RGD Reference Report - Embryo presence regulates NODAL/LEFTY2 system in the rat oviduct in vivo. - Rat Genome Database

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Embryo presence regulates NODAL/LEFTY2 system in the rat oviduct in vivo.

Authors: Argañaraz, Martin E  Zampini, Renato  Apichela, Silvana A  Barraza, Daniela E  Angiono, Georgina  Lombardo, Daniel 
Citation: Argañaraz ME, etal., Mol Reprod Dev. 2019 Nov;86(11):1652-1662. doi: 10.1002/mrd.23254. Epub 2019 Aug 16.
RGD ID: 155230829
Pubmed: PMID:31418961   (View Abstract at PubMed)
DOI: DOI:10.1002/mrd.23254   (Journal Full-text)

To gain further insight in the mechanisms of the embryo-maternal dialog in the oviduct, expression of members of the transforming growth factor-β superfamily, NODAL, its inhibitor, LEFTY2, and their coreceptor, CFC1, were studied in the oviduct of 3-day post copula (3 dpc) females with and without embryos (E and NE), pseudopregnant rats (SP3), and in 3-day embryos. Nodal transcripts in SP3 oviducts showed a steady-state relative abundance when compared with proestrus stage and the 3 dpc. In contrast, Lefty2 and Cfc1 relative abundance levels in proestrus and 3 dpc were higher. When comparing E with NE oviducts, Nodal and Lefty2 expression levels decreased, while Cfc1 expression increased in the presence of embryos. Nodal messenger RNA (mRNA) was observed in the embryo, but Lefty2 and Cfc1 transcripts were not found. In addition, an increase in Lefty2 expression coincided with increased levels of matrix metalloproteinases 9 mRNA and protein in the oviduct and in the oviductal fluid, respectively. These observations have shed new light on the relevance of the NODAL/LEFTY2 pathway in the oviduct during early embryo development and the role of the embryo in modulating this pathway.



Gene Ontology Annotations    Click to see Annotation Detail View

Biological Process

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
Cfc1Ratfemale pregnancy  IEP  RGD 
NodalRatfemale pregnancy  IEP  RGD 

Objects Annotated

Genes (Rattus norvegicus)
Cfc1  (cripto, FRL-1, cryptic family 1)
Nodal  (nodal growth differentiation factor)


Additional Information