Nodal (nodal) - Rat Genome Database
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Gene: Nodal (nodal) Mus musculus
Analyze
Symbol: Nodal
Name: nodal
RGD ID: 1314355
MGI Page MGI
Description: Is expressed in several structures, including compacted morula; egg cylinder; embryo mesoderm; inner cell mass; and primitive streak. Human ortholog(s) of this gene implicated in visceral heterotaxy. Orthologous to human NODAL (nodal growth differentiation factor).
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: early embryo mesoderm formation; Tg.413d; transgenic lethal 413.d
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391061,253,751 - 61,261,117 (+)NCBIGRCm39mm39
GRCm39 Ensembl1061,253,751 - 61,261,117 (+)Ensembl
GRCm381061,417,972 - 61,425,338 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1061,417,972 - 61,425,338 (+)EnsemblGRCm38mm10GRCm38
MGSCv371060,880,720 - 60,888,085 (+)NCBIGRCm37mm9NCBIm37
MGSCv361060,813,657 - 60,819,993 (+)NCBImm8
Celera1062,519,279 - 62,526,659 (+)NCBICelera
Cytogenetic Map10B4NCBI
cM Map1032.21NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
anatomical structure formation involved in morphogenesis  (IMP)
anterior/posterior axis specification  (IMP)
anterior/posterior pattern specification  (IGI,IMP)
axial mesodermal cell fate specification  (IMP)
BMP signaling pathway  (IBA)
brain development  (IMP)
cell fate commitment  (IMP)
cell migration  (IMP)
cell migration involved in gastrulation  (IDA)
determination of left/right symmetry  (IDA,IGI,IMP,TAS)
digestive system development  (IMP)
digestive tract morphogenesis  (IMP)
embryonic cranial skeleton morphogenesis  (IMP)
embryonic heart tube development  (IMP)
embryonic pattern specification  (IMP)
embryonic placenta development  (IMP)
embryonic process involved in female pregnancy  (IMP)
endoderm development  (IMP)
endodermal cell differentiation  (ISO)
epiblast cell-extraembryonic ectoderm cell signaling involved in anterior/posterior axis specification  (IMP)
floor plate morphogenesis  (IMP)
formation of anatomical boundary  (IMP)
gastrulation  (IMP)
gastrulation with mouth forming second  (IMP)
heart development  (IMP)
heart looping  (IGI)
in utero embryonic development  (IMP)
inhibition of neuroepithelial cell differentiation  (IMP)
left lung morphogenesis  (IMP)
liver development  (IMP)
lung development  (IMP)
maternal placenta development  (IMP)
maternal process involved in parturition  (IMP)
mesendoderm development  (IMP,ISO)
mesoderm formation  (IMP,TAS)
multicellular organism development  (IEA)
negative regulation of androgen receptor signaling pathway  (ISO)
negative regulation of cell development  (IMP)
negative regulation of cell differentiation  (IDA)
negative regulation of chorionic trophoblast cell proliferation  (ISO)
negative regulation of transcription by RNA polymerase II  (IDA)
negative regulation of trophoblast cell migration  (ISO)
nervous system development  (IMP)
neural fold formation  (IMP)
nodal signaling pathway  (IMP)
nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry  (IMP)
placenta development  (ISO)
polarity specification of proximal/distal axis  (IMP)
positive regulation of activin receptor signaling pathway  (ISO)
positive regulation of angiogenesis  (IMP,ISO)
positive regulation of cell population proliferation  (IMP)
positive regulation of cell-cell adhesion  (ISO)
positive regulation of cysteine-type endopeptidase activity involved in apoptotic process  (ISO)
positive regulation of DNA-binding transcription factor activity  (ISO)
positive regulation of epithelial cell proliferation  (ISO)
positive regulation of ERK1 and ERK2 cascade  (ISO)
positive regulation of pathway-restricted SMAD protein phosphorylation  (IBA,ISO)
positive regulation of SMAD protein signal transduction  (ISO)
positive regulation of transcription by RNA polymerase II  (IDA,IGI)
positive regulation of vascular endothelial growth factor production  (ISO)
primitive streak formation  (IGI)
regulation of gastrulation  (IGI)
regulation of signal transduction  (IDA)
SMAD protein signal transduction  (IBA,IDA)
stem cell population maintenance  (IGI,IMP)
tissue morphogenesis  (IMP)
transforming growth factor beta receptor signaling pathway  (ISA)
transforming growth factor beta receptor signaling pathway involved in primitive streak formation  (IMP)
trophectodermal cell differentiation  (IDA)
trophectodermal cellular morphogenesis  (IMP)
vasculature development  (IMP)

Cellular Component
extracellular region  (IDA,TAS)
extracellular space  (IBA,ISO,TAS)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal amniotic cavity morphology  (IAGP)
abnormal anterior definitive endoderm morphology  (IAGP)
abnormal anterior visceral endoderm cell migration  (IAGP)
abnormal anterior visceral endoderm morphology  (IAGP)
abnormal brain development  (IAGP)
abnormal cardiac outflow tract development  (IAGP)
abnormal craniofacial development  (IAGP)
abnormal craniofacial morphology  (IAGP)
abnormal developmental patterning  (IAGP)
abnormal diencephalon morphology  (IAGP)
abnormal digestive system development  (IAGP)
abnormal direction of embryo turning  (IAGP)
abnormal direction of heart looping  (IAGP)
abnormal distal visceral endoderm morphology  (IAGP)
abnormal ectoderm development  (IAGP)
abnormal embryo development  (IAGP)
abnormal embryo turning  (IAGP)
abnormal embryonic neuroepithelium morphology  (IAGP)
abnormal embryonic tissue morphology  (IAGP)
abnormal embryonic-extraembryonic boundary morphology  (IAGP)
abnormal extraembryonic ectoderm morphology  (IAGP)
abnormal extraembryonic mesoderm development  (IAGP)
abnormal extraembryonic tissue morphology  (IAGP)
abnormal eye development  (IAGP)
abnormal first pharyngeal arch morphology  (IAGP)
abnormal forebrain development  (IAGP)
abnormal forebrain morphology  (IAGP)
abnormal foregut morphology  (IAGP)
abnormal gastrulation  (IAGP)
abnormal gastrulation movements  (IAGP)
abnormal germ layer development  (IAGP)
abnormal head development  (IAGP)
abnormal head morphology  (IAGP)
abnormal heart apex morphology  (IAGP)
abnormal heart development  (IAGP)
abnormal heart looping  (IAGP)
abnormal heart position or orientation  (IAGP)
abnormal hindgut morphology  (IAGP)
abnormal interventricular septum morphology  (IAGP)
abnormal lateral plate mesoderm morphology  (IAGP)
abnormal left-right axis patterning  (IAGP)
abnormal liver morphology  (IAGP)
abnormal male germ cell morphology  (IAGP)
abnormal mesendoderm development  (IAGP)
abnormal mesoderm development  (IAGP)
abnormal nasal septum morphology  (IAGP)
abnormal neural fold formation  (IAGP)
abnormal neural plate morphology  (IAGP)
abnormal notochord morphology  (IAGP)
abnormal olfactory epithelium morphology  (IAGP)
abnormal parietal yolk sac morphology  (IAGP)
abnormal prechordal plate morphology  (IAGP)
abnormal primitive node morphology  (IAGP)
abnormal primitive streak formation  (IAGP)
abnormal primitive streak morphology  (IAGP)
abnormal proximal-distal axis patterning  (IAGP)
abnormal rostral-caudal axis patterning  (IAGP)
abnormal rostral-caudal patterning of the somites  (IAGP)
abnormal spleen morphology  (IAGP)
abnormal spongiotrophoblast layer morphology  (IAGP)
abnormal stomach position or orientation  (IAGP)
abnormal third ventricle morphology  (IAGP)
abnormal visceral endoderm morphology  (IAGP)
abnormal visceral yolk sac morphology  (IAGP)
absent allantois  (IAGP)
absent amnion  (IAGP)
absent amniotic folds  (IAGP)
absent floor plate  (IAGP)
absent forebrain  (IAGP)
absent foregut  (IAGP)
absent head fold  (IAGP)
absent heart tube  (IAGP)
absent mandible  (IAGP)
absent mesoderm  (IAGP)
absent midbrain  (IAGP)
absent notochord  (IAGP)
absent placental labyrinth  (IAGP)
absent prechordal plate  (IAGP)
absent primitive node  (IAGP)
absent somites  (IAGP)
absent spleen  (IAGP)
absent tongue  (IAGP)
absent visceral yolk sac  (IAGP)
aortic hypertrophy  (IAGP)
atrial septal defect  (IAGP)
cleft upper lip  (IAGP)
common atrium  (IAGP)
corneal vascularization  (IEA)
cyclopia  (IAGP)
decreased body size  (IAGP)
decreased embryo size  (IAGP)
decreased embryonic neuroepithelial cell proliferation  (IAGP)
decreased forebrain size  (IAGP)
delayed embryo turning  (IAGP)
delayed heart development  (IAGP)
dextrocardia  (IAGP)
disorganized embryonic tissue  (IAGP)
embryonic growth arrest  (IAGP)
embryonic growth retardation  (IAGP)
embryonic lethality between implantation and somite formation, complete penetrance  (IAGP)
embryonic lethality between somite formation and embryo turning, complete penetrance  (IAGP)
embryonic lethality during organogenesis, incomplete penetrance  (IAGP)
embryonic lethality prior to tooth bud stage  (IEA)
embryonic lethality, complete penetrance  (IAGP)
embryonic lethality, incomplete penetrance  (IAGP)
embryonic-extraembryonic boundary constriction  (IAGP)
enlarged floor plate  (IAGP)
enlarged pericardium  (IAGP)
expanded anterior visceral endoderm  (IAGP)
failure of primitive streak formation  (IAGP)
fused first pharyngeal arch  (IAGP)
fused somites  (IAGP)
heterotaxia  (IAGP)
holoprosencephaly  (IAGP)
increased circulating cholesterol level  (IEA)
increased circulating HDL cholesterol level  (IEA)
increased grip strength  (IEA)
increased somite number  (IAGP)
increased spongiotrophoblast size  (IAGP)
increased trophoblast giant cell number  (IAGP)
nasal septum hypoplasia  (IAGP)
neonatal lethality, complete penetrance  (IAGP)
no abnormal phenotype detected  (IAGP)
pale liver  (IAGP)
pericardial edema  (IAGP)
perinatal lethality, complete penetrance  (IAGP)
premature death  (IAGP)
prenatal lethality  (IAGP)
prenatal lethality, complete penetrance  (IAGP)
prenatal lethality, incomplete penetrance  (IAGP)
preweaning lethality, complete penetrance  (IEA)
proboscis  (IAGP)
right atrial isomerism  (IAGP)
right pulmonary isomerism  (IAGP)
right-sided isomerism  (IAGP)
rostral body truncation  (IAGP)
rostral-caudal axis duplication  (IAGP)
situs ambiguus  (IAGP)
small ectoplacental cone  (IAGP)
small liver  (IAGP)
small spleen  (IAGP)
spleen hypoplasia  (IAGP)
thin myocardium compact layer  (IAGP)
thin placenta labyrinth  (IAGP)
trabecula carnea hypoplasia  (IAGP)
transposition of great arteries  (IAGP)
truncated foregut  (IAGP)
truncated notochord  (IAGP)
References

Additional References at PubMed
PMID:1363228   PMID:1467556   PMID:1879365   PMID:3762693   PMID:7700351   PMID:7768172   PMID:7924997   PMID:8429908   PMID:8582278   PMID:8610012   PMID:8610013   PMID:9049629  
PMID:9056778   PMID:9354794   PMID:9376323   PMID:9420335   PMID:9466889   PMID:9533949   PMID:9598342   PMID:9655392   PMID:9799237   PMID:9825674   PMID:9851841   PMID:9988215  
PMID:10349636   PMID:10385121   PMID:10385626   PMID:10385627   PMID:10411502   PMID:10431240   PMID:10452853   PMID:10477299   PMID:10500184   PMID:10512203   PMID:10518210   PMID:10521397  
PMID:10545241   PMID:10574770   PMID:10642791   PMID:10667782   PMID:10677256   PMID:10678167   PMID:10700179   PMID:10748463   PMID:10804177   PMID:10809672   PMID:10887078   PMID:10964471  
PMID:11020711   PMID:11042159   PMID:11076861   PMID:11134352   PMID:11171400   PMID:11217851   PMID:11245568   PMID:11311163   PMID:11358868   PMID:11358869   PMID:11418863   PMID:11440720  
PMID:11456449   PMID:11471154   PMID:11517919   PMID:11703930   PMID:11832378   PMID:11836504   PMID:11900971   PMID:11909953   PMID:11927540   PMID:11959836   PMID:12052855   PMID:12062060  
PMID:12091315   PMID:12112458   PMID:12117810   PMID:12231623   PMID:12361961   PMID:12372301   PMID:12381664   PMID:12431380   PMID:12441287   PMID:12447384   PMID:12466851   PMID:12471260  
PMID:12477932   PMID:12520002   PMID:12642485   PMID:12645927   PMID:12654299   PMID:12666204   PMID:12730123   PMID:12730124   PMID:12842913   PMID:12904583   PMID:14505572   PMID:14511481  
PMID:14566055   PMID:14603322   PMID:14607953   PMID:14610273   PMID:14623818   PMID:14633973   PMID:14657239   PMID:14745963   PMID:14761651   PMID:15004567   PMID:15062104   PMID:15121860  
PMID:15132998   PMID:15142971   PMID:15215210   PMID:15302604   PMID:15342483   PMID:15371312   PMID:15454269   PMID:15466485   PMID:15475956   PMID:15485907   PMID:15504371   PMID:15505202  
PMID:15525667   PMID:15533813   PMID:15731404   PMID:15736223   PMID:15750185   PMID:15829518   PMID:15840001   PMID:15870281   PMID:15910242   PMID:16061793   PMID:16109169   PMID:16141072  
PMID:16141073   PMID:16155214   PMID:16256739   PMID:16291790   PMID:16311594   PMID:16316413   PMID:16368929   PMID:16481355   PMID:16496285   PMID:16556918   PMID:16564040   PMID:16580991  
PMID:16672339   PMID:16678814   PMID:16728477   PMID:16765933   PMID:16790473   PMID:16801545   PMID:16887818   PMID:16943282   PMID:16950123   PMID:17027958   PMID:17075876   PMID:17075880  
PMID:17182901   PMID:17210915   PMID:17316383   PMID:17341133   PMID:17389379   PMID:17507393   PMID:17507406   PMID:17535850   PMID:17568773   PMID:17697936   PMID:17699604   PMID:17884984  
PMID:17913787   PMID:17936261   PMID:18061569   PMID:18079174   PMID:18089557   PMID:18171685   PMID:18177426   PMID:18241853   PMID:18268105   PMID:18287559   PMID:18393305   PMID:18406693  
PMID:18550712   PMID:18575602   PMID:18697220   PMID:18697221   PMID:18701545   PMID:18772886   PMID:18773491   PMID:18781635   PMID:18794329   PMID:18799693   PMID:18823971   PMID:18929642  
PMID:18930042   PMID:18945958   PMID:18974875   PMID:18981480   PMID:19001664   PMID:19004860   PMID:19013461   PMID:19056886   PMID:19153222   PMID:19161597   PMID:19174539   PMID:19605690  
PMID:19666828   PMID:19688838   PMID:19716815   PMID:19877283   PMID:19879143   PMID:19906859   PMID:20040491   PMID:20153842   PMID:20178780   PMID:20427282   PMID:20487527   PMID:20508035  
PMID:20562861   PMID:20571128   PMID:20573697   PMID:20637190   PMID:20643351   PMID:20665854   PMID:20678497   PMID:20689803   PMID:20704721   PMID:20708584   PMID:20730911   PMID:20826531  
PMID:20876279   PMID:20876643   PMID:21047506   PMID:21069829   PMID:21089073   PMID:21116837   PMID:21203428   PMID:21209331   PMID:21224256   PMID:21267068   PMID:21270430   PMID:21307093  
PMID:21364967   PMID:21419113   PMID:21445260   PMID:21466802   PMID:21660050   PMID:21677750   PMID:21693517   PMID:21725307   PMID:21731500   PMID:21731673   PMID:21750036   PMID:21784065  
PMID:21831921   PMID:21862554   PMID:21873635   PMID:21896659   PMID:21953618   PMID:22056140   PMID:22202776   PMID:22233545   PMID:22346733   PMID:22357932   PMID:22378764   PMID:22383895  
PMID:22396454   PMID:22412348   PMID:22550067   PMID:22554696   PMID:22560297   PMID:22627279   PMID:22669107   PMID:22682244   PMID:22698281   PMID:22872153   PMID:22912414   PMID:22983710  
PMID:22990867   PMID:23034635   PMID:23081664   PMID:23213411   PMID:23213481   PMID:23221368   PMID:23271656   PMID:23274954   PMID:23342175   PMID:23348697   PMID:23473982   PMID:23544137  
PMID:23552073   PMID:23651855   PMID:23707899   PMID:23742838   PMID:24114072   PMID:24318811   PMID:24558432   PMID:24576537   PMID:24585447   PMID:24697898   PMID:24704359   PMID:24704361  
PMID:24780629   PMID:24798330   PMID:24801048   PMID:24859004   PMID:24952961   PMID:24960041   PMID:25142465   PMID:25219788   PMID:25344072   PMID:25480920   PMID:25511461   PMID:25528267  
PMID:25536399   PMID:25775035   PMID:25813538   PMID:25869585   PMID:25904100   PMID:26494787   PMID:26496195   PMID:26534985   PMID:26791244   PMID:26801181   PMID:26975355   PMID:27072135  
PMID:27217206   PMID:27272319   PMID:27305836   PMID:27353389   PMID:27466203   PMID:27521049   PMID:27760115   PMID:27881714   PMID:27889317   PMID:27924807   PMID:27930333   PMID:28182636  
PMID:28188179   PMID:28191871   PMID:28619992   PMID:28669603   PMID:28839193   PMID:29138408   PMID:29140251   PMID:29168693   PMID:29206913   PMID:29992973   PMID:30026265   PMID:30256721  
PMID:30409165   PMID:30446628   PMID:30842446   PMID:31204172   PMID:31240264   PMID:31308417   PMID:31391582   PMID:31887266   PMID:32439762   PMID:32521258   PMID:32523119   PMID:32546759  
PMID:33171097  


Genomics

Comparative Map Data
Nodal
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391061,253,751 - 61,261,117 (+)NCBIGRCm39mm39
GRCm39 Ensembl1061,253,751 - 61,261,117 (+)Ensembl
GRCm381061,417,972 - 61,425,338 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1061,417,972 - 61,425,338 (+)EnsemblGRCm38mm10GRCm38
MGSCv371060,880,720 - 60,888,085 (+)NCBIGRCm37mm9NCBIm37
MGSCv361060,813,657 - 60,819,993 (+)NCBImm8
Celera1062,519,279 - 62,526,659 (+)NCBICelera
Cytogenetic Map10B4NCBI
cM Map1032.21NCBI
NODAL
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1070,431,936 - 70,447,951 (-)EnsemblGRCh38hg38GRCh38
GRCh381070,431,936 - 70,447,951 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371072,191,692 - 72,207,707 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361071,862,077 - 71,871,429 (-)NCBINCBI36hg18NCBI36
Build 341071,862,076 - 71,871,429NCBI
Celera1065,472,123 - 65,481,898 (-)NCBI
Cytogenetic Map10q22.1NCBI
HuRef1066,185,532 - 66,195,306 (-)NCBIHuRef
CHM1_11072,473,912 - 72,483,685 (-)NCBICHM1_1
Nodal
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.22029,368,436 - 29,376,837 (+)NCBI
Rnor_6.0 Ensembl2031,035,729 - 31,044,096 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.02031,035,729 - 31,044,096 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.02032,822,880 - 32,831,247 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42029,546,982 - 29,555,419 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.12029,560,988 - 29,568,536 (+)NCBI
Celera2030,797,163 - 30,805,518 (+)NCBICelera
Cytogenetic Map20q11NCBI
Nodal
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543720,828,448 - 20,835,628 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495543720,828,448 - 20,835,486 (+)NCBIChiLan1.0ChiLan1.0
NODAL
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11069,433,959 - 69,443,972 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1069,433,959 - 69,443,972 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01066,906,866 - 66,916,938 (-)NCBIMhudiblu_PPA_v0panPan3
NODAL
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl421,367,583 - 21,375,151 (-)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.1421,366,828 - 21,374,623 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Nodal
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_0049365218,171,146 - 8,178,802 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NODAL
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1473,349,965 - 73,360,618 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11473,350,358 - 73,357,064 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
NODAL
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1960,852,567 - 60,863,225 (+)NCBI
ChlSab1.1 Ensembl960,853,763 - 60,862,839 (+)Ensembl
Nodal
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247544,557,407 - 4,564,580 (-)NCBI

Position Markers
BB283668  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381061,425,142 - 61,425,229UniSTSGRCm38
MGSCv371060,887,890 - 60,887,977UniSTSGRCm37
Celera1062,526,464 - 62,526,551UniSTS
Cytogenetic Map10B4UniSTS
cM Map1031.5UniSTS
Whitehead/MRC_RH10693.05UniSTS
Nodal  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381061,423,566 - 61,424,561UniSTSGRCm38
MGSCv371060,887,453 - 60,887,552UniSTSGRCm37
MGSCv371060,886,386 - 60,887,366UniSTSGRCm37
Celera1062,524,871 - 62,525,883UniSTS
Cytogenetic Map10B4UniSTS
cM Map1031.5UniSTS
cM Map1031.5UniSTS
D10Mit112.1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381061,424,705 - 61,424,899UniSTSGRCm38
MGSCv371060,887,453 - 60,887,647UniSTSGRCm37
Celera1062,526,027 - 62,526,221UniSTS
Cytogenetic Map10B4UniSTS
cM Map1031.5UniSTS
cM Map10 UniSTS
Whitehead Genetic1023.0UniSTS
D10Mit112  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381061,424,897 - 61,425,027UniSTSGRCm38
MGSCv371060,887,645 - 60,887,775UniSTSGRCm37
Celera1062,526,219 - 62,526,349UniSTS
Cytogenetic Map10B4UniSTS
cM Map1031.5UniSTS
Whitehead Genetic1023.0UniSTS
D10Mit112.2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381061,425,078 - 61,425,193UniSTSGRCm38
MGSCv371060,887,826 - 60,887,941UniSTSGRCm37
Celera1062,526,400 - 62,526,515UniSTS
Cytogenetic Map10B4UniSTS
cM Map1031.5UniSTS
cM Map10 UniSTS
Whitehead Genetic1023.0UniSTS
GDB:533003  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381061,421,412 - 61,421,464UniSTSGRCm38
GRCm38523,364,604 - 23,364,748UniSTSGRCm38
MGSCv37522,870,422 - 22,870,566UniSTSGRCm37
MGSCv371060,884,160 - 60,884,212UniSTSGRCm37
Celera1062,522,719 - 62,522,771UniSTS
Cytogenetic Map10B4UniSTS
Cytogenetic Map5A3UniSTS
cM Map1031.5UniSTS
Nodal  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381061,423,638 - 61,424,618UniSTSGRCm38
MGSCv371060,886,386 - 60,887,366UniSTSGRCm37
Celera1062,524,943 - 62,525,940UniSTS
Cytogenetic Map10B4UniSTS
cM Map1031.5UniSTS
Nodal  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map10B4UniSTS
Nodal  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381061,424,705 - 61,424,804UniSTSGRCm38
MGSCv371060,887,453 - 60,887,552UniSTSGRCm37
Celera1062,526,027 - 62,526,126UniSTS
Cytogenetic Map10B4UniSTS


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1357740Obsty3_mobesity 3 (mouse)Not determined108359714116355075Mouse
1301386Sysbp1_msystolic blood pressure 1 (mouse)Not determined101023252187565233Mouse
1357825Kidpq2_mkidney weight percentage QTL 2 (mouse)Not determined101282830784243920Mouse
1357656Hrtq3_mheart weight QTL 3 (mouse)Not determined101282830784243920Mouse
1357864Scfpq1_msubcutaneous fat pad percentage QTL 1 (mouse)Not determined101282830784243920Mouse
1357893Lvrq4_mliver weight QTL 4 (mouse)Not determined101282830784243920Mouse
4142380W3q11_mweight 3 weeks QTL 11 (mouse)Not determined1282830784243920Mouse
4141943W6q6_mweight 6 weeks QTL 6 (mouse)Not determined1282830784243920Mouse
4141956Egq7_mearly growth QTL 7 (mouse)Not determined1282830784243920Mouse
4142272W10q5_mweight 10 weeks QTL 5 (mouse)Not determined1282830784243920Mouse
39128215Lwq17_mliver weight QTL 17 (mouse)101282830784243920Mouse
1302067Scc9_mcolon tumor susceptibility 9 (mouse)Not determined1018383585125739363Mouse
27226772Tibl13_mtibia length 13, 10 week (mouse)1019000000129800000Mouse
1558757Eae34_mexperimental allergic encephalomyelitis susceptibility 34 (mouse)Not determined1021532255114381325Mouse
1301003Lmblgq4_mlimb length QTL 4 (mouse)Not determined102171529368255809Mouse
26884403Cvht8_mcranial vault height 8, 16 week (mouse)102300000091200000Mouse
26884426Cvht1_mcranial vault height 1, 5 week (mouse)1024800000121200000Mouse
1300898Cfid_mcystic fibrosis intestinal distress (mouse)Not determined102984430763844387Mouse
10045632Heal16_mwound healing/regeneration 16 (mouse)Not determined103109840365098534Mouse
1357558Bmch4_mbone mechanical trait 4 (mouse)Not determined103170104065701188Mouse
27095920Pglq9_mpelvic girdle length QTL 9, 10 week (mouse)103390000071000000Mouse
27095911Pglq15_mpelvic girdle length QTL 15, 16 week (mouse)1039300000129800000Mouse
27226764Tibl19_mtibia length 19, 16 week (mouse)1039300000129800000Mouse
4141070Ltgq1_mliver triglyceride QTL 1 (mouse)Not determined4140150475401504Mouse
26884411Bzwq8_mbi-zygomatic width QTL 8, 10 week (mouse)1045000000116100000Mouse
26884407Bzwq14_mbi-zygomatic width QTL 14, 16 wee (mouse)1045600000120800000Mouse
26884421Cvht5_mcranial vault height 5, 10 week (mouse)104570000069300000Mouse
26884400Huml5_mhumerus length 5, 16 week (mouse)104640000069400000Mouse
4142313Angvq1_mangiogenesis by VEGF QTL 1 (mouse)Not determined4684430782655287Mouse
4141159Phl2_mprogressive hearing loss 2 (mouse)Not determined104809840370276821Mouse
1302150Bbaa18_mB.burgdorferi-associated arthritis 18 (mouse)Not determined104950223383502378Mouse
4142169Pbwg16_mpostnatal body weight growth 16 (mouse)Not determined105001240884012633Mouse
1300597Skull14_mskull morphology 14 (mouse)Not determined105001240884012633Mouse
10045641Jckm3_mjuvenile cystic kidney modifier 3 (mouse)Not determined105001240884012633Mouse
1301966Lifespan2_mlife span 2 (mouse)Not determined105001244384012618Mouse
1357737Hpcr2_mhepatocarcinogen resistance 2 (mouse)Not determined105001244384012618Mouse
1300882Ath17_matherosclerosis 17 (mouse)Not determined105125566085255809Mouse
1301502Eae17_msusceptibility to experimental allergic encephalomyelitis 17 (mouse)Not determined105125566085255809Mouse
1301380Cia8_mcollagen induced arthritis QTL 8 (mouse)Not determined105161730482655287Mouse
14746991Manh68_mmandible shape 68 (mouse)105244466786444667Mouse
1301787Bsc1_mbrain size control 1 (mouse)Not determined105868113592681262Mouse
26884450Sklq15_mskull length QTL 15, 16 week (mouse)1059500000122500000Mouse
13208560Wght9_mweight 9 (mouse)1060000000121000000Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:283
Count of miRNA genes:220
Interacting mature miRNAs:244
Transcripts:ENSMUST00000049339
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000049339   ⟹   ENSMUSP00000039653
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl1061,417,972 - 61,425,338 (+)Ensembl
RefSeq Acc Id: NM_013611   ⟹   NP_038639
RefSeq Status: REVIEWED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391061,253,751 - 61,261,117 (+)NCBI
GRCm381061,417,972 - 61,425,338 (+)NCBI
MGSCv371060,880,720 - 60,888,085 (+)RGD
Celera1062,519,279 - 62,526,659 (+)RGD
cM Map10 ENTREZGENE
Sequence:
Reference Sequences
RefSeq Acc Id: NP_038639   ⟸   NM_013611
- Peptide Label: preproprotein
- UniProtKB: P43021 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSMUSP00000039653   ⟸   ENSMUST00000049339
Protein Domains
TGF_BETA_2

Promoters
RGD ID:6819671
Promoter ID:MM_KWN:4265
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:ES_Cell
Transcripts:OTTMUST00000050919
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361060,880,371 - 60,881,172 (+)MPROMDB
RGD ID:8672092
Promoter ID:EPDNEW_M14077
Type:single initiation site
Name:Nodal_1
Description:Mus musculus nodal , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381061,418,288 - 61,418,348EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:97359 AgrOrtholog
Ensembl Genes ENSMUSG00000037171 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSMUSP00000039653 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000049339 ENTREZGENE, UniProtKB/Swiss-Prot
Gene3D-CATH 2.10.90.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Cystine-knot_cytokine UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TGF-b_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TGF-beta-rel UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TGFb_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:18119 UniProtKB/Swiss-Prot
MGD MGI:97359 ENTREZGENE
NCBI Gene 18119 ENTREZGENE
PANTHER PTHR11848 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam TGF_beta UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Nodal PhenoGen
PROSITE TGF_BETA_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TGF_BETA_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART TGFB UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF57501 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0PK81_MOUSE UniProtKB/TrEMBL
  NODAL_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary Q8BH87 UniProtKB/Swiss-Prot