Nodal (nodal growth differentiation factor) - Rat Genome Database

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Gene: Nodal (nodal growth differentiation factor) Mus musculus
Analyze
Symbol: Nodal
Name: nodal growth differentiation factor (Ensembl:nodal)
RGD ID: 1314355
MGI Page MGI
Description: Enables receptor ligand activity. Involved in several processes, including determination of left/right asymmetry in lateral mesoderm; nodal signaling pathway; and positive regulation of angiogenesis. Acts upstream of or within several processes, including axis specification; embryonic morphogenesis; and regulation of embryonic development. Located in extracellular region. Is expressed in several structures, including ectoderm; egg cylinder; embryo mesoderm; gonad; and primitive streak. Human ortholog(s) of this gene implicated in visceral heterotaxy. Orthologous to human NODAL (nodal growth differentiation factor).
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: early embryo mesoderm formation; Tg.413d; transgenic lethal 413.d
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391061,253,751 - 61,261,117 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1061,253,751 - 61,261,117 (+)EnsemblGRCm39 Ensembl
GRCm381061,417,972 - 61,425,338 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1061,417,972 - 61,425,338 (+)EnsemblGRCm38mm10GRCm38
MGSCv371060,880,720 - 60,888,085 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361060,813,657 - 60,819,993 (+)NCBIMGSCv36mm8
Celera1062,519,279 - 62,526,659 (+)NCBICelera
Cytogenetic Map10B4NCBI
cM Map1032.21NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
anatomical structure formation involved in morphogenesis  (IMP)
anterior/posterior axis specification  (IMP)
anterior/posterior pattern specification  (IGI,IMP)
axial mesodermal cell fate specification  (IMP)
brain development  (IMP)
cell differentiation  (IDA)
cell fate commitment  (IMP)
cell migration  (IMP)
cell migration involved in gastrulation  (IDA)
cell population proliferation  (IMP)
determination of left/right asymmetry in lateral mesoderm  (IMP)
determination of left/right symmetry  (IDA,IGI,IMP,TAS)
digestive system development  (IMP)
digestive tract morphogenesis  (IMP)
embryonic cranial skeleton morphogenesis  (IMP)
embryonic heart tube development  (IMP)
embryonic pattern specification  (IMP)
embryonic placenta development  (IMP)
embryonic process involved in female pregnancy  (IMP)
endoderm development  (IMP)
endodermal cell differentiation  (ISO)
epiblast cell-extraembryonic ectoderm cell signaling involved in anterior/posterior axis specification  (IMP)
female pregnancy  (ISO)
floor plate morphogenesis  (IMP)
formation of anatomical boundary  (IMP)
gastrulation  (IMP)
gastrulation with mouth forming second  (IMP)
germ cell development  (IMP)
heart development  (IMP)
heart looping  (IGI)
in utero embryonic development  (IMP)
inhibition of neuroepithelial cell differentiation  (IMP)
left lung morphogenesis  (IMP)
liver development  (IMP)
lung development  (IMP)
maternal placenta development  (IMP)
maternal process involved in parturition  (IMP)
mesendoderm development  (IMP,ISO)
mesoderm formation  (IMP,TAS)
negative regulation of androgen receptor signaling pathway  (ISO)
negative regulation of cell development  (IMP)
negative regulation of cell differentiation  (IDA)
negative regulation of chorionic trophoblast cell proliferation  (ISO)
negative regulation of reproductive process  (IMP)
negative regulation of transcription by RNA polymerase II  (IDA)
negative regulation of trophoblast cell migration  (ISO)
nervous system development  (IMP)
neural fold formation  (IMP)
nodal signaling pathway  (IMP)
placenta development  (ISO)
polarity specification of proximal/distal axis  (IMP)
positive regulation of activin receptor signaling pathway  (ISO)
positive regulation of angiogenesis  (IMP,ISO)
positive regulation of cell population proliferation  (IMP)
positive regulation of cell-cell adhesion  (ISO)
positive regulation of epithelial cell proliferation  (ISO)
positive regulation of ERK1 and ERK2 cascade  (ISO)
positive regulation of SMAD protein signal transduction  (ISO)
positive regulation of transcription by RNA polymerase II  (IDA,IGI)
positive regulation of vascular endothelial growth factor production  (ISO)
primitive streak formation  (IGI)
regulation of gastrulation  (IGI)
regulation of signal transduction  (IDA)
somatic stem cell population maintenance  (IGI,IMP)
stem cell population maintenance  (IGI)
tissue morphogenesis  (IMP)
transforming growth factor beta receptor signaling pathway  (IMP,ISA)
trophectodermal cell differentiation  (IDA)
trophectodermal cellular morphogenesis  (IMP)
vasculature development  (IMP)

Cellular Component
extracellular region  (IDA,TAS)
extracellular space  (IBA,ISO,TAS)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal amniotic cavity morphology  (IAGP)
abnormal anterior definitive endoderm morphology  (IAGP)
abnormal anterior visceral endoderm cell migration  (IAGP)
abnormal anterior visceral endoderm morphology  (IAGP)
abnormal brain development  (IAGP)
abnormal cardiac outflow tract development  (IAGP)
abnormal craniofacial development  (IAGP)
abnormal craniofacial morphology  (IAGP)
abnormal developmental patterning  (IAGP)
abnormal diencephalon morphology  (IAGP)
abnormal digestive system development  (IAGP)
abnormal direction of embryo turning  (IAGP)
abnormal direction of heart looping  (IAGP)
abnormal distal visceral endoderm morphology  (IAGP)
abnormal ectoderm development  (IAGP)
abnormal embryo development  (IAGP)
abnormal embryo turning  (IAGP)
abnormal embryonic neuroepithelium morphology  (IAGP)
abnormal embryonic tissue morphology  (IAGP)
abnormal embryonic-extraembryonic boundary morphology  (IAGP)
abnormal extraembryonic ectoderm morphology  (IAGP)
abnormal extraembryonic mesoderm development  (IAGP)
abnormal extraembryonic tissue morphology  (IAGP)
abnormal eye development  (IAGP)
abnormal first pharyngeal arch morphology  (IAGP)
abnormal forebrain development  (IAGP)
abnormal forebrain morphology  (IAGP)
abnormal foregut morphology  (IAGP)
abnormal gastrulation  (IAGP)
abnormal gastrulation movements  (IAGP)
abnormal germ layer development  (IAGP)
abnormal head development  (IAGP)
abnormal head morphology  (IAGP)
abnormal heart apex morphology  (IAGP)
abnormal heart development  (IAGP)
abnormal heart looping  (IAGP)
abnormal heart position or orientation  (IAGP)
abnormal hindgut morphology  (IAGP)
abnormal interventricular septum morphology  (IAGP)
abnormal lateral plate mesoderm morphology  (IAGP)
abnormal left-right axis patterning  (IAGP)
abnormal liver morphology  (IAGP)
abnormal male germ cell morphology  (IAGP)
abnormal mesendoderm development  (IAGP)
abnormal mesoderm development  (IAGP)
abnormal nasal septum morphology  (IAGP)
abnormal neural fold formation  (IAGP)
abnormal neural plate morphology  (IAGP)
abnormal notochord morphology  (IAGP)
abnormal olfactory epithelium morphology  (IAGP)
abnormal parietal yolk sac morphology  (IAGP)
abnormal prechordal plate morphology  (IAGP)
abnormal primitive node morphology  (IAGP)
abnormal primitive streak formation  (IAGP)
abnormal primitive streak morphology  (IAGP)
abnormal proximal-distal axis patterning  (IAGP)
abnormal rostral-caudal axis patterning  (IAGP)
abnormal rostral-caudal patterning of the somites  (IAGP)
abnormal spleen morphology  (IAGP)
abnormal spongiotrophoblast layer morphology  (IAGP)
abnormal stomach position or orientation  (IAGP)
abnormal third ventricle morphology  (IAGP)
abnormal visceral endoderm morphology  (IAGP)
abnormal visceral yolk sac morphology  (IAGP)
absent allantois  (IAGP)
absent amnion  (IAGP)
absent amniotic folds  (IAGP)
absent floor plate  (IAGP)
absent forebrain  (IAGP)
absent foregut  (IAGP)
absent head fold  (IAGP)
absent heart tube  (IAGP)
absent mandible  (IAGP)
absent mesoderm  (IAGP)
absent midbrain  (IAGP)
absent notochord  (IAGP)
absent placental labyrinth  (IAGP)
absent prechordal plate  (IAGP)
absent primitive node  (IAGP)
absent somites  (IAGP)
absent spleen  (IAGP)
absent tongue  (IAGP)
absent visceral yolk sac  (IAGP)
aortic hypertrophy  (IAGP)
atrial septal defect  (IAGP)
cleft upper lip  (IAGP)
common atrium  (IAGP)
corneal vascularization  (IEA)
cyclopia  (IAGP)
decreased body size  (IAGP)
decreased embryo size  (IAGP)
decreased embryonic neuroepithelial cell proliferation  (IAGP)
decreased forebrain size  (IAGP)
decreased locomotor activity  (IEA)
delayed embryo turning  (IAGP)
delayed heart development  (IAGP)
dextrocardia  (IAGP)
disorganized embryonic tissue  (IAGP)
embryonic growth arrest  (IAGP)
embryonic growth retardation  (IAGP)
embryonic lethality between implantation and somite formation, complete penetrance  (IAGP)
embryonic lethality between somite formation and embryo turning, complete penetrance  (IAGP)
embryonic lethality during organogenesis, incomplete penetrance  (IAGP)
embryonic lethality prior to tooth bud stage  (IEA)
embryonic lethality, complete penetrance  (IAGP)
embryonic lethality, incomplete penetrance  (IAGP)
embryonic-extraembryonic boundary constriction  (IAGP)
enlarged floor plate  (IAGP)
enlarged pericardium  (IAGP)
expanded anterior visceral endoderm  (IAGP)
failure of primitive streak formation  (IAGP)
fused first pharyngeal arch  (IAGP)
fused somites  (IAGP)
heterotaxia  (IAGP)
holoprosencephaly  (IAGP)
increased circulating cholesterol level  (IEA)
increased circulating HDL cholesterol level  (IEA)
increased circulating triglyceride level  (IEA)
increased grip strength  (IEA)
increased large unstained cell number  (IEA)
increased somite number  (IAGP)
increased spongiotrophoblast size  (IAGP)
increased trophoblast giant cell number  (IAGP)
nasal septum hypoplasia  (IAGP)
neonatal lethality, complete penetrance  (IAGP)
no abnormal phenotype detected  (IAGP)
pale liver  (IAGP)
pericardial edema  (IAGP)
perinatal lethality, complete penetrance  (IAGP)
premature death  (IAGP)
prenatal lethality  (IAGP)
prenatal lethality, complete penetrance  (IAGP)
prenatal lethality, incomplete penetrance  (IAGP)
preweaning lethality, complete penetrance  (IEA)
proboscis  (IAGP)
right atrial isomerism  (IAGP)
right pulmonary isomerism  (IAGP)
right-sided isomerism  (IAGP)
rostral body truncation  (IAGP)
rostral-caudal axis duplication  (IAGP)
situs ambiguus  (IAGP)
small ectoplacental cone  (IAGP)
small liver  (IAGP)
small spleen  (IAGP)
spleen hypoplasia  (IAGP)
thin myocardium compact layer  (IAGP)
thin placenta labyrinth  (IAGP)
trabecula carnea hypoplasia  (IAGP)
transposition of great arteries  (IAGP)
truncated foregut  (IAGP)
truncated notochord  (IAGP)
References

References - curated
# Reference Title Reference Citation
1. The role of the brachyury gene in heart development and left-right specification in the mouse. King T, etal., Mech Dev 1998 Dec;79(1-2):29-37.
2. lefty-1 is required for left-right determination as a regulator of lefty-2 and nodal. Meno C, etal., Cell 1998 Aug 7;94(3):287-97.
3. MGDs mouse GO annotations MGD data from the GO Consortium
4. MGD IEA MGD IEA
5. Identification and functional characterization of NODAL rare variants in heterotaxy and isolated cardiovascular malformations. Mohapatra B, etal., Hum Mol Genet. 2009 Mar 1;18(5):861-71. doi: 10.1093/hmg/ddn411. Epub 2008 Dec 8.
6. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
7. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
8. Mouse MP Annotation Import Pipeline RGD automated import pipeline
9. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
10. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
11. ACVR2A promoter polymorphism rs1424954 in the Activin-A signaling pathway in trophoblasts. Thulluru HK, etal., Placenta. 2015 Apr;36(4):345-9. doi: 10.1016/j.placenta.2015.01.010. Epub 2015 Jan 26.
12. Nodal increases the malignancy of childhood neuroblastoma cells via regulation of Zeb1. Wu J, etal., Biofactors. 2019 May;45(3):355-363. doi: 10.1002/biof.1505. Epub 2019 Apr 15.
Additional References at PubMed
PMID:1363228   PMID:1467556   PMID:1879365   PMID:3762693   PMID:7700351   PMID:7768172   PMID:7924997   PMID:8429908   PMID:8582278   PMID:8610012   PMID:8610013   PMID:9049629  
PMID:9056778   PMID:9354794   PMID:9376323   PMID:9420335   PMID:9466889   PMID:9533949   PMID:9598342   PMID:9655392   PMID:9799237   PMID:9825674   PMID:9851841   PMID:9988215  
PMID:10349636   PMID:10385121   PMID:10385626   PMID:10385627   PMID:10411502   PMID:10431240   PMID:10452853   PMID:10477299   PMID:10500184   PMID:10512203   PMID:10518210   PMID:10521397  
PMID:10545241   PMID:10574770   PMID:10642791   PMID:10667782   PMID:10677256   PMID:10678167   PMID:10700179   PMID:10748463   PMID:10804177   PMID:10809672   PMID:10887078   PMID:10964471  
PMID:11020711   PMID:11042159   PMID:11076861   PMID:11134352   PMID:11171400   PMID:11217851   PMID:11245568   PMID:11311163   PMID:11358868   PMID:11358869   PMID:11418863   PMID:11440720  
PMID:11456449   PMID:11471154   PMID:11517919   PMID:11703930   PMID:11832378   PMID:11836504   PMID:11900971   PMID:11909953   PMID:11927540   PMID:11959836   PMID:12052855   PMID:12062060  
PMID:12091315   PMID:12112458   PMID:12117810   PMID:12231623   PMID:12361961   PMID:12372301   PMID:12381664   PMID:12431380   PMID:12441287   PMID:12447384   PMID:12466851   PMID:12471260  
PMID:12477932   PMID:12520002   PMID:12642485   PMID:12645927   PMID:12654299   PMID:12666204   PMID:12730123   PMID:12730124   PMID:12842913   PMID:12904583   PMID:14505572   PMID:14511481  
PMID:14566055   PMID:14603322   PMID:14607953   PMID:14610273   PMID:14623818   PMID:14633973   PMID:14657239   PMID:14745963   PMID:14761651   PMID:15004567   PMID:15062104   PMID:15121860  
PMID:15132998   PMID:15142971   PMID:15215210   PMID:15302604   PMID:15342483   PMID:15371312   PMID:15454269   PMID:15466485   PMID:15475956   PMID:15485907   PMID:15504371   PMID:15505202  
PMID:15525667   PMID:15533813   PMID:15731404   PMID:15736223   PMID:15750185   PMID:15829518   PMID:15840001   PMID:15870281   PMID:15910242   PMID:16061793   PMID:16109169   PMID:16141072  
PMID:16141073   PMID:16155214   PMID:16256739   PMID:16291790   PMID:16311594   PMID:16316413   PMID:16368929   PMID:16481355   PMID:16496285   PMID:16556918   PMID:16564040   PMID:16580991  
PMID:16672339   PMID:16678814   PMID:16728477   PMID:16765933   PMID:16790473   PMID:16801545   PMID:16887818   PMID:16943282   PMID:16950123   PMID:17027958   PMID:17075876   PMID:17075880  
PMID:17182901   PMID:17210915   PMID:17316383   PMID:17341133   PMID:17389379   PMID:17507393   PMID:17507406   PMID:17535850   PMID:17568773   PMID:17697936   PMID:17699604   PMID:17884984  
PMID:17913787   PMID:17936261   PMID:18061569   PMID:18079174   PMID:18089557   PMID:18171685   PMID:18177426   PMID:18241853   PMID:18268105   PMID:18287559   PMID:18393305   PMID:18406693  
PMID:18550712   PMID:18575602   PMID:18697220   PMID:18697221   PMID:18701545   PMID:18772886   PMID:18773491   PMID:18781635   PMID:18794329   PMID:18799693   PMID:18823971   PMID:18929642  
PMID:18930042   PMID:18945958   PMID:18974875   PMID:18981480   PMID:19001664   PMID:19004860   PMID:19013461   PMID:19056886   PMID:19153222   PMID:19161597   PMID:19174539   PMID:19605690  
PMID:19666828   PMID:19688838   PMID:19716815   PMID:19877283   PMID:19879143   PMID:19906859   PMID:20040491   PMID:20153842   PMID:20178780   PMID:20427282   PMID:20487527   PMID:20508035  
PMID:20562861   PMID:20571128   PMID:20573697   PMID:20637190   PMID:20643351   PMID:20665854   PMID:20678497   PMID:20689803   PMID:20704721   PMID:20708584   PMID:20730911   PMID:20826531  
PMID:20876279   PMID:20876643   PMID:21047506   PMID:21069829   PMID:21089073   PMID:21116837   PMID:21203428   PMID:21209331   PMID:21224256   PMID:21267068   PMID:21270430   PMID:21307093  
PMID:21364967   PMID:21419113   PMID:21445260   PMID:21466802   PMID:21660050   PMID:21677750   PMID:21693517   PMID:21725307   PMID:21731500   PMID:21731673   PMID:21750036   PMID:21784065  
PMID:21831921   PMID:21862554   PMID:21873635   PMID:21896659   PMID:21953618   PMID:22056140   PMID:22202776   PMID:22233545   PMID:22346733   PMID:22357932   PMID:22378764   PMID:22383895  
PMID:22396454   PMID:22412348   PMID:22550067   PMID:22554696   PMID:22560297   PMID:22627279   PMID:22669107   PMID:22682244   PMID:22698281   PMID:22872153   PMID:22912414   PMID:22983710  
PMID:22990867   PMID:23034635   PMID:23081664   PMID:23213411   PMID:23213481   PMID:23221368   PMID:23271656   PMID:23274954   PMID:23342175   PMID:23348697   PMID:23473982   PMID:23544137  
PMID:23552073   PMID:23651855   PMID:23707899   PMID:23742838   PMID:23999067   PMID:24114072   PMID:24194600   PMID:24318811   PMID:24558432   PMID:24576537   PMID:24585447   PMID:24697898  
PMID:24704359   PMID:24704361   PMID:24780629   PMID:24798330   PMID:24801048   PMID:24859004   PMID:24952961   PMID:24960041   PMID:25142465   PMID:25219788   PMID:25344072   PMID:25480920  
PMID:25511461   PMID:25528267   PMID:25536399   PMID:25775035   PMID:25813538   PMID:25869585   PMID:25904100   PMID:26494787   PMID:26496195   PMID:26534985   PMID:26791244   PMID:26801181  
PMID:26975355   PMID:27061115   PMID:27072135   PMID:27217206   PMID:27272319   PMID:27305836   PMID:27353389   PMID:27466203   PMID:27521049   PMID:27760115   PMID:27881714   PMID:27889317  
PMID:27924807   PMID:27930333   PMID:28118982   PMID:28182636   PMID:28188179   PMID:28191871   PMID:28619992   PMID:28669603   PMID:28839193   PMID:29138408   PMID:29140251   PMID:29168693  
PMID:29206913   PMID:29992973   PMID:30026265   PMID:30256721   PMID:30409165   PMID:30446628   PMID:30842446   PMID:31204172   PMID:31240264   PMID:31308417   PMID:31391582   PMID:31887266  
PMID:32219302   PMID:32439762   PMID:32521258   PMID:32523119   PMID:32546759   PMID:32743070   PMID:32876567   PMID:33171097   PMID:33692105   PMID:35547246   PMID:35803228   PMID:36197846  
PMID:37180804   PMID:37413993   PMID:37709743   PMID:37733651   PMID:38022561  


Genomics

Comparative Map Data
Nodal
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391061,253,751 - 61,261,117 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1061,253,751 - 61,261,117 (+)EnsemblGRCm39 Ensembl
GRCm381061,417,972 - 61,425,338 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1061,417,972 - 61,425,338 (+)EnsemblGRCm38mm10GRCm38
MGSCv371060,880,720 - 60,888,085 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361060,813,657 - 60,819,993 (+)NCBIMGSCv36mm8
Celera1062,519,279 - 62,526,659 (+)NCBICelera
Cytogenetic Map10B4NCBI
cM Map1032.21NCBI
NODAL
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381070,431,936 - 70,447,951 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1070,431,936 - 70,447,951 (-)EnsemblGRCh38hg38GRCh38
GRCh371072,191,692 - 72,207,707 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361071,862,077 - 71,871,429 (-)NCBINCBI36Build 36hg18NCBI36
Build 341071,862,076 - 71,871,429NCBI
Celera1065,472,123 - 65,481,898 (-)NCBICelera
Cytogenetic Map10q22.1NCBI
HuRef1066,185,532 - 66,195,306 (-)NCBIHuRef
CHM1_11072,473,912 - 72,483,685 (-)NCBICHM1_1
T2T-CHM13v2.01071,301,367 - 71,317,383 (-)NCBIT2T-CHM13v2.0
Nodal
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82029,911,258 - 29,919,659 (+)NCBIGRCr8
mRatBN7.22029,368,436 - 29,376,837 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2029,368,436 - 29,376,837 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2030,384,407 - 30,392,808 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02029,770,653 - 29,779,054 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02030,513,159 - 30,521,560 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02031,035,729 - 31,044,096 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2031,035,729 - 31,044,096 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02032,822,880 - 32,831,247 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42029,546,982 - 29,555,419 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12029,560,988 - 29,568,536 (+)NCBI
Celera2030,797,163 - 30,805,518 (+)NCBICelera
Cytogenetic Map20q11NCBI
Nodal
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543720,828,448 - 20,835,628 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495543720,828,448 - 20,835,486 (+)NCBIChiLan1.0ChiLan1.0
NODAL
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2882,580,547 - 82,596,805 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11082,585,868 - 82,602,126 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01066,906,866 - 66,916,938 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11069,433,959 - 69,443,972 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1069,433,959 - 69,443,972 (-)Ensemblpanpan1.1panPan2
NODAL
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1421,366,828 - 21,374,623 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl421,367,583 - 21,375,151 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha421,499,043 - 21,506,382 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0421,641,721 - 21,649,105 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl421,641,856 - 21,649,745 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1421,539,356 - 21,546,535 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0421,744,769 - 21,751,938 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0422,096,050 - 22,103,419 (-)NCBIUU_Cfam_GSD_1.0
Nodal
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440721359,674,355 - 59,686,268 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365218,171,146 - 8,178,705 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365218,171,146 - 8,178,802 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NODAL
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1473,353,258 - 73,360,654 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11473,350,358 - 73,357,064 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
NODAL
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1960,852,567 - 60,863,225 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl960,853,763 - 60,862,839 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604821,593,182 - 21,609,737 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Nodal
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247544,557,952 - 4,564,644 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247544,557,407 - 4,564,580 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Nodal
231 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:283
Count of miRNA genes:220
Interacting mature miRNAs:244
Transcripts:ENSMUST00000049339
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1357740Obsty3_mobesity 3 (mouse)Not determined108235478116190980Mouse
1301386Sysbp1_msystolic blood pressure 1 (mouse)Not determined101010826587401095Mouse
1357825Kidpq2_mkidney weight percentage QTL 2 (mouse)Not determined101270405184079784Mouse
1357656Hrtq3_mheart weight QTL 3 (mouse)Not determined101270405184079784Mouse
1357864Scfpq1_msubcutaneous fat pad percentage QTL 1 (mouse)Not determined101270405184079784Mouse
39128215Lwq17_mliver weight QTL 17 (mouse)101270405184079784Mouse
4141956Egq7_mearly growth QTL 7 (mouse)Not determined1270405184079784Mouse
4141943W6q6_mweight 6 weeks QTL 6 (mouse)Not determined1270405184079784Mouse
4142272W10q5_mweight 10 weeks QTL 5 (mouse)Not determined1270405184079784Mouse
4142380W3q11_mweight 3 weeks QTL 11 (mouse)Not determined1270405184079784Mouse
1302067Scc9_mcolon tumor susceptibility 9 (mouse)Not determined1018259333125575232Mouse
27226772Tibl13_mtibia length 13, 10 week (mouse)1018875748129635869Mouse
1558757Eae34_mexperimental allergic encephalomyelitis susceptibility 34 (mouse)Not determined1021408154114217230Mouse
1301003Lmblgq4_mlimb length QTL 4 (mouse)Not determined102159119268091639Mouse
26884403Cvht8_mcranial vault height 8, 16 week (mouse)102287589991035862Mouse
26884426Cvht1_mcranial vault height 1, 5 week (mouse)1024675898121035905Mouse
1300898Cfid_mcystic fibrosis intestinal distress (mouse)Not determined102972040363720483Mouse
10045632Heal16_mwound healing/regeneration 16 (mouse)Not determined103097449964974630Mouse
1357558Bmch4_mbone mechanical trait 4 (mouse)Not determined103157713665577284Mouse
27095920Pglq9_mpelvic girdle length QTL 9, 10 week (mouse)103377599670835830Mouse
27095911Pglq15_mpelvic girdle length QTL 15, 16 week (mouse)1039175996129635869Mouse
27226764Tibl19_mtibia length 19, 16 week (mouse)1039175996129635869Mouse
4141070Ltgq1_mliver triglyceride QTL 1 (mouse)Not determined4123732675237326Mouse
26884411Bzwq8_mbi-zygomatic width QTL 8, 10 week (mouse)1044876096115935905Mouse
26884407Bzwq14_mbi-zygomatic width QTL 14, 16 wee (mouse)1045476096120635905Mouse
26884421Cvht5_mcranial vault height 5, 10 week (mouse)104557609669135830Mouse
26884400Huml5_mhumerus length 5, 16 week (mouse)104627609669235830Mouse
4142313Angvq1_mangiogenesis by VEGF QTL 1 (mouse)Not determined4672040382491121Mouse
4141159Phl2_mprogressive hearing loss 2 (mouse)Not determined104797449970112651Mouse
1302150Bbaa18_mB.burgdorferi-associated arthritis 18 (mouse)Not determined104933801283338157Mouse
10045641Jckm3_mjuvenile cystic kidney modifier 3 (mouse)Not determined104984818783848412Mouse
1300597Skull14_mskull morphology 14 (mouse)Not determined104984818783848412Mouse
4142169Pbwg16_mpostnatal body weight growth 16 (mouse)Not determined104984818783848412Mouse
1357737Hpcr2_mhepatocarcinogen resistance 2 (mouse)Not determined104984822283848397Mouse
1301966Lifespan2_mlife span 2 (mouse)Not determined104984822283848397Mouse
1301502Eae17_msusceptibility to experimental allergic encephalomyelitis 17 (mouse)Not determined105109149085091639Mouse
1300882Ath17_matherosclerosis 17 (mouse)Not determined105109149085091639Mouse
1301380Cia8_mcollagen induced arthritis QTL 8 (mouse)Not determined105149340082491121Mouse
14746991Manh68_mmandible shape 68 (mouse)105228049786280497Mouse
1301787Bsc1_mbrain size control 1 (mouse)Not determined105851696992517096Mouse
26884450Sklq15_mskull length QTL 15, 16 week (mouse)1059335822122335905Mouse
13208560Wght9_mweight 9 (mouse)1059835822120835905Mouse

Markers in Region
BB283668  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381061,425,142 - 61,425,229UniSTSGRCm38
MGSCv371060,887,890 - 60,887,977UniSTSGRCm37
Celera1062,526,464 - 62,526,551UniSTS
Cytogenetic Map10B4UniSTS
cM Map1031.5UniSTS
Whitehead/MRC_RH10693.05UniSTS
Nodal  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381061,423,566 - 61,424,561UniSTSGRCm38
MGSCv371060,887,453 - 60,887,552UniSTSGRCm37
MGSCv371060,886,386 - 60,887,366UniSTSGRCm37
Celera1062,524,871 - 62,525,883UniSTS
Cytogenetic Map10B4UniSTS
cM Map1031.5UniSTS
cM Map1031.5UniSTS
D10Mit112.1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381061,424,705 - 61,424,899UniSTSGRCm38
MGSCv371060,887,453 - 60,887,647UniSTSGRCm37
Celera1062,526,027 - 62,526,221UniSTS
Cytogenetic Map10B4UniSTS
cM Map1031.5UniSTS
cM Map10 UniSTS
Whitehead Genetic1023.0UniSTS
D10Mit112  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381061,424,897 - 61,425,027UniSTSGRCm38
MGSCv371060,887,645 - 60,887,775UniSTSGRCm37
Celera1062,526,219 - 62,526,349UniSTS
Cytogenetic Map10B4UniSTS
cM Map1031.5UniSTS
Whitehead Genetic1023.0UniSTS
D10Mit112.2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381061,425,078 - 61,425,193UniSTSGRCm38
MGSCv371060,887,826 - 60,887,941UniSTSGRCm37
Celera1062,526,400 - 62,526,515UniSTS
Cytogenetic Map10B4UniSTS
cM Map1031.5UniSTS
cM Map10 UniSTS
Whitehead Genetic1023.0UniSTS
GDB:533003  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381061,421,412 - 61,421,464UniSTSGRCm38
GRCm38523,364,604 - 23,364,748UniSTSGRCm38
MGSCv37522,870,422 - 22,870,566UniSTSGRCm37
MGSCv371060,884,160 - 60,884,212UniSTSGRCm37
Celera1062,522,719 - 62,522,771UniSTS
Cytogenetic Map10B4UniSTS
Cytogenetic Map5A3UniSTS
cM Map1031.5UniSTS
Nodal  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381061,423,638 - 61,424,618UniSTSGRCm38
MGSCv371060,886,386 - 60,887,366UniSTSGRCm37
Celera1062,524,943 - 62,525,940UniSTS
Cytogenetic Map10B4UniSTS
cM Map1031.5UniSTS
Nodal  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map10B4UniSTS
Nodal  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381061,424,705 - 61,424,804UniSTSGRCm38
MGSCv371060,887,453 - 60,887,552UniSTSGRCm37
Celera1062,526,027 - 62,526,126UniSTS
Cytogenetic Map10B4UniSTS


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000049339   ⟹   ENSMUSP00000039653
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1061,253,751 - 61,261,117 (+)Ensembl
GRCm38.p6 Ensembl1061,417,972 - 61,425,338 (+)Ensembl
RefSeq Acc Id: NM_013611   ⟹   NP_038639
RefSeq Status: REVIEWED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391061,253,751 - 61,261,117 (+)NCBI
GRCm381061,417,972 - 61,425,338 (+)NCBI
MGSCv371060,880,720 - 60,888,085 (+)RGD
Celera1062,519,279 - 62,526,659 (+)RGD
cM Map10 ENTREZGENE
Sequence:
Reference Protein Sequences
RefSeq Acc Id: NP_038639   ⟸   NM_013611
- Peptide Label: preproprotein
- UniProtKB: Q8BH87 (UniProtKB/Swiss-Prot),   P43021 (UniProtKB/Swiss-Prot),   A0PK81 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSMUSP00000039653   ⟸   ENSMUST00000049339
Protein Domains
TGF-beta family profile

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P43021-F1-model_v2 AlphaFold P43021 1-354 view protein structure

Promoters
RGD ID:6819671
Promoter ID:MM_KWN:4265
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:ES_Cell
Transcripts:OTTMUST00000050919
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361060,880,371 - 60,881,172 (+)MPROMDB
RGD ID:8672092
Promoter ID:EPDNEW_M14077
Type:single initiation site
Name:Nodal_1
Description:Mus musculus nodal , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381061,418,288 - 61,418,348EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:97359 AgrOrtholog
Ensembl Genes ENSMUSG00000037171 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000049339 ENTREZGENE
  ENSMUST00000049339.7 UniProtKB/Swiss-Prot
Gene3D-CATH 2.10.90.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Cystine-knot_cytokine UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TGF-b_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TGF-beta-rel UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TGFb_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:18119 UniProtKB/Swiss-Prot
MGD MGI:97359 ENTREZGENE
NCBI Gene 18119 ENTREZGENE
PANTHER NODAL HOMOLOG UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR11848 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam TGF_beta UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Nodal PhenoGen
PROSITE TGF_BETA_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TGF_BETA_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART TGFB UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF57501 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0PK81 ENTREZGENE, UniProtKB/TrEMBL
  NODAL_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
  Q8BH87 ENTREZGENE
UniProt Secondary Q8BH87 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2024-04-02 Nodal  nodal growth differentiation factor  Nodal  nodal  Symbol and/or name change 5135510 APPROVED