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Gene: C4a (complement C4A) Rattus norvegicus
Symbol: C4a
Name: complement C4A
Description: Predicted to have complement component C1q complex binding activity. Predicted to be involved in complement activation and positive regulation of apoptotic cell clearance. Localizes to extracellular space. Human ortholog(s) of this gene implicated in autistic disorder; autoimmune hypersensitivity disease (multiple); complement deficiency (multiple); renal cell carcinoma; and rheumatoid arthritis. Orthologous to several human genes including C4B (complement C4B (Chido blood group)); PARTICIPATES IN classical complement pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran; 2,4-dinitrotoluene.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: C4; C4-1; C4b; complement C4; complement C4-like; complement component 4 (within H-2S); complement component 4, gene 1; complement component 4a; complement component 4A (Rodgers blood group); complement component 4B (Chido blood group); complement component 4B (Childo blood group); LOC102549354
Homo sapiens (human) : C4A (complement C4A (Rodgers blood group))  HGNC  Alliance
Mus musculus (house mouse) : C4a (complement component 4A (Rodgers blood group))  MGI  Alliance
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : C4a (complement C4A (Rodgers blood group))
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
NCBI Annotation Information: Annotation category: suggests misassembly; Annotation category: partial on reference assembly
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.0202,651,599 - 2,678,183 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl202,651,599 - 2,678,141 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0206,573,225 - 6,587,996 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.0204,754,468 - 4,755,821 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4204,106,123 - 4,145,904NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1204,106,391 - 4,316,103NCBI
Celera204,010,655 - 4,024,973 (-)NCBICelera
Cytogenetic Map20p12NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on C4a
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 620005
Created: 2002-08-06
Species: Rattus norvegicus
Last Modified: 2020-06-09
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.