Wdr46 (WD repeat domain 46) - Rat Genome Database

Name: Wdr46
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

Gene: Wdr46 (WD repeat domain 46) Chinchilla lanigera

Analyze

Symbol:

Wdr46

Name:

WD repeat domain 46

RGD ID:

8770172

Description:

INVOLVED IN ribosomal small subunit biogenesis (ortholog); ASSOCIATED WITH autosomal dominant intellectual developmental disorder 5 (ortholog); Disease Progression (ortholog); genetic disease (ortholog); FOUND IN nucleolus (ortholog); small-subunit processome (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

WD repeat-containing protein 46

RGD Orthologs

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	WDR46 (WD repeat domain 46)	NCBI	Ortholog
Mus musculus (house mouse):	Wdr46 (WD repeat domain 46)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus norvegicus (Norway rat):	Wdr46 (WD repeat domain 46)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	WDR46 (WD repeat domain 46)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	WDR46 (WD repeat domain 46)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Wdr46 (WD repeat domain 46)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	WDR46 (WD repeat domain 46)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	WDR46 (WD repeat domain 46)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Wdr46 (WD repeat domain 46)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline

Latest Assembly:

ChiLan1.0 - Chinchilla ChiLan1.0 Assembly

Position:

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955437	1,840,791 - 1,848,172 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955437	1,840,875 - 1,848,258 (-)	NCBI	ChiLan1.0	ChiLan1.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

autosomal dominant intellectual developmental disorder 5 (ISO)

Disease Progression (ISO)

genetic disease (ISO)

proteasome-associated autoinflammatory syndrome 1 (ISO)

Stomach Neoplasms (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

ribosomal small subunit biogenesis (ISO)

Cellular Component

nucleolus (ISO)

small-subunit processome (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Transitive Annotation Pipeline	Automated assignment of GO, PW and RDO ISO annotations across species

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

Wdr46
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955437	1,840,791 - 1,848,172 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955437	1,840,875 - 1,848,258 (-)	NCBI	ChiLan1.0	ChiLan1.0

WDR46
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	6	33,279,108 - 33,289,239 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	6	33,279,108 - 33,289,247 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	6	33,246,885 - 33,257,016 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	6	33,354,863 - 33,364,969 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	6	33,354,863 - 33,364,969	NCBI
Celera	6	34,801,238 - 34,811,662 (-)	NCBI		Celera
Cytogenetic Map	6	p21.32	NCBI
HuRef	6	32,988,537 - 32,998,938 (-)	NCBI		HuRef
CHM1_1	6	33,248,816 - 33,259,244 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	6	33,100,470 - 33,110,601 (-)	NCBI		T2T-CHM13v2.0

Wdr46
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	17	34,159,608 - 34,168,669 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	17	34,159,634 - 34,168,671 (+)	Ensembl		GRCm39 Ensembl
GRCm38	17	33,940,634 - 33,949,695 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	17	33,940,660 - 33,949,697 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	17	34,077,668 - 34,086,640 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	17	33,551,177 - 33,560,149 (+)	NCBI		MGSCv36	mm8
Celera	17	36,693,635 - 36,702,594 (+)	NCBI		Celera
Cytogenetic Map	17	B1	NCBI
cM Map	17	17.98	NCBI

Wdr46
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	20	4,939,721 - 4,947,619 (-)	NCBI		GRCr8
mRatBN7.2	20	4,937,845 - 4,945,796 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	20	4,937,847 - 4,946,535 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	20	5,661,367 - 5,669,100 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	20	5,023,112 - 5,030,845 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	20	5,503,899 - 5,511,638 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	20	5,447,860 - 5,455,632 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	20	5,447,860 - 5,455,632 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	20	7,506,472 - 7,514,244 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	20	5,089,611 - 5,097,383 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	20	5,089,839 - 5,097,610 (-)	NCBI
Celera	20	6,522,088 - 6,529,834 (-)	NCBI		Celera
Cytogenetic Map	20	p12	NCBI

WDR46
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	5	47,756,943 - 47,767,149 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	6	43,628,607 - 43,638,816 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	6	32,851,335 - 32,861,806 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	6	33,965,528 - 33,975,898 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	6	33,965,528 - 33,975,898 (-)	Ensembl	panpan1.1		panPan2

WDR46
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	12	2,721,262 - 2,729,365 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	12	2,720,658 - 2,729,394 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	12	2,802,170 - 2,810,395 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	12	3,052,429 - 3,060,890 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	12	3,052,450 - 3,060,598 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	12	2,719,901 - 2,728,119 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	12	2,801,391 - 2,809,605 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	12	2,876,085 - 2,884,317 (-)	NCBI		UU_Cfam_GSD_1.0

Wdr46
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404946	38,373,210 - 38,383,152 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936476	25,577,243 - 25,586,931 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936476	25,577,115 - 25,587,057 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

WDR46
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	7	29,645,130 - 29,653,579 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	7	29,645,128 - 29,653,567 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	7	34,148,893 - 34,157,252 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

WDR46
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	17	38,787,932 - 38,797,940 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	17	38,788,275 - 38,799,858 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666044	33,114,052 - 33,124,178 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Wdr46
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624754	23,532,771 - 23,541,975 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624754	23,532,579 - 23,542,109 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_013516886	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AGCD01034239	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	GBDF01087150	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSCLAT00000011021 ⟹ ENSCLAP00000010887

Type:

CODING

Position:

Chinchilla Assembly	Chr	Position (strand)	Source
ChiLan1.0 Ensembl	NW_004955437	1,840,791 - 1,848,172 (-)	Ensembl

RefSeq Acc Id:

ENSCLAT00000011022 ⟹ ENSCLAP00000010888

Type:

CODING

Position:

Chinchilla Assembly	Chr	Position (strand)	Source
ChiLan1.0 Ensembl	NW_004955437	1,841,007 - 1,848,172 (-)	Ensembl

RefSeq Acc Id:

XM_013516886 ⟹ XP_013372340

Type:

CODING

Position:

Chinchilla Assembly	Chr	Position (strand)	Source
ChiLan1.0	NW_004955437	1,840,875 - 1,848,258 (-)	NCBI

Sequence:

show sequence

AAGCCCAGAGGACTTCCGGAAATTTCCAAGCGGACTGTGCGACAGCTGAGAGTTTTTGCACGTG
GATTGTTGTTCGGGTGGGCGAGATGGAGACGGTTCCTAGGCCGGGCAGGGGTGTCCCGCCCAAG
AAGGACAAACTTCAGGCCAAGCGGAAGAAGCCGCGGCGATACTGGGAGGAAGAGACCGCTCCTG
CCGTTGCCGGGGCCTCTCCAGGCCCGCCTCGCAAGAAGAAGAAGAAGAAGAATCTGGAGGTCCG
CCGCCAAAAGCAGAAGAACTCTCACAACTCCAAGAAGTCTCGGATCTCTAAGAAATCCCAGTTC
AGGAAGAAGTCCCGAGAACAGAAGAAGCCGGGGCCCCAGCGGACCTTGTCTGGGGCCCAAGACC
CATTTCCAGGCCCCGCCCCTGTGCCTCTGGAAGTGGCCCGGAAGTTCCGTCGTATTGACAAATC
CAAGGAGCTACCACATTCTCTGCCCAAAACCCGAAGCAAACTTGAGGTGGCTGAAGCCTTGGAA
GAAGAGATAAGCGTCAAAGCTGCGCGTTCTGAGCTGCTGCTTGCTGAGGAGCCTGGGTTTCTGG
AAGGGGAGGACGGGGAAGACACAGCCAAGATCCGCCAGGCGGACATCGTGGAGGCTGTGGACAT
TGCGAGTGCAGCCAAGCACTTTGACTTGAATCTGCGGCAGTTTGGCCCCTACAGGTTGAACTAC
TCTCGAACTGGGAGACATCTGGCTTTCGGAGGGCGTCGGGGCCATGTGGCTGCCTTCGACTGGG
TGACAAAGAAGCTCATGTGTGAGATCAACGTCATGGAGGCTGTGCGGGACATCCGGTTTCTCCA
CTCGGAGGCACTGCTTGCCGTGGCTCAGAACCGCTGGCTTCACATCTATGACAACCAGGGCATA
GAGCTCCACTGCATCCGCCGCTGTGACCGAGTAACGCGGCTCGAGTTCCTGCCCTTCCACTTCC
TCCTGGCCACAGCTTCAGAGACAGGGTTTCTGACCTACCTGGATGTGTCAGTGGGGAAGATCGT
GGCAGCTCTGAATATTCGGGCTGGACGGCTCAATGTCATGGCTCAGAACCCTTACAACGCTGTC
ATCCACCTTGGACATAGCAATGGTACGGTCTCTTTATGGAGCCCATCTGTGCAGGAGCCACTGG
CAAAGATTCTCTGTCACCGTGGTGGTATTCAGGCTGTGGCAGTGGATTGTACAGGCACGTACAT
GGCCACCTCTGGCCTGGACCACCAACTGAAGGTCTTCGACCTGCGAGGGACATTCCAGCCTCTG
AGCGCTCGGACACTGCCCCAGGGAGCAGGGCACCTGGCCTTTTCCCAGCGGGGCCTGTTGGCTG
CAGGCATGGGTGACGTGGTGAACATATGGGCAGGGCAGGGCAAGGCCAGCCTGCCCTCCCTGGA
GCAGCCCTACCTTACCCACCGGCTGGCCGGCCCTGTGCATGGGCTGCAGTTCTGCCCCTTTGAG
GACGTGCTGGGGGTCGGGCACAGTGGCGGCATCACTAGCATGCTGGTCCCGGGGGCCTCTGAGC
CCAACTTTGATGGCCTGGAGAGCAACCCCTACCGGAGCCGGAAGCAGCGGCAGGAGTGGGAGGT
GAAAGCCCTGCTGGAGAAGGTGCCTGCTGAGCTCATTTGCCTGAACCCCAGGGCCTTGGCAGAG
GTTGACGTAATCTCTTTGGAGCAGCACAAGAAGGAGCGCGTAGAGAGGCTGGGCTACGACCCCG
AGGCCAAGGCGCCCTTCCAGCCAAAGGCAAAGCAGAAAGGCCGCAGCTCCACCGGCAGCCTGGT
GAAGAGGAAGAAGAAGGTCCTGGCGCAGGAGCACAGGGACAAAGTCCGGCAGAGCCTTGAGGAG
CAGCAGAAGCAGAAGCAGAAGCAAAAGGCCAAGCCCACAGGGGCACGGCCGTCTGCCCTGGACA
GATTTGTTCGCTGAGCCAGGCTCCAGGGTGGCCTGGGAACAATGCCCATGCCTCGGGGCACCTG
CAGGGAAATGACTGTGCCCTGGCAGGACAGGACAGCGCCCTTTCCCGAGTGGGGCAGCGGGCTC
TCCGGGTGGGTTGGTATTAAAGAAACGTTTTTGGATACT

hide sequence

Protein Sequences


Protein RefSeqs	XP_013372340	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSCLAP00000010887
	ENSCLAP00000010887.1
	ENSCLAP00000010888.1

RefSeq Acc Id:

XP_013372340 ⟸ XM_013516886

- UniProtKB:

A0A8C2VCX4 (UniProtKB/TrEMBL), A0A8C2V7K7 (UniProtKB/TrEMBL)

- Sequence:

show sequence

METVPRPGRGVPPKKDKLQAKRKKPRRYWEEETAPAVAGASPGPPRKKKKKKNLEVRRQKQKNS
HNSKKSRISKKSQFRKKSREQKKPGPQRTLSGAQDPFPGPAPVPLEVARKFRRIDKSKELPHSL
PKTRSKLEVAEALEEEISVKAARSELLLAEEPGFLEGEDGEDTAKIRQADIVEAVDIASAAKHF
DLNLRQFGPYRLNYSRTGRHLAFGGRRGHVAAFDWVTKKLMCEINVMEAVRDIRFLHSEALLAV
AQNRWLHIYDNQGIELHCIRRCDRVTRLEFLPFHFLLATASETGFLTYLDVSVGKIVAALNIRA
GRLNVMAQNPYNAVIHLGHSNGTVSLWSPSVQEPLAKILCHRGGIQAVAVDCTGTYMATSGLDH
QLKVFDLRGTFQPLSARTLPQGAGHLAFSQRGLLAAGMGDVVNIWAGQGKASLPSLEQPYLTHR
LAGPVHGLQFCPFEDVLGVGHSGGITSMLVPGASEPNFDGLESNPYRSRKQRQEWEVKALLEKV
PAELICLNPRALAEVDVISLEQHKKERVERLGYDPEAKAPFQPKAKQKGRSSTGSLVKRKKKVL
AQEHRDKVRQSLEEQQKQKQKQKAKPTGARPSALDRFVR

hide sequence

RefSeq Acc Id:

ENSCLAP00000010888 ⟸ ENSCLAT00000011022

RefSeq Acc Id:

ENSCLAP00000010887 ⟸ ENSCLAT00000011021

Protein Domains

BING4 C-terminal

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSCLAG00000007512	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSCLAT00000011021	ENTREZGENE
	ENSCLAT00000011021.1	UniProtKB/TrEMBL
	ENSCLAT00000011022.1	UniProtKB/TrEMBL
Gene3D-CATH	2.130.10.10	UniProtKB/TrEMBL
InterPro	BING4_C_dom	UniProtKB/TrEMBL
	WD40/YVTN_repeat-like_dom_sf	UniProtKB/TrEMBL
	WD40_repeat	UniProtKB/TrEMBL
	WD40_repeat_dom_sf	UniProtKB/TrEMBL
	WDR46/Utp7	UniProtKB/TrEMBL
NCBI Gene	Wdr46	ENTREZGENE
PANTHER	PTHR14085	UniProtKB/TrEMBL
	WD REPEAT-CONTAINING PROTEIN 46	UniProtKB/TrEMBL
Pfam	BING4CT	UniProtKB/TrEMBL
	WD40	UniProtKB/TrEMBL
SMART	BING4CT	UniProtKB/TrEMBL
	WD40	UniProtKB/TrEMBL
Superfamily-SCOP	SSF50978	UniProtKB/TrEMBL
UniProt	A0A8C2V7K7	ENTREZGENE, UniProtKB/TrEMBL
	A0A8C2VCX4	ENTREZGENE, UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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