Gene: Wdr46 (WD repeat domain 46) Rattus norvegicus
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Symbol:
Wdr46
Name:
WD repeat domain 46
Description:
Predicted to be involved in maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA). Predicted to localize to the nucleolus and small-subunit processome. Orthologous to human WDR46 (WD repeat domain 46); INTERACTS WITH (+)-schisandrin B; 2,4-dinitrotoluene; 4-amino-2,6-dinitrotoluene.
Type:
protein-coding
RefSeq Status:
VALIDATED
Also known as:
Bing4; MGC94931; WD repeat-containing protein 46
Orthologs:
Species
Gene symbol and name
Data Source
Assertion derived from
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Orthologs 1
Homo sapiens (human):
WDR46 (WD repeat domain 46) HGNC
Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Mus musculus (house mouse):
Wdr46 (WD repeat domain 46) HGNC
Treefam, OrthoMCL, NCBI, OMA, HomoloGene, Inparanoid, Panther, PhylomeDB, OrthoDB, Ensembl
Chinchilla lanigera (long-tailed chinchilla):
Wdr46 (WD repeat domain 46) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):
WDR46 (WD repeat domain 46) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Canis lupus familiaris (dog):
WDR46 (WD repeat domain 46) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):
Wdr46 (WD repeat domain 46) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Sus scrofa (pig):
WDR46 (WD repeat domain 46) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Alliance orthologs 3
Homo sapiens (human):
WDR46 (WD repeat domain 46)
Alliance
DIOPT (HGNC, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB, TreeFam)
Mus musculus (house mouse):
Wdr46 (WD repeat domain 46)
Alliance
DIOPT (Ensembl Compara, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB, TreeFam)
Danio rerio (zebrafish):
wdr46 (WD repeat domain 46)
Alliance
DIOPT (Ensembl Compara, Hieranoid, OMA, OrthoFinder, PANTHER, PhylomeDB)
Drosophila melanogaster (fruit fly):
CG2260
Alliance
DIOPT (Ensembl Compara, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB, TreeFam)
Saccharomyces cerevisiae (baker's yeast):
UTP7
Alliance
DIOPT (Ensembl Compara, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB, TreeFam)
Caenorhabditis elegans (roundworm):
wdr-46
Alliance
DIOPT (Ensembl Compara, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB)
Latest Assembly:
Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl Rnor_6.0 20 5,447,860 - 5,455,632 (-) NCBI Rnor6.0 Rnor_6.0 rn6 Rnor6.0 Rnor_6.0 Ensembl 20 5,447,860 - 5,455,632 (-) Ensembl Rnor_5.0 20 7,506,472 - 7,514,244 (-) NCBI Rnor5.0 Rnor_5.0 rn5 Rnor5.0 RGSC_v3.4 20 5,089,611 - 5,097,383 (-) NCBI RGSC3.4 rn4 RGSC3.4 RGSC_v3.1 20 5,089,839 - 5,097,610 (-) NCBI Celera 20 6,522,088 - 6,529,834 (-) NCBI Celera Cytogenetic Map 20 p12 NCBI
JBrowse:
View Region in Genome Browser (JBrowse)
Model
Imported Annotations - CTD
Disease Progression ISO RGD:1353590 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:21364753 Stomach Neoplasms ISO RGD:1353590 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:21364753
Gene-Chemical Interaction Annotations
(+)-schisandrin B multiple interactions EXP 6480464 schizandrin B inhibits the reaction [Carbon Tetrachloride results in increased expression of WDR46 mRNA] CTD PMID:31150632 17alpha-ethynylestradiol increases expression ISO RGD:1551804 6480464 Ethinyl Estradiol results in increased expression of WDR46 mRNA CTD PMID:17942748 17alpha-ethynylestradiol multiple interactions ISO RGD:1551804 6480464 [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of WDR46 mRNA CTD PMID:17942748 17alpha-ethynylestradiol affects expression ISO RGD:1551804 6480464 Ethinyl Estradiol affects the expression of WDR46 mRNA CTD PMID:17555576 2,3,7,8-tetrachlorodibenzodioxine multiple interactions ISO RGD:1551804 6480464 [Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of WDR46 mRNA CTD PMID:17942748 2,3,7,8-tetrachlorodibenzodioxine affects expression ISO RGD:1551804 6480464 Tetrachlorodibenzodioxin affects the expression of WDR46 mRNA CTD PMID:21570461 2,3,7,8-tetrachlorodibenzodioxine increases expression ISO RGD:1551804 6480464 Tetrachlorodibenzodioxin results in increased expression of WDR46 mRNA CTD PMID:17942748 2,4-dinitrotoluene affects expression EXP 6480464 2, 4-dinitrotoluene affects the expression of WDR46 mRNA CTD PMID:21346803 2-hydroxypropanoic acid decreases expression ISO RGD:1353590 6480464 Lactic Acid results in decreased expression of WDR46 mRNA CTD PMID:30851411 3-isobutyl-1-methyl-7H-xanthine multiple interactions ISO RGD:1353590 6480464 [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of WDR46 mRNA CTD PMID:28628672 4-amino-2,6-dinitrotoluene affects expression EXP 6480464 4-amino-2, 6-dinitrotoluene affects the expression of WDR46 mRNA CTD PMID:21346803 ammonium chloride affects expression EXP 6480464 Ammonium Chloride affects the expression of WDR46 mRNA CTD PMID:16483693 atrazine decreases expression ISO RGD:1353590 6480464 Atrazine results in decreased expression of WDR46 mRNA CTD PMID:22378314 benzalkonium chloride affects response to substance ISO RGD:1353590 6480464 WDR46 SNP affects the susceptibility to Benzalkonium Compounds CTD PMID:27258892 bisphenol A increases expression EXP 6480464 bisphenol A results in increased expression of WDR46 mRNA CTD PMID:25181051 bisphenol F multiple interactions ISO RGD:1353590 6480464 [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of WDR46 mRNA CTD PMID:28628672 cadmium atom decreases expression ISO RGD:1353590 6480464 Cadmium results in decreased expression of WDR46 mRNA CTD PMID:23369406 cadmium dichloride decreases methylation EXP 6480464 Cadmium Chloride results in decreased methylation of WDR46 promoter CTD PMID:22457795 carbon nanotube increases expression ISO RGD:1551804 6480464 Nanotubes, Carbon results in increased expression of WDR46 mRNA CTD PMID:25554681 cisplatin affects response to substance ISO RGD:1353590 6480464 WDR46 protein affects the susceptibility to Cisplatin CTD PMID:16217747 cisplatin decreases expression ISO RGD:1353590 6480464 Cisplatin results in decreased expression of WDR46 mRNA CTD PMID:27594783 clobetasol increases expression ISO RGD:1551804 6480464 Clobetasol results in increased expression of WDR46 mRNA CTD PMID:27462272 clofibric acid multiple interactions EXP 6480464 [Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of WDR46 mRNA CTD PMID:17602206 cyclosporin A increases expression ISO RGD:1353590 6480464 Cyclosporine results in increased expression of WDR46 mRNA CTD PMID:20106945 dexamethasone multiple interactions ISO RGD:1353590 6480464 [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of WDR46 mRNA CTD PMID:28628672 ethyl methanesulfonate decreases expression ISO RGD:1353590 6480464 Ethyl Methanesulfonate results in decreased expression of WDR46 mRNA CTD PMID:23649840 flusilazole affects expression ISO RGD:1551804 6480464 flusilazole affects the expression of WDR46 mRNA CTD PMID:21195148 flutamide increases expression EXP 6480464 Flutamide results in increased expression of WDR46 mRNA CTD PMID:24136188 flutamide decreases expression EXP 6480464 Flutamide results in decreased expression of WDR46 mRNA CTD PMID:24793618 furan increases methylation EXP 6480464 furan results in increased methylation of WDR46 gene CTD PMID:22079235 hexaconazole affects expression ISO RGD:1551804 6480464 hexaconazole affects the expression of WDR46 mRNA CTD PMID:21195148 hydralazine multiple interactions ISO RGD:1353590 6480464 [Hydralazine co-treated with Valproic Acid] results in increased expression of WDR46 mRNA CTD PMID:17183730 indometacin multiple interactions ISO RGD:1353590 6480464 [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of WDR46 mRNA CTD PMID:28628672 methyl methanesulfonate decreases expression ISO RGD:1353590 6480464 Methyl Methanesulfonate results in decreased expression of WDR46 mRNA CTD PMID:23649840 N-nitrosodiethylamine multiple interactions EXP 6480464 [Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of WDR46 mRNA CTD PMID:17602206 ochratoxin A decreases expression EXP 6480464 ochratoxin A results in decreased expression of WDR46 mRNA CTD PMID:22124623 paracetamol affects expression ISO RGD:1551804 6480464 Acetaminophen affects the expression of WDR46 mRNA CTD PMID:17562736 rac-lactic acid decreases expression ISO RGD:1353590 6480464 Lactic Acid results in decreased expression of WDR46 mRNA CTD PMID:30851411 rotenone increases expression EXP 6480464 Rotenone results in increased expression of WDR46 mRNA CTD PMID:28374803 sodium arsenate decreases expression ISO RGD:1551804 6480464 sodium arsenate results in decreased expression of WDR46 mRNA CTD PMID:30953684 tamoxifen affects expression ISO RGD:1551804 6480464 Tamoxifen affects the expression of WDR46 mRNA CTD PMID:17555576 testosterone enanthate affects expression ISO RGD:1353590 6480464 testosterone enanthate affects the expression of WDR46 mRNA CTD PMID:17440010 tetrachloromethane affects expression ISO RGD:1551804 6480464 Carbon Tetrachloride affects the expression of WDR46 mRNA CTD PMID:17484886 tetrachloromethane multiple interactions EXP 6480464 schizandrin B inhibits the reaction [Carbon Tetrachloride results in increased expression of WDR46 mRNA] CTD PMID:31150632 tetrachloromethane increases expression EXP 6480464 Carbon Tetrachloride results in increased expression of WDR46 mRNA CTD PMID:31150632 thioacetamide increases expression EXP 6480464 Thioacetamide results in increased expression of WDR46 mRNA CTD PMID:23411599 triadimefon affects expression ISO RGD:1551804 6480464 triadimefon affects the expression of WDR46 mRNA CTD PMID:21195148 urethane decreases expression ISO RGD:1353590 6480464 Urethane results in decreased expression of WDR46 mRNA CTD PMID:28818685 valproic acid increases methylation ISO RGD:1353590 6480464 Valproic Acid results in increased methylation of WDR46 gene CTD PMID:29154799 valproic acid affects expression ISO RGD:1353590 6480464 Valproic Acid affects the expression of WDR46 mRNA CTD PMID:25979313 valproic acid increases expression ISO RGD:1353590 6480464 Valproic Acid results in increased expression of WDR46 mRNA CTD PMID:23179753 valproic acid multiple interactions ISO RGD:1353590 6480464 [Hydralazine co-treated with Valproic Acid] results in increased expression of WDR46 mRNA CTD PMID:17183730 vinclozolin increases expression EXP 6480464 vinclozolin results in increased expression of WDR46 mRNA CTD PMID:22570695 , PMID:23869203 zinc atom decreases expression ISO RGD:1353590 6480464 Zinc results in decreased expression of WDR46 mRNA CTD PMID:15226459 zinc sulfate decreases expression ISO RGD:1353590 6480464 Zinc Sulfate results in decreased expression of WDR46 mRNA CTD PMID:15226459 zinc(0) decreases expression ISO RGD:1353590 6480464 Zinc results in decreased expression of WDR46 mRNA CTD PMID:15226459
Gene Ontology Annotations
1354642 Despr15 Despair related QTL 15 0.0027 locomotor behavior trait (VT:0001392) amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958) 20 1 24652101 Rat 1600382 Edcs3 Endometrial carcinoma susceptibility QTL3 3.5 0.003 uterus morphology trait (VT:0001120) percentage of study population developing endometrioid carcinoma during a period of time (CMO:0001759) 20 1 25653396 Rat 1641893 Alcrsp7 Alcohol response QTL 7 response to alcohol trait (VT:0010489) duration of loss of righting reflex (CMO:0002289) 20 1 26305996 Rat 2317851 Alcrsp22 Alcohol response QTL 22 3.2 0.05 response to alcohol trait (VT:0010489) duration of loss of righting reflex (CMO:0002289) 20 1 26305996 Rat 7387283 Uae44 Urinary albumin excretion QTL 44 0.1712 urine albumin amount (VT:0002871) urine albumin excretion rate (CMO:0000757) 20 1 27357423 Rat 9590275 Scort15 Serum corticosterone level QTL 15 3.48 0.001 blood corticosterone amount (VT:0005345) plasma corticosterone level (CMO:0001173) 20 1 28375393 Rat 9589155 Insul32 Insulin level QTL 32 6.38 0.001 blood insulin amount (VT:0001560) plasma insulin level (CMO:0000342) 20 1 28375393 Rat 9590109 Sffal8 Serum free fatty acids level QTL 8 5.32 0.01 blood free fatty acid amount (VT:0001553) plasma free fatty acids level (CMO:0000546) 20 1 28375393 Rat 7411650 Foco23 Food consumption QTL 23 20.7 0.001 eating behavior trait (VT:0001431) feed conversion ratio (CMO:0001312) 20 1 28375393 Rat 8694189 Bw153 Body weight QTL 153 3.13 0.001 body mass (VT:0001259) body weight gain (CMO:0000420) 20 1 28375393 Rat 6893685 Bw111 Body weight QTL 111 2.7 0.004 body mass (VT:0001259) body weight (CMO:0000012) 20 1 33300419 Rat 9590252 Scort12 Serum corticosterone level QTL 12 20.46 0.001 blood corticosterone amount (VT:0005345) plasma corticosterone level (CMO:0001173) 20 1 37550487 Rat 7411668 Foco32 Food consumption QTL 32 8 0.001 eating behavior trait (VT:0001431) feed conversion ratio (CMO:0001312) 20 1 37550487 Rat 2305926 Iddm37 Insulin dependent diabetes mellitus QTL 37 6 blood glucose amount (VT:0000188) plasma glucose level (CMO:0000042) 20 2018654 47018654 Rat 2306850 Pia40 Pristane induced arthritis QTL 40 0.0001 joint integrity trait (VT:0010548) joint inflammation composite score (CMO:0000919) 20 2018770 6567419 Rat 1641915 Colcr9 Colorectal carcinoma resistance QTL 9 2.97 0.0024 intestine integrity trait (VT:0010554) benign colorectal tumor number (CMO:0001795) 20 2999707 47999707 Rat 61472 Aia1 Adjuvant induced arthritis QTL 1 18 0.001 joint integrity trait (VT:0010548) joint inflammation composite score (CMO:0000919) 20 3151815 6896013 Rat 61448 Ciaa1 CIA Autoantibody QTL 1 30 0.001 blood autoantibody amount (VT:0003725) calculated serum anti-rat type 2 collagen autoantibody titer (CMO:0001281) 20 3151815 6896013 Rat 2317057 Aia27 Adjuvant induced arthritis QTL 27 2.83 joint integrity trait (VT:0010548) right rear ankle joint diameter (CMO:0002150) 20 3402111 27968216 Rat 7175096 Tcs1 T cell selection QTL 1 T cell selection expression 20 3910555 5533640 Rat 61474 Eae1 Experimental allergic encephalomyelitis QTL 1 3 nervous system integrity trait (VT:0010566) experimental autoimmune encephalomyelitis severity score (CMO:0001419) 20 4039113 5875448 Rat 1558640 Prcs2 Prostate cancer susceptibility QTL 2 3.3 prostate integrity trait (VT:0010571) percentage of study population developing ventral prostate tumorous lesions during a period of time (CMO:0000943) 20 4039113 18872273 Rat 4889857 Pur27 Proteinuria QTL 27 12.2 0.001 total urine protein amount (VT:0000032) urine total protein excretion rate (CMO:0000756) 20 4039113 18872273 Rat 1598816 Memor12 Memory QTL 12 2.4 exploratory behavior trait (VT:0010471) average horizontal distance in proximity to the target during voluntary locomotion in an experimental apparatus (CMO:0002674) 20 4108956 49108956 Rat 1300152 Bp195 Blood pressure QTL 195 3.46 arterial blood pressure trait (VT:2000000) systolic blood pressure (CMO:0000004) 20 4855468 9899946 Rat 1331772 Cdexp2 CD45RC expression in CD8 T cells QTL 2 5.7 CD8-positive T cell quantity (VT:0008077) blood CD45RChigh CD8 T cell count to CD45RClow CD8 T cell count ratio (CMO:0001990) 20 4855468 10800530 Rat 61432 Cia1 Collagen induced arthritis QTL 1 joint integrity trait (VT:0010548) joint inflammation composite score (CMO:0000919) 20 4855475 15050565 Rat
Predicted Target Of
Count of predictions: 57 Count of miRNA genes: 48 Interacting mature miRNAs: 55 Transcripts: ENSRNOT00000000552 Prediction methods: Miranda, Rnahybrid, Targetscan Result types: miRGate_prediction
Gene-Chemical Interaction Annotations
