NODAL (nodal growth differentiation factor) - Rat Genome Database

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Gene: NODAL (nodal growth differentiation factor) Sus scrofa
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Symbol: NODAL
Name: nodal growth differentiation factor
RGD ID: 14269058
Description: ENCODES a protein that exhibits receptor ligand activity (ortholog); INVOLVED IN anatomical structure formation involved in morphogenesis (ortholog); anterior/posterior axis specification (ortholog); anterior/posterior pattern specification (ortholog); ASSOCIATED WITH congenital heart disease (ortholog); Congenitally Corrected Transposition of the Great Arteries (ortholog); familial hemophagocytic lymphohistiocytosis 2 (ortholog); FOUND IN extracellular region (ortholog); extracellular space (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Also known as: nodal homolog
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Sscrofa11.1 - Pig Sscrofa11.1 Assembly
Position:
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1473,349,965 - 73,360,618 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11473,350,358 - 73,357,064 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
anatomical structure formation involved in morphogenesis  (ISO)
anterior/posterior axis specification  (ISO)
anterior/posterior pattern specification  (ISO)
axial mesodermal cell fate specification  (IEA,ISO)
BMP signaling pathway  (IBA)
brain development  (IEA,ISO)
cell fate commitment  (ISO)
cell migration  (ISO)
cell migration involved in gastrulation  (IEA,ISO)
determination of left/right symmetry  (ISO)
digestive system development  (ISO)
digestive tract morphogenesis  (IEA,ISO)
embryonic cranial skeleton morphogenesis  (IEA,ISO)
embryonic heart tube development  (ISO)
embryonic pattern specification  (IEA,ISO)
embryonic placenta development  (IEA,ISO)
embryonic process involved in female pregnancy  (IEA,ISO)
endoderm development  (ISO)
endodermal cell differentiation  (IEA)
epiblast cell-extraembryonic ectoderm cell signaling involved in anterior/posterior axis specification  (IEA,ISO)
floor plate morphogenesis  (IEA,ISO)
formation of anatomical boundary  (IEA,ISO)
gastrulation  (ISO)
gastrulation with mouth forming second  (ISO)
heart development  (ISO)
heart looping  (IEA,ISO)
in utero embryonic development  (ISO)
inhibition of neuroepithelial cell differentiation  (IEA,ISO)
left lung morphogenesis  (IEA,ISO)
liver development  (IEA,ISO)
lung development  (ISO)
maternal placenta development  (IEA,ISO)
maternal process involved in parturition  (IEA,ISO)
mesendoderm development  (IEA,ISO)
mesoderm formation  (ISO)
negative regulation of androgen receptor signaling pathway  (IEA)
negative regulation of cell development  (IEA,ISO)
negative regulation of cell differentiation  (ISO)
negative regulation of chorionic trophoblast cell proliferation  (IEA)
negative regulation of transcription by RNA polymerase II  (IEA,ISO)
negative regulation of trophoblast cell migration  (IEA)
nervous system development  (ISO)
neural fold formation  (IEA,ISO)
nodal signaling pathway  (ISO)
nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry  (IEA)
placenta development  (ISO)
polarity specification of proximal/distal axis  (IEA,ISO)
positive regulation of activin receptor signaling pathway  (IEA)
positive regulation of angiogenesis  (IEA)
positive regulation of cell population proliferation  (ISO)
positive regulation of cell-cell adhesion  (IEA)
positive regulation of cysteine-type endopeptidase activity involved in apoptotic process  (IEA)
positive regulation of DNA-binding transcription factor activity  (IEA)
positive regulation of epithelial cell proliferation  (IEA)
positive regulation of ERK1 and ERK2 cascade  (IEA)
positive regulation of pathway-restricted SMAD protein phosphorylation  (IBA)
positive regulation of SMAD protein signal transduction  (IEA)
positive regulation of transcription by RNA polymerase II  (IEA,ISO)
positive regulation of vascular endothelial growth factor production  (IEA)
primitive streak formation  (ISO)
regulation of gastrulation  (IEA,ISO)
regulation of signal transduction  (ISO)
SMAD protein signal transduction  (IBA,ISO)
stem cell population maintenance  (IEA,ISO)
tissue morphogenesis  (ISO)
transforming growth factor beta receptor signaling pathway involved in primitive streak formation  (IEA,ISO)
trophectodermal cell differentiation  (ISO)
trophectodermal cellular morphogenesis  (IEA,ISO)
vasculature development  (IEA,ISO)

Cellular Component

Molecular Function

References

Genomics

Comparative Map Data
NODAL
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1473,349,965 - 73,360,618 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11473,350,358 - 73,357,064 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
NODAL
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1070,431,936 - 70,447,951 (-)EnsemblGRCh38hg38GRCh38
GRCh381070,431,936 - 70,447,951 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371072,191,692 - 72,207,707 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361071,862,077 - 71,871,429 (-)NCBINCBI36hg18NCBI36
Build 341071,862,076 - 71,871,429NCBI
Celera1065,472,123 - 65,481,898 (-)NCBI
Cytogenetic Map10q22.1NCBI
HuRef1066,185,532 - 66,195,306 (-)NCBIHuRef
CHM1_11072,473,912 - 72,483,685 (-)NCBICHM1_1
Nodal
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391061,253,751 - 61,261,117 (+)NCBIGRCm39mm39
GRCm39 Ensembl1061,253,751 - 61,261,117 (+)Ensembl
GRCm381061,417,972 - 61,425,338 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1061,417,972 - 61,425,338 (+)EnsemblGRCm38mm10GRCm38
MGSCv371060,880,720 - 60,888,085 (+)NCBIGRCm37mm9NCBIm37
MGSCv361060,813,657 - 60,819,993 (+)NCBImm8
Celera1062,519,279 - 62,526,659 (+)NCBICelera
Cytogenetic Map10B4NCBI
cM Map1032.21NCBI
Nodal
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.22029,368,436 - 29,376,837 (+)NCBI
Rnor_6.0 Ensembl2031,035,729 - 31,044,096 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.02031,035,729 - 31,044,096 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.02032,822,880 - 32,831,247 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42029,546,982 - 29,555,419 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.12029,560,988 - 29,568,536 (+)NCBI
Celera2030,797,163 - 30,805,518 (+)NCBICelera
Cytogenetic Map20q11NCBI
Nodal
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543720,828,448 - 20,835,628 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495543720,828,448 - 20,835,486 (+)NCBIChiLan1.0ChiLan1.0
NODAL
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11069,433,959 - 69,443,972 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1069,433,959 - 69,443,972 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01066,906,866 - 66,916,938 (-)NCBIMhudiblu_PPA_v0panPan3
NODAL
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1421,366,828 - 21,374,623 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl421,367,583 - 21,375,151 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha421,499,043 - 21,506,382 (-)NCBI
ROS_Cfam_1.0421,641,721 - 21,649,105 (-)NCBI
UMICH_Zoey_3.1421,539,356 - 21,546,535 (-)NCBI
UNSW_CanFamBas_1.0421,744,769 - 21,751,938 (-)NCBI
UU_Cfam_GSD_1.0422,096,050 - 22,103,419 (-)NCBI
Nodal
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440721359,674,355 - 59,686,268 (+)NCBI
SpeTri2.0NW_0049365218,171,146 - 8,178,802 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NODAL
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1960,852,567 - 60,863,225 (+)NCBI
ChlSab1.1 Ensembl960,853,763 - 60,862,839 (+)Ensembl
Vero_WHO_p1.0NW_02366604821,593,182 - 21,609,737 (+)NCBI
Nodal
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247544,557,407 - 4,564,580 (-)NCBI


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system hemolymphoid system musculoskeletal system nervous system renal system reproductive system respiratory system
High
Medium
Low 1 1 1 4 2
Below cutoff 7 1 2 2 16 2 1

Sequence


Reference Sequences
RefSeq Acc Id: ENSSSCT00000043518   ⟹   ENSSSCP00000047832
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.1 Ensembl1473,349,965 - 73,360,618 (-)Ensembl
RefSeq Acc Id: XM_021073885   ⟹   XP_020929544
RefSeq Status:
Type: CODING
Position:
Pig AssemblyChrPosition (strand)Source
Sscrofa11.11473,350,358 - 73,357,064 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_020929544 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein CAJ26336 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: XP_020929544   ⟸   XM_021073885
- Sequence:
RefSeq Acc Id: ENSSSCP00000047832   ⟸   ENSSSCT00000043518
Protein Domains
TGF_BETA_2


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSSSCG00000039399 Ensembl, UniProtKB/TrEMBL
Ensembl Protein ENSSSCP00000047832 UniProtKB/TrEMBL
Ensembl Transcript ENSSSCT00000043518 UniProtKB/TrEMBL
Gene3D-CATH 2.10.90.10 UniProtKB/TrEMBL
InterPro Cystine-knot_cytokine UniProtKB/TrEMBL
  TGF-b_C UniProtKB/TrEMBL
  TGF-beta-rel UniProtKB/TrEMBL
  TGFb_CS UniProtKB/TrEMBL
NCBI Gene NODAL ENTREZGENE
PANTHER PTHR11848 UniProtKB/TrEMBL
Pfam TGF_beta UniProtKB/TrEMBL
PROSITE TGF_BETA_1 UniProtKB/TrEMBL
  TGF_BETA_2 UniProtKB/TrEMBL
SMART TGFB UniProtKB/TrEMBL
Superfamily-SCOP SSF57501 UniProtKB/TrEMBL
UniProt A0A287AVE0_PIG UniProtKB/TrEMBL
  Q0W959_PIG UniProtKB/TrEMBL
VGNC ID VGNC:90811 ENTREZGENE