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Gene: Nodal (nodal) Mus musculus
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Symbol: Nodal
Name: nodal
Description: This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate the mature protein, which regulates early embryonic development. Homozygous knockout mice for this gene exhibit early embryonic lethality, while expression of a hypomorphic allele results in defects in anteroposterior and left-right patterning. [provided by RefSeq, Aug 2016]
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: early embryo mesoderm formation; Tg.413d; transgenic lethal 413.d
Orthologs:
Homo sapiens (human) : NODAL (nodal growth differentiation factor)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Nodal (nodal growth differentiation factor)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Nodal (nodal growth differentiation factor)
Pan paniscus (bonobo/pygmy chimpanzee) : NODAL (nodal growth differentiation factor)
Canis lupus familiaris (dog) : NODAL (nodal growth differentiation factor)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Nodal (nodal growth differentiation factor)
Sus scrofa (pig) : NODAL (nodal growth differentiation factor)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm381061,417,972 - 61,425,338 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv371060,880,720 - 60,888,085 (+)NCBIGRCm37mm9NCBIm37
MGSCv361060,813,657 - 60,819,993 (+)NCBImm8
Celera1062,519,279 - 62,526,659 (+)NCBICelera
Cytogenetic Map10 B4NCBI
cM Map1032.21NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Promoters

Additional Information

External Database Links
 
More on Nodal
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1314355
Created: 2005-01-12
Species: Mus musculus
Last Modified: 2019-09-12
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.