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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2209
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Wdr46
Name: WD repeat domain 46
Acc ID: CHEBI:39867
Term: valproic acid
Definition: A branched-chain saturated fatty acid that comprises of a propyl substituent on a pentanoic acid stem.
Chemical ID: MESH:D014635
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Wdr46affects expressionISOWDR46 (Homo sapiens)6480464CTDValproic Acid affects the expression of WDR46 mRNAPMID:25979313
Wdr46increases expressionISOWDR46 (Homo sapiens)6480464CTDValproic Acid results in increased expression of WDR46 mRNAPMID:23179753
Wdr46increases methylationISOWDR46 (Homo sapiens)6480464CTDValproic Acid results in increased methylation of WDR46 genePMID:29154799
Wdr46multiple interactionsISOWDR46 (Homo sapiens)6480464CTD[Hydralazine co-treated with Valproic Acid] results in increased expression of WDR46 mRNAPMID:17183730
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