Srpk1 (SRSF protein kinase 1) - Rat Genome Database

Name: Srpk1
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

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Gene: Srpk1 (SRSF protein kinase 1) Rattus norvegicus

Analyze

Symbol:

Srpk1

Name:

SRSF protein kinase 1

RGD ID:

1308272

Description:

Predicted to enable ATP binding activity; magnesium ion binding activity; and protein serine/threonine kinase activity. Predicted to be involved in several processes, including intracellular signal transduction; regulation of mRNA processing; and regulation of viral genome replication. Predicted to be located in cytosol; nuclear speck; and plasma membrane. Predicted to be part of chromatin. Orthologous to human SRPK1 (SRSF protein kinase 1); INTERACTS WITH (+)-schisandrin B; acrylamide; benzo[a]pyrene.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

LOC361811; MGC116186; serine/arginine-rich protein specific kinase 1; serine/threonine-protein kinase SRPK1; SFRS protein kinase 1

RGD Orthologs

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	SRPK1 (SRSF protein kinase 1)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, Treefam
Mus musculus (house mouse):	Srpk1 (serine/arginine-rich protein specific kinase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Srpk1 (SRSF protein kinase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	SRPK1 (SRSF protein kinase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	SRPK1 (SRSF protein kinase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Srpk1 (SRSF protein kinase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	SRPK1 (SRSF protein kinase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	SRPK1 (SRSF protein kinase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Srpk1 (SRSF protein kinase 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Homo sapiens (human):	SRPK1 (SRSF protein kinase 1)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Srpk1 (serine/arginine-rich protein specific kinase 1)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	srpk1a (SRSF protein kinase 1a)	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	srpk1b (SRSF protein kinase 1b)	Alliance	DIOPT (Ensembl Compara\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	CG8565	Alliance	DIOPT (OrthoInspector\|PANTHER)
Saccharomyces cerevisiae (baker's yeast):	SKY1	Alliance	DIOPT (InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|SonicParanoid)
Caenorhabditis elegans (roundworm):	spk-1	Alliance	DIOPT (OrthoFinder\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	Srpk79D	Alliance	DIOPT (OrthoInspector\|PhylomeDB)
Xenopus tropicalis (tropical clawed frog):	srpk1	Alliance	DIOPT (Ensembl Compara\|OMA\|OrthoFinder\|PANTHER\|PhylomeDB)

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	20	6,645,809 - 6,682,448 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	20	6,645,809 - 6,682,134 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	20	7,360,437 - 7,394,786 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	20	6,722,274 - 6,756,623 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	20	7,202,846 - 7,237,239 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	20	5,829,412 - 5,865,877 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	20	5,831,119 - 5,865,854 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	20	7,866,852 - 7,901,153 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	20	6,829,410 - 6,870,877 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	20	6,829,636 - 6,871,104 (-)	NCBI
Celera	20	8,203,854 - 8,238,077 (-)	NCBI		Celera
Cytogenetic Map	20	p12	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

genetic disease (ISO)

proteasome-associated autoinflammatory syndrome 1 (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(+)-schisandrin B (EXP)

1,2-dimethylhydrazine (ISO)

17beta-estradiol (ISO)

2,3,7,8-tetrachlorodibenzodioxine (ISO)

2,4,6-tribromophenol (ISO)

2-hydroxypropanoic acid (ISO)

2-methylcholine (ISO)

3,4-methylenedioxymethamphetamine (ISO)

acrolein (ISO)

acrylamide (EXP)

aflatoxin B1 (ISO)

all-trans-retinoic acid (ISO)

alpha-pinene (ISO)

arsenite(3-) (ISO)

benzo[a]pyrene (EXP,ISO)

benzo[a]pyrene diol epoxide I (ISO)

bisphenol A (EXP,ISO)

butyric acid (ISO)

C60 fullerene (EXP)

cadmium atom (ISO)

cadmium dichloride (EXP,ISO)

caffeine (ISO)

calcitriol (ISO)

CGP 52608 (ISO)

choline (ISO)

cisplatin (ISO)

copper atom (ISO)

copper(0) (ISO)

crocidolite asbestos (ISO)

decabromodiphenyl ether (EXP)

Diisodecyl phthalate (ISO)

elemental selenium (ISO)

enzyme inhibitor (ISO)

fenthion (ISO)

folic acid (ISO)

formaldehyde (ISO)

furan (EXP)

gentamycin (EXP)

isoflurane (ISO)

ivermectin (ISO)

ketamine (EXP)

L-methionine (ISO)

lead(0) (ISO)

menadione (ISO)

methidathion (ISO)

N-nitrosodiethylamine (EXP)

oxaliplatin (ISO)

ozone (ISO)

paraquat (ISO)

protein kinase inhibitor (ISO)

rac-lactic acid (ISO)

resveratrol (ISO)

selenium atom (ISO)

sevoflurane (ISO)

sodium arsenite (ISO)

tetrachloromethane (EXP,ISO)

thioacetamide (EXP)

vitamin E (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

chromosome segregation (ISO)

intracellular signal transduction (IBA,ISO)

negative regulation of viral genome replication (ISO)

positive regulation of viral genome replication (ISO)

regulation of mRNA processing (IBA,ISO)

spliceosomal complex assembly (IBA)

Cellular Component

chromatin (ISO)

cytoplasm (IBA,ISO)

cytosol (IEA,ISO)

nuclear speck (ISO)

nucleoplasm (ISO)

nucleus (IBA,ISO)

plasma membrane (IEA,ISO)

Molecular Function

ATP binding (ISO)

magnesium ion binding (ISO)

protein binding (ISO)

protein serine/threonine kinase activity (IBA,ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Rat ISS GO annotations from GOA human gene data--August 2006	GOA data from the GO Consortium
3.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
4.	GOA pipeline	RGD automated data pipeline
5.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:8208298	PMID:9237760	PMID:9446799	PMID:11509566	PMID:12417631	PMID:12477932	PMID:15034300	PMID:20498328	PMID:22681889	PMID:28076779	PMID:30101479	PMID:33167866

Genomics

Comparative Map Data

Srpk1
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	20	6,645,809 - 6,682,448 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	20	6,645,809 - 6,682,134 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	20	7,360,437 - 7,394,786 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	20	6,722,274 - 6,756,623 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	20	7,202,846 - 7,237,239 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	20	5,829,412 - 5,865,877 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	20	5,831,119 - 5,865,854 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	20	7,866,852 - 7,901,153 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	20	6,829,410 - 6,870,877 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	20	6,829,636 - 6,871,104 (-)	NCBI
Celera	20	8,203,854 - 8,238,077 (-)	NCBI		Celera
Cytogenetic Map	20	p12	NCBI

SRPK1
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	6	35,832,966 - 35,921,098 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	6	35,832,966 - 35,921,342 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	6	35,800,743 - 35,888,875 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	6	35,908,789 - 35,996,934 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	6	35,908,788 - 35,996,934	NCBI
Celera	6	37,355,384 - 37,443,522 (-)	NCBI		Celera
Cytogenetic Map	6	p21.31	NCBI
HuRef	6	35,518,955 - 35,608,798 (-)	NCBI		HuRef
CHM1_1	6	35,802,571 - 35,890,700 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	6	35,653,298 - 35,741,415 (-)	NCBI		T2T-CHM13v2.0

Srpk1
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	17	28,806,622 - 28,841,795 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	17	28,806,622 - 28,841,683 (-)	Ensembl		GRCm39 Ensembl
GRCm38	17	28,587,648 - 28,622,528 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	17	28,587,648 - 28,622,709 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	17	28,726,537 - 28,759,399 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	17	28,317,181 - 28,350,043 (-)	NCBI		MGSCv36	mm8
Celera	17	29,143,627 - 29,176,732 (-)	NCBI		Celera
Cytogenetic Map	17	A3.3	NCBI
cM Map	17	14.78	NCBI

Srpk1
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0	NW_004955437	3,664,290 - 3,729,832 (-)	NCBI	ChiLan1.0	ChiLan1.0

SRPK1
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1	6	46,167,467 - 46,256,406 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	6	35,393,290 - 35,480,530 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	6	36,596,292 - 36,683,363 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	6	36,598,552 - 36,683,257 (-)	Ensembl	panpan1.1		panPan2

SRPK1
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	12	4,941,292 - 5,029,580 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	12	4,917,297 - 5,030,255 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	12	4,956,320 - 5,050,126 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	12	5,283,163 - 5,377,056 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	12	5,285,510 - 5,377,171 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	12	4,938,758 - 5,032,561 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	12	5,017,870 - 5,111,606 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	12	5,118,941 - 5,211,812 (-)	NCBI		UU_Cfam_GSD_1.0

Srpk1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404946	40,484,027 - 40,552,985 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936476	23,407,226 - 23,476,579 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936476	23,407,226 - 23,476,203 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

SRPK1
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	7	31,645,755 - 31,701,087 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	7	31,645,753 - 31,701,305 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	7	36,573,709 - 36,638,641 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

SRPK1
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	17	36,196,763 - 36,287,166 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	17	36,196,898 - 36,284,900 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666044	35,781,007 - 35,871,348 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Srpk1
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624754	21,679,578 - 21,743,913 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624754	21,679,597 - 21,743,951 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Srpk1
191 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	49
Count of miRNA genes:	46
Interacting mature miRNAs:	48
Transcripts:	ENSRNOT00000000612
Prediction methods:	Miranda, Rnahybrid
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1354642	Despr15	Despair related QTL 15		0.0027	locomotor behavior trait (VT:0001392)	amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)	20	1	24159021	Rat
1600382	Edcs3	Endometrial carcinoma susceptibility QTL3	3.5	0.003	uterus morphology trait (VT:0001120)	percentage of study population developing endometrioid carcinoma during a period of time (CMO:0001759)	20	1	25159026	Rat
2317851	Alcrsp22	Alcohol response QTL 22	3.2	0.05	response to alcohol trait (VT:0010489)	duration of loss of righting reflex (CMO:0002289)	20	1	27339237	Rat
1641893	Alcrsp7	Alcohol response QTL 7			response to alcohol trait (VT:0010489)	duration of loss of righting reflex (CMO:0002289)	20	1	27339237	Rat
8694189	Bw153	Body weight QTL 153	3.13	0.001	body mass (VT:0001259)	body weight gain (CMO:0000420)	20	1	29191651	Rat
9590275	Scort15	Serum corticosterone level QTL 15	3.48	0.001	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	20	1	29191651	Rat
7411650	Foco23	Food consumption QTL 23	20.7	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	20	1	29191651	Rat
9590109	Sffal8	Serum free fatty acids level QTL 8	5.32	0.01	blood free fatty acid amount (VT:0001553)	plasma free fatty acids level (CMO:0000546)	20	1	29191651	Rat
9589155	Insul32	Insulin level QTL 32	6.38	0.001	blood insulin amount (VT:0001560)	plasma insulin level (CMO:0000342)	20	1	29191651	Rat
6893685	Bw111	Body weight QTL 111	2.7	0.004	body mass (VT:0001259)	body weight (CMO:0000012)	20	1	32578807	Rat
7411668	Foco32	Food consumption QTL 32	8	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	20	1	36600972	Rat
9590252	Scort12	Serum corticosterone level QTL 12	20.46	0.001	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	20	1	36600972	Rat
2305926	Iddm37	Insulin dependent diabetes mellitus QTL 37	6		blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	20	1527842	46527842	Rat
1641915	Colcr9	Colorectal carcinoma resistance QTL 9	2.97	0.0024	intestine integrity trait (VT:0010554)	benign colorectal tumor number (CMO:0001795)	20	1530655	46530655	Rat
1598816	Memor12	Memory QTL 12	2.4		exploratory behavior trait (VT:0010471)	average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)	20	2606836	47606836	Rat
2317057	Aia27	Adjuvant induced arthritis QTL 27	2.83		joint integrity trait (VT:0010548)	right rear ankle joint diameter (CMO:0002150)	20	2892597	26381954	Rat
1300152	Bp195	Blood pressure QTL 195	3.46		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	20	3621649	9243559	Rat
1331772	Cdexp2	CD45RC expression in CD8 T cells QTL 2	5.7		CD8-positive T cell quantity (VT:0008077)	blood CD45RC(high) CD8 T cell count to CD45RC(low) CD8 T cell count ratio (CMO:0001990)	20	3621649	10078919	Rat
61432	Cia1	Collagen induced arthritis QTL 1			joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	20	3621656	14101050	Rat
61474	Eae1	Experimental allergic encephalomyelitis QTL 1	3		nervous system integrity trait (VT:0010566)	experimental autoimmune encephalomyelitis severity score (CMO:0001419)	20	4606607	6691706	Rat
4889857	Pur27	Proteinuria QTL 27	12.2	0.001	urine total protein amount (VT:0000032)	urine total protein excretion rate (CMO:0000756)	20	4606607	17617956	Rat
1558640	Prcs2	Prostate cancer susceptibility QTL 2	3.3		prostate integrity trait (VT:0010571)	percentage of study population developing ventral prostate tumorous lesions during a period of time (CMO:0000943)	20	4606607	17617956	Rat

Markers in Region

RH128309

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	20	6,647,627 - 6,647,816 (+)	MAPPER	mRatBN7.2
Rnor_6.0	20	5,831,231 - 5,831,419	NCBI	Rnor6.0
Rnor_5.0	20	7,866,761 - 7,866,949	UniSTS	Rnor5.0
RGSC_v3.4	20	6,829,319 - 6,829,507	UniSTS	RGSC3.4
Celera	20	8,203,763 - 8,203,951	UniSTS
RH 3.4 Map	20	94.2	UniSTS
Cytogenetic Map	20	p12	UniSTS

BE120383

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	20	6,655,703 - 6,655,856 (+)	MAPPER	mRatBN7.2
Rnor_6.0	20	5,839,313 - 5,839,465	NCBI	Rnor6.0
Rnor_5.0	20	7,874,765 - 7,874,917	UniSTS	Rnor5.0
RGSC_v3.4	20	6,843,594 - 6,843,746	UniSTS	RGSC3.4
Celera	20	8,211,686 - 8,211,838	UniSTS
RH 3.4 Map	20	77.33	UniSTS
Cytogenetic Map	20	p12	UniSTS

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium	3	36	56	40	19	40	6	9	74	35	41	11	6
Low		7	1	1		1	2	2					2
Below cutoff

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001025726	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017601678	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039098820	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039098821	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	BC090554	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC099089	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473988	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ225598	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JACYVU010000324	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSRNOT00000000612 ⟹ ENSRNOP00000000612

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	20	6,645,809 - 6,682,098 (-)	Ensembl
Rnor_6.0 Ensembl	20	5,831,573 - 5,865,775 (-)	Ensembl

RefSeq Acc Id:

ENSRNOT00000092514

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	20	6,658,519 - 6,682,134 (-)	Ensembl
Rnor_6.0 Ensembl	20	5,840,827 - 5,851,288 (-)	Ensembl

RefSeq Acc Id:

ENSRNOT00000092641 ⟹ ENSRNOP00000075811

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	20	6,645,809 - 6,670,457 (-)	Ensembl
Rnor_6.0 Ensembl	20	5,831,119 - 5,865,854 (-)	Ensembl

RefSeq Acc Id:

ENSRNOT00000100033 ⟹ ENSRNOP00000092552

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	20	6,657,493 - 6,682,134 (-)	Ensembl

RefSeq Acc Id:

ENSRNOT00000105949 ⟹ ENSRNOP00000076564

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	20	6,645,815 - 6,682,105 (-)	Ensembl

RefSeq Acc Id:

NM_001025726 ⟹ NP_001020897

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	20	6,647,719 - 6,682,107 (-)	NCBI
Rnor_6.0	20	5,831,322 - 5,865,854 (-)	NCBI
Rnor_5.0	20	7,866,852 - 7,901,153 (-)	NCBI
RGSC_v3.4	20	6,829,410 - 6,870,877 (-)	RGD
Celera	20	8,203,854 - 8,238,077 (-)	RGD

Sequence:

show sequence

CTGGGATTAGGGCCGCGGCGGGAGCCCGAGTCGGCGTCACTCGAGTGCGCAGGCGCCTGGCGGT
TACCGGTCTCGCCATGGAGCGGAAAGTGCTCGCGCTCCAGGCCCGAAAGAAAAGGACCAAGGCC
AAGAAGGACAAAGCCCAAAGGAAGCCTGAAACCCAGCACCGAGGCTCTGCACCCCACTCCGAGA
GCGACATCCCCGAGCAGGAGGAGGAGATTCTGGGGTCTGATGATGATGAACAGGAAGACCCTAA
CGACTACTGTAAAGGAGGTTATCATCTTGTGAAAATTGGAGATCTATTTAACGGGCGATACCAT
GTGATTCGAAAATTAGGCTGGGGACACTTTTCCACAGTATGGTTATCATGGGATATTCAGGGAA
AGAAGTTTGTAGCAATGAAAGTAGTTAAAAGTGCCGAACATTACACAGAGACAGCACTGGATGA
GATCCGGCTCCTGAAATCGGTTCGCAATTCAGACCCGAATGATCCAAATGGAGAAATGGTCGTT
CAACTACTAGATGACTTTAAAATATCAGGCGTTAATGGAACACATATCTGCATGGTGTTTGAAG
TTTTAGGACATCATCTACTCAAGTGGATCATCAAGTCCAACTATCAGGGGCTTCCGCTGCCTTG
TGTCAAAAAAATTATTCAGCAAGTGCTCCAGGGTCTGGATTACTTACACACCAAGTGCCGGATC
ATCCACACTGACATCAAGCCGGAAAACATCCTGTTGTCCGTGAACGAGCAGTACATTCGGAGGC
TGGCTGCAGAGGCCACAGAGTGGCAACGGTCTGGAGCTCCCCCACCATCGGGGTCTGCAGTCAG
CACTGCTCCACAGCCTAAGCCAGCTGACAAAATGTCAAAGAATAAGAAGAAGAAATTGAAGAAG
AAGCAGAAGCGCCAGGCAGAATTACTAGAGAAGCGAATGCAGGAAATTGAGGAAATGGAGAAAG
AGTCGGGCCCTGGGCAAAAAAGACCTAACAAGCAAGAAGAATCAGAGAGTCCTGTTGAAAGACC
CTTGACAGAGAACCCACCTAATAAAATGACCCAAGAGAAACTTGAAGAGTCGAGTTCCATTGGC
CAGGATCAGACACTCACGGAGCATGGTGGAGAGGGTGGTGCGCCAGAAATTAATTGCAATGGAG
TGATTGGAATCGTTAATTACACTGCAAACAGTAACAATGAAACCTTGAGGCTTAAAGAGGACCT
ACATAATGCCAATGACTGTGATGGCCGCACTCTGAAGCAGGAACCTAGCTTCCTAAGCTCTCCA
AATGGAGACAGTAGTCCGTCTCCAGAAACAGACTCTTGCACACCTTCGGGCTCGGAGGTGCCCG
AGACCATGGCGTGCCAGGCCTCTGTAGAGCGGTCACTCACCCTCACCCAACAGGACATCACCCA
CCTGCAGGAGCGCATCCGGGCACATACGCCTTCTGGGGATGAGCAGGAGCGGGAACACAATGGA
GCGCTGGACAGCAAAGGAAAATTCTCTGCTGGAAATTTTCTTATTAATCCCCTGGAGCCAAAAA
ATGCAGAAAAGCTCAAAGTGAAGATTGCTGATCTTGGGAATGCCTGCTGGGTGCACAAGCATTT
CACCGAAGACATCCAGACCCGGCAGTACCGGTCTTTGGAGGTCCTGATAGGATCTGGCTACAAC
ACCCCTGCTGACATCTGGAGCACAGCATGCATGGCCTTTGAACTAGCCACAGGGGACTATCTGT
TTGAGCCTCATTCGGGGGAGGATTACACGCGAGATGAAGACCACATCGCCCTGATCATAGAGCT
CCTGGGGAAGGTGCCTCGCAAGCTCATTGTAGCAGGGAAATACTCCAAGGAATTTTTCACCAAA
AAAGGTGACCTGAAACACATCACCAAGTTGAAGCCTTGGGGTCTTCTGGAGGTTCTGGTGGAGA
AGTATGAGTGGCCTCAGGAGGAGGCTGCTGGCTTCACAGATTTCCTGCTGCCCATGTTGGAGCT
CATGCCTGAGAAGAGAGCCACTGCCGCTGAGTGTCTCCGGCATCCTTGGCTGAACTCCTAAGCC
AGCCCTGCCCGCCCGCCACTGCAGCAGGCTCATCAGACTGACCCTCCCTCCGGCCCTCCCCTCT
GAGGCTTCCCTCTCTTTTTTCCAGGGCAAAGCTCTTTCTTTCAAGGGTTTCTATTTTTTTTAAT
CCAACATGTTCATTTGGGTTTGCTTCCTTGATCCTGTGGGAATCCCACAGCCATTGGGCATCCT
AGGTGAATTTGGCCTTGGTTGGGCTCTGCCAAAGACTAAAAGTGTGAACAGCCTCAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAA

hide sequence

RefSeq Acc Id:

XM_039098820 ⟹ XP_038954748

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	20	6,645,809 - 6,682,159 (-)	NCBI

RefSeq Acc Id:

XM_039098821 ⟹ XP_038954749

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	20	6,645,809 - 6,682,448 (-)	NCBI

Protein Sequences


Protein RefSeqs	NP_001020897	(Get FASTA)	NCBI Sequence Viewer
	XP_038954748	(Get FASTA)	NCBI Sequence Viewer
	XP_038954749	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAH99089	(Get FASTA)	NCBI Sequence Viewer
	EDL96931	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000000612
	ENSRNOP00000000612.8
	ENSRNOP00000075811
	ENSRNOP00000075811.2
	ENSRNOP00000076564
	ENSRNOP00000076564.1
	ENSRNOP00000092552.1
	ENSRNOP00000096078.1

RefSeq Acc Id:

NP_001020897 ⟸ NM_001025726

- UniProtKB:

Q4KLN3 (UniProtKB/TrEMBL), E9PTN4 (UniProtKB/TrEMBL), A0A9K3Y6Q8 (UniProtKB/TrEMBL), A0A0U1RRU0 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MERKVLALQARKKRTKAKKDKAQRKPETQHRGSAPHSESDIPEQEEEILGSDDDEQEDPNDYCK
GGYHLVKIGDLFNGRYHVIRKLGWGHFSTVWLSWDIQGKKFVAMKVVKSAEHYTETALDEIRLL
KSVRNSDPNDPNGEMVVQLLDDFKISGVNGTHICMVFEVLGHHLLKWIIKSNYQGLPLPCVKKI
IQQVLQGLDYLHTKCRIIHTDIKPENILLSVNEQYIRRLAAEATEWQRSGAPPPSGSAVSTAPQ
PKPADKMSKNKKKKLKKKQKRQAELLEKRMQEIEEMEKESGPGQKRPNKQEESESPVERPLTEN
PPNKMTQEKLEESSSIGQDQTLTEHGGEGGAPEINCNGVIGIVNYTANSNNETLRLKEDLHNAN
DCDGRTLKQEPSFLSSPNGDSSPSPETDSCTPSGSEVPETMACQASVERSLTLTQQDITHLQER
IRAHTPSGDEQEREHNGALDSKGKFSAGNFLINPLEPKNAEKLKVKIADLGNACWVHKHFTEDI
QTRQYRSLEVLIGSGYNTPADIWSTACMAFELATGDYLFEPHSGEDYTRDEDHIALIIELLGKV
PRKLIVAGKYSKEFFTKKGDLKHITKLKPWGLLEVLVEKYEWPQEEAAGFTDFLLPMLELMPEK
RATAAECLRHPWLNS

hide sequence

RefSeq Acc Id:

ENSRNOP00000075811 ⟸ ENSRNOT00000092641

RefSeq Acc Id:

ENSRNOP00000000612 ⟸ ENSRNOT00000000612

RefSeq Acc Id:	XP_038954749 ⟸ XM_039098821
- Peptide Label:	isoform X2
- UniProtKB:	A0A0U1RRU0 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038954748 ⟸ XM_039098820
- Peptide Label:	isoform X1
- UniProtKB:	A0A8I5XV63 (UniProtKB/TrEMBL), A0A0U1RRU0 (UniProtKB/TrEMBL)

RefSeq Acc Id:

ENSRNOP00000076564 ⟸ ENSRNOT00000105949

RefSeq Acc Id:

ENSRNOP00000092552 ⟸ ENSRNOT00000100033

Protein Domains

Protein kinase

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-A0A0U1RRU0-F1-model_v2	AlphaFold	A0A0U1RRU0	1-655	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13701432

Promoter ID:

EPDNEW_R11955

Type:

initiation region

Name:

Srpk1_1

Description:

SRSF protein kinase 1

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	20	5,865,819 - 5,865,879	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1308272	AgrOrtholog
BioCyc Gene	G2FUF-4414	BioCyc
Ensembl Genes	ENSRNOG00000000511	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000000612	ENTREZGENE
	ENSRNOT00000000612.8	UniProtKB/TrEMBL
	ENSRNOT00000092514.2	UniProtKB/TrEMBL
	ENSRNOT00000092641	ENTREZGENE
	ENSRNOT00000092641.2	UniProtKB/TrEMBL
	ENSRNOT00000100033.1	UniProtKB/TrEMBL
	ENSRNOT00000105949	ENTREZGENE
	ENSRNOT00000105949.1	UniProtKB/TrEMBL
Gene3D-CATH	Transferase(Phosphotransferase) domain 1	UniProtKB/TrEMBL
IMAGE_CLONE	IMAGE:7456350	IMAGE-MGC_LOAD
InterPro	Kinase-like_dom	UniProtKB/TrEMBL
	Prot_kinase_cat_dom	UniProtKB/TrEMBL
	Protein_kinase_ATP_BS	UniProtKB/TrEMBL
	Ser/Thr_prot_kinase_AS	UniProtKB/TrEMBL
KEGG Report	rno:361811	UniProtKB/TrEMBL
MGC_CLONE	MGC:116186	IMAGE-MGC_LOAD
NCBI Gene	361811	ENTREZGENE
PANTHER	PROTEIN KINASE DOMAIN-CONTAINING PROTEIN-RELATED	UniProtKB/TrEMBL
	SRSF PROTEIN KINASE 1	UniProtKB/TrEMBL
Pfam	Pkinase	UniProtKB/TrEMBL
PhenoGen	Srpk1	PhenoGen
PROSITE	PROTEIN_KINASE_ATP	UniProtKB/TrEMBL
	PROTEIN_KINASE_DOM	UniProtKB/TrEMBL
	PROTEIN_KINASE_ST	UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000000511	RatGTEx
SMART	S_TKc	UniProtKB/TrEMBL
Superfamily-SCOP	Kinase_like	UniProtKB/TrEMBL
UniProt	A0A0U1RRU0	ENTREZGENE, UniProtKB/TrEMBL
	A0A8I5XV63	ENTREZGENE, UniProtKB/TrEMBL
	A0A8I6AI43_RAT	UniProtKB/TrEMBL
	A0A8I6AQC6_RAT	UniProtKB/TrEMBL
	A0A9K3Y6Q8	ENTREZGENE, UniProtKB/TrEMBL
	E9PTN4	ENTREZGENE
	Q4KLN3	ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary	E9PTN4	UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2011-08-01	Srpk1	SRSF protein kinase 1	Srpk1	SFRS protein kinase 1	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2011-07-22	Srpk1	SFRS protein kinase 1	Srpk1	Srsf protein kinase 1	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2011-07-13	Srpk1	Srsf protein kinase 1	Srpk1	SFRS protein kinase 1	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-10-23	Srpk1	SFRS protein kinase 1	Srpk1	serine/arginine-rich protein specific kinase 1	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2005-12-06	Srpk1	serine/arginine-rich protein specific kinase 1	Srpk1_predicted	serine/arginine-rich protein specific kinase 1 (predicted)	Symbol and Name updated	1559027	APPROVED
2005-01-12	Srpk1_predicted	serine/arginine-rich protein specific kinase 1 (predicted)			Symbol and Name status set to approved	70820	APPROVED

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InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

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MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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