embryonic cranial skeleton morphogenesis  (ISO)
embryonic heart tube development  (ISO)
embryonic pattern specification  (ISO)
embryonic placenta development  (ISO)
embryonic process involved in female pregnancy  (ISO)
endoderm development  (ISO)
endodermal cell differentiation  (ISO)
epiblast cell-extraembryonic ectoderm cell signaling involved in anterior/posterior axis specification  (ISO)
female pregnancy  (IEP)
floor plate morphogenesis  (ISO)
formation of anatomical boundary  (ISO)
gastrulation  (ISO)
gastrulation with mouth forming second  (ISO)
germ cell development  (ISO)
heart development  (ISO)
heart looping  (ISO)
in utero embryonic development  (ISO)
inhibition of neuroepithelial cell differentiation  (ISO)
left lung morphogenesis  (ISO)
liver development  (ISO)
lung development  (ISO)
maternal placenta development  (ISO)
maternal process involved in parturition  (ISO)
mesendoderm development  (ISO)
mesoderm formation  (ISO)
negative regulation of androgen receptor signaling pathway  (ISO)
negative regulation of cell development  (ISO)
negative regulation of cell differentiation  (ISO)
negative regulation of chorionic trophoblast cell proliferation  (ISO)
negative regulation of reproductive process  (ISO)
negative regulation of transcription by RNA polymerase II  (ISO)
negative regulation of trophoblast cell migration  (ISO)
nervous system development  (ISO)
neural fold formation  (ISO)
nodal signaling pathway  (ISO)
nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry  (ISO)
placenta development  (ISO)
polarity specification of proximal/distal axis  (ISO)
positive regulation of activin receptor signaling pathway  (ISO)
positive regulation of angiogenesis  (ISO)
positive regulation of cell population proliferation  (ISO)
positive regulation of cell-cell adhesion  (ISO)
positive regulation of cysteine-type endopeptidase activity involved in apoptotic process  (ISO)
positive regulation of DNA-binding transcription factor activity  (ISO)
positive regulation of epithelial cell proliferation  (ISO)
positive regulation of ERK1 and ERK2 cascade  (ISO)
positive regulation of pathway-restricted SMAD protein phosphorylation  (IBA,ISO)
positive regulation of SMAD protein signal transduction  (ISO)
positive regulation of transcription by RNA polymerase II  (ISO)
positive regulation of vascular endothelial growth factor production  (ISO)
primitive streak formation  (ISO)
regulation of gastrulation  (ISO)
regulation of signal transduction  (ISO)
SMAD protein signal transduction  (IBA,ISO)
somatic stem cell population maintenance  (ISO)
stem cell population maintenance  (ISO)
tissue morphogenesis  (ISO)
transforming growth factor beta receptor signaling pathway involved in primitive streak formation  (ISO)
trophectodermal cell differentiation  (ISO)
trophectodermal cellular morphogenesis  (ISO)
vasculature development  (ISO)

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Embryo presence regulates NODAL/LEFTY2 system in the rat oviduct in vivo. ArgaƱaraz ME, etal., Mol Reprod Dev. 2019 Nov;86(11):1652-1662. doi: 10.1002/mrd.23254. Epub 2019 Aug 16.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
4. Identification and functional characterization of NODAL rare variants in heterotaxy and isolated cardiovascular malformations. Mohapatra B, etal., Hum Mol Genet. 2009 Mar 1;18(5):861-71. doi: 10.1093/hmg/ddn411. Epub 2008 Dec 8.
5. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
6. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
7. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
8. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
9. ACVR2A promoter polymorphism rs1424954 in the Activin-A signaling pathway in trophoblasts. Thulluru HK, etal., Placenta. 2015 Apr;36(4):345-9. doi: 10.1016/j.placenta.2015.01.010. Epub 2015 Jan 26.
10. Nodal increases the malignancy of childhood neuroblastoma cells via regulation of Zeb1. Wu J, etal., Biofactors. 2019 May;45(3):355-363. doi: 10.1002/biof.1505. Epub 2019 Apr 15.
Additional References at PubMed
PMID:7924997   PMID:9420335   PMID:11311163   PMID:11418863   PMID:11456449   PMID:12052855   PMID:12231623   PMID:12642485   PMID:12654299   PMID:12842913   PMID:14511481   PMID:14607953  
PMID:15004567   PMID:15150278   PMID:15302604   PMID:15466485   PMID:15485907   PMID:15505202   PMID:16496285   PMID:16678814   PMID:16709598   PMID:17507406   PMID:17568773   PMID:17936261  
PMID:20040491   PMID:21116837   PMID:21356369   PMID:21445260   PMID:21656830   PMID:21741376   PMID:22378764   PMID:22550067   PMID:23034635   PMID:28182636   PMID:31298343   PMID:34737126  


Genomics

Comparative Map Data
Nodal
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.22029,368,436 - 29,376,837 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2029,368,436 - 29,376,837 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2030,384,407 - 30,392,808 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.02029,770,653 - 29,779,054 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.02030,513,159 - 30,521,560 (+)NCBIRnor_WKY
Rnor_6.02031,035,729 - 31,044,096 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2031,035,729 - 31,044,096 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02032,822,880 - 32,831,247 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42029,546,982 - 29,555,419 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12029,560,988 - 29,568,536 (+)NCBI
Celera2030,797,163 - 30,805,518 (+)NCBICelera
Cytogenetic Map20q11NCBI
NODAL
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381070,431,936 - 70,447,951 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl1070,431,936 - 70,447,951 (-)EnsemblGRCh38hg38GRCh38
GRCh371072,191,692 - 72,207,707 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361071,862,077 - 71,871,429 (-)NCBINCBI36Build 36hg18NCBI36
Build 341071,862,076 - 71,871,429NCBI
Celera1065,472,123 - 65,481,898 (-)NCBICelera
Cytogenetic Map10q22.1NCBI
HuRef1066,185,532 - 66,195,306 (-)NCBIHuRef
CHM1_11072,473,912 - 72,483,685 (-)NCBICHM1_1
T2T-CHM13v2.01071,301,367 - 71,317,383 (-)NCBIT2T-CHM13v2.0
Nodal
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391061,253,751 - 61,261,117 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1061,253,751 - 61,261,117 (+)EnsemblGRCm39 Ensembl
GRCm381061,417,972 - 61,425,338 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1061,417,972 - 61,425,338 (+)EnsemblGRCm38mm10GRCm38
MGSCv371060,880,720 - 60,888,085 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361060,813,657 - 60,819,993 (+)NCBIMGSCv36mm8
Celera1062,519,279 - 62,526,659 (+)NCBICelera
Cytogenetic Map10B4NCBI
cM Map1032.21NCBI
Nodal
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543720,828,448 - 20,835,628 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495543720,828,448 - 20,835,486 (+)NCBIChiLan1.0ChiLan1.0
NODAL
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11069,433,959 - 69,443,972 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1069,433,959 - 69,443,972 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01066,906,866 - 66,916,938 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
NODAL
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1421,366,828 - 21,374,623 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl421,367,583 - 21,375,151 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha421,499,043 - 21,506,382 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0421,641,721 - 21,649,105 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl421,641,856 - 21,649,745 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1421,539,356 - 21,546,535 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0421,744,769 - 21,751,938 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0422,096,050 - 22,103,419 (-)NCBIUU_Cfam_GSD_1.0
Nodal
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440721359,674,355 - 59,686,268 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365218,171,146 - 8,178,705 (+)EnsemblSpeTri2.0
SpeTri2.0NW_0049365218,171,146 - 8,178,802 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NODAL
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1473,353,258 - 73,360,654 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11473,350,358 - 73,357,064 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
NODAL
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1960,852,567 - 60,863,225 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl960,853,763 - 60,862,839 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604821,593,182 - 21,609,737 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Nodal
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247544,557,952 - 4,564,644 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247544,557,407 - 4,564,580 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Nodal
53 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:435
Count of miRNA genes:230
Interacting mature miRNAs:274
Transcripts:ENSRNOT00000000672
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
6893685Bw111Body weight QTL 1112.70.004body mass (VT:0001259)body weight (CMO:0000012)20132578807Rat
7411668Foco32Food consumption QTL 3280.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)20136600972Rat
9590252Scort12Serum corticosterone level QTL 1220.460.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)20136600972Rat
2305926Iddm37Insulin dependent diabetes mellitus QTL 376blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)20152784246527842Rat
1641915Colcr9Colorectal carcinoma resistance QTL 92.970.0024intestine integrity trait (VT:0010554)benign colorectal tumor number (CMO:0001795)20153065546530655Rat
1598816Memor12Memory QTL 122.4exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)20260683647606836Rat
7411652Foco24Food consumption QTL 240.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)201175751554435887Rat
9590092Insglur9Insulin/glucose ratio QTL 918.380.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)201175751554435887Rat
4889610Pancm3Pancreatic morphology QTL 33.750.001pancreas mass (VT:0010144)pancreas wet weight (CMO:0000626)201761783247606836Rat
2317880Alcrsp25Alcohol response QTL 252.3response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)201769755054435887Rat
2303626Vencon10Ventilatory control QTL 100.001respiration trait (VT:0001943)respiration rate (CMO:0000289)201919072154435887Rat
2303578Gluco50Glucose level QTL 502blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)202510672254435887Rat
2303587Bw93Body weight QTL 9313body mass (VT:0001259)body weight (CMO:0000012)202510672254435887Rat
2300188Bmd68Bone mineral density QTL 686.40.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)202510672254435887Rat
1331747Hrtrt16Heart rate QTL 163.163heart pumping trait (VT:2000009)heart rate (CMO:0000002)202520973454435887Rat
1598869Memor6Memory QTL 63.1exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)202924438854435887Rat

Markers in Region
Nodal  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22029,375,222 - 29,376,136 (+)MAPPERmRatBN7.2
Rnor_6.02031,042,482 - 31,043,395NCBIRnor6.0
Rnor_5.02032,829,633 - 32,830,546UniSTSRnor5.0
RGSC_v3.42029,553,805 - 29,554,718UniSTSRGSC3.4
Celera2030,803,904 - 30,804,817UniSTS
Cytogenetic Map20q11UniSTS
Nodal  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22029,375,150 - 29,376,079 (+)MAPPERmRatBN7.2
Rnor_6.02031,042,410 - 31,043,338NCBIRnor6.0
Rnor_5.02032,829,561 - 32,830,489UniSTSRnor5.0
Celera2030,803,832 - 30,804,760UniSTS
Cytogenetic Map20q11UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium
Low 8
Below cutoff 1 16 8 15 8 2 3 5 5 24 6 2

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000000672   ⟹   ENSRNOP00000000672
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2029,368,436 - 29,376,837 (+)Ensembl
Rnor_6.0 Ensembl2031,035,729 - 31,044,096 (+)Ensembl
RefSeq Acc Id: NM_001106394   ⟹   NP_001099864
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.22029,368,436 - 29,376,837 (+)NCBI
Rnor_6.02031,035,729 - 31,044,096 (+)NCBI
Rnor_5.02032,822,880 - 32,831,247 (+)NCBI
RGSC_v3.42029,546,982 - 29,555,419 (+)RGD
Celera2030,797,163 - 30,805,518 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001099864 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL93025 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_001099864   ⟸   NM_001106394
- Peptide Label: precursor
- UniProtKB: D3ZGK9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000000672   ⟸   ENSRNOT00000000672
Protein Domains
TGF_BETA_2

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZGK9-F1-model_v2 AlphaFold D3ZGK9 1-354 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1305994 AgrOrtholog
BioCyc Gene G2FUF-3723 BioCyc
Ensembl Genes ENSRNOG00000000556 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000000672 ENTREZGENE
  ENSRNOP00000000672.2 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000000672 ENTREZGENE
  ENSRNOT00000000672.5 UniProtKB/TrEMBL
Gene3D-CATH 2.10.90.10 UniProtKB/TrEMBL
InterPro Cystine-knot_cytokine UniProtKB/TrEMBL
  TGF-b_C UniProtKB/TrEMBL
  TGF-beta-rel UniProtKB/TrEMBL
  TGFb_CS UniProtKB/TrEMBL
KEGG Report rno:294503 UniProtKB/TrEMBL
NCBI Gene 294503 ENTREZGENE
PANTHER TGFbeta UniProtKB/TrEMBL
Pfam TGF_beta UniProtKB/TrEMBL
PhenoGen Nodal PhenoGen
PROSITE TGF_BETA_1 UniProtKB/TrEMBL
  TGF_BETA_2 UniProtKB/TrEMBL
SMART TGFB UniProtKB/TrEMBL
Superfamily-SCOP SSF57501 UniProtKB/TrEMBL
UniProt D3ZGK9 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2012-12-18 Nodal  nodal growth differentiation factor  Nodal  nodal homolog (mouse)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-09-26 Nodal  nodal homolog (mouse)  Nodal  nodal  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-03-11 Nodal  nodal  Nodal  nodal homolog (mouse)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-03-06 Nodal  nodal homolog (mouse)  Nodal_predicted  nodal homolog (mouse) (predicted)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-30 Nodal_predicted  nodal homolog (mouse) (predicted)    nodal (predicted)  Name updated 1299863 APPROVED
2005-01-12 Nodal_predicted  nodal (predicted)      Symbol and Name status set to approved 70820 APPROVED