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Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Object Symbol | Species | Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | Srpk1 | Rat | (+)-schisandrin B | multiple interactions | EXP | | 6480464 | schizandrin B inhibits the reaction [Carbon Tetrachloride results in increased expression of SRPK1 mRNA] | CTD | PMID:31150632 | Srpk1 | Rat | 1,2-dimethylhydrazine | increases expression | ISO | Srpk1 (Mus musculus) | 6480464 | 1 and 2-Dimethylhydrazine results in increased expression of SRPK1 mRNA | CTD | PMID:22206623 | Srpk1 | Rat | 1,2-dimethylhydrazine | multiple interactions | ISO | Srpk1 (Mus musculus) | 6480464 | Folic Acid inhibits the reaction [1 and 2-Dimethylhydrazine results in increased expression of SRPK1 mRNA] | CTD | PMID:22206623 | Srpk1 | Rat | 17beta-estradiol | multiple interactions | ISO | SRPK1 (Homo sapiens) | 6480464 | [Estradiol co-treated with Norethindrone Acetate] results in increased expression of SRPK1 mRNA | CTD | PMID:22217510 | Srpk1 | Rat | 17beta-estradiol | increases expression | ISO | SRPK1 (Homo sapiens) | 6480464 | Estradiol results in increased expression of SRPK1 mRNA | CTD | PMID:31614463 | Srpk1 | Rat | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | ISO | Srpk1 (Mus musculus) | 6480464 | Tetrachlorodibenzodioxin results in increased expression of SRPK1 mRNA | CTD | PMID:19770486 | Srpk1 | Rat | 2,3,7,8-tetrachlorodibenzodioxine | multiple interactions | ISO | Srpk1 (Mus musculus) | 6480464 | [TIPARP gene mutant form results in increased susceptibility to Tetrachlorodibenzodioxin] which results in increased expression of SRPK1 mRNA | CTD | PMID:25975270 | Srpk1 | Rat | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | ISO | Srpk1 (Mus musculus) | 6480464 | Tetrachlorodibenzodioxin affects the expression of SRPK1 mRNA | CTD | PMID:21570461 | Srpk1 | Rat | 2,4,6-tribromophenol | decreases expression | ISO | SRPK1 (Homo sapiens) | 6480464 | 2 more ... | CTD | PMID:31675489 | Srpk1 | Rat | 2-hydroxypropanoic acid | decreases expression | ISO | SRPK1 (Homo sapiens) | 6480464 | Lactic Acid results in decreased expression of SRPK1 mRNA | CTD | PMID:30851411 | Srpk1 | Rat | 2-methylcholine | affects expression | ISO | SRPK1 (Homo sapiens) | 6480464 | beta-methylcholine affects the expression of SRPK1 mRNA | CTD | PMID:21179406 | Srpk1 | Rat | 3,4-methylenedioxymethamphetamine | increases expression | ISO | Srpk1 (Mus musculus) | 6480464 | N-Methyl-3 and 4-methylenedioxyamphetamine results in increased expression of SRPK1 mRNA | CTD | PMID:20188158 | Srpk1 | Rat | acrolein | multiple interactions | ISO | SRPK1 (Homo sapiens) | 6480464 | [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone] results in decreased expression of and results in increased oxidation of SRPK1 mRNA and [Air Pollutants results in increased abundance of [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone]] which results in decreased expression of and results in increased oxidation of SRPK1 mRNA | CTD | PMID:32699268 | Srpk1 | Rat | acrylamide | increases expression | EXP | | 6480464 | Acrylamide results in increased expression of SRPK1 mRNA | CTD | PMID:28959563 | Srpk1 | Rat | aflatoxin B1 | increases expression | ISO | Srpk1 (Mus musculus) | 6480464 | Aflatoxin B1 results in increased expression of SRPK1 mRNA | CTD | PMID:19770486 | Srpk1 | Rat | all-trans-retinoic acid | decreases expression | ISO | SRPK1 (Homo sapiens) | 6480464 | Tretinoin results in decreased expression of SRPK1 mRNA | CTD | PMID:12875902 | Srpk1 | Rat | alpha-pinene | multiple interactions | ISO | SRPK1 (Homo sapiens) | 6480464 | [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone] results in decreased expression of and results in increased oxidation of SRPK1 mRNA and [Air Pollutants results in increased abundance of [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone]] which results in decreased expression of and results in increased oxidation of SRPK1 mRNA | CTD | PMID:32699268 | Srpk1 | Rat | arsenite(3-) | multiple interactions | ISO | SRPK1 (Homo sapiens) | 6480464 | arsenite inhibits the reaction [G3BP1 protein binds to SRPK1 protein] | CTD | PMID:32406909 | Srpk1 | Rat | benzo[a]pyrene | decreases expression | EXP | | 6480464 | Benzo(a)pyrene results in decreased expression of SRPK1 mRNA | CTD | PMID:21839799 | Srpk1 | Rat | benzo[a]pyrene | multiple interactions | ISO | SRPK1 (Homo sapiens) | 6480464 | [Soot co-treated with Benzo(a)pyrene] results in increased expression of SRPK1 protein modified form | CTD | PMID:24464499 | Srpk1 | Rat | benzo[a]pyrene diol epoxide I | decreases expression | ISO | SRPK1 (Homo sapiens) | 6480464 | 7 more ... | CTD | PMID:19150397 and PMID:26238291 | Srpk1 | Rat | bis(2-ethylhexyl) phthalate | decreases expression | ISO | Srpk1 (Mus musculus) | 6480464 | Diethylhexyl Phthalate results in decreased expression of SRPK1 mRNA | CTD | PMID:33754040 | Srpk1 | Rat | bisphenol A | increases expression | EXP | | 6480464 | bisphenol A results in increased expression of SRPK1 mRNA | CTD | PMID:25181051 | Srpk1 | Rat | bisphenol A | decreases expression | ISO | SRPK1 (Homo sapiens) | 6480464 | bisphenol A results in decreased expression of SRPK1 mRNA and bisphenol A results in decreased expression of SRPK1 protein | CTD | PMID:29275510 and PMID:37567409 | Srpk1 | Rat | bisphenol A | decreases expression | EXP | | 6480464 | bisphenol A results in decreased expression of SRPK1 mRNA | CTD | PMID:30816183 more ... | Srpk1 | Rat | Bisphenol A diglycidyl ether | affects splicing | ISO | Srpk1 (Mus musculus) | 6480464 | bisphenol A diglycidyl ether affects the splicing of SRPK1 mRNA | CTD | PMID:36464114 | Srpk1 | Rat | bisphenol AF | affects splicing | ISO | Srpk1 (Mus musculus) | 6480464 | bisphenol AF affects the splicing of SRPK1 mRNA | CTD | PMID:36464114 | Srpk1 | Rat | butyric acid | affects localization | ISO | SRPK1 (Homo sapiens) | 6480464 | Butyric Acid affects the localization of SRPK1 protein | CTD | PMID:21555914 | Srpk1 | Rat | C60 fullerene | increases expression | EXP | | 6480464 | fullerene C60 results in increased expression of SRPK1 mRNA | CTD | PMID:19167457 | Srpk1 | Rat | cadmium atom | increases expression | ISO | SRPK1 (Homo sapiens) | 6480464 | Cadmium results in increased expression of SRPK1 mRNA | CTD | PMID:23369406 | Srpk1 | Rat | cadmium atom | multiple interactions | ISO | Srpk1 (Mus musculus) | 6480464 | [Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of SRPK1 mRNA | CTD | PMID:37325564 | Srpk1 | Rat | cadmium dichloride | decreases methylation | EXP | | 6480464 | Cadmium Chloride results in decreased methylation of SRPK1 promoter | CTD | PMID:22457795 | Srpk1 | Rat | cadmium dichloride | multiple interactions | ISO | Srpk1 (Mus musculus) | 6480464 | [Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of SRPK1 mRNA | CTD | PMID:37325564 | Srpk1 | Rat | cadmium dichloride | increases expression | ISO | SRPK1 (Homo sapiens) | 6480464 | Cadmium Chloride results in increased expression of SRPK1 mRNA | CTD | PMID:26472689 | Srpk1 | Rat | caffeine | decreases phosphorylation | ISO | SRPK1 (Homo sapiens) | 6480464 | Caffeine results in decreased phosphorylation of SRPK1 protein | CTD | PMID:35688186 | Srpk1 | Rat | calcitriol | decreases expression | ISO | SRPK1 (Homo sapiens) | 6480464 | Calcitriol results in decreased expression of SRPK1 mRNA | CTD | PMID:12875902 | Srpk1 | Rat | CGP 52608 | multiple interactions | ISO | SRPK1 (Homo sapiens) | 6480464 | CGP 52608 promotes the reaction [RORA protein binds to SRPK1 gene] | CTD | PMID:28238834 | Srpk1 | Rat | choline | multiple interactions | ISO | Srpk1 (Mus musculus) | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of SRPK1 gene | CTD | PMID:20938992 | Srpk1 | Rat | cisplatin | affects localization | ISO | SRPK1 (Homo sapiens) | 6480464 | Cisplatin affects the localization of SRPK1 protein | CTD | PMID:21157427 | Srpk1 | Rat | copper atom | multiple interactions | ISO | SRPK1 (Homo sapiens) | 6480464 | [Thiosemicarbazones binds to Copper] which results in increased expression of SRPK1 protein | CTD | PMID:20931265 | Srpk1 | Rat | copper(0) | multiple interactions | ISO | SRPK1 (Homo sapiens) | 6480464 | [Thiosemicarbazones binds to Copper] which results in increased expression of SRPK1 protein | CTD | PMID:20931265 | Srpk1 | Rat | crocidolite asbestos | decreases expression | ISO | Srpk1 (Mus musculus) | 6480464 | Asbestos and Crocidolite results in decreased expression of SRPK1 mRNA | CTD | PMID:29279043 | Srpk1 | Rat | decabromodiphenyl ether | increases expression | EXP | | 6480464 | decabromobiphenyl ether results in increased expression of SRPK1 mRNA | CTD | PMID:23640034 | Srpk1 | Rat | Dibutyl phosphate | affects expression | ISO | SRPK1 (Homo sapiens) | 6480464 | di-n-butylphosphoric acid affects the expression of SRPK1 mRNA | CTD | PMID:37042841 | Srpk1 | Rat | Diisodecyl phthalate | increases expression | ISO | Srpk1 (Mus musculus) | 6480464 | diisodecyl phthalate results in increased expression of SRPK1 mRNA | CTD | PMID:25270620 | Srpk1 | Rat | elemental selenium | multiple interactions | ISO | SRPK1 (Homo sapiens) | 6480464 | [Selenium co-treated with Vitamin E] results in decreased expression of SRPK1 mRNA | CTD | PMID:19244175 | Srpk1 | Rat | elemental selenium | decreases expression | ISO | SRPK1 (Homo sapiens) | 6480464 | Selenium results in decreased expression of SRPK1 mRNA | CTD | PMID:19244175 | Srpk1 | Rat | enzyme inhibitor | multiple interactions | ISO | SRPK1 (Homo sapiens) | 6480464 | [Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of SRPK1 protein | CTD | PMID:23301498 | Srpk1 | Rat | fenthion | decreases expression | ISO | Srpk1 (Mus musculus) | 6480464 | Fenthion results in decreased expression of SRPK1 mRNA | CTD | PMID:34813904 | Srpk1 | Rat | folic acid | multiple interactions | ISO | Srpk1 (Mus musculus) | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of SRPK1 gene more ... | CTD | PMID:20938992 and PMID:22206623 | Srpk1 | Rat | folic acid | decreases expression | ISO | Srpk1 (Mus musculus) | 6480464 | Folic Acid results in decreased expression of SRPK1 mRNA | CTD | PMID:25629700 | Srpk1 | Rat | formaldehyde | decreases expression | ISO | SRPK1 (Homo sapiens) | 6480464 | Formaldehyde results in decreased expression of SRPK1 mRNA | CTD | PMID:23649840 | Srpk1 | Rat | FR900359 | affects phosphorylation | ISO | SRPK1 (Homo sapiens) | 6480464 | FR900359 affects the phosphorylation of SRPK1 protein | CTD | PMID:37730182 | Srpk1 | Rat | furan | increases methylation | EXP | | 6480464 | furan results in increased methylation of SRPK1 gene | CTD | PMID:22079235 | Srpk1 | Rat | gentamycin | decreases expression | EXP | | 6480464 | Gentamicins results in decreased expression of SRPK1 mRNA | CTD | PMID:33387578 | Srpk1 | Rat | isoflurane | decreases methylation | ISO | Srpk1 (Mus musculus) | 6480464 | Isoflurane results in decreased methylation of SRPK1 mRNA | CTD | PMID:35249202 | Srpk1 | Rat | ivermectin | decreases expression | ISO | SRPK1 (Homo sapiens) | 6480464 | Ivermectin results in decreased expression of SRPK1 protein | CTD | PMID:32959892 | Srpk1 | Rat | ketamine | decreases expression | EXP | | 6480464 | Ketamine results in decreased expression of SRPK1 mRNA | CTD | PMID:20080153 | Srpk1 | Rat | L-methionine | multiple interactions | ISO | Srpk1 (Mus musculus) | 6480464 | [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of SRPK1 gene | CTD | PMID:20938992 | Srpk1 | Rat | lead(0) | affects expression | ISO | SRPK1 (Homo sapiens) | 6480464 | Lead affects the expression of SRPK1 mRNA | CTD | PMID:28903495 | Srpk1 | Rat | menadione | affects expression | ISO | SRPK1 (Homo sapiens) | 6480464 | Vitamin K 3 affects the expression of SRPK1 mRNA | CTD | PMID:20044591 | Srpk1 | Rat | methidathion | decreases expression | ISO | Srpk1 (Mus musculus) | 6480464 | methidathion results in decreased expression of SRPK1 mRNA | CTD | PMID:34813904 | Srpk1 | Rat | N-nitrosodiethylamine | increases expression | EXP | | 6480464 | Diethylnitrosamine results in increased expression of SRPK1 mRNA | CTD | PMID:19041683 | Srpk1 | Rat | oxaliplatin | increases expression | ISO | SRPK1 (Homo sapiens) | 6480464 | oxaliplatin results in increased expression of SRPK1 mRNA | CTD | PMID:16773204 | Srpk1 | Rat | oxaliplatin | affects response to substance | ISO | SRPK1 (Homo sapiens) | 6480464 | SRPK1 protein affects the susceptibility to oxaliplatin | CTD | PMID:16773204 | Srpk1 | Rat | ozone | multiple interactions | ISO | SRPK1 (Homo sapiens) | 6480464 | [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone] results in decreased expression of and results in increased oxidation of SRPK1 mRNA more ... | CTD | PMID:32699268 | Srpk1 | Rat | paraquat | multiple interactions | ISO | SRPK1 (Homo sapiens) | 6480464 | SRPK1 protein affects the reaction [Paraquat results in increased phosphorylation of SRSF3 protein] more ... | CTD | PMID:23613995 | Srpk1 | Rat | protein kinase inhibitor | decreases activity | ISO | SRPK1 (Homo sapiens) | 6480464 | Protein Kinase Inhibitors results in decreased activity of SRPK1 protein | CTD | PMID:35568131 | Srpk1 | Rat | protein kinase inhibitor | multiple interactions | ISO | SRPK1 (Homo sapiens) | 6480464 | [Protein Kinase Inhibitors results in decreased activity of SRPK1 protein] which results in decreased expression of SRSF1 protein modified form more ... | CTD | PMID:35568131 | Srpk1 | Rat | rac-lactic acid | decreases expression | ISO | SRPK1 (Homo sapiens) | 6480464 | Lactic Acid results in decreased expression of SRPK1 mRNA | CTD | PMID:30851411 | Srpk1 | Rat | resveratrol | decreases expression | ISO | SRPK1 (Homo sapiens) | 6480464 | resveratrol results in decreased expression of SRPK1 protein | CTD | PMID:18089832 | Srpk1 | Rat | selenium atom | multiple interactions | ISO | SRPK1 (Homo sapiens) | 6480464 | [Selenium co-treated with Vitamin E] results in decreased expression of SRPK1 mRNA | CTD | PMID:19244175 | Srpk1 | Rat | selenium atom | decreases expression | ISO | SRPK1 (Homo sapiens) | 6480464 | Selenium results in decreased expression of SRPK1 mRNA | CTD | PMID:19244175 | Srpk1 | Rat | sevoflurane | decreases methylation | ISO | Srpk1 (Mus musculus) | 6480464 | Sevoflurane results in decreased methylation of SRPK1 mRNA | CTD | PMID:35249202 | Srpk1 | Rat | sodium arsenite | decreases expression | ISO | SRPK1 (Homo sapiens) | 6480464 | sodium arsenite results in decreased expression of SRPK1 mRNA and sodium arsenite results in decreased expression of SRPK1 protein | CTD | PMID:30528433 and PMID:38568856 | Srpk1 | Rat | tetrachloromethane | multiple interactions | EXP | | 6480464 | schizandrin B inhibits the reaction [Carbon Tetrachloride results in increased expression of SRPK1 mRNA] | CTD | PMID:31150632 | Srpk1 | Rat | tetrachloromethane | increases expression | ISO | Srpk1 (Mus musculus) | 6480464 | Carbon Tetrachloride results in increased expression of SRPK1 mRNA | CTD | PMID:31919559 | Srpk1 | Rat | tetrachloromethane | increases expression | EXP | | 6480464 | Carbon Tetrachloride results in increased expression of SRPK1 mRNA | CTD | PMID:31150632 | Srpk1 | Rat | thioacetamide | increases expression | EXP | | 6480464 | Thioacetamide results in increased expression of SRPK1 mRNA | CTD | PMID:23411599 | Srpk1 | Rat | titanium dioxide | decreases methylation | ISO | Srpk1 (Mus musculus) | 6480464 | titanium dioxide results in decreased methylation of SRPK1 gene | CTD | PMID:35295148 | Srpk1 | Rat | triphenyl phosphate | affects expression | ISO | SRPK1 (Homo sapiens) | 6480464 | triphenyl phosphate affects the expression of SRPK1 mRNA | CTD | PMID:37042841 | Srpk1 | Rat | vitamin E | decreases expression | ISO | SRPK1 (Homo sapiens) | 6480464 | Vitamin E results in decreased expression of SRPK1 mRNA | CTD | PMID:19244175 | Srpk1 | Rat | vitamin E | multiple interactions | ISO | SRPK1 (Homo sapiens) | 6480464 | [Selenium co-treated with Vitamin E] results in decreased expression of SRPK1 mRNA | CTD | PMID:19244175 | |