C4a (complement C4A) - Rat Genome Database

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Gene: C4a (complement C4A) Rattus norvegicus
Analyze
Symbol: C4a
Name: complement C4A
RGD ID: 620005
Description: Predicted to enable complement component C1q complex binding activity. Predicted to be involved in complement activation and positive regulation of apoptotic cell clearance. Located in extracellular space. Human ortholog(s) of this gene implicated in Graves' disease; complement component 4a deficiency; renal cell carcinoma; systemic lupus erythematosus; and vitiligo. Orthologous to several human genes including C4A (complement C4A (Rodgers blood group)); PARTICIPATES IN classical complement pathway; INTERACTS WITH 17beta-estradiol; 17beta-estradiol 3-benzoate; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: C4; C4-1; C4b; complement C4; complement C4-like; complement component 4 (within H-2S); complement component 4, gene 1; complement component 4a; complement component 4A (Rodgers blood group); complement component 4B (Chido blood group); complement component 4B (Childo blood group); LOC102549354; LOC103689965
RGD Orthologs
Human
Mouse
Squirrel
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2204,005,731 - 4,020,083 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl204,005,731 - 4,020,080 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx204,705,672 - 4,720,035 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0204,067,420 - 4,081,783 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0204,604,594 - 4,618,950 (+)NCBIRnor_WKY
Rnor_6.0202,651,599 - 2,678,183 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl202,651,599 - 2,678,141 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0206,573,225 - 6,587,996 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.0204,754,468 - 4,755,821 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4204,106,123 - 4,145,904NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1204,106,391 - 4,316,103NCBI
Celera204,010,655 - 4,024,973 (-)NCBICelera
Cytogenetic Map20p12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. The orphan receptor C5L2 has high affinity binding sites for complement fragments C5a and C5a des-Arg(74). Cain SA and Monk PN, J Biol Chem 2002 Mar 1;277(9):7165-9. Epub 2001 Dec 31.
2. Complement C4 protein expression by rat hepatic stellate cells. Fimmel CJ, etal., J Immunol. 1996 Sep 15;157(6):2601-9.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. [Enzyme immunoassay of masked complement component C4 deficiency in patients with urogenital Chlamydia infection]. Gora NV, etal., Zh Mikrobiol Epidemiol Immunobiol. 2011 May-Jun;(3):76-80.
5. Inhibition of classical complement activation attenuates liver ischaemia and reperfusion injury in a rat model. Heijnen BH, etal., Clin Exp Immunol. 2006 Jan;143(1):15-23.
6. [Masked deficiency of C4 component of complement in patients with chronic gastrointestinal tract diseases of different etiology]. Kozlov LV, etal., Zh Mikrobiol Epidemiol Immunobiol. 2011 Jul-Aug;(4):61-5.
7. Association between copy number variation of complement component C4 and Graves' disease. Liu YH, etal., J Biomed Sci. 2011 Sep 26;18:71.
8. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
9. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
10. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
11. GOA pipeline RGD automated data pipeline
12. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
13. Comprehensive gene review and curation RGD comprehensive gene curation
14. The rat expresses two complement factor C4 proteins, but only one isotype is expressed in the liver. Roos C, etal., J Immunol. 2005 Jan 15;174(2):970-5.
15. Immunoglobulins and complement factor C4 in adult rhinosinusitis. Seppanen M, etal., Clin Exp Immunol. 2006 Aug;145(2):219-27.
16. Gene copy-number variation and associated polymorphisms of complement component C4 in human systemic lupus erythematosus (SLE): low copy number is a risk factor for and high copy number is a protective factor against SLE susceptibility in European Americans. Yang Y, etal., Am J Hum Genet. 2007 Jun;80(6):1037-54. Epub 2007 Apr 26.
17. Genetic deficiency of complement isoforms C4A or C4B predicts improved survival of metastatic renal cell carcinoma. Zafar GI, etal., J Urol. 2009 Mar;181(3):1028-34; discussion 1034. Epub 2009 Jan 16.
Additional References at PubMed
PMID:1438267   PMID:2395880   PMID:3023818   PMID:3262196   PMID:8133084   PMID:12136338   PMID:15060079   PMID:17204478   PMID:17345707   PMID:19302245   PMID:23613499   PMID:25645918  
PMID:26219954   PMID:26316108   PMID:26814963  


Genomics

Comparative Map Data
C4a
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2204,005,731 - 4,020,083 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl204,005,731 - 4,020,080 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx204,705,672 - 4,720,035 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0204,067,420 - 4,081,783 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0204,604,594 - 4,618,950 (+)NCBIRnor_WKY
Rnor_6.0202,651,599 - 2,678,183 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl202,651,599 - 2,678,141 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0206,573,225 - 6,587,996 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.0204,754,468 - 4,755,821 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4204,106,123 - 4,145,904NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1204,106,391 - 4,316,103NCBI
Celera204,010,655 - 4,024,973 (-)NCBICelera
Cytogenetic Map20p12NCBI
C4A
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38631,982,057 - 32,002,681 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl631,982,057 - 32,002,681 (+)EnsemblGRCh38hg38GRCh38
GRCh37631,949,834 - 31,970,458 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36632,090,549 - 32,111,173 (+)NCBINCBI36Build 36hg18NCBI36
Build 34632,090,549 - 32,111,173NCBI
Celera633,549,596 - 33,570,218 (+)NCBICelera
Cytogenetic Map6p21.33NCBI
HuRef631,736,844 - 31,746,589 (+)NCBIHuRef
CHM1_1631,951,915 - 31,972,655 (+)NCBICHM1_1
T2T-CHM13v2.0631,835,263 - 31,855,887 (+)NCBIT2T-CHM13v2.0
C4a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391735,028,069 - 35,042,436 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1735,028,069 - 35,042,440 (-)EnsemblGRCm39 Ensembl
GRCm381734,809,092 - 34,823,460 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1734,809,092 - 34,823,464 (-)EnsemblGRCm38mm10GRCm38
MGSCv371734,946,037 - 34,960,399 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361734,417,150 - 34,431,510 (-)NCBIMGSCv36mm8
Celera1737,904,407 - 37,918,769 (-)NCBICelera
Cytogenetic Map17B1NCBI
cM Map1718.37NCBI
LOC101975827
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494635,991,270 - 36,005,133 (+)NCBIHiC_Itri_2
SpeTri2.0NW_0049367271,556,204 - 1,570,084 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0

Variants

.
Variants in C4a
64 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:93
Count of miRNA genes:76
Interacting mature miRNAs:83
Transcripts:ENSRNOT00000072377
Prediction methods:Microtar, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1354642Despr15Despair related QTL 150.0027locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)20124159021Rat
1600382Edcs3Endometrial carcinoma susceptibility QTL33.50.003uterus morphology trait (VT:0001120)percentage of study population developing endometrioid carcinoma during a period of time (CMO:0001759)20125159026Rat
2317851Alcrsp22Alcohol response QTL 223.20.05response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)20127339237Rat
1641893Alcrsp7Alcohol response QTL 7response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)20127339237Rat
8694189Bw153Body weight QTL 1533.130.001body mass (VT:0001259)body weight gain (CMO:0000420)20129191651Rat
9590275Scort15Serum corticosterone level QTL 153.480.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)20129191651Rat
7411650Foco23Food consumption QTL 2320.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)20129191651Rat
9590109Sffal8Serum free fatty acids level QTL 85.320.01blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)20129191651Rat
9589155Insul32Insulin level QTL 326.380.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)20129191651Rat
6893685Bw111Body weight QTL 1112.70.004body mass (VT:0001259)body weight (CMO:0000012)20132578807Rat
7411668Foco32Food consumption QTL 3280.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)20136600972Rat
9590252Scort12Serum corticosterone level QTL 1220.460.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)20136600972Rat
2305926Iddm37Insulin dependent diabetes mellitus QTL 376blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)20152784246527842Rat
2306850Pia40Pristane induced arthritis QTL 400.0001joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)2015279595304575Rat
1641915Colcr9Colorectal carcinoma resistance QTL 92.970.0024intestine integrity trait (VT:0010554)benign colorectal tumor number (CMO:0001795)20153065546530655Rat
1598816Memor12Memory QTL 122.4exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)20260683647606836Rat
61448Ciaa1CIA Autoantibody QTL 1300.001blood autoantibody amount (VT:0003725)calculated serum anti-rat type 2 collagen autoantibody titer (CMO:0001281)2026463954597031Rat
61472Aia1Adjuvant induced arthritis QTL 1180.001joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)2026463954597031Rat
2317057Aia27Adjuvant induced arthritis QTL 272.83joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)20289259726381954Rat
1300152Bp195Blood pressure QTL 1953.46arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2036216499243559Rat
1331772Cdexp2CD45RC expression in CD8 T cells QTL 25.7CD8-positive T cell quantity (VT:0008077)blood CD45RC(high) CD8 T cell count to CD45RC(low) CD8 T cell count ratio (CMO:0001990)20362164910078919Rat
737973Pia21Pristane induced arthritis QTL 214.8joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)2036216564606812Rat
61432Cia1Collagen induced arthritis QTL 1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)20362165614101050Rat

Markers in Region
D20Yum59  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2204,031,068 - 4,031,242 (-)MAPPERmRatBN7.2
Rnor_6.0204,481,956 - 4,482,129NCBIRnor6.0
Rnor_5.0206,561,312 - 6,561,485UniSTSRnor5.0
RGSC_v3.4204,132,407 - 4,132,580UniSTSRGSC3.4
Celera203,998,885 - 3,999,058UniSTS
Cytogenetic Map20p12UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system nervous system renal system reproductive system respiratory system
High
Medium
Low
Below cutoff 1 1 34 22 16 22 3 1 10 9

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000000514   ⟹   ENSRNOP00000000514
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl204,005,731 - 4,020,080 (+)Ensembl
Rnor_6.0 Ensembl204,495,465 - 4,508,214 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000072377   ⟹   ENSRNOP00000066721
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl202,651,702 - 2,678,141 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000078871   ⟹   ENSRNOP00000068572
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl202,651,599 - 2,652,952 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000083833   ⟹   ENSRNOP00000069352
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl202,667,524 - 2,678,141 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000086027   ⟹   ENSRNOP00000069699
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl204,005,731 - 4,020,080 (+)Ensembl
Rnor_6.0 Ensembl204,302,347 - 4,508,197 (-)Ensembl
RefSeq Acc Id: NM_031504   ⟹   NP_113692
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2204,005,731 - 4,020,083 (+)NCBI
Rnor_6.0202,651,599 - 2,678,183 (-)NCBI
Rnor_5.0204,754,468 - 4,755,821 (-)NCBI
Rnor_5.0206,573,225 - 6,587,996 (-)NCBI
RGSC_v3.4204,106,123 - 4,145,904 (+)RGD
Celera204,010,655 - 4,024,973 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_113692 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAM14719 (Get FASTA)   NCBI Sequence Viewer  
  AAN72415 (Get FASTA)   NCBI Sequence Viewer  
  CAE83967 (Get FASTA)   NCBI Sequence Viewer  
  P08649 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_113692   ⟸   NM_031504
- Peptide Label: precursor
- UniProtKB: P08649 (UniProtKB/Swiss-Prot),   Q6MG79 (UniProtKB/TrEMBL),   A0A0G2JW12 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000069352   ⟸   ENSRNOT00000083833
RefSeq Acc Id: ENSRNOP00000066721   ⟸   ENSRNOT00000072377
RefSeq Acc Id: ENSRNOP00000068572   ⟸   ENSRNOT00000078871
RefSeq Acc Id: ENSRNOP00000069699   ⟸   ENSRNOT00000086027
RefSeq Acc Id: ENSRNOP00000000514   ⟸   ENSRNOT00000000514
Protein Domains
Anaphylatoxin-like   NTR

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-A0A0G2JW12-F1-model_v2 AlphaFold A0A0G2JW12 1-1737 view protein structure
AF-P08649-F1-model_v2 AlphaFold P08649 1-1737 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620005 AgrOrtholog
BioCyc Gene G2FUF-4597 BioCyc
Ensembl Genes ENSRNOG00000000443 Ensembl
  ENSRNOG00000047657 Ensembl
  ENSRNOG00000066573 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000000514.6 UniProtKB/TrEMBL
  ENSRNOP00000069699 ENTREZGENE
  ENSRNOP00000069699.2 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000000514.7 UniProtKB/TrEMBL
  ENSRNOT00000086027 ENTREZGENE
  ENSRNOT00000086027.2 UniProtKB/TrEMBL
Gene3D-CATH 2.40.50.120 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  2.60.40.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  2.60.40.690 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro A-macroglobulin_rcpt-bd UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  A-macroglobulin_rcpt-bd_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  A2M_N_BRD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Alpha-macroglobulin_TED UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Anaphylatoxin/fibulin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Anaphylatoxin_comp_syst UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Anaphylatoxn_comp_syst_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Complement_C4A UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig-like_fold UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Macroglobln_a2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MacrogloblnA2_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MG2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MG3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MG4 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Netrin_domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Netrin_module_non-TIMP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Terpenoid_cyclase/PrenylTrfase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TIMP-like_OB-fold UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:24233 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 24233 ENTREZGENE
PANTHER PTHR11412:SF86 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam A2M UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  A2M_BRD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  A2M_recep UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ANATO UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MG2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MG3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MG4 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NTR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TED_complement UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen C4a PhenoGen
PRINTS ANAPHYLATOXN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE ALPHA_2_MACROGLOBULIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ANAPHYLATOXIN_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ANAPHYLATOXIN_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NTR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART A2M UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  A2M_N_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  A2M_recep UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ANATO UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  C345C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF47686 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF48239 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF49410 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF50242 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0G2JW12 ENTREZGENE
  CO4_RAT UniProtKB/Swiss-Prot
  F1LNM4_RAT UniProtKB/TrEMBL
  P08649 ENTREZGENE
  Q6MG79 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary A0A0G2JW12 UniProtKB/TrEMBL
  Q62895 UniProtKB/Swiss-Prot
  Q8R403 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-03-09 C4a  complement C4A  LOC103689965  complement C4-like  Data Merged 737654 PROVISIONAL
2018-05-07 C4a  complement C4A  C4a  complement component 4A (Rodgers blood group)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2015-07-29 C4a  complement component 4A (Rodgers blood group)  LOC102549354  complement C4-like  Data Merged 737654 PROVISIONAL
2014-08-25 LOC103689965  complement C4-like      Symbol and Name status set to provisional 70820 PROVISIONAL
2013-12-18 LOC102549354  complement C4-like      Symbol and Name status set to provisional 70820 PROVISIONAL
2012-02-22 C4a  complement component 4A (Rodgers blood group)  C4b  complement component 4B (Chido blood group)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2010-04-20 C4b  complement component 4B (Chido blood group)  C4b  complement component 4B (Childo blood group)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-02-22 C4b  complement component 4B (Childo blood group)  C4a  complement component 4a  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2003-04-09 C4a  complement component 4a      Symbol and Name updated 629477 APPROVED
2003-03-10 C4a  complement component 4a  C4  Complement component 4  Data Merged 628472 PROVISIONAL
2002-08-07 C4a        Symbol and Name status set to provisional 70820 PROVISIONAL
2002-06-10 C4  Complement component 4      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_mapping maps to the MHC RT1 complex 1300431